2000

Falls prevention over 2 years: a randomized controlled trial in women 80 years and older [see comments]: Age Ageing. 1999 Oct;28(6):513-8. Unique Identifier : AIDSLINE MED/20067990; Campbell AJ; Robertson MC; Gardner MM; Norton RN; Buchner DM; Department of Medicine, Dunedin School of Medicine, Otago Medical; School, New Zealand. john.campbell@stonebow.otago.ac.nz; BACKGROUND: after 1 year, a home-based programme of strength and balance retraining exercises was effective in reducing falls and injuries in women aged 80 years and older. The exercise programme had been individually prescribed by a physiotherapist during the first 2 months of a randomized controlled trial. OBJECTIVE
Is pathogenic humoral autoimmunity a Th1 response? Lessons from (for) myasthenia gravis.: Immunol Today. 2000 Jan;21(1):19-23. Unique Identifier : AIDSLINE MED/20107317; Balasa B; Sarvetnick N; Dept of Immunology, The Scripps Research Institute, La Jolla, CA; 92037, USA. bbalasa@scripps.edu
Immunopathology of schistosomiasis: a cautionary tale of mice and men.: Immunol Today. 2000 Jan;21(1):29-35. Unique Identifier : AIDSLINE MED/20107319; Fallon PG; Dept of Pathology, University of Cambridge, Tennis Court Road,; Cambridge, UK CB2 1QP. pgf20@cam.ac.uk
FTC warns against home-use tests for HIV [news]: Oncology (Huntingt). 1999 Dec;13(12):1706. Unique Identifier : AIDSLINE MED/20097277
Increased bleeding associated with protease inhibitor therapy in HIV-positive patients with bleeding disorders.: Br J Haematol. 1999 Dec;107(3):556-9. Unique Identifier : AIDSLINE MED/20050306; Wilde JT; Lee CA; Collins P; Giangrande PL; Winter M; Shiach CR; West Midlands Adult Comprehensive Care Haemophilia Unit, Queen; Elizabeth Hospital, Edgbaston, Birmingham.; april.greenway@university-b.smids.nhs.uk; The use of protease inhibitor (PI) drugs in treatment regimens for HIV-infected patients with hereditary bleeding disorders has been associated with an increased bleeding tendency. To characterize the nature of this bleeding tendency, a retrospective case record analysis was performed on 67 HIV-positive patients with
[Becoming partners: the meaning of caring for patients with HIV and AIDS]: Pflege. 1999 Aug;12(4):230-7. Unique Identifier : AIDSLINE MED/20045872; Spirig R; Fachhochschule Aargau Gesundheit und Soziale Arbeit, Aarau.; The purpose of this study was to understand and describe what constitutes caring as experienced by persons living with HIV and AIDS (PLWAs) along their illness trajectory. Interpretative phenomenology was employed. Six men and one woman living with HIV or AIDS participated in open-ended interviews. Interviews were ana
Role of glycosphingolipids in HIV-1 entry: requirement of globotriosylceramide (Gb3) in CD4/CXCR4-dependent fusion.: Biosci Rep. 1999 Aug;19(4):317-25. Unique Identifier : AIDSLINE MED/20055942; Puri A; Hug P; Jernigan K; Rose P; Blumenthal R; Section of Membrane Structure and Function, LECB, Division of; Basic Sciences, National Cancer Institute, National Institutes of; Health, Frederick, MD 21702-1201, USA. apuri@helix.nih.gov; We have recently shown that addition of human erythrocyte glycosphingolipids (GSL) to non-human CD4+ or GSL-depleted human CD4+ cells rendered those cells susceptible to gp120-gp41-mediated cell fusion (Puri et al., BBRC, 1998). One GSL fraction (Fraction 3) isolated from human erythrocyte GSL mixture exhibited the hi
Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes.: Blood. 2000 Jan 1;95(1):231-40. Unique Identifier : AIDSLINE MED/20076262; Vukmanovic-Stejic M; Vyas B; Gorak-Stolinska P; Noble A; Kemeny DM; Department of Immunology, Guy's, King's, and St. Thomas' School; of Medicine, Rayne Institute, London, United Kingdom.; It has recently become clear that distinct subsets of CD8 T cells, analogous to their CD4 counterparts, exist in rodents and humans. To examine functional differences between human CD8 T-cell subsets, we generated Tc1, Tc2, and Tc0 T-cell clones from the peripheral blood of healthy individuals. The majority of CD8 T-c
Application of the ELISPOT assay to the characterization of CD8(+) responses to Epstein-Barr virus antigens.: Blood. 2000 Jan 1;95(1):241-8. Unique Identifier : AIDSLINE MED/20076263; Yang J; Lemas VM; Flinn IW; Krone C; Ambinder RF; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, MD 21231, USA.; CD8(+) cells have an important role in controlling Epstein-Barr virus (EBV) infection. We adapted the interferon-gamma ELISPOT assay to the quantitative analysis of EBV-specific CD8(+) cells. Using peripheral blood mononuclear cells (PBMCs) from healthy donors, we measured both the aggregate response to the virus, usi
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).: Blood. 2000 Jan 1;95(1):249-55. Unique Identifier : AIDSLINE MED/20076264; Hazenberg MD; Stuart JW; Otto SA; Borleffs JC; Boucher CA; de Boer RJ; Miedema F; Hamann D; Department of Clinical Viro-Immunology, CLB, Academic Medical; Center, University of Amsterdam, Amsterdam, The Netherlands.; In human immunodeficiency virus (HIV)-1 infection, highly increased T-cell turnover was proposed to cause exhaustion of lymphocyte production and consequently development of AIDS. Here, we investigated cell proliferation, as measured by expression of the Ki-67 nuclear antigen, in peripheral blood CD4(+) and CD8(+) lym
Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells.: Blood. 2000 Jan 1;95(1):30-8. Unique Identifier : AIDSLINE MED/20076236; Hasegawa H; Nomura T; Kohno M; Tateishi N; Suzuki Y; Maeda N; Fujisawa R; Yoshie O; Fujita S; First Department of Internal Medicine, Ehime University School of; Medicine, Shigenobu, Ehime 791-0295, Japan.; hitoshih@m.ehime-u.ac.jp; Adult T-cell leukemia (ATL) is characterized by infiltration of various tissues by circulating ATL cells, a finding often associated with a poor prognosis. Leukocyte migration from the circulation into tissues depends on integrin-mediated adhesion to the endothelium, and integrins are tightly regulated by several fact
Changes in human immunodeficiency virus type 1 virus load during mobilization and harvesting of hemopoietic progenitor cells. Adult AIDS Clinical Trials Group 285 Study Team.: Blood. 2000 Jan 1;95(1):48-55. Unique Identifier : AIDSLINE MED/20076238; Campbell TB; Sevin A; Coombs RW; Peterson GC; Rosandich M; Kuritzkes DR; Mladenovic J; Landay A; Wong R; Ambruso D; Miles S; Pomerantz RJ; Schooley RT; University of Colorado Health Sciences Center and Bonfils Blood; Center, Denver, CO 80262, USA. thomas.campbell@uchsc.edu; Genetic modification of hemopoietic progenitor cells ex vivo, followed by the infusion of the genetically modified cells into the human immunodeficiency virus-1 (HIV-1) infected donor, has been proposed as a treatment for HIV-1 infection. The current study was undertaken to evaluate the effect of hemopoietic stem cell
C-C chemokine profile of cord blood mononuclear cells: selective defect in RANTES production.: Blood. 2000 Jan 15;95(2):715-8. Unique Identifier : AIDSLINE MED/20094702; Hariharan D; Ho W; Cutilli J; Campbell DE; Douglas SD; Divisions of Neonatology and Immunologic and Infectious Diseases; and the Clinical Immunology Laboratories, The Children's Hospital; of Philadelphia, University of Pennsylvania School of Medicine,; Philadelphia, PA 19104, USA.; Three C-C chemokines inhibit human immunodeficiency virus (HIV) entry into macrophages: macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and regulated-upon activation, normal T-cell expressed and secreted (RANTES). We studied the ability of placental cord blood mononuclear cells (CBMC) to secrete these
Legal trends in bioethics.: J Clin Ethics. 1999 Summer;10(2):156-65. Unique Identifier : AIDSLINE MED/20099087; Forster HP; Case Western Reserve University School of Medicine, Cleveland,; Ohio, USA.
AZT in Africa [letter]: J Clin Ethics. 1999 Summer;10(2):166-7. Unique Identifier : AIDSLINE MED/20099089; Kottow MH
Comment: significant interactions with new antiretrovirals and psychotropic drugs [letter]: Ann Pharmacother. 1999 Dec;33(12):1372-3. Unique Identifier : AIDSLINE MED/20094539; Penzak SR; Grimsley SR; Jann MW
Comment: risk of drug-disease and disease-drug interactions with anticonvulsants in HIV-positive patients [letter]: Ann Pharmacother. 1999 Dec;33(12):1373-4. Unique Identifier : AIDSLINE MED/20094540; Jennings HR; Romanelli F
Effects of zidovudine (AZT) and dideoxyinosine (ddI) on human trophoblast cells.: Reprod Toxicol. 1999 Nov-Dec;13(6):537-46. Unique Identifier : AIDSLINE MED/20078563; Plessinger MA; Miller RK; University of Rochester School of Medicine and Dentistry,; Department of Obstetrics and Gynecology, New York 14642-8668,; USA. mark_plessinger@urmc.rochester.edu; The anti-HIV agents AZT (zidovudine) and ddl (dideoxyinosine) are being used clinically during pregnancy. The toxicity of these agents to the fetus and placenta remains a concern because few human pregnancy exposure data are available, and pregnant ro
Differential alteration by thalidomide of the glutathione content of rat vs. rabbit conceptuses in vitro.: Reprod Toxicol. 1999 Nov-Dec;13(6):547-54. Unique Identifier : AIDSLINE MED/20078564; Hansen JM; Carney EW; Harris C; University of Michigan, Department of Environmental and; Industrial Health Toxicology Program, Ann Arbor 48109-2029, USA.; Thalidomide has been shown to cause limb reduction defects in rabbits with much greater potency than in rats, possibly due to inherent biochemical differences between the two species. Whole embryo culture was used to make direct comparisons between thalidomide-sensitive New Zealand
Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization.: Cereb Cortex. 1999 Dec;9(8):824-32. Unique Identifier : AIDSLINE MED/20074214; Delalle I; Takahashi T; Nowakowski RS; Tsai LH; Caviness VS Jr; Department of Neurology, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA. idellale@partners.org; We have analyzed the expression patterns of mRNAs of five cell cycle related proteins in the ventricular zone of the neocortical cerebral wall over the course of the neuronogenetic interval in the mouse. One set of mRNAs (cyclin E and p21) are initially expressed at high levels but expression then falls to a low asymp
Gene therapy: lessons learnt from the past decade [interview by Clare Thompson]: BMJ. 1999 Nov 13;319(7220):1310. Unique Identifier : AIDSLINE MED/20025707; Morgan RA; Blaese RM
Supplementation with Lactobacillus reuteri or L. acidophilus reduced intestinal shedding of cryptosporidium parvum oocysts in immunodeficient C57BL/6 mice.: Cell Mol Biol (Noisy-le-grand). 1999 Sep;45(6):855-63. Unique Identifier : AIDSLINE MED/20007494; Alak JI; Wolf BW; Mdurvwa EG; Pimentel-Smith GE; Kolavala S; Abdelrahman H; Suppiramaniam V; Department of Biology, Tuskegee University, Alabama 36088, USA.; Jalak@acd.tusk.edu; The effect of L. acidophilus supplementation to reduce fecal shedding of Cryptosporidium parvum oocysts was compared to L. reuteri using C57BL/6 female mice immunosuppressed by murine leukemia virus (strain LP-BM5) inoculation. After 12 weeks post LP-BM5 inoculation, 15 immunosuppressed mice each were randomly assinge
[Vimentin intermediate filaments are involved in replication of human immunodeficiency virus type I]: Dokl Akad Nauk. 1999 Oct;368(5):706-8. Unique Identifier : AIDSLINE MED/20080094; Khakhulina TV; Vorkunova GK; Manukhina EE; Bukrinskaia AG
Survey of diagnosed HIV infections shows prevalence is rising.: Commun Dis Rep CDR Wkly. 1999 Nov 19;9(47):1. Unique Identifier : AIDSLINE MED/20099826
Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1).: Cell Adhes Commun. 1999;7(3):183-93. Unique Identifier : AIDSLINE MED/20090329; Schenkel AR; Pauza CD; Department of Pathology and Laboratory Medicine and Wisconsin; Regional Primate Research Center, University of; Wisconsin-Madison, 53706, USA.; Pertussis toxin treatment in macaques inhibits lymphocyte extravasation from the blood and leads to transient lymphocytosis and leukocytosis. We examined lymphocyte adhesion molecules known to be involved in the extravasation process to find possible mechanisms for the effects of pertussis toxin treatment. The two sub
Study requirements for investigating HLA-associated progression of HIV disease, and review.: QJM. 1999 Oct;92(10):609-17. Unique Identifier : AIDSLINE MED/20093353; Gore SM; Hutchinson SJ; Brettle RP; MRC Biostatistics Unit, Cambridge, UK.
Long-term outcome of chronic hepatitis C virus infection in primary hypogammaglobulinaemia.: QJM. 1999 Aug;92(8):433-41. Unique Identifier : AIDSLINE MED/20093329; Bjoro K; Skaug K; Haaland T; Froland SS; Department of Medicine, National Hospital, Oslo, Norway.; The clinical course of HCV infection in patients with primary hypogammaglobulinaemia appears to be more severe than in immunocompetent patients. We studied the long-term course of chronic HCV infection in 20 Norwegian hypogammaglobulinaemia patients with a 13-15 year known history of HCV infection. Twelve of 20 patien
Multinucleated giant cell formation by microglia: induction by interleukin (IL)-4 and IL-13.: Brain Res. 1999 Dec 4;849(1-2):239-43. Unique Identifier : AIDSLINE MED/20074719; Suzumura A; Tamaru T; Yoshikawa M; Takayanagi T; Department of Neurology, Nara Medical University, 840 Shijo-cho,; Kashihara, Nara, Japan. asuzumur@naramed-u.ac.jp; To investigate the cellular origin and the mechanisms of multinucleated giant cell (MGC) formation in the CNS, various cytokines were applied to isolated murine microglia. All the single cytokines failed to induce MGC. However, interleukin (IL)-13 and IL-4 induced microglial MGC formation in the presence of colony sti
Stopping anti-CMV therapy may be safe option for some HIV patients [news]: Am J Health Syst Pharm. 2000 Jan 1;57(1):21. Unique Identifier : AIDSLINE MED/20094248
Costs and savings of investigational drug services.: Am J Health Syst Pharm. 2000 Jan 1;57(1):40-3. Unique Identifier : AIDSLINE MED/20094251; McDonagh MS; Miller SA; Naden E; School of Pharmacy, University of Washington, Seattle 98195, USA.; The costs and savings resulting from two pharmacy-based investigational drug services (IDSs) for fiscal year 1996-97 were studied. The costs and savings associated with IDSs at two joint institutions were calculated by adding the cost-avoidance figures (money that would most likely have been spent, but was not because
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells.: Immunity. 1999 Dec;11(6):677-88. Unique Identifier : AIDSLINE MED/20090316; Kurata H; Lee HJ; O'Garra A; Arai N; Department of Immunobiology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, California 94304, USA.; Stat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein that can be activated by 4-hydroxy-tamoxifen, independently of IL-4 and endogenous Stat6. Retrovirus-mediated introduction of Stat6:ER into devel
Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses.: Immunity. 1999 Dec;11(6):733-42. Unique Identifier : AIDSLINE MED/20090321; Selin LK; Lin MY; Kraemer KA; Pardoll DM; Schneck JP; Varga SM; Santolucito PA; Pinto AK; Welsh RM; Department of Pathology, University of Massachusetts Medical; School, Worcester 01655, USA.; Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells s
The role of advanced practice in today's infectious diseases.: Crit Care Nurs Q. 1999 Feb;21(4):22-30. Unique Identifier : AIDSLINE MED/20111907; Davis S; Massachusetts General Hospital, Boston, USA.; The importance of the role of an advanced practice nurse in infectious diseases has been heightened by the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic. The unique abilities that are part of the expanded role enable the advanced practice nurse to utilize tools learned as a nurse
HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system.: Int J Biochem Cell Biol. 1999 Dec;31(12):1443-52. Unique Identifier : AIDSLINE MED/20104764; Idriss H; Kawa S; Damuni Z; Thompson EB; Wilson SH; Sealy Center for Molecular Science, The University of Texas; Medical Branch Galveston, TX 77555-0851, USA. hi@st-and.ac.uk; Phosphorylation modulates the activity of many proteins that interact with nucleic acids including DNA and RNA polymerases. The HIV-1 reverse transcriptase (RT) is essential during the replicative cycle of the HIV-1 virus. HIV-1 RT has several potential sites for phosphorylation that could regulate its activities. In
Treatment of two patients with diffuse cutaneous leishmaniasis caused by Leishmania mexicana modifies the immunohistological profile but not the disease outcome.: Trop Med Int Health. 1999 Dec;4(12):801-11. Unique Identifier : AIDSLINE MED/20098847; Salaiza-Suazo N; Volkow P; Tamayo R; Moll H; Gillitzer R; Perez-Torres A; Perez-Montfort R; Dominguez JD; Velasco-Castrejon O; Crippa M; Becker I; Departamento de Medicina Experimental, Faculdad de Medicina,; UNAM, Mexico.; Two patients with diffuse cutaneous leishmaniasis caused by Leishmania mexicana were treated with two leishmanicidal drugs (pentamidine and allopurinol) combined with recombinant interferon-gamma restoring Th-1 favouring conditions in the patients. Parasites decreased dramatically in the lesions and macrophages dimini
Spontaneous gingival bleeding in an otherwise asymptomatic patient.: Compend Contin Educ Dent. 1999 Oct;20(10):936-40. Unique Identifier : AIDSLINE MED/20116154; Tyler MT; Hutchison JL; Rybka WB; Division of Oral Medicine and Radiology, Faculty of Dentistry,; McGill University, Montreal, Quebec, Canada.; This case is presented to challenge the reader to formulate a differential diagnosis for a patient who visits the dentist with spontaneous, continuous gingival bleeding. When this situation occurs, it is serious and requires immediate attention and a specific treatment plan to arrive at the underlying diagnosis and co
Occupational HIV infections in health care workers.: Compend Contin Educ Dent. 1999 Sep;20(9):882-4, 886. Unique Identifier : AIDSLINE MED/20114217; Molinari JA; Department of Biomedical Sciences, University of Detroit Mercy; School of Dentistry, USA.
Porcine endogenous retroviral mRNAs in pancreas and a panel of tissues from specific pathogen-free pigs.: Diabetes Metab. 1999 Dec;25(6):518-25. Unique Identifier : AIDSLINE MED/20099696; Clemenceau B; Lalain S; Martignat L; Sai P; ENVN, Nantes, France.; Pigs are potential providers of donor tissues for xenotransplantation (e.g. of pancreatic islets) in Type 1 diabetes. In this context, our group has studied the use of islets from specific pathogen-free (SPF) pigs as a means of reducing the risks of conventional zoonosis . Although this approach does not prevent the
Kaposi sarcoma of major salivary gland origin: A clinicopathologic series of six cases.: Cancer. 2000 Jan 1;88(1):15-23. Unique Identifier : AIDSLINE MED/20086736; Castle JT; Thompson LD; Department of Oral and Maxillofacial Pathology, Armed Forces; Institute of Pathology, Washington, DC 20306-6000, USA.; BACKGROUND: Kaposi sarcoma (KS), one of the defining tumors of acquired immune deficiency syndrome (AIDS), is rarely identified in the major salivary glands. To the authors knowledge, no previous published series has evaluated the clinicopathologic aspects of this tumor in major salivary glands. METHODS: Six cases of
HIV infection as a risk factor for shigellosis.: Emerg Infect Dis. 1999 Nov-Dec;5(6):820-3. Unique Identifier : AIDSLINE MED/20070440; Baer JT; Vugia DJ; Reingold AL; Aragon T; Angulo FJ; Bradford WZ; California Emerging Infections Program, San Francisco,; California, USA; We investigated cases of shigellosis in San Francisco and Alameda Counties identified during 1996 by active laboratory surveillance to assess the role of HIV infection as a risk factor for shigellosis. Dramatically elevated rates of shigellosis in HIV-infected persons implicate HIV infection as an important risk facto
The first reported case of Aerococcus bacteremia in a patient with HIV infection [letter]: Emerg Infect Dis. 1999 Nov-Dec;5(6):838-9. Unique Identifier : AIDSLINE MED/20070448; Razeq JH; Thomas GM; Alexander D
CD46 is a cellular receptor for human herpesvirus 6.: Unique Identifier : AIDSLINE MED/20084452; Santoro F; Kennedy PE; Locatelli G; Malnati MS; Berger EA; Lusso P; Unit of Human Virology, DIBIT, San Raffaele Scientific Institute,; Milano, Italy.; Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, causes opportunistic infections in immunocompromised patients, and has been implicated in multiple sclerosis and in the progression of AIDS. Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downreg
Blood mononuclear cells in patients with HTLV-I-associated myelopathy: lymphocytes are highly activated and adhesion to endothelial cells is increased.: Cell Immunol. 1999 Nov 25;198(1):1-10. Unique Identifier : AIDSLINE MED/20080777; Al-Fahim A; Cabre P; Kastrukoff L; Dorovini-Zis K; Oger J; Department of Medicine, University of British Columbia,; Vancouver, British Columbia, V6T 1W5, Canada.; We have investigated lymphocyte subpopulations and blood mononuclear cell (MNC) adhesion to activated endothelial monolayers in patients with human T lymphotropic virus type I (HTLV-I) associated myelopathy (HAM), in HTLV-I asymptomatic carriers (carriers), and in seronegative controls. HAM patients and carriers had h
MHC-restricted protection of cats against FIV infection by adoptive transfer of immune cells from FIV-vaccinated donors.: Cell Immunol. 1999 Nov 25;198(1):30-43. Unique Identifier : AIDSLINE MED/20080780; Pu R; Omori M; Okada S; Rine SL; Lewis BA; Lipton E; Yamamoto JK; Department of Pathobiology, College of Veterinary Medicine,; University of Florida, Gainesville, Florida 32611, USA.; The role of cellular immunity in vaccine protection against FIV infection was evaluated using adoptive cell transfer studies. Specific-pathogen-free cats received two adoptive transfers of washed blood cells from either vaccinated or unvaccinated donors with varying MHC compatibility at 1-week intervals, and a homolog
Microglia exhibit clonal variability in eliciting cytotoxic T lymphocyte responses independent of class I expression.: Cell Immunol. 1999 Nov 25;198(1):44-53. Unique Identifier : AIDSLINE MED/20080781; Bergmann CC; Yao Q; Stohlman SA; Department of Neurology, University of Southern California Keck; School of Medicine, Los Angeles 90033, USA.; Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones
Replication timing of CD4 and CD8 in single-positive peripheral blood lymphocytes.: Cell Immunol. 1999 Nov 25;198(1):61-8. Unique Identifier : AIDSLINE MED/20080783; Hibbard MK; Strehl S; Lalande M; Genetics Division, Children's Hospital and Harvard Medical; School, Boston, Massachusetts 02115, USA.; The regulatory events leading to the mutually exclusive expression of CD4 and CD8 on peripheral lymphocytes are not fully understood. In particular, the association between DNA replication timing and transcriptional activity of these genes has not been previously investigated. Here, the replication kinetics of the CD4
Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity.: Cell Immunol. 1999 Nov 25;198(1):69-75. Unique Identifier : AIDSLINE MED/20080784; Kobayashi H; Horner AA; Takabayashi K; Nguyen MD; Huang E; Cinman N; Raz E; Department of Medicine, University of California at San Diego,; 9500 Gilman Drive, La Jolla, California 92093-0663, USA.; Immunostimulatory DNA sequences (ISS) have been shown to promote CTL and Th1 immune responses to coinjected antigens. This phenomenon can be attributed to the capacity of ISS to induce the secretion of type-1 cytokines and to up regulate costimulatory ligands on antigen-presenting cells. We hypothesized that ISS admin
Conformational studies of irreversible HIV-1 protease inhibitors containing cis-epoxide as an amide isostere.: J Pept Res. 1999 Sep;54(3):242-8. Unique Identifier : AIDSLINE MED/99444750; Ro S; Baek SG; Lee B; Ok JH; Biotech Research Institute, LG Chemical Ltd, Research Park,; Taejon, Korea.; We have carried out NMR and molecular modeling studies of peptidomimetic HIV-1 protease inhibitors , LB71116: Qc-Asn-Phepsi[(1R,2S)-cis-epoxide]Gly-NH-CH(isopropyl)2 where Qc stands for quinaldic acid and LB71148: Qc-(SMe)Pen(O)2-Phepsi[(1R,2S)-cis-epoxide]Gly-NH-CH(
AIDS-related Kaposi's sarcoma: principal pathogenic mechanisms.: J Exp Clin Cancer Res. 1999 Sep;18(3):311-5. Unique Identifier : AIDSLINE MED/20072191; Silvestris N; Divisione di Chirurgia Oncologica, Ospedale Vittorio Emanuele II,; Bisceglie, Italy.; Kaposi s sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppre
Update on study 006--EFV + AZT + 3TC versus the current 'standard of care' IDV + AZT + 3TC.: Int J Clin Pract Suppl. 1999 Jun;103:10-5. Unique Identifier : AIDSLINE MED/20087917; Staszewski S; Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.; Study 006 is a pivotal Phase III, multicentre, randomized, open-label study designed to compare the antiretroviral activity and tolerability of efavirenz (EFV) + zidovudine ( AZT ) + la
Review of NNRTIs: 'today and tomorrow'.: Int J Clin Pract Suppl. 1999 Jun;103:16-20. Unique Identifier : AIDSLINE MED/20087918; Katlama C; Service des Maladies Infectieuses Parasitaires et Tropicales,; Groupe Hospitalier Pitie-Salpetriere, Paris, France.; Since 1996 indinavir in combination with zidovudine + lamivudine has been the standard regimen in the treatment of HIV infection. Although protease inhibitor (PI) containing therapies are very potent, many problems have now been identified that reduce
Efavirenz: resistance and cross-resistance.: Int J Clin Pract Suppl. 1999 Jun;103:21-5. Unique Identifier : AIDSLINE MED/20087919; Clotet B; Hospital Universitari Germans Trias I Pujol, Badalona, Spain.; Resistant strains, the major cause of treatment failure in the management of HIV infection, evolve whenever virus replication is incompletely suppressed by drug therapy. In such cases, genotypic analysis of proviral DNA or phenotypic analysis of viral isolates or recombinant molecular clones can provide useful informa
Paediatric treatment issues.: Int J Clin Pract Suppl. 1999 Jun;103:26-9. Unique Identifier : AIDSLINE MED/20087920; Walters S; St Mary's Hospital Medical School, Imperial College, London, UK.; Compared with the therapeutic options available for the treatment of HIV infection in adults, the therapeutic options available for the treatment of paediatric patients is limited. New anti-HIV agents are needed to broaden the range of effective therapeutic options. However, several factors need to be considered when
Clinical history of efavirenz.: Int J Clin Pract Suppl. 1999 Jun;103:3-7. Unique Identifier : AIDSLINE MED/20087915; Ruiz N; DuPont Pharmaceuticals Company, Wilmington, USA.; Efavirenz (SUSTIVA, DMP 266, EFV) is a novel non-nucleoside reverse transcriptase inhibitor, which shows good inhibitory activity against HIV-1. The pharmacokinetics of efavirenz allow for once daily dosing without regard to meals of normal compositio
Efavirenz: practicalities, considerations and new issues.: Int J Clin Pract Suppl. 1999 Jun;103:30-4. Unique Identifier : AIDSLINE MED/20087921; Moyle G; Chelsea and Westminster Hospital, London, UK.; Concerns about the long-term safety issues with protease inhibitors (PIs) and recent reports of non-PI-containing regimens demonstrating potent and durable suppression of viral replication have brought into question the role of PI therapy. However, a number of issue
Coming therapies: abacavir.: Int J Clin Pract Suppl. 1999 Jun;103:35-8. Unique Identifier : AIDSLINE MED/20087922; Staszewski S; Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.; Abacavir is a nucleoside analogue reverse transcriptase inhibitor (NRTI). It has a good oral availability and penetrates the CNS. The metabolism of abacavir is not dependent on cytochrome P450 thus avoiding significant drug-drug interactions. It has a
Coming therapies: adefovir.: Unique Identifier : AIDSLINE MED/20087923; Angarano G; Adefovir dipivoxil, an acyclic nucleotide phosphonate analogue, demonstrates a potent and sustained antiviral activity. Its long half-life allows once daily administration and due to the observed reduction in L-carnitine plasma levels, supplementation
Coming therapies: amprenavir.: Int J Clin Pract Suppl. 1999 Jun;103:42-4. Unique Identifier : AIDSLINE MED/20087924; Gatell J; Hospital Clinic, Barcelona, Spain.; Amprenavir is a new peptidomimetic inhibitor of the HIV protease enzyme. Amprenavir has a twice daily dosing schedule and can be administered with or without food making it a convenient dosing regimen among the
The picture of future therapy.: Int J Clin Pract Suppl. 1999 Jun;103:45-8. Unique Identifier : AIDSLINE MED/20087925; Gazzard B; Chelsea and Westminster Hospital, London, UK.; Highly active antiretroviral therapy (HAART) consisting of 2 nucleoside reverse transcriptase inhibitors (NRTIs) in combination with a protease inhibitor (PI) or a non nucleoside reverse transcriptase inhibitor (NNRTI) is now regarded as the standard of care in the treatment of HIV infection. However, over the next fe
Interactive debate.: Int J Clin Pract Suppl. 1999 Jun;103:49-52. Unique Identifier : AIDSLINE MED/20087926; Gazzard B; An interactive voting session at the end of the European symposium on evolving therapies provided an opportunity for panel discussion on various therapeutic options based on a series of case studies. The interactive voting and subsequent discussion focused on the preferred options for first-line, second-line and salva
Dose-ranging studies.: Int J Clin Pract Suppl. 1999 Jun;103:8-9. Unique Identifier : AIDSLINE MED/20087916; Manion D; Worldwide Medical Affairs, DuPont Pharmaceuticals Company,; Wilmington, USA.; Several studies have been performed to investigate the appropriate dose of efavirenz (SUSTIVA, DMP 266, EFV) for the treatment of HIV infection. When considering the most appropriate dose, virological, pharmacological, clinical and safety data from these studies were examined.
High-performance liquid chromatographic method for the simultaneous determination of HIV-1 protease inhibitors indinavir, saquinavir and ritonavir in plasma of patients during highly active antiretroviral therapy.: J Chromatogr B Biomed Sci Appl. 1999 Nov 26;735(1):41-50. Unique Identifier : AIDSLINE MED/20094585; Langmann P; Klinker H; Schirmer D; Zilly M; Bienert A; Richter E; Department of Internal Medicine, University of Wurzburg,; Germany.; A new high-performance liquid chromatographic method for the simultaneous determination of indinavir , saquinavir and ritonavir in human plasma is described. Quantitative recovery foll
[Infections of the oral mucosa II. Bacterial, mycotic and viral infections]: Mund Kiefer Gesichtschir. 1999 Nov;3(6):298-308. Unique Identifier : AIDSLINE MED/20107893; Reichart PA; Zentrum fur Zahnmedizin, Universitatsklinikum Charite, Berlin.; petera.reichart@charite.de; Non-specific infections of the oral mucosa are rare; however, they may present during HIV infection in the form of gingivo-periodontal lesions. In some of these Candida albicans may play a role in the pathogenesis. Sexually transmitted bacterial infections such as gonorrhoea and syphilis are frequently associated with
Cure for cancer? AIDS vaccine? Not just yet....: Adv Nurse Pract. 1998 Dec;6(12):29-30, 32, 34. Unique Identifier : AIDSLINE MED/99132772; Leccese C
Candidiasis in children with HIV. A protocol for diagnosis and treatment.: Adv Nurse Pract. 1999 Jul;7(7):61-4. Unique Identifier : AIDSLINE MED/99404989; Schweisguth B; Valley Hospital, Ridgewood, N.J., USA.
Reducing AIDS risk among inner-city women: a review of the Collectivist Empowerment AIDS Prevention (CE-AP) Program.: J Eur Acad Dermatol Venereol. 1999 Nov;13(3):166-74. Unique Identifier : AIDSLINE MED/20105038; MacKenzie JE; Hobfoll SE; Ennis N; Kay J; Jackson A; Lavin J; Department of Psychology, Kent State University, Kent, OH 44242,; USA. jeanmack@aol.com; We discuss the process underlying our HIV-prevention project for young inner-city women. Health interventions are almost uniformly based on individualistic models of health and behavior. In contrast, AIDS and AIDS prevention, by their very social nature, may require more collectivist principles of disease, health, and
EMS provider reluctance to perform mouth-to-mouth resuscitation.: Prehosp Emerg Care. 2000 Jan-Mar;4(1):48-52. Unique Identifier : AIDSLINE MED/20097749; Melanson SW; O'Gara K; Emergency Medicine Residency, St. Luke's Hospital, Bethlehem,; Pennsylvania 18015, USA.; OBJECTIVES: To assess the willingness of EMS providers to perform mouth-to-mouth resuscitation (MMR) both with and without a barrier device (e.g., face shield), while not on duty; and to determine the providers perceived risk from performing MMR and the frequency with which they carry a barrier device. METHODS: A sur
EMTs' knowledge regarding transmission of infectious disease.: Prehosp Emerg Care. 2000 Jan-Mar;4(1):57-61. Unique Identifier : AIDSLINE MED/20097751; Mencl F; Birkle M; Blanda M; Gerson LW; Department of Emergency Medicine, Summa Health, Akron, Ohio; 44304, USA. menclf@summa-health.org; OBJECTIVE: To describe EMTs knowledge of CDC universal precaution guidelines and transmission routes for human immunodeficiency virus (HIV), hepatitis, meningitis, and tuberculosis (TB) and their perceived exposures to and concerns about these diseases. METHODS: A convenience sample of EMTs were surveyed at mandatory
Births and deaths: preliminary data for 1998.: Natl Vital Stat Rep. 1999 Oct 5;47(25):1-45. Unique Identifier : AIDSLINE MED/20106275; Martin JA; Smith BL; Mathews TJ; Ventura SJ; OBJECTIVES: This report presents preliminary data for 1998 on births and deaths in the United States . U.S. data on births are shown by age, race, and Hispanic origin of mother. Natality data on marital status, prenatal care, cesarean delivery, and low birthweight are also presented. Mo
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.: Bioorg Med Chem Lett. 1999 Dec 20;9(24):3411-6. Unique Identifier : AIDSLINE MED/20083372; Uckun FM; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Mao C; Venkatachalam TK; Drug Discovery Program, and Department of Virology, Hughes; Institute, St. Paul, MN 55113, USA.; The thiophene-ethyl thiourea (TET) compound N -[2-(2-thiophene)ethyl]-N -[2-(5-bromopyridyl)]-thiourea (compound HI-443) was five times more potent than trovirdine, 1250 times more potent than nevirapine , 100 times more potent than
Dilated cardiomyopathy associated with simian AIDS in nonhuman primates.: Circulation. 2000 Jan 18;101(2):185-93. Unique Identifier : AIDSLINE MED/20105251; Shannon RP; Simon MA; Mathier MA; Geng YJ; Mankad S; Lackner AA; Department of Medicine, Allegheny General Hospital, Pittsburgh,; PA 15212, USA. rshannon@pgh.auhs.edu; BACKGROUND: Cardiomyopathy is being recognized with increasing frequency in patients with AIDS, yet the relationship between HIV infection and cardiac contractile dysfunction remains obscure. The purpose of the present study was to determine if infection with simian immunodeficiency virus (SIV) in nonhuman primates is
Transbuccal permeation of a nucleoside analog, dideoxycytidine: effects of menthol as a permeation enhancer.: Int J Pharm. 1999 Dec 10;192(2):139-46. Unique Identifier : AIDSLINE MED/20037003; Shojaei AH; Khan M; Lim G; Khosravan R; Department of Pharmaceutical Sciences, School of Pharmacy, Texas; Tech University Health Sciences Center, Amarillo, TX 79106, USA.; The use of a safe and effective permeation enhancer is paramount to the success of a buccal drug delivery system intended for systemic drug absorption. The enhancing effects of menthol (dissolved in an aqueous buffer in the absence of co-enhancers) on buccal permeation of a model hydrophilic nucleoside analog, dideoxy
Management of opportunistic infections in acquired immunodeficiency syndrome. I. Treatment.: Am J Ther. 1998 Jan;5(1):45-9. Unique Identifier : AIDSLINE MED/20091246; Schlager SI; Department of Medicine, Finch University of Health Sciences/The; Chicago Medical School, North Chicago, IL, USA.; A case report of a patient infected with human immunodeficiency virus (HIV) is described. The patient presents with a multitude of medical complaints that are of acute or subacute onset. The medical examination of these complaints is described and includes algorithms for the diagnosis and treatment of the most common
University of Miami Division of Clinical Pharmacology therapeutic rounds: drug-induced hyperkalemia.: Am J Ther. 1998 Mar;5(2):125-32. Unique Identifier : AIDSLINE MED/20091259; Preston RA; Hirsh MJ MD; Oster JR MD; Oster HR MD; Department of Medicine, University of Miami School, 1500 NW 12th; Ave, 15th Floor West, Miami, Florida 33136, USA.; Drug-induced hyperkalemia is an important but often overlooked problem encountered commonly in clinical practice. It may occur in the ambulatory as well as the impatient setting. Every evaluation of a hyperkalemic patient should include a careful review of medications to determine if a drug capable of causing or aggra
Leaving no element of doubt: analysis of proteins using microPIXE.: Structure Fold Des. 1999 Dec 15;7(12):R291-9. Unique Identifier : AIDSLINE MED/20113472; Garman E; Department of Biochemistry, University of Oxford, UK.; elspeth@biop.ox.ac.uk
Anchoring an extended HTLV-1 Rex peptide within an RNA major groove containing junctional base triples.: Structure Fold Des. 1999 Dec 15;7(12):1461-72. Unique Identifier : AIDSLINE PDB/1C4J; Jiang F; Gorin A; Hu W; Majumdar A; Baskerville S; Xu W; Ellington A; Patel DJ; Cellular Biochemistry and Biophysics Program, Memorial; Sloan-Kettering Cancer Center, New York, NY 10021, USA.; BACKGROUND: The Rex protein of the human T cell leukemia virus type 1 (HTLV-1) belongs to a family of proteins that use arginine-rich motifs (ARMs) to recognize their RNA targets. Previously, an in vitro selected RNA aptamer sequence was identified that mediates mRNA transport in vivo when placed in the primary bindin
[A case of anti-GM1 antibody positive HTLV-I associated myelopathy (HAM) with polyneuropathy]: Rinsho Shinkeigaku. 1999 Sep;39(9):971-5. Unique Identifier : AIDSLINE MED/20081232; Yanagihara C; Ihara M; Nishimura Y; Oka N; Department of Neurology, Nishi-Kobe Medical Center, Kobe, Japan.; We report a case of HTLV-I associated myelopathy (HAM) with polyneuropathy. A 59-year old man suffering from progressive paraparesis associated with subclinical polyneuropathy was admitted to our hospital. HTLV-I antibodies in the serum and CSF were positive, and a diagnosis of HAM was made. His laboratory investigati
Antibodies from HIV-positive and AIDS patients bind to an HIV envelope multivalent vaccine.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):317-24. Unique Identifier : AIDSLINE MED/20097658; Carlos MP; Yamamura Y; Diaz-Mitoma F; Torres JV; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis 95616, USA.; A major problem impeding development of an effective HIV vaccine is the rapid antigenic variability that is characteristic of several envelope glycoprotein epitopes. Frequent mutations alter the composition of the most immunogenic regions of the envelope glycoprotein. We have prepared a synthetic immunogen representin
Presence of multiple HIV subtypes and a high frequency of subtype chimeric viruses in heterosexually infected women.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):325-32. Unique Identifier : AIDSLINE GENBANK/AF191348; Iversen AK; Learn GH; Fugger L; Gerstoft J; Mullins JI; Skinhoj P; Department of Infectious Diseases, Rigshospitalet, The National; University Hospital, Copenhagen, Denmark. aifrhm@inet.uni2.dk; The HIV-1 subtype distribution was determined in 41 HIV-positive women (-8% of all HIV-infected women in Denmark ) belonging to different risk groups. HIV p17 gag and env gene subtypes were determined by DNA sequence analysis. Five d
Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) infection in men receiving treatment for HIV-1 infection.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):333-40. Unique Identifier : AIDSLINE MED/20097660; Campbell TB; Fitzpatrick L; MaWhinney S; Zhang X; Schooley RT; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA.; OBJECTIVE: To determine the prevalence of human herpesvirus 8 (HHV-8) infection in men treated for HIV-1 infection in Denver, Colorado. DESIGN: Cross-sectional analysis METHODS: Blood samples were obtained from 216 HIV-1-infected men. Antibody to latency-associated nuclear antigen (LANA) was detected by an immunofluor
Delayed-type hypersensitivity to recombinant HIV envelope glycoprotein (rgp160) after immunization with homologous antigen.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):341-7. Unique Identifier : AIDSLINE MED/20097661; Katzenstein DA; Kundu S; Spritzler J; Smoller BR; Haszlett P; Valentine F; Merigan TC; Stanford University Center for AIDS Research, California 94305,; USA.; Delayed-type hypersensitivity (DTH) responses to intradermal recombinant HIV envelope glycoprotein (rgp160) may assess cell-mediated immune responses to HIV envelope. In three studies, DTH and lymphocyte proliferation responses to rgp160 were obtained in a total of 106 HIV-seropositive subjects with CD4+ counts >400 c
A multicenter, randomized, controlled trial of three preparations of low-dose oral alpha-interferon in HIV-infected patients with CD4+ counts between 50 and 350 cells/mm(3). Division of AIDS Treatment Research Initiative (DATRI) 022 Study Group.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):348-57. Unique Identifier : AIDSLINE MED/20097662; Alston B; Ellenberg JH; Standiford HC; Muth K; Martinez A; Greaves W; Kumi J; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892-7624, USA. BA27E@NIH.GOV; To evaluate the effectiveness of low-dose oral alpha-interferon (alpha-IFN), 247 HIV-infected study subjects received placebo, Alferon LDO, Veldona, or Ferimmune in a randomized, double-blind trial. Subjects had CD4+ counts between 50 and 350 cells/mm3 and HIV-related symptoms at entry. Study subjects rated the severi
Disease progression, adherence, and response to protease inhibitor therapy for HIV infection in an Urban Veterans Affairs Medical Center.: Unique Identifier : AIDSLINE MED/20097663; Maher K; Klimas N; Fletcher MA; Cohen V; Maggio CM; Triplett J; Valenzuela R; Dickinson G; Pathology Service, Department of Veterans Affairs Medical Center,; Miami, Florida, USA.; Indinavir therapy has demonstrated promise in the treatment of HIV-1 infection in clinical trials; however, its efficacy in a U.S. Veterans Affairs Medical Center, where access to therapy is generally unimpeded, is unknown. A review of the Miami cohor
Detection of distinct patterns of anti-tat antibodies in HIV-infected individuals with or without Kaposi's sarcoma.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):364-8. Unique Identifier : AIDSLINE MED/20097664; Demirhan I; Chandra A; Hasselmayer O; Biberfeld P; Chandra P; Department of Molecular Biology, Gustav-Embden Center of; Biological Chemistry, Frankfurt University Medical School,; Germany.; Patterns of antibody response to recombinant transactivator protein (HIV-1 tat) in serum samples from HIV-1-negative persons (n = 60), HIV-1-infected asymptomatic persons (n = 20), HIV-1-infected people with Kaposi s sarcoma (n = 25) and of people with Kaposi s sarcoma without HIV-1 infection have been analyzed. None
A comparison of exposure groups in the EuroSIDA study: starting highly active antiretroviral therapy (HAART), response to HAART, and survival.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):369-78. Unique Identifier : AIDSLINE MED/20097665; Mocroft A; Madge S; Johnson AM; Lazzarin A; Clumeck N; Goebel FD; Viard JP; Gatell J; Blaxhult A; Lundgren JD; Royal Free Centre for HIV Medicine, Royal Free and University; College Medical School, London, England. amanda@rfhsm.ac.uk; BACKGROUND: Concerns have been raised that intravenous drug users may be less likely to start highly active antiretroviral therapy (HAART) and that adherence to therapy may be poor among this group of patients. Given the decreased mortality and incidence of AIDS-defining illnesses among patients with HIV who start HAA
Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):379-85. Unique Identifier : AIDSLINE MED/20097666; Wabwire-Mangen F; Gray RH; Mmiro FA; Ndugwa C; Abramowsky C; Wabinga H; Whalen C; Li C; Saah AJ; Institute of Public Health, Makerere University, Kampala, Uganda.; Prospective follow-up of 172 HIV-infected pregnant women and their infants was conducted at Mulago Hospital, Kampala, Uganda during 1990 to 1992. Information was collected on maternal immune status (CD4 counts or clinical AIDS), and concurrent infections with sexually transmitted d
Virologic, immunologic, and immune activation markers as predictors of HIV-associated weight loss prior to AIDS. Multicenter AIDS Cohort Study.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):386-94. Unique Identifier : AIDSLINE MED/20097667; Lyles RH; Tang AM; Smit E; Mellors JW; Margolick JB; Visscher BR; Phair JP; Graham NM; Emory University, Atlanta, Georgia, USA.; OBJECTIVES: To study weight patterns among HIV-positive men and associations of baseline HIV RNA, CD4+ lymphocyte count, and serum levels of neopterin and beta2-microglobulin with subsequent weight loss prior to AIDS. METHODS: A cohort of 1558 homosexual men from the Multicenter AIDS Cohort Study comprised the main st
Rates of receiving HIV test results: data from the U.S. National Health Interview Survey for 1994 and 1995.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):395-400. Unique Identifier : AIDSLINE MED/20097668; Tao G; Branson BM; Kassler WJ; Cohen RA; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention (CDC), Atlanta, Georgia 30333,; USA.; OBJECTIVE: To determine the frequency and predictors of receipt of HIV test results. METHODS: Analysis of responses from 19,127 adults in 1994 and 16,848 in 1995 surveyed for the U.S. National Health Interview Survey, using logit models to determine factors independently associated with decreased likelihood of receivi
Drug resistance mutations among HIV-1 strains from antiretroviral-naive patients in Martinique, French West Indies.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):401-5. Unique Identifier : AIDSLINE MED/20097669; Cesaire R; Dos Santos G; Abel S; Bera O; Sobesky G; Cabie A; L'Etablissement de Transfusion Sanguine, Centre Hospitalier et; Universitaire de Fort-de-France, Martinique.; We report on the frequency of genetic mutations associated with drug resistance in antiretroviral treatment-naive patients from Martinique (French West Indies), where zidovudine (ZDV) has been available since 1987 and where
Abacavir in combination with the inosine monophosphate dehydrogenase (IMPDH)-inhibitor mycophenolic acid is active against multidrug-resistant HIV-1 [letter]: Unique Identifier : AIDSLINE MED/20097670; Heredia A; Margolis D; Oldach D; Hazen R; Le N; Redfield R
HAART is effective as anti-Kaposi's sarcoma therapy only after remission has been induced by chemotherapy [letter]: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):407-8. Unique Identifier : AIDSLINE MED/20097671; Vaccher E; di Gennaro G; Nasti G; Juzbasic S; Tirelli U
Influence of seasonal variation with enteric microsporidiosis among HIV-infected individuals [letter]: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):408-9. Unique Identifier : AIDSLINE MED/20097672; Kopicko JJ; Frazer T; Dascomb K; Clark R; Didier ES; Kissinger P
Seroprevalence of HTLV-I in Cheju Island, a Korean island adjacent to the endemic area of Japan [letter]: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):409-12. Unique Identifier : AIDSLINE MED/20097673; Kim JM; Chang KH; Choi YH; Song YG; Kang SM; Yoon TY; Choi JM; Park SY; Lew DJ
Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.: Clin Sci (Colch). 1999 Dec;97(6):707-18. Unique Identifier : AIDSLINE MED/20054202; Price DA; O'callaghan CA; Whelan JA; Easterbrook PJ; Phillips RE; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, Oxford OX3 9DU, U.K. dprice@worf.molbiol.ox.ac.uk; Efforts to develop immune-based therapies for HIV infection have been impeded by incomplete definition of the immunological correlates of protection. Despite many precedents demonstrating that CD8(+) cytotoxic T lymphocytes are key mediators of protective anti-viral immunity in non-human animal models, direct evidence
Clinico-laboratory characteristics of patients with dermatomyositis accompanied by rapidly progressive interstitial lung disease.: Clin Rheumatol. 1999;18(6):462-7. Unique Identifier : AIDSLINE MED/20102309; Ito M; Kaise S; Suzuki S; Kazuta Y; Sato Y; Miyata M; Nishimaki T; Nakamura N; Kasukawa R; Department of Internal Medicine II, Fukushima Medical University; School of Medicine, Fukushima City, Japan.; The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n = 7) and those with chronic interstitial lung disease (C-ILD, n = 9), and also between deceased (seven RP-ILD and three C-ILD) and living pa
Population structure of pathogens: the role of immune selection.: Parasitol Today. 1999 Dec;15(12):497-501. Unique Identifier : AIDSLINE MED/20038273; Gupta S; Anderson RM; Wellcome Trust Centre for the Epidemiology of Infectious Disease; in the Department of Zoology, University of Oxford, South Parks; Road, Oxford, UK OX1 3PS. sunetra.gupta@zoology.ox.ac.uk; Sunetra Gupta and Roy Anderson discuss how the balance between host immune responses against conserved and variable antigens shapes the population structure of pathogens. At one extreme, immune selection against polymorphic determinants can cause pathogen populations to self-organize spontaneously into discrete antige
Immunolocalization of IL-1beta and IL-6 in optic nerves of patients with AIDS.: Curr Eye Res. 1999 Sep;19(3):264-8. Unique Identifier : AIDSLINE MED/99418970; Saadati HG; Khan IA; Lin XH; Kadakia AB; Heller KB; Sadun AA; University of Southern California School of Medicine Doheny Eye; Institute Department of Ophthalmology, Los Angeles 90033, USA.; PURPOSE. Immunohistochemical procedures were employed to test the hypothesis that cytokines such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are involved in AIDS-related optic neuropathy and to determine the primary cell types involved. METHODS. Fixed sections of six human HIV-1 infected optic nerves were
Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis.: Dig Dis Sci. 1999 Dec;44(12):2530-7. Unique Identifier : AIDSLINE MED/20094204; Perez-Machado MA; Espinosa LM; de la Madrigal EJ; Abreu L; Lorente GM; Alvarez-Mon M; University Department of Paediatric Gastroenterology, Royal Free; Hospital, London, UK.; An abnormal immune response may play a pathogenic role in ulcerative colitis (UC). Animal models suggest that T-cell regulation may be of central importance in the inflammatory process. Our aims were the characterization of the phenotype and functional status of circulating T-cells in ulcerative colitis patients and t
Host cyclophilin A mediates HIV-1 attachment to target cells via heparans.: EMBO J. 1999 Dec 1;18(23):6771-85. Unique Identifier : AIDSLINE MED/20050571; Saphire AC; Bobardt MD; Gallay PA; Department of Immunology IMM-9, The Scripps Research Institute,; 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; The present study proposes a novel mode of action for cyclophilin A (CypA) in the HIV-1 life cycle. We demonstrate that CypA-deficient viruses do not replicate because they fail to attach to target cells. We show that CypA is exposed at the viral membrane and mediates HIV-1 attachment. We identify heparan as the exclu
Circular dichroism and fluorescence spectroscopic properties of the major core protein of feline immunodeficiency virus and its tryptophan mutants. Assignment of the individual contribution of the aromatic sidechains.: Eur J Biochem. 1999 Dec;266(3):1081-9. Unique Identifier : AIDSLINE MED/20050623; Yelamos B; Nunez E; Gomez-Gutierrez J; Datta M; Pacheco B; Peterson DL; Gavilanes F; Departamento de Bioquimica y Biologia Molecular I, Facultad de; Ciencias Quimicas, Universidad Complutense de Madrid, Spain.; The gene coding for the major capsid protein of feline immunodeficiency virus (FIV) has been cloned into the expression vector pQE60, which allows protein purification by affinity chromatography on a nitrilotriacetic acid/Ni/agarose column. The gene was expressed in Escherichia coli and the resultant soluble protein (
