Clinico-laboratory characteristics of patients with dermatomyositis accompanied by rapidly progressive interstitial lung disease. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Clinico-laboratory characteristics of patients with dermatomyositis accompanied by rapidly progressive interstitial lung disease.

Clin Rheumatol. 1999;18(6):462-7. Unique Identifier : AIDSLINE MED/20102309
Ito M; Kaise S; Suzuki S; Kazuta Y; Sato Y; Miyata M; Nishimaki T; Nakamura N; Kasukawa R; Department of Internal Medicine II, Fukushima Medical University; School of Medicine, Fukushima City, Japan.

Abstract: The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n = 7) and those with chronic interstitial lung disease (C-ILD, n = 9), and also between deceased (seven RP-ILD and three C-ILD) and living patients (six C-ILD). The extent of muscle weakness of the extremities and frequency of autoantibody positivity were significantly lower in DM patients with RP-ILD than in DM patients with C-ILD. Furthermore, significantly lower serum creatine kinase/lactate dehydrogenase levels (0.26+/-0.27) were found in the 10 patients who died than in the six living patients (1.21+/-1.09). A higher CD4+/CD8+ T-lymphocyte ratio in the peripheral blood (3.51+/-2.65) was detected in the four DM patients with RP-ILD who died than in the six living DM patients with C-ILD (1.22+/-0.49).

Keywords: JOURNAL ARTICLE Adult Antibodies, Antinuclear/BLOOD Bronchoalveolar Lavage Fluid/CYTOLOGY Comparative Study Creatine Kinase/METABOLISM CD4-CD8 Ratio Dermatomyositis/BLOOD/*COMPLICATIONS/MORTALITY/PATHOLOGY Female Human Lactate Dehydrogenase/METABOLISM Lung/PATHOLOGY Lung Diseases, Interstitial/BLOOD/*ETIOLOGY/MORTALITY/PATHOLOGY Male Middle Age Muscle Weakness/PATHOLOGY Muscle, Skeletal/ENZYMOLOGY/PATHOLOGY Radiography, Thoracic T-Lymphocyte Subsets/PATHOLOGY Tomography, X-Ray Computed

KWDjournalarticleadultantibodies,antinuclear/bloodbronchoalveolarlavagefluid/cytologycomparativestudycreatinekinase/metabolismcd4-cd8ratiodermatomyositis/blood/KWDcomplications/mortality/pathologyfemalehumanlactatedehydrogenase/metabolismlung/pathologylungdiseases,interstitial/blood/KWDetiology/mortality/pathologymalemiddleagemuscleweakness/pathologymuscle,skeletal/enzymology/pathologyradiography,thoracict-lymphocytesubsets/pathologytomography,x-raycomputed
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