2000

Falls prevention over 2 years: a randomized controlled trial in women 80 years and older [see comments]: Age Ageing. 1999 Oct;28(6):513-8. Unique Identifier : AIDSLINE MED/20067990; Campbell AJ; Robertson MC; Gardner MM; Norton RN; Buchner DM; Department of Medicine, Dunedin School of Medicine, Otago Medical; School, New Zealand. john.campbell@stonebow.otago.ac.nz; BACKGROUND: after 1 year, a home-based programme of strength and balance retraining exercises was effective in reducing falls and injuries in women aged 80 years and older. The exercise programme had been individually prescribed by a physiotherapist during the first 2 months of a randomized controlled trial. OBJECTIVE
Is pathogenic humoral autoimmunity a Th1 response? Lessons from (for) myasthenia gravis.: Immunol Today. 2000 Jan;21(1):19-23. Unique Identifier : AIDSLINE MED/20107317; Balasa B; Sarvetnick N; Dept of Immunology, The Scripps Research Institute, La Jolla, CA; 92037, USA. bbalasa@scripps.edu
Immunopathology of schistosomiasis: a cautionary tale of mice and men.: Immunol Today. 2000 Jan;21(1):29-35. Unique Identifier : AIDSLINE MED/20107319; Fallon PG; Dept of Pathology, University of Cambridge, Tennis Court Road,; Cambridge, UK CB2 1QP. pgf20@cam.ac.uk
FTC warns against home-use tests for HIV [news]: Oncology (Huntingt). 1999 Dec;13(12):1706. Unique Identifier : AIDSLINE MED/20097277
Increased bleeding associated with protease inhibitor therapy in HIV-positive patients with bleeding disorders.: Br J Haematol. 1999 Dec;107(3):556-9. Unique Identifier : AIDSLINE MED/20050306; Wilde JT; Lee CA; Collins P; Giangrande PL; Winter M; Shiach CR; West Midlands Adult Comprehensive Care Haemophilia Unit, Queen; Elizabeth Hospital, Edgbaston, Birmingham.; april.greenway@university-b.smids.nhs.uk; The use of protease inhibitor (PI) drugs in treatment regimens for HIV-infected patients with hereditary bleeding disorders has been associated with an increased bleeding tendency. To characterize the nature of this bleeding tendency, a retrospective case record analysis was performed on 67 HIV-positive patients with
[Becoming partners: the meaning of caring for patients with HIV and AIDS]: Pflege. 1999 Aug;12(4):230-7. Unique Identifier : AIDSLINE MED/20045872; Spirig R; Fachhochschule Aargau Gesundheit und Soziale Arbeit, Aarau.; The purpose of this study was to understand and describe what constitutes caring as experienced by persons living with HIV and AIDS (PLWAs) along their illness trajectory. Interpretative phenomenology was employed. Six men and one woman living with HIV or AIDS participated in open-ended interviews. Interviews were ana
Role of glycosphingolipids in HIV-1 entry: requirement of globotriosylceramide (Gb3) in CD4/CXCR4-dependent fusion.: Biosci Rep. 1999 Aug;19(4):317-25. Unique Identifier : AIDSLINE MED/20055942; Puri A; Hug P; Jernigan K; Rose P; Blumenthal R; Section of Membrane Structure and Function, LECB, Division of; Basic Sciences, National Cancer Institute, National Institutes of; Health, Frederick, MD 21702-1201, USA. apuri@helix.nih.gov; We have recently shown that addition of human erythrocyte glycosphingolipids (GSL) to non-human CD4+ or GSL-depleted human CD4+ cells rendered those cells susceptible to gp120-gp41-mediated cell fusion (Puri et al., BBRC, 1998). One GSL fraction (Fraction 3) isolated from human erythrocyte GSL mixture exhibited the hi
Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes.: Blood. 2000 Jan 1;95(1):231-40. Unique Identifier : AIDSLINE MED/20076262; Vukmanovic-Stejic M; Vyas B; Gorak-Stolinska P; Noble A; Kemeny DM; Department of Immunology, Guy's, King's, and St. Thomas' School; of Medicine, Rayne Institute, London, United Kingdom.; It has recently become clear that distinct subsets of CD8 T cells, analogous to their CD4 counterparts, exist in rodents and humans. To examine functional differences between human CD8 T-cell subsets, we generated Tc1, Tc2, and Tc0 T-cell clones from the peripheral blood of healthy individuals. The majority of CD8 T-c
Application of the ELISPOT assay to the characterization of CD8(+) responses to Epstein-Barr virus antigens.: Blood. 2000 Jan 1;95(1):241-8. Unique Identifier : AIDSLINE MED/20076263; Yang J; Lemas VM; Flinn IW; Krone C; Ambinder RF; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, MD 21231, USA.; CD8(+) cells have an important role in controlling Epstein-Barr virus (EBV) infection. We adapted the interferon-gamma ELISPOT assay to the quantitative analysis of EBV-specific CD8(+) cells. Using peripheral blood mononuclear cells (PBMCs) from healthy donors, we measured both the aggregate response to the virus, usi
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).: Blood. 2000 Jan 1;95(1):249-55. Unique Identifier : AIDSLINE MED/20076264; Hazenberg MD; Stuart JW; Otto SA; Borleffs JC; Boucher CA; de Boer RJ; Miedema F; Hamann D; Department of Clinical Viro-Immunology, CLB, Academic Medical; Center, University of Amsterdam, Amsterdam, The Netherlands.; In human immunodeficiency virus (HIV)-1 infection, highly increased T-cell turnover was proposed to cause exhaustion of lymphocyte production and consequently development of AIDS. Here, we investigated cell proliferation, as measured by expression of the Ki-67 nuclear antigen, in peripheral blood CD4(+) and CD8(+) lym
Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells.: Blood. 2000 Jan 1;95(1):30-8. Unique Identifier : AIDSLINE MED/20076236; Hasegawa H; Nomura T; Kohno M; Tateishi N; Suzuki Y; Maeda N; Fujisawa R; Yoshie O; Fujita S; First Department of Internal Medicine, Ehime University School of; Medicine, Shigenobu, Ehime 791-0295, Japan.; hitoshih@m.ehime-u.ac.jp; Adult T-cell leukemia (ATL) is characterized by infiltration of various tissues by circulating ATL cells, a finding often associated with a poor prognosis. Leukocyte migration from the circulation into tissues depends on integrin-mediated adhesion to the endothelium, and integrins are tightly regulated by several fact
Changes in human immunodeficiency virus type 1 virus load during mobilization and harvesting of hemopoietic progenitor cells. Adult AIDS Clinical Trials Group 285 Study Team.: Blood. 2000 Jan 1;95(1):48-55. Unique Identifier : AIDSLINE MED/20076238; Campbell TB; Sevin A; Coombs RW; Peterson GC; Rosandich M; Kuritzkes DR; Mladenovic J; Landay A; Wong R; Ambruso D; Miles S; Pomerantz RJ; Schooley RT; University of Colorado Health Sciences Center and Bonfils Blood; Center, Denver, CO 80262, USA. thomas.campbell@uchsc.edu; Genetic modification of hemopoietic progenitor cells ex vivo, followed by the infusion of the genetically modified cells into the human immunodeficiency virus-1 (HIV-1) infected donor, has been proposed as a treatment for HIV-1 infection. The current study was undertaken to evaluate the effect of hemopoietic stem cell
C-C chemokine profile of cord blood mononuclear cells: selective defect in RANTES production.: Blood. 2000 Jan 15;95(2):715-8. Unique Identifier : AIDSLINE MED/20094702; Hariharan D; Ho W; Cutilli J; Campbell DE; Douglas SD; Divisions of Neonatology and Immunologic and Infectious Diseases; and the Clinical Immunology Laboratories, The Children's Hospital; of Philadelphia, University of Pennsylvania School of Medicine,; Philadelphia, PA 19104, USA.; Three C-C chemokines inhibit human immunodeficiency virus (HIV) entry into macrophages: macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and regulated-upon activation, normal T-cell expressed and secreted (RANTES). We studied the ability of placental cord blood mononuclear cells (CBMC) to secrete these
Legal trends in bioethics.: J Clin Ethics. 1999 Summer;10(2):156-65. Unique Identifier : AIDSLINE MED/20099087; Forster HP; Case Western Reserve University School of Medicine, Cleveland,; Ohio, USA.