[Socioeconomic inequalities in health care efficacy. Three examples in Lazio region]: Epidemiol Prev. 1999 Jul-Sep;23(3):153-60. Unique Identifier : AIDSLINE MED/20073174; Rapiti E; Perucci CA; Agabiti N; Ancona C; Arca M; Di Lallo D; Forastiere F; Miceli M; Porta D; There has been a limited number of studies in Italy investigating the relationship between socioeconomic inequalities and efficacy of treatments. This paper reviews three case studies on the association between socioeconomic status and disease outcome in the Lazio Region, Italy. The
[Socioeconomic inequalities in health in the Tuscany Longitudinal Study (SLTO): persistence and changes over time in overall mortality and selected causes (lung cancer, liver cirrhosis, AIDS and overdose)]: Epidemiol Prev. 1999 Jul-Sep;23(3):207-14. Unique Identifier : AIDSLINE MED/20073179; Merler E; Benvenuti A; Baldi P; Nardulli MC; Olmastroni L; Biggeri A; Marchi M; Dreassi E; Unita Operativa di Epidemiologia, Azienda Ospedaliera Careggi,; Firenze.; We evaluate the persistence of social inequalities in overall mortality or mortality by causes (lung cancer, liver cirrhosis; AIDS and overdose) in the Tuscany Longitudinal Study (SLTo), a record linkage-study on the census population identified at the 1981 and 1991 censuses in Leghorn (1981: 175,741 subjects; 1991: 1
The effectiveness of condoms in reducing heterosexual transmission of HIV.: Fam Plann Perspect. 1999 Nov-Dec;31(6):272-9. Unique Identifier : AIDSLINE MED/20080154; Davis KR; Weller SC; Department of Preventive Medicine and Community Health, the; University of Texas Medical Branch, Galveston, USA.; CONTEXT: It is not established whether the condom is as effective at preventing heterosexual transmission of HIV as it is for preventing conception. An overall estimate of condom effectiveness for HIV prevention is needed. METHODS: Information on condom usage and HIV serology was obtained from 25 published studies of
Reproductive health and intimate partner violence.: Fam Plann Perspect. 1999 Nov-Dec;31(6):302-6. Unique Identifier : AIDSLINE MED/20080158; Moore M
Targeting of HIV gp120 by oligonucleotide-photosensitizer conjugates. Light-induced damages.: FEBS Lett. 1999 Dec 3;462(3):467-71. Unique Identifier : AIDSLINE MED/20086459; Vever-Bizet C; Boutorine AS; Delgado O; Brault D; Helene C; Laboratoire de Photobiologie, Museum National d'Histoire; Naturelle, INSERM U 201, CNRS UMR 8646, Paris, France.; Some guanine-rich oligonucleotides inhibit HIV infectivity through interaction with the gp120 glycoprotein. Besides, photoinactivation of viruses attracts attention for blood decontamination. The feasibility of targeting a red light-absorbing chlorin-type photosensitizer to gp120 through covalent coupling with 8-mer p
Primary response of naive CD4(+) T cells to amino acid-substituted analogs of an antigenic peptide can show distinct activation patterns: Th1- and Th2-type cytokine secretion, and helper activity for antibody production without apparent cytokine secretion.: FEBS Lett. 2000 Jan 7;465(1):28-33. Unique Identifier : AIDSLINE MED/20088793; Ise W; Totsuka M; Takato R; Hachimura S; Sato T; Ametani A; Kumagai Y; Habu S; Kaminogawa S; Department of Applied Biological Chemistry, The University of; Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.; Naive CD4(+) T cells differentiate into two types of helper T cells showing an interferon-gamma-predominant (Th1) or an interleukin-4-predominant (Th2) cytokine secretion profile after repeated antigenic stimulation. Their differentiation can be influenced by slight differences in the interaction between the T cell re
Management of ocular manifestations in patients with acquired immunodeficiency syndrome.: Dev Ophthalmol. 1999;31:192-209. Unique Identifier : AIDSLINE MED/20105963; Pivetti-Pezzi P; Accorinti M; Servizio Speciale di Immunovirologia Oculare, Universita di Roma; La Sapienza, Roma, Italia. uveiti.piv.@iol.it
Risk factors for cervical squamous intraepithelial lesions among HIV-1 seropositive women in Dar es Salaam, Tanzania.: Int J Gynaecol Obstet. 1999 Nov;67(2):87-94. Unique Identifier : AIDSLINE MED/20100007; Kapiga SH; Msamanga GI; Spiegelman D; Mwakyoma H; Fawzi WW; Hunter DJ; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; OBJECTIVES: To determine the prevalence and risk factors for cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Dar es Salaam, Tanzania . METHODS: Between July 1996 and December 1997 we interviewed 691 HIV-infected women to obtain information about risk fa
The use of paclitaxel and cisplatin in a patient with epithelial ovarian cancer and human immunodeficiency virus.: Gynecol Oncol. 2000 Jan;76(1):118-22. Unique Identifier : AIDSLINE MED/20088869; Knox SN; Robinson JB; Im DD; Logan L; Rosenshein NB; Department of Obstetrics, Gynecology, and the Reproductive; Sciences, University of Maryland Medical Systems, Baltimore,; Maryland, 21201, USA.; OBJECTIVE: Several spots exist of human immunodeficiency virus (HIV)-positive patients developing epithelial ovarian cancer. The optimal chemotherapeutic regimen has been unclear due to potential immunotoxicity from chemotherapy in these already immunocompromised patients. This is the first report of paclitaxel-based
E-Cadherin and CD44 expression in cervical intraepithelial neoplasia: comparison between HIV-positive and HIV-negative women and correlation with HPV status.: Gynecol Oncol. 2000 Jan;76(1):56-62. Unique Identifier : AIDSLINE MED/20088858; Darai E; Walker-Combrouze F; Benifla JL; Henin D; Feldmann G; Madelenat P; Scoazec JY; Service de Gynecologie, Hopital Bichat-Claude Bernard, Paris.; AIMS: We aimed to compare the expression patterns of E-cadherin and CD44 isoforms in cervical intraepithelial neoplasia (CIN) between patients with or without infection by the human immunodeficiency virus (HIV). METHODS: An immunohistochemical analysis using the monoclonal antibody HECD-1 against E-cadherin and the mo
The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice.: Immunology. 1999 Dec;98(4):510-9. Unique Identifier : AIDSLINE MED/20062755; Igietseme JU; Ananaba GA; Bolier J; Bowers S; Moore T; Belay T; Lyn D; Black CM; Department of Microbiology, Morehouse School of Medicine, Spelman; College, Atlanta, GA, USA.; Recent studies in animal models of genital chlamydial disease revealed that early recruitment of dendritic cells and specific T helper type-1 (Th1) cells into the genital mucosae is crucial for reducing the severity of the acute phase of a cervico-vaginal infection and arresting ascending disease. These immune effecto
Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization.: Immunology. 1999 Dec;98(4):519-24. Unique Identifier : AIDSLINE MED/20062756; Aoki I; Itoh S; Yokota S; Tanaka S; Ishii N; Okuda K; Minami M; Klinman DM; Department of Pathology, Yokohama City University School of; Medicine, Yokohama, Japan.; This work examines the contribution of mast cells to the synergistic enhancement of the T helper 2 (Th2) immune response elicited following simultaneous oral and subcutaneous (s.c.) immunization. The s.c. route induced a Th1-biased immune response, characterized by increased interferon-gamma (IFN-gamma) and immunoglob
Schistosomal egg antigen-responsive CD8 T-cell population in Schistosoma mansoni-infected BALB/c mice.: Immunology. 1999 Dec;98(4):525-34. Unique Identifier : AIDSLINE MED/20062757; Pancre V; Delacre M; Herno J; Auriault C; Laboratoire dImmunopathologie cellulaire des maladies; infectieuses, Lille, France,; We demonstrated here that schistosomal egg antigen (SEA) is able to stimulate an antigen-specific, cytotoxic CD8+ T-cell response in mice. Indeed, a single i.p. immunization with SEA resulted in the in vivo induction of significant cytotoxic T lymphocyte (CTL) activity in the spleen within 20 days. Effector cells were
Effects of alpha-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Valpha24+ Vbeta11+ T cells.: Immunology. 1999 Dec;98(4):557-63. Unique Identifier : AIDSLINE MED/20062761; Van Der Vliet HJ; Nishi N; Koezuka Y; Peyrat MA; Von Blomberg BM; Van Den Eertwegh AJ; Pinedo HM; Giaccone G; Scheper RJ; Department of Medical Oncology, University Hospital Vrije; Universiteit, Amsterdam, The Netherlands.; The alpha-galactosylceramide KRN7000 was reported to be presented by CD1d to natural killer (NK) T cells, cells that are thought to play an important role in the rejection of malignant tumours and in the regulation of several autoimmune diseases. Here we analysed human peripheral blood (PB) NK T cells (Valpha24+ Vbeta
Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats.: Immunology. 1999 Dec;98(4):590-4. Unique Identifier : AIDSLINE MED/20062766; Jung CG; Kamiyama T; Agui T; Center for Experimental Animal Science, Nagoya City University; Medical School, Nagoya, Japan.; Thymocytes and peripheral lymphocytes of BioBreeding (BB) diabetes-prone (BBDP) and diabetes-resistant (BBDR) rat were analysed by fluorescence-activated cell sorter (FACS). The number of CD4- CD8-, CD4+ CD8-, CD4- CD8+ and CD4+ CD8+ subsets was not different between BBDP and BBDR rat thymocytes, whereas spleen and ly
Mice transgenic for a soluble form of murine cytotoxic T lymphocyte antigen 4 are refractory to murine acquired immune deficiency sydrome development.: Unique Identifier : AIDSLINE MED/20062771; De Leval L; Debrus S; Lane P; Boniver J; Moutschen M; Laboratory of Pathology, University of Liege, Liege, Belgium.; Interactions between B and CD4+ T cells are central to the pathogenesis of retrovirus-induced murine acquired immune deficiency virus (MAIDS). Prompted by previous work showing that treatment with cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) partly inhibited the disease, we studied the course of infection
Tuberculosis in Europe at the end of the second millennium [editorial; comment]: Infection. 1999 Nov-Dec;27(6):311-2. Unique Identifier : AIDSLINE MED/20089714; Ruef C
Infection of the central nervous system by Mycobacterium tuberculosis in patients infected with human immunodeficiency virus (the new neurotuberculosis).: Infection. 1999 Nov-Dec;27(6):313-7. Unique Identifier : AIDSLINE MED/20089715; Sanchez-Portocarrero J; Perez-Cecilia E; Romero-Vivas J; Department of Medicine, Faculty of Health Sciences, European; University of Madrid, Spain. jorge.sanchez@ema.cisa.uem.es; Neurologic complications of HIV infection are numerous. This review focuses on the clinical presentation, diagnostic particularities and therapeutic issues of neurotuberculosis. The pertinent literature describing this important infection is succinctly summarized with a particular emphasis on the discussion of differe
Epidemiological study of tuberculosis in Palermo, Italy: IS6110 fingerprinting of Mycobacterium tuberculosis strains isolated in the years 1994-1998 [see comments]: Infection. 1999 Nov-Dec;27(6):318-22. Unique Identifier : AIDSLINE MED/20089716; Nastasi A; Mammina C; Medical School, Department of Hygiene and Microbiology G.; D'Alessandro, Palermo, Italy. diptigmi@mbox.unipa.it; In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of
Molecular epidemiology of tuberculosis among HIV-infected persons in Switzerland: a countrywide 9-year cohort study. Swiss HIV Cohort Study [see comments]: Infection. 1999 Nov-Dec;27(6):323-30. Unique Identifier : AIDSLINE MED/20089717; Sudre P; Pfyffer GE; Bodmer T; Prod'hom G; Furrer H; Bassetti S; Bernasconi E; Matter L; Telenti A; Strassle A; Jacques JP; Weber R; University Hospital, Geneva. PHILIPPE.SUDRE@HOSPVD.CH; We investigated tuberculosis transmission during a nine-year period (1988-1996) in a countrywide community-based cohort of HIV-infected persons in Switzerland (the Swiss HIV Cohort Study [SHCS]). We estimated the proportion of tuberculosis cases due to reinfection and relapse,
Negative predictors of survival in HIV-infected patients with culture-confirmed pulmonary tuberculosis.: Infection. 1999 Nov-Dec;27(6):331-4. Unique Identifier : AIDSLINE MED/20089718; Palmieri F; Pellicelli AM; Girardi E; De Felici AP; De Mori P; Petrosillo N; Ippolito G; II Divisione IRCCS L. Spallanzani, Rome, Italy.; f.palmieri@flashnet.it; We performed a retrospective study based on chart review of 118 HIV-infected patients with culture-confirmed pulmonary TB, in which M. tuberculosis isolates were tested for drug susceptibility. Patients were enrolled in the period January 1987 to December 1996 and followed until September 1997. The median survival for
Detection and genetic polymorphism of human herpes virus type 8 in endemic or epidemic Kaposi's sarcoma from West and Central Africa, and South America.: Int J Cancer. 2000 Jan 15;85(2):166-70. Unique Identifier : AIDSLINE MED/20094791; Fouchard N; Lacoste V; Couppie P; Develoux M; Mauclere P; Michel P; Herve V; Pradinaud R; Bestetti G; Huerre M; Tekaia F; de The G; Gessain A; Unite d'Epidemiologie des Virus Oncogenes, Departement SIDA; et Retrovirus, Institut Pasteur, Paris, France.; Kaposi s-sarcoma-associated herpesvirus(KSHV)/human-herpes-virus-8(HHV-8) sequences originally detected in AIDS-associated Kaposi s sarcoma have been found in almost every KS tested, whether endemic, classic, iatrogenic or epidemic. Most of the studies on African KS involved East African patients. We report herewith t
HPV-based cervical cancer screening in a population at high risk for HIV infection.: Int J Cancer. 2000 Jan 15;85(2):206-10. Unique Identifier : AIDSLINE MED/20094798; Womack SD; Chirenje ZM; Gaffikin L; Blumenthal PD; McGrath JA; Chipato T; Ngwalle S; Munjoma M; Shah KV; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, MD 21205-2179, USA. smizell@jhsph.edu; We determined the utility of an assay for 13 cancer-associated HPV types in primary cervical cancer screening of Zimbabwe women at high risk of HIV infection. HIV antibody status was determined by ELISA of oral mucosal specimens, and HPV DNA in the genital tract was identified by
A search for human herpesvirus 8 (HHV-8) in HIV-1 infected mothers and their infants does not suggest vertical transmission of HHV-8 [letter]: Int J Cancer. 2000 Jan 15;85(2):296-7. Unique Identifier : AIDSLINE MED/20094811; Calabro ML; Gasperini P; Barbierato M; Ometto L; Zanchetta M; De Rossi A; Chieco-Bianchi L
A study of HTLV-I infection and breast cancers in Trinidad and Tobago [letter]: Int J Cancer. 2000 Jan 15;85(2):298-9. Unique Identifier : AIDSLINE MED/20094812; Jack N; Edwards J; Dhanessar W; Benjamin H; Bartholomew C
[Immunosuppression caused by head and neck surgery]: HNO. 1999 Oct;47(10):885-92. Unique Identifier : AIDSLINE MED/20020106; Heimlich F; Dietz A; Daniel V; Maier H; Universitats-HNO-Klinik Heidelberg.; The immunomodulating effect of primary surgical intervention was investigated in 33 patients with squamous cell carcinomas of the oral cavity, pharynx and larynx. An operation time longer than 7 h was significantly associated with a decrease in lymphocytes, CD4(+) T-lymphocytes and CD8(+) T-lymphocytes. The CD4/CD8-ra
The role of human herpesvirus-8 in the pathogenesis of multiple myeloma.: Hematol Oncol Clin North Am. 1999 Dec;13(6):1159-67. Unique Identifier : AIDSLINE MED/20091587; Sjak-Shie NN; Vescio RA; Berenson JR; Division of Hematology and Oncology, University of California; School of Medicine, Los Angeles, USA.; Human herpesvirus-8 has been strongly implicated in the pathogenesis of KS, BCBL, and multicentric Castleman s disease. Evidence for its role in the pathogenesis of multiple myeloma is accumulating. Human herpesvirus-8 is detectable in the nonmalignant bone marrow dendritic cells from most myeloma patients. In additio
Letter urges access to sterile syringes [news]: J Ark Med Soc. 1999 Dec;96(7):243. Unique Identifier : AIDSLINE MED/20093604
Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.: J Biol Chem. 1999 Dec 3;274(49):34515-8. Unique Identifier : AIDSLINE MED/20044692; Matsuda S; Suzuki-Fujimoto T; Minowa A; Ueno H; Katamura K; Koyasu S; Department of Immunology, Keio University School of Medicine, 35; Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; CD8 deficiency is an autosomal recessive form of severe combined immunodeficiency diseases characterized by the absence of CD8(+) T lymphocytes and impaired T cell functions. We identified two novel mis-sense mutations in the zap70 genes of a CD8-deficiency patient. One mutation (P80Q) affects a residue in an SH2 doma
Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.: J Biol Chem. 1999 Dec 3;274(49):34719-27. Unique Identifier : AIDSLINE MED/20044722; Blanpain C; Doranz BJ; Vakili J; Rucker J; Govaerts C; Baik SS; Lorthioir O; Migeotte I; Libert F; Baleux F; Vassart G; Doms RW; Parmentier M; IRIBHN, Universite Libre de Bruxelles, Campus Erasme, 808 Route; de Lennik, B-1070 Bruxelles, Belgium.; CCR5 is a functional receptor for MIP-1alpha, MIP-1beta, RANTES (regulated on activation normal T cell expressed), MCP-2, and MCP-4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses. By using CCR5-CCR2b chimeras, we have shown previously that the second extracellular l
The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions.: J Biol Chem. 1999 Dec 3;274(49):34765-72. Unique Identifier : AIDSLINE MED/20044729; Foti M; Cartier L; Piguet V; Lew DP; Carpentier JL; Trono D; Krause KH; Department of Morphology, Geneva Medical School, University of; Geneva, CH-1225 Geneva, Switzerland.; Human immunodeficiency virus Nef plays an important role in AIDS pathogenesis. In addition to the well known down-regulation of cell surface receptors (CD4, MHCI), Nef is able to alter cellular signaling. Of particular interest for this study is the ability of Nef to bind with a very high affinity to SH3 domains of my
Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions.: J Biol Chem. 1999 Dec 3;274(49):34911-5. Unique Identifier : AIDSLINE MED/20044748; Tarasova NI; Rice WG; Michejda CJ; Molecular Aspects of Drug Design Section, ABL-Basic Research; Program, NCI-Frederick Cancer Research and Development Center,; Frederick, Maryland 21702, USA. Tarasova@ncifcrf.gov; G-protein-coupled receptors (GPCR) represent a superfamily of proteins that mediate the function of neurotransmitters and peptide hormones and are involved in viral entry and perception of light, smell, and taste. GPCRs are characterized by the presence of seven transmembrane domains (TMs). We demonstrate here that st
p56(lck), ZAP-70, SLP-76, and calcium-regulated effectors are involved in NF-kappaB activation by bisperoxovanadium phosphotyrosyl phosphatase inhibitors in human T cells.: J Biol Chem. 1999 Dec 3;274(49):35029-36. Unique Identifier : AIDSLINE MED/20044764; Ouellet M; Barbeau B; Tremblay MJ; Centre de Recherche en Infectiologie, Centre Hospitalier; Universitaire du Quebec, Pavillon CHUL and Departement de; Biologie Medicale, Faculte de Medecine, Universite Laval,; Sainte-Foy Quebec G1V 4G2, Canada.; This study investigates the second messengers involved in NF-kappaB activation by the bisperoxovanadium (bpV) phosphotyrosyl phosphatase inhibitors. We first initiated a time course analysis of bpV-mediated activation of the human immunodeficiency virus type-1 long terminal repeat- and NF-kappaB-driven reporter gene.
Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.: J Biol Chem. 1999 Dec 3;274(49):35119-28. Unique Identifier : AIDSLINE MED/20044777; Zapata DA; Pacheco-Castro A; Torres PS; Ramiro AR; Jose ES; Alarcon B; Alibaud L; Rubin B; Toribio ML; Regueiro JR; Inmunologia, Facultad de Medicina, Universidad Complutense,; 28040 Madrid, Spain.; Mature CD4(+) and CD8(+) T lymphocytes are believed to build and express essentially identical surface alphabeta T-cell receptor-CD3 (TCR.CD3) complexes. However, TCR.CD3 expression has been shown to be more impaired in CD8(+) cells than in CD4(+) cells when CD3gamma is absent in humans or mice. We have addressed this
Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.: J Biol Chem. 2000 Jan 7;275(1):279-87. Unique Identifier : AIDSLINE MED/20085043; O'Keeffe B; Fong Y; Chen D; Zhou S; Zhou Q; Department of Molecular Biology, University of California at; Berkeley, Berkeley, California 94720-3206, USA.; Tat activation of HIV-1 transcription is mediated by human transcription elongation factor P-TEFb, which interacts with Tat and phosphorylates the C-terminal domain of RNA polymerase II. The catalytic subunit of the P-TEFb complex, Cdk9, has been shown to interact with cyclin T and several other proteins of unknown id
Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.: J Biol Chem. 2000 Jan 7;275(1):359-66. Unique Identifier : AIDSLINE MED/20085053; Klarmann GJ; Smith RA; Schinazi RF; North TW; Preston BD; Department of Biochemistry, Eccles Institute of Human Genetics,; Salt Lake City, Utah 84112, USA.; Studies of drug-resistant reverse transcriptases (RTs) reveal the roles of specific structural elements and amino acids in polymerase function. To characterize better the effects of RT/template interactions on dNTP substrate recognition, we examined the sensitivity of human immunodeficiency virus type 1 (HIV-1) RT con
Nucleoprotein gene tracking: localization of specific HIV-1 genes to subchromatin nucleoprotein complexes containing endonuclease activity in HIV-1-infected human cells.: J Cell Biochem. 1999;Suppl 32-33:158-65. Unique Identifier : AIDSLINE MED/20094854; Nicolson NL; Nicolson GL; Institute for Molecular Medicine, Huntington Beach, California; 92649, USA.; We developed a technique with which to isolate specific subchromatin deoxyribonucleoprotein/ribonucleoprotein precursor complexes containing discrete genes from intact mammalian nuclei by direct restriction enzyme treatment with MspI. These nucleoprotein complexes can be further fractionated and purified by two-dimens
HIV-induced T-cell syncytia release a two component T-helper cell chemoattractant composed of Nef and Tat.: J Cell Sci. 1999 Nov;112 ( Pt 22):3931-41. Unique Identifier : AIDSLINE MED/20016349; Shutt DC; Soll DR; Department of Biological Sciences, University of Iowa, Iowa City,; Iowa 52242, USA.; Using a newly developed gradient chamber to provide independent measurements of chemokinesis (stimulated motility) and chemotaxis (stimulated motility up a concentration gradient) of individual T-helper cells, it was recently demonstrated that HIV-induced T-cell syncytia release two distinct chemotactic activities tha
Personality changes in an i.v. drug abuser.: Hosp Pract (Off Ed). 2000 Jan 15;35(1):27-30. Unique Identifier : AIDSLINE MED/20111455; Koche LS; Eisner T; Shah RP; Adelman HM; University of South Florida, James A. Haley Veterans Hospital,; Tampa, USA.
Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use.: J Clin Endocrinol Metab. 2000 Jan;85(1):35-41. Unique Identifier : AIDSLINE MED/20097826; Hadigan C; Corcoran C; Stanley T; Piecuch S; Klibanski A; Grinspoon S; Neuroendocrine Unit, Massachusetts General Hospital and Harvard; Medical School, Boston, 02114, USA.; Fat redistribution in the setting of protease inhibitor use is increasingly common and is associated with insulin resistance in human immunodeficiency virus (HIV)-infected patients. However, little is known regarding the factors that may contribute to abnormal insulin regulation in this population. We assessed fasting
Effects of hypogonadism and testosterone administration on depression indices in HIV-infected men.: J Clin Endocrinol Metab. 2000 Jan;85(1):60-5. Unique Identifier : AIDSLINE MED/20097830; Grinspoon S; Corcoran C; Stanley T; Baaj A; Basgoz N; Klibanski A; Neuroendocrine Unit, Massachusetts General Hospital and Harvard; Medical School, Boston 02114, USA.; Hypogonadism is prevalent among human immunodeficiency virus-infected men, in whom significantly reduced quality of life and mood disturbances have been reported. Previous studies have not investigated the relationship between depression score and gonadal function among such patients. We first compared depression scor
The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism.: J Clin Endocrinol Metab. 2000 Jan;85(1):66-70. Unique Identifier : AIDSLINE MED/20097831; Yesilova Z; Ozata M; Kocar IH; Turan M; Pekel A; Sengul A; Ozdemir IC; Department of Internal Medicine, Gulhane School of Medicine,; Etlik-Ankara, Turkey.; There is a significant line of evidence for a role of androgens in the modulation of the immune system. However, little is known about immunological features of male patients with idiopathic hypogonadotropic hypogonadism (IHH) and the potential effects of gonadotropin treatment. Thus, the objective of this study was t
CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP.: J Neuroimmunol. 2000 Jan 3;102(1):1-7. Unique Identifier : AIDSLINE MED/20090086; Matsuoka E; Usuku K; Jonosono M; Takenouchi N; Izumo S; Osame M; Division of Molecular Pathology and Genetic Epidemiology, Center; for Chronic Virus Diseases, Faculty of Medicine, Kagoshima; University, Japan.; Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu
CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS.: J Neuroimmunol. 2000 Jan 3;102(1):44-50. Unique Identifier : AIDSLINE MED/20090091; Becher B; Blain M; Antel JP; Department of Microbiology, Dartmouth Medical School, Lebanon, NH; 03576, USA. burkhard.becher@dartmouth.edu; The APC-derived cytokine interleukin (IL)-12 polarizes CD4 T cells towards the pro-inflammatory Th1 phenotype and has been shown to be crucial for the development of EAE in rodents. In this study we demonstrate that production of IL-12 by human adult CNS-derived microglial cells can be triggered by cell contact with a
Intrathecal immune activation is associated with cerebrospinal fluid markers of neuronal destruction in AIDS patients.: J Neuroimmunol. 2000 Jan 3;102(1):51-5. Unique Identifier : AIDSLINE MED/20090092; Hagberg L; Fuchs D; Rosengren L; Gisslen M; Department of Infectious Diseases, Goteborg University,; Sahlgrenska University Hospital, Sweden.; lars.hagberg@medfak.gu.se; We analysed the relationship between cerebrospinal fluid (CSF) concentrations of the light subunit of the neurofilament protein (NFL, a marker of neurons, mainly axons), neopterin (a marker of immune activation), and quantitative HIV RNA levels in 47 patients with HIV-1 infection, 25 of whom had AIDS. In the AIDS pati
Behavioral and psychological disorders in uninfected children aged 6 to 11 years born to human immunodeficiency virus-seropositive mothers.: Unique Identifier : AIDSLINE MED/20074049; Esposito S; Musetti L; Musetti MC; Tornaghi R; Corbella S; Massironi E; Marchisio P; Guareschi A; Principi N; Paediatric Department IV, University of Milan, Italy.; This study investigated the behavioral and psychological differences between 39 uninfected children born to human immunodeficiency virus (HIV)-seropositive mothers (HIV-seroreverter [SR]) and 78 children with no family history of HIV infection. Caretakers completed the Child Behavior Checklist and the Gittelman modifi
Cyclin D1 expression and HHV8 in Kaposi sarcoma.: J Clin Pathol. 1999 Aug;52(8):569-73. Unique Identifier : AIDSLINE MED/20109820; Kennedy MM; Biddolph S; Lucas SB; Howells DD; Picton S; McGee JO; Silva I; Uhlmann V; Luttich K; O'Leary JJ; Nuffield Department of Pathology and Bacteriology, University of; Oxford, UK.; BACKGROUND: Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins which are pivotal in cell cycle progression. Recent HHV8 genetic analysis has revealed the presence of a v-cyclin which
Protease inhibitor-associated angiolipomatosis.: J Am Acad Dermatol. 2000 Jan;42(1 Pt 1):129-31. Unique Identifier : AIDSLINE MED/20082911; Dank JP; Colven R; Department of Medicine, Division of Dermatology, University of; Washington-Harborview Medical Center, Seatle 98104, USA.; Treatment with protease inhibitors in some persons infected with HIV-1 is associated with a syndrome of lipodystrophy manifesting as peripheral lipoatrophy, relative central adiposity, insulin resistance, and serum lipid abnormalities. We report 3 cases of HIV-1 inf
[Cystoid macular edema and cytomegalovirus retinitis in AIDS patients treated with antiretroviral triple therapy]: J Fr Ophtalmol. 1999 Dec;22(10):1034-41. Unique Identifier : AIDSLINE MED/20085207; Badelon I; Gohier P; Chaine G; Service d'Ophtalmologie, Hopital Avicenne 125, route de; Stalingrad, 93009 Bobigny Cedex.; AIM OF THE STUDY: This study evaluated cystoid macular edema (CME) occurring during inactive cytomegalovirus ( CMV ) retinitis, in AIDS patients treated with highly active antiretroviral therapy (HAART) and without anti CMV tre
[Cytomegalovirus retinitis and ocular complications in AIDS patients in Togo]: J Fr Ophtalmol. 1999 Dec;22(10):1042-6. Unique Identifier : AIDSLINE MED/20085208; Balo KP; Amoussou YP; Bechetoille A; Mihluedo H; Djagnikpo PA; Akpandja SM; Banla M; Service d'Ophtalmologie, CHU Tokoin, Lome, Togo.; komibalo@syfed.tg.refer.org; BACKGROUND: Cytomegalovirus retinitis seems to be an uncommon complication in African AIDS patients. This study was conducted in 200 patients in order to evaluate AIDS eye related complications with specific focus to cytomegalovirus retinitis. MATERIAL AND METHODS: During a period
Effects of oral nutritional supplementation on the intestinal mucosa of patients with AIDS.: J Clin Gastroenterol. 1999 Jan;30(1):77-80. Unique Identifier : AIDSLINE MED/20100171; Fogaca H; Souza H; Carneiro AJ; Carvalho AT; Pimentel ML; Papelbaum M; Elia P; Elia C; Multidisciplinary Laboratory, University Hospital, Federal; University of Rio de Janeiro, Brazil.; Weight loss is a major component of the clinical syndrome in patients with acquired immunodeficiency syndrome (AIDS). The impact of malnutrition on the outcome of the disease has been unappreciated in many investigations. The authors evaluated the effects of oral nutritional supplementation on the morphology and immun
New approaches to screening for cervical cancer in high-risk populations [editorial; comment]: J Lab Clin Med. 2000 Jan;135(1):12-3. Unique Identifier : AIDSLINE MED/20102226; Miller DM; Castillos FA
Infrared spectroscopic study of cervical smears in patients with HIV: implications for cervical carcinogenesis [see comments]: J Lab Clin Med. 2000 Jan;135(1):26-31. Unique Identifier : AIDSLINE MED/20102229; Rigas B; LaGuardia K; Qiao L; Bhandare PS; Caputo T; Cohenford MA; Department of Medicine, Cornell University Medical College, New; York, New York, USA.; Patients with HIV have an increased incidence of cervical cancer, necessitating increased surveillance. Infrared spectroscopy (IRS) has the potential of aiding the diagnosis of cervical neoplasia and also of providing clues into its pathogenesis. We studied by IRS cervical scrapings from 22 HIV-infected and 23 control
Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice.: J Exp Med. 1999 Dec 20;190(12):1857-68. Unique Identifier : AIDSLINE MED/20069893; Dittmer D; Stoddart C; Renne R; Linquist-Stepps V; Moreno ME; Bare C; McCune JM; Ganem D; Department of Microbiology, University of California, San; Francisco, California 94143, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV/HHV-8) is a novel human lymphotropic herpesvirus linked to several human neoplasms. To date, no animal model for infection by this virus has been described. We have examined the susceptibility of C.B-17 scid/scid mice implanted with human fetal thymus and liver grafts (SCI
Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis.: J Nat Prod. 1999 Nov;62(11):1510-3. Unique Identifier : AIDSLINE MED/20048034; Yang XW; Zhao J; Cui YX; Liu XH; Ma CM; Hattori M; Zhang LH; National Laboratory of Natural and Biomimetic Drugs, Beijing; Medical University, Beijing 100083, People's Republic of China.; xwyang@mail.bjmu.edu.cn; Eight bioactive triterpenoid saponins (1-8) were isolated from the seeds of Aesculus chinensis, four of which are novel compounds. The major saponins were identified as escin Ia (1), Ib (2), isoescin Ia (3) and Ib (4), while the new compounds were identified as 22alpha-tigloyl-28-acetylprotoaescigenin-3beta-O-:beta D-
Increased cerebrospinal fluid protein tau concentration in neuro-AIDS.: J Neurol Sci. 1999 Dec 15;171(2):92-6. Unique Identifier : AIDSLINE MED/20050808; Andersson L; Blennow K; Fuchs D; Svennerholm B; Gisslen M; Institute of Internal Medicine, Department of Infectious; Diseases, Goteborg University, Sahlgrenska University Hospital,; S-416 85, Goteborg, Sweden. lars-magnus.andersson@medfak.gu.se; OBJECTIVES: Assessment of cerebrospinal fluid (CSF) levels of protein tau in human immunodeficiency virus type 1 (HIV-1) infection. MATERIAL AND METHODS: CSF tau levels were analyzed in 52 HIV-1-infected patients, 37 of whom had no neurological symptoms, eight had aquired immunodeficiency syndrome (AIDS)
Respiratory infections in patients with HIV.: J R Coll Physicians Lond. 1999 Sep-Oct;33(5):430-3. Unique Identifier : AIDSLINE MED/20089782; Breen R; Johnson M; Department of HIV and Thoracic Medicine, Royal Free Hospital,; London.
Cessation of antiretroviral therapy and rapid rebound of HIV.: J Natl Med Assoc. 1999 Dec;91(12):645-6. Unique Identifier : AIDSLINE MED/20093609
HIV post-exposure therapy for drug users in treatment.: J Subst Abuse Treat. 2000 Jan;18(1):17-21. Unique Identifier : AIDSLINE MED/20100557; O'Connor PG; Department of Internal Medicine and the Substance Abuse Treatment; Unit, Yale University School of Medicine, Primary Care Center and; Yale-New Haven Hospital, New Haven, CT 06520-8025, USA.; patrick.oconnor@yale.edu; The purpose of this study was to evaluate the attitudes of drug treatment program providers concerning human immunodeficiency virus (HIV) post-exposure therapy (PET) for drug users enrolled in drug treatment. This was a cross-sectional evaluation of drug treatment program providers in four methadone maintenance progra
Home sample collection for HIV testing [letter]: JAMA. 2000 Jan 12;283(2):198-9. Unique Identifier : AIDSLINE MED/20097796; Phillips KA; Morin S; Coates T; Fernyak S; Marsh A; Ramos-Irizarry L
Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. Trilege (Agence Nationale de Recherches sur le SIDA 072) Study Team) [see comments]: JAMA. 2000 Jan 12;283(2):205-11. Unique Identifier : AIDSLINE MED/20097802; Descamps D; Flandre P; Calvez V; Peytavin G; Meiffredy V; Collin G; Delaugerre C; Robert-Delmas S; Bazin B; Aboulker JP; Pialoux G; Raffi F; Brun-Vezinet F; Hopital Bichat-Claude Bernard, Paris, France.; CONTEXT: In the Trilege trial, following induction with a zidovudine, lamivudine, and indinavir regimen, human immunodeficiency virus (HIV) replication was less suppressed by 2-drug maintenance therapy than by triple-drug therapy. OBJECTIVE: To identify mechanisms of virologic failure in the 3 arms of the Trilege tria
Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens [see comments]: JAMA. 2000 Jan 12;283(2):229-34. Unique Identifier : AIDSLINE MED/20097805; Havlir DV; Hellmann NS; Petropoulos CJ; Whitcomb JM; Collier AC; Hirsch MS; Tebas P; Sommadossi JP; Richman DD; University of California, San Diego 92103, USA. dhavlir@ucsd.edu; CONTEXT: Loss of viral suppression in patients infected with human immunodeficiency virus (HIV), who are receiving potent antiretroviral therapy, has been attributed to outgrowth of drug-resistant virus; however, resistance patterns are not well characterized in patients whose protease inhibitor
Resistance, fitness, adherence, and potency: mapping the paths to virologic failure [editorial; comment]: JAMA. 2000 Jan 12;283(2):250-1. Unique Identifier : AIDSLINE MED/20097808; Markowitz M
[Factors for the onset of and the exacerbation of tuberculosis. 2. Host factors promoting the occurrence and exacerbation of tuberculosis: significance of Th1-Th2 cytokine balance]: Kekkaku. 1999 Oct;74(10):735-40. Unique Identifier : AIDSLINE MED/20030372; Kawakami K; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; The problem of tuberculosis is emerging again with increase in the population of aged people and immunocompromised patients in Japan . It has been well documented that cell-mediated immunity play a central role in host resistance to infection with Mycobacterium tuberculosis. A decade
[Factors for the onset of and the exacerbation of tuberculosis. 5. The infection and prognosis of tuberculosis among patients with immunodeficiency, especially HIV-infected patients]: Kekkaku. 1999 Oct;74(10):753-8. Unique Identifier : AIDSLINE MED/20030375; Nagai H; Department of Respiratory Diseases, National Tokyo Hospital,; Japan.; The number of people infected with human immunodeficiency virus (HIV) is gradually increasing in Japan , and the morbidity rate from tuberculosis in the Japanese people is high. Accordingly, the number of cases with both infections is considered to increase in the future. Our hospita
Second treatment with fludarabine in a Waldenstrom's macroglobulinemia patient [letter]: Leukemia. 2000 Jan;14(1):220. Unique Identifier : AIDSLINE MED/20105442; Maloisel F; Campos F; Giron C; Dufour P
Prevalence and predictors of unmet need for supportive services among HIV-infected persons: impact of case management.: Med Care. 2000 Jan;38(1):58-69. Unique Identifier : AIDSLINE MED/20094416; Katz MH; Cunningham WE; Mor V; Andersen RM; Kellogg T; Zierler S; Crystal SC; Stein MD; Cylar K; Bozzette SA; Shapiro MF; Department of Public Health, San Francisco, California, USA.; BACKGROUND: Previous research has indicated that the needs of persons infected with human immunodeficiency virus (HIV) for supportive services often go unmet. Although case management has been advocated as a method of decreasing unmet needs for supportive services, its effectiveness is poorly understood. OBJECTIVES: T
[What to do after accidental exposure to blood or other biological fluids in the health care medium]: Med Clin (Barc). 1999 Oct 30;113(14):544-8. Unique Identifier : AIDSLINE MED/20073606; Torres M; Campins M; Serra C; Martinez M; Bruguera M; Servicio de Medicina Interna, Hospital de l'Esperit Sant, Santa; Coloma de Gramenet, Barcelona.
[Cryoglobulinemia and hepatitis C virus infection in patients with monoclonal gammopathies (letter)]: Med Clin (Barc). 1999 Oct 30;113(14):558. Unique Identifier : AIDSLINE MED/20073611; Domingo JM; Soledad Romero M; Palomera L; Gutierrez M
[Inappropriate presentation of pharmaceutical forms of dosages in antiretroviral therapy (letter)]: Med Clin (Barc). 1999 Oct 30;113(14):559. Unique Identifier : AIDSLINE MED/20073612; Gonzalez Delgado M; Anton Torres R; Borras Blasco J; Ortiz de Urbina Sandomingo V
[Prognostic markers of survival in infants younger than 12 month of age vertically infected by human immunodeficiency virus]: Med Clin (Barc). 1999 Nov 6;113(15):561-6. Unique Identifier : AIDSLINE MED/20073613; Resino S; Jimenez JL; Gurbindo D; Munoz-Fernandez MA; Servicio de Inmunologia, Hospital General Universitario Gregorio; Maranon, Madrid.; OBJECTIVES: To assess the immunological and virological markers as potential predictors of progression to death in HIV-1 infected
[AIDS and children (editorial)]: Med Clin (Barc). 1999 Nov 6;113(15):575-7. Unique Identifier : AIDSLINE MED/20073616; Delgado Garcia-Campero A
[Many epoch-making discoveries--but also big misjudgements]: Lakartidningen. 1999 Dec 22;96(51-52):5744-52. Unique Identifier : AIDSLINE MED/20107871; Stolt CM; Humanistisk medicin, Karolinska institutet, Stockholm.
Using protein structural information in evolutionary inference: transmembrane proteins.: Mol Biol Evol. 1999 Dec;16(12):1696-710. Unique Identifier : AIDSLINE MED/20073038; Lio P; Goldman N; Department of Genetics, University of Cambridge, England.; We present a model of amino acid sequence evolution based on a hidden Markov model that extends to transmembrane proteins previous methods that incorporate protein structural information into phylogenetics. Our model aims to give a better understanding of processes of molecular evolution and to extract structural info
hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.: Mol Cell Biol. 1999 Oct;19(10):6833-44. Unique Identifier : AIDSLINE MED/99421967; Kim MK; Nikodem VM; Genetics and Biochemistry Branch, National Institute of Diabetes; and Digestive and Kidney Diseases, National Heart, Lung, and; Blood Institute, National Institutes of Health, Bethesda, MD; 20892, USA. kimm@gwgate.nhlbi.nih.gov; This study describes a potential new function of hnRNP U as an RNA polymerase (Pol II) elongation inhibitor. We demonstrated that a subfraction of human hnRNP U is associated with the Pol II holoenzyme in vivo and as such recruited to the promoter as part of the preinitiation complex. hnRNP U, however, appears to diss
Assessing the replicative history of human T cells [see comments]: Mutat Res. 1999 Dec 17;431(2):177-80. Unique Identifier : AIDSLINE MED/20101923; Van Lier RA; Baars PA; Department of Immunobiology, CLB, Academic Medical Centre,; Plesmanlaan, Amsterdam, Netherlands. r_van_lier@clb.nl; Upon encountering antigen, T cells clonally expand and differentiate into effector cells that directly or indirectly eliminate antigen-bearing pathogens. When renewed contact with the same pathogen occurs the immune response is mounted in a faster and more accurate way, a process that is referred to as immunological m
Transmission of Mycobacterium tuberculosis from a cadaver to an embalmer.: N Engl J Med. 2000 Jan 27;342(4):246-8. Unique Identifier : AIDSLINE MED/20098056; Sterling TR; Pope DS; Bishai WR; Harrington S; Gershon RR; Chaisson RE; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore City Health Department Eastern Chest; Clinic, MD, USA. tsterls@jhmi.edu
Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus.: Ophthalmology. 2000 Jan;107(1):159-63. Unique Identifier : AIDSLINE MED/20112261; Feinberg AS; Spraul CW; Holden JT; Grossniklaus HE; Department of Ophthalmology, Emory University School of Medicine,; Atlanta, Georgia, USA.; PURPOSE: To describe the clinicopathologic features of two patients with Epstein-Barr virus (EBV) associated conjunctival lymphocytic infiltrates. DESIGN: Two case reports. METHODS: The clinical histories and pathologic findings of two patients with salmon-colored conjunctival infiltrates are described. MAIN OUTCOME M
Green tea and its major components ameliorate immune dysfunction in mice bearing Lewis lung carcinoma and treated with the carcinogen NNK.: Nutr Cancer. 1999;35(1):64-72. Unique Identifier : AIDSLINE MED/20089834; Zhu M; Gong Y; Yang Z; Ge G; Han C; Chen J; Institute of Radiation Medicine, Beijing, China.; yfg268@nic.bmi.ac.cn; The protective effects of tea and/or its components on dysfunction of immune functions during tumor growth and carcinogenesis in mice were studied using two experimental models: C57/BL6J mice transplanted with Lewis lung carcinoma (LLC) and Kunming mice treated with a single dose of 4-(methylnitrosamino-)-1-(3-pyridyl
Concentration-dependent differential induction of necrosis or apoptosis by HIV-1 lytic peptide 1.: Peptides. 1999 Nov;20(11):1275-83. Unique Identifier : AIDSLINE MED/20077688; Plymale DR; Comardelle AM; Fermi CD; Martin DS; Costin JM; Norris CH; Tencza SB; Mietzner TA; Montelaro RC; Garry RF; Interdisciplinary Graduate Program in Molecular and Cellular; Biology, Tulane University, New Orleans, LA 70112, USA.; The mechanism by which human immunodeficiency virus type 1 induces depletion of CD4+ T-lymphocytes remains controversial, but may involve cytotoxic viral proteins. Synthetic peptides (lentivirus lytic peptide type 1) corresponding to the carboxyl terminus of the human immunodeficiency virus type 1 transmembrane glycop
Expression of cannabinoid receptors and their gene transcripts in human blood cells.: Prog Neuropsychopharmacol Biol Psychiatry. 1999 Aug;23(6):1063-77. Unique Identifier : AIDSLINE MED/20087830; Onaivi ES; Chaudhuri G; Abaci AS; Parker M; Manier DH; Martin PR; Hubbard JR; Department of Psychiatry, Vanderbilt University School of; Medicine, Nashville, TN, USA. Emmanuel.S.Onaivi@Vanderbilt.edu; 1. This study shows that the human cannabinoid receptors and their gene transcripts can be analyzed in blood samples when combined with polymerase chain reaction. The results also demonstrate that the expression of the cannabinoid receptors is dependent on gender and ethnic background. 2. Normal human volunteers who d
[Hyperlipidemia in patients with HIV infection treated with protease inhibitors (letter)]: Rev Clin Esp. 1999 Nov;199(11):780-1. Unique Identifier : AIDSLINE MED/20103608; Lopez Garcia F; Mora Rufete A; Escolano Hortelano CM; Gutierrez Rodero F
Pulmonary complications of HIV disease. Introduction.: Semin Respir Infect. 1999 Dec;14(4):299-300. Unique Identifier : AIDSLINE MED/20102046; Rosen MJ
Epidemiology and risk of pulmonary disease.: Semin Respir Infect. 1999 Dec;14(4):301-8. Unique Identifier : AIDSLINE MED/20102047; Rosen MJ; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, and Albert Einstein College of Medicine, New; York, New York 10003, USA.; Although pulmonary diseases are important causes of illness and death in patients with human immunodeficiency virus (HIV) infection, advances in treatment and the demographics of HIV-infected populations are changing their incidence and manifestations. The rates of acquires immune deficiency syndrome (AIDS)- related m
Screening and noninvasive testing for pulmonary disease.: Semin Respir Infect. 1999 Dec;14(4):309-17. Unique Identifier : AIDSLINE MED/20102048; Schneider RF; Medical Intensive Care Unit, Beth Israel Medical Center, Albert; Einstein College of Medicine, New York, New York 10003, USA.; Although detection of preclinical disease using screening tests is desirable if earlier treatment improves outcome, the available data show no morbidity or mortality benefit using chest radiography, sputum analysis for Pneumocystis carinii and acid-fast bacilli, or serial measurements of single-breath carbon monoxide
Bronchoscopic techniques for the diagnosis of pulmonary complications of HIV infection.: Semin Respir Infect. 1999 Dec;14(4):318-26. Unique Identifier : AIDSLINE MED/20102049; Salzman SH; Division of Pulmonary Critical Care Medicine, Beth Israel Medical; Center, Albert Einstein College of Medicine, New York, New York; 10003, USA.; Bronchoscopy has played the central role in defining the spectrum of pulmonary disorders that occur in patients with HIV infection. Transbronchial biopsy (TBB) and bronchoalveolar lavage (BAL) both have high yields in the diagnosis of Pneumocystis carinii pneumonia (PCP) and other infections. Paradoxically, despite ou
Bacterial pneumonia.: Semin Respir Infect. 1999 Dec;14(4):327-32. Unique Identifier : AIDSLINE MED/20102050; Schneider RF; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, Albert Einstein College of Medicine, New York,; New York 10003, USA.; Bacterial pneumonia is significantly more common in persons who are HIV-infected than in the general population and is most common among injection drug users and in persons with advanced HIV disease and immunosuppression. The clinical features of bacterial pneumonia are similar to those in HIV-seronegative persons, bu
Pneumocystis carinii pneumonia.: Semin Respir Infect. 1999 Dec;14(4):333-43. Unique Identifier : AIDSLINE MED/20102051; Schliep TC; Yarrish RL; Division of Infectious Diseases, Beth Israel Medical Center,; Albert Einstein College of Medicine, New York, New York 10003,; USA.; Throughout the epidemic, Pneumocystis carinii pneumonia (PCP) has been the most common AIDS-defining opportunistic infection in the United States . With the widespread use of highly active antiretroviral therapy (HAART) and prophylaxis in patients known to be at risk, the incidence of P
Tuberculosis in patients with human immunodeficiency virus infection.: Semin Respir Infect. 1999 Dec;14(4):344-52. Unique Identifier : AIDSLINE MED/20102052; Perlman DC; El-Helou P; Salomon N; AIDS Inpatient Unit, Beth Israel Medical Center, Albert Einstein; College of Medicine, New York, New York 10003, USA.; Tuberculosis (TB) is the major opportunistic infection of human immunodeficiency virus (HIV)-infected persons worldwide. Human immunodeficiency virus infection is the most potent known risk factor for reactivation of latent Mycobacterium tuberculosis infection, and TB disease appears to increase the rate of HIV progre
Cytomegalovirus pneumonia.: Semin Respir Infect. 1999 Dec;14(4):353-8. Unique Identifier : AIDSLINE MED/20102053; Salomon N; Perlman DC; Division of Infectious Diseases, Beth Israel Medical Center,; Albert Einstein College of Medicine, New York, New York 10003,; USA.; Cytomegalovirus ( CMV ) pneumonia is a major cause of morbidity and mortality in allogeneic bone marrow transplant and lung transplant recipients. However, its role as a cause of lung disease in patients with the human immunodeficiency virus (HIV) is controversial
Thoracic surgical spectrum of HIV infection.: Semin Respir Infect. 1999 Dec;14(4):359-65. Unique Identifier : AIDSLINE MED/20102054; Abolhoda A; Keller SM; Beth Israel Medical Center, Albert Einstein College of Medicine,; New York, New York 10003, USA.; The thoracic surgeon is often called on to diagnose or treat a variety of disorders associated with human immunodeficiency virus (HIV) infection. Surgical mediastinal exploration through cervical and anterior approaches is a safe and valuable modality in appropriately selected patients with unexplained mediastinal lym
Intensive care of patients with HIV infection.: Semin Respir Infect. 1999 Dec;14(4):366-71. Unique Identifier : AIDSLINE MED/20102055; Rosen MJ; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, Albert Einstein College of Medicine, New York,; New York 10003, USA.; Despite the improvements in the prognosis associated with the development of highly active antiretroviral therapy (HAART), more than 410,000 people in the United States were reported to have died from acquired immune deficiency syndrome (AIDS) by the end of 1998. The number of people l
Infection control in pulmonary and critical care medicine.: Semin Respir Infect. 1999 Dec;14(4):372-82. Unique Identifier : AIDSLINE MED/20102056; Raucher BG; Department of Infection Control, Beth Israel Medical Center, New; York, New York 10003, USA.; During the routine care of patients, pulmonary and critical care specialist may have significant exposure to respiratory infections and potentially infectious body fluids such as blood and pleural fluid. Bronchoscopy and intensive care services often require close contact with patients and the use of sharp devices req
[1977 mortality rate in HIV-infected patients presenting with hepatitis C cirrhosis. Results of the GERMIVC multicenter survey conducted in French departments of internal medicine or infectious disease]: Rev Med Interne. 1999 Dec;20(12):1082-7. Unique Identifier : AIDSLINE MED/20100986; Geffray L; Rosenthal E; Cacoub P; Perronne C; Veyssier P; Raguin G; Cevallos R; Patey O; Bouchard O; Loury I; Delarocque E; Goujard C; Estavoyer JM; Dupont C; Grappin M; Morand P; Laurichesse H; Vuitton D; Hopital de Compiegne, Nice, France.; PURPOSE: Hepatitis C (HCV) has a high prevalence (10-30%) among human immunodeficiency virus (HIV)-infected patients. However, little information is available regarding the impact of hepatitis C on survival. The objective of our study was to determine the incidence of hepatitis C-related deaths in HIV-HCV co-infected
[Pain in the left scapula]: Schweiz Rundsch Med Prax. 1999 Nov 18;88(47):1958-9. Unique Identifier : AIDSLINE MED/20073256; Guex AC; Departement Innere Medizin, Kantonsspital Basel.
[Diarrhea in HIV infection]: Schweiz Rundsch Med Prax. 1999 Dec 9;88(50):2081-2. Unique Identifier : AIDSLINE MED/20107939; Hansel A; Medizinische Universitats-Poliklinik Basel.
