Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):364-8. Unique Identifier : AIDSLINE MED/20097664
Demirhan I; Chandra A; Hasselmayer O; Biberfeld P; Chandra P; Department of Molecular Biology, Gustav-Embden Center of; Biological Chemistry, Frankfurt University Medical School,; Germany.
Abstract: Patterns of antibody response to recombinant transactivator protein (HIV-1 tat) in serum samples from HIV-1-negative persons (n = 60), HIV-1-infected asymptomatic persons (n = 20), HIV-1-infected people with Kaposi's sarcoma (n = 25) and of people with Kaposi's sarcoma without HIV-1 infection have been analyzed. None of the healthy people had anti-tat IgG in their serum. All asymptomatic patients with HIV-1 infection were anti-tat IgG-positive. Epitope mapping revealed that these sera have anti-tat IgG to all the functional domains of tat protein. Four of the 25 HIV-1-infected patients with Kaposi's sarcoma were anti-tat IgG-positive; however, epitope analysis revealed that IgG to functional domains of tat protein, in particular to TAR-binding site, were absent. All patients with Kaposi's sarcoma without HIV-1 infection were anti-tat IgG-negative. Presence or absence of anti-tat IgG, and prevalence of different antibody profiles in different groups of patients suggest the pathophysiologic role of tat protein. Thus, a passive immunization with anti-tat IgG could be a useful strategy to influence the pathophysiologic state of the disease.
000430
A0040856
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