AZT in Africa [letter]: J Clin Ethics. 1999 Summer;10(2):166-7. Unique Identifier : AIDSLINE MED/20099089; Kottow MH
Comment: significant interactions with new antiretrovirals and psychotropic drugs [letter]: Ann Pharmacother. 1999 Dec;33(12):1372-3. Unique Identifier : AIDSLINE MED/20094539; Penzak SR; Grimsley SR; Jann MW
Comment: risk of drug-disease and disease-drug interactions with anticonvulsants in HIV-positive patients [letter]: Ann Pharmacother. 1999 Dec;33(12):1373-4. Unique Identifier : AIDSLINE MED/20094540; Jennings HR; Romanelli F
Effects of zidovudine (AZT) and dideoxyinosine (ddI) on human trophoblast cells.: Reprod Toxicol. 1999 Nov-Dec;13(6):537-46. Unique Identifier : AIDSLINE MED/20078563; Plessinger MA; Miller RK; University of Rochester School of Medicine and Dentistry,; Department of Obstetrics and Gynecology, New York 14642-8668,; USA. mark_plessinger@urmc.rochester.edu; The anti-HIV agents AZT (zidovudine) and ddl (dideoxyinosine) are being used clinically during pregnancy. The toxicity of these agents to the fetus and placenta remains a concern because few human pregnancy exposure data are available, and pregnant ro
Differential alteration by thalidomide of the glutathione content of rat vs. rabbit conceptuses in vitro.: Reprod Toxicol. 1999 Nov-Dec;13(6):547-54. Unique Identifier : AIDSLINE MED/20078564; Hansen JM; Carney EW; Harris C; University of Michigan, Department of Environmental and; Industrial Health Toxicology Program, Ann Arbor 48109-2029, USA.; Thalidomide has been shown to cause limb reduction defects in rabbits with much greater potency than in rats, possibly due to inherent biochemical differences between the two species. Whole embryo culture was used to make direct comparisons between thalidomide-sensitive New Zealand
Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization.: Cereb Cortex. 1999 Dec;9(8):824-32. Unique Identifier : AIDSLINE MED/20074214; Delalle I; Takahashi T; Nowakowski RS; Tsai LH; Caviness VS Jr; Department of Neurology, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA. idellale@partners.org; We have analyzed the expression patterns of mRNAs of five cell cycle related proteins in the ventricular zone of the neocortical cerebral wall over the course of the neuronogenetic interval in the mouse. One set of mRNAs (cyclin E and p21) are initially expressed at high levels but expression then falls to a low asymp
Gene therapy: lessons learnt from the past decade [interview by Clare Thompson]: BMJ. 1999 Nov 13;319(7220):1310. Unique Identifier : AIDSLINE MED/20025707; Morgan RA; Blaese RM
Supplementation with Lactobacillus reuteri or L. acidophilus reduced intestinal shedding of cryptosporidium parvum oocysts in immunodeficient C57BL/6 mice.: Cell Mol Biol (Noisy-le-grand). 1999 Sep;45(6):855-63. Unique Identifier : AIDSLINE MED/20007494; Alak JI; Wolf BW; Mdurvwa EG; Pimentel-Smith GE; Kolavala S; Abdelrahman H; Suppiramaniam V; Department of Biology, Tuskegee University, Alabama 36088, USA.; Jalak@acd.tusk.edu; The effect of L. acidophilus supplementation to reduce fecal shedding of Cryptosporidium parvum oocysts was compared to L. reuteri using C57BL/6 female mice immunosuppressed by murine leukemia virus (strain LP-BM5) inoculation. After 12 weeks post LP-BM5 inoculation, 15 immunosuppressed mice each were randomly assinge
[Vimentin intermediate filaments are involved in replication of human immunodeficiency virus type I]: Dokl Akad Nauk. 1999 Oct;368(5):706-8. Unique Identifier : AIDSLINE MED/20080094; Khakhulina TV; Vorkunova GK; Manukhina EE; Bukrinskaia AG
Survey of diagnosed HIV infections shows prevalence is rising.: Commun Dis Rep CDR Wkly. 1999 Nov 19;9(47):1. Unique Identifier : AIDSLINE MED/20099826
Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1).: Cell Adhes Commun. 1999;7(3):183-93. Unique Identifier : AIDSLINE MED/20090329; Schenkel AR; Pauza CD; Department of Pathology and Laboratory Medicine and Wisconsin; Regional Primate Research Center, University of; Wisconsin-Madison, 53706, USA.; Pertussis toxin treatment in macaques inhibits lymphocyte extravasation from the blood and leads to transient lymphocytosis and leukocytosis. We examined lymphocyte adhesion molecules known to be involved in the extravasation process to find possible mechanisms for the effects of pertussis toxin treatment. The two sub
Study requirements for investigating HLA-associated progression of HIV disease, and review.: QJM. 1999 Oct;92(10):609-17. Unique Identifier : AIDSLINE MED/20093353; Gore SM; Hutchinson SJ; Brettle RP; MRC Biostatistics Unit, Cambridge, UK.
Long-term outcome of chronic hepatitis C virus infection in primary hypogammaglobulinaemia.: QJM. 1999 Aug;92(8):433-41. Unique Identifier : AIDSLINE MED/20093329; Bjoro K; Skaug K; Haaland T; Froland SS; Department of Medicine, National Hospital, Oslo, Norway.; The clinical course of HCV infection in patients with primary hypogammaglobulinaemia appears to be more severe than in immunocompetent patients. We studied the long-term course of chronic HCV infection in 20 Norwegian hypogammaglobulinaemia patients with a 13-15 year known history of HCV infection. Twelve of 20 patien
Multinucleated giant cell formation by microglia: induction by interleukin (IL)-4 and IL-13.: Brain Res. 1999 Dec 4;849(1-2):239-43. Unique Identifier : AIDSLINE MED/20074719; Suzumura A; Tamaru T; Yoshikawa M; Takayanagi T; Department of Neurology, Nara Medical University, 840 Shijo-cho,; Kashihara, Nara, Japan. asuzumur@naramed-u.ac.jp; To investigate the cellular origin and the mechanisms of multinucleated giant cell (MGC) formation in the CNS, various cytokines were applied to isolated murine microglia. All the single cytokines failed to induce MGC. However, interleukin (IL)-13 and IL-4 induced microglial MGC formation in the presence of colony sti
Stopping anti-CMV therapy may be safe option for some HIV patients [news]: Am J Health Syst Pharm. 2000 Jan 1;57(1):21. Unique Identifier : AIDSLINE MED/20094248
Costs and savings of investigational drug services.: Am J Health Syst Pharm. 2000 Jan 1;57(1):40-3. Unique Identifier : AIDSLINE MED/20094251; McDonagh MS; Miller SA; Naden E; School of Pharmacy, University of Washington, Seattle 98195, USA.; The costs and savings resulting from two pharmacy-based investigational drug services (IDSs) for fiscal year 1996-97 were studied. The costs and savings associated with IDSs at two joint institutions were calculated by adding the cost-avoidance figures (money that would most likely have been spent, but was not because
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells.: Immunity. 1999 Dec;11(6):677-88. Unique Identifier : AIDSLINE MED/20090316; Kurata H; Lee HJ; O'Garra A; Arai N; Department of Immunobiology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, California 94304, USA.; Stat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein that can be activated by 4-hydroxy-tamoxifen, independently of IL-4 and endogenous Stat6. Retrovirus-mediated introduction of Stat6:ER into devel
Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses.: Immunity. 1999 Dec;11(6):733-42. Unique Identifier : AIDSLINE MED/20090321; Selin LK; Lin MY; Kraemer KA; Pardoll DM; Schneck JP; Varga SM; Santolucito PA; Pinto AK; Welsh RM; Department of Pathology, University of Massachusetts Medical; School, Worcester 01655, USA.; Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells s
The role of advanced practice in today's infectious diseases.: Crit Care Nurs Q. 1999 Feb;21(4):22-30. Unique Identifier : AIDSLINE MED/20111907; Davis S; Massachusetts General Hospital, Boston, USA.; The importance of the role of an advanced practice nurse in infectious diseases has been heightened by the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic. The unique abilities that are part of the expanded role enable the advanced practice nurse to utilize tools learned as a nurse
HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system.: Int J Biochem Cell Biol. 1999 Dec;31(12):1443-52. Unique Identifier : AIDSLINE MED/20104764; Idriss H; Kawa S; Damuni Z; Thompson EB; Wilson SH; Sealy Center for Molecular Science, The University of Texas; Medical Branch Galveston, TX 77555-0851, USA. hi@st-and.ac.uk; Phosphorylation modulates the activity of many proteins that interact with nucleic acids including DNA and RNA polymerases. The HIV-1 reverse transcriptase (RT) is essential during the replicative cycle of the HIV-1 virus. HIV-1 RT has several potential sites for phosphorylation that could regulate its activities. In
Treatment of two patients with diffuse cutaneous leishmaniasis caused by Leishmania mexicana modifies the immunohistological profile but not the disease outcome.: Trop Med Int Health. 1999 Dec;4(12):801-11. Unique Identifier : AIDSLINE MED/20098847; Salaiza-Suazo N; Volkow P; Tamayo R; Moll H; Gillitzer R; Perez-Torres A; Perez-Montfort R; Dominguez JD; Velasco-Castrejon O; Crippa M; Becker I; Departamento de Medicina Experimental, Faculdad de Medicina,; UNAM, Mexico.; Two patients with diffuse cutaneous leishmaniasis caused by Leishmania mexicana were treated with two leishmanicidal drugs (pentamidine and allopurinol) combined with recombinant interferon-gamma restoring Th-1 favouring conditions in the patients. Parasites decreased dramatically in the lesions and macrophages dimini
Spontaneous gingival bleeding in an otherwise asymptomatic patient.: Compend Contin Educ Dent. 1999 Oct;20(10):936-40. Unique Identifier : AIDSLINE MED/20116154; Tyler MT; Hutchison JL; Rybka WB; Division of Oral Medicine and Radiology, Faculty of Dentistry,; McGill University, Montreal, Quebec, Canada.; This case is presented to challenge the reader to formulate a differential diagnosis for a patient who visits the dentist with spontaneous, continuous gingival bleeding. When this situation occurs, it is serious and requires immediate attention and a specific treatment plan to arrive at the underlying diagnosis and co
Occupational HIV infections in health care workers.: Compend Contin Educ Dent. 1999 Sep;20(9):882-4, 886. Unique Identifier : AIDSLINE MED/20114217; Molinari JA; Department of Biomedical Sciences, University of Detroit Mercy; School of Dentistry, USA.