Histologic lesions in cynomolgus monkeys (Macaca fascicularis) naturally infected with simian retrovirus type D: comparison of seropositive, virus-positive, and uninfected animals.: Toxicol Pathol. 1999 Nov-Dec;27(6):672-7. Unique Identifier : AIDSLINE MED/20053769; Guzman RE; Kerlin RL; Zimmerman TE; Drug Safety Evaluation, Pfizer Central Research, Groton,; Connecticut 06340, USA. reguzman@students.uiuc.edu; Simian retrovirus (SRV) type D is a common cause of simian acquired immunodeficiency syndrome (SAIDS), a usually fatal immunosuppressive disease of macaques. Associated gross and histologic lesions have been well described for the rhesus macaque (Macaca mulatta) in experimental and natural infections. However, morphol
[Grotesque hepatomegaly in known HIV seropositivity]: Schweiz Med Wochenschr. 1999 Dec 4;129(48):1902. Unique Identifier : AIDSLINE MED/20093468; Sanna P; Spataro V; Fadini D; Cavalli F; Istituto Oncologico della Svizzera Italiana, Divisione di; Oncologia medica, Ospedale San Giovanni, Bellinzona.; oncosg@siak.ch
Of chimps and men [letter]: Science. 2000 Jan 14;287(5451):233. Unique Identifier : AIDSLINE MED/20119943; Hooper E
The last resort would be to go to the GP'. Understanding the perceptions and use of general practitioner services among people with HIV/AIDS.: Soc Sci Med. 2000 Jan;50(2):233-45. Unique Identifier : AIDSLINE MED/20084710; Petchey R; Farnsworth B; Williams J; Division of General Practice, University of Nottingham, Queen's; Medical Centre, UK. roland.petchey@nottingham.ac.uk; In England and Wales, departments of Genito-Urinary Medicine have led the clinical response to HIV infection and AIDS (HIV/AIDS). They provide an open-access self-referral service on a basis of strict confidentiality. People with HIV/AIDS have been found to be reluctant to involve their general practitioner (GP) in th
[Experience in the management of the HIV patient among the physicians of the Secretaria de Salud]: Salud Publica Mex. 1999 Nov-Dec;41(6):460-5. Unique Identifier : AIDSLINE MED/20099893; Magis-Rodriguez C; Esquivel-Pedraza L; Lopez-Martinez C; Consejo Nacional para la Prevencion y el Control del SIDA; (CONASIDA), Mexico, D.F. magis@cenids.ssa.gob.mx; OBJECTIVE: To determine the experience of the National Health Ministry physicians in the management of HIV-infected patients and in the use of antiretrovirals. MATERIAL AND METHOD: A descriptive, observational and transversal study was performed, with support from the National AIDS Council from March to May 1998. Self
[The UNAIDS challenges for the next millennium and the participation of Mexico (news)]: Salud Publica Mex. 1999 Nov-Dec;41(6):492-4. Unique Identifier : AIDSLINE MED/20099898; Uribe Zuniga P
CD4+ T cell response to factor VIII in hemophilia A, acquired hemophilia, and healthy subjects.: Thromb Haemost. 1999 Aug;82(2):509-15. Unique Identifier : AIDSLINE MED/20073677; Reding MT; Wu H; Krampf M; Okita DK; Diethelm-Okita BM; Key NS; Conti-Fine BM; Department of Biochemistry, Molecular Biology and Biophysics,; University of Minnesota, Minneapolis/St. Paul 55108, USA.; These studies have begun to clarify the complex cellular mechanisms involved in the immune response to factor VIII. Although vigorous sensitization of CD4+ cells occurs in healthy subjects, the absence of clinically significant levels of inhibitor antibodies is likely related to the prompt down-regulation of the immun
[Prevention after accidental exposure to HIV (editorial)]: Ugeskr Laeger. 1999 Nov 29;161(48):6605. Unique Identifier : AIDSLINE MED/20107952; Skinhoj P
[Use of antiretroviral chemoprophylaxis after occupational HIV exposure]: Ugeskr Laeger. 1999 Nov 29;161(48):6619-21. Unique Identifier : AIDSLINE MED/20107957; Madsen KM; Gerstoft J; Kvinesdal BB; Nielsen HI; Moller A; Pedersen C; Obel N; Arhus Universitetshospital, Marselisborg Hospital, medicinsk; epidemisk afdeling A.; The study describes the use of postexposure antiretroviral prophylaxis (PEP) after occupational exposure to HIV in Denmark in the period 1/1 1997-31/12 1998. Forty-seven accidentally exposed persons received PEP in this period, of w
The primate lentivirus-encoded Nef protein can regulate several steps of the viral replication cycle.: Virology. 1999 Dec 20;265(2):173-7. Unique Identifier : AIDSLINE MED/20070307; Collette Y; Olive D; Universite de la Mediterranee, Marseille, 13009, France.; collette@marseille.inserm.fr; The primate lentiviruses encode a protein, Nef, which is required for efficient viral replication in their host. Several biological activities of nef identified in vitro may contribute to this requirement in vivo, including receptor modulation and interference with cellular signaling pathways. We show that HIV- and SI
SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques.: Virology. 1999 Dec 20;265(2):235-51. Unique Identifier : AIDSLINE MED/20070314; Mandell CP; Reyes RA; Cho K; Sawai ET; Fang AL; Schmidt KA; Luciw PA; Department of Medical Pathology, University of California, Davis,; California 95616, USA.; The simian immunodeficiency virus (SIV) nef gene is an important determinant of viral load and acquired immunodeficiency syndrome (AIDS) in macaques. A role(s) for the HIV-1 nef gene in infection and pathogenesis was investigated by constructing recombinant viruses in which the nef gene of the pathogenic molecular clo
Protection of macaques against a SHIV with a homologous HIV-1 Env and a pathogenic SHIV-89.6P with a heterologous Env by vaccination with multiple gene-deleted SHIVs.: Virology. 1999 Dec 20;265(2):252-63. Unique Identifier : AIDSLINE MED/20070315; Ui M; Kuwata T; Igarashi T; Ibuki K; Miyazaki Y; Kozyrev IL; Enose Y; Shimada T; Uesaka H; Yamamoto H; Miura T; Hayami M; Institute for Virus Research, Kyoto University, Kyoto, 606-8507,; Japan.; To evaluate the potential of SHIVs as anti-HIV-1 live vaccines, we constructed two gene-deleted SHIVs, designated SHIV-drn and SHIV-dxrn. The former lacks vpr/nef and the latter lacks vpx/vpr/nef. Four macaques that had been vaccinated with SHIV-drn were challenged with SHIV-NM-3rN, which has an HIV-1 Env that is the
A CXC chemokine receptor, CXCR5/BLR1, is a novel and specific coreceptor for human immunodeficiency virus type 2.: Virology. 1999 Dec 20;265(2):264-73. Unique Identifier : AIDSLINE MED/20070316; Kanbe K; Shimizu N; Soda Y; Takagishi K; Hoshino H; Department of Virology and Preventive Medicine, Gunma University; School of Medicine, 3-39-22 Showa-machi, Gunma, Maebashi,; 371-8511, Japan.; G protein-coupled receptors serve as coreceptors in the infection process of human immunodeficiency virus type-1 (HIV-1), type-2 (HIV-2), and simian immunodeficiency virus (SIV). In this study, we showed that a CXC-CKR, CXCR5/BLR1, is a novel coreceptor for HIV-2, but for neither HIV-1 nor SIV. The expression of CXCR5
Bovine leukemia virus Gag particle assembly in insect cells: formation of chimeric particles by domain-switched leukemia/lentivirus Gag polyprotein.: Virology. 1999 Dec 20;265(2):308-18. Unique Identifier : AIDSLINE MED/20070320; Kakker NK; Mikhailov MV; Nermut MV; Burny A; Roy P; Department of Biochemistry, University of Oxford, South Parks; Road, Oxford, OX1 3QU, United Kingdom.; A key stage in the life cycle of C-type retroviruses is the assembly of Gag precursor protein at the plasma membrane of infected cells. Here we report the assembly of bovine leukemia virus (BLV) gag gene product into virus-like particles (VLPs) using the baculovirus expression system. Expression of BLV Pr44(Gag) resul
Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes.: Virology. 1999 Dec 20;265(2):319-29. Unique Identifier : AIDSLINE MED/20070321; Carr JM; Hocking H; Li P; Burrell CJ; Infectious Diseases Laboratories, Institute of Medical and; Veterinary Science, Frome Road, Adelaide, 5000, South Australia.; jill.carr@imvs.sa.gov.au; Macrophages are considered of central importance in cell-to-cell transmission of human immunodeficiency virus (HIV) infection in vivo. In this report, we describe a novel cell-to-cell transmission model using HIV-infected monocyte-derived macrophages (MDMs) as donor cells and peripheral blood lymphocytes (PBLs) as rec
Glycans and proteoglycans are involved in the interactions of human immunodeficiency virus type 1 envelope glycoprotein and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells.: Virology. 1999 Dec 20;265(2):354-64. Unique Identifier : AIDSLINE MED/20070324; Mbemba E; Benjouad A; Saffar L; Gattegno L; JE 2138, Faculte de Medecine Leonard de Vinci, Bobigny, 93017,; France.; We demonstrate that human immunodeficiency virus HIV-1(LAI) envelope glycoprotein 120 (gp120(LAi)) specifically interacts with several membrane ligands on lymphoid CEM or monocytic U937 cells in addition to its previously identified receptor, CD4, and CXCR4, its coreceptor. In its native state, gp120(LAI) is able to e
Construction of infectious feline foamy virus genomes: cat antisera do not cross-neutralize feline foamy virus chimera with serotype-specific Env sequences.: Virology. 2000 Jan 5;266(1):150-6. Unique Identifier : AIDSLINE MED/20080982; Zemba M; Alke A; Bodem J; Winkler IG; Flower RL; Pfrepper K; Delius H; Flugel RM; Lochelt M; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, 69009, Germany.; Full-length genomes of the feline foamy virus (FFV or FeFV) isolate FUV were constructed. DNA clone pFeFV-7 stably directed the expression of infectious FFV progeny virus indistinguishable from wild-type, uncloned FFV isolate FUV. The env and bel 1 genes of pFeFV-7 were substituted for by corresponding sequences of th
Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication.: Unique Identifier : AIDSLINE MED/20080969; Chang J; Renne R; Dittmer D; Ganem D; Howard Hughes Medical Institute, University of California, San; Francisco, San Francisco, California, 94143-0414, USA.; Kaposi s sarcoma (KS) is a complex proliferative lesion long suspected of being dependent on exogenous paracrine signaling molecules to stimulate its proliferative, angiogenic, and inflammatory components. In particular, both clinical and experimental observations have pointed to a potential role for inflammatory cyto
Characterization of recombination events leading to the production of an ecotropic replication-competent retrovirus in a GP+envAM12-derived producer cell line.: Virology. 2000 Jan 5;266(1):170-9. Unique Identifier : AIDSLINE MED/20080984; Garrett E; Miller AR; Goldman JM; Apperley JF; Melo JV; Department of Haematology, Imperial College School of Medicine,; Hammersmith Hospital, Du Cane Road, London, W12 ONN, United; Kingdom.; Replication-competent retrovirus (RCR) was identified in a GP+envAM12-derived producer cell, containing the MFG-S-Neo retroviral vector, using a marker rescue assay. Studies were undertaken to determine the origin and structure of this RCR. Receptor interference assays demonstrated that the virus was pseudotyped with
Replication rate of feline immunodeficiency virus in astrocytes is envelope dependent: implications for glutamate uptake.: Virology. 2000 Jan 5;266(1):180-8. Unique Identifier : AIDSLINE MED/20080985; Billaud JN; Selway D; Yu N; Phillips TR; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, California, 92037, USA.; Feline immunodeficiency virus (FIV) induces neurological abnormalities in domestic cats. Previously, we demonstrated that two disparate strains of FIV (FIV-34TF10 and FIV-PPR) varied greatly in the ability to replicate in feline cortical astrocytes. To investigate the impact of the env region on the replication effici
Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.: Virology. 2000 Jan 5;266(1):203-10. Unique Identifier : AIDSLINE MED/20080988; Nixon DF; Donahoe SM; Kakimoto WM; Samuel RV; Metzner KJ; Gettie A; Hanke T; Marx PA; Connor RI; Aaron Diamond AIDS Research Center, The Rockefeller University,; 455 First Avenue, New York, New York, 10016, USA.; DNixon@ADARC.org; In this study, we examined the role of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes (CTLs) in macaques immunized with an attenuated strain of simian immunodeficiency virus (SIVmac239Deltanef) in protection against pathogenic challenge with SIVmac251. Our results indicate that attenuated SIVmac2
Synthesis in Escherichia coli of avian reovirus core protein varsigmaA and its dsRNA-binding activity.: Virology. 2000 Jan 5;266(1):33-41. Unique Identifier : AIDSLINE GENBANK/AF104311; Yin HS; Shien JH; Lee LH; Department of Veterinary Medicine, National Chung Hsing; University, Taichung, 403, Taiwan.; The genome segment S2 of p6ian reovirus (ARV) S1133 was cloned and sequenced. The entire S2 nucleotide sequence is 1325 bp long with one long open reading frame that encodes a protein of 415 amino acids, corresponding to varsigmaA, a major core protein of ARV. S2 possesses a pentanucleotide, TCATC, at the 3 -terminus
Actin-binding cellular proteins inside human immunodeficiency virus type 1.: Virology. 2000 Jan 5;266(1):42-51. Unique Identifier : AIDSLINE MED/20080972; Ott DE; Coren LV; Johnson DG; Kane BP; Sowder RC 2nd; Kim YD; Fisher RJ; Zhou XZ; Lu KP; Henderson LE; SAIC Frederick, National Cancer Institute, Frederick, Maryland,; 21702-1201, USA. ott@avpvx1.ncifcrf.gov; Host proteins are incorporated both on and inside human immunodeficiency virus type 1 (HIV-1) virions. To identify cellular proteins inside HIV-1, virion preparations were treated by a protease-digestion technique that removes external host proteins, allowing for the study of the proteins inside the virus. Treated HIV
Immunogenic and antigenic dominance of a nonneutralizing epitope over a highly conserved neutralizing epitope in the gp41 envelope glycoprotein of human immunodeficiency virus type 1: its deletion leads to a strong neutralizing response.: Virology. 2000 Jan 5;266(1):66-78. Unique Identifier : AIDSLINE MED/20080974; Cleveland SM; Buratti E; Jones TD; North P; Baralle F; McLain L; McInerney T; Durrani Z; Dimmock NJ; Department of Biological Sciences, University of Warwick,; Coventry, CV4 7AL, United Kingdom.; The Kennedy peptide, (731)PRGPDRPEGIEEEGGERDRDRS(752), from the cytoplasmic domain of the gp41 transmembrane envelope glycoprotein of HIV-1 contains a conformationally dependent neutralizing epitope (ERDRD) and a linear nonneutralizing epitope (IEEE). No recognized murine T cell epitope is present. The peptide usually
Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays.: Virology. 2000 Jan 5;266(1):8-16. Unique Identifier : AIDSLINE MED/20080968; Geiss GK; Bumgarner RE; An MC; Agy MB; van 't Wout AB; Hammersmark E; Carter VS; Upchurch D; Mullins JI; Katze MG; Department of Microbiology, School of Medicine, Seattle,; Washington, 98195, USA.; Human immunodeficiency virus type 1 (HIV-1) infection alters the expression of host cell genes at both the mRNA and protein levels. To obtain a more comprehensive view of the global effects of HIV infection of CD4-positive T-cells at the mRNA level, we performed cDNA microarray analysis on approximately 1500 cellular
Inoculation injuries in hospitals in Trinidad and Tobago.: West Indian Med J. 1999 Dec;48(4):227-30. Unique Identifier : AIDSLINE MED/20104040; Chadee DD; Edwards JR; Sharma K; Shivnath B; Trinidad Public Health Laboratory, Port of Spain, Trinidad and; Tobago.; This paper reviews the frequency of inoculation injuries, which occurred in hospitals in Trinidad and Tobago from 1991 to 1997, inclusive. A tota
In vitro immune function after vaccination with an inactivated, gp120-depleted HIV-1 antigen with immunostimulatory oligodeoxynucleotides.: Vaccine. 2000 Jan 6;18(11-12):1081-7. Unique Identifier : AIDSLINE MED/20059989; Moss RB; Diveley J; Jensen F; Carlo DJ; The Immune Response Corporation, 5935 Darwin Court, Carlsbad, CA; 92008, USA. shotdoc@imnr.com; We examined the effect of a synthetic oligodeoxynucleotide containing unmethylated CpG immunostimulatory sequences (ISS) as an adjuvant for an HIV-1 immunogen (inactivated, gp120-depleted HIV-1 virus particles). The addition of the ISS to HIV-1 in incomplete Freund s adjuvant (IFA) was the optimal combination for the
Factors influencing cellular immune responses to feline immunodeficiency virus induced by DNA vaccination.: Vaccine. 2000 Jan 6;18(11-12):1118-32. Unique Identifier : AIDSLINE MED/20059994; Flynn JN; Hosie MJ; Rigby MA; Mackay N; Cannon CA; Dunsford T; Neil JC; Jarrett O; Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, Bearsden, Glasgow, UK.; n.flynn@vet.gla.ac.uk; Virus-specific effector cytotoxic T lymphocytes (CTL) were elicited in the peripheral blood of domestic cats following a single intramuscular inoculation of replication defective feline immunodeficiency virus proviral DNA (FIVDeltaRT). Higher levels of virus-specific cytolysis were observed in the blood when cats were
Formulation of HIV-envelope protein with lipid vesicles expressing ganglioside GM1 associated to cholera toxin B enhances mucosal immune responses.: Vaccine. 1999 Nov 12;18(7-8):604-11. Unique Identifier : AIDSLINE MED/20016510; Lian T; Bui T; Ho RJ; Department of Pharmaceutics, School of Pharmacy, University of; Washington, Box 357610, H272 Health Sciences Building, Seattle,; WA 98195-7610, USA.; Taking advantage of the ability of pentameric cholera toxin B subunit (CTB) to bind selectively to GM1, we developed recently a CTB-mediated GM1 lipid vesicle delivery system to target drugs and proteins to mucosal tissues [1]. In this report, we present the use of such a strategy to deliver an HIV envelope protein (H
Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: enhanced CD8+ T cell immunogenicity and protective efficacy in the influenza and malaria models.: Vaccine. 1999 Nov 12;18(7-8):623-32. Unique Identifier : AIDSLINE MED/20016513; Degano P; Schneider J; Hannan CM; Gilbert SC; Hill AV; PowderJect Pharmaceuticals plc, 4 Robert Robinson Avenue, The; Oxford Science Park, Oxford, UK. pilar.degano@ndm.ox.ac.uk; In influenza and malaria, CD8+ T cells play an important role in protective immunity in mice. An immunization strategy consisting of DNA priming followed by boosting with recombinant modified vaccinia virus Ankara (MVA) induces complete protection, associated with high levels of CD8+ T cells, against Plasmodium berghe
Cellular immune responses of pigs induced by vaccination with either a whole cell sonicate or pepsin-digested Brachyspira (Serpulina) hyodysenteriae bacterin.: Vaccine. 1999 Nov 12;18(7-8):711-9. Unique Identifier : AIDSLINE MED/20016523; Waters WR; Pesch BA; Hontecillas R; Sacco RE; Zuckermann FA; Wannemuehler MJ; Veterinary Medical Research Institute, Iowa State University,; 1802 Elwood Drive, Ames, IA 50011, USA. wwaters@iastate.edu; Brachyspira (Serpulina) hyodysenteriae infection of pigs (swine dysentery) causes a mucohemorrhagic diarrhea resulting in significant economic losses for producers. A commercial vaccine consisting of a proteinase-digested bacterin has shown efficacy in the reduction of disease due to B. hyodysenteriae. Vaccines consis
DNA vaccination as a tool to identify subdominant CD8 T cell epitopes.: Unique Identifier : AIDSLINE MED/20016524; Chen Y; Takimoto T; Liu L; Surman S; Woodland DL; DNA vaccination is highly efficient at inducing CD8(+) T cell responses in animal models. Here we investigated whether DNA vaccine technology could be exploited to identify subdominant cytotoxic T lymphocytes (CTL) epitopes. Previous studies have shown that the Sendai virus HN protein does not induce a CD8(+) T cell r
Genetic diversity of GBV-C/HGV strains among HIV infected-IVDU and blood donors from Buenos Aires, Argentina.: Virus Res. 1999 Dec 15;65(2):121-9. Unique Identifier : AIDSLINE MED/20050976; Oubina JR; Mathet V; Feld M; Della Latta MP; Ferrario D; Verdun R; Libonatti O; Fernandez J; Carballal G; Sanchez DO; Quarleri JF; Laboratorio de Hepatitis Virales, Departamento Microbiologia,; Facultad de Medicina, Universidad de Buenos Aires, (1121), Buenos; Aires, Argentina. j_oubina@hotmail.com; GBV-C/HGV RNA was investigated in serum samples from 70 HIV(+) intravenous drug users (IVDU), as well as from 200 blood donors from Buenos Aires, Argentina . Viral RNA was demonstrated in 21 IVDU by reverse transcription-nested PCR of the 5 UTR. c-DNA amplified products were ana
[Instructor in the army and fortifications guard--risk occupations for acute acoustic trauma and for wearing a hearing aid]: Soz Praventivmed. 1999;44(5):204-10. Unique Identifier : AIDSLINE MED/20055348; Rey B; Kunzli N; Probst R; Ackermann-Liebrich U; Bundesamt fur Militarversicherung, Bern.; In the Swiss army instructors and fortifications guards are exposed to firearms noise which harms the ear. It was investigated whether the decline in the cases of acute acoustic traumas in non-professional soldiers serving in the army from 1987 to 1996 also was detectable in army instructors and fortifications guards
Characteristics of heroin and cocaine users unknown to treatment agencies. Results from the Swiss Hidden Population Study.: Soz Praventivmed. 1999;44(5):222-32. Unique Identifier : AIDSLINE MED/20055350; Hausser D; Kubler D; Dubois-Arber F; Institut de recherche sur l'environnement construit, Swiss; Federal Institute of Technology Lausanne.; Dominique.Hausser@epfl.ch; The aim of this study was to compare the characteristics of heroin or cocaine users who are not in contact with drug-treatment agencies in Switzerland to the characteristics of a group who are in treatment. A sample of 917 users of heroin and/or cocaine was recruited outside t
Advances in HIV/AIDS therapy.: Adv Intern Med. 2000;45:1-40. Unique Identifier : AIDSLINE MED/20100961; Johnson SC; Gerber JG; Department of Medicine, University Hospital HIV/AIDS Clinical; Program, University of Colorado Health Sciences Center, Denver,; USA.; Advances in HIV/AIDS therapy have been rapid and profound. An improved understanding of HIV pathogenesis has demonstrated the need for aggressive antiretroviral therapy in most persons with HIV infection. Combinations of at least three drugs are necessary to fully suppress viral replication. Suppression of viral repli
Cytokine therapy of mycobacterial infections.: Adv Intern Med. 2000;45:431-52. Unique Identifier : AIDSLINE MED/20100975; Holland SM; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland, USA.; More than a century after the discovery of tuberculosis, mycobacterial infections are resurgent. The recent identification of mutations affecting the control of mycobacteria offer critical insights into the pathways necessary for the control of intracellular pathogens and bring us several steps closer to understanding
Advances in the recognition and treatment of endocrine complications in children with chronic illness.: Adv Pediatr. 1999;46:101-49. Unique Identifier : AIDSLINE MED/20110058; Zeitler PS; Travers S; Kappy MS; University of Colorado Health Sciences Center, Denver, USA.; Children with chronic illness live with the specific consequences of their illness, as well as secondary endocrine abnormalities that further compromise growth and pubertal development. These secondary abnormalities may significantly add to their physiologic and psychological burden. Although these endocrine abnormali
Diagnostic testing for HIV type 1 RNA in seronegative blood.: Am J Clin Pathol. 2000 Jan;113(1):128-34. Unique Identifier : AIDSLINE MED/20097484; Ritter D; Taylor J; Walkenbach R; Creer M; Arens MQ; Department of Pathology, St Louis University School of Medicine,; MO, USA.; We studied the feasibility of routine diagnostic testing for HIV-1 RNA at a publicly funded testing site. HIV-1 RNA was determined with a commercial polymerase chain reaction assay in pooled seronegative blood samples submitted for HIV testing to a public health laboratory. Recovery of HIV-1 RNA from the samples was e
The pathologic spectrum of gastrointestinal and hepatic histoplasmosis.: Am J Clin Pathol. 2000 Jan;113(1):64-72. Unique Identifier : AIDSLINE MED/20097477; Lamps LW; Molina CP; West AB; Haggitt RC; Scott MA; Department of Pathology, University of Arkansas for Medical; Sciences, Little Rock 72205, USA.; We characterized the pathologic spectrum of lesions in gastrointestinal and hepatic histoplasmosis by studying cases of disseminated disease in immunocompromised and immunocompetent patients from endemic and nonendemic areas. We evaluated 56 specimens from 52 patients with H&E and silver stains. Of these patients,
The ophthalmologist and the global impact of the AIDS epidemic LV Edward Jackson Memorial Lecture.: Am J Ophthalmol. 2000 Jan;129(1):1-8. Unique Identifier : AIDSLINE MED/20117130; Belfort R Jr; Federal University of Sao Paulo, Department of Ophthalmology,; Brazil. epmoftal@eu.ansp.br
Ocular lesions associated with HIV infection in India: a series of 100 consecutive patients evaluated at a referral center.: Unique Identifier : AIDSLINE MED/20117131; Biswas J; Madhavan HN; George AE; Kumarasamy N; Solomon S; PURPOSE: To document the ocular disorders seen in patients known to be infected with human immunodeficiency (HIV) virus at a referral eye clinic in India . METHODS: The first 100 individuals known to be HIV-positive at a referral eye clinic between 1993 and 1998 were enrolled in a pr
Continued risky behavior in HIV-infected youth.: Am J Public Health. 2000 Jan;90(1):115-8. Unique Identifier : AIDSLINE MED/20095612; Diamond C; Buskin S; University of Washington School of Public Health, Seattle, USA.; OBJECTIVES: The purpose of this study was to describe and compare risky behaviors in HIV-infected youths and adults. METHODS: Records of HIV-infected outpatients were reviewed for the period January 1990 to February 1998. Youths (younger than 22 years at HIV diagnosis and younger than 25 years at study entry, n = 139)
Sources of prenatal care data and their association with birth outcomes of HIV-infected women.: Am J Public Health. 2000 Jan;90(1):118-21. Unique Identifier : AIDSLINE MED/20095613; Turner BJ; Cocroft J; Newschaffer CJ; Hauck WW; Fanning TR; Berlin M; Center for Research in Medical Education and Health Care,; Jefferson Medical College of Thomas Jefferson University,; Philadelphia, Pa., USA. barbara.turner@mail.tju.edu; OBJECTIVES: Different sources of prenatal care data were used to examine the association between birth outcomes of HIV-infected women and the Adequacy of Prenatal Care Utilization (APNCU) index. METHODS: Adjusted odds ratios of birth outcomes for 1858 HIV-positive mothers were calculated for APNCU indexes on the basis
Outcomes of a randomized community-level HIV prevention intervention for women living in 18 low-income housing developments.: Am J Public Health. 2000 Jan;90(1):57-63. Unique Identifier : AIDSLINE MED/20095602; Sikkema KJ; Kelly JA; Winett RA; Solomon LJ; Cargill VA; Roffman RA; McAuliffe TL; Heckman TG; Anderson EA; Wagstaff DA; Norman AD; Perry MJ; Crumble DA; Mercer MB; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee, USA. kathleen.sikkema@yale.edu; OBJECTIVES: Women in impoverished inner-city neighborhoods are at high risk for contracting HIV. A randomized, multisite community-level HIV prevention trial was undertaken with women living in 18 low-income housing developments in 5 US cities. METHODS: Baseline and 12-month follow-up population risk characteristics w
Improved birth outcomes among HIV-infected women with enhanced Medicaid prenatal care.: Am J Public Health. 2000 Jan;90(1):85-91. Unique Identifier : AIDSLINE MED/20095606; Turner BJ; Newschaffer CJ; Cocroft J; Fanning TR; Marcus S; Hauck WW; Center for Research in Medical Education and Health Care,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pa., USA. barbara.turner@mail.tju.edu; OBJECTIVES: This study evaluated the impact of enhanced prenatal care on the birth outcomes of HIV-infected women. METHODS: Medicaid claims files linked to vital statistics were analyzed for 1723 HIV-infected women delivering a live-born singleton from January 1993 to October 1995. Prenatal care program visits were in
Emergency department management of blood and body fluid exposures [see comments]: Ann Emerg Med. 2000 Jan;35(1):47-62. Unique Identifier : AIDSLINE MED/20082742; Moran GJ; Department of Emergency Medicine and Division of Infectious; Diseases, UCLA School of Medicine, USA.; Exposure to blood and body fluids that may be contaminated with infectious agents is a common occupational hazard for health care workers. Health care workers in the emergency department or out-of-hospital setting are at especially high risk for exposure to blood or body fluids. Nonemergency health care workers are fr
Identification of a feline adenovirus isolate that replicates in monkey and human cells in vitro [letter]: Am J Vet Res. 1999 Dec;60(12):1463. Unique Identifier : AIDSLINE MED/20085864; Ongradi J
"Multi-enzyme-targeted" immunochemotherapy: a salvage therapy protocol.: INISTRATION & DOSAGE Anticancer Res. 1999 Jul-Aug;19(4C):3451-8. Unique Identifier : AIDSLINE MED/20095098; Klein HO; Demir G; University of Cologne, Germany. H-O.Klein@uni-koeln.de
Anti-HIV-1 activity of myo-inositol hexaphosphoric acid (IP6) and myo-inositol hexasulfate(IS6).: Anticancer Res. 1999 Sep-Oct;19(5A):3723-6. Unique Identifier : AIDSLINE MED/20091392; Otake T; Mori H; Morimoto M; Miyano K; Ueba N; Oishi I; Kunita N; Kurimura T; Osaka Prefectural Institute of Public Health, Japan.; otake@iph.pref.osaka.jp; It is known that polysulfates have some anti-HIV-1 activity. We investigated the anti-HIV-1 activity of myo-inositol hexaphosphoric acid (IP6) and myo-inositol hexasulfate(IS6), low molecular weight carbohydrates. IP6 and IS6 inhibited the replication of HIV-1 in a T cell line as well as that of a freshly isolated str
[Pulmonary aspergillosis as a terminal event in AIDS patient]: Arerugi. 1999 Oct;48(10):1180-3. Unique Identifier : AIDSLINE MED/20022056; Ando M; Hiraiwa M; Kawai M; Oki M; Saka H; Yamanaka K; Matsunaga S; Utsumi M; Ichihara S; Tuji T; Nishimura Y; Department of Respiratory Medicine, Nagoya National Hospital.
Tn5: A molecular window on transposition.: Biochem Biophys Res Commun. 1999 Dec 29;266(3):729-34. Unique Identifier : AIDSLINE MED/20072568; Reznikoff WS; Bhasin A; Davies DR; Goryshin IY; Mahnke LA; Naumann T; Rayment I; Steiniger-White M; Twining SS; Department of Biochemistry, University of Wisconsin, 433 Babcock; Drive, Madison, Wisconsin, 53706, USA. reznikoff@biochem.wisc.edu; DNA transposition is an underlying process involved in the remodeling of genomes in all types of organisms. We analyze the multiple steps in cut-and-paste transposition using the bacterial transposon Tn5 as a model. This system is particularly illuminating because of the existence of structural, genetic, and biochemic
Th2-type cytokines and the Fas way to pulmonary fibrosis: comment on the article by Atamas et al [letter]: Arthritis Rheum. 2000 Jan;43(1):236-8. Unique Identifier : AIDSLINE MED/20106517; Spinozzi F; Agea E; Russano A; Bistoni O; Bassotti G; deBenedictis FM; Bertotto A
A risk-benefit assessment of interleukin-2 as an adjunct to antiviral therapy in HIV infection.: Drug Saf. 2000 Jan;22(1):19-31. Unique Identifier : AIDSLINE MED/20112500; Piscitelli SC; Bhat N; Pau A; Clinical Center Pharmacy Department, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA. spisc@nih.gov; Immunomodulation has become a major focus of HIV research in an effort to augment, boost or restore the patient s damaged immune system. Recombinant interleukin-2 is currently being studied in phase II/III trials in HIV-infected patients. Several clinical studies have demonstrated that intermittent regimens are associ
Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy.: AIDS. 1999 Dec 24;13(18):F123-7. Unique Identifier : AIDSLINE MED/20094213; Devereux HL; Youle M; Johnson MA; Loveday C; Department of Retrovirology, Royal Free and University College; Medical School, London, UK.; OBJECTIVE: To investigate the rate of decline of drug resistant viruses after stopping therapy. DESIGN: Twenty-five patients receiving multiple combination therapies (mean five; range three to nine drugs) for more than 3 months were tested for HIV-1 resistance on therapy and off therapy. The sample off therapy was tes
Fat distribution and metabolic changes in patients with HIV infection [editorial]: AIDS. 1999 Dec 24;13(18):2493-505. Unique Identifier : AIDSLINE MED/20094214; Safrin S; Grunfeld C
Normal CD4 T-cell receptor repertoire in tonsillar tissue despite perturbed repertoire in peripheral blood in HIV-1 infected individuals.: AIDS. 1999 Dec 24;13(18):2507-13. Unique Identifier : AIDSLINE MED/20094215; Mugnaini EN; Syversen AM; Sannes M; Freng A; Brinchmann JE; Institute of Immunology, Rikshospitalet National Hospital, Oslo,; Norway.; OBJECTIVE: To compare the T-cell receptor (TCR) repertoire of T-cell subsets in peripheral blood and lymphoid tissue from HIV-1 infected individuals. DESIGN: Biopsies of tonsillar tissue and samples of peripheral blood were obtained from 10, mostly treatment-naive, HIV-1-infected individuals. CD4 and CD8 T-cell subset
The conserved carboxy terminal region of HIV-1 gp120 is recognized by seronegative HIV-exposed people.: AIDS. 1999 Dec 24;13(18):2515-21. Unique Identifier : AIDSLINE MED/20094216; Brown L; Souberbielle BE; Marriott JB; Westby M; Desselberger U; Kaye T; Gougeon ML; Dalgleish A; Oncology Department, St George's Hospital Medical School, London,; UK.; OBJECTIVE: To screen HIV-positive, long-term exposed seronegative and low-risk individuals for the presence of antibodies against regions of HIV-1 gp120 that share some degree of homology with HLA. METHODS: Sera were obtained from 63 HIV-1-infected subjects [52 Centers for Disease Control and Prevention (CDC) stage 2
Immunologic and virologic responses to HAART in severely immunocompromised HIV-1-infected children.: AIDS. 1999 Dec 24;13(18):2523-32. Unique Identifier : AIDSLINE MED/20094217; Essajee SM; Kim M; Gonzalez C; Rigaud M; Kaul A; Chandwani S; Hoover W; Lawrence R; Spiegel H; Pollack H; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical; Center/Bellevue Hospital, New York 10016, USA.; OBJECTIVE: To determine the long-term immunologic and virologic effects of highly active antiretroviral therapy (HAART) in children with AIDS. DESIGN: A prospective observational study. SETTING: Two pediatric HIV clinics. PARTICIPANTS: Twenty-five protease-inhibitor naive HIV-infected children (aged 2-18 years) with a
Quantitative pp65-antigenemia assay for the prediction of human cytomegalovirus disease in HIV-infected patients.: AIDS. 1999 Dec 24;13(18):2533-9. Unique Identifier : AIDSLINE MED/20094218; Blank BS; Meenhorst PL; Weverling GJ; Stout-Zonneveld AA; Pauw W; Mulder JW; van Dijk WC; Smits P; Lange JM; National AIDS Therapy Evaluation Center (NATEC), Department of; Internal Medicine, Amsterdam, The Netherlands.; s.n.blank@amc.uva.nl; OBJECTIVE: To evaluate the ability of a quantified pp65-antigenemia assay to predict the development of human cytomegalovirus (HCMV) disease in patients with an advanced HIV infection. DESIGN: A prospective longitudinal study between March 1993 and December 1996. Blood samples for
Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype.: AIDS. 1999 Dec 24;13(18):2541-6. Unique Identifier : AIDSLINE MED/20094219; Verhofstede C; Wanzeele FV; Van Der Gucht B; De Cabooter N; Plum J; AIDS Reference Laboratory, University Hospital, Gent, Belgium.; chris.verhofstede@rug.ac.be; OBJECTIVES: To study the effect of the interruption of reverse transriptase inhibitor (RTI) therapy or a switch from RTI to protease inhibitors , on the genotypic drug-resistance pattern of plasma HIV-1. METHODS: Nine patients who completely stopped all medication, a
Uniform risk of clinical progression despite differences in utilization of highly active antiretroviral therapy: Swiss HIV Cohort Study.: AIDS. 1999 Dec 24;13(18):2547-54. Unique Identifier : AIDSLINE MED/20094220; Junghans C; Low N; Chan P; Witschi A; Vernazza P; Egger M; Department of Social Medicine, University of Bristol, UK.; OBJECTIVE: To compare the initiation of highly active antiretroviral therapy (HAART) in HIV-infected patients according to sex, route of HIV acquisition and education, and to assess the impact of differences in utilization on the probability of progression to AIDS. DESIGN AND SETTING: Swiss HIV Cohort Study, a nationa
The prognostic value of the World Health Organisation staging system for HIV infection and disease in rural Uganda.: AIDS. 1999 Dec 24;13(18):2555-62. Unique Identifier : AIDSLINE MED/20094221; Malamba SS; Morgan D; Clayton T; Mayanja B; Okongo M; Whitworth J; Medical Research Council Programme on AIDS/Uganda Virus Research; Institute, Entebbe.; OBJECTIVE: To assess whether the WHO staging classification for HIV provides prognostically valuable and applicable information in rural Uganda . PATIENTS AND STUDY DESIGN: Data were obtained from a population-based cohort of 232 HIV-infected individuals. METHODS: Clinical informati
AIDS-related cancers in Africa: maturation of the epidemic in Uganda [see comments]: AIDS. 1999 Dec 24;13(18):2563-70. Unique Identifier : AIDSLINE MED/20094222; Parkin DM; Wabinga H; Nambooze S; Wabwire-Mangen F; Unit of Descriptive Epidemiology, International Agency for; Research on Cancer, Lyon, France. parkin@iarc.fr; BACKGROUND: The AIDS epidemic has passed its peak in Uganda , with possible consequences for the risk of cancers related to infectious agents. OBJECTIVE: To compare the incidence of cancers possibly linked to infections with HIV, before the AIDS epidemic (the 1960s), at its high poi
Long term global evaluation of a national AIDS prevention strategy: the case of Switzerland.: Unique Identifier : AIDSLINE MED/20094223; Dubois-Arber F; Jeannin A; Spencer B; OBJECTIVES: The Swiss Aids prevention strategy has been subject to a continuous process of evaluation for the past 12 years. This paper describes the conceptual approach, methodology, results obtained and contribution to policy-making of that evaluation. DESIGN: The evaluation is on-going, global with respect to all c
Aids and cancer in Africa: the evolving epidemic in Zimbabwe [see comments]: AIDS. 1999 Dec 24;13(18):2583-8. Unique Identifier : AIDSLINE MED/20094224; Chokunonga E; Levy LM; Bassett MT; Borok MZ; Mauchaza BG; Chirenje MZ; Parkin DM; Zimbabwe Cancer Registry, Parirenyatwa Hospital, Harare.; BACKGROUND: Zimbabwe is severely affected by the AIDS epidemic, and many cancers in African populations are related to infectious agents. OBJECTIVE: To study the current pattern, and short-term changes in incidence, of cancers related to infectious agents (and especially to HIV),
The spectrum of Aids-associated cancers in Africa [editorial; comment]: AIDS. 1999 Dec 24;13(18):2589-90. Unique Identifier : AIDSLINE MED/20094225; Serraino D
Use and cost of hospital services by HIV-infected children during the era of antiretroviral monotherapy [letter]: AIDS. 1999 Dec 24;13(18):2591-3. Unique Identifier : AIDSLINE MED/20094226; Mandalia S; Beck EJ; Beecham J; Griffith R; Walters S; Boulton M; Miller D
Hepatitis C in an urban population infected with the human immunodeficiency virus [letter]: AIDS. 1999 Dec 24;13(18):2593-5. Unique Identifier : AIDSLINE MED/20094227; Weinstock DM; Merrick S; Malak SA; Jacobs J; Sepkowitz KA
The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir but not indinavir impair the epithelial barrier in the human intestinal cell line HT-29/B6 [letter]: AIDS. 1999 Dec 24;13(18):2595-7. Unique Identifier : AIDSLINE MED/20094228; Bode H; Schmidt W; Schulzke JD; Fromm M; Zippel T; Wahnschaffe U; Bendfeldt K; Riecken EO; Ullrich R
HLA-A*1101-restricted cytotoxic T lymphocyte recognition for a novel epitope derived from the HIV-1 Env protein [letter]: AIDS. 1999 Dec 24;13(18):2597-9. Unique Identifier : AIDSLINE MED/20094229; Fukada K; Tomiyama H; Chujoh Y; Miwa K; Kaneko Y; Oka S; Takiguchi M
Secretory leukocyte protease inhibitor in colostrum and breast milk is not a major determinant of the protection of early postnatal transmission of HIV [letter]: AIDS. 1999 Dec 24;13(18):2599-602. Unique Identifier : AIDSLINE MED/20094230; Becquart P; Gresenguet G; Hocini H; Kazatchkine MD; Belec L
Reply to Davis and colleagues: Twice weekly, directly observed treatment for HIV-infected and uninfected tuberculosis patients: cohort study in rural South Africa [letter]: AIDS. 1999 Dec 24;13(18):2601-2. Unique Identifier : AIDSLINE MED/20124926; Barker J; Makatini Z; Millard J
Distribution of HIV-1 disease modifying regulated on activation normal T cell expressed and secreted haplotypes in Asian, African and Caucasian individuals. French ALT and IMMUNOCO Study Group [letter]: AIDS. 1999 Dec 24;13(18):2602-3. Unique Identifier : AIDSLINE MED/20094231; Liu H; Shioda T; Nagai Y; Iwamoto A; Wasi C; Ma J; Liang W; Takebe Y; Theodorou I; Magierowska M; Krishnamoorty R; Chaventre A; Debre P
AIDS-related body cavity-based lymphomas, herpesvirus-8 and HIV infection: a study of seven cases [letter]: AIDS. 1999 Dec 24;13(18):2603-5. Unique Identifier : AIDSLINE MED/20094232; Valencia ME; Martinez P; Moreno V; Laguna F; Lahoz JG
Symptomatic osteoporosis in two young HIV-positive African women [letter]: AIDS. 1999 Dec 24;13(18):2605-6. Unique Identifier : AIDSLINE MED/20094233; Stephens EA; Das R; Madge S; Barter J; Johnson MA
Complete reversibility of severe nucleoside-induced lipodystrophy [letter]: AIDS. 1999 Dec 24;13(18):2606-7. Unique Identifier : AIDSLINE MED/20094234; Strobel M; Muller P; Claudel P
Modelling the cost effectiveness of preventing perinatal HIV transmission: comprehensiveness and comparability [letter]: AIDS. 1999 Dec 24;13(18):2607-9. Unique Identifier : AIDSLINE MED/20094235; Pinkerton SD
[Methodological problems in the evaluation of cognitive disorders associated with HIV]: Neurologia. 1999 Nov;14(9):452-8. Unique Identifier : AIDSLINE MED/20079843; Pereda M; Gomez del Barrio A; Ayuso Mateos JL; Servicio de Psiquiatria, Hospital Universitario Marques de; Valdecilla, Universidad de Cantabria.
The role of human herpesvirus 8 in the pathogenesis of Kaposi's sarcoma.: Adv Dermatol. 1999;14:167-206; discussion 207. Unique Identifier : AIDSLINE MED/20108111; Blauvelt A; National Institutes of Health, Bethesda, Maryland, USA.; Human herpesvirus 8 is a novel gamma-herpesvirus that has been linked with all clinical types of KS through both DNA and serologic studies. By electron microscopic, in situ hybridization, and in situ PCR studies, virus is found in tumor spindle cells, in normal-appearing endothelial cells within lesions, and in tumor-
Epidermal Langerhans cells: from neurons to nature's adjuvants.: Adv Dermatol. 1999;14:209-58; discussion 259. Unique Identifier : AIDSLINE MED/20108112; Jakob T; Udey MC; Dermatology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; Once obscure cells of interest to only a few dermatologists, LCs have become perhaps the best studied of all the nonlymphoid DCs. Seminal studies carried out by Steinman and co-workers over a number of years have demonstrated that interdigitating DCs are required for the priming of naive T cells in vivo and that LCs (
[Splenectomy in immune thrombocytopenia and other hematological diseases]: G Chir. 1999 Nov-Dec;20(11-12):479-86. Unique Identifier : AIDSLINE MED/20109414; Lanzi S; Lancini GP; Piardi T; Biasca F; Ottaviani GM; Rossi G; Pizzoccaro C; Pouche A; Cattedra di Semeiotica Chirurgica, Universita degli Studi di; Brescia.; The Authors report a retrospective study of 74 splenectomies performed for hematologic diseases. The role of splenectomy has changed over recent years with increased indications for immune thrombocytopenic purpura (ITP). The aim of this study was to assess indications to surgery in relation to clinical presentation wi
Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases.: Br J Cancer. 2000 Jan;82(2):399-403. Unique Identifier : AIDSLINE MED/20110815; Breitkreutz R; Babylon A; Hack V; Schuster K; Tokus M; Bohles H; Hagmuller E; Edler L; Holm E; Droge W; Deutsches Krebsforschungszentrum, Division of Immunochemistry,; Heidelberg, Germany.; Abnormally low intramuscular glutamate and glutathione (GSH) levels and/or a decreased muscular uptake of glutamate by the skeletal muscle tissue have previously been found in malignant diseases and simian immunodeficiency virus (SIV) infection and may contribute to the development of cachexia. We tested the hypothesi
Osteitis fibrosa cystica generalizata with adult T-cell leukaemia: a case report.: Br J Haematol. 1999 Dec;107(4):892-4. Unique Identifier : AIDSLINE MED/20074651; Yamaguchi T; Hirano T; Kumagai K; Tsurumoto T; Shindo H; Majima R; Arima N; Department of Orthopaedic Surgery, Nagasaki University School of; Medicine, Nagasaki, Japan. tetsuo1@pastel.ocn.ne.jp; We report on a 62-year-old female initially suffering from extreme pain in both her lower extremities. Plain radiographs revealed multiple osteolytic lesions. Laboratory analyses indicated high levels of serum calcium and parathyroid hormone related protein (PTHrP) and detected HTLV-1 antibody. Histological examinatio
Ethics and HIV treatments: Al Gore under fire [news]: Ann Oncol. 1999 Nov;10(11):1261-2. Unique Identifier : AIDSLINE MED/20097026; Antonini R
Neoplastic complications of HIV infection.: Ann Oncol. 1999 Nov;10(11):1271-86. Unique Identifier : AIDSLINE MED/20097028; Spina M; Vaccher E; Carbone A; Tirelli U; Division of Medical Oncology A, Istituto Nazionale Tumori,; Aviano, Italy.
Cytomegalovirus colitis after administration of docetaxel-5-fluorouracil-cisplatin chemotherapy for locally advanced hypopharyngeal cancer.: Ann Oncol. 1999 Nov;10(11):1369-72. Unique Identifier : AIDSLINE MED/20097042; Van den Brande J; Schrijvers D; Colpaert C; Vermorken JB; Department of Medical Oncology, University Hospital Antwerp; (UZA), Edegem, Belgium. JanVdBra@mail.dma.be; We present the case of a patient with a locally advanced hypopharyngeal carcinoma who developed a severe cytomegalovirus ( CMV ) colitis after his first chemotherapy course with 5-fluorouracil (5-FU), docetaxel and cisplatin. T
Mutation of BAX occurs infrequently in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas.: Genes Chromosomes Cancer. 2000 Feb;27(2):177-82. Unique Identifier : AIDSLINE MED/20080733; Gaidano G; Vivenza D; Forconi F; Capello D; Gloghini A; Bhatia K; Gutierrez M; Gallicchio M; Avanzi GC; Fassone L; Ariatti C; Buonaiuto D; Cingolani A; Saglio G; Tirelli U; Larocca LM; Dalla-Favera R; Carbone A; Division of Internal Medicine, Department of Medical Sciences,; Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.; gaidano@med.no.unipmn.it; Acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin s lymphomas (AIDS-NHLs) consistently derive from B cells, are histologically heterogeneous, and are associated with distinct molecular pathways depending upon histology. Recently, it has been proposed that inactivating mutations of the bax death agonist may
[Visceral leishmaniasis: a comparative study of patients with and without human immunodeficiency virus infection]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):515-20. Unique Identifier : AIDSLINE MED/20116428; Reus S; Sanchez R; Portilla J; Boix V; Priego M; Merino E; Roman F; Unidad de Enfermedades Infecciosas, Hospital General; Universitario de Alicante.; BACKGROUND: The changes that HIV coinfection can induce in clinical symptoms, response to treatment and prognosis of visceral Leishmaniasis (VL) are not well known. METHOD: We retrospectively describe the characteristics of VL in patients with and without HIV infection, between 1988-1998. RESULTS: Fifty episodes of VL
[Multiple hemorrhagic cerebral toxoplasmosis and AIDS (letter)]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):531-2. Unique Identifier : AIDSLINE MED/20116432; Correa-Nazco VJ; Miguelez M; Laynez P; Linares M
[Bacteremic pneumonia due to Rhodococcus equi in a patient with human immunodeficiency virus infection and visceral leishmaniasis (letter)]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):532-3. Unique Identifier : AIDSLINE MED/20116433; Sanchez JF; Ojeda I; Martin C; Sanchez F; Vinuelas J
[Gabapentin in the treatment of polyneuropathy associated with the human immunodeficiency virus (letter)]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):534-5. Unique Identifier : AIDSLINE MED/20116435; Pena D; Prada JL; de La Torre J; del Arco A; Garcia-Alegria J
[Necrotizing pneumonia due to Salmonella sp. complicated by pneumothorax in a patient infected with the human immunodeficiency virus (letter)]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):536-8. Unique Identifier : AIDSLINE MED/20116438; Pintado V; Navas E; Moreno L; Moreno ME
[A necrotic ulcer due to Fusarium sp. in a neutropenic patient (letter)]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):539. Unique Identifier : AIDSLINE MED/20116440; Teira R; Rolston KV
[What is the risk of human immunodeficiency virus infection in health personnel? What are the criteria for postexposure prophylaxis?]: Enferm Infecc Microbiol Clin. 1999 Dec;17(10):541-4. Unique Identifier : AIDSLINE MED/20116441; Farinas MC; Farinas-Alvarez C; Departamento de Medicina Interna, Hospital Universitario Marques; de Valdecilla, Santander. mirfac@humv.es
Education of the trauma team: video evaluation of the compliance with universal barrier precautions in resuscitation.: Eur J Surg. 1999 Dec;165(12):1125-8. Unique Identifier : AIDSLINE MED/20100498; Brooks AJ; Phipson M; Potgieter A; Koertzen H; Boffard KD; Department of Surgery, University of the Witwatersrand,; Johannesburg, South Africa.; OBJECTIVE: To assess the effectiveness of an educational symposium designed to improve compliance with universal barrier precautions by the use of video analysis of resuscitations. DESIGN: Prospective single blind analysis of data. SETTING: Hospital Trauma Unit, Johannesburg, South Af
[Treatment of visceral leishmaniasis in patients with antimonials: is there a maximal dose? (letter)]: An Med Interna. 1999 Nov;16(11):602. Unique Identifier : AIDSLINE MED/20103362; Llorens Soriano P; Vicente Ull R; Paricio Blasco A; Cervera Juan A; Rubio Rodrigo MJ
Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes.: Eur Cytokine Netw. 1999 Dec;10(4):501-8. Unique Identifier : AIDSLINE MED/20053987; Foussat A; Wijdenes J; Bouchet L; Gaidano G; Neipel F; Balabanian K; Galanaud P; Couderc J; Emilie D; INSERM U. 131, Institut Paris-Sud sur les Cytokines, 32, rue des; Carnets, 92140 Clamart, France.; Human interleukin-6 (hIL-6) acts as a growth factor in several human B lymphoid cancers. As human herpesvirus-8 (HHV-8) encodes for a viral IL-6 (vIL-6), the viral cytokine may be responsible for several manifestations of HHV-8-related disorders. Using an anti-hIL-6 mAb (B-E8) which does not recognize vIL-6, we invest
Effects of immunosuppressive therapy on murine Leishmania infantum visceral leishmaniosis.: Eur Cytokine Netw. 1999 Dec;10(4):557-9. Unique Identifier : AIDSLINE MED/20053994; Gangneux JP; Chau F; Sulahian A; Derouin F; Garin YJ; Laboratoire de Parasitologie-Mycologie, Faculte de Medecine; Lariboisiere-Saint-Louis, 15, rue de l'Ecole-de-Medecine, 75270; Paris Cedex 06, France.; We evaluated the effect of immunosuppressive therapy on the course of infection, the spleen cell immunophenotype and cytokine production during murine Leishmania infantum visceral leishmaniosis (VL). Rousseau et al. [1] recently reported that prolonged administration of dexamethasone induces limited reactivation of ch
Pharmacokinetic interactions between HIV-protease inhibitors in rats.: Biopharm Drug Dispos. 1999 Jul;20(5):241-7. Unique Identifier : AIDSLINE MED/20062384; Yamaji H; Matsumura Y; Yoshikawa Y; Takada K; Department of Pharmacokinetics, Kyoto Pharmaceutical University,; Yamashina-ku, Kyoto 607-8414, Japan.; The interactions of four HIV- protease inhibitors , ritonavir (RIT), saquinavir (SAQ), indinavir (IND) and nelfinavir (NEL), were ex
Stable recombinant expression of the anti HIV-1 monoclonal antibody 2F5 after IgG3/IgG1 subclass switch in CHO cells.: Biotechnol Bioeng. 2000 Jan 5;67(1):97-103. Unique Identifier : AIDSLINE MED/20050117; Kunert R; Steinfellner W; Purtscher M; Assadian A; Katinger H; Institute of Applied Microbiology, University of Agricultural; Sciences, Muthgasse 18, Haus B, A-1190 Vienna, Austria.; R.Kunert@iam.boku.ac.at; The human monoclonal antibody (humAb) 2F5 is a potent candidate for immunotherapy of HIV-1. The xenohybridoma derived humAb 2F5 is of IgG3 kappa isotype. Generally, IgG1 isotype has a longer half-life (beta-clearance) in humans than IgG3. Therefore the isotype was switched to an IgG1 by ligation of the 2F5 heavy chain
Characteristics of human T-lymphotropic virus type-1 (HTLV-1)-infected cell line MT-2, which is not killed by a natural killer cell line NK-92 but is killed by lymphokine-activated killer cells.: Oncol Res. 1999;11(5):213-8. Unique Identifier : AIDSLINE MED/20074327; Komatsu F; Yoshida S; Blood Transfusion Service, School of Medicine, Tokyo Medical and; Dental University, Japan.; Natural killer (NK) cell-mediated cytolysis (NK-lysis) is triggered by costimulatory signals of adhesion molecules and is downregulated by negative signals of killer cell inhibitory receptors (KIRs). Recently, a NK cell line, NK-92, was established. This cell line can kill several tumor cells, which possess adhesion m
Feedback mechanisms between T helper cells and macrophages in the determination of the immune response.: Math Biosci. 2000 Jan;163(1):35-58. Unique Identifier : AIDSLINE MED/20118437; Bar-Or RL; Department of Applied Mathematics and Computer Science, Weizmann; Institute of Science, Rehovot, Israel.; ruthy@wisorg.weizmann.ac.il; The interactions between macrophages and T helper (Th) cells are a complex interplay of positive and negative signals. Some of the mathematical models of interactions between T helpers have indeed taken the influence of macrophages into account. In this work the macrophage is not considered as an extrinsic agent, that
Bad blood? Survey of public's views on unlinked anonymous testing of blood for HIV and other diseases.: BMJ. 2000 Jan 8;320(7227):90-1. Unique Identifier : AIDSLINE MED/20090727; Kessel A; Watts C; Weiss HA; Epidemiology Unit, London School of Hygiene and Tropical; Medicine, London WC1E 7HT. anthony.kessel@lshtm.ac.uk
Prevalence of antibody to human T cell leukaemia/lymphoma virus in women attending antenatal clinic in southeast London: retrospective study.: BMJ. 2000 Jan 8;320(7227):92-3. Unique Identifier : AIDSLINE MED/20090728; Donati M; Seyedzadeh H; Leung T; Blott M; Zuckerman M; Public Health Laboratory and Medical Microbiology, Department of; Virology, Guy's, King's and St Thomas's School of Medicine,; King's College Hospital (Dulwich), London SE22 8QF.
Co-infection with malaria and HIV in injecting drug users in Brazil: a new challenge to public health?: Addiction. 1999 Aug;94(8):1165-74. Unique Identifier : AIDSLINE MED/20082593; Bastos FI; Barcellos C; Lowndes CM; Friedman SR; Department of Health Information (DID/CICT), Oswaldo Cruz; Foundation (FIOCRUZ), UNAIDS Collaborating Centre, Rio de; Janeiro, Brazil. Bastos@Fiocruz.br; AIMS: To describe AIDS and malaria geography in Brazil , highlighting the role of injecting drug users (IDUs) in malaria outbreaks occurring in malaria-free regions, and the potential clinical and public health implications of malaria/HIV co-infection. DESIGN: Review of the availabl
Drink, illicit drugs and unsafe sex in women.: Addiction. 1999 Aug;94(8):1209-18. Unique Identifier : AIDSLINE MED/20082598; Taylor J; Fulop N; Green J; Department of Clinical Health Psychology, St Mary's Hospital,; London, UK.; AIMS: To establish the extent and nature of linkages between illicit drug and alcohol use and sexual behaviour in women. PARTICIPANTS AND SETTING: One hundred women attending either a Genitourinary Medicine Clinic or a Family Planning Clinic. DESIGN: Respondents were interviewed using a semi-structured interview sched
HIV infection associated with drug injecting in the newly independent states, eastern Europe: the social and economic context of epidemics.: Addiction. 1999 Sep;94(9):1323-36. Unique Identifier : AIDSLINE MED/20082580; Rhodes T; Ball A; Stimson GV; Kobyshcha Y; Fitch C; Pokrovsky V; Bezruchenko-Novachuk M; Burrows D; Renton A; Andrushchak L; Department of Social Science and Medicine, Imperial College; School of Medicine, University of London, UK. t.rhodes@ic.ac.uk; AIMS: We review recent trends in HIV associated with injecting drug use (IDU) in the Newly Independent States (NIS) in eastern Europe, including Belarus , Moldova ,
Monitoring human cytomegalovirus viral load in peripheral blood leukocytes of renal transplant recipients by a simple limiting dilution-PCR assay.: Braz J Med Biol Res. 1999 Dec;32(12):1515-23. Unique Identifier : AIDSLINE MED/20054117; Caballero OL; Costa MC; Trevisan A; Oliveira RM; Viotti EA; Tavora ER; Vilaca SS; Sabagga E; De-Paula FJ; Tavora PF; Brasileiro-Filho G; Villa LL; Simpson AJ; Laboratorios de Virologia, Instituto Ludwig de Pesquisa sobre o; Cancer, Sao Paulo, SP, Brasil.; To assess the clinical relevance of a semi-quantitative measurement of human cytomegalovirus (HCMV) DNA in renal transplant recipients within the typical clinical context of a developing country where virtually 100% of both receptors and donors are seropositive for this virus, we h
Efficient lentiviral transduction of liver requires cell cycling in vivo.: Nat Genet. 2000 Jan;24(1):49-52. Unique Identifier : AIDSLINE MED/20082807; Park F; Ohashi K; Chiu W; Naldini L; Kay MA; Department of Pediatrics, Stanford University, Stanford,; California, USA.; Human-immunodeficiency-virus (HIV)-based lentiviral vectors are a promising tool for in vivo gene therapy. Unlike Moloney-murine-leukaemia-based retroviruses (MLV), lentiviruses are believed to stably transduce quiescent (non-cycling) cells in various organs. No previous studies, however, have directly established the
Learning from lentiviruses [news]: Nat Genet. 2000 Jan;24(1):8-9. Unique Identifier : AIDSLINE MED/20082796; Emerman M; The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell activation may influence
Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120.: Eur J Neurosci. 1999 Dec;11(12):4398-402. Unique Identifier : AIDSLINE MED/20062508; D'hooge R; Franck F; Mucke L; De Deyn PP; Laboratory of Neurochemistry and Behaviour, Born-Bunge; Foundation, University of Antwerp, Belgium.; Transgenic mice expressing HIV-1 coat glycoprotein gp120 in brain glial cells were previously shown to display AIDS dementia-like neuropathological changes and reduced hippocampal long-term potentiation. In this report, neuromotor and cognitive performance in 3- and 12-month-old gp120-expressing mice was compared with
Identification of the Nef-associated kinase as p21-activated kinase 2.: Curr Biol. 1999 Dec 2;9(23):1407-10. Unique Identifier : AIDSLINE MED/20076864; Renkema GH; Manninen A; Mann DA; Harris M; Saksela K; Institute of Medical Technology, University of Tampere, Tampere,; Finland.; The Nef protein of primate immunodeficiency viruses plays an important role in the pathogenesis of acquired immunodeficiency syndrome (AIDS) [1] [2]. The interaction of Nef with the Nef-associated kinase (NAK) is one of the most conserved properties of different human and simian immunodeficiency virus (HIV and SIV) Ne
Use of needles and syringes in Miami and Valencia: observations of high and low availability.: Med Anthropol Q. 1999 Dec;13(4):413-35. Unique Identifier : AIDSLINE MED/20091719; Page JB; Salazar Fraile J; University of Miami Research, Department of Psychiatry, (M839),; FL 33136, USA.; Two studies engaged in gathering data on injecting drug users (IDUs) employed supplementary resources to enhance their ethnographic components and compare patterns of use of needles/syringes (n/s) in two geographically similar but culturally distinct cities. Despite its policy of making n/s highly available at fair pr
Sex and the genetic diversity of HIV-1 [news; comment]: Nat Med. 2000 Jan;6(1):23-5. Unique Identifier : AIDSLINE MED/20081016; Ray SC; Quinn TC
China's first international HIV vaccine meeting: the war of the roses [news]: Nat Med. 2000 Jan;6(1):5. Unique Identifier : AIDSLINE MED/20132055; Watanabe M
Gender differences in HIV-1 diversity at time of infection [see comments]: Nat Med. 2000 Jan;6(1):71-5. Unique Identifier : AIDSLINE MED/20081026; Long EM; Martin HL Jr; Kreiss JK; Rainwater SM; Lavreys L; Jackson DJ; Rakwar J; Mandaliya K; Overbaugh J; Division of Human Biology, Fred Hutchinson Cancer Research; Center, Seattle, Washington, USA.; To develop an HIV-1 vaccine with global efficacy, it is important to identify and characterize the viruses that are transmitted, particularly to individuals living in areas of high incidence. Several studies have shown that virus from the blood of acutely infected adults was homogeneous, even when the virus population
Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy.: Nat Med. 2000 Jan;6(1):76-81. Unique Identifier : AIDSLINE MED/20081027; Sharkey ME; Teo I; Greenough T; Sharova N; Luzuriaga K; Sullivan JL; Bucy RP; Kostrikis LG; Haase A; Veryard C; Davaro RE; Cheeseman SH; Daly JS; Bova C; Ellison RT 3rd; Mady B; Lai KK; Moyle G; Nelson M; Gazzard B; Shaunak S; Stevenson M; University of Massachusetts Medical School, Program in Molecular; Medicine, 373 Plantation Street, Suite 319, Worcester,; Massachusetts 01605, USA.; Treatment of HIV-1-infected individuals with a combination of anti-retroviral agents results in sustained suppression of HIV-1 replication, as evidenced by a reduction in plasma viral RNA to levels below the limit of detection of available assays. However, even in patients whose plasma viral RNA levels have been suppr
The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy.: Nat Med. 2000 Jan;6(1):82-5. Unique Identifier : AIDSLINE MED/20081028; Ramratnam B; Mittler JE; Zhang L; Boden D; Hurley A; Fang F; Macken CA; Perelson AS; Markowitz M; Ho DD; Aaron Diamond AIDS Research Center, The Rockefeller University,; 455 First Avenue, New York, New York 10016, USA.; Replication-competent HIV-1 can be isolated from infected patients despite prolonged plasma virus suppression by anti-retroviral treatment. Recent studies have identified resting, memory CD4+ T lymphocytes as a long-lived latent reservoir of HIV-1 (refs. 4,5). Cross-sectional analyses indicate that the reservoir is ra
[Control of tuberculosis in relation to the HIV/AIDS epidemic. Work Group at the Secretariat of the National Plan on AIDS]: Rev Esp Salud Publica. 1999 Sep-Oct;73(5):533-47. Unique Identifier : AIDSLINE MED/20116525; On April 7, 1999, the Monographic Meeting on HIV Infection and Tuberculosis was held at the Secretariat of the National AIDS Plan for the purpose of setting out certain clinical and health care policy recommendations concerning the control of tuberculosis (TB) with regard to the HIV infection epidemic, those in attend
[Survival of patients with HIV-related tuberculosis. Study of mortality during the first 9 months of treatment]: Rev Esp Salud Publica. 1999 Sep-Oct;73(5):549-62. Unique Identifier : AIDSLINE MED/20116526; Falques Casanovas M; Langohr K; Gomez Melis G; Garcia de Olalla Rizo P; Jansa Lopez del Vallado JM; Cayla Buqueras JA; Departament d'Estadistica, Universitat Politecnica de; Catalunya, Barcelona.; BACKGROUND: Among the individuals with tuberculosis who are infected with HIV a high degree of lethality has been found to exist during the first few weeks following the start of tuberculosis treatment. In this study, the survival of these individuals is studied within the framework of a retrospective cohort study. ME
Therapy of special HIV-associated diseases: HCV-HIV-co-infection and AIDS-related Kaposi's sarcoma - official satellite to the 7th European Conference on Clinical Aspects and Treatment of HIV-infection, October 23, 1999 in Lisbon, Portugal.: Eur J Med Res. 1999 Dec 16;4(12):507-13. Unique Identifier : AIDSLINE MED/20079345; Goebel FD; Jablonowski H; Medizinische Poliklinik der Universitat Munchen,; Pettenkoferstr. 8a, D-80336 Munchen, Germany.; goebel@pk-i.med-uni-muenchen.de; BACKGROUND: In the era of highly active antiretroviral therapy (HAART), certain complications of HIV-disease as e.g. opportunistic infections and Kaposi s sarcoma (KS) have significantly diminished. New insights in pathological pathways revealed the role of co-viruses as HHV-8 and HCV so that in our days AIDS-associat
Influence of foscarnet on HIV-associated Kaposi's sarcoma derived cell lines.: Eur J Med Res. 1999 Dec 16;4(12):514-6. Unique Identifier : AIDSLINE MED/20079346; Willers CP; Reimann G; Mertins L; Brockmeyer NH; Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56,; D-44791 Bochum, Germany.; Recent reports showed a positive therapeutic effect of foscarnet on Kaposi s sarcoma (KS) in HIV-positive patients. We investigated the therapeutic effect of foscarnet on KS-derived cell lines. Three KS spindle cell cultures of HIV-positive patients as well three fibroblast cell cultures of HIV-positive as HIV-negativ
Cytomegalovirus retinitis in AIDS patients: 1999 update [editorial]: Ocul Immunol Inflamm. 1999 Dec;7(3-4):123-8. Unique Identifier : AIDSLINE MED/20132058; Herbort CP; LeHoang P
HIV epidemiology and treatment - 1999.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):129-32. Unique Identifier : AIDSLINE MED/20079367; Telenti A; Bally F; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; amalio.telenti@chuv.hospvd.ch; Potent antiretroviral treatment has led to a dramatic decrease in HIV-associated morbidity and mortality. This paper reviews (1) current recommendations for the initiation of antiretroviral therapy, (2) the natural history of HIV infection after initiation of treatment, and (3) toxicity and resistance issues.
Cytomegalovirus: virological facts for clinicians.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):133-7. Unique Identifier : AIDSLINE MED/20079368; Bodaghi B; Michelson S; Department of Ophthalmology, H^opital Piti:e-Salp^etri`ere,; Paris, France. bodaghi@pasteur.fr; Human cytomegalovirus (HCMV) is a complex DNA virus encoding more than 200 viral proteins. This highly adapted opportunist agent has developed several ways to evade the immune system. Among all clinical features due to HCMV, retinitis occurs especially in severely immunosuppressed
Detection of CMV DNA in peripheral blood leukocytes as a long-range harbinger of CMV disease in HIV-infected patients. Swiss HIV Cohort Study.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):147-57. Unique Identifier : AIDSLINE MED/20079370; Jaton KR; Muheim CR; Barbani MT; Sahli RR; Rudaz PR; Meylan PR; CHUV, Institute of Microbiology, Lausanne, Switzerland.; The incidence of cytomegalovirus ( CMV ) end-organ disease can be reduced in AIDS patients by oral ganciclovir. However, the cost effectiveness of this prophylaxis is low. Targeting prophylaxis to patients with the highest risk
Epidemiological considerations about retinal opportunistic infections in HIV-infected patients in France.: Unique Identifier : AIDSLINE MED/20079372 P
The epidemiology of CMV retinitis in Africa.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):173-7. Unique Identifier : AIDSLINE MED/20079373; Kestelyn P; Department of Ophthalmology, University Hospital, Gent, Belgium.; AIM: To analyze the prevalence of cytomegalovirus ( CMV ) retinitis in African AIDS patients. METHOD: A Medline survey was carried out to identify reports on the ocular manifestations of HIV infection in African patients. Relev
New strategies for the management of AIDS-related CMV retinitis in the era of potent antiretroviral therapy.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):179-88. Unique Identifier : AIDSLINE MED/20079374; Holland GN; Jules Stein Eye Institute, Department of Ophthalmology, UCLA; Ocular Inflammatory Disease Center, UCLA School of Medicine, Los; Angeles, CA 90095-7003, USA.; The management of AIDS-related cytomegalovirus ( CMV ) retinitis is evolving because of newly available anti-CMV drugs and because of the effect of potent antiretroviral therapy. New management issues are related to the improve
Discontinuation of maintenance therapy for CMV retinitis in AIDS patients on highly active antiretroviral therapy.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):199-203. Unique Identifier : AIDSLINE MED/20079376; Postelmans L; Gerard M; Sommereijns B; Caspers-Velu L; Department of Ophthalmology, ULB, Brussels, Belgium.; The use of highly active antiretroviral therapy (HAART) has dramatically modified the natural history of cytomegalovirus retinitis (CMVR) in AIDS patients. In this context, we discontinued maintenance therapy in eight AIDS patients with previous CMVR and a good and persistent immun
Management of CMV retinal detachments in the new era of antiretroviral therapy.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):205-13. Unique Identifier : AIDSLINE MED/20079377; Davis JL; Department of Ophthalmology, University of Miami School of; Medicine, Bascom Palmer Eye Institute, Miami, FL 33136, USA.; jdavis@bpei.med.miami.edu; In the past, retinal detachment occurred at a rate of 38% after one year of cytomegalovirus retinitis (CMVR). The current rate of detachment may be reduced by improved therapies for CMVR. In addition, the number of new patients acquiring CMVR has fallen, resulting in a lower incide
Immune recovery uveitis.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):215-21. Unique Identifier : AIDSLINE MED/20079378; Holland GN; Department of Ophthalmology, UCLA Ocular Inflammatory Disease; Center, UCLA School of Medicine, Jules Stein Eye Institute, Los; Angeles, CA 90095-7003, USA.; Potent antiretroviral therapy can result in substantial improvement in the immune function of patients with AIDS. In some patients with preexisting cytomegalovirus ( CMV ) retinitis, a consequence of this improved immune functi
Uveitis in patients treated with intravenous cidofovir.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):223-9. Unique Identifier : AIDSLINE MED/20079379; Cochereau I; Doan S; Diraison MC; Mousalatti H; Guvenisik N; Ren L; Hoang-Xuan T; Service d'Ophthalmologie, H^opital Bichat-Claude Bernard, Paris,; France. oph.sec@bch.ap-hop-paris.fr; PURPOSE: To study the characteristics of uveitis occurring during intravenous cidofovir treatment for CMV retinitis in patients with AIDS. PATIENTS AND METHODS: We retrospectively studied ten cases (16 eyes) of uveitis in patients with CMV retinitis treated with
CMV retinitis in the era of HAART.: Ocul Immunol Inflamm. 1999 Dec;7(3-4):231-5. Unique Identifier : AIDSLINE MED/20079380; Cassoux N; Bodaghi B; Katlama C; LeHoang P; Department of Ophthalmology, Piti:e-Salp^etri`ere Hospital,; Paris, France.; Since 1996, major advances in the treatment of AIDS have markedly changed the incidence and the prognosis of CMV retinitis. Highly active antiretroviral therapy (HAART) is a combination of nucleoside reverse transcriptase inhibitors and
Neovascularization of the optic disc after highly active antiretroviral therapy in an AIDS patient with cytomegalovirus retinitis--A new immune recovery-related ocular disorder?: Ocul Immunol Inflamm. 1999 Dec;7(3-4):237-40. Unique Identifier : AIDSLINE MED/20079381; Postelmans L; Payen MC; De Wit S; Caspers-Velu L; Department of Ophthalmology, ULB, Brussels, Belgium.; A patient with AIDS and cytomegalovirus ( CMV ) retinitis developed a massive bilateral peripheral occlusive vasculopathy with a bilateral neovascularization of the optic disc five weeks after the introduction of highly active
Allogeneic cell therapy in murine B-cell leukemia (BCL1): 2. The role of non-activated and rIL-2-activated CD4+ and CD8+ T cells in immunotherapy for leukemia.: Cytokines Cell Mol Ther. 1999 Sep;5(3):153-8. Unique Identifier : AIDSLINE MED/20104539; Weiss L; Reich S; Slavin S; Department of Bone Marrow Transplantation and Cancer; Immunotherapy and Immunobiology Research Center, Hadassah; University Hospital, Jerusalem, Israel.; Graft-versus-leukemia (GVL) effects play a key role in the elimination of residual leukemia cells in the course of allogeneic bone marrow transplantation (alloBMT). GVL effects can also be induced by donor lymphocyte infusion following alloBMT. We have investigated the role of CD4+ and CD8+ T cells in the development
A new insight into the role of "old" chemotactic peptide receptors FPR and FPRL1: down-regulation of chemokine receptors CCR5 and CXCR4.: Forum (Genova). 1999 Oct-Dec;9(4):299-314. Unique Identifier : AIDSLINE MED/20079398; Le Y; Shen W; Li B; Gong W; Dunlop NM; Wang JM; Laboratory of Molecular Immunoregulation, Division of Basic; Sciences, National Cancer Institute-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702-1201, USA.; N-formyl peptides, such as fMet-Leu-Phe (fMLP), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. In addition to the bacterial peptide fMLP and the putative endogenously produced formylated peptides, we recently identified a number of other novel peptide agonists that selecti
Structure and function of the CC chemokine receptor (CCR) 8.: Forum (Genova). 1999 Oct-Dec;9(4):315-24. Unique Identifier : AIDSLINE MED/20079399; Napolitano M; Santoni A; Laboratorio di Patologia Vascolare, Istituto Dermopatico; dell'Immacolata-IRCCS, Roma, Italy.; The CC chemokine receptor (CCR) 8 belongs to the seven transmembrane-spanning receptor family and functionally responds to the eukaryotic CC chemokines I-309, thymus and activation-regulated chemokine, macrophage inflammatory protein-1 beta (MIP-1b) and to the products viral MIP-I and viral MIP-II of the Kaposi-associ
The role of chemokines in the immunopathology of pulmonary disease.: Forum (Genova). 1999 Oct-Dec;9(4):339-55. Unique Identifier : AIDSLINE MED/20079401; Kunkel SL; Lukacs NW; Strieter RM; Chensue SW; Department of Pathology and Division of Pulmonary and Critical; Care Medicine, University of Michigan Medical School, Ann Arbor,; Michigan 48109-0602, USA.; During the last decade, our understanding of the mechanisms involved in the initiation and maintenance of pulmonary disease has been greatly aided by advances in the field of chemokine biology. Chemokines comprise four supergene families, two of these families (the CC and CXC chemokine groups) are quite large and cont
US to tackle AIDS on the border [news]: Circulation. 2000 Jan 18;101(2):E30. Unique Identifier : AIDSLINE MED/20105762; SoRelle R
Adrenaline-induced mobilization of T cells in HIV-infected patients.: Clin Exp Immunol. 2000 Jan;119(1):115-22. Unique Identifier : AIDSLINE MED/20074841; Sondergaard SR; Cozzi Lepri A; Ullum H; Wiis J; Hermann CK; Laursen SB; Qvist J; Gerstoft J; Skinhoj P; Pedersen BK; Department of Infectious Diseases, Copenhagen Muscle Research; Centre, Copenhagen, Denmark.; The present study aimed to investigate lymphocyte mobilization from peripheral cell reservoirs in HIV-infected patients. Nine HIV-infected patients on stable highly active anti-retroviral therapy (HAART), eight treatment-naive HIV-infected patients and eight HIV- controls received a 1-h adrenaline infusion. The adrena
The thalidomide analogue CC-3052 inhibits HIV-1 and tumour necrosis factor-alpha (TNF-alpha) expression in acutely and chronically infected cells in vitro.: Clin Exp Immunol. 2000 Jan;119(1):123-9. Unique Identifier : AIDSLINE MED/20074842; La Maestra L; Zaninoni A; Marriott JB; Lazzarin A; Dalgleish AG; Barcellini W; Division of Hematology, IRCCS Ospedale Maggiore, Milan, Italy.; We investigated the in vitro effect of the water-soluble, highly stable thalidomide analogue CC-3052 on HIV-1 expression and TNF-alpha production in latently infected promonocytic U1 cells, acutely infected T cells and monocyte-derived human macrophages (MDM), and in mitogen-stimulated ex vivo cultures from patients w
Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production.: Clin Exp Immunol. 2000 Jan;119(1):130-9. Unique Identifier : AIDSLINE MED/20074843; Asakura Y; Liu LJ; Shono N; Hinkula J; Kjerrstrom A; Aoki I; Okuda K; Wahren B; Fukushima J; Department of Bacteriology, Yokohama City University School of; Medeicine, Yokohama, Japan.; The efficacy of DNA-based immunization in conferring protective immunity against certain microbial pathogens including human immunodeficiency virus type 1 (HIV-1) has been described. The potential advantage of DNA-based immunization over the traditional vaccines largely results from its capacity to efficiently induce
Cytokines and soluble cytokine receptor induction after IL-12 administration in cancer patients.: Clin Exp Immunol. 2000 Jan;119(1):28-37. Unique Identifier : AIDSLINE MED/20074830; Haicheur N; Escudier B; Dorval T; Negrier S; De Mulder PH; Dupuy JM; Novick D; Guillot T; Wolf S; Pouillart P; Fridman WH; Tartour E; Unite d'Immunologie Clinique, INSERM 255, Institut Curie, Paris.; This study shows that subcutaneous administration of increasing doses of IL-12, once a week, in 21 cancer patients increased the expression of cytokine genes (interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), IP-10, MIG, IL-10, IL-4) in peripheral blood mononuclear cells even at very low doses (3
Kaposi's sarcoma. New treatment modalities.: Dermatol Clin. 2000 Jan;18(1):169-75, x. Unique Identifier : AIDSLINE MED/20091567; Gascon P; Schwartz RA; Department of Hematology, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark, USA.; Over the last 20 years of experience with the AIDS epidemic, we have accumulated a great body of knowledge on Kaposi s sarcoma (KS), a major cause of morbidity and mortality in AIDS patients, especially among homosexual and bisexual men. New antiretroviral therapies, in particular the
New and emerging therapies in infectious diseases.: Dermatol Clin. 2000 Jan;18(1):31-5, viii. Unique Identifier : AIDSLINE MED/20091554; Harris BD; Adal KA; Tomecki KJ; Department of Dermatology, Cleveland Clinic Foundation, Ohio,; USA.; Infectious diseases account for one-third of all deaths worldwide. The last decade has yielded significant advances in the treatment of infectious skin diseases. This article highlights emerging therapies for viral, fungal, bacterial, and parasitic skin cutaneous infections.
Effect of thalidomide, octreotide, and prednisolone on the migration and proliferation of RPE cells in vitro.: Curr Eye Res. 1999 Dec;19(6):483-90. Unique Identifier : AIDSLINE MED/20019999; Spraul CW; Kaven CK; Kampmeier JK; Lang GK; Lang GE; University of Ulm, Department of Ophthalmology Ulm, Germany.; christoph.spraul@medizin.uni-ulm.de; PURPOSE. The retinal pigment epithelium (RPE) is involved in the pathogenesis of age-related macular degeneration. The purpose of this study was to assess the effect of thalidomide, octreotide, and prednisolone on the proliferation and migration of bovine RPE cells in vitro. METHODS. The migration assay was performed
Delays in tuberculosis isolation and suspicion among persons hospitalized with HIV-related pneumonia.: Chest. 2000 Jan;117(1):110-6. Unique Identifier : AIDSLINE MED/20098427; Bennett CL; Schwartz DN; Parada JP; Sipler AM; Chmiel JS; DeHovitz JA; Goetz MB; Weinstein RA; The Chicago VA Health Care System/Lakeside and Westside; Divisions, Loyola University Medical Center, Chicago, IL 60611,; USA. chenne@nwu.edu; BACKGROUND: Despite awareness of HIV-related tuberculosis (TB), nosocomial outbreaks of multidrug-resistant TB among HIV-infected individuals occur. OBJECTIVE: To investigate delays in TB isolation and suspicion among HIV-infected inpatients discharged with TB or Pneumocystis carinii pneumonia (PCP), common HIV-relate
Mesothelial cells in tuberculous pleural effusions of HIV-infected patients.: Unique Identifier : AIDSLINE MED/20098456; Jones D; Lieb T; Narita M; Hollender ES; Pitchenik AE; Ashkin D; Department of Medicine, University of Miami, Miami, FL, USA.; The scarcity of mesothelial cells is a well-known characteristic of tuberculous pleural effusions. We report three HIV-infected patients with tuberculous pleural effusions, in which mesothelial cells were found in significant numbers in the pleural fluid. Clinicians should be aware that the altered immune responses th
Clinical analysis of Mycobacterium tuberculosis infection in patients with acquired immunodeficiency syndrome.: Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1999 Dec;32(4):250-6. Unique Identifier : AIDSLINE MED/20116269; Chiu CP; Wong WW; Kuo B; Tiao TM; Fung CP; Liu CY; Department of Medicine, National Yang-Ming University, Taiwan,; ROC.; From January 1990 to July 1998, twelve patients (10%) among 120 patients with human immunodeficiency virus infection who were hospitalized in the Veterans General Hospital-Taipei, were proved to have Mycobacterium tuberculosis infection. The mean age of these patients was 38 years, range: 25-62 years. All patients stu
Nutritional supplements combined with dietary counselling diminish whole body protein catabolism in HIV-infected patients.: Eur J Clin Invest. 2000 Jan;30(1):87-94. Unique Identifier : AIDSLINE MED/20086843; Berneis K; Battegay M; Bassetti S; Nuesch R; Leisibach A; Bilz S; Keller U; University Hospital Basel, Switzerland.; BACKGROUND: Weight loss and protein malnutrition are frequent complications in HIV-infected patients. The effect of an oral nutritional supplement combined with nutritional counselling on whole body protein metabolism was assessed. MATERIALS AND METHODS: HIV-infected individuals with a body mass index
Ocular infections in the immunocompromised host.: Dev Ophthalmol. 1999;30:203-19. Unique Identifier : AIDSLINE MED/20093395; Bialasiewiez AA; Knospe V; Richard G; University Eye Hospital Eppendorf, Hamburg, Germany.
[Do general practitioners want to manage chronic hepatitis C and take part in hepatitis C health networks? A national survey]: Gastroenterol Clin Biol. 1999 Dec;23(12):1289-95. Unique Identifier : AIDSLINE MED/20111436; Babany G; Bourliere M; Chevalier H; Chousterman M; Couzigou P; Desmorat H; Dhumeaux D; Doffoel M; Gournay J; Loiseau D; Mercet P; Moussalli J; Trepo C; Tucat G; Doan Tran D; Saint-Marc-Girardin MF; Produits Roche, Neuilly-sur-Seine; Service; d'Hepato-Gastroenterologie, Hopital Saint-Joseph, Marseille;; Taylor Nelson SOFRES Healthcare; Services; d'Hepato-Gastoenterologie, Centre Hospitalie.; OBJECTIVES: To assess information that general practitioners had on hepatitis C and on the hepatitis C network in hospitals and private practice. METHODOLOGY: A national telephone survey of 604 general practitioners was conducted between March 18 and 23, 1998. RESULTS: Screening and management of hepatitis C was impor
[Herpetic esophagitis in human immunodeficiency virus non infected patients]: Gastroenterol Clin Biol. 1999 Dec;23(12):1392-6. Unique Identifier : AIDSLINE MED/20111444; Rosa I; Hagege H; Sommers C; Abd Alsamad I; Gordin J; Lons T; Chousterman M; Service d'Hepato-Gastroenterologie, Service d'Anatomie; Pathologique, Centre Hospitalier Intercommunal, Creteil.; We report five cases of herpetic esophagitis in human immunodeficiency virus non-infected patients. Herpetic esophagitis is a frequent infection in immunocompromised patients. However, sixty four cases of herpetic esophagitis have been reported in immunocompetent patients. The infection presents non-specific esophagea
Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells.: Immunology. 2000 Jan;99(1):1-7. Unique Identifier : AIDSLINE MED/20118132; Tascon RE; Ragno S; Lowrie DB; Colston MJ; Mycobacterial Division, National Institute for Medical Research,; London, UK.; CD8+ T lymphocytes producing high levels of interferon-gamma (IFN-gamma) and expressing antigen specific cytotoxic activity are effectively induced after plasmid DNA vaccination and mediate protection against several intracellular micro-organisms. Recent evidence suggests that the priming of CD8+ T-cell responses foll
Role of beta1 and beta2 subunits of the interleukin-12 receptor in determining T helper 1/T helper 2 responses in vivo in the rat.: Immunology. 2000 Jan;99(1):109-12. Unique Identifier : AIDSLINE MED/20118146; Gillespie KM; Szeto CC; Betin VM; Mathieson PW; Academic Renal Unit, and *Diabetes and Metabolism Unit,; University of Bristol, Southmead Hospital, Bristol, UK.; Interleukin-12 (IL-12) responsiveness, and hence capacity to mount a T helper type 1(Th1) immune response, may be regulated via differential expression of the IL-12 receptor beta2 subunit at least in vitro in human and murine cells. To test whether a similar phenomenon operates in vivo in the rat we cloned and sequenc
The role of endogenous steroid hormones in the generation of T helper 2-mediated autoimmunity in mercuric chloride-treated Brown-Norway rats.: Immunology. 2000 Jan;99(1):141-6. Unique Identifier : AIDSLINE MED/20118150; MacPhee IA; Turner DR; Oliveira DB; Departments of *Renal Medicine and Pathology, St. George's; Hospital Medical School, Cranmer Terrace, London, UK.; Injection of Brown- Norway rats with mercuric chloride (HgCl2) activates a T helper type 2 (Th2) autoimmune response, with production of a number of autoantibodies and vasculitis primarily affecting the gut. Glucocorticoids have been shown to suppress Th1 and to promote the developm
Cellular interactions in bovine tuberculosis: release of active mycobacteria from infected macrophages by antigen-stimulated T cells.: Immunology. 2000 Jan;99(1):23-9. Unique Identifier : AIDSLINE MED/20118135; Li:ebana E; Aranaz A; Aldwell FE; McNair J; Neill SD; Smyth AJ; Pollock JM; Department of Veterinary Science, Queen's University of Belfast,; Belfast, UK.; The outcome of Mycobacterium bovis infections depends on the interactions of infected macrophages with T lymphocytes. Several studies in humans and in mouse models have suggested an important role for cytotoxicity in the protective immune response to mycobacterial infections, and both CD4+ and CD8+ T cells have been s
CD95 ligand expression as a mechanism of immune escape in breast cancer.: Immunology. 2000 Jan;99(1):69-77. Unique Identifier : AIDSLINE MED/20118141; M]uschen M; Moers C; Warskulat U; Even J; Niederacher D; Beckmann MW; Institut Pasteur, Department of Immunology, Unit:e de Biologie; Mol:eculaire du G`ene, Paris, France.; Interaction of CD95 (Apo-1/Fas) and its ligand (CD95L) plays an important role in the regulation of the immune response, since CD95+ lymphocytes may be killed after engagement of the CD95 receptor. Studying the CD95/CD95L system in 40 cases of breast cancer, the malignant cells expressed CD95L, but lost CD95 expressio
Self-priming cell culture system for monitoring genetically-controlled spontaneous cytokine-producing ability in mice.: Immunol Lett. 1999 Dec 1;70(3):173-8. Unique Identifier : AIDSLINE MED/20120463; Sato M; Iwakabe K; Ohta A; Sekimoto M; Kimura S; Nishimura T; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Tokai University School of; Medicine, Kanagawa, Japan.; To monitor genetically-controlled cytokine-producing ability in mice in vitro, we developed a high-density cell culture system, which is preferable for inducing CD4+ T cell-dependent self-priming responses without any antigenic stimulation. When BALB/c spleen cells were cultured at high density (over 1.0 x 10(7) cells
HIV seroprevalence & awareness about AIDS among pregnant women in rural areas of Pune district, Maharashtra, India.: Indian J Med Res. 1999 Oct;110:115-22. Unique Identifier : AIDSLINE MED/20109446; Kunte A; Misra V; Paranjape R; Mansukhani N; Padbidri V; Gonjari S; Kakrani V; Thakar M; Mehendale S; Bharati Vidyapeeth Medical College, Pune.; The present unlinked anonymous study was done among sexually active rural women to assess the extent of spread of HIV and its awareness. Peripheral blood samples were collected on filter paper strips from 1251 pregnant women residing in villages in three Primary Health Centres in Pune district of Maharashtra. Elutes w
Requirement for CD4(+) T lymphocytes in host resistance against Cryptococcus neoformans in the central nervous system of immunized mice.: Infect Immun. 2000 Feb;68(2):456-62. Unique Identifier : AIDSLINE MED/20107042; Buchanan KL; Doyle HA; Department of Microbiology and Immunology, Tulane University; Medical Center, New Orleans, Louisiana 70112, USA.; kbuchan@mailhost.tcs.tulane.edu; The importance of cell-mediated immunity (CMI) and CD4(+) T lymphocytes in host resistance against Cryptococcus neoformans is well documented and is exemplified by the high susceptibility to progressive infection with this pathogen of AIDS patients with reduced CD4(+) T-cell numbers. Although much has been learned abo
Priming of a beta-galactosidase (beta-GAL)-specific type 1 response in BALB/c mice infected with beta-GAL-transfected Leishmania major.: Infect Immun. 2000 Feb;68(2):809-14. Unique Identifier : AIDSLINE MED/20107088; Chakkalath HR; Siddiqui AA; Shankar AH; Dobson DE; Beverley SM; Titus RG; Department of Tropical Public Health, Harvard School of Public; Health, Harvard Medical School, Boston, Massachusetts 02115, USA.; To determine whether an ongoing response to Leishmania major would affect the response to a non-cross-reacting, non-leishmanial antigen, susceptible BALB/c mice and resistant C3H mice were infected with L. major parasites expressing Escherichia coli beta-galactosidase (beta-GAL); this parasite was designated L. major-
Lack of a role of cytotoxic necrotizing factor 1 toxin from Escherichia coli in bacterial pathogenicity and host cytokine response in infected germfree piglets.: Infect Immun. 2000 Feb;68(2):839-47. Unique Identifier : AIDSLINE MED/20107092; Fournout S; Dozois CM; Odin M; Desautels C; Peres S; Herault F; Daigle F; Segafredo C; Laffitte J; Oswald E; Fairbrother JM; Oswald IP; Laboratoire de Pharmacologie Toxicologie, Institut National de; Recherche Agronomique, Toulouse, France.; Some Escherichia coli strains isolated from intestinal or extraintestinal infections in pigs produce cytotoxic necrotizing factor 1 (CNF1). In order to analyze the role of CNF1 in the pathogenesis of porcine colibacillosis, newborn colostrum-deprived germfree piglets were orally inoculated with a wild-type CNF1-produc
Phagocytosed Bordetella pertussis fails to survive in human neutrophils.: Infect Immun. 2000 Feb;68(2):956-9. Unique Identifier : AIDSLINE MED/20107109; Lenz DH; Weingart CL; Weiss AA; Department of Molecular Genetics, Biochemistry, and Microbiology,; University of Cincinnati, Cincinnati, Ohio 45267-0524, USA.; Previous studies have reported that phagocytosed Bordetella pertussis survives in human neutrophils. This issue has been reexamined. Opsonized or unopsonized bacteria expressing green fluorescent protein (GFP) were incubated with adherent human neutrophils. Phagocytosis was quantified by fluorescence microscopy, and t
Intranasal immunization with Toxoplasma gondii SAG1 induces protective cells into both NALT and GALT compartments.: Infect Immun. 2000 Feb;68(2):969-72. Unique Identifier : AIDSLINE MED/20107112; Velge-Roussel F; Marcelo P; Lepage AC; Buzoni-Gatel D; Bout DT; Equipe Associee INRA d'Immunologie Parasitaire-EA 2637, UFR des; Sciences Pharmaceutiques, 37200 Tours, France.; velge@univ-tours.fr; Intranasal (i.n.) immunization with the SAG1 protein of Toxoplasma gondii plus cholera toxin (CT) provides protective immunity. The aim of this study was to analyze the cellular activation of several mucosal compartments after i.n. immunization. Cervical and mesenteric lymph node (CLN and MLN, respectively) lymphoid c
Erythroderma: a comparison between HIV positive and negative patients.: Int J Dermatol. 1999 Dec;38(12):895-900. Unique Identifier : AIDSLINE MED/20098913; Morar N; Dlova N; Gupta AK; Naidoo DK; Aboobaker J; Ramdial PK; Dermatology Department, Faculty of Medicine, University of Natal; and King Edward VII Hospital, Congella, South Africa.; Background Erythroderma has protean underlying causes. There have been isolated case reports suggesting an association between erythroderma and the human immunodeficiency virus (HIV). OBJECTIVE: To describe and characterize further the prevalence, etiology, and metabolic sequelae of erythroderma in HIV positive and ne
Trichloroethylene accelerates an autoimmune response by Th1 T cell activation in MRL +/+ mice.: Immunopharmacology. 2000 Feb;46(2):123-37. Unique Identifier : AIDSLINE MED/20112397; Griffin JM; Blossom SJ; Jackson SK; Gilbert KM; Pumford NR; Department of Pharmacology and Toxicology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; Trichloroethylene (1,1,2-trichloroethene) is a major environmental contaminant. There is increasing evidence relating exposure to trichloroethylene with autoimmunity. To investigate potential mechanisms, we treated the autoimmune-prone MRL +/+ mice with trichloroethylene in the drinking water at 0, 2.5 or 5.0 mg/ml an
Thalidomide's ability to augment the synthesis of IL-2 in vitro in HIV-infected patients is associated with the percentage of CD4+ cells in their blood.: Immunopharmacology. 2000 Feb;46(2):175-9. Unique Identifier : AIDSLINE MED/20112401; Shannon E; Aseffa A; Pankey G; Sandoval F; Lutz B; Gillis W. Long Hansen's Dis. Ctr. Lab, Research Branch at; Louisianna State University, Baton Rouge 70894, USA.; Thalidomide is used for treating erythema nodosum leprosum. It is also used to treat aphthous ulcers in HIV-infected patients. The mechanism of action of this drug is yet to be fully understood, but modulation of inflammatory cytokines like IL-2 and TNF-alpha may play
The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.: J Cell Biol. 1999 Dec 27;147(7):1379-84. Unique Identifier : AIDSLINE MED/20082876; Doria M; Salcini AE; Colombo E; Parslow TG; Pelicci PG; Di Fiore PP; Department of Experimental Oncology, European Institute of; Oncology, 20141 Milan, Italy.; The Eps15 homology (EH) module is a protein-protein interaction domain that establishes a network of connections involved in various aspects of endocytosis and sorting. The finding that EH-containing proteins bind to Hrb (a cellular cofactor of the Rev protein) and to the related protein Hrbl raised the possibility th
Risks associated with tattooing and body piercing.: J Public Health Policy. 1999;20(4):459-70. Unique Identifier : AIDSLINE MED/20107783; Braithwaite RL; Stephens T; Sterk C; Braithwaite K; Department of Behavioral Sciences and Health Education, Rollins; School of Public Health of Emory University, Atlanta, Georgia; 30322, USA.; The purpose of this article is to highlight the importance of including cosmetic body-piercing and tattooing in HIV prevention and education. Little information about risks associated with tattoos or having one s body pierced is evident in the health promotion and disease prevention literature, particularly among adol
Chemokine production by the BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines.: J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):126-33. Unique Identifier : AIDSLINE MED/20096653; Fujisawa T; Kato Y; Atsuta J; Terada A; Iguchi K; Kamiya H; Yamada H; Nakajima T; Miyamasu M; Hirai K; Department of Pediatrics, Mie National Hospital, Tsu, Japan.; BACKGROUND: Bronchial epithelial cells produce many types of chemokines and may contribute to lung inflammation by recruiting inflammatory cells. The CC chemokine eotaxin is a potent, eosinophil-specific chemoattractant that has been detected in the bronchial epithelium of patients with asthma. OBJECTIVES: The aim of
Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I).: J Emerg Med. 2000 Jan;18(1):109-19. Unique Identifier : AIDSLINE MED/20108448; Edlich RF; Arnette JA; Williams FM; Department of Plastic Surgery, University of Virginia School of; Medicine, Charlottesville 22908, USA.; Infection with human T-cell lymphotrophic virus-I (HTLV-I) is now a global epidemic, affecting 10 million to 20 million people. This virus has been linked to life-threatening, incurable diseases: adult T-cell leukemia/lymphoma (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The cumulati
Re: Emergency Department management of occupational exposures to HIV-infected fluids [letter]: J Emerg Med. 2000 Jan;18(1):121-2. Unique Identifier : AIDSLINE MED/20108449; Evans DW
Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock.: J Immunol. 2000 Jan 15;164(2):1013-9. Unique Identifier : AIDSLINE MED/20090895; Hasko G; Kuhel DG; Nemeth ZH; Mabley JG; Stachlewitz RF; Virag L; Lohinai Z; Southan GJ; Salzman AL; Szabo C; Inotek Corp., Beverly, MA 01915, USA. ghasko@inotekcorp.com; Extracellular purines, including adenosine and ATP, are potent endogenous immunomodulatory molecules. Inosine, a degradation product of these purines, can reach high concentrations in the extracellular space under conditions associated with cellular metabolic stress such as inflammation or ischemia. In the present stu
Therapeutic potential of phosphodiesterase-4 and -3 inhibitors in Th1-mediated autoimmune diseases.: J Immunol. 2000 Jan 15;164(2):1117-24. Unique Identifier : AIDSLINE MED/20090908; Bielekova B; Lincoln A; McFarland H; Martin R; Neuroimmunology Branch, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda, MD; 20892, USA.; Phosphodiesterase-4 (PDE4) inhibitors have the potential to modulate immune responses from the Th1 toward the Th2 phenotype and are considered candidate therapies for Th1-mediated autoimmune disorders. However, depending on the model and cell types employed, studies of atopic individuals have come to the opposite conc
Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen.: J Immunol. 2000 Jan 15;164(2):562-5. Unique Identifier : AIDSLINE MED/20090839; Surman DR; Dudley ME; Overwijk WW; Restifo NP; Surgery Branch, National Cancer Institute, Bethesda, MD 20892,; USA.; Neoantigens resulting from the inherent genomic instability of tumor cells generally do not trigger immune recognition. Similarly, transfection of tumors with model Ags often fails to elicit CD8+ T cell responses or alter a tumor s growth rate or lethality. We report here that the adoptive transfer of activated Th1-ty
Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide.: J Immunol. 2000 Jan 15;164(2):580-8. Unique Identifier : AIDSLINE MED/20090842; Janssen EM; van Oosterhout AJ; van Rensen AJ; van Eden W; Nijkamp FP; Wauben MH; Institute of Infectious Diseases, Department of Immunology,; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The; Netherlands.; Allergen-specific CD4+ Th2 cells play an important role in the immunological processes of allergic asthma. Previously we have shown that, by using the immunodominant epitope OVA323-339, peptide immunotherapy in a murine model of OVA induced allergic asthma, stimulated OVA-specific Th2 cells, and deteriorated airway hy
HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE.: J Immunol. 2000 Jan 15;164(2):589-95. Unique Identifier : AIDSLINE MED/20090843; Patella V; Florio G; Petraroli A; Marone G; University of Naples Federico II, Division of Clinical Immunology; and Allergy, Naples, Italy.; HIV-1 glycoprotein (gp) 120 from different clades is a potent stimulus for IL-4 and IL-13 release from basophils purified from healthy individuals seronegative for Abs to HIV-1 and HIV-2. IL-4 mRNA, constitutively present in basophils, was increased after stimulation by gp120 and was inhibited cyclosporin A and tacrol
Analysis of the requirements for the induction of CD4+ T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody.: Unique Identifier : AIDSLINE MED/20090846; Taylor PA; Panoskaltsis-Mortari A; Noelle RJ; Blazar BR; A major goal of the transplant field is to selectively tolerize only those donor T cells recognizing host alloantigen and mediating graft-vs-host disease (GVHD). Recently, we described an
The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity.: J Immunol. 2000 Jan 15;164(2):656-63. Unique Identifier : AIDSLINE MED/20090851; Hill GR; Teshima T; Rebel VI; Krijanovski OI; Cooke KR; Brinson YS; Ferrara JL; Department of Pediatric Oncology, Dana-Farber Cancer Institute,; Harvard Medical School, Boston, MA 02115, USA.; TNF-alpha is known to be an important mediator of tissue damage during allograft rejection and graft-vs-host disease (GVHD), but its role in supporting T cell responses to allogeneic Ags is unclear. We have studied this question by comparing normal mice with those lacking the p55 (p55 TNFR-/-) or p75 (p75 TNFR-/-) TNF
Blockade of CTLA-4 signals inhibits Th2-mediated murine chronic graft-versus-host disease by an enhanced expansion of regulatory CD8+ T cells.: J Immunol. 2000 Jan 15;164(2):664-9. Unique Identifier : AIDSLINE MED/20090852; Sakurai J; Ohata J; Saito K; Miyajima H; Hirano T; Kohsaka T; Enomoto S; Okumura K; Azuma M; Department of Immunology, National Children's Medical Research; Center, Tokyo, Japan.; CTLA-4 (CD152) is thought to be a negative regulator of T cell activation. Little is known about the function of CTLA-4 in Th2-type immune responses. We have investigated the effect of initial treatment with anti-CTLA-4 mAb on murine chronic graft-vs-host disease. Transfer of parental BALB/c splenocytes into C57BL/6 x
Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells.: J Immunol. 2000 Jan 15;164(2):725-32. Unique Identifier : AIDSLINE MED/20090860; Lefrancois L; Altman JD; Williams K; Olson S; Division of Rheumatic Diseases, University of Connecticut Health; Center, Farmington, CT 06037, USA. llefranc@panda.uchc.edu; The signals directing induction of tolerance rather than immunity are largely unknown. The CD8 T cell response to soluble Ags generally results in deletional tolerance following transient, costimulation-dependent activation. We demonstrated that CD40 signaling reversed the outcome of this response. Adoptive transfer o
Comparative contribution of CD1 on the development of CD4+ and CD8+ T cell compartments.: J Immunol. 2000 Jan 15;164(2):739-45. Unique Identifier : AIDSLINE MED/20090862; Wang B; Chun T; Wang CR; Gwen Knapp Center for Lupus, Committee on Immunology, University; of Chicago, Chicago, IL 60637, USA.; CD1 molecules are MHC class I-like glycoproteins whose expression is essential for the development of a unique subset of T cells, the NK T cells. To evaluate to what extent CD1 contributes to the development of CD4+ and CD8+ T cells, we generated CD1oIIo and CD1oTAPo mice and compared the generation of T cells in thes
The multidrug resistance protein 1: a functionally important activation marker for murine Th1 cells.: Unique Identifier : AIDSLINE MED/20090864; Prechtl S; Roellinghoff M; Scheper R; Cole SP; Deeley RG; Lohoff M; Institut fur Klinische Mikrobiologie und Immunologie,; Previously, we described the expression of an energy-dependent pump in resting murine Th2 (but not resting Th1) cells which extruded the fluorescent dye Fluo-3. After stimulation with Ag and APCs, Th1 cells also expressed this pump. Furthermore, expression of the murine multidrug resistance protein 1 (mrp1) correlated
IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs.: J Immunol. 2000 Jan 15;164(2):779-85. Unique Identifier : AIDSLINE MED/20090867; Martin DL; King CL; Pearlman E; Strine E; Heinzel FP; Department of Pathology, Division of Geographic Medicine, Case; Western Reserve University School of Medicine, Cleveland, OH; 44106, USA.; The injection of Schistosoma mansoni eggs into the footpads of mice results in a localized Th2 cytokine response and tissue eosinophilia. We examined whether treatment with CD40-activating Abs would block the development of Th2 cytokine responses and eosinophilic tissue pathology in this model. Seven days after C57BL/
Extension of HLA-A*0201-restricted minimal epitope by N epsilon-palmitoyl-lysine increases the life span of functional presentation to cytotoxic T cells.: J Immunol. 2000 Jan 15;164(2):900-7. Unique Identifier : AIDSLINE MED/20090882; Loing E; Andrieu M; Thiam K; Schorner D; Wiesmuller KH; Hosmalin A; Jung G; Gras-Masse H; Unite Mixte de Recherche 8525, Centre National de la Recherche; Scientifique-Lille II University and Institut Pasteur de Lille,; Lille, France. Estelle.Loing@pasteur-lille.fr; The delineation of the minimal requirements for efficient delivery of functional cytotoxic epitopes into APC could be a step toward the definition of minimal length lipopeptides for the modulation of CTL activity. Several analogues of the HLA-A*0201-restricted HIV-1 polymerase (pol476-484) minimal cytotoxic epitope
Type 1 and type 2 CD8+ effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumor.: Unique Identifier : AIDSLINE MED/20090884; Dobrzanski MJ; Reome JB; Dutton RW; Trudeau Institute, Saranac Lake, NY 12983, USA.; Cytolytic CD8+ effector cells fall into two subpopulations based on cytokine secretion. Type 1 CD8+ T cells (Tc1) secrete IFN-gamma, whereas type 2 CD8+ T cells (Tc2) secrete IL-4, IL-5, and IL-10. Using an OVA-transfected B16 lung metastases model, we assessed the therapeutic effects of adoptively transferred OVA-spe
Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection.: J Immunol. 2000 Jan 15;164(2):934-43. Unique Identifier : AIDSLINE MED/20090886; Kaur A; Yang J; Hempel D; Gritz L; Mazzara GP; McClure H; Johnson RP; Division of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, MA 01772, USA.; amitinder_kaur@hms.harvard.edu; Host immune responses to SIV infection in sooty mangabeys are likely to be an important determinant of how such nonhuman primate species maintain asymptomatic lentivirus infection. We have previously described two patterns of asymptomatic SIV infection in sooty mangabeys: low viral loads with vigorous SIV-specific CTL
CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism.: BIOSYNTHESIS Schistosoma mansoni/*IMMUNOLOGY Support, Non-U.S. Gov't Th2 Cells/*IMMUNOLOGY/METABOLISM/PARASITOLOGY Up-Regulation (Physiology)/IMMUNOLOGY J Immunol. 2000 Jan 15;164(2):973-85. Unique Identifier : AIDSLINE MED/20090891; Chiaramonte MG; Hesse M; Cheever AW; Wynn TA; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, MD 20892, USA.