Porcine endogenous retroviral mRNAs in pancreas and a panel of tissues from specific pathogen-free pigs.: Diabetes Metab. 1999 Dec;25(6):518-25. Unique Identifier : AIDSLINE MED/20099696; Clemenceau B; Lalain S; Martignat L; Sai P; ENVN, Nantes, France.; Pigs are potential providers of donor tissues for xenotransplantation (e.g. of pancreatic islets) in Type 1 diabetes. In this context, our group has studied the use of islets from specific pathogen-free (SPF) pigs as a means of reducing the risks of conventional zoonosis . Although this approach does not prevent the
Kaposi sarcoma of major salivary gland origin: A clinicopathologic series of six cases.: Cancer. 2000 Jan 1;88(1):15-23. Unique Identifier : AIDSLINE MED/20086736; Castle JT; Thompson LD; Department of Oral and Maxillofacial Pathology, Armed Forces; Institute of Pathology, Washington, DC 20306-6000, USA.; BACKGROUND: Kaposi sarcoma (KS), one of the defining tumors of acquired immune deficiency syndrome (AIDS), is rarely identified in the major salivary glands. To the authors knowledge, no previous published series has evaluated the clinicopathologic aspects of this tumor in major salivary glands. METHODS: Six cases of
HIV infection as a risk factor for shigellosis.: Emerg Infect Dis. 1999 Nov-Dec;5(6):820-3. Unique Identifier : AIDSLINE MED/20070440; Baer JT; Vugia DJ; Reingold AL; Aragon T; Angulo FJ; Bradford WZ; California Emerging Infections Program, San Francisco,; California, USA; We investigated cases of shigellosis in San Francisco and Alameda Counties identified during 1996 by active laboratory surveillance to assess the role of HIV infection as a risk factor for shigellosis. Dramatically elevated rates of shigellosis in HIV-infected persons implicate HIV infection as an important risk facto
The first reported case of Aerococcus bacteremia in a patient with HIV infection [letter]: Emerg Infect Dis. 1999 Nov-Dec;5(6):838-9. Unique Identifier : AIDSLINE MED/20070448; Razeq JH; Thomas GM; Alexander D
CD46 is a cellular receptor for human herpesvirus 6.: Unique Identifier : AIDSLINE MED/20084452; Santoro F; Kennedy PE; Locatelli G; Malnati MS; Berger EA; Lusso P; Unit of Human Virology, DIBIT, San Raffaele Scientific Institute,; Milano, Italy.; Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, causes opportunistic infections in immunocompromised patients, and has been implicated in multiple sclerosis and in the progression of AIDS. Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downreg
Blood mononuclear cells in patients with HTLV-I-associated myelopathy: lymphocytes are highly activated and adhesion to endothelial cells is increased.: Cell Immunol. 1999 Nov 25;198(1):1-10. Unique Identifier : AIDSLINE MED/20080777; Al-Fahim A; Cabre P; Kastrukoff L; Dorovini-Zis K; Oger J; Department of Medicine, University of British Columbia,; Vancouver, British Columbia, V6T 1W5, Canada.; We have investigated lymphocyte subpopulations and blood mononuclear cell (MNC) adhesion to activated endothelial monolayers in patients with human T lymphotropic virus type I (HTLV-I) associated myelopathy (HAM), in HTLV-I asymptomatic carriers (carriers), and in seronegative controls. HAM patients and carriers had h
MHC-restricted protection of cats against FIV infection by adoptive transfer of immune cells from FIV-vaccinated donors.: Cell Immunol. 1999 Nov 25;198(1):30-43. Unique Identifier : AIDSLINE MED/20080780; Pu R; Omori M; Okada S; Rine SL; Lewis BA; Lipton E; Yamamoto JK; Department of Pathobiology, College of Veterinary Medicine,; University of Florida, Gainesville, Florida 32611, USA.; The role of cellular immunity in vaccine protection against FIV infection was evaluated using adoptive cell transfer studies. Specific-pathogen-free cats received two adoptive transfers of washed blood cells from either vaccinated or unvaccinated donors with varying MHC compatibility at 1-week intervals, and a homolog
Microglia exhibit clonal variability in eliciting cytotoxic T lymphocyte responses independent of class I expression.: Cell Immunol. 1999 Nov 25;198(1):44-53. Unique Identifier : AIDSLINE MED/20080781; Bergmann CC; Yao Q; Stohlman SA; Department of Neurology, University of Southern California Keck; School of Medicine, Los Angeles 90033, USA.; Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones
Replication timing of CD4 and CD8 in single-positive peripheral blood lymphocytes.: Cell Immunol. 1999 Nov 25;198(1):61-8. Unique Identifier : AIDSLINE MED/20080783; Hibbard MK; Strehl S; Lalande M; Genetics Division, Children's Hospital and Harvard Medical; School, Boston, Massachusetts 02115, USA.; The regulatory events leading to the mutually exclusive expression of CD4 and CD8 on peripheral lymphocytes are not fully understood. In particular, the association between DNA replication timing and transcriptional activity of these genes has not been previously investigated. Here, the replication kinetics of the CD4
Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity.: Cell Immunol. 1999 Nov 25;198(1):69-75. Unique Identifier : AIDSLINE MED/20080784; Kobayashi H; Horner AA; Takabayashi K; Nguyen MD; Huang E; Cinman N; Raz E; Department of Medicine, University of California at San Diego,; 9500 Gilman Drive, La Jolla, California 92093-0663, USA.; Immunostimulatory DNA sequences (ISS) have been shown to promote CTL and Th1 immune responses to coinjected antigens. This phenomenon can be attributed to the capacity of ISS to induce the secretion of type-1 cytokines and to up regulate costimulatory ligands on antigen-presenting cells. We hypothesized that ISS admin
Conformational studies of irreversible HIV-1 protease inhibitors containing cis-epoxide as an amide isostere.: J Pept Res. 1999 Sep;54(3):242-8. Unique Identifier : AIDSLINE MED/99444750; Ro S; Baek SG; Lee B; Ok JH; Biotech Research Institute, LG Chemical Ltd, Research Park,; Taejon, Korea.; We have carried out NMR and molecular modeling studies of peptidomimetic HIV-1 protease inhibitors , LB71116: Qc-Asn-Phepsi[(1R,2S)-cis-epoxide]Gly-NH-CH(isopropyl)2 where Qc stands for quinaldic acid and LB71148: Qc-(SMe)Pen(O)2-Phepsi[(1R,2S)-cis-epoxide]Gly-NH-CH(
AIDS-related Kaposi's sarcoma: principal pathogenic mechanisms.: J Exp Clin Cancer Res. 1999 Sep;18(3):311-5. Unique Identifier : AIDSLINE MED/20072191; Silvestris N; Divisione di Chirurgia Oncologica, Ospedale Vittorio Emanuele II,; Bisceglie, Italy.; Kaposi s sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppre
Update on study 006--EFV + AZT + 3TC versus the current 'standard of care' IDV + AZT + 3TC.: Int J Clin Pract Suppl. 1999 Jun;103:10-5. Unique Identifier : AIDSLINE MED/20087917; Staszewski S; Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.; Study 006 is a pivotal Phase III, multicentre, randomized, open-label study designed to compare the antiretroviral activity and tolerability of efavirenz (EFV) + zidovudine ( AZT ) + la
Review of NNRTIs: 'today and tomorrow'.: Int J Clin Pract Suppl. 1999 Jun;103:16-20. Unique Identifier : AIDSLINE MED/20087918; Katlama C; Service des Maladies Infectieuses Parasitaires et Tropicales,; Groupe Hospitalier Pitie-Salpetriere, Paris, France.; Since 1996 indinavir in combination with zidovudine + lamivudine has been the standard regimen in the treatment of HIV infection. Although protease inhibitor (PI) containing therapies are very potent, many problems have now been identified that reduce
Efavirenz: resistance and cross-resistance.: Int J Clin Pract Suppl. 1999 Jun;103:21-5. Unique Identifier : AIDSLINE MED/20087919; Clotet B; Hospital Universitari Germans Trias I Pujol, Badalona, Spain.; Resistant strains, the major cause of treatment failure in the management of HIV infection, evolve whenever virus replication is incompletely suppressed by drug therapy. In such cases, genotypic analysis of proviral DNA or phenotypic analysis of viral isolates or recombinant molecular clones can provide useful informa
Paediatric treatment issues.: Int J Clin Pract Suppl. 1999 Jun;103:26-9. Unique Identifier : AIDSLINE MED/20087920; Walters S; St Mary's Hospital Medical School, Imperial College, London, UK.; Compared with the therapeutic options available for the treatment of HIV infection in adults, the therapeutic options available for the treatment of paediatric patients is limited. New anti-HIV agents are needed to broaden the range of effective therapeutic options. However, several factors need to be considered when
Clinical history of efavirenz.: Int J Clin Pract Suppl. 1999 Jun;103:3-7. Unique Identifier : AIDSLINE MED/20087915; Ruiz N; DuPont Pharmaceuticals Company, Wilmington, USA.; Efavirenz (SUSTIVA, DMP 266, EFV) is a novel non-nucleoside reverse transcriptase inhibitor, which shows good inhibitory activity against HIV-1. The pharmacokinetics of efavirenz allow for once daily dosing without regard to meals of normal compositio
Efavirenz: practicalities, considerations and new issues.: Int J Clin Pract Suppl. 1999 Jun;103:30-4. Unique Identifier : AIDSLINE MED/20087921; Moyle G; Chelsea and Westminster Hospital, London, UK.; Concerns about the long-term safety issues with protease inhibitors (PIs) and recent reports of non-PI-containing regimens demonstrating potent and durable suppression of viral replication have brought into question the role of PI therapy. However, a number of issue
Coming therapies: abacavir.: Int J Clin Pract Suppl. 1999 Jun;103:35-8. Unique Identifier : AIDSLINE MED/20087922; Staszewski S; Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.; Abacavir is a nucleoside analogue reverse transcriptase inhibitor (NRTI). It has a good oral availability and penetrates the CNS. The metabolism of abacavir is not dependent on cytochrome P450 thus avoiding significant drug-drug interactions. It has a
Coming therapies: adefovir.: Unique Identifier : AIDSLINE MED/20087923; Angarano G; Adefovir dipivoxil, an acyclic nucleotide phosphonate analogue, demonstrates a potent and sustained antiviral activity. Its long half-life allows once daily administration and due to the observed reduction in L-carnitine plasma levels, supplementation
Coming therapies: amprenavir.: Int J Clin Pract Suppl. 1999 Jun;103:42-4. Unique Identifier : AIDSLINE MED/20087924; Gatell J; Hospital Clinic, Barcelona, Spain.; Amprenavir is a new peptidomimetic inhibitor of the HIV protease enzyme. Amprenavir has a twice daily dosing schedule and can be administered with or without food making it a convenient dosing regimen among the
The picture of future therapy.: Int J Clin Pract Suppl. 1999 Jun;103:45-8. Unique Identifier : AIDSLINE MED/20087925; Gazzard B; Chelsea and Westminster Hospital, London, UK.; Highly active antiretroviral therapy (HAART) consisting of 2 nucleoside reverse transcriptase inhibitors (NRTIs) in combination with a protease inhibitor (PI) or a non nucleoside reverse transcriptase inhibitor (NNRTI) is now regarded as the standard of care in the treatment of HIV infection. However, over the next fe
Interactive debate.: Int J Clin Pract Suppl. 1999 Jun;103:49-52. Unique Identifier : AIDSLINE MED/20087926; Gazzard B; An interactive voting session at the end of the European symposium on evolving therapies provided an opportunity for panel discussion on various therapeutic options based on a series of case studies. The interactive voting and subsequent discussion focused on the preferred options for first-line, second-line and salva
Dose-ranging studies.: Int J Clin Pract Suppl. 1999 Jun;103:8-9. Unique Identifier : AIDSLINE MED/20087916; Manion D; Worldwide Medical Affairs, DuPont Pharmaceuticals Company,; Wilmington, USA.; Several studies have been performed to investigate the appropriate dose of efavirenz (SUSTIVA, DMP 266, EFV) for the treatment of HIV infection. When considering the most appropriate dose, virological, pharmacological, clinical and safety data from these studies were examined.