[Preventive effect of postoperative disinfection of endoscope on bacterial adhesion to endoscope]: Kansenshogaku Zasshi. 1999 Oct;73(10):1019-24. Unique Identifier : AIDSLINE MED/20030354; Uwagawa T; Okabe N; Matsumoto T; Kurihara H; Miyamoto S; Tujihara Y; Takahashi T; Sakurai I; Matsumoto F; Yamazaki Y; Department of Surgery, Kanagawa Prefecture Midwives and Nurses; Training School Hospital.; We took culture of throat swab from 77 subjects who were negative for infection of HBV, HCV, HIV and syphilis infection before and after endoscopy. Moreover, the existence of bacterium including Helicobacter pylori at overcoat of endoscopic instrument was investigated right after examination and after disinfection of
Influence of protease inhibitor therapy on lipoprotein metabolism.: J Intern Med. 1999 Dec;246(6):567-75. Unique Identifier : AIDSLINE MED/20086967; Berthold HK; Parhofer KG; Ritter MM; Addo M; Wasmuth JC; Schliefer K; Spengler U; Rockstroh JK; Department of Internal Medicine I, University of Bonn, Germany.; berthold@uni-bonn.de; OBJECTIVES: Protease inhibitors are efficient drugs as part of highly active antiretroviral therapy. They have been shown to cause hyper- and dyslipoproteinemia. Since antiretroviral therapy is able to delay disease progression and possibly extend life expectancy in HIV-infected individuals, the precise nature of seru
Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo.: J Exp Med. 2000 Jan 3;191(1):157-70. Unique Identifier : AIDSLINE MED/20088901; Nishimura H; Yajima T; Naiki Y; Tsunobuchi H; Umemura M; Itano K; Matsuguchi T; Suzuki M; Ohashi PS; Yoshikai Y; Laboratory of Host Defense & Germfree Life, Research Institute; for Disease Mechanism and Control, Nagoya University School of; Medicine, Nagoya 466, Japan. nishihit@med.nagoya-u.ac.jp; At least two types of interleukin (IL)-15 mRNA isoforms are generated by alternative splicing at the 5 upstream of exon 5 in mice. To elucidate the potential roles of IL-15 isoforms in immune responses in vivo, we constructed two groups of transgenic mice using originally described IL-15 cDNA with a normal exon 5 (no
Specificity of platinum-DNA adduct repair.: J Inorg Biochem. 1999 Oct;77(1-2):71-81. Unique Identifier : AIDSLINE MED/20091802; Chaney SG; Vaisman A; Department of Biochemistry and Biophysics, School of Medicine,; University of North Carolina, Chapel Hill 27599-7260, USA.; Stephen_Chaney@med.unc.edu; Cell lines with resistance to cisplatin and carboplatin often retain sensitivity to platinum complexes with different carrier ligands (e.g., oxaliplatin and JM216). HeLa cell extracts were shown to excise cisplatin, oxaliplatin, and JM216 adducts with equal efficiency, suggesting that nucleotide excision repair does n
HIV antibody profiles in serum and CSF of patients with neurological disease can serve as predictors of outcome.: J Neurol Neurosurg Psychiatry. 2000 Jan;68(1):86-8. Unique Identifier : AIDSLINE MED/20069979; Desai A; Ravi V; Satishchandra P; Khanna N; Rao S; Gourie-Devi M; Chandramuki A; Department of Neurovirology, Neurology, Neuromicrobiology, and; Biostatistics, National Institute of Mental Health and Neuro; Sciences (NIMHANS), Bangalore 560029, India.; The serum and CSF antibody profiles were investigated in 100 patients with HIV in relation to the type and severity of neurological disease. Among them, 87 were positive for anti-HIV antibodies in the CSF. In 30 of 87 patients detailed analysis by western blot could be performed. In 20 of 30 the profiles were dissimil
A human milk factor susceptible to cathepsin D inhibitors enhances human immunodeficiency virus type 1 infectivity and allows virus entry into a mammary epithelial cell line.: J Virol. 2000 Jan;74(2):1004-7. Unique Identifier : AIDSLINE MED/20091357; El Messaoudi K; Thiry LF; Liesnard C; Van Tieghem N; Bollen A; Moguilevsky N; Department of Applied Genetics, Faculty of Science, Universite; Libre de Bruxelles, Brussels, Belgium. Kelmessa@sga.ulb.ac.be; Human immunodeficiency virus type 1 (HIV-1) growth in lymphocyte cultures was increased when the virus inoculum was incubated in breast milk. The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cathepsin D inhibitor. The cathepsin D-producing CD4-negative MCF7 mammary cells sup
Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells.: J Virol. 2000 Jan;74(2):1018-22. Unique Identifier : AIDSLINE MED/20091360; Spiegel HM; Ogg GS; DeFalcon E; Sheehy ME; Monard S; Haslett PA; Gillespie G; Donahoe SM; Pollack H; Borkowsky W; McMichael AJ; Nixon DF; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; CD4(+) T cells are thought to be critical in the maintenance of virus-specific CD8(+) cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in HIV-1-specific CTL as the CD4(+) T-cell count decreases has been reported. Using HLA-peptide tetrameric complexes, we
High-level resistance to 3'-azido-3'-deoxythimidine due to a deletion in the reverse transcriptase gene of human immunodeficiency virus type 1.: J Virol. 2000 Jan;74(2):1023-8. Unique Identifier : AIDSLINE MED/20091361; Imamichi T; Sinha T; Imamichi H; Zhang YM; Metcalf JA; Falloon J; Lane HC; SAIC Frederick, Frederick Cancer Research and Development Center,; National Cancer Institute, Frederick, Bethesda, Maryland 20892,; USA.; A variant of human immunodeficiency virus type 1 (HIV-1) possessing a deletion in the reverse transcriptase (RT) gene at codon 67 was identified in a patient who had failed combination antiretroviral therapy. This deletion initially emerged under the selective pressure of
Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.: J Virol. 2000 Jan;74(2):1029-32. Unique Identifier : AIDSLINE MED/20091362; Pereira RA; Simon MM; Simmons A; Infectious Diseases Laboratories, Institute of Medical and; Veterinary Science, Adelaide, South Australia 5000, Australia.; Rosemary.Pereira@imvs.sa.gov.au; Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that granzyme A restrict
The human herpesvirus 8 homolog of Epstein-Barr virus SM protein (KS-SM) is a posttranscriptional activator of gene expression.: J Virol. 2000 Jan;74(2):1038-44. Unique Identifier : AIDSLINE MED/20091364; Gupta AK; Ruvolo V; Patterson C; Swaminathan S; Sealy Center for Oncology and Hematology, Department of Internal; Medicine and Department of Microbiology and Immunology,; University of Texas Medical Branch, Galveston, Texas 77555, USA.; Homologs of the Epstein-Barr virus (EBV) SM protein exist in several human and nonhuman herpesviruses. Structure and function differ significantly among these proteins. We have cloned and characterized the human herpesvirus 8 (HHV8) gene, KS-SM, which is homologous to the EBV SM and herpes simplex virus ICP27 genes, f
A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses.: J Virol. 2000 Jan;74(2):619-26. Unique Identifier : AIDSLINE MED/20091316; Shimizu N; Soda Y; Kanbe K; Liu HY; Mukai R; Kitamura T; Hoshino H; Department of Virology and Preventive Medicine, Gunma University; School of Medicine, Maebashi, Gunma 371-8511, Japan.; More than 10 G protein-coupled receptors (GPCRs) have been shown to act as coreceptors for infection of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV). We have isolated HIV-1 variants infectious to primary brain-derived CD4-positive cells (BT-3 and BT-20/N) and U87/CD4 glio
A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure.: J Virol. 2000 Jan;74(2):627-43. Unique Identifier : AIDSLINE MED/20091317; Binley JM; Sanders RW; Clas B; Schuelke N; Master A; Guo Y; Kajumo F; Anselma DJ; Maddon PJ; Olson WC; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; The few antibodies that can potently neutralize human immunodeficiency virus type 1 (HIV-1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious virions. These native envelope glycoprotein complexes comprise three gp120 subunits noncovalently and weakly associated with three gp41 moieti
Cell cycle-regulated transcription by the human immunodeficiency virus type 1 Tat transactivator.: Unique Identifier : AIDSLINE MED/20091319; Kashanchi F; Agbottah ET; Pise-Masison CA; Mahieux R; Duvall J; Kumar A; Brady JN; Cyclin-dependent kinases are required for the Tat-dependent transition from abortive to productive elongation. Further, the human immunodeficiency virus type 1 (HIV-1) Vpr protein prevents proliferation of infected cells by arresting them in the G(2) phase of the cell cycle. These findings suggest that the life cycle
Anti-feline immunodeficiency virus (FIV) soluble factor(s) produced from antigen-stimulated feline CD8(+) T lymphocytes suppresses FIV replication.: J Virol. 2000 Jan;74(2):676-83. Unique Identifier : AIDSLINE MED/20091322; Choi IS; Hokanson R; Collisson EW; Department of Veterinary Pathobiology, Texas A&M University,; College Station, Texas 77843-4467, USA.; Feline immunodeficiency virus (FIV) causes AIDS-like symptoms in infected cats. Concanavalin A (ConA)-stimulated peripheral blood mononuclear cells (PBMC) from chronically FIV strain PPR-infected cats readily expressed FIV. In contrast, when PBMC from these animals were stimulated with irradiated, autologous antigen-p
Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.: J Virol. 2000 Jan;74(2):684-92. Unique Identifier : AIDSLINE MED/20091323; Gustafson EA; Schinazi RF; Fingeroth JD; Divisions of Infectious Disease and Experimental Medicine, Beth; Israel Deaconess Medical Center, Boston, Massachusetts 02115,; USA.; Human herpesvirus 8 (HHV8) open reading frame (ORF) 21 is predicted to encode a protein similar to the thymidine kinase (TK) enzyme of other herpesviruses. Expressed in mammalian cells, ORF 21 was found to have low TK activity, based on poor growth in media containing hypoxanthine-aminopterin-thymidine (HAT) and low i
Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domains.: J Virol. 2000 Jan;74(2):693-701. Unique Identifier : AIDSLINE MED/20091324; Shieh JT; Martin J; Baltuch G; Malim MH; Gonzalez-Scarano F; Department of Neurology, University of Pennsylvania Medical; Center, Philadelphia, Pennsylvania, USA.; Microglia are the main reservoir for human immunodeficiency virus type 1 (HIV-1) in the central nervous system (CNS), and multinucleated giant cells, the result of fusion of HIV-1-infected microglia and brain macrophages, are the neuropathologic hallmark of HIV dementia . One potent
Epstein-Barr virus recombinants from BC-1 and BC-2 can immortalize human primary B lymphocytes with different levels of efficiency and in the absence of coinfection by Kaposi's sarcoma-associated herpesvirus.: J Virol. 2000 Jan;74(2):735-43. Unique Identifier : AIDSLINE MED/20091328; Aguirre AJ; Robertson ES; Department of Microbiology and Immunology, University of Michigan; Medical School, Ann Arbor, Michigan 48109-0620, USA.; Epstein-Barr virus (EBV) and Kaposi s sarcoma-associated herpesvirus (KSHV) are human gammaherpesviruses associated with numerous malignancies. Primary effusion lymphoma or body cavity-based lymphoma is a distinct clinicopathological entity that, in the majority of cases, manifests coinfection with KSHV and EBV. In pr
A cell-line-specific defect in the intracellular transport and release of assembled retroviral capsids.: Unique Identifier : AIDSLINE MED/20091333; Parker SD; Hunter E; Retrovirus assembly involves a complex series of events in which a large number of proteins must be targeted to a point on the plasma membrane where immature viruses bud from the cell. Gag polyproteins of most retroviruses assemble an immature capsid on the cytoplasmic side of the plasma membrane during the budding pr
Characterization of an internal ribosomal entry segment in the 5' leader of murine leukemia virus env RNA.: J Virol. 2000 Jan;74(2):846-50. Unique Identifier : AIDSLINE MED/20091340; Deffaud C; Darlix JL; LaboRetro, Unite de Virologie Humaine, Institut National de la; Sante et de la Recherche Medicale U412, Ecole Normale; Superieure de Lyon, 69364 Lyon Cedex 07, France.; The 5 untranslated region, also called the leader, of oncoretroviruses and lentiviruses is long and is formed of several structured domains critically important in virus replication. The 5 leader of murine leukemia virus (MLV) RNA contains an internal ribosomal entry segment (IRES) which promotes synthesis of Gag an
Interactions between equine cyclin T1, Tat, and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1.: J Virol. 2000 Jan;74(2):892-8. Unique Identifier : AIDSLINE GENBANK; Taube R; Fujinaga K; Irwin D; Wimmer J; Geyer M; Peterlin BM; Howard Hughes Medical Institute, Departments of Medicine,; Microbiology, and Immunology, University of California at San; Francisco, San Francisco, California 94143-0703, USA.; Transcriptional transactivators (Tat) from human immunodeficiency and equine infectious anemia viruses (HIV and EIAV) interact with their transactivation response elements (TAR) to increase the rates of viral transcription. Whereas the human cyclin T1 is required for the binding of Tat to TAR from HIV, it is unknown h
Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine.: J Virol. 2000 Jan;74(2):923-33. Unique Identifier : AIDSLINE MED/20091348; Ramirez JC; Gherardi MM; Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de; Biotecnologia, CSIC, Campus Universidad Autonoma, 28049 Madrid,; Spain.; The modified vaccinia virus Ankara (MVA) strain is a candidate vector for vaccination against pathogens and tumors, due to safety concerns and the proven ability of recombinants based on this vector to trigger protection against pathogens in animals. In this study we addressed the fate of the MVA vector in BALB/c mice
A group of V3 sequences from human immunodeficiency virus type 1 subtype E non-syncytium-inducing, CCR5-using variants are resistant to positive selection pressure.: J Virol. 2000 Feb;74(3):1069-78. Unique Identifier : AIDSLINE +; Shiino T; Kato K; Kodaka N; Miyakuni T; Takebe Y; Sato H; Laboratory of Molecular Virology and Epidemiology, AIDS Research; Center, National Institute of Infectious Diseases, Shinjuku,; Tokyo 162-8640, Japan. tshiino@nih.go.jp; In a human immunodeficiency virus type 1 (HIV-1)-infected individual, immune-pressure-mediated positive selection operates to maintain the antigenic polymorphism on the gp120 third variable (V3) loop. Recently, we suggested on the basis of sequencing C2/V3 segments from an HIV-1 subtype E-infected family that a V3 seq
Functional role of pX open reading frame II of human T-lymphotropic virus type 1 in maintenance of viral loads in vivo.: J Virol. 2000 Feb;74(3):1094-100. Unique Identifier : AIDSLINE MED/20094895; Bartoe JT; Albrecht B; Collins ND; Robek MD; Ratner L; Green PL; Lairmore MD; Center for Retrovirus Research and Department of Veterinary; Biosciences, The Ohio State University, Columbus, Ohio; 43210-1093, USA.; Human T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and is associated with a variety of immune-mediated disorders. The role of four open reading frames (ORFs), located between env and the 3 long terminal repeat of HTLV-1, in mediating disease is not entirely clear. By differential splicin
The explosive human immunodeficiency virus type 1 epidemic among injecting drug users of Kathmandu, Nepal, is caused by a subtype C virus of restricted genetic diversity.: J Virol. 2000 Feb;74(3):1149-57. Unique Identifier : AIDSLINE +; Oelrichs RB; Shrestha IL; Anderson DA; Deacon NJ; AIDS Molecular Biology Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield, Victoria 3078, Australia.; oelrichs@loxinfo.co.th; An explosive epidemic of human immunodeficiency virus type 1 (HIV-1) has been documented among the injecting drug user population of Kathmandu, Nepal , whose seropositivity rate has risen from 0 to 40% between 1995 and 1997. By using
Biochemical and structural analysis of isolated mature cores of human immunodeficiency virus type 1.: J Virol. 2000 Feb;74(3):1168-77. Unique Identifier : AIDSLINE MED/20094903; Welker R; Hohenberg H; Tessmer U; Huckhagel C; Krausslich HG; Heinrich-Pette-Institut fur experimentelle Virologie und; Immunologie an der Universitat Hamburg, D-20251 Hamburg,; Germany.; Mature human immunodeficiency virus type 1 (HIV-1) particles contain a cone-shaped core structure consisting of the internal ribonucleoprotein complex encased in a proteinaceous shell derived from the viral capsid protein. Because of their very low stability after membrane removal, HIV-1 cores have not been purified i
Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection.: J Virol. 2000 Feb;74(3):1209-23. Unique Identifier : AIDSLINE GENBANK/AF148481; Chakrabarti LA; Lewin SR; Zhang L; Gettie A; Luckay A; Martin LN; Skulsky E; Ho DD; Cheng-Mayer C; Marx PA; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA. chakra@adarc.org; Sooty mangabeys naturally infected with simian immunodeficiency virus (SIV) remain healthy though they harbor viral loads comparable to those in rhesus macaques that progress to AIDS. To assess the immunologic basis of disease resistance in mangabeys, we compared the effect of SIV infection on T-cell regeneration in b
High rate of recombination throughout the human immunodeficiency virus type 1 genome.: J Virol. 2000 Feb;74(3):1234-40. Unique Identifier : AIDSLINE MED/20094909; Jetzt AE; Yu H; Klarmann GJ; Ron Y; Preston BD; Dougherty JP; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, Piscataway, New Jersey 08854, USA.; The diploid nature of human immunodeficiency virus type 1 (HIV-1) indicates that recombination serves a central function in virus replication and evolution. Previously, while examining the nature of obligatory primer strand transfers during reverse transcription, a high rate of recombination was observed at the ends o
Marking and gene expression by a lentivirus vector in transplanted human and nonhuman primate CD34(+) cells.: J Virol. 2000 Feb;74(3):1286-95. Unique Identifier : AIDSLINE MED/20094915; An DS; Wersto RP; Agricola BA; Metzger ME; Lu S; Amado RG; Chen IS; Donahue RE; UCLA AIDS Institute, University of California, Los Angeles, USA.; Recently, gene delivery vectors based on human immunodeficiency virus (HIV) have been developed as an alternative mode of gene delivery. These vectors have a number of advantages, particularly in regard to the ability to infect cells which are not actively dividing. However, the use of vectors based on human immunodef
Avian endogenous retrovirus EAV-HP shares regions of identity with avian leukosis virus subgroup J and the avian retrotransposon ART-CH.: J Virol. 2000 Feb;74(3):1296-306. Unique Identifier : AIDSLINE GENBANK/AJ238125; Sacco MA; Flannery DM; Howes K; Venugopal K; Institute for Animal Health, Compton, Newbury, Berkshire RG20; 7NN, United Kingdom.; The existence of novel endogenous retrovirus elements in the chicken genome, designated EAV-HP, with close sequence identity to the env gene of avian leukosis virus (ALV) subgroup J has been reported (L. M. Smith, A. A. Toye, K. Howes, N. Bumstead, L. N. Payne, and K. Venugopal, J. Gen. Virol. 80:261-268, 1999). To re
A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination.: J Virol. 2000 Feb;74(3):1415-24. Unique Identifier : AIDSLINE MED/20094928; Lane TE; Liu MT; Chen BP; Asensio VC; Samawi RM; Paoletti AD; Campbell IL; Kunkel SL; Fox HS; Buchmeier MJ; Department of Molecular Biology and Biochemistry, University of; California-Irvine, Irvine, California. tlane@uci.edu; Infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in a demyelinating encephalomyelitis characterized by mononuclear cell infiltration and white matter destruction similar to the pathology of the human demyelinating disease multiple sclerosis. The contributions of CD4(+) and CD8(+) T cells in the patho
A novel truncated env gene isolated from a feline leukemia virus-induced thymic lymphosarcoma.: J Virol. 2000 Feb;74(3):1451-6. Unique Identifier : AIDSLINE MED/20094932; Shi Y; Roy-Burman P; Department of Pathology, University of Southern California School; of Medicine, Los Angeles, California 90033, USA.; We PCR amplified the exogenous feline leukemia virus (FeLV)-related env gene species from lymphosarcomas induced by intradermally administered plasmid DNA of either the prototype FeLV, subgroup A molecular clone, F6A, or a new molecular clone, FeLV-A, Rickard strain (FRA). Of the nine tumors examined, six showed the p
Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections.: J Virol. 2000 Feb;74(3):1495-505. Unique Identifier : AIDSLINE GENBANK/AF082498; Guo JT; Zhou H; Liu C; Aldrich C; Saputelli J; Whitaker T; Barrasa MI; Mason WS; Seeger C; Institute for Cancer Research, Fox Chase Cancer Center,; Philadelphia, Pennsylvania 19111, USA.; It is well known that hepatitis B virus infections can be transient or chronic, but the basis for this dichotomy is not known. To gain insight into the mechanism responsible for the clearance of hepadnavirus infections, we have performed a molecular and histologic analysis of liver tissues obtained from transiently in
Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo.: J Virol. 2000 Feb;74(3):1554-7. Unique Identifier : AIDSLINE MED/20094945; Popper SJ; Sarr AD; Gueye-Ndiaye A; Mboup S; Essex ME; Kanki PJ; Department of Immunology and Infectious Diseases and the Harvard; AIDS Institute, Harvard School of Public Health, Boston,; Massachusetts.; Levels of virus in the plasma are closely related to the pathogenicity of human immunodeficiency virus type 1 (HIV-1). HIV-2 is much less pathogenic than HIV-1, and infection with HIV-2 leads to significantly lower plasma viral load. To identify the source of this difference, we measured both viral RNA and proviral DN
Papio cynocephalus endogenous retrovirus among old world monkeys: evidence for coevolution and ancient cross-species transmissions.: J Virol. 2000 Feb;74(3):1578-86. Unique Identifier : AIDSLINE GENBANK/AF142988; Mang R; Maas J; van Der Kuyl AC; Goudsmit J; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, Amsterdam, The Netherlands.; r.mang@amc.uva.nl; To study the evolutionary history of Papio cynocephalus endogenous retrovirus (PcEV), we analyzed the distribution and genetic characteristics of PcEV among 17 different species of primates. The viral pol-env and long terminal repeat and untranslated region (LTR-UTR) sequences could be recovered from all Old World spe
Chimpanzees as original source for HIV.: JAMA. 2000 Jan 19;283(3):310. Unique Identifier : AIDSLINE MED/20112309; Folks TM; HIV and Retrovirology Branch, National Center for Infectious; Diseases, Centers for Disease Control and Prevention, Atlanta,; GA, USA. tmf2@cdc.gov
Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel.: JAMA. 2000 Jan 19;283(3):381-90. Unique Identifier : AIDSLINE MED/20112328; Carpenter CC; Cooper DA; Fischl MA; Gatell JM; Gazzard BG; Hammer SM; Hirsch MS; Jacobsen DM; Katzenstein DA; Montaner JS; Richman DD; Saag MS; Schechter M; Schooley RT; Thompson MA; Vella S; Yeni PG; Volberding PA; Brown University School of Medicine, Providence, RI 02906, USA.; Charles_Carpenter@brown.edu; OBJECTIVE: To update recommendations for antiretroviral therapy for adult human immunodeficiency virus type 1 (HIV-1) infection, based on new information and drugs that are available. PARTICIPANTS: A 17-member international physician panel with antiretroviral research and HIV patient care experience initially convened
Nucleoside analogs plus ritonavir in stable antiretroviral therapy-experienced HIV-infected children: a randomized controlled trial. Pediatric AIDS Clinical Trials Group 338 Study Team.: JAMA. 2000 Jan 26;283(4):492-8. Unique Identifier : AIDSLINE MED/20123271; Nachman SA; Stanley K; Yogev R; Pelton S; Wiznia A; Lee S; Mofenson L; Fiscus S; Rathore M; Jimenez E; Borkowsky W; Pitt J; Smith ME; Wells B; McIntosh K; Department of Pediatrics, State University of New York at Stony; Brook, 11794-8111, USA. snachman@mail.som.sunysb.edu; CONTEXT: Although protease inhibitors are used routinely in adults with human immunodeficiency virus (HIV) infection, the role of these drugs in the treatment of clinically stable HIV-infected children is not clear. OBJECTIVE: To evaluate the safety, tolerance, and
Lamivudine for chronic hepatitis B: uses and abuses [editorial]: JPMA J Pak Med Assoc. 1999 Aug;49(8):183-4. Unique Identifier : AIDSLINE MED/20106254; Hamid S
[Nursing: profession with risk? (editorial)]: Med Clin (Barc). 1999 Nov 27;113(18):699-700. Unique Identifier : AIDSLINE MED/20116352; Campins Marti M
[Consensus document on tuberculosis prevention and control in Spain. Research Unit on Tuberculosis of Barcelona (UITB). Area of Tuberculosis and Respiratory Infections (TIR) of the Spanish Society of Pneumology and Thoracic Surgery (SEPAR) and Study Group on Aids (GESIDA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)]: Med Clin (Barc). 1999 Nov 27;113(18):710-5. Unique Identifier : AIDSLINE MED/20116355
[Reversibility of severe hyperlipemia secondary to indinavir with micronized phenofibrate (letter)]: Med Clin (Barc). 1999 Nov 27;113(18):716-7. Unique Identifier : AIDSLINE MED/20116357; de Luis DA; Aller R; Rachiller P; Ignacio Tortosa J
Millennium bugs. AIDS in Africa threatens the United States. It should not act accordingly.: Nature. 2000 Jan 13;403(6766):117. Unique Identifier : AIDSLINE MED/20133851
Wherever HIV originated, polio vaccine is safe now [letter]: Nature. 2000 Jan 13;403(6766):130. Unique Identifier : AIDSLINE MED/20110495; Wong KW
[Pulmonary infection from Rhodococcus equi after renal transplantation.Review of the literature]: Nephrologie. 1999;20(7):383-6. Unique Identifier : AIDSLINE MED/20107599; Gallen F; Kernaonet E; Foulet A; Goldstein A; Lebon P; Babinet F; Service de nephrologie-dialyse, Centre hospitalier general, Le; Mans.; Rhodococcus Equi, a strictly aerobic Gram positive coco-bacillus, is a pathogen for horses and foals. It may induce opportunistic infections and is described in AIDS infected patients. We report the case of a 47-year old man, breeder of horses, with kidney transplant who has presented, 8 years after his graft, an impa
Students' decisions to select HIV services for clinical experiences.: Nurse Educ. 1999 May-Jun;24(3):35-9. Unique Identifier : AIDSLINE MED/20104338; Patsdaughter CA; Grindel CG; O'Connor C; Miller KH; College of Nursing, Northeastern University, Boston,; Massachusetts, USA.; The ever-growing numbers of persons living with HIV/AIDS emphasizes the need for highly trained healthcare professionals to care for this population. Understanding why nursing and medical students would choose HIV services for clinical rotations, and the impact of those clinical experiences on their future professiona
Induction of cell-cycle arrest in cervical cancer cells by the human immunodeficiency virus type 1 viral protein R.: Unique Identifier : AIDSLINE MED/20100472; Toy EP; Rodriguez-Rodriguez L; McCance D; Ludlow J; Planelles V; OBJECTIVE: To determine the ability of the human immunodeficiency virus type 1 (HIV-1) gene vpr to induce cell-cycle arrest in cervical cancer cells with or without human papillomavirus (HPV) type 16 E6 or E7 expression. METHODS: High- and low-level expression vectors for vpr (designated pVPR(HIGH) and pVPR(LOW),
Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways.: Oncogene. 1999 Dec 23;18(56):7966-74. Unique Identifier : AIDSLINE MED/20105771; Na S; Li B; Grewal IS; Enslen H; Davis RJ; Hanke JH; Flavell RA; Section of Immunobiology, Yale University School of Medicine, New; Haven, Connecticut, CT 06520-8011, USA.; CDC42, a Ras-related small GTP binding protein, is involved in diverse cellular functions in lymphocytes. We generated transgenic mice expressing constitutively active murine CDC42 (Q61L) under the control of the human CD2 promoter. Transgenic mice showed smaller thymi with a dramatic reduction of CD4+CD8+, CD4+ and C
Infection of mice by a Toxoplasma gondii isolate from an AIDS patient: virulence and activation of hosts' immune responses are independent of parasite genotype.: Parasite Immunol. 1999 Dec;21(12):649-57. Unique Identifier : AIDSLINE MED/20050940; Haque S; Hanna S; Gharbi S; Franck J; Dumon H; Haque A; Department of Medicine and Microbiology, Dartmouth Medical School; Hanover, NH 03755, USA; Immunologie et Genetique Des Maladies; Parasitaires, INSERM U 399, Universite de Mediterranee Faculte; de Medecine, 13385 Marseille, France.; Virulence of a Toxoplasma gondii isolate from an AIDS patient (designated as PTN) was compared with that of PLK, a variant of P-strain. Virulence was assessed in term of host survival upon inoculation in different strains of mice. All C57BL/6 mice died of acute toxoplasmosis by 7-10 days following intraperitoneal infe
Epstein-Barr virus status and the histopathological changes of parotid gland lymphoid infiltrates in HIV-positive children.: Pathology. 1999 Nov;31(4):413-7. Unique Identifier : AIDSLINE MED/20107629; Chetty R; Vaithilingum M; Thejpal R; Department of Pathology, University of Natal School of Medicine,; Durban, South Africa. chettyr@med.und.ac.za; This study examined the EBV status and the morphology in parotid glands of a large cohort of HIV-positive pediatric patients. Nineteen children with vertically acquired HIV infection, ranging in age from three months to seven years and two months, were analyzed. Seventeen patients were assessed for serological evidenc
American Academy of Pediatrics. Committee on Infectious Diseases. Varicella vaccine update.: Pediatrics. 2000 Jan;105(1 Pt 1):136-41. Unique Identifier : AIDSLINE MED/20085270; Recommendations for routine varicella vaccination were published by the American Academy of Pediatrics in May 1995, but many eligible children remain unimmunized. This update provides additional information on the varicella disease burden before the availability of varicella vaccine, potential barriers to immunization
Atovaquone suspension in HIV-infected volunteers: pharmacokinetics, pharmacodynamics, and TMP-SMX interaction study.: Pharmacotherapy. 1999 Sep;19(9):1050-6. Unique Identifier : AIDSLINE MED/20076133; Falloon J; Sargent S; Piscitelli SC; Bechtel C; LaFon SW; Sadler B; Walker RE; Kovacs JA; Polis MA; Davey RT Jr; Lane HC; Masur H; National Institute of Allergy and Infectious Diseases and the; Warren G. Magnuson Clinical Center, National Institutes of; Health, Bethesda, Maryland 20892-1880, USA.; STUDY OBJECTIVE: To evaluate the pharmacokinetics and safety of atovaquone suspension in volunteers infected with the human immunodeficiency virus ((HIV). DESIGN: Open-label, nonrandomized study. SETTING: Two clinical research centers. PATIENTS: Twenty-two HIV-infected volunteers with a median CD4 cell count of 37 cel
HIV-associated lipodystrophy syndrome.: Pharmacotherapy. 2000 Jan;20(1):13-22. Unique Identifier : AIDSLINE MED/20104958; Qaqish RB; Fisher E; Rublein J; Wohl DA; Department of Pharmacy, University of North Carolina Hospitals; and Clinics, Chapel Hill, USA.; Highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1 (HIV-1) and prophylactic therapy for opportunistic infections have increased survival. Adverse effects of HAART include lipid profile alterations, diabetes mellitus, and fat redistribution. These metabolic and physical changes are called t
Decreased methadone effect after ritonavir initiation.: Unique Identifier : AIDSLINE MED/20104966; Geletko SM; Erickson AD; University of Rhode Island College of Pharmacy, Department of; Pharmacy Practice, Veterans Affairs Medical Center, Providence; 02908, USA.; Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial dr
Prevention of autoimmune diabetes by oral administration of syngeneic pancreatic extract to young NOD mice.: Pancreas. 2000 Jan;20(1):55-60. Unique Identifier : AIDSLINE MED/20094080; Reddy S; Stefanovic N; Karanam M; Department of Paediatrics, University of Auckland School of; Medicine, New Zealand. s.reddy@auckland.ac.nz; Oral administration of relevant autoantigens is being considered as a realistic approach for the prevention of several autoimmune diseases. In this study we administered, orally, to young female NOD/Ak mice (diabetes incidence, 40%) and NOD/LtJ mice (diabetes incidence, 70%) whole pancreatic extract on days 19, 20, 21
A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.: Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):279-84. Unique Identifier : AIDSLINE MED/20087240; Herrera PL; Harlan DM; Vassalli P; Department of Morphology, University of Geneva Medical School, 1; rue Michel-Servet, 1211 Geneva 4, Switzerland.; Pedro.Herrera@medecine.unige.ch; Double transgenic mice [rat insulin promoter (RIP)-tumor necrosis factor (TNF) and RIP-CD80] whose pancreatic beta cells release TNF and bear CD80 all develop an acute early (6 wk) and lethal diabetes mediated by CD8 T cells. The first ultrastructural changes observed in beta cells, so far unreported, are focal lesion
Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model.: Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):297-302. Unique Identifier : AIDSLINE MED/20087243; Arichi T; Saito T; Major ME; Belyakov IM; Shirai M; Engelhard VH; Feinstone SM; Berzofsky JA; Molecular Immunogenetics, Metabolism Branch, National Cancer; Institute, National Institutes of Health, Bethesda, MD 20892,; USA.; DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a small-animal model using HLA-A2.1-transgenic mice to test induction of HLA-A2.1-restricted cytotoxic T lymphocytes (CTLs
The long cytoplasmic tail of gp41 is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation into virions.: Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):343-8. Unique Identifier : AIDSLINE MED/20087251; Murakami T; Freed EO; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892-0460, USA.; Lentiviruses, including HIV-1, have transmembrane envelope (Env) glycoproteins with cytoplasmic tails that are quite long compared with those of other retroviruses. However, mainly because of the lack of biochemical studies performed in cell types that are targets for HIV-1 infection, no clear consensus exists regardi
The Nef protein of HIV-1 associates with rafts and primes T cells for activation.: Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):394-9. Unique Identifier : AIDSLINE MED/20087260; Wang JK; Kiyokawa E; Verdin E; Trono D; Department of Genetics and Microbiology, University of Geneva,; CH-1211 Geneva, Switzerland.; The Nef protein is an important virulence factor of primate lentiviruses, yet the mechanisms by which it exerts this influence are imperfectly understood. Here, using an inducible system, we demonstrate that Nef increases IL-2 secretion from T cells stimulated via CD3
Q beta bacteriophage photoinactivated by methylene blue plus light involves inactivation of its genomic RNA.: Photochem Photobiol. 1999 Dec;70(6):902-9. Unique Identifier : AIDSLINE MED/20093788; Schneider JE Jr; Pye Q; Floyd RA; Free Radical Biology & Aging Research Program, Oklahoma Medical; Research Foundation, Oklahoma City 73104, USA.; Ed-Schneider@omrf.ouhsc.edu; Methylene blue (MB) is being used as a sensitizer for the photodynamic inactivation of viral contaminants, including the human immunodeficiency virus, in blood and blood components used in medical treatment. We recently showed that oxygen-dependent photodynamic inactivation of the RNA bacteriophage Q beta with MB plus
Perceived importance of services for persons with AIDS: recipient, family, caregiver, and public differences.: Psychol Rep. 1999 Oct;85(2):463-70. Unique Identifier : AIDSLINE MED/20077901; McNeill KF; Kposowa A; Department of Sociology, University of California, Riverside; 92521, USA. kevin-mcneill@worldnet.att.net; 596 adults from a moderately sized community in central California were divided into four groups (person with HIV or AIDS, friend or relative, caregiver or service provider for such a person, or member of the general public) and completed a schedule assessing their perceptions of the importance of 36 items related to
Genetically identical primate modelling systems for HIV vaccines.: Reprod Fertil Dev. 1998;10(7-8):651-7. Unique Identifier : AIDSLINE MED/20077719; Kent SJ; Lewis IM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; kent@burnet.edu.au; There is an urgent need for a safe and effective vaccine to prevent human immunodeficiency virus (HIV) infection. Several HIV vaccine candidates have shown promise, but many concerns regarding the safety and efficacy of current vaccines remain. A major hindrance in HIV vaccine development is a poor understanding of pr
Experiences of the Dresdner Cord Blood Bank, supported by the Deutsche Knochenmarkspenderdatei.: Semin Thromb Hemost. 1999;25(6):575-8. Unique Identifier : AIDSLINE MED/20096342; Ordemann R; Petzold K; Holig K; Schaffer B; Mauersberger S; Ehminger G; Department of Medicine I, University Hospital Dresden, Germany.; Allogeneic bone marrow and peripheral blood stem cell transplantation is the treatment of choice for some malignant hematologic diseases, marrow failure syndromes, and severe congenital immunodeficiency states. Since Gluckman et al reported in 1988 the first successful human leukocyte antigen (HLA)-matched sibling umb
The intersections of HIV and violence: directions for future research and interventions.: Soc Sci Med. 2000 Feb;50(4):459-78. Unique Identifier : AIDSLINE MED/20104766; Maman S; Campbell J; Sweat MD; Gielen AC; Department of International Health, School of Hygiene and Public; Health, Johns Hopkins University, Baltimore, MD 21205, USA.; smaman@jhsph.edu; The purpose of this paper is to review the available literature on the intersections between HIV and violence and present an agenda for future research to guide policy and programs. This paper aims to answer four questions: (1) How does forced sex affect women s risk for HIV infection? (2) How do violence and threats
Selling sex in the time of AIDS: the psycho-social context of condom use by sex workers on a Southern African mine.: Unique Identifier : AIDSLINE MED/20104767 P
Rural acquired immunodeficiency syndrome in low and high prevalence areas.: South Med J. 2000 Jan;93(1):36-43. Unique Identifier : AIDSLINE MED/20116764; Berry DE; Health Care Administration Program, Macon State College, GA; 31206-5144, USA.; BACKGROUND: Too little is understood about the spread of the acquired immunodeficiency syndrome (AIDS) in rural America. This study focuses on changes over 5 years in two low prevalence and two high prevalence human immunodeficiency virus (HIV) rural service areas. METHODS: An initial study conducted in 1993 provided
Immunization status of children born to human immunodeficiency virus (HIV)-infected mothers in two Texas cities.: South Med J. 2000 Jan;93(1):48-52. Unique Identifier : AIDSLINE MED/20116766; Schulte JM; Burkham S; Squires JE; Doran T; Hamaker DW; Pelosi J; Graper J; Davis R; Caldwell MB; Texas Department of Health, Austin, USA.; BACKGROUND: Because HIV-infected and HIV-exposed children are at risk of acquiring infectious diseases, they should be immunized. METHODS: We abstracted charts at pediatric HIV clinics in Dallas and San Antonio, matched the children to birth certificates and assessed up-to-date immunization status. RESULTS: Of the 178
Rapid onset of stupor.: South Med J. 2000 Jan;93(1):70-1. Unique Identifier : AIDSLINE MED/20116772; Brough AS; Stewart F; Zackowski S; Department of Psychiatry, Naval Medical Center, Portsmouth, VA,; USA.; Catatonia is a syndrome with many causes that can be difficult to diagnose. In this report, we describe a case of rapid onset of stupor and loss of consciousness, subsequent evaluation, and treatment of catatonia in an HIV-positive man.
Sustainable HIV/AIDS managed care a reality [news]: S Afr Med J. 1999 Nov;89(11):1140. Unique Identifier : AIDSLINE MED/20067389
Following the HIV-1 trail--from source to South Africa.: S Afr Med J. 1999 Nov;89(11):1146. Unique Identifier : AIDSLINE MED/20067392; Wood R; Department of Medicine, University of Cape Town.
AIDS education initiative [editorial]: S Afr Med J. 1999 Nov;89(11):1159-60. Unique Identifier : AIDSLINE MED/20067398; Martin D; Ncayiyana D
Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-xenopus (FETAX): biotransformation and detoxification.: Unique Identifier : AIDSLINE MED/20075170 P; Fort DJ
Immune response to blood transfusion invery-low-birthweight infants.: Transfusion. 2000 Jan;40(1):25-34. Unique Identifier : AIDSLINE MED/20113052; Wang-Rodriguez J; Fry E; Fiebig E; Lee T; Busch M; Mannino F; Lane TA; University of California, San Diego, Medical Center, Hillcrest,; San Diego, California, USA. jwrodriguez@ucsd.edu; BACKGROUND: Allogeneic blood transfusion is common in the treatment of neonatal anemia of prematurity or anemia due to multiple phlebotomies. The immune response of neonates to passenger leukocytes from allogeneic red cells was investigated. STUDY DESIGN AND METHODS: Fourteen infants (4 male, 10 female) prospectively
Viral safety of solvent/detergent-treated plasma.: Transfusion. 2000 Jan;40(1):84-90. Unique Identifier : AIDSLINE MED/20113061; Solheim BG; Rollag H; Svennevig JL; Arafa O; Fosse E; Bergerud U; Institute of Immunology, Rikshospitalet, The National Hospital,; University of Oslo, Norway. b.g.solheim@rh.uio.no; BACKGROUND: Pooling of plasma donations increases the risk for blood-borne infections. In solvent/detergent (SD)-treated plasma, lipid-enveloped viruses are efficiently inactivated. This method, however, does not affect non-lipid-enveloped viruses. The current study investigated the viral safety of SD-treated plasma (
[Thalidomide--failure or success? A controversial drug during the last fifty years--the pendulum swings--a renaissance for thalidomide?]: Ugeskr Laeger. 2000 Jan 3;162(1):52-3. Unique Identifier : AIDSLINE MED/20122959; Dalhoff KP; Poulsen HE
Detection of bovine immunodeficiency virus DNA in the blood and semen of experimentally infected bulls.: Vet Microbiol. 1999 Oct;70(1-2):21-31. Unique Identifier : AIDSLINE MED/20057494; Gradil CM; Watson RE; Renshaw RW; Gilbert RO; Dubovi EJ; Department of Population Medicine and Diagnostic Sciences,; College of Veterinary Medicine, Cornell University, Ithaca, NY; 14850, USA.; Five 18- to 24-month-old bulls were inoculated with either a cell suspension containing bovine immunodeficiency virus (BIV-FL112; 3 bulls) or a BIV-free cell suspension (2 bulls). Blood and semen specimens were collected once a week for 14 weeks, and seroconversion was confirmed by indirect immunofluorescent antibody
[New aspects of the pathogenesis of HIV infections]: Zentralbl Gynakol. 1999;121(11):543-5. Unique Identifier : AIDSLINE MED/20078347; Rubbert A; Klinik I fur Innere Medizin, Universitat Koln.
[Current therapeutic protocols and efficacy of new antiretroviral drugs for the treatment of HIV infection taking into consideration gender-specific profile of side effects]: Zentralbl Gynakol. 1999;121(11):545-9. Unique Identifier : AIDSLINE MED/20078348; Rockstroh J; Medizinische Universitatsklinik I, Bonn. rockstroh@uni-bonn.de
[Prenatal care of a HIV-1-positive pregnancy and birth]: Zentralbl Gynakol. 1999;121(11):549-52. Unique Identifier : AIDSLINE MED/20078349; Beichert M; Buchholz B; Weigel M; Martini M; Breitkreutz R; Melchert F; Universitatsfrauenklinik, Mannheim.; matthias.beichert@gyn.ma.uni-heidelberg.de; Mother-to-child (vertical) transmission of the human immunodeficiency virus type-1 (HIV-1) is now the main route of infection in HIV-positive children. Without any medical measures and avoiding breastfeeding the rate of vertical HIV-1-transmission is 15-20% in Europe. The rate of vertical HIV-transmission in the Germa
[Effects of high grade antiretroviral therapy on body fat distribution and metabolism]: Zentralbl Gynakol. 1999;121(11):552-3. Unique Identifier : AIDSLINE MED/20078350; Schwenk A; Department of Infectious Disease St. George's Hospital.; a.schwenk@sghms.ac.uk
[Psychosocial aspects of life style for women with HIV and AIDS with special consideration of sexuality and desire of children]: Zentralbl Gynakol. 1999;121(11):553-5. Unique Identifier : AIDSLINE MED/20078351; Spreu K
[Special problems of HIV-positive women who are either drug abusers or on methadone replacement therapy]: Zentralbl Gynakol. 1999;121(11):555-7. Unique Identifier : AIDSLINE MED/20078352; Isernhagen K
Synthesis of 1-amino-2-(4-chloro-2-mercaptobenzenesulfonyl)guanidine derivatives with potential pharmacological activity.: Acta Pol Pharm. 1999 Mar-Apr;56(2):143-53. Unique Identifier : AIDSLINE MED/20101275; Pomarnacka E; Kornicka A; Department of Chemical Technology of Drugs, Medical University of; Gdansk, Poland.; Syntheses of 1-amino-3-R2-2-(4-chloro-2- mercaptobenzenesulfonyl)guanidines [Va-o], 1-benzylidencimino-3-R2-2-(4-chloro-2- mercaptobenzenesulfonyl)guanidines [X, XII-XIX] and N-(4-chlorobenzylidene)-N -(6-chloro-7-methyl-l, 1-dioxo- 1,4,2-benzodithiazin-3-yl)hydrazine [XX] have been described. The moderate anticancer
Chemokines and their receptors in lymphocyte traffic and HIV infection.: Adv Immunol. 2000;74:127-80. Unique Identifier : AIDSLINE MED/20073539; Loetscher P; Moser B; Baggiolini M; Theodor Kocher Institute, University of Bern, Switzerland.
Increased frequency of interferon-gamma-producing peripheral blood CD4+ T cells in chronic hepatitis C virus infection.: Am J Gastroenterol. 2000 Jan;95(1):227-32. Unique Identifier : AIDSLINE MED/20102127; Kawakami Y; Nabeshima S; Furusyo N; Sawayama Y; Hayashi J; Kashiwagi S; Department of General Medicine, Kyushu University Hospital,; Fukuoka, Japan.; OBJECTIVES: To determine the profile of cytokine secretion by CD4+ T helper (Th) cells in chronic hepatitis C virus (HCV) infection, we used flow cytometry to determine the percentage of interferon (IFN)-gamma and interleukin (IL)-4 producing cells from CD4+ T lymphocytes in peripheral blood obtained from patients chr
Intestinal pseudo-obstruction and acute pandysautonomia associated with Epstein-Barr virus infection.: Am J Gastroenterol. 2000 Jan;95(1):280-4. Unique Identifier : AIDSLINE MED/20102136; Besnard M; Faure C; Fromont-Hankard G; Ansart-Pirenne H; Peuchmaur M; Cezard JP; Navarro J; Department of Pediatric Gastroenterology, Hopital Robert Debre,; Paris, France.; We report the association of neurological and intestinal disorders with the reactivation of Epstein-Barr virus (EBV) in a child. This previously healthy 13-yr-old boy presented with pharyngitis and acute abdominal ileus. Laparotomy excluded a mechanical obstruction. Postoperatively, he suffered from prolonged intestin
Cytomegalovirus infection in AIDS presenting as a rectal mass [letter]: Am J Gastroenterol. 2000 Jan;95(1):327-8. Unique Identifier : AIDSLINE MED/20102162; Goyal RS; Goyal SB
Natural history of hepatitis C.: Am J Med. 1999 Dec 27;107(6B):10S-15S. Unique Identifier : AIDSLINE MED/20117174; Seeff LB; National Institutes of Health/NIDDK, Bethesda, Maryland 20892,; USA.; It is now widely accepted that 85% or more of individuals with acute hepatitis C virus (HCV) infection progress to chronic hepatitis, and chronic hepatitis C is a known risk factor for cirrhosis and hepatocellular carcinoma (HCC). However, there has been much controversy about the inevitability of developing cirrhosis
Analogy of human immunodeficiency virus to hepatitis C virus: the human immunodeficiency model.: Am J Med. 1999 Dec 27;107(6B):41S-44S. Unique Identifier : AIDSLINE MED/20117180; Pollard RB; Department of Internal Medicine, University of Texas Medical; Branch, Galveston 77555, USA.; The human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) for many years overshadowed hepatitis C, which we now know is in some ways an even bigger problem. Important differences also exist between these two viruses and the diseases they cause, and we must be cautious about drawing too close
Viral kinetics and mathematical models.: Am J Med. 1999 Dec 27;107(6B):49S-52S. Unique Identifier : AIDSLINE MED/20117182; Perelson AS; Theoretical Biology and Biophysics, Los Alamos National; Laboratory, New Mexico 87544, USA.; Mathematical models can provide insights into the dynamics of viral diseases. Methods that were introduced to analyze human immunodeficiency virus dynamics in vivo can be modified to give insights into hepatitis C virus (HCV) dynamics, the mechanisms of action of interferon, and the consequences of giving different do
Chronic hepatitis C viral infection in patients with normal serum alanine aminotransferases.: Am J Med. 1999 Dec 27;107(6B):53S-55S. Unique Identifier : AIDSLINE MED/20117183; Di Bisceglie AM; Department of Internal Medicine, Saint Louis University School of; Medicine, Missouri 63104, USA.; A substantial proportion of patients with chronic hepatitis C virus (HCV) infection (HCV RNA positive) have persistently normal serum alanine aminotransferases (ALT). These patients currently pose a therapeutic dilemma, as it is not clear how best to deal with them. Response rates to interferon are low, and in some ca
Management of interferon relapsers.: Am J Med. 1999 Dec 27;107(6B):62S-66S. Unique Identifier : AIDSLINE MED/20117185; Jacobson I; Division of GI and Hepatology, Weill Medical College of Cornell; University, New York Presbyterian Hospital, New York 10021, USA.; Relapse in patients who have evidenced an initial response to a course of interferon monotherapy for chronic hepatitis C virus (HCV) infection has been a major frustration. At least 70% of responders will relapse after a 6-month course of treatment and more than 50% will relapse after a 12-month course of treatment, u
Principles of interferon induction therapy.: Am J Med. 1999 Dec 27;107(6B):71S-73S. Unique Identifier : AIDSLINE MED/20117187; Layden TJ; Department of Medicine, University of Illinois at Chicago Medical; Center, 60612, USA.; Several strategies have been devised to enhance the number of patients with hepatitis C virus (HCV) infection who achieve a sustained response to interferon-alpha therapy. Induction therapy uses higher than usual doses of interferon, given on a daily, rather than three times per week basis, for a defined period. The g
Hepatitis C virus and human immunodeficiency virus: clinical issues in coinfection.: Am J Med. 1999 Dec 27;107(6B):79S-84S. Unique Identifier : AIDSLINE MED/20117189; Dieterich DT; Department of Medicine, New York University School of Medicine,; New York 10016, USA.; The prevalence of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection ranges from nearly 30% to over 50%, depending on the population. Shared modes of transmission and the success of current antiretroviral regimens have contributed to the emergence of HCV as a significant pathogen in the HIV-pos
Management of hepatitis C in the hemophilia patient.: Am J Med. 1999 Dec 27;107(6B):85S-89S. Unique Identifier : AIDSLINE MED/20117190; Fried MW; Department of Medicine, Clinical Hepatology, University of North; Carolina at Chapel Hill, 27599-7080, USA.; Patients with hemophilia who received clotting factor concentrates before the availability of heat-treated factors in the mid-1980s were almost universally infected with hepatitis C virus (HCV). Until recently, the clinical impact of chronic hepatitis C was largely overshadowed by human immunodeficiency virus (HIV) in
Gammaherpesviruses and "Hit-and-Run" oncogenesis.: Am J Pathol. 2000 Jan;156(1):1-3. Unique Identifier : AIDSLINE MED/20090541; Ambinder RF; Departments of Oncology, Pathology, and Pharmacology, The Johns; Hopkins School of Medicine and Oncology Center, Baltimore,; Maryland 21231, USA. rambind@jhmi.edu
Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals.: Am J Pathol. 2000 Jan;156(1):151-8. Unique Identifier : AIDSLINE MED/20090558; Sauer H; Gunther J; Hescheler J; Wartenberg M; Department of Neurophysiology, University of Cologne, Cologne,; Germany.; Thalidomide is a teratogen with anti-angiogenic properties and causes stunted limb growth (dysmelia) during human embryogenesis. The molecular mechanisms of thalidomide action in embryopathy are currently unknown. Using the endothelial-specific antigen platelet endothelial cell adhesion molecule-1 and confocal laser s
HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms.: Unique Identifier : AIDSLINE MED/20088632; Cai R; Carpick B; Chun RF; Jeang KT; Williams BR; Lerner Research Institute, Cleveland Clinic Foundation, 9500; Euclid Avenue, Cleveland, Ohio 44195, USA.; Replication of the human immunodeficiency virus type 1 (HIV-1) is inhibited by interferons (IFNs), in part through activity of the IFN-inducible protein kinase PKR. To escape this antiviral effect, HIV-1 has developed strategies for blocking PKR function. We have previously shown that the HIV-1 Tat protein can associa
Treatment of human immunodeficiency virus enteropathy with a gluten-free diet [letter]: Arch Intern Med. 2000 Jan 24;160(2):244. Unique Identifier : AIDSLINE MED/20112294; Nellen H; Flores G; Wacher N
Tat mediates apoptosis in vivo in the rat central nervous system.: Biochem Biophys Res Commun. 2000 Jan 7;267(1):252-6. Unique Identifier : AIDSLINE MED/20090624; Gavriil ES; Cooney R; Weeks BS; Department of Biology, Adelphi University, Garden City, New York,; 11530, USA.; The HIV-1 transactivator of transcription, Tat, mediates apoptosis in neurons and may cause AIDS-associated neurologic disorders, which include dementia and loss of motor control. Here we investigate the ability of Tat to stimulate apoptosis in the rat central nervous system in viv
[Conjugates of 2',3'-didehydro-3'-deoxythymidine with thymogen. Synthesis and anti-HIV activity]: Bioorg Khim. 1999 Jul;25(7):499-504. Unique Identifier : AIDSLINE MED/20028942; Riakhovskii VV; Malekin SI; Nosova VM; Kisin AV; Krugliak IuL; Kurochkin VK; State Research Institute of Organic Chemistry and Technology,; Moscow, Russia.; An effective synthesis of thymogen was developed. Conjugates of 2 ,3 -didehydro-3 -deoxythymidine (nucleoside d4T ) with thymogen were prepared in which the nucleoside hydroxyl group was linked to the thymogen carboxyl group of either tryprophan or glu
[Synthesis and biological activity of anomeric muramoyldipeptide butylglycosides]: Bioorg Khim. 1999 Sep;25(9):708-15. Unique Identifier : AIDSLINE MED/20089688; Pertel' SS; Kadun AL; Kakaian ES; Chirva VIa; Krivorutchenko IuL; Krivoshein IuS; Bakova AA; Andronovskaia IB; Frunze State University, Simferopol, Ukraine.; orgchem@ccssu.crimea.ua; The synthesis of anomeric butyl glycosides of muramyl dipeptide was reported. alpha-Butyl glycoside of N-acetyl-D-glucosamine was 4,6-O-benzylidenated and the benzylidene derivative was 3-O-alkylated by the Williamson reaction with sodium (S)-2-chloropropionate. The resulting protected alpha-butyl glycoside of muramic
Stochastic properties of one-parameter discrete model of genetic diversity in the unique random parameter case.: J Biomol Struct Dyn. 1999 Dec;17(3):597-605. Unique Identifier : AIDSLINE MED/20100048; Shchelkanov MY; Soinov LA; Yudin AN; Denisov MV; Slavsky AA; Petrenko MS; Vedenov AA; Moscow Institute of Physics and Technology, Faculty of Molecular; and Biological Physics, Department of Molecular Biophysics,; Dolgoprudny, Russia.; Stochastic properties of previously introduced one parameter discrete model of genetic diversity (M. Yu. Shchelkanov et al, J. Biomol. Struct. Dyn. 15, 887-894 (1998)) are investigated. Two approaches are compared: (A) when the on-step substitution number and/or the number of substitution steps are random variables; (
Early immune response in susceptible and resistant mice strains with chronic Pseudomonas aeruginosa lung infection determines the type of T-helper cell response.: APMIS. 1999 Dec;107(12):1093-100. Unique Identifier : AIDSLINE MED/20123535; Moser C; Hougen HP; Song Z; Rygaard J; Kharazmi A; Hoiby N; Department of Clinical Microbiology, Rigshospitalet, Copenhagen; Denmark.; Most cystic fibrosis (CF) patients become chronically infected with Pseudomonas aeruginosa in the lungs. The infection is characterized by a pronounced antibody response and a persistant inflammation dominated by polymorphonuclear neutrophils. Moreover a high antibody response correlates with a poor prognosis. We spec
Cloning trap for signal peptide sequences.: Biotechniques. 2000 Jan;28(1):124-6, 128-30. Unique Identifier : AIDSLINE MED/20114042; Lim SP; Garzino-Demo A; Institute of Molecular and Cell Biology, Singapore.; mcblimsp@mcbsgs1.imcb.nus.edu.sg; Novel secreted and/or type I transmembrane proteins containing N-terminal signal sequences have been successfully cloned using the signal sequence trapping (SST) method. Often this involves random cloning of short 5 cDNA terminal ends into an epitope-tagged expression vector and the detection of expressed recombinant
Alterations in head and neck cancer occurring in HIV-infected patients--results of a pilot, longitudinal, prospective study.: Acta Oncol. 1999;38(8):1047-50. Unique Identifier : AIDSLINE MED/20127527; Singh B; Sabin S; Rofim O; Shaha A; Har-El G; Lucente FE; Department of Otolaryngology, State University of New York-Health; Science Center at Brooklyn, USA. bsinghmd@hotmail.com; To assess the impact of human immunodeficiency virus (HIV) infection on the presentation and course of head and neck squamous cell carcinoma (HNSCC), we performed a pilot, prospective, longitudinal study of all patients with HNSCC presenting to our institutions over a 6-month period (n = 10). A 60% incidence of HIV in
Cost-effectiveness analysis of pegylated-liposomal doxorubicin and liposomal daunorubicin treatments in patients with Kaposi's sarcoma.: Acta Oncol. 1999;38(8):1063-7. Unique Identifier : AIDSLINE MED/20127530; Hjortsberg C; Persson U; Lidbrink E; Bennett C; Swedish Institute for Health Economics, Lund. ch@ihe.se; Economic evaluations of new AIDS treatment drugs are important. For physicians treating patients with Kaposi s sarcoma, these issues are especially meaningful since cancer treatment costs for this group of patients are high. Kaposi s sarcoma is the most frequently occurring neoplasm in AIDS patients, affecting about 1
Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):1-3. Unique Identifier : AIDSLINE MED/20092432; Loeb LA; Mullins JI; Department of Pathology, University of Washington, Seattle; 98195-7705, USA. laloeb@u.washington.edu; The extraordinarily high mutation rate of HIV suggests that the viral population exists near the threshold for viral viability. An increase in mutation could mediate a lethal increase in the already high proportion of defective viruses. We initially tested this hypothesis by culturing HIV-infected cells in mutagenic d
Influenza virus upregulates CXCR4 expression in CD4+ cells.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):19-25. Unique Identifier : AIDSLINE MED/20092435; Puri A; Riley JL; Kim D; Ritchey DW; Hug P; Jernigan K; Rose P; Blumenthal R; Carroll RG; Laboratory of Experimental and Computational Biology, NCI-FCRDC,; Frederick, Maryland 21702, USA. apuri@helix.nih.gov; We examined the effect of prior influenza virus infection on the susceptibility of CD4+ cells to HIV-1 infection. Influenza virus infection of HeLa-CD4 cells resulted in a marked increase in susceptibility to infection by CXCR4-dependent but not CCR5-dependent HIV isolates. Influenza virus infection resulted in an inc
Cell-dependent mechanisms restrict the HIV type 1 coreceptor activity of US28, a chemokine receptor homolog encoded by human cytomegalovirus.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):27-35. Unique Identifier : AIDSLINE MED/20092436; Ohagen A; Li L; Rosenzweig A; Gabuzda D; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.; Several members of the chemokine receptor family are used together with CD4 for HIV-1 entry into target cells. The human cytomegalovirus US28 gene encodes a chemokine receptor homolog that has been reported to function as an HIV-1 coreceptor. However, studies of US28 have given con
Deletion of the GPG motif in the HIV type 1 V3 loop does not abrogate infection in all cells.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):37-48. Unique Identifier : AIDSLINE MED/20092437; Su J; Palm A; Wu Y; Sandin S; Hoglund S; Vahlne A; Division of Clinical Virology, Karolinska Institutet, Huddinge; University Hospital, Huddinge/Stockholm, Sweden.; The three amino acids glycine, proline, and glycine (GPG) constitute a conserved motif at the center of the V3 loop of HIV-1 surface glycoprotein 120. It has been indicated that deletion of this GPG motif is lethal for viral infectivity and abrogates the ability of the virus to form syncytia. In the present work, we s
Intersubtype recombinant HIV type 1 involving HIV-MAL-like and subtype H-like sequence in four Norwegian cases.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):49-58. Unique Identifier : AIDSLINE GENBANK/AJ237579; Jonassen TO; Grinde B; Asjo B; Hasle G; Hungnes O; Department of Virology, National Institute of Public Health,; Oslo, Norway.; Suspected epidemiological links between three cases of human immunodeficiency virus type 1 (HIV-1) infection were verified by the finding of a shared unique virus genotype. A probable male index case was not available for testing. Case 1 was a female sexual partner of the index case. Case 2 was an adult son of case 1.
Origin of HIV type 1 in colonial French Equatorial Africa?: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):5-8. Unique Identifier : AIDSLINE MED/20092433; Chitnis A; Rawls D; Moore J; Department of Anthropology, University of California, San Diego; 92093, USA.; Sociocultural factors during the postcolonial period have been implicated as paramount in generating conditions that promoted both the origin and subsequent epidemic spread of HIV-1 in Africa. We suggest, however, that the origin of the disease may lie in the interaction between colonial practices (e.g., labor camps,
A retro-inverso miniantibody with anti-HIV activity.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):59-65. Unique Identifier : AIDSLINE MED/20092439; Levi M; Hinkula J; Wahren B; Department of Virology, Swedish Institute for Infectious Disease; Control and Karolinska Institute, Solna. michael.levi@smi.ki.se; An HIV-1-specific miniantibody, a peptide representing the third heavy chain complementarity-determining region (CDR) of an HIV-specific mouse antibody, was characterized and modified with unnatural D-isomeric amino acids. The CDR peptide and its parent antibody bound to a similar epitope, located in the V3 region of
Identification of subdominant cytotoxic T lymphocyte epitopes encoded by autologous HIV type 1 sequences, using dendritic cell stimulation and computer-driven algorithm.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):67-76. Unique Identifier : AIDSLINE MED/20092440; Jin X; Roberts CG; Nixon DF; Safrit JT; Zhang LQ; Huang YX; Bhardwaj N; Jesdale B; DeGroot AS; Koup RA; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, New York 10016, USA. xjin@adarc.org; Conventional analysis of the cytotoxic T lymphocyte (CTL) response to HIV-1 may underestimate the true breadth of CTL epitopes recognized. This underestimation could be due to several reasons, including (1) the use of laboratory-adapted stains of HIV or consensus sequences, which would lead to the identification of on
Idiotype cascades associated with the CD4-HIV glycoprotein 120 interaction: immunization with anti-idiotypic antibodies induces anti-anti-idiotypic responses with anti-CD4 specificity and in vitro neutralizing activity.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):77-86. Unique Identifier : AIDSLINE MED/20092441; Shearer MH; Dalgleish AG; Chanh TC; Kennedy RC; Department of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City 73104, USA.; Anti-idiotypic antibodies (Ab-2), which were generated in baboons against a mouse monoclonal antibody specific for the CD4 molecule expressed on human T cells, were used to produce anti-anti-idiotypic antibodies (Ab-3) in mice. This response induced by Ab-2 immunization of BALB/c mice was classified as anti-anti-idiot
Frequency of the CCR5delta32 allele in the Moroccan population [letter]: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):87-9. Unique Identifier : AIDSLINE MED/20092442; Elharti E; Elaouad R; Simons MJ; Messouak-Elhachimi Z; Gluckman JC; Parmentier M; Benjouad A
Role of apoptosis induction in both peripheral lymph nodes and thymus in progressive loss of CD4+ cells in SHIV-infected macaques.: AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):9-18. Unique Identifier : AIDSLINE MED/20092434; Iida T; Ichimura H; Shimada T; Ibuki K; Ui M; Tamaru K; Kuwata T; Yonehara S; Imanishi J; Hayami M; Department of Microbiology, Kyoto Prefectural University of; Medicine, Japan. iida@basic.kpu-m.ac.jp; To investigate the role of apoptosis in the progressive loss of CD4+ lymphocytes in HIV infection, we have used macaques infected with SHIV, a hybrid virus of HIV and simian immunodeficiency virus (SIV). In the present study, we sequentially analyzed apoptosis induction in the acute phase of SHIV infection. Four macaq
Cocaine abuse sharply reduced in an effective methadone maintenance program.: J Addict Dis. 1999;18(4):63-75. Unique Identifier : AIDSLINE MED/20095825; Borg L; Broe DM; Ho A; Kreek MJ; Rockefeller University, The Laboratory of the Biology of; Addictive Diseases, New York, NY 10021, USA.; borgl@rockvax.rockefeller.edu; A comprehensive study of an urban methadone clinic with supervised urine analyses for illicit drugs was conducted over an 18 month period for a 133 patient cohort as they entered or remained in methadone maintenance for narcotic addiction. Overall retention during the study was 85%, with significantly (p
Seroprevalence of hepatitis C in a sample of middle class substance abusers.: J Addict Dis. 1999;18(4):77-87. Unique Identifier : AIDSLINE MED/20095826; Abraham HD; Degli-Esposti S; Marino L; Department of Psychiatry at the Mount Auburn Hospital, Cambridge,; MA 02238, USA. abraham@grapevine2.com; Hepatitis C (HCV) is an indolent and often fatal disease affecting four million Americans commonly associated with low socioeconomic status. We assessed its prevalence in a sample of 334 consecutively admitted middle class substance abusers in a private urban hospital, and ascertained risk factors for its transmission
Gene transfer to liver cancer cells of B7-1 plus interleukin 12 changes immunoeffector mechanisms and suppresses helper T cell type 1 cytokine production induced by interleukin 12 alone.: Unique Identifier : AIDSLINE MED/20110565; Sun Y; Qian C; Peng D; Prieto J; Department of Internal Medicine, School of Medicine, University; of Navarra, Pamplona, Spain.; To investigate the cooperative effect of B7-1 and IL-12 in the induction of antitumor activity, we have developed retroviral vectors encoding human B7-1, murine IL-12, or both B7-1 and IL-12 coordinately. Murine transformed liver cells (BNL) were engineered to stably express B7-1, IL-12, or both by infection with corr
A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus-pseudotyped retroviral vector.: Hum Gene Ther. 2000 Jan 1;11(1):91-100. Unique Identifier : AIDSLINE MED/20110562; Demaison C; Brouns G; Blundell MP; Goldman JP; Levinsky RJ; Grez M; Kinnon C; Thrasher AJ; Molecular Immunology Unit, Institute of Child Health, London,; United Kingdom.; We have investigated the minimal time required for efficient transduction of human hematopoietic repopulating cells using a surrogate nonobese diabetic (NOD)/severe combined immunodeficient (SCID) xenoengraftment assay. Cord blood CD34+ cells were transduced to high levels over 24-48 hr in the presence of Flt-3 ligand
Preparation and in vivo testing of porous alumina ceramics for cell carrier applications.: Biomaterials. 2000 Jan;21(1):63-9. Unique Identifier : AIDSLINE MED/20084697; Eckert KL; Mathey M; Mayer J; Homberger FR; Thomann PE; Groscurth P; Wintermantel E; Department of Materials, ETH Zurich, Schlieren, Switzerland.; eckert@biocomp.mat.ethz.ch; Microporous alumina was used to develop implantable cell carriers shaped as a hollow-sphere with a central opening to allow ingrowth of vascularised tissues. The carriers were produced by suspending the ceramic raw materials in water, homogenising and dropping the resulting slurry onto a heated plate (hot plate mouldi
[The recognition of AIDS as a disabling pathology among the members of the Special Regime of the Sea in the province of Cadiz]: Aten Primaria. 1999 Dec;24(10):579-83. Unique Identifier : AIDSLINE MED/20124683; Abellan Hervas MJ; Esteban Lopez S; Foneubierta Fernandez A; Lazuen Alcon A; Escuela Universitaria de Ciencias de la Salud, Cadiz.; OBJECTIVES: To identify the year in which AIDS appeared as a cause of permanent disability among the members of the Special Sea Regime (REM), and to evaluate the clinical, social and labour characteristics of AIDS patients between 1987 and 1996. DESIGN: Descriptive study of series of cases. SETTING: Cadiz Province, 19
Atomic force microscopy and electron microscopy analysis of retrovirus Gag proteins assembled in vitro on lipid bilayers.: Biophys J. 2000 Jan;78(1):373-84. Unique Identifier : AIDSLINE MED/20086623; Zuber G; Barklis E; Vollum Institute, Department of Microbiology, Oregon Health; Sciences University, Portland, Oregon 97201-3098 USA.; We have used an in vitro system that mimics the assembly of immature Moloney murine leukemia virus (M-MuLV) particles to examine how viral structural (Gag) proteins oligomerize at membrane interfaces. Ordered arrays of histidine-tagged Moloney capsid protein (his-MoCA) were obtained on membrane bilayers composed of ph
Glycan and glycosaminoglycan binding properties of stromal cell-derived factor (SDF)-1alpha.: Glycobiology. 2000 Jan;10(1):21-9. Unique Identifier : AIDSLINE MED/20040012; Mbemba E; Gluckman JC; Gattegno L; Laboratoire de Biologie Cellulaire JE 2138, Universite Paris 13,; Faculte de Medecine, 93017 Bobigny, France.; We show here that cell surface glycosaminoglycans (GAGs) are involved in the binding of stromal cell-derived factor (SDF)-1alpha to CD4(+)lymphoid CEM or monocytic U937 cells, inasmuch as pretreating the cells with heparitinase or chondroitinase inhibits SDF-1alpha binding by 40-41% and 31-35%, respectively. Soluble h
HIV and combination therapy: meeting the challenge of a new era.: Br J Nurs. 1999 Jan 14-27;8(1):39-43. Unique Identifier : AIDSLINE MED/99185731; Hodgson I; School of Health Studies, University of Bradford.; With the advent of combination therapy in the treatment of human immunodeficiency virus (HIV) infection, there has been a vast reduction in the number of people admitted to AIDS units as inpatients, and a marked improvement in the quality of life for people infected wi
GP reprimanded for testing patients for HIV without consent [news]: BMJ. 2000 Jan 15;320(7228):135. Unique Identifier : AIDSLINE MED/20100654; Dyer C
Lurigancho prison: Lima's "high school" for criminality.: BMJ. 2000 Jan 15;320(7228):173-5. Unique Identifier : AIDSLINE MED/20100678; Veeken H; Medecins Sans Frontieres, PO Box 10014, 1001 EA Amsterdam,; Netherlands. hans-veeken@amsterdam.msf.org
Effortless unintentional smoking cessation after lamivudine-zidovudine-indinavir post-exposure anti-HIV chemoprophylaxis [letter]: Addiction. 1999 Jan;94(1):139-40. Unique Identifier : AIDSLINE MED/20128491; Simini B; Lucchesi C
Transitions between routes of heroin administration: a study of Caucasian and Indochinese heroin users in south-western Sydney, Australia.: Unique Identifier : AIDSLINE MED/20128484 P; Swift W
DNA typing of primate major histocompatibility complex (Mhc)-DQA1 locus by PCR and dot blot hybridization.: Cell Mol Biol (Noisy-le-grand). 1999 Dec;45(8):1249-56. Unique Identifier : AIDSLINE MED/20106790; Mwenda JM; Shotake T; Yamamoto T; Uchihi R; Bambra CS; Katsumata Y; Institute of Primate Research, National Museums of Kenya,; Nairobi. jmmwenda@arcc.or.ke; Non-human primates (NHPs) are increasingly utilized as models to investigate different aspects of immune responses against self (autoimmunity) and foreign antigens. These animals provide valuable models for testing the efficacy of candidate vaccines against pathogens such as human immunodeficiency virus (HIV) and also
Five years follow-up after 2-chloro deoxyadenosine treatment in thirty patients with hairy cell leukemia: evaluation of minimal residual disease and CD4+ lymphocytopenia after treatment.: Leuk Lymphoma. 1999 Nov;35(5-6):555-65. Unique Identifier : AIDSLINE MED/20075884; Bastie JN; Cazals-Hatem D; Daniel MT; D'Agay MF; Rabian C; Glaisner S; Noel-Walter MP; Dabout D; Flandrin G; Dombret H; Poisson D; Degos L; Castaigne S; Service d'hematologie, Centre hospitalier de Versailles, Le; Chesnay, France.; Between March 1992 and August 1993, thirty patients with hairy cell leukemia (HCL) were treated in a single institution with 2-chlorodeoxyadenosine (2-CdA) for one course (N=27) or two courses at six month interval (N=3). Sixteen patients were previously untreated, 14 had been treated with alpha interferon (alpha IFN)
HTLV-I induced intestinal lymphoma.: Leuk Lymphoma. 1999 Nov;35(5-6):637-40. Unique Identifier : AIDSLINE MED/20075896; Cabrera ME; Labra S; Ford A; Matutes E; Hospital del Salvador, Department of Internal Medicine, Faculty; of Medicine, Universitv of Chile, Santiago de Chile.; We document an unusual case of HTLV-I positive adult T-cell leukaemia lymphoma (ATLL) in a 25 year old Chilean patient who presented with primary small intestinal involvement and during evolution developed a leukaemic phase. Duodenal biopsy showed infiltration by pleomorphic lymphoid cells with a CD45RO+ CD20- phenoty
Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody.: Protein Sci. 1999 Dec;8(12):2686-96. Unique Identifier : AIDSLINE PDB/LCL7; Lescar J; Brynda J; Rezacova P; Stouracova R; Riottot MM; Chitarra V; Fabry M; Horejsi M; Sedlacek J; Bentley GA; Unite d'Immunologie Structurale (URA 1961 CNRS), Departement; d'Immunologie, Institut Pasteur, Paris, France.; The monoclonal antibody 1696, directed against the HIV-1 protease, displays strong inhibitory effects toward the catalytic activity of the enzyme of both the HIV-1 and HIV-2 isolates. This antibody cross-reacts with peptides that include the N-terminus of the enzyme, a region that is well conserved in sequence among d
AIDS in Haiti: a bibliometric analysis.: Bull Med Libr Assoc. 2000 Jan;88(1):56-61. Unique Identifier : AIDSLINE MED/20122074; Macias-Chapula CA; Hospital General de Mexico/Universidad de Colima, Mexico,; Mexico, DF. chapula@data.net.mx; OBJECTIVES: In Haiti , AIDS has become the leading cause of death in sexually active adults. Increasingly, AIDS has become a disease of women and children. Previous bibliometric studies have shown the emergence of Haiti as a leading country in the production of AIDS literature in the
Urinary tract infection: a moving target.: World J Urol. 1999 Dec;17(6):364-71. Unique Identifier : AIDSLINE MED/20119863; Hochreiter WW; Bushman W; Department of Urology, Northwestern University Medical School,; Chicago, IL 60611, USA. werner_hochreiter@compuserve.com; Urinary tract infection is an old problem that continues to present new challenges. The purpose of this special edition is to pull together new basic scientific information regarding the pathogenesis of infection and to review the state of the art in the evaluation and treatment of urinary tract infection in some of t
Occupational exposure to human immunodeficiency virus: what healthcare providers should know.: Cancer Pract. 1998 Nov-Dec;6(6):310-7. Unique Identifier : AIDSLINE MED/99041681; Aboulafia DM; Section of Hematology/Oncology, Virginia Mason Medical Center,; Division of Hematology, University of Washington, Seattle, USA.; PURPOSE: The author reviews the risks of occupational exposure to HIV and provides a rationale for new postexposure guidelines for healthcare workers. OVERVIEW: Approximately 50,000 percutaneous exposures occur yearly among healthcare workers in the United States . Of these, approximate
Molecular methods of measurement of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infection: implications for occupational health practice.: Occup Environ Med. 1999 Nov;56(11):730-4. Unique Identifier : AIDSLINE MED/20123027; Kao JH; Heptonstall J; Chen DS; Department of Internal Medicine, National Taiwan University; College of Medicine, Taipei.; Over the past decade, several molecular techniques for the detection of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) have been developed that have implications for occupational health practice. This review describes the techniques used for qualitative and quantitative detect
Prevalence of and risks for cervical human papillomavirus infection and squamous intraepithelial lesions in adolescent girls: impact of infection with human immunodeficiency virus.: Arch Pediatr Adolesc Med. 2000 Feb;154(2):127-34. Unique Identifier : AIDSLINE MED/20127364; Moscicki AB; Ellenberg JH; Vermund SH; Holland CA; Darragh T; Crowley-Nowick PA; Levin L; Wilson CM; Department of Pediatrics, University of California, San Francisco; 94118, USA. annam@itsa.ucsf.edu; CONTEXT: Data suggest that in adults, human papillomavirus (HPV) infections and their sequalae, squamous intraepithelial lesions (SILs), occur more commonly among human immunodeficiency (HIV)-infected women because of the HIV-associated CD4+ T-cell immunosuppression. Since adolescents are more likely to be early in th
Fathers and child neglect.: Arch Pediatr Adolesc Med. 2000 Feb;154(2):135-41. Unique Identifier : AIDSLINE MED/20127365; Dubowitz H; Black MM; Kerr MA; Starr RH Jr; Harrington D; Department of Paediatrics, University of Maryland School of; Medicine, Baltimore 21291, USA. hdubowit@umaryland.edu; OBJECTIVE: To examine the association between father involvement and child neglect. DESIGN: Cohort study. SETTING: Participants were recruited from an inner-city pediatric primary care clinic and a clinic for children at risk for human immunodeficiency virus infection in a teaching hospital. PARTICIPANTS: Mothers and
[Effect of needle and syringe exchange programs on the spread of viral hepatitis C]: Epidemiol Mikrobiol Imunol. 1999 Nov;48(4):171-8. Unique Identifier : AIDSLINE MED/20122807; Trmal J; Kellerova J; Koblizkova R; Krpalkova H; Holasova J; Krajska hygienicka stanice, Usti nad Labem.; The authors examined a total of 224 clients (147 men and 77 women) of the Contact centre for drug-dependent subjects Drug out in Usti nad Labem. The subjects, parenteral abusers of hard drugs. The majority of examined subjects were 20-24 years old and accounted for 50.9% of the whole group. In all the history of abu
Cell binding, uptake and cytosolic partition of HIV anti-gag phosphodiester oligonucleotides 3'-linked to cholesterol derivatives in macrophages.: Unique Identifier : AIDSLINE MED/20095897; LeDoan T; Etore F; Tenu JP; Letourneux Y; Agrawal S; The purpose of this study is to evaluate the cell interactions of a new class of compounds composed of phosphodiester oligonucleotides linked to the cholesterol group at position 3, 7, or 22 of the steroid structure. The resulting conjugates were assessed for their capacity to bind, penetrate and partition in the cyto
Comparative molecular field analysis (CoMFA) and docking studies of non-nucleoside HIV-1 RT inhibitors (NNIs).: Bioorg Med Chem. 1999 Nov;7(11):2283-92. Unique Identifier : AIDSLINE MED/20095899; Barreca ML; Carotti A; Carrieri A; Chimirri A; Monforte AM; Calace MP; Rao A; Dipartimento Farmaco-Chimico, Universita di Messina, Italy.; A set of TIBO derivatives endowed with reverse transcriptase (RT) inhibitory activity were analyzed by comparative molecular field analysis (CoMFA). Besides conventional steric and electrostatic fields, molecular lipophilicity potential (MLP) was also used as a third field in CoMFA. An informative and statistically si
Synthesis and anti-HIV evaluation of 2',3'-dideoxy imidazo- and nu-triazolo[4,5-d]pyridazine nucleosides.: Bioorg Med Chem. 1999 Nov;7(11):2373-9. Unique Identifier : AIDSLINE MED/20095907; Bussolari JC; Panzica RP; Department of Biomedical Sciences, University of Rhode Island,; Kingston 02881-0809, USA.; The syntheses of the 2 -deoxy and 2 ,3 -dideoxynucleosides of 2,8-diaza-3-deazainosine and the 2 ,3 -dideoxynucleoside of 2-aza-3-deazainosine were achieved and the pathways leading to these novel nucleosides are described. The preparation of the 2 ,3 -dideoxynucleoside (1) of 2-aza-3-deazainosine involved deoxygenati
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues.: Bioorg Med Chem. 1999 Nov;7(11):2427-36. Unique Identifier : AIDSLINE MED/20095913; Breslin HJ; Kukla MJ; Kromis T; Cullis H; De Knaep F; Pauwels R; Andries K; De Clercq E; Janssen MA; Janssen PA; Janssen Research Foundation, Spring House, PA 19477, USA.; 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(- 1 H)-ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication, as reported in detail in our prior publications. Since our earlier reports, we have modified the TIBO structures 1 by removing the 5-membered ring of 1, generating 1,3,4,5
Quantitative structure-activity relationship studies on cyclic cyanoguanidines acting as HIV-1 protease inhibitors.: Bioorg Med Chem. 1999 Nov;7(11):2549-53. Unique Identifier : AIDSLINE MED/20095926; Gupta SP; Babu MS; Birla Institute of Technology and Science, Pilani, India.; A quantitative structure-activity relationship study has been performed on some cyclic cyanoguanidines that inhibit the enzyme HIV-1 protease (HIV-1-PR) and exhibit antiviral potency, and the results have been compared with those of cyclic urea derivatives. Both the enzyme inhibition activity and antiviral potency in
In search of new chemical entities with spermicidal and anti-HIV activities.: Bioorg Med Chem. 1999 Nov;7(11):2607-13. Unique Identifier : AIDSLINE MED/20095932; Srivastava S; Bajpai LK; Batra S; Bhaduri AP; Maikhuri JP; Gupta G; Dhar JD; Medicinal Chemistry Division, Central Drug Research Institute,; Lucknow, India.; Several compounds belonging to 2-isoxazolines (4,5a-c), isoxazoles (3,6a-c) and 1-amino-1-cycloalkyl-2-substituted phenyl ethanes (16-18,a-e) have been synthesised and found to possess spermicidal activity. Out of these a couple of compounds (5a and 6a) exhibit anti-HIV activity.
T cells work together to fight cancer.: Curr Biol. 1999 Sep 23;9(18):R695-7. Unique Identifier : AIDSLINE MED/99439913; Cerundolo V; Institute of Molecular Medicine Nuffield Department of Medicine; Oxford, OX3 9DS, UK. vcerundo@worf.molbiol.ox.ac.uk; Recent studies have identified new melanoma antigens that are recognised by CD4(+) T cells. Analysis of tumour-specific CD4(+) T-cell responses may lead to the development of optimal anti-cancer vaccines that can induce an orchestrated effort of tumour-specific CD4(+) and CD8(+) T cells in the fight against cancer.
Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity.: Curr Biol. 1999 Dec 16-30;9(24):1489-92. Unique Identifier : AIDSLINE MED/20076702; Ott M; Schnolzer M; Garnica J; Fischle W; Emiliani S; Rackwitz HR; Verdin E; Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, 69120,; Germany.; The human immunodeficiency virus 1 (HIV-1) Tat protein activates transcriptional elongation by recruiting the positive transcription elongation factor (pTEFb) complex to the TAR RNA element, which is located at the 5 extremity of all viral transcripts [1-3]. Tat also associates in vitro and in vivo with the transcrip
Conventional and non-conventional recognition of non-peptide antigens by T lymphocytes.: C R Acad Sci III. 1999 Nov;322(11):919-24. Unique Identifier : AIDSLINE MED/20111553; Belmant C; Espinosa E; Halary F; Apostolou I; Sicard H; Peyrat MA; Vercellone A; Kourilsky P; Gachelin G; Poupot R; Bonneville M; Fournie JJ; Inserm unite 395, CHU Purpan, Toulouse, France.
New prospects for the development of a vaccine against human immunodeficiency virus type 1. An overview.: C R Acad Sci III. 1999 Nov;322(11):959-66. Unique Identifier : AIDSLINE MED/20111559; Girard M; Habel A; Chanel C; Departement de virologie, Institut Pasteur, Paris, France.; mgirard@pasteur.fr; During the past few years, definite progress has been made in the field of human immunodeficiency virus type 1 (HIV-1) vaccines. Initial attempts using envelope gp120 or gp140 from T-cell line-adapted (TCLA) HIV-1 strains to vaccinate chimpanzees showed that neutralizing antibody-based immune responses were protective
Cytokine production from murine CD4 and CD8 cells after mannan-MUC1 immunization.: J Interferon Cytokine Res. 1999 Dec;19(12):1373-9. Unique Identifier : AIDSLINE MED/20102244; Lees CJ; Apostolopoulos V; McKenzie IF; The Austin Research Institute, Heidelberg, Victoria, Australia.; Immunotherapy with oxidized mannan-MUC1 fusion protein (M-FP) leads to a T1 immune response characterized by the generation of cytotoxic T lymphocytes (CTL), few antibodies, secretion of interleukin-2 ( IL-2 ), IL-12, and interferon-gamma and tumor protection. Immunother
The multi-epitope polypeptide approach in HIV-1 vaccine development.: Genet Anal. 1999 Nov;15(3-5):149-53. Unique Identifier : AIDSLINE MED/20061869; Cano CA; Jefe Departamento SIDA, Centro de Ingenieria Genetica y; Biotecnologia, La Habana, Playa, Cuba. carlos.duarte@cigb.edu.cu; The application of a preventive HIV vaccine is the only hope for most developing countries to halt the AIDS pandemic. A project aimed to develop a preventive AIDS vaccine is being carried out since 1992 by three Cuban research institutions: Centro de Ingenieria Genetica y Biotecnologia de La Habana, Instituto de Medic
The optimal use of IRES (internal ribosome entry site) in expression vectors.: Genet Anal. 1999 Nov;15(3-5):161-5. Unique Identifier : AIDSLINE MED/20061871; Attal J; Theron MC; Houdebine LM; Laboratoire de Differenciation Cellulaire, Institut National de; la Recherche Agronomique, Jousy-en-Josas, France.; In higher eucaryotes, natural bicistronic mRNA have been rarely found so far. The second cistron of constructed bicistronic mRNAs is generally considered as not translated unless special sequences named internal ribosome entry site (IRES) are added between the two cistrons. These sequences are believed to recruit ribo
UN acknowledges HIV/AIDS as a threat to world peace [news]: Nat Med. 2000 Feb;6(2):117. Unique Identifier : AIDSLINE MED/20124147; Birmingham K
Vaccines and the induction of functional antibodies: time to look beyond the molecules of natural infection?: Nat Med. 2000 Feb;6(2):123-5. Unique Identifier : AIDSLINE MED/20124156; Burton DR; Parren PW; Department of Immunology and Molecular Biology, The Scripps; Research Institute, La Jolla, California 92037, USA.; burton@scripps.edu; Infection with some pathogens induces weak functional antibody responses that are non-protective, and there has been some skepticism about a role for antibodies in vaccine design. However, newer data show that antibodies can protect against infection with these pathogens, and new methods to elicit production of functi
IgG surfaces as an important component in mucosal protection [news]: Nat Med. 2000 Feb;6(2):129-30. Unique Identifier : AIDSLINE MED/20124158; Robert-Guroff M
Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.: Nat Med. 2000 Feb;6(2):200-6. Unique Identifier : AIDSLINE MED/20124178; Baba TW; Liska V; Hofmann-Lehmann R; Vlasak J; Xu W; Ayehunie S; Cavacini LA; Posner MR; Katinger H; Stiegler G; Bernacky BJ; Rizvi TA; Schmidt R; Hill LR; Keeling ME; Lu Y; Wright JE; Chou TC; Ruprecht RM; Department of Cancer Immonology and AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.; Although maternal human immunodeficiency virus type 1 (HIV-1) transmission occurs during gestation, intrapartum and postpartum (by breast-feeding), 50-70% of all infected children seem to acquire HIV-1 shortly before or during delivery. Epidemiological evidence indicates that mucosal exposure is an important aspect of
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.: Nat Med. 2000 Feb;6(2):207-10. Unique Identifier : AIDSLINE MED/20124179; Mascola JR; Stiegler G; VanCott TC; Katinger H; Carpenter CB; Hanson CE; Beary H; Hayes D; Frankel SS; Birx DL; Lewis MG; Division of Retrovirology, Walter Reed Army Institute of Research; and Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.; The development of the human immunodeficiency virus-1 (HIV-1)/simian immunodeficiency virus (SIV) chimeric virus macaque model (SHIV) permits the in vivo evaluation of anti-HIV-1 envelope glycoprotein immune responses. Using this model, others, and we have shown that passively infused antibody can protect against an i
Orthotopic human lung carcinoma xenografts in BALB/c mice immunosuppressed with anti-CD4 monoclonal antibodies and chronic alcohol consumption.: Cancer. 2000 Jan 15;88(2):468-79. Unique Identifier : AIDSLINE MED/20108758; Hunt JD; Robert EG; Zieske AW; Bautista AP; Bukara M; Lei D; Shellito JE; Nelson S; Kolls JK; Skrepnik N; Department of Biochemistry and Molecular Biology, Louisiana State; University Health Sciences Center, New Orleans, Louisiana 70112,; USA.; BACKGROUND: The role of the immune system in the surveillance of the body for cancer cells is well established. Human tumor cells do not survive in mice with intact immune systems, but they propagate in athymic nude mice. Presumably, the lack of a thymus gland and consequent loss of T lymphocytes results in a seriousl
Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders.: Unique Identifier : AIDSLINE MED/20070524; Banks WA; GRECC, Veterans Affairs Medical Center-St.Louis and Saint Louis; University School of Medicine, Department of Internal Medicine,; St. Louis, MO 63106, USA.; The blood-brain barrier (BBB) regulates the passage of solutes between the CNS and the blood. The BBB not only restricts the entry of serum proteins into the CNS, but it also controls the passage of nutrients, electrolytes, vitamins, minerals, free fatty acids, peptides, and regulatory proteins in both the brain to bl
Model systems for studies of leukocyte migration across the blood brain barrier.: J Neurovirol. 1999 Dec;5(6):579-90. Unique Identifier : AIDSLINE MED/20070527; Persidsky Y; Department of Pathology and Microbiology, Center for; Neurovirology and Neurodegenerative Disorders, 985215 Nebraska; Medical Center, Omaha, Nebraska, NE 68198-5215 USA.; The blood - brain barrier (BBB) plays a crucial role in central nervous system (CNS) homeostasis. Serving as the brain s protective shield it regulates soluble factor and cellular exchanges from blood to brain. Critical to its function, the BBB is composed of brain microvascular endothelial cells (BMVEC), a collagen m
Chemokine receptors and virus entry in the central nervous system.: J Neurovirol. 1999 Dec;5(6):643-58. Unique Identifier : AIDSLINE MED/20070533; Gabuzda D; Wang J; Department of Cancer Immunology & AIDS, Dana-Farber Cancer; Institute, JF712, 44 Binney Street, Boston, Massachusetts, MA; 02115, USA.; Several members of the chemokine receptor family are used as coreceptors together with CD4 for HIV and SIV entry in the central nervous system (CNS). CCR5 is the major coreceptor for HIV-1 infection of macrophages and microglia, the major target cells for HIV-1 infection in the CNS. CXCR4 and CCR3 are also expressed o
Interactions between macrophages and brain microvascular endothelial cells: role in pathogenesis of HIV-1 infection and blood - brain barrier function.: J Neurovirol. 1999 Dec;5(6):659-69. Unique Identifier : AIDSLINE MED/20070534; Nottet HS; Eijkman-Winkler Institute of Microbiology, Infectious Diseases; and Inflammation, section of Neuroimmunology, Utrecht University,; Utrecht, The Netherlands.; Monocytes have been shown to infiltrate in brain tissue during various neurological disorders including AIDS dementia complex. The presence of an excess of activated macrophages in brain tissue is accompanied by tissue damage resulting in a loss in neuronal function and viability.
HIV infection of choroid plexus in AIDS and asymptomatic HIV-infected patients suggests that the choroid plexus may be a reservoir of productive infection.: J Neurovirol. 1999 Dec;5(6):670-7. Unique Identifier : AIDSLINE MED/20070535; Petito CK; Chen H; Mastri AR; Torres-Munoz J; Roberts B; Wood C; Department of Pathology, University of Miami School of; Medicine-Jackson Memorial Hospital, Miami, Florida, FL 33136,; USA.; The choroid plexus (CPx) may be an important site of viral dissemination since monocytes and dendritic cells in its stroma are infected with HIV in AIDS patients and since the ratio of CPx to brain infection is more than 2 : 1. In order to see if CPx infection also develops in asymptomatic (ASY) HIV-infected patients,
Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes.: J Neurovirol. 1999 Dec;5(6):678-84. Unique Identifier : AIDSLINE MED/20070536; Woodman SE; Benveniste EN; Nath A; Berman JW; Department of Pathology, Albert Einstein College of Medicine; Bronx, New York, NY 10461, USA.; AIDS encephalitis is a frequent consequence of CNS HIV infection, especially in children. One of its many characteristics is a leukocyte infiltrate that is believed to contribute to the production of cytokines, chemokines and neurotoxic factors resulting in CNS damage. Entry of such leukocytes into the CNS is mediated
Role of HIV-1 Tat and CC chemokine MIP-1alpha in the pathogenesis of HIV associated central nervous system disorders.: J Neurovirol. 1999 Dec;5(6):685-94. Unique Identifier : AIDSLINE MED/20070537; Bonwetsch R; Croul S; Richardson MW; Lorenzana C; Valle LD; Sverstiuk AE; Amini S; Morgello S; Khalili K; Rappaport J; Department of Neurology, MCP Hahnemann University, 245 North 15th; Street, Philadelphia, PA 19102, USA.; Two syndromes affecting cognitive and motor function in the setting of AIDS have been described as HIV encephalopathy (HIVE) and progressive multifocal leukoencephalopathy (PML). HIVE is characterized by the presence of microglial nodules with accompanying astrocytosis. PML is a fatal demyelinating disease of the whit
Alterations in blood-brain barrier glucose transport in SIV-infected macaques.: J Neurovirol. 1999 Dec;5(6):695-702. Unique Identifier : AIDSLINE MED/20070538; Mankowski JL; Queen SE; Kirstein LM; Spelman JP; Laterra J; Simpson IA; Adams RJ; Clements JE; Zink MC; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland, MD 21205, USA.; The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key
Microglial activation and neurological symptoms in the SIV model of NeuroAIDS: association of MHC-II and MMP-9 expression with behavioral deficits and evoked potential changes.: Neurobiol Dis. 1999 Dec;6(6):486-98. Unique Identifier : AIDSLINE MED/20070559; Berman NE; Marcario JK; Yong C; Raghavan R; Raymond LA; Joag SV; Narayan O; Cheney PD; Department of Anatomy and Cell Biology, Marion Merrell Dow; Laboratories, Kansas City, KS 66160-7400, USA.; HIV-1 causes cognitive and motor deficits and HIV encephalitis (HIVE) in a significant proportion of AIDS patients. Neurological impairment and HIVE are thought to result from release of cytokines and other harmful substances from infected, activated microglia. In this study, the quantitative relationship between micr
[Changes in various parameters of the mouse immune status subjected to chronic social conflict]: Ross Fiziol Zh Im I M Sechenova. 1999 Aug;85(8):1035-42. Unique Identifier : AIDSLINE MED/20108208; Griazeva NI; Shurlygina AV; Verbitskaia LV; Mel'nikova EV; Kudriavtseva NN; Trufakin VA; Institute of Clinical and Experimental Lymphology, Russian Acad.; Med. Sci., Siberian Branch, Novosibirsk, Russia.; Recurrent experience of a social confrontation was shown to increase the per cent of cleavage nucleus neutrophiles in both mice-participants, activation of the lymphocyte dehydrogenase, and reduction of number of the CDA+ and CD8+ T-lymphocytes. Dynamic character of changes in the metabolism parameters and the number
Acute, multiple-dose, and genetic toxicology of AR177, an anti-HIV oligonucleotide.: Toxicol Sci. 2000 Jan;53(1):63-70. Unique Identifier : AIDSLINE MED/20117247; Wallace TL; Gamba-Vitalo C; Loveday KS; Cossum PA; Aronex Pharmaceuticals, Inc., The Woodlands, Texas 77381, USA.; twallace@aronex-pharm.com; AR177 (Zintevir) is a 17-mer oligonucleotide that has been shown to have anti-HIV activity and to be a potent HIV-1 integrase inhibitor in vitro, and is among the first oligonucleotides to enter human clinical trials. Acute and multiple-dose intravenous toxicity studies were performed in mice, and genetic toxicity stu
Bridging the gap. Bringing new antiretroviral medications into the clinic.: Adv Nurse Pract. 1999 Jan;7(1):24-30; quiz 31-2. Unique Identifier : AIDSLINE MED/99154435; Williams A; Yale University School of Nursing, New Haven, Conn., USA.; Highly active antiretroviral therapy (HAART) is a strategy in which clinicians introduce potent combinations of antiretroviral medications early in the course of HIV infection. The intent is to suppress viral replication as completely as possible to forestall irreversible immune system damage. Antiretroviral agents fa
Targeting RNA with small molecules.: Curr Med Chem. 2000 Jan;7(1):73-98. Unique Identifier : AIDSLINE MED/20105715; Wilson WD; Li K; Department of Chemistry, Georgia State University, Atlanta, GA; 30303, USA. chewdw@panther.gsu.edu; Therapeutic targeting of RNA is not as well-developed as with DNA and proteins, and the many structures and functions of RNA suggest that it is an underutilized target. As with DNA, RNA has heterocyclic bases and base pairs with a highly anionic backbone, but as with proteins, RNA can fold into complex tertiary struct
Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.: Nucleosides Nucleotides. 1999 Oct;18(10):2233-52. Unique Identifier : AIDSLINE MED/20084101; Cavalcanti SC; Xiang Y; Newton MG; Schinazi RF; Cheng YC; Chu CK; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens 30602, USA.; A series of 2 ,3 -dideoxy-2 -fluoro-L-threo-pentofuranosyl nucleosides has been synthesized as potential antiviral agents. The synthesized compounds were evaluated against HIV-1, HBV, HSV-1, and HSV-2. Among the synthesized analogues, only the cytosine derivative showed moderate antiviral activity against HIV and HBV.
Synthesis of new nucleoside analogues comprising a geminal difluorocyclopropane moiety as potential antiviral/antitumor agents.: Nucleosides Nucleotides. 1999 Oct;18(10):2285-300. Unique Identifier : AIDSLINE MED/20084103; Qiu YL; Zemlicka J; Department of Chemistry, Barbara Ann Karmanos Cancer Institute,; Wayne State University School of Medicine, Detroit, Michigan; 48201-1379, USA.; Geminal difluorocyclopropane analogues of nucleosides 7a-7e were synthesized. Compounds 7a and 7c-7e were obtained by alkylation of nucleic acid bases or their appropriate precursors with (cis)-1-benzyloxymethyl-2-bromomethyl-3,3-difluorocyclopropane+ ++ (8). Analogue 7b was prepared by hydrolysis of 2-amino-6-chlorop
Synthesis of some pyridine ribosides and their biological activity.: Nucleosides Nucleotides. 1999 Oct;18(10):2301-6. Unique Identifier : AIDSLINE MED/20084104; Attia AM; Mansour HA; Almehdi AA; Abbasi MM; Department of Chemistry, Faculty of Education, Tanta University,; Kafr El- Sheikh, Egypt.; A synthesis of 1-(beta-D-ribofuranosyl)-pyridin-2-thiones via reaction of 3-cyanopyridin-2(1H)-thiones with 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide under basic conditions, followed by hydrolysis with methanolic ammonia is reported.
Synthesis and biological activity of modified thiopyrimidine nucleosides.: Nucleosides Nucleotides. 1999 Oct;18(10):2307-15. Unique Identifier : AIDSLINE MED/20084105; Attia AM; Sallam MA; Almehdi AA; Abbasi MM; Department of Chemistry, Faculty of Education, Tanta University,; Kafr El- Sheikh, Egypt.; N3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-methylthiouracil and their 5-bromo derivatives have been synthesized by coupling an alpha-acetobromosugar with the corresponding thiouracil. The new modified thiouridine analogues were evaluated for their inhibitory activity against Human Immunode
Synthesis and anti-retroviral activity of O,O'-bis(3'-azido-2',3'-dideoxythymidin-5'-yl) phosphoramidate derivatives.: Nucleosides Nucleotides. 1999 Oct;18(10):2317-25. Unique Identifier : AIDSLINE MED/20084106; Kers I; Stawinski J; Girardet JL; Imbach JL; Perigaud C; Gosselin G; Aubertin AM; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm; University, Sweden.; A simple and efficient protocol for the preparation of various symmetrical dinucleoside phosphoramidates derived from AZT , is presented. It consists of the phosphonylation of AZT with phosphonic acid in the presence of DCC to produce the symmetrical H
Anti-human immunodeficiency virus type 1 of a two-strand-system targeted to the polypurine tract.: Int J Mol Med. 2000 Feb;5(2):125-32. Unique Identifier : AIDSLINE MED/20107380; Hiratou T; Miyano-Kurosaki N; Tsukahara S; Tamura Y; Takai K; Yamamoto N; Takaku H; Department of Industrial Chemistry, Chiba Institute of; Technology, Narashino, Chiba 275-0016, Japan.; The polypurine tract (PPT) is highly conserved among the known human immunodeficiency virus (HIV)-1 strains, and is a possible target for triplex formation. We show the effects of triple-helix formation by assays of primer extension inhibition in vitro, using a two-strand-system (FTFOs) targeted to the PPT of HIV-1. T
Castleman's disease.: Adv Clin Path. 1999 Jan-Apr;3(1-2):11-22. Unique Identifier : AIDSLINE MED/20122659; Palestro G; Turrini F; Pagano M; Chiusa L; Departement of Biomedical Science and Human Oncology, University; of Torino, Torino, I-10126, Italy. palestro@molinette.unito.it; Castleman s disease (CD) is a rare atypical lymphoproliferative disorder whose morphology, soon after the original presentation of Castleman et al., has been definitely subdivided in a hyaline vascular (HV) and plasma cell (PC) histopathological pattern, with intermediate variants. The former occurs much more frequent
[A study of clinical symptoms, muscle pathology, therapeutic response, and prognosis of myositis in patients with HTLV-1 associated myelopathy (HAM)]: Rinsho Shinkeigaku. 1999 Aug;39(8):807-11. Unique Identifier : AIDSLINE MED/20053070; Inose M; Higuchi I; Yoshimine K; Arimura K; Osame M; Izumo S; Hokezu Y; Third Department of Internal Medicine, Faculty of Medicine; Kagoshima University.; Myositis is one of well-known complications of HTLV-1 associated myelopathy (HAM). On twelve HAM patients, 10 women and 2 men complicated with myositis, we examined their clinical symptoms, muscle pathology, and therapeutic response. Clinical examination revealed gait disturbance in 10, weakness of upper limbs in 6, m
[A case of HTLV-I associated myelopathy presenting with cerebellar signs as initial and principal manifestations]: Rinsho Shinkeigaku. 1999 Aug;39(8):852-5. Unique Identifier : AIDSLINE MED/20053080; Fujiki N; Oikawa O; Matsumoto A; Tashiro K; Department of Neurology, Sapporo City General Hospital.; We reported a 75-year-old woman with HTLV-I associated myelopathy (HAM) presenting with cerebellar signs. She was admitted to our hospital because of walking unsteadiness, which initially appeared 3 years previously with gradual worsening. Neurological examination revealed limb and truncal ataxia, cerebellar type dysf
Inability of activated cord blood T lymphocytes to perform Th1-like and Th2-like responses: implications for transplantation.: J Hematother Stem Cell Res. 1999 Aug;8(4):381-5. Unique Identifier : AIDSLINE MED/20097641; D'Arena G; Musto P; Cascavilla N; Minervini MM; Di Giorgio G; Maglione A; Carotenuto M; Division of Hematology, IRCSS Casa Sollievo della Sofferenza; Hospital, San Giovanni Rotondo, Italy.; Cytokines secreted by alloreactive donor T cells play a crucial role in the pathogenesis of both acute and chronic GvHD, a complication of allogeneic hematopoietic transplants that occurs at a lower incidence and severity when human umbilical cord blood (HUCB) is used. Our five-dimensional flow cytometric study perfor
Evaluation of stabilized whole blood control materials for lymphocyte immunophenotyping.: Cytometry. 1999 Dec 15;38(6):268-73. Unique Identifier : AIDSLINE MED/20057744; Nicholson JK; Hubbard M; Dawson CD; HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and; TB Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA. jkn1@cdc.gov; We evaluated stabilized whole blood control materials for their performance as a routine control material for immunophenotyping using flow cytometry. These materials serve as the method control, controlling for both the binding of monoclonal antibodies to the cells and the efficiency of the red-blood-cell lysing reage
Didanosine: an updated review of its use in HIV infection.: Drugs. 1999 Dec;58(6):1099-135. Unique Identifier : AIDSLINE MED/20114814; Perry CM; Noble S; Adis International Limited, Mairangi Bay, Auckland, New Zealand.; demail@adis.co.nz; Didanosine, like zidovudine, stavudine and lamivudine, is a nucleoside analogue reverse transcriptase inhibitor (NRTI). In the target cell for HIV, didanosine is converted to its active moiety, dideoxyadenosine-5 -triphosphate (ddATP), which inhibits
Indinavir: a review of its use in the management of HIV infection.: Unique Identifier : AIDSLINE MED/20114816; Plosker GL; Noble S; Indinavir is a protease inhibitor used in the treatment of patients with HIV infection. Combination antiretroviral therapy with indinavir plus 2 nucleoside reverse transcriptase inhibitors (NRTIs) is associated with greater reductions in viral load, g
New uses for old drugs in HIV infection: the role of hydroxyurea, cyclosporin and thalidomide.: Drugs. 1999 Dec;58(6):953-63. Unique Identifier : AIDSLINE MED/20114806; Ravot E; Lisziewicz J; Lori F; Research Institute for Genetic and Human Therapy, I.R.C.C.S.,; Policlinico San Matteo, Pavia, Italy.; The tenacious effort to develop new, specific agents to treat HIV infection is currently accompanied by a reconsideration of existing drugs on the basis of their known or putative effects on the retroviral life cycle and/or the tuning of immune mechanisms. Three specific older compounds that interfere with HIV infec
Enhancement of the anti-tumor activity of a peripheral blood progenitor cell graft by mobilization with interleukin 2 plus granulocyte colony-stimulating factor in patients with advanced breast cancer.: Exp Hematol. 2000 Jan;28(1):96-103. Unique Identifier : AIDSLINE MED/20121768; Burns LJ; Weisdorf DJ; DeFor TE; Repka TL; Ogle KM; Hummer C; Miller JS; Department of Medicine, University of Minnesota, Minneapolis; 55455, USA. burns019@tc.umn.edu; OBJECTIVE: Autologous interleukin 2 ( IL-2 )-activated natural killer (NK) cells kill a broad spectrum of tumor targets, including breast cancer. We hypothesized that mobilization with IL-2 and granulocyte colony-stimulating factor (G-CSF) for collection of peripheral bl
Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency.: Graefes Arch Clin Exp Ophthalmol. 1999 Dec;237(12):952-61. Unique Identifier : AIDSLINE MED/20119659; Joussen AM; Germann T; Kirchhof B; Department of Ophthalmology, Technical University of Aachen; (RWTH), Germany. JoussenA@aol.com; Neovascular diseases are the leading causes of blindness in humans. Although several promising compounds have been isolated, pharmacological treatment remains difficult. Thalidomide has inhibitory effects on angiogenesis in the corneal micropocket assay. However, the results vary considerably depending on the administ
HIV testing behaviors and attitudes regarding HIV/AIDS of adults aged 50-64.: Gerontologist. 1999 Dec;39(6):687-94. Unique Identifier : AIDSLINE MED/20116458; Mack KA; Bland SD; Division of Adult and Community Health, Centers for Disease; Control and Prevention, Atlanta, GA 30341-3724, USA. kim9@cdc.gov; This article explores knowledge, attitudes, and behaviors regarding HIV/AIDS for persons aged 50-64 by using data from the 1996 Behavioral Risk Factor Surveillance System. It examines what percentage have been tested for HIV, where and why they have been tested, knowledge about condom effectiveness, and self-perceived
Outcome of lamivudine resistant hepatitis B virus infection in the liver transplant recipient.: Gut. 2000 Jan;46(1):107-13. Unique Identifier : AIDSLINE MED/20069510; Mutimer D; Pillay D; Shields P; Cane P; Ratcliffe D; Martin B; Buchan S; Boxall L; O'Donnell K; Shaw J; Hubscher S; Elias E; Liver and Hepatobiliary Unit, Queen Elizabeth Hospital,; Birmingham B15 2TH, UK.; BACKGROUND: In many transplant centres lamivudine is an important component of prophylaxis against, and treatment of, hepatitis B virus (HBV) graft infection. Drug resistant HBV species with specific polymerase mutations may emerge during lamivudine treatment. AIMS: To examine the clinical consequences of graft infect
[Antiretroviral agent nevirapine: its pharmacological action and potential for clinical use]: Nippon Yakurigaku Zasshi. 1999 Oct;114(4):205-11. Unique Identifier : AIDSLINE MED/20051622; Takeuchi S; Osugi T; Department of Pharmacology, Kawanishi Pharma Research Institute,; Nippon Boehringer Ingelheim Co., Ltd., Japan.; Nevirapine (NVP) is a potent noncompetitive inhibitor of the reverse transcriptase enzyme, which is necessary for HIV replication. NVP selectively inhibits HIV-1 but not HIV-2 and any of the human DNA polymerases. NVP is active against ZDV-resistant HIV-1 and synergistic with nonnucleoside reverse transcriptase inhibi
Chagas' disease of the cervix uteri in a patient with acquired immunodeficiency syndrome.: Hum Pathol. 2000 Jan;31(1):120-2. Unique Identifier : AIDSLINE MED/20127689; Concetti H; Retegui M; Perez G; Perez H; Department of Pathology, Hospital Juan A. Fernandez, Gobierno; Autonomo de la Ciudad de Buenos Aires, Argentina.; A 27-year-old woman with the acquired immunodeficiency syndrome and endocervical Chagas disease is reported. The patient was a cocaine addict, and her sexual partner was also human immunodeficiency virus (HIV)-positive. Her past medical history included a son who died 3 days after birth due to congenital Chagas dise
Impact of human immunodeficiency virus infection on the histological features of chronic hepatitis C: a case-control study. The MULTIVIRC group.: Hum Pathol. 2000 Jan;31(1):69-74. Unique Identifier : AIDSLINE MED/20127682; Allory Y; Charlotte F; Benhamou Y; Opolon P; Le Charpentier Y; Poynard T; Service d'Anatomie et de Cytologie Pathologiques, Groupe; Hospitalier Pitie-Salpetriere, Paris, France.; Hepatitis C virus (HCV) is frequently encountered in human immunodeficiency virus (HIV)-infected patients because of common routes of transmission. Previous studies suggested that HIV infection impaired the natural course of chronic hepatitis C, with a more rapid progression to cirrhosis. However, these studies did no
The histological spectrum of visceral leishmaniasis caused by Leishmania infantum MON-1 in acquired immune deficiency syndrome.: Hum Pathol. 2000 Jan;31(1):75-84. Unique Identifier : AIDSLINE MED/20127683; Hofman V; Marty P; Perrin C; Saint-Paul MC; Le Fichoux Y; Michiels JF; Glaichenhaus N; Pratlong F; Hofman P; Department of Pathology, Pasteur Hospital and the Molecular and; Cellular Pharmacology Institut, University of Nice Sophia; Antioplis, France.; Visceral leishmaniasis (VL) due to Leishmania infantum is endemic in Southern France and can be considered as an opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). Co-infection with Leishmania sp. and human immunodeficiency virus (HIV) is emerging,
Alternative pathways for processing exogenous and endogenous antigens that can generate peptides for MHC class I-restricted presentation.: Immunol Rev. 1999 Dec;172:131-52. Unique Identifier : AIDSLINE MED/20097561; Reimann J; Schirmbeck R; Department of Medical Microbiology and Immunology, University of; Ulm, Germany. joerg.reimann@medizin.uni-ulm.de; The concept of distinct endogenous and exogenous pathways for generating peptides for MHC-I and MHC-II-restricted presentation to CD4+ or CD8+ T cells fits well with the bulk of experimental data. Nevertheless, evidence is emerging for alternative processing pathways that generate peptides for MHC-I-restricted present
The intestinal epithelial cell: processing and presentation of antigen to the mucosal immune system.: Immunol Rev. 1999 Dec;172:315-24. Unique Identifier : AIDSLINE MED/20097574; Campbell N; Yio XY; So LP; Li Y; Mayer L; Mount Sinai Medical Center, Immunobiology Center, New York, New; York 10029, USA.; The immunologic tone of the intestinal tract is one of suppressed or highly regulated responses. While there are several components (intrinsic and extrinsic to the gut-associated lymphoid tissue) responsible for this immunologically suppressed tone, the intestinal epithelial call (IEC) has been proposed as a key playe
Generating MHC class I ligands from viral gene products.: Immunol Rev. 1999 Dec;172:97-108. Unique Identifier : AIDSLINE MED/20097558; Yewdell J; Anton LC; Bacik I; Schubert U; Snyder HL; Bennink JR; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, NIH, Bethesda, Maryland 20892-0440, USA.; jyewdell@nih.gov; MHC class I molecules function to present peptides comprised of eight to 11 residues to CD8+ T lymphocytes. Here we review the efforts of our laboratory to understand how cells generate such peptides from viral gene products. We particularly focus on the nature of substrates acted on by cytosolic proteases, the contri
Immune reactions to Listeria monocytogenes in the brain.: Immunobiology. 1999 Dec;201(2):188-95. Unique Identifier : AIDSLINE MED/20097142; Schluter D; Buck C; Reiter S; Meyer T; Hof H; Deckert-Schluter M; Institut fur Med. Mikrobiologie und Hygiene, Universitat; Heidelberg, Universitatsklinikum Mannheim, Germany.; dirk.schlueter@imh.ma.uni-heidelberg.de; Listeria monocytogenes (LM) is a common pathogen of cerebral infections. Experimental studies in mice have revealed that epithelial cells of the choroid plexus, ependymal cells, macrophages/microglia, and neurons are the target cells of LM. For the intracerebral pathogenesis of LM cell-to-cell spread via phospholipase
A knockout approach to understanding CD8+ cell effector mechanisms in adaptive immunity to Listeria monocytogenes.: Immunobiology. 1999 Dec;201(2):196-204. Unique Identifier : AIDSLINE MED/20097143; Harty JT; White D; Department of Microbiology, University of Iowa, Iowa City, USA.; john-harty@uiowa-edu; In the described experimental approach, we use an attenuated LM strain to evoke LM specific CD8+ T cell responses. In this fashion, we can immunize immunocompromised gene knockout mice, that would succumb to low level infection with virulent LM. We then generate antigen matched, LM-specific CD8+ T cell lines from wild
MHC class Jb-restricted cell responses to Listeria monocytogenes infection.: Immunobiology. 1999 Dec;201(2):205-9. Unique Identifier : AIDSLINE MED/20097144; Kerksiek KM; Pamer EG; Section of Infectious Diseases, Yale University, New Haven,; Connecticut, USA.; Murine infection with Listeria monocytogenes induces CD8+ T cell responses specific for bacterial peptides that are presented on the infected cell surface by MHC class Ia and MHC class Ib molecules. We have used MHC tetramers to demonstrate that CD8+ T cells restricted by the H2-M3 MHC class Ib molecules constitute a
Genes, cells and cytokines in resistance against development of toxoplasmic encephalitis.: Immunobiology. 1999 Dec;201(2):255-71. Unique Identifier : AIDSLINE MED/20097150; Suzuki Y; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, CA, USA. ysuzuki@leland.stanford.edu; Toxplasma gondii is an intracellular protozoan parasite which invades various organs including the central nervous system. Immunity is crucial for preventing development of toxoplasmic encephalitis (TE) following infection. IFN-gamma-mediated immune response plays a central role in the resistance. The activation of mi
Chemokines and chemokine receptors in infectious diseases.: Immunol Cell Biol. 1999 Dec;77(6):469-75. Unique Identifier : AIDSLINE MED/20040260; Mahalingam S; Karupiah G; School of Human and Biomedical Sciences, Division of Science and; Design, University of Canberra, Australia.; mahaling@science.canberra.edu.au; Today, 10 years after the discovery of IL-8, chemokines (chemotactic cytokines) are seen as the stimuli that largely control leucocyte migration. Chemokines are low molecular weight chemoattractant cytokines secreted by a variety of cells, including leucocytes, epithelial cells, endothelial cells, fibroblasts and nume
Expression of interleukin-1 receptors in the later period of foetal thymic organ culture and during suspension culture of thymocytes from aged mice.: Immunol Cell Biol. 1999 Dec;77(6):491-8. Unique Identifier : AIDSLINE MED/20040263; Oh SH; Kim K; College of Pharmacy, Ewha Womans University, Seoul, Korea.; Interleukin-1 has been reported to be involved in thymocyte development by exerting a variety of effects on immature CD4-CD8- double-negative (DN) thymocytes. In contrast to the well-documented involvement of IL-1 in thymocyte development, expression of IL-1 receptors (IL-1R) on thymocytes has not been well demonstrat
The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo.: Immunol Cell Biol. 1999 Dec;77(6):539-43. Unique Identifier : AIDSLINE MED/20040269; Mintern J; Li M; Davey GM; Blanas E; Kurts C; Carbone FR; Heath WR; Immunology Division, The Walter and Eliza Hall Institute of; Medical Research, Melbourne, Victoria.; This report examines the use of 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE) to determine the site, duration and cell type responsible for antigen presentation in vivo. Evidence that CFSE-labelled T cells can be used to determine where various types of antigens are presented, including auto-antigen
Differential induction of chemokines in human microglia by type I and II interferons.: Glia. 2000 Feb 1;29(3):273-80. Unique Identifier : AIDSLINE MED/20111161; McManus CM; Liu JS; Hahn MT; Hua LL; Brosnan CF; Berman JW; Lee SC; Department of Pathology, Albert Einstein College of Medicine,; Bronx, New York 10461, USA.; Chemokines are secreted proteins that function as chemoattractants, mediating the recruitment of specific subsets of leukocytes to sites of tissue damage and immunological reactions. Chemokines may also function as antiviral agents, since viruses such as human immunodeficiency virus type 1 (HIV-1) use chemokine recept
Alteration of cytokine levels in murine retrovirus infection: modulation by combination therapy.: Int J Immunopharmacol. 1999 Dec;21(12):815-27. Unique Identifier : AIDSLINE MED/20072018; Bowden R; Tate SM; Soto S; Specter S; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa 33612, USA.; Immunoregulatory cytokines may regulate the resistance or susceptibility of a host to retroviral infection. These cytokines may be therapeutically modulated to prevent or limit the progression of infection. The non-progression to AIDS of some HIV+ patients has been related to a strong type 1 cytokine response (
[AIDS-free time and survival of an injecting drug users HIV seroconvertors cohort]: Gac Sanit. 1999 Sep-Oct;13(5):337-45. Unique Identifier : AIDSLINE MED/20033570; Perez-Hoyos S; Avino M; Hernandez I; Gonzalez J; Ruiz I; Institut Valencia d'Estudis en Salut Publica, Valencia, 46017,; Espana. sperez@san.gva.es; OBJECTIVE: To analyze AIDS free time, survival and the pre-AIDS survival for a injecting drug users cohort (IDU) of HIV seroconvertors. SUBJECT AND METHODS: Interval for seroconversion was available for 276 IDUs from Centers for AIDS Information and Prevention (CIPS) recruited between 1987 and until June of 1996. AIDS
Ras-induced transformation and signaling pathway.: J Biochem (Tokyo). 1999 Nov;126(5):799-803. Unique Identifier : AIDSLINE MED/20012985; Yamamoto T; Taya S; Kaibuchi K; Division of Signal Transduction, Nara Institute of Science and; Technology, Ikoma, Nara, 630-0101, Japan.; Ras is a signal-transducing, guanine nucleotide-binding protein for various membrane receptors including tyrosine kinase receptors. Ras participates in the regulation of cell proliferation, differentiation, and morphology. Activated ras oncogenes have been identified in various forms of human cancer including epitheli
Use of artificial neural networks in a QSAR study of anti-HIV activity for a large group of HEPT derivatives.: J Chem Inf Comput Sci. 2000 Jan-Feb;40(1):147-54. Unique Identifier : AIDSLINE MED/20125203; Jalali-Heravi M; Parastar F; Department of Chemistry, Sharif University of Technology, Tehran,; Iran.; Anti-HIV activity for a set of 107 inhibitors of the HIV-1 reverse transcriptase, derivatives of 1-[2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT), was modeled with the aid of chemometric techniques. The activity of these compounds was estimated by means of multiple linear regression (MLR) and artificial neural
Quantification of human polyomavirus JC in brain tissue and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy by competitive PCR.: J Virol Methods. 2000 Jan;84(1):23-36. Unique Identifier : AIDSLINE MED/20106900; Drews K; Bashir T; Dorries K; Institut fur Virologie und Immunbiologie der Julius-Maximilians; Universitat Wurzburg, Germany.; Activation of human polyomavirus JC (JCV) infection is the cause of the central nervous system (CNS) disease progressive multifocal leukoencephalopathy (PML). Previous studies with uncontrolled quantification systems suggested that the virus load in the CNS correlates with the state of disease and might reflect therap
A strategy for cloning infectious molecular clones of retroviruses from serum or plasma.: J Virol Methods. 2000 Jan;84(1):37-48. Unique Identifier : AIDSLINE MED/20106901; Holterman L; Dubbes R; Mullins J; Haaijman J; Heeney J; Department of Virology, Biomedical Primate Research Centre,; Rijswijk, The Netherlands.; To enable biological characterisation of lentiviral variants which emerge during infection and development of AIDS, a method was developed to construct molecular clones from circulating simian immunodeficiency virus (SIV) particles present in as little as 20 microl of serum from infected rhesus monkeys. This technique
In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses.: J Clin Microbiol. 2000 Jan;38(1):110-9. Unique Identifier : AIDSLINE MED/20085119; Piret J; Lamontagne J; Bestman-Smith J; Roy S; Gourde P; Desormeaux A; Omar RF; Juhasz J; Bergeron MG; Centre de Recherche en Infectiologie, Universite Laval, Ste-Foy,; Quebec, Canada G1V 4G2.; The efficacy of sodium lauryl sulfate (SLS), a sulfated anionic chaotropic surfactant, and dextran sulfate (DS), a polysulfated carbohydrate, against herpes simplex virus (HSV) and human immunodeficiency virus (HIV) infections was evaluated in cultured cells and in different murine models of HSV infection. Results sho
Recovery of Candida dubliniensis from non-human immunodeficiency virus-infected patients in Israel.: J Clin Microbiol. 2000 Jan;38(1):170-4. Unique Identifier : AIDSLINE MED/20085128; Polacheck I; Strahilevitz J; Sullivan D; Donnelly S; Salkin IF; Coleman DC; Department of Clinical Microbiology, The Hebrew; University-Hadassah Medical Center, Jerusalem, Israel.; Candida dubliniensis is a recently discovered yeast species principally associated with carriage and disease in the oral cavities of human immunodeficiency virus (HIV)-infected individuals. To date the majority of isolates of this species have been identified in Europe and North America. In this study, five Candida is
Performance of immunoblotting in diagnosis of visceral Leishmaniasis in human immunodeficiency virus-Leishmania sp.-coinfected patients.: J Clin Microbiol. 2000 Jan;38(1):175-8. Unique Identifier : AIDSLINE MED/20085129; Santos-Gomes G; Gomes-Pereira S; Campino L; Araujo MD; Abranches P; Unidade de Leishmanioses, Centro de Malaria e Outras Doencas; Tropicais, Instituto de Higiene e Medicina Tropical, Universidade; Nova de Lisboa, 1349-008 Lisbon, Portugal.; santosgomes@ihmt.unl.pt; This study evaluated the performance of immunoblotting with Leishmania infantum soluble antigens for the diagnosis of visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and immunocompetent patients and assessed the humoral responses of patients coinfected with HIV and Leishmania. In this work, the r
Optimized PCR using patient blood samples for diagnosis and follow-up of visceral Leishmaniasis, with special reference to AIDS patients.: J Clin Microbiol. 2000 Jan;38(1):236-40. Unique Identifier : AIDSLINE MED/20085139; Lachaud L; Dereure J; Chabbert E; Reynes J; Mauboussin JM; Oziol E; Dedet JP; Bastien P; Laboratoire de Parasitologie-Mycologie et Centre National de; Reference sur les Leishmanioses, Centre; Hospitalier-Universitaire, 34000 Montpellier, France.; We developed a highly sensitive PCR method that enables the diagnosis and posttherapeutic follow-up of visceral leishmaniasis with patient blood. The PCR assay was thoroughly optimized by successive procedural refinements to increase its sensitivity and specificity. It was compared to in vitro cultivation as well as t
Typing of Histoplasma capsulatum isolates based on nucleotide sequence variation in the internal transcribed spacer regions of rRNA genes.: J Clin Microbiol. 2000 Jan;38(1):241-5. Unique Identifier : AIDSLINE GENBANK/AF129547; Jiang B; Bartlett MS; Allen SD; Smith JW; Wheat LJ; Connolly PA; Lee CH; Department of Pathology, Indiana University School of Medicine,; Indianapolis, Indiana 46202, USA.; The nucleotide sequences of internal transcribed spacer (ITS) regions of rRNA genes of 24 isolates of Histoplasma capsulatum were examined. The results indicate that the sequences of ITS regions in different isolates are not identical. Sequence variations were found at 20 positions in the 496 bp that were sequenced. T
Recovery and analysis of human immunodeficiency virus type 1 (HIV) RNA sequences from plasma samples with low HIV RNA levels.: J Clin Microbiol. 2000 Jan;38(1):309-12. Unique Identifier : AIDSLINE MED/20085152; Niubo J; Li W; Henry K; Erice A; Department of Laboratory Medicine & Pathology, St. Paul,; Minnesota, USA.; Amplification of human immunodeficiency virus type 1 (HIV) reverse transcriptase (RT) and protease (PT) sequences from plasma is difficult when HIV RNA levels are low, and it usually cannot be accomplished in samples with
Stability of plasma human immunodeficiency virus load in VACUTAINER PPT plasma preparation tubes during overnight shipment.: J Clin Microbiol. 2000 Jan;38(1):323-6. Unique Identifier : AIDSLINE MED/20085155; Holodniy M; Rainen L; Herman S; Yen-Lieberman B; AIDS Research Center, VA Palo Alto Health Care System, Palo Alto,; California, USA.; VACUTAINER PPT plasma preparation tubes were evaluated to determine the effects of various handling and shipping conditions on plasma human immunodeficiency virus (HIV) load determinations. Plasmas obtained from PPT tubes stored and shipped under nine different conditions were compared to conventional EDTA tube plasma
Quantitation of human immunodeficiency virus type 1 group O load in plasma by measuring reverse transcriptase activity.: J Clin Microbiol. 2000 Jan;38(1):402-5. Unique Identifier : AIDSLINE GENBANK/AF081822; Lerma JG; Soriano V; Mas A; Quinones-Mateu ME; Arts EJ; Heneine W; HIV and Retrovirology Branch, Division of AIDS, TB Laboratory; Research, National Center for Infectious Diseases, Centers for; Disease Control and Prevention, Atlanta, Georgia, USA.; We have evaluated the use of an ultrasensitive reverse transcriptase (RT) activity assay to monitor plasma viremia in two human immunodeficiency virus type 1 (HIV-1) group O-infected patients treated with stavudine , lamivudine, and
Obtaining unacceptable results in assays for quantitation of human immunodeficiency virus type 1 RNA in plasma samples [letter]: J Clin Microbiol. 2000 Jan;38(1):472-3. Unique Identifier : AIDSLINE MED/20142714; Aguilera A; Vela A; Trevino M; Varela E; Seoane R; Regueiro BJ
Relationship of incremental specimen volumes and enhanced detection of human immunodeficiency virus type 1 RNA with nucleic acid amplification technology.: J Clin Microbiol. 2000 Jan;38(1):85-9. Unique Identifier : AIDSLINE MED/20085114; Witt DJ; Kemper M; Stead A; Ginocchio CC; Caliendo AM; Organon Teknika Corporation, Durham, North Carolina, USA.; dwitt@orgtek.com; The relationship between specimen input volume and the frequency of reported human immunodeficiency virus type 1 (HIV-1) RNA copy numbers by nucleic acid amplification technology (the NASBA HIV-1 RNA QT system) was investigated. Results obtained with both clinical specimens and dilution panels indicated that both the
Clinicopathologic analysis of 124 cases of adult T-cell leukemia/lymphoma with cutaneous manifestations: the smouldering type with skin manifestations has a poorer prognosis than previously thought.: J Dermatol. 1999 Dec;26(12):785-90. Unique Identifier : AIDSLINE MED/20124723; Setoyama M; Katahira Y; Kanzaki T; Department of Dermatology, Faculty of Medicine, Kagoshima; University, Japan.; Adult T-cell leukemia/lymphoma (ATLL) commonly involves the skin as well as peripheral blood and lymph nodes. During the last 15 years we have studied 124 cases of ATLL with specific skin manifestations. Twenty-one patients (16.9%) were classified as acute, 21 (16.9%) as chronic, 26 (21.0%) as lymphoma, and 56 (45.2%)
Characterization of infiltrating T cells in human scalp explants from alopecia areata to SCID nude mice: possible role of the disappearance of CD8+ T lymphocytes in the process of hair regrowth.: J Dermatol. 1999 Dec;26(12):797-802. Unique Identifier : AIDSLINE MED/20124725; Tsuboi H; Tanei R; Fujimura T; Ohta Y; Katsuoka K; Department of Dermatology, Kitasato University School of; Medicine, Sagamihara, Japan.; T cells may play a role in the pathogenesis of alopecia areata (AA). We attempted to elucidate the linkage between infiltrating T cells and hair regrowth processes by grafting scalp skin from the affected region of patients with AA onto severe combined immune deficiency (SCID) nude mice. When the AA scalp was grafted
Atlas of brain proton magnetic resonance spectra. Part III: Viral infections.: J Neuroradiol. 1999 Oct;26(3):154-61. Unique Identifier : AIDSLINE MED/20121124; Salvan AM; Confort-Gouny S; Cozzone PJ; Vion-Dury J; Centre de Resonance Magnetique Biologique et Medicale (CRMBM),; UMR CNRS 6612, Faculte de Medecine de Marseille, France.
Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions.: J Pathol. 1999 May;188(1):76-81. Unique Identifier : AIDSLINE MED/99359575; Taraboletti G; Benelli R; Borsotti P; Rusnati M; Presta M; Giavazzi R; Ruco L; Albini A; Department of Oncology, Mario Negri Institute for Pharmacological; Research, 24125 Bergamo, Italy. taraboletti@irfmn.mnegri.it; Kaposi s sarcoma (KS), a neoplasm often associated with iatrogenic and acquired immunosuppression, is characterized by prominent angiogenesis. Angiogenic factors released by both KS and host cells, as well as HHV-8 and HIV viral products, have been implicated in the pathogenesis of this lesion. Angiogenesis is the res
Survival of patients with HTLV-I-associated lymph node lesions.: J Pathol. 1999 Dec;189(4):539-45. Unique Identifier : AIDSLINE MED/20096938; Ohshima K; Suzumiya J; Sato K; Kanda M; Simazaki T; Kawasaki C; Haraoka S; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Fukuoka, Japan.; Adult T-cell leukaemia/lymphoma (ATLL), is a malignant condition associated with human T-cell leukaemia virus type I (HTLV-I). Usually, although not uniformly, histopathological examination of the lymph nodes shows a pleomorphic type. In addition, some patients with pre-overt ATLL show a Hodgkin s disease-like morphol
Cytomegalovirus infection and HIV-I disease progression in infants born to HIV-I-infected women.: J Pediatr. 2000 Jan;136(1):125. Unique Identifier : AIDSLINE MED/20142728; Fowler SL; Medical University of South Carolina, Charleston 29425, USA.
Inhibition of HIV-1 entry before gp41 folds into its fusion-active conformation.: Unique Identifier : AIDSLINE MED/20090923; Kliger Y; Shai Y; HIV-1 entry into its host cell is modulated by its transmembrane envelope glycoprotein (gp41). The core of the activated conformation of gp41 consists of a trimer of heterodimers comprising a leucine/isoleucine zipper sequence (represented here by the synthetic peptide N36 or by the longer N51 peptide) and a C-termina
An ancient nation braces to fight AIDS [news]: JAMA. 2000 Feb 2;283(5):593-5. Unique Identifier : AIDSLINE MED/20127452; Voelker R
Cytomegalovirus retinitis in the era of highly active antiretroviral therapy [clinical conference]: JAMA. 2000 Feb 2;283(5):653-7. Unique Identifier : AIDSLINE MED/20127472; Whitcup SM; Clinical Branch, National Eye Institute, National Institutes of; Health, Bethesda, MD 20892-1863, USA. whitcup_scott@allergan.com; A number of striking changes have occurred recently in the presentation and course of cytomegalovirus ( CMV ) retinitis in patients with acquired immunodeficiency syndrome (AIDS) who are receiving highly active antiretroviral t
Immune function did not decline with aging in apparently healthy, well-nourished women.: Mech Ageing Dev. 1999 Dec 7;112(1):43-57. Unique Identifier : AIDSLINE MED/20119959; Krause D; Mastro AM; Handte G; Smiciklas-Wright H; Miles MP; Ahluwalia N; Nutrition Department, The Pennsylvania State University,; University Park 16802, USA.; Nutrition plays a crucial role in immune function. Most studies on age-associated changes in immunocompetence in healthy adults did not examine the nutritional status of participants extensively. Inadequate nutritional status may confound the relationship of aging and immune response. The purpose of this study was to
Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children.: Lancet. 2000 Jan 29;355(9201):369-73. Unique Identifier : AIDSLINE MED/20127323; Graham SM; Mtitimila EI; Kamanga HS; Walsh AL; Hart CA; Molyneux ME; Department of Paediatrics, College of Medicine, University of; Malawi, Blantyre. smgraham@liverpool.ac.uk; BACKGROUND: Necropsy studies from Africa have shown that Pneumocystis carinii pneumonia (PCP) is common in infants with HIV infection. We aimed to describe the rate, clinical presentation, and outcome of PCP in young Malawian children with acute severe pneumonia. METHODS: Children aged between 2 months and 5 years who
Condoms and seat belts: the parallels and the lessons.: Lancet. 2000 Jan 29;355(9201):400-3. Unique Identifier : AIDSLINE MED/20127337; Richens J; Imrie J; Copas A; Department of Sexually Transmitted Diseases, Royal Free and; University College Medical School, The Mortimer Market Centre,; London, UK. jrichens@gum.ucl.ac.uk
Role of Th1 and Th2 cytokines in regulating the liver injury induced by delayed-type hypersensitivity to picryl chloride.: Liver. 1999 Dec;19(6):473-80. Unique Identifier : AIDSLINE MED/20125322; Xu Q; Cao J; Wu F; Hayakawa Y; Saiki I; Koda A; Department of Pharmacology for Chinese Materia Medica, China; Pharmaceutical University, Nanjing.; AIMS/BACKGROUND: We have previously reported that a new model of liver injury induced in mice by delayed-type hypersensitivity (DTH) to picryl chloride (PCl) mimicks the pathogenesis of human hepatitis. This liver injury is mediated by CD4+ T cells. The interaction between lymphocyte function associated antigen 1 (LFA
Infected physicians and invasive procedures: national policy and legal reality.: Milbank Q. 1999;77(4):511-29, iii. Unique Identifier : AIDSLINE MED/20121484; Tereskerz PM; Pearson RD; Jagger J; International Health Care Worker Safety Center, Charlottesville,; VA 22903, USA. pjm7s@virginia.edu; Recent reports of the transmission of hepatitis B, hepatitis C, and HIV from physicians to patients during invasive procedures have again raised the question of whether physicians infected with bloodborne pathogens should perform invasive procedures that place patients at risk, and if so, under what conditions. Attemp
[Immunodominant epitope of HIV-1 gp120 protein forms double beta fold in a solution]: Mol Biol (Mosk). 1999 Jul-Aug;33(4):605-10. Unique Identifier : AIDSLINE MED/20013536; Andrianov AM
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions.: Mol Cell Biol. 2000 Feb;20(3):1063-71. Unique Identifier : AIDSLINE MED/20094985; Liu HX; Chew SL; Cartegni L; Zhang MQ; Krainer AR; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York; 11724-2208, USA.; Exonic splicing enhancers (ESEs) are important cis elements required for exon inclusion. Using an in vitro functional selection and amplification procedure, we have identified a novel ESE motif recognized by the human SR protein SC35 under splicing conditions. The selected sequences are functional and specific: they p
Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells.: Mol Cell Biol. 2000 Feb;20(3):936-46. Unique Identifier : AIDSLINE MED/20094973; Merritt C; Enslen H; Diehl N; Conze D; Davis RJ; Rincon M; Immunobiology Program, Department of Medicine, University of; Vermont, Burlington, Vermont 05405, USA.; CD4(+) and CD8(+) T cells play specific roles during an immune response. Different molecular mechanisms could regulate the proliferation, death, and effector functions of these two subsets of T cells. The p38 mitogen-activated protein (MAP) kinase pathway is induced by cytokines and environmental stress and has been a
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.: Mol Cell Biol. 2000 Feb;20(3):947-56. Unique Identifier : AIDSLINE MED/20094974; Chen M; Cheng A; Candotti F; Zhou YJ; Hymel A; Fasth A; Notarangelo LD; O'Shea JJ; Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch,; National Institute of Arthritis, Musculoskeletal and Skin; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA. chenm@arb.niams.nih.gov; The structure of Janus kinases (JAKs) is unique among protein tyrosine kinases in having tandem, nonidentical kinase and pseudokinase domains. Despite its conservation in evolution, however, the function of the pseudokinase domain remains poorly understood. Lack of JAK3 expression results in severe combined immunodefi
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.: Mol Cell Biol. 2000 Feb;20(4):1170-8. Unique Identifier : AIDSLINE MED/20115862; O'Mahony A; Lin X; Geleziunas R; Greene WC; Gladstone Institute of Virology and Immunology, Microbiology and; Immunology, University of California, San Francisco, California; 94141, USA.; Signal-induced nuclear expression of the eukaryotic NF-kappaB transcription factor involves the stimulatory action of select mitogen-activated protein kinase kinase kinases on the IkappaB kinases (IKKalpha and IKKbeta) which reside in a macromolecular signaling complex termed the signalsome. While genetic studies indi
Virostatic therapy for advanced lymphoproliferation associated with the Epstein-Barr virus in an HIV-infected patient [letter]: N Engl J Med. 2000 Feb 10;342(6):440-1. Unique Identifier : AIDSLINE MED/20116968; Schmidt W; Anagnostopoulos I; Scherubl H
KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement.: Nature. 2000 Jan 20;403(6767):325-8. Unique Identifier : AIDSLINE MED/20123249; Huard B; Karlsson L; The R.W. Johnson Pharmaceutical Research Institute, San Diego,; California 92121, USA. huard@cmu.unige.ch; Natural killer cell tolerance is maintained by the interaction of killer inhibitory receptors (KIRs) with self-major histocompatibility complex class I gene products. A subset of T cells also expresses inhibitory receptors, but the functional significance of these receptors on T cells is unclear. Here we show that, in
Seroprevalence of HIV-1 subtypes A-E among HIV-1 infected individuals from Slovenia.: Pflugers Arch. 2000;439(3 Suppl):R45-6. Unique Identifier : AIDSLINE MED/20116839; Poljak M; Seme K; Marin IJ; Tomazic J; Vidmar L; Maticic M; Kasper P; Institute of Microbiology and Immunology, Medical Faculty,; Ljubljana, Slovenia.; To investigate the prevalence of HIV-1 subtypes A-E in Slovenia , 82 HIV-1 infected individuals were tested for the presence of HIV-1 subtype specific antibodies using a research competitive peptide enzyme immuno assay supplied by Boehringer Mannheim. In 74 individuals unambiguous
Western governments must promote the development of indigenous anti-HIV drugs.: Nurs Times. 1999 Sep 8-14;95(36):43. Unique Identifier : AIDSLINE MED/20127105; Waterworth C; Chelsea and Westminster Hospital, London.
Awareness effect on nursing students of planned teaching programmes on AIDS.: Nurs J India. 1998 Jun;89(6):128-9, 138. Unique Identifier : AIDSLINE MED/20135271; Kaur J; G.M. Hospital, Nawan Shahar, Punjab.
Human herpesvirus 8-associated solid lymphomas that occur in AIDS patients take anaplastic large cell morphology.: Mod Pathol. 2000 Jan;13(1):77-85. Unique Identifier : AIDSLINE MED/20122023; Katano H; Suda T; Morishita Y; Yamamoto K; Hoshino Y; Nakamura K; Tachikawa N; Sata T; Hamaguchi H; Iwamoto A; Mori S; Department of Pathology, Institute of Medical Science, University; of Tokyo, Japan. katano@nih.go.jp; Human herpesvirus type 8 (HHV-8; Kaposi s sarcoma-associated herpesvirus) is a recently isolated human herpesvirus frequently identified in Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman s disease. Here we report three cases of HHV-8-bearing solid lymphomas that occurred in AIDS patients (Case
Significance testing of clinical data using virus dynamics models with a Markov chain Monte Carlo method: application to emergence of lamivudine-resistant hepatitis B virus.: Proc R Soc Lond B Biol Sci. 1999 Dec 7;266(1436):2359-66. Unique Identifier : AIDSLINE MED/20107693; Burroughs NJ; Pillay D; Mutimer D; Mathematics Institute, University of Warwick, Coventry, UK.; njb@maths.warwick.ac.uk; Bayesian analysis using a virus dynamics model is demonstrated to facilitate hypothesis testing of patterns in clinical time-series. Our Markov chain Monte Carlo implementation demonstrates that the viraemia time-series observed in two sets of hepatitis B patients on antiviral (lamivudine) therapy, chronic carriers an
Increased CD4+CD16+ and CD4+CD56+ T cell subsets in Behcet's disease.: Rheumatol Int. 1999;19(1-2):23-6. Unique Identifier : AIDSLINE MED/20114499; Eksioglu-Demiralp E; Direskeneli H; Ergun T; Fresko I; Akoglu T; Kosuyolu Cad, Kadikoy, Istanbul, Turkey. demiralp@marun.edu.tr; Behcet s disease is a systemic vasculitis of unknown etiology. Various immune abnormalities have previously been shown in Behcet s disease. We investigated T lymphocyte subsets associated with cytotoxic activity and natural killer (NK) cells by flow cytometry in 37 patients with Behcet s disease, 38 healthy controls,
Illness narratives: time, hope and HIV.: Soc Sci Med. 2000 Mar;50(5):605-17. Unique Identifier : AIDSLINE MED/20121952; Ezzy D; Sociology, University of Tasmania, Hobart, Australia.; douglas.ezzy@utas.edu.au; Life threatening illness, such as HIV/AIDS, also threaten people s sense of identity and taken-for-granted assumptions about the temporal framing of their lives. In response, people often experience transformations in values, spirituality and life priorities. Drawing on a combined quantitative and qualitative study of
Highway cowboys, old hands, and Christian truckers: risk behavior for human immunodeficiency virus infection among long-haul truckers in Florida.: Soc Sci Med. 2000 Mar;50(5):737-49. Unique Identifier : AIDSLINE MED/20121963; Stratford D; Ellerbrock TV; Akins JK; Hall HL; Department of Anthropology, University of Florida, Gainesville; 32607, USA. bbs8@cdc.gov; This paper reports the results of ethnographic research to describe risk for human immunodeficiency virus (HIV) infection among long-haul truck drivers and the contexts and factors that influence risk and protective behaviors. Drivers were selected using purposive and snowball sampling at trucking-related businesses a
Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment.: Unique Identifier : AIDSLINE MED/20076676; Hnizdo E; Singh T; Churchyard G; BACKGROUND: A study was undertaken to establish the chronic effect of initial and recurrent treated pulmonary tuberculosis on impairment of lung function. METHODS: A total of 27 660 black South African gold miners who had reliable pulmonary function tests from January 1995 to August 1996 were retrospectively followed
A case of type 2B von Willebrand disease reverse to normal when treated with high doses of protease inhibitor [letter]: Thromb Haemost. 1999 Nov;82(5):1558-9. Unique Identifier : AIDSLINE MED/20061107; Arkel YS; Ku DH; Lake C; Pasquale L; Lam X; Gibson D; Burstin S
Evidence for antiphospholipid antibodies in hemophilic children with factor VIII inhibitors. Recombinate PUP Study Group [letter]: Thromb Haemost. 1999 Nov;82(5):1559-60. Unique Identifier : AIDSLINE MED/20061108; Nuss R; Jacobson L; Hathaway WE; Manco-Johnson M
Lead intoxication impairs the generation of a delayed type hypersensitivity response.: Toxicology. 1999 Dec 6;139(3):255-64. Unique Identifier : AIDSLINE MED/20112451; McCabe MJ Jr; Singh KP; Reiners JJ Jr; Institute of Chemical Toxicology, Wayne State University,; Detroit, MI 48201, USA. m.j.mccabe.jr@wayne.edu; The effect of oral administration of lead, as Pb-acetate, via the drinking water on the murine delayed type hypersensitivity (DTH) response was investigated. The DTH response of BALB/c mice sensitized intravenously with sheep red blood cells (SRBC) was found to be suppressed markedly in lead-intoxicated mice. Suppress
Enhancement of susceptibility to Fas-mediated apoptosis of TH1 cells by nonmitogenic anti-CD3epsilon F(ab')2.: Transplantation. 2000 Jan 15;69(1):104-12. Unique Identifier : AIDSLINE MED/20117113; Yu XZ; Anasetti C; Division of Clinical Research, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.; BACKGROUND: Anti-CD3epsilon F(ab )2 are nonmitogenic for naive T cells but can induce apoptosis of antigen-activated T cells in vitro and in vivo. We studied the mechanisms by which nonmitogenic anti-CD3epsilon F(ab )2 antibodies induce T cell death. METHODS: OVA-responsive T cell lines were generated by immunization
Infections with flaviviridae.: Verh K Acad Geneeskd Belg. 1999;61(6):661-97; discussion 697-9. Unique Identifier : AIDSLINE MED/20121229; Neyts J; Leyssen P; De Clercq E; Rega Institute for Medical Research, KULeuven.; The family of the Flaviviridae contains 3 genera: (i) the hepaciviruses, to which belongs Hepatitis C virus (HCV), (ii) the flaviviruses and (iii) the pestiviruses. Over 140 million people, more than four times the number of HIV-positive individuals, are chronically infected with the HCV. Hepatitis G virus (HGV) has n
Human immunodeficiency virus infection: in situ polymerase chain reaction localization in human placentas after in utero and in vitro infection.: Am J Obstet Gynecol. 2000 Jan;182(1 Pt 1):207-13. Unique Identifier : AIDSLINE MED/20114964; Sheikh AU; Polliotti BM; Miller RK; Departments of Obstetrics and Gynecology and Environmental; Medicine, University of Rochester Medical Center, NY 14642-8668,; USA.; OBJECTIVE: We compared localization of human immunodeficiency virus type 1 within human placentas infected in utero with localization within human placental explants infected in vitro. STUDY DESIGN: Placental tissues from 3 cases of vertical transmission of human immunodeficiency virus type 1 were studied. Human place
Accidental injuries by HIV-contaminated instruments in health provider or research environments: can seroconversion be prevented?: Am Surg. 2000 Jan;66(1):14-21. Unique Identifier : AIDSLINE MED/20114763; Fokin AA; Robicsek F; Masters TN; Department of Thoracic and Cardiovascular Surgery, Carolinas; Medical Center, Charlotte, North Carolina 28203, USA.; The rate of seroconversion from percutaneous needlestick exposure to HIV infection is approximately 0.3 per cent. To investigate the possibility of local confinement of HIV, 100 to 200 nm Tc-99m sulfur colloid particles were injected in the canine model subcutaneously at the knee level and collected proximally at the
The case for more cautious, patient-focused antiretroviral therapy [see comments]: Ann Intern Med. 2000 Feb 15;132(4):306-11. Unique Identifier : AIDSLINE MED/20132335; Henry K; HIV Program, Regions Hospital and the University of Minnesota,; St. Paul 55101, USA. keithh6680@aol.com; Many clinicians who care for patients with HIV infection are dissatisfied with the existing recommendations on antiretroviral therapy. Current practice focuses on the early suppression of viremia, yet the outcome of that approach may not be in the best interest of individual patients or populations. The major goal of
Antiretroviral therapy: time to think strategically [editorial; comment]: Ann Intern Med. 2000 Feb 15;132(4):320-2. Unique Identifier : AIDSLINE MED/20132337; Cohen OJ
Protease inhibitors do not interfere with prohormone processing [letter]: Ann Intern Med. 2000 Feb 15;132(4):330. Unique Identifier : AIDSLINE MED/20132348; Danoff A; Ling WL
Epstein-Barr virus (EBV)-induced long-term proliferation of CD4+ lymphocytes leading to T lymphoblastoid cell lines carrying EBV.: Anticancer Res. 1999 Jul-Aug;19(4B):3007-17. Unique Identifier : AIDSLINE MED/20118178; Guan M; Romano G; Henderson EE; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, Pennsylvania 19140, USA.; We have previously demonstrated that Epstein-Barr virus (EBV) strain B95.8 can infect and initiate a partial transcriptional program in both CD4+ and CD8+ lymphocytes (Guan, M. X., R.-D. Zhang, B. Wu, and E. E. Henderson. 1996. J. Virol. 70:7341-7346). Experiments were undertaken to determine whether EBV infection can
Colorectal Kaposi's sarcoma in an HIV-negative male in association with ulcerative rectocolitis: a case report.: Anticancer Res. 1999 Jul-Aug;19(4B):3045-8. Unique Identifier : AIDSLINE MED/20118183; Tedesco M; Benevolo M; Frezza F; Mancini R; Carone MD; Mottolese M; Cosimelli M; First Department of Surgical Oncology, Regina Elena Cancer; Institute, Rome, Italy.; A rare case and the first reported in Italy of a classic form of colorectal Kaposi s sarcoma, associated with ulcerative rectocolitis, is presented. Following a total proctocolectomy, the patient was disease-free at four years. Some epidemiological risk factors such as sex, age, pla
Current understanding of AIDS pathogenesis.: Anticancer Res. 1999 Jul-Aug;19(4B):3157-66. Unique Identifier : AIDSLINE MED/20118199; Romano G; Kasten M; Giordano A; Kimmel Cancer Institute, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, PA 19107, USA.; From the mid 1990s, considerable progress has been achieved in understanding the biology of the human immunodeficiency virus type 1 (HIV-1), and the pathogenesis of the acquired immunodeficiency syndrome (AIDS). However, these achievements are still not sufficient to indicate the reasons for failure of the host immune
Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine.: Unique Identifier : AIDSLINE MED/20127255; Nath A; Haughey NJ; Jones M; Anderson C; Bell JE; Geiger JD; Department of Neurology, University of Kentucky, Lexington; 40536-0284, USA.; Human immunodeficiency virus type 1 (HIV-1) proteins Tat and gp120 have been implicated in the pathogenesis of dementia associated with HIV infection. Recently, we showed the presence of Tat protein in brains of patients with HIV-1 encephalitis as well as macaques with encephalitis
[The status of and outlook for the creation of new preparations for the therapy and prevention of HIV infection and AIDS]: Antibiot Khimioter. 1999;44(10):39-45. Unique Identifier : AIDSLINE MED/20101338; Ivanitskaia LP; Nosik DN; Bibikova MV; Iakushkina NI; Spiridonova IA; Grigor'ev VB; Lobach OA; National Research Centre of Antibiotics, Moscow.
A double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms.: Arch Gen Psychiatry. 2000 Feb;57(2):141-7; discussion 155-6. Unique Identifier : AIDSLINE MED/20127382; Rabkin JG; Wagner GJ; Rabkin R; New York State Psychiatric Institute, Department of Psychiatry,; College of Physicians and Surgeons, Columbia University, New York; 10032, USA. jgr1@Columbia.edu; BACKGROUND: The goal was to evaluate the efficacy of testosterone in alleviation of hypogonadal symptoms (diminished libido, depressed mood, low energy, and depleted muscle mass) in men with symptomatic human immunodeficiency virus illness. METHODS: Seventy-four patients were enrolled in a double-blind, placebo-controh
Prevalence and outcome of tuberculosis in patients with Hodgkin's disease.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 024). Unique Identifier : AIDSLINE AIDS/20710001; Portugal R; Cottas H; Ficks M; Nucci M; Spector N; University Hospital,Universidade Federal do Rio de Janeiro,; Brazil.; Objective: We undertook this study to ascertain the prevalence and characteristics of tuberculosis (TB) in our patients with Hodgkin s disease (HD). Methods: The study was a retrospective analysis of 98 patients with HD treated at University Hospital, Universidade Federal do Rio de Janeiro between 1980 and 1994. Tuberh
Reduction in incidence of O.I., hospitalizations and death rate with protease inhibitors combined with hirt, from 1995 to 1997 in CITAID, Mexico City.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 034). Unique Identifier : AIDSLINE AIDS/20710002; Alvardo DR; Feregrino GM; Ruiz CO; Gomez CW; Mireles VM; Higuera RF; Center for Research and Advanced Treatment in Immunocompromised; Host, Citaid, Mexico City.; OBJECTIVES: To compare end year cross sectional results in evolution of adults HIV/AIDS treated in CITAID in 1995, 1996, and 1997, for effect of better control with viral load and new antivirals combination as P.I. METHODS: Cross sectional styudy with ANOVA analisis of cross sectional end year results of evolut of HIVh
ITSs nested PCR for non invasive diagnosis of pneumocystis carinii pneumonia (PCP) in HIV+ children.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 035). Unique Identifier : AIDSLINE AIDS/20710003; Atzori C; Angeli E; Agostoni F; Mainini A; Micheli V; Cargnel A; Department of Infectious Diseases, Sacco Hospital-Milan, Italy.; Objective: To evaluate the possible application of ITSs nested PCR for non invasive diagnosis of PCP in HIV+ children with respiratory disease. Material and methods: We analyzed by ITSs nested PCR 81 biological samples (25 sera, 26 PBMC, 27 garglings, 2 induced sputa and 1 BAL) from 12 HIV+ children with pulmonary invh
Chemokine, chemokine receptor, cytokine and monokine levels in HIV-1-infected patients with CD4+ T lymphocytes of 200/cubic mm.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 036). Unique Identifier : AIDSLINE AIDS/20710004; Benveniste O; Dereuddre-Bosque N; Clayette P; Leport C; Vilde JL; Dormont D; Service de Neurovirologie, Fontenay aux Roses, France.; Objectives: to look for possible correlations of cytokines (CK), monokines (MK), chemokines (CHK) and chemokine receptors (CHK-R) with viral loads in HIV-1 infected patients. Design: Prospective, pilot study on 9 patients (4 CDC stage B & 5 stage C) where these parameters were measured repeatedly. Patients and meth
Comparison of the immune state of HIV-infected persons and acute radiations syndrom reconvalescents.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 037). Unique Identifier : AIDSLINE AIDS/20710005; Chumak A; Zahynayko V; Research Centre of Radiation Medicine, Kiev, Ukraine.; Objective: Immune states of 138 HIV-infected persons and 98 reconvalescents of 1986 acute radiation syndrom (ARS) as a result of Chernobyl Power Plant accident were compared. Methods: immunocompetent cells were quantified by flow cytometry. Anti-HIV 1/2, anti-hepatitis C virus antibody titer and HBs-antigen positivity
Rhodococcus equi infections in AIDS.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 038). Unique Identifier : AIDSLINE AIDS/20710006; Abati C; Ruga E; Meneghetti F; D'Elia R; Division of Infectious Diseases, University of Padova, Italy.; Rhodococcus equi is being reported as the cause of various infections, above all pneumonia, with increasing frequency in immunocompromised patients, specially those with HIV infections. In Veneto Region (nearly 5 millions of people), in Italy , no case of R. equi infection has been r
Benefits of IL-2 (1.8 MUIsc) bimonthly in HIV+ with very low viral load for A.V. treatment, and single doses of thalidomide, ketoprofen, or aspirin. Two years open label.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 039). Unique Identifier : AIDSLINE AIDS/20710007; Feregrino M; Gomez W; Alvarado DR; Mireles P; Ruiz CO; Citaid, Mexico.; 1.-INTRODUCTION-OBJECTIVES. There are many clinical trials worldwide with large, medium or low intermmitent doses of IL2 in stable HIV pat. mostly with clinical benefits but side effects in large doses. These open label clinical trial use 1.8 MUI sc 3 days/8 weeks in stable HIV pat. with effective reduction below 1000
CD8+ lymphocyte-mediated suppression of human immunodeficiency virus type 1 expression in human brain cells.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 040). Unique Identifier : AIDSLINE AIDS/20710008; Gekker G; Lokensgard JR; Hu S; Chao CC; Simpson M; Schut RL; Peterson PK; Institute for Brain and Immune Disorders, Minneapolis, MN.; Objective: to test the hypothesis that CD8+ lymphocytes from infected patients, but not from uninfected subjects, would suppress HIV-1 expression in human brain cells. Results: using human glial/neuronal cell cultures, CD8+ lymphocytes from six of seven asymptomatic, infected patients significantly inhibited HIV-1 exp
Sharp rising trend of HIV seropositivity in the pink city-Jaipur.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 041). Unique Identifier : AIDSLINE AIDS/20710009; Guleri AS; Saxena K; Maheshwari RK; Sharma A; Department of Microbiology & Immunology, Sawai Man Singh Medical; College, Jaipur, India.; The HIV Surveillance centre housed in this department has tested 21834 serum samples for HIV antibodies between 1987 and January 1998. Category of subjects includes: STD patients, foreign students, indoor patients with suspected AIDS from the SMS and attached group of hospitals, antenatal mothers, blood donors, etc. 3
Colonization and infection with S. aureus in HIV-infected patients (pt).: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 042). Unique Identifier : AIDSLINE AIDS/20710010; Nguyen MH; Kauffman CA; Goodman RP; Squier C; Arbeit RD; Singh N; Wagener M; Yu VL; Veterans Affairs Medical Center, Pittsburgh, PA.; S. aureus infection is increasingly described in pt with advanced AIDS. We prospectively studied HIV-infected pt at 3 VA medical centers to assess S. aureus nasal carriage and risk of infection. A total of 231 pt had cultures performed every 3 mo. For 2 yr. For the 201 pt who had >/= 3 cultures done, 26 (13%) were per
Effect of switch from single to double protease inhibitor-containing highly active antiretroviral therapy (HAART).: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 043). Unique Identifier : AIDSLINE AIDS/20710011; Kaufmann D; Battegay M; Kaiser L; Chave JP; Telenti A; Telenti A; Background: HAART including two protease inhibitors (2xPI), Ritonavir or Nelfinavir with Saquinavir is an alternative to 1xPI. The impact and potential benefit of such modification on viremia and CD
Epidemiology of drug resistance in streptococcus pneumoniae isolates in AIDS.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 044). Unique Identifier : AIDSLINE AIDS/20710012; Mastroianni A; Coronado O; Cancellieri C; Nanetti A; Montini G; Manfredi R; Chiodo F; Divisione di Malattie Infettive, Ospedale G.B. Morgagni, Forli,; Italy.; Objective: To verify the emergence of infections caused by Streptococcus pneumoniae with decreased susceptibility to antibiotics in patients (pts) with HIV disease attending two large infectious diseases units. Methods: We have performed a retrospective review of the records of all hospitalized pts from whom pneumococ
Flavobacterium meningosepticum septicemia in AIDS.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 045). Unique Identifier : AIDSLINE AIDS/20710013; Coronado O; Mastroianni A; Nanetti A; Manfredi R; Chiodo F; Istituto Malattie Infettive, Universita di Bologna, Forli, Italy.; Objective: We report the first cases of non catheters-related community-acquired sepsis (CAS) due to F. meningosepticum in patients (pts) with AIDS. Case Reports: We recently encountered three cases of CAS with isolates of F. meningosepticum in pts with AIDS. Both pts developed a clinical sepsis non related with the u
Prevalence and factors associated with perianal ulcer in AIDS patients.: Unique Identifier : AIDSLINE AIDS/20710014; Nascimento MC; Pannuti CS; Nascimento CM; Elufi Neto J; Objectives: To determine the prevalence of perianal ulceration in AIDS patients who were hospitalized for treatment of AIDS associated diseases and to investigate factors associated with the presence of the lesion. Methods: Between October/96 and June/97, 272 AIDS patients who were hospitalized for treatment of variou
Paracoccidioidomycosis (PCM) associated with acquired immunodeficiency syndrome (AIDS).: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 047). Unique Identifier : AIDSLINE AIDS/20710015; Nouer SA; Almeida VC; Aoki FH; Branchini ML; Papaiordanou PM; University Hospital,Universidade Estadual de Campinas, Sao Paulo,; Brazil.; Introduction: PCM has not been regarded as an infection usually associated with immunossuppresion. In Brazil , the association between PCM and AIDS is particularly important because of the progressive dissemination of HIV to small and medium urban centers, areas of high prevalence o
Detection of candida dubliniensis isolates in oropharyngeal candidiasis in HIV-infected patients.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 048). Unique Identifier : AIDSLINE AIDS/20710016; Patterson TF; Kirkpatrick WR; McAtee RK; Lopez-Ribot JL; Fothergill AW; Patterson JE; Sutton DA; Rinaldi MG; University of Texas Health Science Center, San Antonio, TX.; OBJECTIVE: The presence of C. dubliniensis isolates was assessed in HIV-infected patients prospectively evaluated for recurrent thrush in order to determine the prevalence and antifungal susceptibility of these yeasts in a cohort of patients from North America. METHODS: A longi
Bactericidal action of ampicillin/sulbactam against four potentially-pathogenic mycobacteria.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 049). Unique Identifier : AIDSLINE AIDS/20710017; Prabhakaran K; Harris EB; Randhawa B; GWL HD Center at Louisiana State University, Baton Rouge, LA.; Objective: No specific drugs are available at present for the treatment of infections caused by potentially-pathogenic saprophytic mycobacteria in immuno-compromised subjects. Beta-Lactam antibiotics are the most widely-used antimicrobial agents; since mycobacteria synthesize beta-lactamase, these antibiotics are inef
Mytcobacterium avium intracellulare complex infection in HIV infected children: severe gastrointestinal localization.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 050). Unique Identifier : AIDSLINE AIDS/20710018; Ruga E; Giaquinto C; Rampon O; Giacomet V; Cozzani S; D'Elia R; Department of Infectious Diseases on Immunocompromised Host,; University of Padova, Italy.; Objective: To describe the clinical pattern of Mycobacterium avium intracellulare complex (MAC) infection in HIV infected children. Method: The medical records of 92 HIV infants and children less than 14 years old, followed at the Department of Paediatrics of the University of Padova between January 1985 and January 1
Extraintestinal microsporidial infection in a boy with AIDS. Failure of radical cure with albendazole.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 051). Unique Identifier : AIDSLINE AIDS/20710019; Caselli D; Maccabruni A; Gatti S; Sacchi L; Bernuzzi AM; Corona S; Scaglia M; Institute of Infectious Diseases, University-IRCCS S. Matteo,; Pavia, Italy.; Objective: To describe a case of microsporidiosis in an AIDS-boy treated with albendazole without parasitological cure. Case-report: An Italian boy, HIV pos at the birth (1985), at 6 years of age developed a lymphnodal Burkitt-like lymphoma that recovered after cycles
Comparison of pneumocystis carinii pneumonia (PCP) in HIV-positive and HIV-negative immunocompromized patients.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 052). Unique Identifier : AIDSLINE AIDS/20710020; Bellini C; Nuesch R; Zimmerli W; Division of Infectious Diseases, University Hospitals, Basel,; Switzerland.; Objective: PCP is decreasing in AIDS-patients, but increasing in severely immunocompromized HIV-negative individuals. We compared the clinical picture and prognosis of PCP in HIV-positive and HIV-negative patients. Method: From 1983-95, 103 patients were treated for PCP at our institution. 92 records, 75 from HIV-posi
The effect of dimethyl sufoxide (DMSO) on activation of the major immediate early promoter of human cytomegalovirus.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 058). Unique Identifier : AIDSLINE AIDS/20710021; He B; Monick M; Hunninghake G; Division of Pulmonary of Beijing Medical University Third College; of Clinical Medicine, P.R. China.; Human cytomegalovirus (HCMV) is highly prevalent in the population, especially, the immunocompromised patients are at risk of severe and often fatal CMV diseases. In this regard, it is important to study reactivation of HCMV infection. Prior studies have shown that treatment of cel
Chickenpox in adults: clinical features and outcome.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 064). Unique Identifier : AIDSLINE AIDS/20710022; Wohlrab B; Reusser P; Department of Medicine, University of Hospital, Basel,; Switzerland.; Chickenpox is infrequent in adults, and its clinical features in this population have only been partially characterized. We reviewed retrospectively the medical charts of all patients (pts) >16 years old who presented at our hospital with chickenpox from 7/87 to 6/97. During this period, 25 pts with chickenpox were id
Absence of HHV8 in diseases unrelated to immunosuppression.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 068). Unique Identifier : AIDSLINE AIDS/20710023; Cathomas G; Regamey N; Stalder A; Kurrer M; Joller HI; Itin PH; Erb P; Tamm M; Department of Pathology and Clinical Immunology, University; Hospital, Zurich, Switzerland.; HHV8 can be detected in Kaposi s sarcoma, primary effusion lymphoma and multicentric Castleman disease, associated with AIDS or other forms of severe, prolonged immunosuppression. Recently, several reports suggest HHV8 as a cause of other diseases, usually not associated with AIDS or immunosuppression, including multi
Toxoplasmic uveitis in childhood.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 090). Unique Identifier : AIDSLINE AIDS/20710024; Velez A; Bontempi M; Lasarte P; Zampini L; Bogo R; Manolakis M; Unit of Infectology, Hospital S.M. Ludovica, La Plata, Argentina.; Ocular toxoplasmosis is an important cause of chorioretinitis. Persistent intraocular inflamation can result in sight-threatening complications. Objective: To analize symptoms, age, gender, clinical presentation and associated features in children with toxoplasmic uveitis. Method: From 102 patients with uveitis follow
A double-blind, randomized controlled trial of amphocil (ABCD) vs. Amphotericin B (AmB) for treatment of invasive aspergillosis in immunocompromised patients.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 091). Unique Identifier : AIDSLINE AIDS/20710025; Bowden R; Chandrasekar P; White M; van Burik JA; Wingard J; Fred Hutchinson Cancer Research Center, Seattle, WA.; Invasive aspergillosis is associated with a high mortality rate in immunocompromised patients. Lipid-based AmB products appear to have improved efficacy for treatment but have only been studied in historically controlled trials. We performed a large multicenter trial comparing ABCD (6/mg/kg/d) with AmB (1-1.5 mg/kg/d)
Candidemia due to multiple candidal species at a tertiary care institution.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 092). Unique Identifier : AIDSLINE AIDS/20710026; Pulimood S; Alangaden G; Chandrasekar PH; Division of Infectious Diseases, Department of Internal Medicine,; Wayne State University, Detroit, MI.; We examined the medical records of patients with candidemia due to multiple species that occurred during 1992-1995 at Harper Hospital. Eleven patients [3 men, 8 women; median age 67 years (range 21-85)] were identified with polyfungemia among 132 candidemic patients during 4-year study period. Median duration of hospi
Changing epidemiology of candidemia at a tertiary care institution.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 093). Unique Identifier : AIDSLINE AIDS/20710027; Pulimood S; Alangaden G; Chandrasekar PH; Division of Infectious Diseases, Department of Internal Medicine,; Wayne State University, Detroit, MI.; We retrospectively examined medical records of patients with candidemia at Harper Hospital during 1992-1995 and compared the findings with previous decade (Komshian et al. Rev Infect Dis 1989; 11:379) from the same institution. There were 132 candidemic episodes among 53 men and 79 women. Sixty-four (48%) patients had
Colonization and infection in neutropenic patients receiving either oral itraconazole (ITR) solution or amphotericin B (AmB) capsules for antifungal prophylaxis.: Unique Identifier : AIDSLINE AIDS/20710028; Dekker AW; vd Wal G; Rozenberg-Arska M; Department of Haematology, University Hospital Utrecht, the; Netherlands.; Forty patients from our department were included in a large multi centre, double-blind trial comparing ITR solution (2 bid 2.5 mg/kg) with AmB capsules (4 qid 500 mg) for fungal prophylaxis. Both groups were comparable regarding underlying disease and degree of neutropenia. The effect of the drugs on the colonization
Parasitic infections in the immunocompromised hosts (with case reports).: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 098). Unique Identifier : AIDSLINE AIDS/20710029; Hua J; Lian-Yin H; Department of Immunology and Parasitology, The Second Clinical; Medical School of Beijing Medical University, Beijing, P.R.; China.; There are 4 types of parasitic infections found in the immunocompromised hosts. 1. Pneumocystis carinii: It were very popular in the infants and children under 2 years old, it usualy expressed as interstitual pneumonia, a serial report 146 cases, 40% has been diagnosed as PCP, but due to difficult to collect sputum sp
Lipoproteins enhance the growth of candida albicans.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 099). Unique Identifier : AIDSLINE AIDS/20710030; Netea M; Curfs JH; Demacker PN; Meis JF; van der Meer JW; Kullberg BJ; University Hospital, Nijmegen, the Netherlands.; Objective: to determine the effects of lipoproteins on the growth of Candida albicans (CA) in vitro and in vivo after infusion of reconstituted high-density lipoproteins (rHDL) in human volunteers. rHDL infusion has been suggested as adjunctive therapy in Gram-negative sepsis. Methods: The various lipoprotein subfract
AmBisome compared with amphotericin B deoxycholate in the treatment of neutropenia-associated invasive fungal infections.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 100). Unique Identifier : AIDSLINE AIDS/20710031; Leenders AC; Daenen S; Jansen R; Hop WC; Lowenberg B; Wijermans PW; Cornelissen J; Herbrecht R; van der Lelie H; Hoogsteden HC; Verbrugh HA; de Marie S; University Hospital Dijkzigt, Rotterdam, The Netherlands.; Objective: To determine whether treatment with a high dose of AmBisome results in a better outcome of neutropenia-associated invasive fungal infections. Methods: In a randomized multicenter study, we compared AmBisome 5 mg/kg to amphotericin B (AmB) 1 mg/kg in the treatment of neutropenia associated invasive fungal in
Candida meningitis in children: two cases reports.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 103). Unique Identifier : AIDSLINE AIDS/20710032; Al Edress K; Al Shaalaan M; Memish Z; Alola S; King Fahad National Guard Hospital, Riyadh, Saudi Arabia.; Candida meningitis is rare in children, however reports are increasing recently. Here we report two cases of meningits caused by Candida species. The first case is a term boy who was admitted at 14 days of age with the diagnoses of possible sepsis. He received multiple courses of antibiotics without improvement. Later
Fungemia due to Exophiala janselmei. Report of 15 cases.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 106). Unique Identifier : AIDSLINE AIDS/20710033; Nucci M; Akiti T; Silveira F; Barreiros G; Rinaldi M; University Hospital, Universidade Federal do Rio de Janeiro,; Brazil.; Objective: To report cases of fungemia due to Exophiala janselmei occurring in an University Hospital in Rio de Janeiro, Brazil . Methods: Between December 1996 and September 1997 we identified an outbreak of fungemias due to black yeasts, further identified as Exophiala janselmei.