High-performance liquid chromatographic method for the simultaneous determination of HIV-1 protease inhibitors indinavir, saquinavir and ritonavir in plasma of patients during highly active antiretroviral therapy.: J Chromatogr B Biomed Sci Appl. 1999 Nov 26;735(1):41-50. Unique Identifier : AIDSLINE MED/20094585; Langmann P; Klinker H; Schirmer D; Zilly M; Bienert A; Richter E; Department of Internal Medicine, University of Wurzburg,; Germany.; A new high-performance liquid chromatographic method for the simultaneous determination of indinavir , saquinavir and ritonavir in human plasma is described. Quantitative recovery foll
[Infections of the oral mucosa II. Bacterial, mycotic and viral infections]: Mund Kiefer Gesichtschir. 1999 Nov;3(6):298-308. Unique Identifier : AIDSLINE MED/20107893; Reichart PA; Zentrum fur Zahnmedizin, Universitatsklinikum Charite, Berlin.; petera.reichart@charite.de; Non-specific infections of the oral mucosa are rare; however, they may present during HIV infection in the form of gingivo-periodontal lesions. In some of these Candida albicans may play a role in the pathogenesis. Sexually transmitted bacterial infections such as gonorrhoea and syphilis are frequently associated with
Cure for cancer? AIDS vaccine? Not just yet....: Adv Nurse Pract. 1998 Dec;6(12):29-30, 32, 34. Unique Identifier : AIDSLINE MED/99132772; Leccese C
Candidiasis in children with HIV. A protocol for diagnosis and treatment.: Adv Nurse Pract. 1999 Jul;7(7):61-4. Unique Identifier : AIDSLINE MED/99404989; Schweisguth B; Valley Hospital, Ridgewood, N.J., USA.
Reducing AIDS risk among inner-city women: a review of the Collectivist Empowerment AIDS Prevention (CE-AP) Program.: J Eur Acad Dermatol Venereol. 1999 Nov;13(3):166-74. Unique Identifier : AIDSLINE MED/20105038; MacKenzie JE; Hobfoll SE; Ennis N; Kay J; Jackson A; Lavin J; Department of Psychology, Kent State University, Kent, OH 44242,; USA. jeanmack@aol.com; We discuss the process underlying our HIV-prevention project for young inner-city women. Health interventions are almost uniformly based on individualistic models of health and behavior. In contrast, AIDS and AIDS prevention, by their very social nature, may require more collectivist principles of disease, health, and
EMS provider reluctance to perform mouth-to-mouth resuscitation.: Prehosp Emerg Care. 2000 Jan-Mar;4(1):48-52. Unique Identifier : AIDSLINE MED/20097749; Melanson SW; O'Gara K; Emergency Medicine Residency, St. Luke's Hospital, Bethlehem,; Pennsylvania 18015, USA.; OBJECTIVES: To assess the willingness of EMS providers to perform mouth-to-mouth resuscitation (MMR) both with and without a barrier device (e.g., face shield), while not on duty; and to determine the providers perceived risk from performing MMR and the frequency with which they carry a barrier device. METHODS: A sur
EMTs' knowledge regarding transmission of infectious disease.: Prehosp Emerg Care. 2000 Jan-Mar;4(1):57-61. Unique Identifier : AIDSLINE MED/20097751; Mencl F; Birkle M; Blanda M; Gerson LW; Department of Emergency Medicine, Summa Health, Akron, Ohio; 44304, USA. menclf@summa-health.org; OBJECTIVE: To describe EMTs knowledge of CDC universal precaution guidelines and transmission routes for human immunodeficiency virus (HIV), hepatitis, meningitis, and tuberculosis (TB) and their perceived exposures to and concerns about these diseases. METHODS: A convenience sample of EMTs were surveyed at mandatory
Births and deaths: preliminary data for 1998.: Natl Vital Stat Rep. 1999 Oct 5;47(25):1-45. Unique Identifier : AIDSLINE MED/20106275; Martin JA; Smith BL; Mathews TJ; Ventura SJ; OBJECTIVES: This report presents preliminary data for 1998 on births and deaths in the United States . U.S. data on births are shown by age, race, and Hispanic origin of mother. Natality data on marital status, prenatal care, cesarean delivery, and low birthweight are also presented. Mo
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.: Bioorg Med Chem Lett. 1999 Dec 20;9(24):3411-6. Unique Identifier : AIDSLINE MED/20083372; Uckun FM; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Mao C; Venkatachalam TK; Drug Discovery Program, and Department of Virology, Hughes; Institute, St. Paul, MN 55113, USA.; The thiophene-ethyl thiourea (TET) compound N -[2-(2-thiophene)ethyl]-N -[2-(5-bromopyridyl)]-thiourea (compound HI-443) was five times more potent than trovirdine, 1250 times more potent than nevirapine , 100 times more potent than
Dilated cardiomyopathy associated with simian AIDS in nonhuman primates.: Circulation. 2000 Jan 18;101(2):185-93. Unique Identifier : AIDSLINE MED/20105251; Shannon RP; Simon MA; Mathier MA; Geng YJ; Mankad S; Lackner AA; Department of Medicine, Allegheny General Hospital, Pittsburgh,; PA 15212, USA. rshannon@pgh.auhs.edu; BACKGROUND: Cardiomyopathy is being recognized with increasing frequency in patients with AIDS, yet the relationship between HIV infection and cardiac contractile dysfunction remains obscure. The purpose of the present study was to determine if infection with simian immunodeficiency virus (SIV) in nonhuman primates is
Transbuccal permeation of a nucleoside analog, dideoxycytidine: effects of menthol as a permeation enhancer.: Int J Pharm. 1999 Dec 10;192(2):139-46. Unique Identifier : AIDSLINE MED/20037003; Shojaei AH; Khan M; Lim G; Khosravan R; Department of Pharmaceutical Sciences, School of Pharmacy, Texas; Tech University Health Sciences Center, Amarillo, TX 79106, USA.; The use of a safe and effective permeation enhancer is paramount to the success of a buccal drug delivery system intended for systemic drug absorption. The enhancing effects of menthol (dissolved in an aqueous buffer in the absence of co-enhancers) on buccal permeation of a model hydrophilic nucleoside analog, dideoxy
Management of opportunistic infections in acquired immunodeficiency syndrome. I. Treatment.: Am J Ther. 1998 Jan;5(1):45-9. Unique Identifier : AIDSLINE MED/20091246; Schlager SI; Department of Medicine, Finch University of Health Sciences/The; Chicago Medical School, North Chicago, IL, USA.; A case report of a patient infected with human immunodeficiency virus (HIV) is described. The patient presents with a multitude of medical complaints that are of acute or subacute onset. The medical examination of these complaints is described and includes algorithms for the diagnosis and treatment of the most common
University of Miami Division of Clinical Pharmacology therapeutic rounds: drug-induced hyperkalemia.: Am J Ther. 1998 Mar;5(2):125-32. Unique Identifier : AIDSLINE MED/20091259; Preston RA; Hirsh MJ MD; Oster JR MD; Oster HR MD; Department of Medicine, University of Miami School, 1500 NW 12th; Ave, 15th Floor West, Miami, Florida 33136, USA.; Drug-induced hyperkalemia is an important but often overlooked problem encountered commonly in clinical practice. It may occur in the ambulatory as well as the impatient setting. Every evaluation of a hyperkalemic patient should include a careful review of medications to determine if a drug capable of causing or aggra
Leaving no element of doubt: analysis of proteins using microPIXE.: Structure Fold Des. 1999 Dec 15;7(12):R291-9. Unique Identifier : AIDSLINE MED/20113472; Garman E; Department of Biochemistry, University of Oxford, UK.; elspeth@biop.ox.ac.uk
Anchoring an extended HTLV-1 Rex peptide within an RNA major groove containing junctional base triples.: Structure Fold Des. 1999 Dec 15;7(12):1461-72. Unique Identifier : AIDSLINE PDB/1C4J; Jiang F; Gorin A; Hu W; Majumdar A; Baskerville S; Xu W; Ellington A; Patel DJ; Cellular Biochemistry and Biophysics Program, Memorial; Sloan-Kettering Cancer Center, New York, NY 10021, USA.; BACKGROUND: The Rex protein of the human T cell leukemia virus type 1 (HTLV-1) belongs to a family of proteins that use arginine-rich motifs (ARMs) to recognize their RNA targets. Previously, an in vitro selected RNA aptamer sequence was identified that mediates mRNA transport in vivo when placed in the primary bindin
[A case of anti-GM1 antibody positive HTLV-I associated myelopathy (HAM) with polyneuropathy]: Rinsho Shinkeigaku. 1999 Sep;39(9):971-5. Unique Identifier : AIDSLINE MED/20081232; Yanagihara C; Ihara M; Nishimura Y; Oka N; Department of Neurology, Nishi-Kobe Medical Center, Kobe, Japan.; We report a case of HTLV-I associated myelopathy (HAM) with polyneuropathy. A 59-year old man suffering from progressive paraparesis associated with subclinical polyneuropathy was admitted to our hospital. HTLV-I antibodies in the serum and CSF were positive, and a diagnosis of HAM was made. His laboratory investigati
Antibodies from HIV-positive and AIDS patients bind to an HIV envelope multivalent vaccine.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):317-24. Unique Identifier : AIDSLINE MED/20097658; Carlos MP; Yamamura Y; Diaz-Mitoma F; Torres JV; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis 95616, USA.; A major problem impeding development of an effective HIV vaccine is the rapid antigenic variability that is characteristic of several envelope glycoprotein epitopes. Frequent mutations alter the composition of the most immunogenic regions of the envelope glycoprotein. We have prepared a synthetic immunogen representin
Presence of multiple HIV subtypes and a high frequency of subtype chimeric viruses in heterosexually infected women.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):325-32. Unique Identifier : AIDSLINE GENBANK/AF191348; Iversen AK; Learn GH; Fugger L; Gerstoft J; Mullins JI; Skinhoj P; Department of Infectious Diseases, Rigshospitalet, The National; University Hospital, Copenhagen, Denmark. aifrhm@inet.uni2.dk; The HIV-1 subtype distribution was determined in 41 HIV-positive women (-8% of all HIV-infected women in Denmark ) belonging to different risk groups. HIV p17 gag and env gene subtypes were determined by DNA sequence analysis. Five d
Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) infection in men receiving treatment for HIV-1 infection.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):333-40. Unique Identifier : AIDSLINE MED/20097660; Campbell TB; Fitzpatrick L; MaWhinney S; Zhang X; Schooley RT; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA.; OBJECTIVE: To determine the prevalence of human herpesvirus 8 (HHV-8) infection in men treated for HIV-1 infection in Denver, Colorado. DESIGN: Cross-sectional analysis METHODS: Blood samples were obtained from 216 HIV-1-infected men. Antibody to latency-associated nuclear antigen (LANA) was detected by an immunofluor
Delayed-type hypersensitivity to recombinant HIV envelope glycoprotein (rgp160) after immunization with homologous antigen.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):341-7. Unique Identifier : AIDSLINE MED/20097661; Katzenstein DA; Kundu S; Spritzler J; Smoller BR; Haszlett P; Valentine F; Merigan TC; Stanford University Center for AIDS Research, California 94305,; USA.; Delayed-type hypersensitivity (DTH) responses to intradermal recombinant HIV envelope glycoprotein (rgp160) may assess cell-mediated immune responses to HIV envelope. In three studies, DTH and lymphocyte proliferation responses to rgp160 were obtained in a total of 106 HIV-seropositive subjects with CD4+ counts >400 c
A multicenter, randomized, controlled trial of three preparations of low-dose oral alpha-interferon in HIV-infected patients with CD4+ counts between 50 and 350 cells/mm(3). Division of AIDS Treatment Research Initiative (DATRI) 022 Study Group.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):348-57. Unique Identifier : AIDSLINE MED/20097662; Alston B; Ellenberg JH; Standiford HC; Muth K; Martinez A; Greaves W; Kumi J; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892-7624, USA. BA27E@NIH.GOV; To evaluate the effectiveness of low-dose oral alpha-interferon (alpha-IFN), 247 HIV-infected study subjects received placebo, Alferon LDO, Veldona, or Ferimmune in a randomized, double-blind trial. Subjects had CD4+ counts between 50 and 350 cells/mm3 and HIV-related symptoms at entry. Study subjects rated the severi
Disease progression, adherence, and response to protease inhibitor therapy for HIV infection in an Urban Veterans Affairs Medical Center.: Unique Identifier : AIDSLINE MED/20097663; Maher K; Klimas N; Fletcher MA; Cohen V; Maggio CM; Triplett J; Valenzuela R; Dickinson G; Pathology Service, Department of Veterans Affairs Medical Center,; Miami, Florida, USA.; Indinavir therapy has demonstrated promise in the treatment of HIV-1 infection in clinical trials; however, its efficacy in a U.S. Veterans Affairs Medical Center, where access to therapy is generally unimpeded, is unknown. A review of the Miami cohor
Detection of distinct patterns of anti-tat antibodies in HIV-infected individuals with or without Kaposi's sarcoma.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):364-8. Unique Identifier : AIDSLINE MED/20097664; Demirhan I; Chandra A; Hasselmayer O; Biberfeld P; Chandra P; Department of Molecular Biology, Gustav-Embden Center of; Biological Chemistry, Frankfurt University Medical School,; Germany.; Patterns of antibody response to recombinant transactivator protein (HIV-1 tat) in serum samples from HIV-1-negative persons (n = 60), HIV-1-infected asymptomatic persons (n = 20), HIV-1-infected people with Kaposi s sarcoma (n = 25) and of people with Kaposi s sarcoma without HIV-1 infection have been analyzed. None
A comparison of exposure groups in the EuroSIDA study: starting highly active antiretroviral therapy (HAART), response to HAART, and survival.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):369-78. Unique Identifier : AIDSLINE MED/20097665; Mocroft A; Madge S; Johnson AM; Lazzarin A; Clumeck N; Goebel FD; Viard JP; Gatell J; Blaxhult A; Lundgren JD; Royal Free Centre for HIV Medicine, Royal Free and University; College Medical School, London, England. amanda@rfhsm.ac.uk; BACKGROUND: Concerns have been raised that intravenous drug users may be less likely to start highly active antiretroviral therapy (HAART) and that adherence to therapy may be poor among this group of patients. Given the decreased mortality and incidence of AIDS-defining illnesses among patients with HIV who start HAA
Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):379-85. Unique Identifier : AIDSLINE MED/20097666; Wabwire-Mangen F; Gray RH; Mmiro FA; Ndugwa C; Abramowsky C; Wabinga H; Whalen C; Li C; Saah AJ; Institute of Public Health, Makerere University, Kampala, Uganda.; Prospective follow-up of 172 HIV-infected pregnant women and their infants was conducted at Mulago Hospital, Kampala, Uganda during 1990 to 1992. Information was collected on maternal immune status (CD4 counts or clinical AIDS), and concurrent infections with sexually transmitted d
Virologic, immunologic, and immune activation markers as predictors of HIV-associated weight loss prior to AIDS. Multicenter AIDS Cohort Study.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):386-94. Unique Identifier : AIDSLINE MED/20097667; Lyles RH; Tang AM; Smit E; Mellors JW; Margolick JB; Visscher BR; Phair JP; Graham NM; Emory University, Atlanta, Georgia, USA.; OBJECTIVES: To study weight patterns among HIV-positive men and associations of baseline HIV RNA, CD4+ lymphocyte count, and serum levels of neopterin and beta2-microglobulin with subsequent weight loss prior to AIDS. METHODS: A cohort of 1558 homosexual men from the Multicenter AIDS Cohort Study comprised the main st
Rates of receiving HIV test results: data from the U.S. National Health Interview Survey for 1994 and 1995.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):395-400. Unique Identifier : AIDSLINE MED/20097668; Tao G; Branson BM; Kassler WJ; Cohen RA; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention (CDC), Atlanta, Georgia 30333,; USA.; OBJECTIVE: To determine the frequency and predictors of receipt of HIV test results. METHODS: Analysis of responses from 19,127 adults in 1994 and 16,848 in 1995 surveyed for the U.S. National Health Interview Survey, using logit models to determine factors independently associated with decreased likelihood of receivi
Drug resistance mutations among HIV-1 strains from antiretroviral-naive patients in Martinique, French West Indies.: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):401-5. Unique Identifier : AIDSLINE MED/20097669; Cesaire R; Dos Santos G; Abel S; Bera O; Sobesky G; Cabie A; L'Etablissement de Transfusion Sanguine, Centre Hospitalier et; Universitaire de Fort-de-France, Martinique.; We report on the frequency of genetic mutations associated with drug resistance in antiretroviral treatment-naive patients from Martinique (French West Indies), where zidovudine (ZDV) has been available since 1987 and where
Abacavir in combination with the inosine monophosphate dehydrogenase (IMPDH)-inhibitor mycophenolic acid is active against multidrug-resistant HIV-1 [letter]: Unique Identifier : AIDSLINE MED/20097670; Heredia A; Margolis D; Oldach D; Hazen R; Le N; Redfield R
HAART is effective as anti-Kaposi's sarcoma therapy only after remission has been induced by chemotherapy [letter]: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):407-8. Unique Identifier : AIDSLINE MED/20097671; Vaccher E; di Gennaro G; Nasti G; Juzbasic S; Tirelli U
Influence of seasonal variation with enteric microsporidiosis among HIV-infected individuals [letter]: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):408-9. Unique Identifier : AIDSLINE MED/20097672; Kopicko JJ; Frazer T; Dascomb K; Clark R; Didier ES; Kissinger P
Seroprevalence of HTLV-I in Cheju Island, a Korean island adjacent to the endemic area of Japan [letter]: J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):409-12. Unique Identifier : AIDSLINE MED/20097673; Kim JM; Chang KH; Choi YH; Song YG; Kang SM; Yoon TY; Choi JM; Park SY; Lew DJ
Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.: Clin Sci (Colch). 1999 Dec;97(6):707-18. Unique Identifier : AIDSLINE MED/20054202; Price DA; O'callaghan CA; Whelan JA; Easterbrook PJ; Phillips RE; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, Oxford OX3 9DU, U.K. dprice@worf.molbiol.ox.ac.uk; Efforts to develop immune-based therapies for HIV infection have been impeded by incomplete definition of the immunological correlates of protection. Despite many precedents demonstrating that CD8(+) cytotoxic T lymphocytes are key mediators of protective anti-viral immunity in non-human animal models, direct evidence
Clinico-laboratory characteristics of patients with dermatomyositis accompanied by rapidly progressive interstitial lung disease.: Clin Rheumatol. 1999;18(6):462-7. Unique Identifier : AIDSLINE MED/20102309; Ito M; Kaise S; Suzuki S; Kazuta Y; Sato Y; Miyata M; Nishimaki T; Nakamura N; Kasukawa R; Department of Internal Medicine II, Fukushima Medical University; School of Medicine, Fukushima City, Japan.; The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n = 7) and those with chronic interstitial lung disease (C-ILD, n = 9), and also between deceased (seven RP-ILD and three C-ILD) and living pa
Population structure of pathogens: the role of immune selection.: Parasitol Today. 1999 Dec;15(12):497-501. Unique Identifier : AIDSLINE MED/20038273; Gupta S; Anderson RM; Wellcome Trust Centre for the Epidemiology of Infectious Disease; in the Department of Zoology, University of Oxford, South Parks; Road, Oxford, UK OX1 3PS. sunetra.gupta@zoology.ox.ac.uk; Sunetra Gupta and Roy Anderson discuss how the balance between host immune responses against conserved and variable antigens shapes the population structure of pathogens. At one extreme, immune selection against polymorphic determinants can cause pathogen populations to self-organize spontaneously into discrete antige
Immunolocalization of IL-1beta and IL-6 in optic nerves of patients with AIDS.: Curr Eye Res. 1999 Sep;19(3):264-8. Unique Identifier : AIDSLINE MED/99418970; Saadati HG; Khan IA; Lin XH; Kadakia AB; Heller KB; Sadun AA; University of Southern California School of Medicine Doheny Eye; Institute Department of Ophthalmology, Los Angeles 90033, USA.; PURPOSE. Immunohistochemical procedures were employed to test the hypothesis that cytokines such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are involved in AIDS-related optic neuropathy and to determine the primary cell types involved. METHODS. Fixed sections of six human HIV-1 infected optic nerves were
Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis.: Dig Dis Sci. 1999 Dec;44(12):2530-7. Unique Identifier : AIDSLINE MED/20094204; Perez-Machado MA; Espinosa LM; de la Madrigal EJ; Abreu L; Lorente GM; Alvarez-Mon M; University Department of Paediatric Gastroenterology, Royal Free; Hospital, London, UK.; An abnormal immune response may play a pathogenic role in ulcerative colitis (UC). Animal models suggest that T-cell regulation may be of central importance in the inflammatory process. Our aims were the characterization of the phenotype and functional status of circulating T-cells in ulcerative colitis patients and t