Epidemiological analysis of 22 cases of systemic hyphomycoses.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 107). Unique Identifier : AIDSLINE AIDS/20710034; Petrikkos G; Giamarellou H; Sabatakou H; Toskas A; Skiada A; Avlami A; Katsilambros N; 1st Department of Propedeutic Medicine, Laiko General Hospital,; Athens, Greece.; The aim of this study was to record and analyze the systemic hyphomycoses in adult patients that were hospitalized during a three-year period in an Internal Medicine Department of Laiko Hospital, in Athens. Twenty-two systemic mycoses were recorded (10 men and 12 women, mean ate 54 years). Aspergillus sp. was isolat
The macrophage migration inhibitory factor (MIF) arms human macrophages to restrict the growth of mycobacterium tuberculosis.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 124). Unique Identifier : AIDSLINE AIDS/20710035; Oddo M; Calandra T; Bucala R; Meylan PR; CHUV, Lausanne, Switzerland.; MIF is a cytokine with macrophage activating properties involved in the regulation of the inflammatory response. Objectives: to study (i) the production of MIF by human monocyte-derived macrophages (Mphi) infected with virulent (H37Rv) or attenuated (H37Ra) M. tuberculosis and with lipoarabinomannan derived from virul
Effects of interleukin (IL)-13 on antifungal activity of human monocytes against candida albicans.: Int Symp Infect Immunocompromised Host. 1998 Jun 21-24;10:(abstract no. 125). Unique Identifier : AIDSLINE AIDS/20710036; Katsifa H; Roilides E; Tsaparidou S; Diza E; Lehrnbecher T; Chanock S; Walsh T; Pediatric and Microbiology Depts, Aristotle U Thessaloniki,; Greece.; Objective: To investigate the effects of human IL-13, a cytokine with various immunoregulatory functions, on antifungal activities of human monocytes (MNC) against C. albicans. Method: Various concentrations of recombinant IL-13 (DNAX) were incubated with ficol/adherence isolated MNC from healthy adults for times rang
Human immunodeficiency virus type 1 envelope-specific cytotoxic T lymphocytes response dynamics after prime-boost vaccine regimens with human immunodeficiency virus type 1 canarypox and pseudovirions.: Viral Immunol. 1999;12(4):281-96. Unique Identifier : AIDSLINE MED/20094484; Arp J; Rovinski B; Sambhara S; Tartaglia J; Dekaban G; Robarts Research Institute, London, Ontario, Canada.; Virus-specific cytotoxic T lymphocytes (CTLs) may represent significant immune mechanisms in the control of human immunodeficiency virus (HIV) infection and, therefore, CTL induction may be a fundamental goal in the development of an efficacious acquired immunodeficiency syndrome (AIDS) vaccine. In the current study,
AIDS onset at high CD4+ cell levels is associated with high HIV load.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):103-7. Unique Identifier : AIDSLINE MED/20122175; Hennessey KA; Giorgi JV; Kaplan AH; Visscher BR; Gange S; Margolick JB; Riddler S; Phair J; Detels R; Los Angeles Center of the Multicenter AIDS Cohort Study,; Department of Epidemiology, UCLA School of Public Health,; California, USA.; To identify factors associated with development of AIDS at high CD4+ cell levels a nested case-control study using data from the Multicenter AIDS Cohort Study (MACS) was conducted. HIV-1-infected men who developed AIDS with > or =300/mm3 CD4+ cells (AIDS men) were compared to men who had > or =300/mm3 of CD4+ cells, b
Anti-cell antibodies in exposed seronegative individuals with HIV type 1-neutralizing activity.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):109-15. Unique Identifier : AIDSLINE MED/20122176; Lopalco L; Pastori C; Cosma A; Burastero SE; Capiluppi B; Boeri E; Beretta A; Lazzarin A; Siccardi AG; DIBIT and Infectious Diseases Clinic, San Raffaele Scientific; Institute, Milan, Italy. lopalco.lucia@hsr.it; Despite repeated exposures to HIV-1, some individuals remain seronegative. This study reports that sera from a fraction of exposed seronegative (ESN) subjects showed HIV-neutralizing activity; 5 of 17 ESN sera and none of 17 controls neutralized two different HIV-1 primary isolates (range of neutralizing titers: 1/20
Dependence of CD8+ T-cell-mediated suppression of HIV type 1 on viral phenotypes and mediation of phenotype-dependent suppression by viral envelope gene and not by beta-chemokines.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):117-24. Unique Identifier : AIDSLINE MED/20122177; Chen Y; Dampf D; Chen M; Kulka K; Volsky DJ; Saha K; Gupta P; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pennsylvania; 15261, USA.; CD8+ T-cell-mediated HIV-1 suppressive activity has been shown against a number of strains of HIV-1 and HIV-2. In this study using a semiquantitative assay, we showed that CD8+ T cells from seropositive subjects and herpes virus saimiri transformed CD8+ T-cell clones from HIV-1-infected subjects exhibited 5 to 100-fol
Attenuation of human immunodeficiency virus type 1 cytopathic effects by replacing a 424-bp region of envelope from a noncytopathic biological clone.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):125-37. Unique Identifier : AIDSLINE MED/20122178; Forte SE; Somasundaran M; Sullivan JL; Department of Pediatrics and Program in Molecular Medicine,; University of Massachusetts Medical School, Worcester 01605, USA.; We analyzed the env genes of cytopathic and noncytopathic biological clones derived from two HIV-1-infected children with discordant clinical courses. Chimeric viruses were constructed by switching env regions from V2 through V3 of the biological clones with the corresponding region from the molecular clone NL4-3. The
Near-full-length genome sequencing of divergent African HIV type 1 subtype F viruses leads to the identification of a new HIV type 1 subtype designated K.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):139-51. Unique Identifier : AIDSLINE GENBANK/AJ249239; Triques K; Bourgeois A; Vidal N; Mpoudi-Ngole E; Mulanga-Kabeya C; Nzilambi N; Torimiro N; Saman E; Delaporte E; Peeters M; Laboratoire Retrovirus, Institut de Recherche pour le; Developpement, Montpellier, France.; We recently reported a high divergence among African subtype F strains. Three well-separated groups (F1, F2, and F3) have been shown based on the phylogenetic analysis of the p24 gag and envelope sequences with genetic distances similar to those observed for known subtypes. In this study, we characterized the near-ful
Immunogenicity of a vaccine preparation representing the variable regions of the HIV type 1 envelope glycoprotein.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):153-61. Unique Identifier : AIDSLINE MED/20122180; Carlos MP; Anderson DE; Gardner MB; Torres JV; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis 95616, USA.; Variability of the major antigenic sites of the envelope glycoprotein of HIV-1 constitutes a major problem in the formulation of effective vaccines. We have prepared a synthetic peptide vaccine that represents the major hypervariable epitopes (V1 through V5) of the clade B HIV-1 envelope glycoprotein (gp120). We refer
Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):163-71. Unique Identifier : AIDSLINE MED/20122181; Habis A; Baskin G; Simpson L; Fortgang I; Murphey-Corb M; Levy LS; Department of Microbiology and Immunology, Tulane Cancer Center,; Tulane University School of Medicine, New Orleans, Louisiana; 70112, USA.; SAIDS-associated lymphoma (SAL) represents a monoclonal expansion of B-cell origin in which simian immunodeficiency virus (SIV) infection is not detected. However, tumor cells are frequently infected with rhesus lymphocryptovirus (RhLCV), a rhesus homologue of Epstein-Barr virus (EBV). In previous studies, the inciden
Differential gene expression in B-cell non-Hodgkin's lymphoma of SIV-infected monkey.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):173-9. Unique Identifier : AIDSLINE MED/20122182; Tarantul VZ; Nikolaev AI; Martynenko A; Hannig H; Hunsmann G; Bodemer W; Institute of Molecular Genetics, Department of Viral and Cellular; Molecular Genetics, Moscow, Russia. tarantul@img.ras.ru; Infection with SIVmac251 in some rhesus monkeys (Macaca mulatta) leads to B-cell non-Hodgkin s lymphomas (B-NHL) clinically similar to that of HIV-infected AIDS patients. To further characterize the SIV-associated B-NHL we have generated genetic profiles of malignant cells by subtractive hybridization and Northern blo
Distribution of the CCR5 delta32 allele in Italian HIV type 1-infected and normal individuals [letter]: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):181-2. Unique Identifier : AIDSLINE MED/20122183; Battiloro E; Andreoni M; Parisi SG; Mura MS; Sotgiu G; Aceti A; Cossu G; Concia E; Verna R; D'Ambrosio E
Recombinant bacillus Calmette-Guerin as a potential vector for preventive HIV type 1 vaccines.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):91-8. Unique Identifier : AIDSLINE MED/20122173; Falk LA; Goldenthal KL; Esparza J; Aguado MT; Osmanov S; Ballou WR; Beddows S; Bhamarapravati N; Biberfeld G; Ferrari G; Hoft D; Honda M; Jackson A; Lu Y; Marchal G; McKinney J; Yamazaki S; U.S. Food and Drug Administration, Center for Biologics; Evaluation and Research, Office of Vaccines Research and Review,; Rockville, Maryland 20852-1448, USA.; In August 1997, the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS ( UNAIDS ) convened an expert working group to discuss current strategies for the development of HIV type 1 vaccines. Based on the recent findings o
Allelic distribution of CCR5 and CCR2 genes in an Italian population sample.: AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):99-101. Unique Identifier : AIDSLINE MED/20122174; Romano-Spica V; Ianni A; Arzani D; Cattarini L; Majore S; Dean M; Institute of Hygiene and Public Health, Faculty of Medicine of; the Catholic University, Rome, Italy. romanospica@caspur.it; Genetic polymorphisms of CCR5 and CCR2 human chemokine receptors have been associated with resistance during HIV-1 infection and disease progression. The protective effect of mutant alleles at these loci has important implications in AIDS pathogenesis. Chemokine receptors have a role in viral entry into target cells a
IL-12 is produced by antigen-presenting cells stimulated with soluble alphabeta TCR and restores impaired T(h)1 responses.: Int Immunol. 2000 Jan;12(1):103-12. Unique Identifier : AIDSLINE MED/20076292; Kawamoto K; Paliwal V; Ramabhadran R; Szczepanik M; Tsuji RF; Matsuda H; Askenase PW; Department of Veterinary Surgery, College of Agriculture,; University of Osaka Prefecture, Sakai, Osaka 593, Japan.; Contact sensitivity (CS) is a cutaneous T(h)1 response that is induced by skin painting with reactive hapten. In prior in vivo studies of CS, we showed that recombinant soluble alphabetaTCR (sTCR) acted non-specifically to protect CS-effector T cells from suppression, but no molecular mechanism was determined. In the
Differential susceptibility of human T(h)1 versus T(h) 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells.: Int Immunol. 2000 Jan;12(1):57-66. Unique Identifier : AIDSLINE MED/20076287; Vandenbark AA; Barnes D; Finn T; Bourdette DN; Whitham R; Robey I; Kaleeba J; Bebo BF Jr; Miller SD; Offner H; Chou YK; Neuroimmunology Research R & D-31, Veterans Affairs Medical; Center, Portland, OR 97201, USA. Sc.; Antigen-coupled antigen-presenting cells (APC) serve as potent tolerogens for inhibiting immune responses in vivo and in vitro, apparently by providing an antigen-specific signal through the TCR in the absence of co-stimulation. Although this approach has been well studied in rodents, little is known about its effects
Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction.: Int Immunol. 2000 Jan;12(1):9-17. Unique Identifier : AIDSLINE MED/20076282; Allison J; Thomas H; Beck D; Brady JL; Lew AM; Elefanty A; Kosaka H; Kay TW; Huang DC; Strasser A; The Walter and Eliza Hall Institute for Medical Research, Post; Office, Royal Melbourne Hospital, Victoria 3050, Australia.; Insulin-dependent diabetes mellitus results when > 90% of the insulin-producing beta cells in the pancreatic islets are killed as a result of autoimmune attack by T cells. During the progression to diabetes, islet beta cells die as a result of different insults from the immune system. Agents such as perforin and granz
Vaccination with DNA encoding internal proteins of influenza virus does not require CD8(+) cytotoxic T lymphocytes: either CD4(+) or CD8(+) T cells can promote survival and recovery after challenge.: Unique Identifier : AIDSLINE MED/20076291; Epstein SL; Stack A; Misplon JA; Lo CY; Mostowski H; Bennink J; Subbarao K; Molecular Immunology Laboratory, Division of Cellular and Gene; Therapies, Center for Biologics Evaluation and Research, Food and; Drug Administration, HFM-521, Building 29B, Room 2G15, 29 Lincoln; DNA vaccination offers the advantages of viral gene expression within host cells without the risks of infectious virus. Like viral vaccines, DNA vaccines encoding internal influenza virus proteins can induce immunity to conserved epitopes and so may defend the host against a broad range of viral variants. CD8(+) cytot
Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables.: Br J Nutr. 1999 Nov;82(5):383-9. Unique Identifier : AIDSLINE MED/20138866; Watzl B; Bub A; Brandstetter BR; Rechkemmer G; Institute of Nutritional Physiology, Federal Research Centre for; Nutrition, Karlsruhe, Germany.; bernhard.watzl@bfe.uni-karlsruhe.de; A human intervention study was conducted to determine the effect of the consumption of carotenoid-rich vegetables on the immune system. Subjects, (twenty-three men), who were non-smokers, were not restricted in their daily diet, except that they had to abstain from fruit and vegetables high in carotenoids throughout t
Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.: Biochemistry. 2000 Jan 25;39(3):489-95. Unique Identifier : AIDSLINE MED/20108532; Briggs SD; Lerner EC; Smithgall TE; Eppley Institute for Research in Cancer and Department of; Pathology and Microbiology, University of Nebraska Medical; Center, Omaha, Nebraska 68198, USA.; Nef is an HIV accessory protein required for high-titer viral replication and AIDS progression. Previous studies have shown that the SH3 domains of Hck and Lyn bind to Nef via proline-rich sequences in vitro, identifying these Src-related kinases as potential targets for Nef in vivo. Association of Nef with Hck causes
Buried polar interactions and conformational stability in the simian immunodeficiency virus (SIV) gp41 core.: Biochemistry. 2000 Feb 1;39(4):676-85. Unique Identifier : AIDSLINE MED/20117371; Ji H; Bracken C; Lu M; Department of Biochemistry, Weill Medical College of Cornell; University, New York, New York 10021, USA.; For human (HIV) and simian (SIV) immunodeficiency viruses, the gp41 envelope protein undergoes a receptor-activated conformational change from a labile native structure to an energetically more stable fusogenic conformation, which then mediates viral-cell membrane fusion. The core structure of fusion-active gp41 is a
Genitourinary chlamydial infection: a reappraisal and hypothesis [editorial]: Int J STD AIDS. 1999 Dec;10(12):765-75. Unique Identifier : AIDSLINE MED/20102593; Morton RS; Kinghorn GR; Our understanding of genitourinary chlamydial infection and disease remains limited. That natural defences and/or apparently adequate treatments leave some patients with latent disease is suspected. There is, however, no consensus as to its nature. Furthermore, many patients, most obviously males, presenting with simi
Evaluation of self-taken samples for the presence of genital Chlamydia trachomatis infection in women using the ligase chain reaction assay.: Int J STD AIDS. 1999 Dec;10(12):776-9. Unique Identifier : AIDSLINE MED/20102594; Carder C; Robinson AJ; Broughton C; Stephenson JM; Ridgway GL; Department of Clinical Microbiology, University College London; Hospitals, UK.; The aim of this study was to evaluate the sensitivity and acceptability of self-taken vulval-introital (VI) samples, first-catch urine (FCU) samples and clinician-obtained cervical samples for the presence of genital Chlamydia trachomatis infections in women using the ligase chain reaction (LCR) assay. One hundred and
Intestinal protozoa in homosexual men in Edinburgh.: Int J STD AIDS. 1999 Dec;10(12):780-4. Unique Identifier : AIDSLINE MED/20102595; Pakianathan MR; McMillan A; Department of Medicine, Edinburgh Royal Infirmary, UK.; Our objective was to determine the prevalence of intestinal protozoa in homosexual men attending a sexually transmitted diseases (STD) clinic, to compare it with the prevalence in a previous study from the same clinic, and to examine the relationship, if any, between the presence of protozoa and sexual practices. Men
Condom shape: a neglected factor influencing use and acceptability? UK Family Planning Research Network.: Int J STD AIDS. 1999 Dec;10(12):785-90. Unique Identifier : AIDSLINE MED/20102596; Garside R; Institute of Population Studies, Postgraduate School of Medicine; and Health Sciences, University of Exeter, UK. r.garside@ex.ac.uk; Improving condom acceptability amongst users is one way to enhance efficacy. This study aimed to test whether or not the shape of a condom influenced users perceptions of condom acceptability as measured through their ratings of condom comfort, sensitivity and security. Four types of condoms were tested which had 3 d
A retrospective study of the addition of ciprofloxacin to clarithromycin and ethambutol in the treatment of disseminated Mycobacterium avium complex infection.: Int J STD AIDS. 1999 Dec;10(12):791-4. Unique Identifier : AIDSLINE MED/20102597; Keiser P; Nassar N; Skiest D; Rademacher S; Smith JW; University of Texas Southwestern Medical Center at Dallas,; 75235-9113, USA.; Disseminated Mycobacterium avium complex (DMAC) infection is associated with increased morbidity and mortality in HIV-infected individuals. The combination antibiotic regimens containing clarithromycin can decrease symptoms and improve survival in patients with DMAC, however, optimal therapy remains to be defined. Qui
HIV-related malignancies: community-based study using linkage of cancer registry and HIV registry data.: Int J STD AIDS. 1999 Dec;10(12):795-802. Unique Identifier : AIDSLINE MED/20102598; Cooksley CD; Hwang LY; Waller DK; Ford CE; Department of Medical Informatics, The University of Texas M. D.; Anderson Cancer Center, Houston 77030-4095, USA.; ccooksley@mdanderson.org; For people immunosuppressed by human immunodeficiency virus (HIV), we expect an increase in cancer incidence similar to that documented in transplant patients. We examined the cancer spectrum in an HIV-infected cohort, specifically malignancies not currently associated with acquired immunodeficiency syndrome (AIDS), i
Relationship between human papillomavirus (HPV) genotyping and genital neoplasia in HIV-positive patients of Santos City, Sao Paulo, Brazil.: Int J STD AIDS. 1999 Dec;10(12):803-7. Unique Identifier : AIDSLINE MED/20102599; Goncalves MA; Massad E; Burattini MN; Villa LL; School of Medicine, University of Sao Paulo, Brazil.; Among HIV-positive women, infection with multiple human papillomavirus (HPV) types is known to be more frequent and persistent, as well as a greater prevalence of high-grade genital lesions. This study aims to characterize, for the first time in Brazil , HPV presence and types among
Usefulness of information from the unlinked anonymous prevalence monitoring programme for HIV in England and Wales: survey of planners of HIV/AIDS services.: Int J STD AIDS. 1999 Dec;10(12):808-11. Unique Identifier : AIDSLINE MED/20102600; Kessel AS; Watts CJ; Epidemiology Unit, London School of Hygiene and Tropical; Medicine, UK. a.kessel@lshtm.ac.uk; The aim of this study was to evaluate whether information from the Unlinked Anonymous Prevalence Monitoring Programme for HIV in England and Wales is useful to planners of HIV/AIDS services. The study involved 2 stages: examination of 1997 AIDS Control Act Reports for England and Wales, and a telephone questionnaire s
HIV-infected workers deported from the Gulf States: impact on Southern Pakistan.: Int J STD AIDS. 1999 Dec;10(12):812-4. Unique Identifier : AIDSLINE MED/20102601; Shah SA; Khan OA; Kristensen S; Vermund SH; Sindh AIDS Control Programme, Karachi, Pakistan.; HIV prevalence is still very low in Pakistan , but its south Asian location and subgroups with recognized lifestyle risk factors suggest that Pakistan will experience expanded diffusion of HIV. We report the frequency of HIV infections identified by the AIDS Control Programme on t
The cellular immune system in female patients with or without genital warts: a study of peripheral white blood cell components.: Int J STD AIDS. 1999 Dec;10(12):815-6. Unique Identifier : AIDSLINE MED/20102602; Opaneye AA; Department of Genito-urinary Medicine, Middlesbrough General; Hospital, Cleveland, UK.; The immune system plays a vital role in the fight against infections. The commonest viral infections treated in the genitourinary medicine (GUM) departments are genital warts. Knowledge about the status of the immune system in these patients may help in their clinical management. This study compares the values of vari
Characteristics of HIV-infected men with low serum testosterone levels.: Int J STD AIDS. 1999 Dec;10(12):817-20. Unique Identifier : AIDSLINE MED/20102603; Kopicko JJ; Momodu I; Adedokun A; Hoffman M; Clark RA; Kissinger P; Department of Medicine, Louisiana State University Medical; Center, New Orleans 70112, USA.; Low levels of serum testosterone may have negative implications on morbidity in HIV-infected men. The purpose of this study was to determine demographic and clinical characteristics that predict low serum testosterone among men attending our HIV clinic. A cross-sectional study of 587 HIV-positive male patients who pre
Saccharomyces cerevisiae oesophagitis in an HIV-infected patient.: Int J STD AIDS. 1999 Dec;10(12):821-2. Unique Identifier : AIDSLINE MED/20102604; Konecny P; Drummond FM; Tish KN; Tapsall JW; Albion Street Centre, Surry Hills, Sydney, NSW, Australia.; jepkon@bigpond.com
Carcinoma of the penis preceded by Zoon's balanitis.: Int J STD AIDS. 1999 Dec;10(12):823-5. Unique Identifier : AIDSLINE MED/20102605; Joshi UY; Department of Genito-urinary Medicine and Sexual Health, Castle; Hill Hospital, Cottingham, East Yorkshire, UK.
Acceptability of the female condom amongst commercial sex workers in Thailand and Cote d'Ivoire [letter]: Int J STD AIDS. 1999 Dec;10(12):828-30. Unique Identifier : AIDSLINE MED/20102606; Deniaud F; Fampou-Toundji JC
Hypertrophic pulmonary osteoarthropathy in acquired immunodeficiency syndrome. Case report and review.: Invest Clin. 1999 Dec;40(4):267-76. Unique Identifier : AIDSLINE MED/20131605; Carreiro-Rodriguez M; Hernandez-Blanca D; Fernandez LM; Montes de Oca I; Castillo E; Sanchez JL; Department of Internal Medicine, Dr Domingo Luciani General; Hospital, Caracas, Venezuela.; We describe a case of hypertrophic pulmonary osteoarthropathy (HPOA) in an adult patient with acquired immunodeficiency syndrome (AIDS). This is the ninth case of HPOA associated with AIDS in adults, reported in the literature. The presence of pulmonary tuberculosis was also suspected, based on clinical grounds. Cases
Clinical and immunologic response without decrease in virus load in patients with AIDS after 24 months of highly active antiretroviral therapy [see comments]: Clin Infect Dis. 1999 Dec;29(6):1423-30. Unique Identifier : AIDSLINE MED/20053925; Mezzaroma I; Carlesimo M; Pinter E; Muratori DS; Di Sora F; Chiarotti F; Cunsolo MG; Sacco G; Aiuti F; Department of Allergy and Clinical Immunology, University of Rome; "La Sapienza," Viale dell'Universita, 00185 Rome, Italy.; This study reports an analysis of clinical, virological, and immunologic outcomes in a cohort of 77 multidrug-experienced AIDS patients during 24 months of highly active antiretroviral therapy (HAART). Our results have shown a reduced risk of AIDS complications, prolonged survival, and immunologic benefit even in the
Discordance between virological, immunologic, and clinical outcomes of therapy with protease inhibitors among human immunodeficiency virus-infected patients [editorial; comment]: Clin Infect Dis. 1999 Dec;29(6):1431-4. Unique Identifier : AIDSLINE MED/20053926; Goetz MB
Mycobacterium kansasii septic arthritis: French retrospective study of 5 years and review.: Clin Infect Dis. 1999 Dec;29(6):1455-60. Unique Identifier : AIDSLINE MED/20053930; Bernard L; Vincent V; Lortholary O; Raskine L; Vettier C; Colaitis D; Mechali D; Bricaire F; Bouvet E; Sadr FB; Lalande V; Perronne C; Service des Maladies Infectieuses et Tropicales, Hopital; Universitaire Raymond-Poincare, 92380 Garches Cedex, France.; l.bernard@rpc.ap-hop-paris.fr.; Septic arthritis due to Mycobacterium kansasii is rare; only 40 cases have been published. A French national inquiry revealed the occurrence of 10 new cases between 1992 and 1997 (8 men and 2 women: mean age, 37 years; range, 25-54 years). Seven had an underlying condition: AIDS (n=4), chronic skin psoriasis and AIDS
Comparison of high and low doses of trimethoprim-sulfamethoxazole for primary prevention of toxoplasmic encephalitis in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1999 Dec;29(6):1461-6. Unique Identifier : AIDSLINE MED/20053931; Ribera E; Fernandez-Sola A; Juste C; Rovira A; Romero FJ; Armadans-Gil L; Ruiz I; Ocana I; Pahissa A; Servicio de Enfermedades Infecciosas, Hospital General Vall; d'Hebron, 08035 Barcelona, Spain. eribera@hg.vhebron.es.; To evaluate the influence of the dose of co-trimoxazole prophylaxis on the risk of toxoplasmosis in human immunodeficiency virus (HIV)-infected patients, we performed a nested case-control study of 32 patients with toxoplasmosis (case patients) and 64 patients without toxoplasmosis (control patients) who were matched
Association of primary Pneumocystis carinii infection and sudden infant death syndrome.: Clin Infect Dis. 1999 Dec;29(6):1489-93. Unique Identifier : AIDSLINE MED/20053936; Vargas SL; Ponce CA; Hughes WT; Wakefield AE; Weitz JC; Donoso S; Ulloa AV; Madrid P; Gould S; Latorre JJ; Avila R; Benveniste S; Gallo M; Belletti J; Lopez R; Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago,; Chile. svargas@reuna.cl.; To delineate clinical and histological features of the first Pneumocystis carinii infection affecting the immunocompetent host, P. carinii-specific histological stains were performed on autopsy lung specimens from 534 consecutive pediatric patients (those with AIDS and malignancies were excluded) in Santiago,
Pneumocystis carinii pneumonia in human immunodeficiency virus (HIV)-positive and HIV-negative immunocompromised patients.: Clin Infect Dis. 1999 Dec;29(6):1519-23. Unique Identifier : AIDSLINE MED/20053941; Nuesch R; Bellini C; Zimmerli W; Division of Infectious Diseases, University Hospitals Basel,; CH-4031 Basel, Switzerland.; For 89 human immunodeficiency virus (HIV)-positive and 32 HIV-negative immunocompromised patients who had 121 episodes of Pneumocystis carinii pneumonia (PCP), clinical features and changes over time were compared. HIV-infected patients characteristically had a longer duration of symptoms (23 vs. 13 days; P
Spectrum of opportunistic infections and malignancies in patients with human immunodeficiency virus infection in South Korea.: Clin Infect Dis. 1999 Dec;29(6):1524-8. Unique Identifier : AIDSLINE MED/20053942; Oh MD; Park SW; Kim HB; Kim US; Kim NJ; Choi HJ; Shin DH; Lee JS; Choe K; Department of Internal Medicine, Seoul National University; College of Medicine, Seoul National University Hospital, Seoul,; 110-744, South Korea.; To determine the frequency and types of major opportunistic diseases in patients with HIV infection in South Korea , we reviewed the medical records of 173 HIV-infected patients. The patients were seen from 1985 to 1998 at a referral
Cell-mediated immune responses and loss of hepatitis B e-antigen (HBeAg) during successful lamivudine and famciclovir combination therapy for chronic replicating hepatitis B virus infection.: Clin Infect Dis. 1999 Dec;29(6):1575-7. Unique Identifier : AIDSLINE MED/20053955; Hultgren C; Weiland O; Milich DR; Sallberg M; Divisions of Clinical Virology, Basic Oral Sciences, Karolinska; Institutet at Huddinge University Hospital, Huddinge, Sweden.
Detection of human herpesvirus 8 in cervical cells of Chinese women with abnormal papanicolaou smears.: Clin Infect Dis. 1999 Dec;29(6):1584-5. Unique Identifier : AIDSLINE MED/20053961; Chan PK; Li WH; Chan MY; Cheng AF; Department of Microbiology, Chinese University of Hong Kong,; Prince of Wales Hospital, Shatin, Hong Kong SAR, China.; paulkschan@cuhk.edu. hk.
Ritonavir enables combined therapy with rifampin and saquinavir.: Clin Infect Dis. 1999 Dec;29(6):1586. Unique Identifier : AIDSLINE MED/20053962; Veldkamp AI; Hoetelmans RM; Beijnen JH; Mulder JW; Meenhorst PL; Slotervaart Hospital, Department of Pharmacy and Pharmacology,; 1066 EC Amsterdam, The Netherlands. APABG@SLZ.NL
Shigella boydii as cause of malacoplakia in a human immunodeficiency virus-infected patient [letter]: Clin Infect Dis. 1999 Dec;29(6):1602. Unique Identifier : AIDSLINE MED/20053975; Altwegg M; Hinrikson HP
AIDS care nursing: looking forward, thinking back [editorial]: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):22-3. Unique Identifier : AIDSLINE MED/20134899; Sowell RL
An investigation of the relationship between vitamin B12 deficiency and HIV infection.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):24-8, 31-5. Unique Identifier : AIDSLINE MED/20134900; Balt CA; Indiana University, Indianapolis Department of Medicine, USA.; The symptoms of vitamin B12 deficiency and several symptoms common to HIV infection overlap. Additionally, persons with HIV infection have frequently been found to have vitamin B12 deficiency. Therefore, the issue of concern is the prevalence of B12 deficiency in HIV-infected persons. A retrospective study of 63 medic
The Client Adherence Profiling-Intervention Tailoring (CAP-IT) intervention for enhancing adherence to HIV/AIDS medications: a pilot study.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):36-44. Unique Identifier : AIDSLINE MED/20134901; Holzemer WL; Henry SB; Portillo CJ; Miramontes H; Department of Community Health Systems, School of Nursing,; University of California, San Francisco, USA.; This article describes the Client Adherence Profiling-Intervention Tailoring (CAP-IT) intervention designed to enhance adherence to HIV/AIDS medications and reports the results of a pilot study aimed at assessing the feasibility of CAP-IT. Initially, CAP-IT was designed to be implemented by nurse case managers during
A team approach to the treatment of AIDS wasting.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):45-56. Unique Identifier : AIDSLINE MED/20134902; Abbaticola MM; Despite the aggressive use of antiretroviral agents, AIDS wasting (AW) affects many persons infected with HIV. AW is characterized by a disproportionate loss of metabolically active tissue, specifically body cell mass--tissue involved with glucose oxidation, protein synthesis, and immune system function. AW correlates
The utility of the Transtheoretical Model of behavior change for HIV risk reduction in injection drug users.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):57-66. Unique Identifier : AIDSLINE MED/20134903; Patten S; Vollman A; Thurston W; Department of Community Health Sciences, Faculty of Medicine,; University of Calgary.; The spread of HIV among injection drug users (IDUs) is the second most common mode of transmission next to sexual contact. Although HIV infections can be prevented by changing high-risk behaviors such as needle sharing, these high-risk behaviors are highly complex. Initially developed for smoking cessation, Prochaska
The Transtheoretical Model and stress management practices in women at risk for, or infected with, HIV.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):67-77. Unique Identifier : AIDSLINE MED/20134904; Riley TA; Toth JM; Fava JL; University of Akron College of Nursing, USA.; Although scientific inquiry using the Transtheoretical Model of Behavior (TTM) supports various behavior changes in multiple samples, no research was found that examined this model with women already infected with HIV. This article provides a brief overview of the related literature and describes a pilot study that ev
Immune reconstitution in the HAART era, Part 1: Immune abnormalities in HIV/AIDS.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):78-81. Unique Identifier : AIDSLINE MED/20134905; Agnoli MM; Rush-Presbyterian-St. Luke's Medical Center, USA.; Highly active antiretroviral therapy (HAART) has dramatically altered the course of HIV infection. HAART has been associated with a substantial decrease in HIV-related morbidity and mortality and an improved quality of life for many persons living with HIV/AIDS. This improvement is due to suppression of viral replicat
Nevirapine prevents vertical HIV-1 transmission.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):82-5. Unique Identifier : AIDSLINE MED/20134906; Porche DJ; Louisiana State University Health Sciences Center in New Orleans,; USA.
Developing your idea for a research project.: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):86-8. Unique Identifier : AIDSLINE MED/20134907; Sharts-Hopko NC; Villanova University College of Nursing, USA.
Program offers recognition of extraordinary partnerships in HIV care [news]: J Assoc Nurses AIDS Care. 2000 Jan-Feb;11(1):89-90. Unique Identifier : AIDSLINE MED/20134908
Child care workers and workplace hazards in the United States: overview of research and implications for occupational health professionals.: Occup Med (Lond). 1999 Sep;49(7):427-37. Unique Identifier : AIDSLINE MED/20128529; Bright KA; Calabro K; University of Texas-Houston Health Science Center, School of; Public Health, Southwest Center for Occupational and; Environmental Health, Houston 77225, USA.; In the past, the hazards facing child care workers have largely been ignored by health and safety professionals, due in part to a lack of awareness of hazards and inconsistencies in state health and safety requirements. The aim of this paper is to provide a summary and critique of the literature on the topic of occupa
Detection of vascular endothelial growth factor in AIDS-related primary effusion lymphomas [letter]: Blood. 2000 Feb 1;95(3):1109-10. Unique Identifier : AIDSLINE MED/20152443; Aoki Y; Tosato G; Nambu Y; Iwamoto A; Yarchoan R
Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells.: Blood. 2000 Feb 1;95(3):807-14. Unique Identifier : AIDSLINE MED/20115161; Gustafsson A; Levitsky V; Zou JZ; Frisan T; Dalianis T; Ljungman P; Ringden O; Winiarski J; Ernberg I; Masucci MG; Microbiology and Tumor Biology Center, Karolinska Institet,; Stockholm, Sweden.; A semiquantitative polymerase chain reaction assay was used to monitor the blood levels of Epstein-Barr virus (EBV)-DNA in 9 patients receiving allogeneic bone marrow transplants (BMT). Four of 5 recipients of HLA-mismatched T-cell-depleted grafts showed a 4- to 5-log increase of EBV-DNA within 1 to 3 months after BMT
Long-term multilineage expression in peripheral blood from a Moloney murine leukemia virus vector after serial transplantation of transduced bone marrow cells.: Blood. 2000 Feb 1;95(3):829-36. Unique Identifier : AIDSLINE MED/20115164; Austin TW; Salimi S; Veres G; Morel F; Ilves H; Scollay R; Plavec I; SyStemix Inc, Palo Alto, CA 94304, USA.; tim.austin@pharma.novartis.com; Using a mouse bone marrow transplantation model, the authors evaluated a Moloney murine leukemia virus (MMLV)-based vector encoding 2 anti-human immunodeficiency virus genes for long-term expression in blood cells. The vector also encoded the human nerve growth factor receptor (NGFR) to serve as a cell-surface marker
Atopic dermatitis and HTLV-1-associated myelopathy: associated or coincidental disorders?: Dermatology. 1999;199(4):356-60. Unique Identifier : AIDSLINE MED/20108646; Shohat M; Ben Amitai D; Shohat B; Mosberg R; Narinski R; Klein T; Okon E; Roizman P; Cowan EP; Alexander R; David M; Department of Dermatology, Rabin Medical Center, Beilinson; Campus, Petah Tikva, Israel.; Reports from Jamaica have indicated that some patients with infective dermatitis or atopic dermatitis (AD) are seropositive for antibodies to human T-lymphotropic virus type 1 (HTLV-1). We describe a 32-year-old Israeli woman with long-term AD and paresthesia in the distal parts o
Hydroxyurea in the treatment of HIV-1.: Ann Pharmacother. 2000 Jan;34(1):89-93. Unique Identifier : AIDSLINE MED/20132674; Gibbs MA; Sorensen SJ; College of Pharmacy and Health Sciences, Butler University,; Indianapolis, IN, USA.; OBJECTIVE: To describe the role of hydroxyurea in the treatment of HIV-1. DATA SOURCES: Published clinical studies using hydroxyurea in HIV treatment were accessed through MEDLINE (January 1994-March 1999) and conference abstracts. All relevant studies were evaluated. DATA SYNTHESIS: Adherence, expense, and resistance
Umbilical cord blood T lymphocytes are induced to apoptosis after being allo-primed in vitro.: Bone Marrow Transplant. 1999 Dec;24(11):1229-33. Unique Identifier : AIDSLINE MED/20107425; Hagihara M; Chargui J; Gansuvd B; Tsuchida F; Sato T; Hotta T; Kato S; Department of Hematology and Rheumatology, Tokai University; School of Medicine, Kanagawa, Japan.; In this study, the immunity of umbilical cord blood (UCB) T lymphocytes against allo-antigens was investigated by a standard MLC. No significant difference, between the UCB T cells or peripheral blood (PB) mature T cells, was observed in the primary responses (stimulation index (SI), 51.8 +/- 14.8 and 46.5 +/- 15.0, r
Serum neopterin concentrations during treatment of leishmaniasis: useful as test of cure?: FEMS Immunol Med Microbiol. 2000 Jan;27(1):31-4. Unique Identifier : AIDSLINE MED/20084949; Hamerlinck FF; van Gool T; Faber WR; Kager PA; Department of Dermatology, University of Amsterdam, Academic; Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The; Netherlands. angelcos@euronet.nl; Neopterin, a product of gamma-interferon-activated macrophages, was measured in sera from 28 patients (12 patients with cutaneous leishmaniasis and 16 patients with visceral leishmaniasis) to determine the utility as a marker of disease activity and therapeutic efficacy. Patients originated from
Current laboratory assays and in vitro intracellular Th1 and Th2 cytokine synthesis in monitoring antiretroviral therapy of pediatric HIV infection.: FEMS Immunol Med Microbiol. 2000 Jan;27(1):67-71. Unique Identifier : AIDSLINE MED/20084954; Voiculescu C; Avramescu C; Radu E; Balasoiu M; Turculeanu A; University of Medicine and Pharmacy, Department of Microbiology; and Immunology, Petru Rares Street 4, 1100, Craiova, Romania.; voicul@medinf.comp-craiova.ro; In 42 HIV-infected children, 8-10 years old, belonging to the category A state of infection, combined antiretroviral therapy (cART) was applied, consisting of AZT , ddC and Saquinavir.
Practice behaviors of RNs related to hazardous risks within the clinical setting.: Medsurg Nurs. 1999 Jun;8(3):174-7. Unique Identifier : AIDSLINE MED/20127006; Gordon GP; Masters in Nursing Program, University of Phoenix, USA.; A practice behavior survey was distributed to 250 RNs in the Metropolitan Detroit area. Seventy percent of the RNs responded to questions focused on needle-stick and splash injuries, handwashing, gloving, and other available measures that prevent injuries and infection. Respondents reported a larger than expected numb
Current management of AIDS and related opportunistic infections.: Medsurg Nurs. 1999 Aug;8(4):257-64. Unique Identifier : AIDSLINE MED/20127016; Cochran A; Wilson BA; Loyola University, New Orleans, LA, USA.; Significant changes in acquired immunodeficiency syndrome (AIDS) epidemiology and AIDS treatment strategies have emerged in the 17 years since the first case of this disease was reported. In the United States , the human immunodeficiency virus (HIV) is now primarily acquired through het
Images for surgeons. Fatal opportunistic necrotizing colitis.: J Am Coll Surg. 2000 Feb;190(2):264. Unique Identifier : AIDSLINE MED/20120357; Witte CL; Byers JM 3rd; University of Arizona Health Sciences Center, Tucson, USA.
Stable gene transfer to the nervous system using a non-primate lentiviral vector.: Gene Ther. 1999 Nov;6(11):1808-18. Unique Identifier : AIDSLINE MED/20070359; Mitrophanous K; Yoon S; Rohll J; Patil D; Wilkes F; Kim V; Kingsman S; Kingsman A; Mazarakis N; Oxford BioMedica (UK) Ltd, Oxford, UK.; We have constructed a non-primate lentiviral vector system based on the equine infectious anaemia virus (EIAV). This system is able to transduce both dividing and non-dividing cells, including primary cultured hippocampal neurons and neurons and glia in the adult rat central nervous system (CNS), at efficiencies compa
Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activity.: Gene Ther. 1999 Dec;6(12):1911-8. Unique Identifier : AIDSLINE MED/20105615; Boyle DL; Nguyen KH; Zhuang S; Shi Y; McCormack JE; Chada S; Firestein GS; Division of Rheumatology, Allergy and Immunology, UCSD School of; Medicine, La Jolla, CA 92093-0656, USA.; Gene therapy has been explored as a potential method for treating chronic inflammatory diseases such as rheumatoid arthritis. To determine the efficacy of intra-articular IL-4 gene therapy in an animal model of arthritis using a retroviral vector, a retrovirus encoding rat IL-4 (DA-IL-4) was engineered, purified and c
Interferon-alpha gene therapy in combination with CD80 transduction reduces tumorigenicity and growth of established tumor in poorly immunogenic tumor models.: Gene Ther. 1999 Dec;6(12):1988-94. Unique Identifier : AIDSLINE MED/20105623; Hiroishi K; Tuting T; Tahara H; Lotze MT; Department of Surgery, University of Pittsburgh School of; Medicine, PA 15261, USA.; Interferon-alpha (IFN-alpha) or CD80 transduction of tumor cells individually reduces tumorigenicity and enhances antitumor responses. Here, we report that the combination of IFN-alpha and CD80 cancer gene therapy in poorly immunogenic murine tumor models, the colorectal adenocarcinoma cell line MC38, and the methylch
The sCYMV1 hairpin ribozyme: targeting rules and cleavage of heterologous RNA.: Gene Ther. 1999 Jun;6(6):1114-9. Unique Identifier : AIDSLINE MED/99387172; Lian Y; De Young MB; Siwkowski A; Hampel A; Rappaport J; Department of Biological Sciences, Northern Illinois University,; DeKalb, IL 60115, USA.; The catalytic center of the RNA from the negative strand of the satellite RNA of chicory yellow mottle virus type 1 (sCYMV1) is in the hairpin ribozyme family, has catalytic activity, and cleaves substrates before a preferred GUA sequence. This is different from that of the satellite RNA from the negative strand of to
Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus-pseudotype retroviral vector.: Gene Ther. 1999 Jun;6(6):966-72. Unique Identifier : AIDSLINE MED/99387156; Kiem HP; McSweeney PA; Bruno B; Goerner M; Buron G; Morris J; Storb R; Miller AD; Clinical Research, Fred Hutchinson Cancer Research Center,; Seattle, WA 98109-1024, USA.; We have used dogs to study gene transfer into hematopoietic stem cells, because of the applicability of results in dogs to human transplantation and the availability of canine disease models that mimic human diseases. Previously we reported successful gene transfer into canine marrow repopulating cells, however, gene
Recombinant AAV-2 harboring gfp-antisense/ribozyme fusion sequences monitor transduction, gene expression, and show anti-HIV-1 efficacy.: Unique Identifier : AIDSLINE MED/99387189; Horster A; Teichmann B; Hormes R; Grimm D; Kleinschmidt J; Sczakiel G; Deutsches Krebsforschungszentrum, Forschungsschwerpunkt; Vector-mediated delivery of potentially antivirally active genes is a key step in somatic gene therapy including therapeutic approaches against AIDS. A crucial technical prerequisite is to monitor DNA transfer into target cells. Here, we describe recombinant infectious particles derived from the adeno-associated virus
NF-kappaB activation and HIV-1 induced apoptosis.: Cytokine Growth Factor Rev. 1999 Sep-Dec;10(3-4):235-53. Unique Identifier : AIDSLINE MED/20112305; DeLuca C; Kwon H; Lin R; Wainberg M; Hiscott J; Lady Davis Institute for Medical Research, Department of; Microbiology, McGill AIDS Center, McGill University, Montreal,; Canada.; HIV infection leads to the progressive loss of CD4+ T cells and the near complete destruction of the immune system in the majority of infected individuals. High levels of viral gene expression and replication result in part from the activation of NF-kappaB transcription factors, which in addition to orchestrating the
[Cerebellar syndrome and peripheral neuropathy as manifestations of infection by HTLV-1 human T-cell lymphotropic virus]: Rev Neurol. 1999 Nov 16-30;29(10):932-5. Unique Identifier : AIDSLINE MED/20103198; Carod-Artal FJ; del Negro MC; Vargas AP; Rizzo I; Servicio de Neurologia, Red Sarah de Hospitales del Aparato; Locomotor, Brasilia DF, Brasil. javier@bsb.sarah.br; INTRODUCTION: Type I human T-cell lymphotropic virus (HTLV-I) is a retrovirus with affinity for CD4 cells. This infection may give rise to a broad spectrum of disorders including T-cell leucemia/lymphoma, the myelopathy/tropical spastic paraparesis complex (M/TSP), and to a lesser extent, uveitis, arthritis, polymyosi
Descriptive epidemiology of non-Hodgkin lymphomas in a southwestern French hematology center: absence of significant relationship with hepatitis C virus infection.: Hematol Cell Ther. 1999 Nov;41(5):191-3. Unique Identifier : AIDSLINE MED/20114539; Bauduer F; Katsahian S; Blanchard Y; Oui B; Capdupuy C; Renoux M; Service d'Hematologie, Centre Hospitalier de la Cote Basque,; Bayonne, France.; From January 1995 to June 1998, 136 new cases of non-Hodgkin lymphomas (NHLs) were seen in our center which serves all the French Basque Country (300000 inhabitants). The crude and standardized incidence rates were respectively 13.2 and 7.6 cases/100000/year. The distribution of histologic subtypes according to the RE
Neurocysticercosis and acquired cerebral toxoplasmosis in children.: Semin Pediatr Neurol. 1999 Dec;6(4):267-77. Unique Identifier : AIDSLINE MED/20114095; Mitchell WG; Department of Neurology, Children's Hospital Los Angeles, CA; 90027, USA.; Neurocysticercosis, prevalent wherever pigs are raised in the presence of poor sanitation, is the most common identifiable cause of new-onset epilepsy throughout the developing world. As immigration patterns have changed, children with neurocysticercosis are seen throughout the United Stat
Neuroimaging of postnatal pediatric central nervous system infections.: Unique Identifier : AIDSLINE MED/20114098; Hedlund GL; Boyer RS; Pediatric neuroimaging plays an important role in the timely diagnosis of postnatal central nervous system (CNS) infections, and in some patients the imaging findings are sufficiently specific to suggest a cause. The sequela of CNS infection, including hydrocephalus, subdural collections, ischemia/infarction, cerebral
Classic kaposi sarcoma: epidemiology and risk factors.: Cancer. 2000 Feb 1;88(3):500-17. Unique Identifier : AIDSLINE MED/20115351; Iscovich J; Boffetta P; Franceschi S; Azizi E; Sarid R; The International Fertility Institute and Department of; Epidemiology, Selikoff Center of Environmental Health and Human; Development, Ra'anana, Israel.; BACKGROUND: Although Kaposi sarcoma (KS) initially was described over a century ago, its biology remains enigmatic and conflicting. Whereas the classic type occurs mainly in older men of Mediterranean or Eastern European backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immu
Lung carcinoma in 36 patients with human immunodeficiency virus infection. The Italian Cooperative Group on AIDS and Tumors.: Cancer. 2000 Feb 1;88(3):563-9. Unique Identifier : AIDSLINE MED/20115359; Tirelli U; Spina M; Sandri S; Serraino D; Gobitti C; Fasan M; Sinicco A; Garavelli P; Ridolfo AL; Vaccher E; Division of Medical Oncology A, Aviano Cancer Center, Aviano,; Italy.; BACKGROUND: The current study describes the clinicopathologic characteristics of 36 patients with lung carcinoma and human immunodeficiency virus (HIV) infection observed within the Italian Cooperative Group on AIDS and Tumors (GICAT). METHODS: Patients with lung carcinoma and HIV infection collected by the GICAT betw
Evaluating the quality of cancer care: development of cancer quality indicators for a global quality assessment tool.: Cancer. 2000 Feb 1;88(3):701-7. Unique Identifier : AIDSLINE MED/20115377; Malin JL; Asch SM; Kerr EA; McGlynn EA; Department of Medicine, University of California, Los Angeles, CA; 90095-6900, USA.; BACKGROUND: The rise of managed care has increased interest in measuring, reporting, and improving quality of care. To date, quality assessment has relied on a leading indicator approach, which may miss important variations in care. The authors developed cancer specific indicators using a novel case-based approach for
Human immunodeficiency virus negative Kaposi sarcoma and lymphoproliferative disorders [letter]: Cancer. 2000 Feb 1;88(3):708-9. Unique Identifier : AIDSLINE MED/20115378; Kadri Altundag M; Celik I
The impact of HIV-related neuropsychological dysfunction on driving behavior. The HNRC Group.: J Int Neuropsychol Soc. 1999 Nov;5(7):579-92. Unique Identifier : AIDSLINE MED/20110296; Marcotte TD; Heaton RK; Wolfson T; Taylor MJ; Alhassoon O; Arfaa K; Grant I; University of California at San Diego, Department of Psychiatry,; USA. tmarcotte@ucsd.edu; HIV infection often results in neuropsychological (NP) impairment. In order to assess the impact that HIV-related NP deficits may have on automobile driving, we evaluated 68 HIV-seropositive drivers using an NP battery and two PC-based driving simulations. Thirty-two participants were classified as NP impaired; most (
Temperature inducible beta-sheet structure in the transactivation domains of retroviral regulatory proteins of the Rev family.: Unique Identifier : AIDSLINE MED/20095446; Thumb W; Graf C; Parslow T; Schneider R; Auer M; The interaction of the human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev with cellular cofactors is crucial for the viral life cycle. The HIV-1 Rev transactivation domain is functionally interchangeable with analog regions of Rev proteins of other retroviruses suggesting common folding patterns. In or
Predictors for extraintestinal infection of non-typhoidal Salmonella in patients without AIDS.: Int J Clin Pract. 1999 Apr-May;53(3):161-4. Unique Identifier : AIDSLINE MED/20128510; Chiu CH; Lin TY; Ou JT; Department of Medicine, Chang Gung Children's Hospital, Taoyuan,; Taiwan.; To identify the risks and predictors for extraintestinal infection (EII) in patients with non-typhoidal salmonellosis, we undertook a study of 398 patients with cultures positive for non-typhoidal Salmonella seen at Chang Gung Memorial Hospital and Chang Gung Children s Hospital between November 1993 and October 1994.
Hypercalcaemia: a clue to Mycobacterium avium intracellulare infection in a patient with AIDS.: Int J Clin Pract. 1999 Apr-May;53(3):227-8. Unique Identifier : AIDSLINE MED/20128524; Aly ES; Baig M; Khanna D; Baumann MA; Department of Medicine, Wright State University School of; Medicine, Dayton, Ohio, USA.; Hypercalcaemia is uncommon in HIV-infected patients and should suggest a different priority for differential diagnosis than would be considered in other settings. Although hypercalcaemia has long been associated with granulomatous diseases including tuberculosis, it has only recently been recognised that patients with
Transmission of tuberculosis in an endemic urban setting in Brazil.: Int J Tuberc Lung Dis. 2000 Jan;4(1):18-25. Unique Identifier : AIDSLINE MED/20118800; Ferrazoli L; Palaci M; Marques LR; Jamal LF; Afiune JB; Chimara E; Martins MC; Silva Telles MA; Oliveira CA; Palhares MC; Spada DT; Riley LW; Instituto Adolfo Lutz, Divisao de Biologia Medica, Sao Paulo,; Brazil. lucilafe@usp.br; SETTING: Two out-patient facilities in Sao Paulo, Brazil . OBJECTIVE: To study the transmission pattern of tuberculosis (TB) among human immunodeficiency virus (HIV) infected and uninfected persons in a setting endemic for TB. DESIGN: A prospective study comparing HIV-seropositive a
Sex differences in the epidemiology of tuberculosis in San Francisco.: Int J Tuberc Lung Dis. 2000 Jan;4(1):26-31. Unique Identifier : AIDSLINE MED/20118801; Martinez AN; Rhee JT; Small PM; Behr MA; Division of Pulmonary and Critical Care Medicine, University of; California, San Francisco, USA.; SETTING: Worldwide differences in sex-specific tuberculosis case rates remain fundamentally unexplained. OBJECTIVE: To explore various factors that may explain sex differences in tuberculosis incidence rates for San Francisco from 1991-1996. DESIGN: A retrospective epidemiologic analysis of sex-specific tuberculosis i
Mycobacterium tuberculosis and human immunodeficiency virus co-infection in intravenous drug users on admission to prison.: Int J Tuberc Lung Dis. 2000 Jan;4(1):41-6. Unique Identifier : AIDSLINE MED/20118804; Martin V; Cayla JA; Bolea A; Castilla J; Medical Service, Penitentiary Centre, Leon, Spain.; med007784@nacom.es; BACKGROUND: Intravenous drug users (IDUs) and prisoners are groups of great interest in human immunodeficiency virus (HIV) infection and tuberculosis (TB) epidemiology. AIM: To determine predictors and temporal trends of the co-infection of Mycobacterium tuberculosis and HIV in IDUs on admission to prison. PATIENTS AN
Prevalence and risk factors for positive tuberculin skin tests among active drug users at a syringe exchange program.: Int J Tuberc Lung Dis. 2000 Jan;4(1):47-54. Unique Identifier : AIDSLINE MED/20118805; Salomon N; Perlman DC; Friedmann P; Ziluck V; Des Jarlais DC; Department of Medicine, Beth Israel Medical Center, New York, New; York 10003, USA. nsalomon@bethisraelny.org; OBJECTIVES: To evaluate the prevalence and predictors of tuberculin skin test (TST) reactions > or =10 mm among active injection drug users (IDUs) at a syringe exchange program in New York City. METHODS: From August 1995 to January 1996, participants were offered TB screening, an interview, and received $15.00 upon re
Factors predicting non-completion of tuberculosis treatment among HIV-infected patients in Barcelona (1987-1996).: Int J Tuberc Lung Dis. 2000 Jan;4(1):55-60. Unique Identifier : AIDSLINE MED/20118806; Tanguis HG; Cayla JA; Garcia de Olalla PG; Jansa JM; Brugal MT; Epidemiology Service, Municipal Institute of Public Health of; Barcelona, Spain. hgaldos@imsb.bcn.es; OBJECTIVE: To determine the predictive factors of non-completion of tuberculosis (TB) treatment among patients infected with the human immunodeficiency virus (HIV). DESIGN: Between 1987 and 1996, 2201 HIV-infected TB patients were detected by the Barcelona Tuberculosis Prevention and Control Programme. Patients who co
Effectiveness of infection control measures in controlling a nosocomial outbreak of multidrug-resistant tuberculosis among HIV patients in Italy.: Int J Tuberc Lung Dis. 2000 Jan;4(1):61-8. Unique Identifier : AIDSLINE MED/20118807; Moro ML; Errante I; Infuso A; Sodano L; Gori A; Orcese CA; Salamina G; D'Amico C; Besozzi G; Caggese L; Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Rome, Italy.; SETTING: Between October 1992 and February 1994, 33 cases of multidrug-resistant tuberculosis (MDR-TB) were diagnosed among patients infected by the human immunodeficiency virus (HIV) and hospitalised in an HIV ward in Milan, Italy . This outbreak was part of a much larger outbreak,
Further consequences of thioacetazone-induced cutaneous reactions [letter]: Int J Tuberc Lung Dis. 2000 Jan;4(1):92-3. Unique Identifier : AIDSLINE MED/20118813; Lawn SD; Griffin GE
Synthesis and antiviral studies of unsaturated analogues of isomeric dideoxynucleosides.: Nucleosides Nucleotides. 1999 Nov-Dec;18(11-12):2379-95. Unique Identifier : AIDSLINE MED/20103928; Bera S; Mickle T; Nair V; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.; Novel isomeric dideoxynucleosides with unsaturation in the carbohydrate moiety have been synthesized. For example, isod4A was synthesized through a rearrangement reaction involving a cyclonucleoside. Support for the structures of both purine and pyrimidine d4 compounds came from UV, NMR, HRMS and single crystal X-ray
Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.: Nucleosides Nucleotides. 1999 Nov-Dec;18(11-12):2463-73. Unique Identifier : AIDSLINE MED/20103930; Boudou V; Imbach JL; Gosselin G; Laboratoire de Chimie