Host cyclophilin A mediates HIV-1 attachment to target cells via heparans.: EMBO J. 1999 Dec 1;18(23):6771-85. Unique Identifier : AIDSLINE MED/20050571; Saphire AC; Bobardt MD; Gallay PA; Department of Immunology IMM-9, The Scripps Research Institute,; 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; The present study proposes a novel mode of action for cyclophilin A (CypA) in the HIV-1 life cycle. We demonstrate that CypA-deficient viruses do not replicate because they fail to attach to target cells. We show that CypA is exposed at the viral membrane and mediates HIV-1 attachment. We identify heparan as the exclu
Circular dichroism and fluorescence spectroscopic properties of the major core protein of feline immunodeficiency virus and its tryptophan mutants. Assignment of the individual contribution of the aromatic sidechains.: Eur J Biochem. 1999 Dec;266(3):1081-9. Unique Identifier : AIDSLINE MED/20050623; Yelamos B; Nunez E; Gomez-Gutierrez J; Datta M; Pacheco B; Peterson DL; Gavilanes F; Departamento de Bioquimica y Biologia Molecular I, Facultad de; Ciencias Quimicas, Universidad Complutense de Madrid, Spain.; The gene coding for the major capsid protein of feline immunodeficiency virus (FIV) has been cloned into the expression vector pQE60, which allows protein purification by affinity chromatography on a nitrilotriacetic acid/Ni/agarose column. The gene was expressed in Escherichia coli and the resultant soluble protein (
[Socioeconomic inequalities in health care efficacy. Three examples in Lazio region]: Epidemiol Prev. 1999 Jul-Sep;23(3):153-60. Unique Identifier : AIDSLINE MED/20073174; Rapiti E; Perucci CA; Agabiti N; Ancona C; Arca M; Di Lallo D; Forastiere F; Miceli M; Porta D; There has been a limited number of studies in Italy investigating the relationship between socioeconomic inequalities and efficacy of treatments. This paper reviews three case studies on the association between socioeconomic status and disease outcome in the Lazio Region, Italy. The
[Socioeconomic inequalities in health in the Tuscany Longitudinal Study (SLTO): persistence and changes over time in overall mortality and selected causes (lung cancer, liver cirrhosis, AIDS and overdose)]: Epidemiol Prev. 1999 Jul-Sep;23(3):207-14. Unique Identifier : AIDSLINE MED/20073179; Merler E; Benvenuti A; Baldi P; Nardulli MC; Olmastroni L; Biggeri A; Marchi M; Dreassi E; Unita Operativa di Epidemiologia, Azienda Ospedaliera Careggi,; Firenze.; We evaluate the persistence of social inequalities in overall mortality or mortality by causes (lung cancer, liver cirrhosis; AIDS and overdose) in the Tuscany Longitudinal Study (SLTo), a record linkage-study on the census population identified at the 1981 and 1991 censuses in Leghorn (1981: 175,741 subjects; 1991: 1
The effectiveness of condoms in reducing heterosexual transmission of HIV.: Fam Plann Perspect. 1999 Nov-Dec;31(6):272-9. Unique Identifier : AIDSLINE MED/20080154; Davis KR; Weller SC; Department of Preventive Medicine and Community Health, the; University of Texas Medical Branch, Galveston, USA.; CONTEXT: It is not established whether the condom is as effective at preventing heterosexual transmission of HIV as it is for preventing conception. An overall estimate of condom effectiveness for HIV prevention is needed. METHODS: Information on condom usage and HIV serology was obtained from 25 published studies of
Reproductive health and intimate partner violence.: Fam Plann Perspect. 1999 Nov-Dec;31(6):302-6. Unique Identifier : AIDSLINE MED/20080158; Moore M
Targeting of HIV gp120 by oligonucleotide-photosensitizer conjugates. Light-induced damages.: FEBS Lett. 1999 Dec 3;462(3):467-71. Unique Identifier : AIDSLINE MED/20086459; Vever-Bizet C; Boutorine AS; Delgado O; Brault D; Helene C; Laboratoire de Photobiologie, Museum National d'Histoire; Naturelle, INSERM U 201, CNRS UMR 8646, Paris, France.; Some guanine-rich oligonucleotides inhibit HIV infectivity through interaction with the gp120 glycoprotein. Besides, photoinactivation of viruses attracts attention for blood decontamination. The feasibility of targeting a red light-absorbing chlorin-type photosensitizer to gp120 through covalent coupling with 8-mer p
Primary response of naive CD4(+) T cells to amino acid-substituted analogs of an antigenic peptide can show distinct activation patterns: Th1- and Th2-type cytokine secretion, and helper activity for antibody production without apparent cytokine secretion.: FEBS Lett. 2000 Jan 7;465(1):28-33. Unique Identifier : AIDSLINE MED/20088793; Ise W; Totsuka M; Takato R; Hachimura S; Sato T; Ametani A; Kumagai Y; Habu S; Kaminogawa S; Department of Applied Biological Chemistry, The University of; Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.; Naive CD4(+) T cells differentiate into two types of helper T cells showing an interferon-gamma-predominant (Th1) or an interleukin-4-predominant (Th2) cytokine secretion profile after repeated antigenic stimulation. Their differentiation can be influenced by slight differences in the interaction between the T cell re
Management of ocular manifestations in patients with acquired immunodeficiency syndrome.: Dev Ophthalmol. 1999;31:192-209. Unique Identifier : AIDSLINE MED/20105963; Pivetti-Pezzi P; Accorinti M; Servizio Speciale di Immunovirologia Oculare, Universita di Roma; La Sapienza, Roma, Italia. uveiti.piv.@iol.it
Risk factors for cervical squamous intraepithelial lesions among HIV-1 seropositive women in Dar es Salaam, Tanzania.: Int J Gynaecol Obstet. 1999 Nov;67(2):87-94. Unique Identifier : AIDSLINE MED/20100007; Kapiga SH; Msamanga GI; Spiegelman D; Mwakyoma H; Fawzi WW; Hunter DJ; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; OBJECTIVES: To determine the prevalence and risk factors for cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Dar es Salaam, Tanzania . METHODS: Between July 1996 and December 1997 we interviewed 691 HIV-infected women to obtain information about risk fa
The use of paclitaxel and cisplatin in a patient with epithelial ovarian cancer and human immunodeficiency virus.: Gynecol Oncol. 2000 Jan;76(1):118-22. Unique Identifier : AIDSLINE MED/20088869; Knox SN; Robinson JB; Im DD; Logan L; Rosenshein NB; Department of Obstetrics, Gynecology, and the Reproductive; Sciences, University of Maryland Medical Systems, Baltimore,; Maryland, 21201, USA.; OBJECTIVE: Several spots exist of human immunodeficiency virus (HIV)-positive patients developing epithelial ovarian cancer. The optimal chemotherapeutic regimen has been unclear due to potential immunotoxicity from chemotherapy in these already immunocompromised patients. This is the first report of paclitaxel-based
E-Cadherin and CD44 expression in cervical intraepithelial neoplasia: comparison between HIV-positive and HIV-negative women and correlation with HPV status.: Gynecol Oncol. 2000 Jan;76(1):56-62. Unique Identifier : AIDSLINE MED/20088858; Darai E; Walker-Combrouze F; Benifla JL; Henin D; Feldmann G; Madelenat P; Scoazec JY; Service de Gynecologie, Hopital Bichat-Claude Bernard, Paris.; AIMS: We aimed to compare the expression patterns of E-cadherin and CD44 isoforms in cervical intraepithelial neoplasia (CIN) between patients with or without infection by the human immunodeficiency virus (HIV). METHODS: An immunohistochemical analysis using the monoclonal antibody HECD-1 against E-cadherin and the mo
The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice.: Immunology. 1999 Dec;98(4):510-9. Unique Identifier : AIDSLINE MED/20062755; Igietseme JU; Ananaba GA; Bolier J; Bowers S; Moore T; Belay T; Lyn D; Black CM; Department of Microbiology, Morehouse School of Medicine, Spelman; College, Atlanta, GA, USA.; Recent studies in animal models of genital chlamydial disease revealed that early recruitment of dendritic cells and specific T helper type-1 (Th1) cells into the genital mucosae is crucial for reducing the severity of the acute phase of a cervico-vaginal infection and arresting ascending disease. These immune effecto
Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization.: Immunology. 1999 Dec;98(4):519-24. Unique Identifier : AIDSLINE MED/20062756; Aoki I; Itoh S; Yokota S; Tanaka S; Ishii N; Okuda K; Minami M; Klinman DM; Department of Pathology, Yokohama City University School of; Medicine, Yokohama, Japan.; This work examines the contribution of mast cells to the synergistic enhancement of the T helper 2 (Th2) immune response elicited following simultaneous oral and subcutaneous (s.c.) immunization. The s.c. route induced a Th1-biased immune response, characterized by increased interferon-gamma (IFN-gamma) and immunoglob
Schistosomal egg antigen-responsive CD8 T-cell population in Schistosoma mansoni-infected BALB/c mice.: Immunology. 1999 Dec;98(4):525-34. Unique Identifier : AIDSLINE MED/20062757; Pancre V; Delacre M; Herno J; Auriault C; Laboratoire dImmunopathologie cellulaire des maladies; infectieuses, Lille, France,; We demonstrated here that schistosomal egg antigen (SEA) is able to stimulate an antigen-specific, cytotoxic CD8+ T-cell response in mice. Indeed, a single i.p. immunization with SEA resulted in the in vivo induction of significant cytotoxic T lymphocyte (CTL) activity in the spleen within 20 days. Effector cells were
Effects of alpha-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Valpha24+ Vbeta11+ T cells.: Immunology. 1999 Dec;98(4):557-63. Unique Identifier : AIDSLINE MED/20062761; Van Der Vliet HJ; Nishi N; Koezuka Y; Peyrat MA; Von Blomberg BM; Van Den Eertwegh AJ; Pinedo HM; Giaccone G; Scheper RJ; Department of Medical Oncology, University Hospital Vrije; Universiteit, Amsterdam, The Netherlands.; The alpha-galactosylceramide KRN7000 was reported to be presented by CD1d to natural killer (NK) T cells, cells that are thought to play an important role in the rejection of malignant tumours and in the regulation of several autoimmune diseases. Here we analysed human peripheral blood (PB) NK T cells (Valpha24+ Vbeta
Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats.: Immunology. 1999 Dec;98(4):590-4. Unique Identifier : AIDSLINE MED/20062766; Jung CG; Kamiyama T; Agui T; Center for Experimental Animal Science, Nagoya City University; Medical School, Nagoya, Japan.; Thymocytes and peripheral lymphocytes of BioBreeding (BB) diabetes-prone (BBDP) and diabetes-resistant (BBDR) rat were analysed by fluorescence-activated cell sorter (FACS). The number of CD4- CD8-, CD4+ CD8-, CD4- CD8+ and CD4+ CD8+ subsets was not different between BBDP and BBDR rat thymocytes, whereas spleen and ly
Mice transgenic for a soluble form of murine cytotoxic T lymphocyte antigen 4 are refractory to murine acquired immune deficiency sydrome development.: Unique Identifier : AIDSLINE MED/20062771; De Leval L; Debrus S; Lane P; Boniver J; Moutschen M; Laboratory of Pathology, University of Liege, Liege, Belgium.; Interactions between B and CD4+ T cells are central to the pathogenesis of retrovirus-induced murine acquired immune deficiency virus (MAIDS). Prompted by previous work showing that treatment with cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) partly inhibited the disease, we studied the course of infection
Tuberculosis in Europe at the end of the second millennium [editorial; comment]: Infection. 1999 Nov-Dec;27(6):311-2. Unique Identifier : AIDSLINE MED/20089714; Ruef C
Infection of the central nervous system by Mycobacterium tuberculosis in patients infected with human immunodeficiency virus (the new neurotuberculosis).: Infection. 1999 Nov-Dec;27(6):313-7. Unique Identifier : AIDSLINE MED/20089715; Sanchez-Portocarrero J; Perez-Cecilia E; Romero-Vivas J; Department of Medicine, Faculty of Health Sciences, European; University of Madrid, Spain. jorge.sanchez@ema.cisa.uem.es; Neurologic complications of HIV infection are numerous. This review focuses on the clinical presentation, diagnostic particularities and therapeutic issues of neurotuberculosis. The pertinent literature describing this important infection is succinctly summarized with a particular emphasis on the discussion of differe
Epidemiological study of tuberculosis in Palermo, Italy: IS6110 fingerprinting of Mycobacterium tuberculosis strains isolated in the years 1994-1998 [see comments]: Infection. 1999 Nov-Dec;27(6):318-22. Unique Identifier : AIDSLINE MED/20089716; Nastasi A; Mammina C; Medical School, Department of Hygiene and Microbiology G.; D'Alessandro, Palermo, Italy. diptigmi@mbox.unipa.it; In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of
Molecular epidemiology of tuberculosis among HIV-infected persons in Switzerland: a countrywide 9-year cohort study. Swiss HIV Cohort Study [see comments]: Infection. 1999 Nov-Dec;27(6):323-30. Unique Identifier : AIDSLINE MED/20089717; Sudre P; Pfyffer GE; Bodmer T; Prod'hom G; Furrer H; Bassetti S; Bernasconi E; Matter L; Telenti A; Strassle A; Jacques JP; Weber R; University Hospital, Geneva. PHILIPPE.SUDRE@HOSPVD.CH; We investigated tuberculosis transmission during a nine-year period (1988-1996) in a countrywide community-based cohort of HIV-infected persons in Switzerland (the Swiss HIV Cohort Study [SHCS]). We estimated the proportion of tuberculosis cases due to reinfection and relapse,
Negative predictors of survival in HIV-infected patients with culture-confirmed pulmonary tuberculosis.: Infection. 1999 Nov-Dec;27(6):331-4. Unique Identifier : AIDSLINE MED/20089718; Palmieri F; Pellicelli AM; Girardi E; De Felici AP; De Mori P; Petrosillo N; Ippolito G; II Divisione IRCCS L. Spallanzani, Rome, Italy.; f.palmieri@flashnet.it; We performed a retrospective study based on chart review of 118 HIV-infected patients with culture-confirmed pulmonary TB, in which M. tuberculosis isolates were tested for drug susceptibility. Patients were enrolled in the period January 1987 to December 1996 and followed until September 1997. The median survival for
Detection and genetic polymorphism of human herpes virus type 8 in endemic or epidemic Kaposi's sarcoma from West and Central Africa, and South America.: Int J Cancer. 2000 Jan 15;85(2):166-70. Unique Identifier : AIDSLINE MED/20094791; Fouchard N; Lacoste V; Couppie P; Develoux M; Mauclere P; Michel P; Herve V; Pradinaud R; Bestetti G; Huerre M; Tekaia F; de The G; Gessain A; Unite d'Epidemiologie des Virus Oncogenes, Departement SIDA; et Retrovirus, Institut Pasteur, Paris, France.; Kaposi s-sarcoma-associated herpesvirus(KSHV)/human-herpes-virus-8(HHV-8) sequences originally detected in AIDS-associated Kaposi s sarcoma have been found in almost every KS tested, whether endemic, classic, iatrogenic or epidemic. Most of the studies on African KS involved East African patients. We report herewith t
HPV-based cervical cancer screening in a population at high risk for HIV infection.: Int J Cancer. 2000 Jan 15;85(2):206-10. Unique Identifier : AIDSLINE MED/20094798; Womack SD; Chirenje ZM; Gaffikin L; Blumenthal PD; McGrath JA; Chipato T; Ngwalle S; Munjoma M; Shah KV; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, MD 21205-2179, USA. smizell@jhsph.edu; We determined the utility of an assay for 13 cancer-associated HPV types in primary cervical cancer screening of Zimbabwe women at high risk of HIV infection. HIV antibody status was determined by ELISA of oral mucosal specimens, and HPV DNA in the genital tract was identified by
A search for human herpesvirus 8 (HHV-8) in HIV-1 infected mothers and their infants does not suggest vertical transmission of HHV-8 [letter]: Int J Cancer. 2000 Jan 15;85(2):296-7. Unique Identifier : AIDSLINE MED/20094811; Calabro ML; Gasperini P; Barbierato M; Ometto L; Zanchetta M; De Rossi A; Chieco-Bianchi L
A study of HTLV-I infection and breast cancers in Trinidad and Tobago [letter]: Int J Cancer. 2000 Jan 15;85(2):298-9. Unique Identifier : AIDSLINE MED/20094812; Jack N; Edwards J; Dhanessar W; Benjamin H; Bartholomew C
[Immunosuppression caused by head and neck surgery]: HNO. 1999 Oct;47(10):885-92. Unique Identifier : AIDSLINE MED/20020106; Heimlich F; Dietz A; Daniel V; Maier H; Universitats-HNO-Klinik Heidelberg.; The immunomodulating effect of primary surgical intervention was investigated in 33 patients with squamous cell carcinomas of the oral cavity, pharynx and larynx. An operation time longer than 7 h was significantly associated with a decrease in lymphocytes, CD4(+) T-lymphocytes and CD8(+) T-lymphocytes. The CD4/CD8-ra
The role of human herpesvirus-8 in the pathogenesis of multiple myeloma.: Hematol Oncol Clin North Am. 1999 Dec;13(6):1159-67. Unique Identifier : AIDSLINE MED/20091587; Sjak-Shie NN; Vescio RA; Berenson JR; Division of Hematology and Oncology, University of California; School of Medicine, Los Angeles, USA.; Human herpesvirus-8 has been strongly implicated in the pathogenesis of KS, BCBL, and multicentric Castleman s disease. Evidence for its role in the pathogenesis of multiple myeloma is accumulating. Human herpesvirus-8 is detectable in the nonmalignant bone marrow dendritic cells from most myeloma patients. In additio
Letter urges access to sterile syringes [news]: J Ark Med Soc. 1999 Dec;96(7):243. Unique Identifier : AIDSLINE MED/20093604
Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.: J Biol Chem. 1999 Dec 3;274(49):34515-8. Unique Identifier : AIDSLINE MED/20044692; Matsuda S; Suzuki-Fujimoto T; Minowa A; Ueno H; Katamura K; Koyasu S; Department of Immunology, Keio University School of Medicine, 35; Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; CD8 deficiency is an autosomal recessive form of severe combined immunodeficiency diseases characterized by the absence of CD8(+) T lymphocytes and impaired T cell functions. We identified two novel mis-sense mutations in the zap70 genes of a CD8-deficiency patient. One mutation (P80Q) affects a residue in an SH2 doma
Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.: J Biol Chem. 1999 Dec 3;274(49):34719-27. Unique Identifier : AIDSLINE MED/20044722; Blanpain C; Doranz BJ; Vakili J; Rucker J; Govaerts C; Baik SS; Lorthioir O; Migeotte I; Libert F; Baleux F; Vassart G; Doms RW; Parmentier M; IRIBHN, Universite Libre de Bruxelles, Campus Erasme, 808 Route; de Lennik, B-1070 Bruxelles, Belgium.; CCR5 is a functional receptor for MIP-1alpha, MIP-1beta, RANTES (regulated on activation normal T cell expressed), MCP-2, and MCP-4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses. By using CCR5-CCR2b chimeras, we have shown previously that the second extracellular l
The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions.: J Biol Chem. 1999 Dec 3;274(49):34765-72. Unique Identifier : AIDSLINE MED/20044729; Foti M; Cartier L; Piguet V; Lew DP; Carpentier JL; Trono D; Krause KH; Department of Morphology, Geneva Medical School, University of; Geneva, CH-1225 Geneva, Switzerland.; Human immunodeficiency virus Nef plays an important role in AIDS pathogenesis. In addition to the well known down-regulation of cell surface receptors (CD4, MHCI), Nef is able to alter cellular signaling. Of particular interest for this study is the ability of Nef to bind with a very high affinity to SH3 domains of my
Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions.: J Biol Chem. 1999 Dec 3;274(49):34911-5. Unique Identifier : AIDSLINE MED/20044748; Tarasova NI; Rice WG; Michejda CJ; Molecular Aspects of Drug Design Section, ABL-Basic Research; Program, NCI-Frederick Cancer Research and Development Center,; Frederick, Maryland 21702, USA. Tarasova@ncifcrf.gov; G-protein-coupled receptors (GPCR) represent a superfamily of proteins that mediate the function of neurotransmitters and peptide hormones and are involved in viral entry and perception of light, smell, and taste. GPCRs are characterized by the presence of seven transmembrane domains (TMs). We demonstrate here that st
p56(lck), ZAP-70, SLP-76, and calcium-regulated effectors are involved in NF-kappaB activation by bisperoxovanadium phosphotyrosyl phosphatase inhibitors in human T cells.: J Biol Chem. 1999 Dec 3;274(49):35029-36. Unique Identifier : AIDSLINE MED/20044764; Ouellet M; Barbeau B; Tremblay MJ; Centre de Recherche en Infectiologie, Centre Hospitalier; Universitaire du Quebec, Pavillon CHUL and Departement de; Biologie Medicale, Faculte de Medecine, Universite Laval,; Sainte-Foy Quebec G1V 4G2, Canada.; This study investigates the second messengers involved in NF-kappaB activation by the bisperoxovanadium (bpV) phosphotyrosyl phosphatase inhibitors. We first initiated a time course analysis of bpV-mediated activation of the human immunodeficiency virus type-1 long terminal repeat- and NF-kappaB-driven reporter gene.
Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.: J Biol Chem. 1999 Dec 3;274(49):35119-28. Unique Identifier : AIDSLINE MED/20044777; Zapata DA; Pacheco-Castro A; Torres PS; Ramiro AR; Jose ES; Alarcon B; Alibaud L; Rubin B; Toribio ML; Regueiro JR; Inmunologia, Facultad de Medicina, Universidad Complutense,; 28040 Madrid, Spain.; Mature CD4(+) and CD8(+) T lymphocytes are believed to build and express essentially identical surface alphabeta T-cell receptor-CD3 (TCR.CD3) complexes. However, TCR.CD3 expression has been shown to be more impaired in CD8(+) cells than in CD4(+) cells when CD3gamma is absent in humans or mice. We have addressed this
Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.: J Biol Chem. 2000 Jan 7;275(1):279-87. Unique Identifier : AIDSLINE MED/20085043; O'Keeffe B; Fong Y; Chen D; Zhou S; Zhou Q; Department of Molecular Biology, University of California at; Berkeley, Berkeley, California 94720-3206, USA.; Tat activation of HIV-1 transcription is mediated by human transcription elongation factor P-TEFb, which interacts with Tat and phosphorylates the C-terminal domain of RNA polymerase II. The catalytic subunit of the P-TEFb complex, Cdk9, has been shown to interact with cyclin T and several other proteins of unknown id
Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.: J Biol Chem. 2000 Jan 7;275(1):359-66. Unique Identifier : AIDSLINE MED/20085053; Klarmann GJ; Smith RA; Schinazi RF; North TW; Preston BD; Department of Biochemistry, Eccles Institute of Human Genetics,; Salt Lake City, Utah 84112, USA.; Studies of drug-resistant reverse transcriptases (RTs) reveal the roles of specific structural elements and amino acids in polymerase function. To characterize better the effects of RT/template interactions on dNTP substrate recognition, we examined the sensitivity of human immunodeficiency virus type 1 (HIV-1) RT con
Nucleoprotein gene tracking: localization of specific HIV-1 genes to subchromatin nucleoprotein complexes containing endonuclease activity in HIV-1-infected human cells.: J Cell Biochem. 1999;Suppl 32-33:158-65. Unique Identifier : AIDSLINE MED/20094854; Nicolson NL; Nicolson GL; Institute for Molecular Medicine, Huntington Beach, California; 92649, USA.; We developed a technique with which to isolate specific subchromatin deoxyribonucleoprotein/ribonucleoprotein precursor complexes containing discrete genes from intact mammalian nuclei by direct restriction enzyme treatment with MspI. These nucleoprotein complexes can be further fractionated and purified by two-dimens
HIV-induced T-cell syncytia release a two component T-helper cell chemoattractant composed of Nef and Tat.: J Cell Sci. 1999 Nov;112 ( Pt 22):3931-41. Unique Identifier : AIDSLINE MED/20016349; Shutt DC; Soll DR; Department of Biological Sciences, University of Iowa, Iowa City,; Iowa 52242, USA.; Using a newly developed gradient chamber to provide independent measurements of chemokinesis (stimulated motility) and chemotaxis (stimulated motility up a concentration gradient) of individual T-helper cells, it was recently demonstrated that HIV-induced T-cell syncytia release two distinct chemotactic activities tha
Personality changes in an i.v. drug abuser.: Hosp Pract (Off Ed). 2000 Jan 15;35(1):27-30. Unique Identifier : AIDSLINE MED/20111455; Koche LS; Eisner T; Shah RP; Adelman HM; University of South Florida, James A. Haley Veterans Hospital,; Tampa, USA.
Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use.: J Clin Endocrinol Metab. 2000 Jan;85(1):35-41. Unique Identifier : AIDSLINE MED/20097826; Hadigan C; Corcoran C; Stanley T; Piecuch S; Klibanski A; Grinspoon S; Neuroendocrine Unit, Massachusetts General Hospital and Harvard; Medical School, Boston, 02114, USA.; Fat redistribution in the setting of protease inhibitor use is increasingly common and is associated with insulin resistance in human immunodeficiency virus (HIV)-infected patients. However, little is known regarding the factors that may contribute to abnormal insulin regulation in this population. We assessed fasting
Effects of hypogonadism and testosterone administration on depression indices in HIV-infected men.: J Clin Endocrinol Metab. 2000 Jan;85(1):60-5. Unique Identifier : AIDSLINE MED/20097830; Grinspoon S; Corcoran C; Stanley T; Baaj A; Basgoz N; Klibanski A; Neuroendocrine Unit, Massachusetts General Hospital and Harvard; Medical School, Boston 02114, USA.; Hypogonadism is prevalent among human immunodeficiency virus-infected men, in whom significantly reduced quality of life and mood disturbances have been reported. Previous studies have not investigated the relationship between depression score and gonadal function among such patients. We first compared depression scor
The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism.: J Clin Endocrinol Metab. 2000 Jan;85(1):66-70. Unique Identifier : AIDSLINE MED/20097831; Yesilova Z; Ozata M; Kocar IH; Turan M; Pekel A; Sengul A; Ozdemir IC; Department of Internal Medicine, Gulhane School of Medicine,; Etlik-Ankara, Turkey.; There is a significant line of evidence for a role of androgens in the modulation of the immune system. However, little is known about immunological features of male patients with idiopathic hypogonadotropic hypogonadism (IHH) and the potential effects of gonadotropin treatment. Thus, the objective of this study was t
CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP.: J Neuroimmunol. 2000 Jan 3;102(1):1-7. Unique Identifier : AIDSLINE MED/20090086; Matsuoka E; Usuku K; Jonosono M; Takenouchi N; Izumo S; Osame M; Division of Molecular Pathology and Genetic Epidemiology, Center; for Chronic Virus Diseases, Faculty of Medicine, Kagoshima; University, Japan.; Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu
CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS.: J Neuroimmunol. 2000 Jan 3;102(1):44-50. Unique Identifier : AIDSLINE MED/20090091; Becher B; Blain M; Antel JP; Department of Microbiology, Dartmouth Medical School, Lebanon, NH; 03576, USA. burkhard.becher@dartmouth.edu; The APC-derived cytokine interleukin (IL)-12 polarizes CD4 T cells towards the pro-inflammatory Th1 phenotype and has been shown to be crucial for the development of EAE in rodents. In this study we demonstrate that production of IL-12 by human adult CNS-derived microglial cells can be triggered by cell contact with a
Intrathecal immune activation is associated with cerebrospinal fluid markers of neuronal destruction in AIDS patients.: J Neuroimmunol. 2000 Jan 3;102(1):51-5. Unique Identifier : AIDSLINE MED/20090092; Hagberg L; Fuchs D; Rosengren L; Gisslen M; Department of Infectious Diseases, Goteborg University,; Sahlgrenska University Hospital, Sweden.; lars.hagberg@medfak.gu.se; We analysed the relationship between cerebrospinal fluid (CSF) concentrations of the light subunit of the neurofilament protein (NFL, a marker of neurons, mainly axons), neopterin (a marker of immune activation), and quantitative HIV RNA levels in 47 patients with HIV-1 infection, 25 of whom had AIDS. In the AIDS pati
Behavioral and psychological disorders in uninfected children aged 6 to 11 years born to human immunodeficiency virus-seropositive mothers.: Unique Identifier : AIDSLINE MED/20074049; Esposito S; Musetti L; Musetti MC; Tornaghi R; Corbella S; Massironi E; Marchisio P; Guareschi A; Principi N; Paediatric Department IV, University of Milan, Italy.; This study investigated the behavioral and psychological differences between 39 uninfected children born to human immunodeficiency virus (HIV)-seropositive mothers (HIV-seroreverter [SR]) and 78 children with no family history of HIV infection. Caretakers completed the Child Behavior Checklist and the Gittelman modifi
Cyclin D1 expression and HHV8 in Kaposi sarcoma.: J Clin Pathol. 1999 Aug;52(8):569-73. Unique Identifier : AIDSLINE MED/20109820; Kennedy MM; Biddolph S; Lucas SB; Howells DD; Picton S; McGee JO; Silva I; Uhlmann V; Luttich K; O'Leary JJ; Nuffield Department of Pathology and Bacteriology, University of; Oxford, UK.; BACKGROUND: Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins which are pivotal in cell cycle progression. Recent HHV8 genetic analysis has revealed the presence of a v-cyclin which
Protease inhibitor-associated angiolipomatosis.: J Am Acad Dermatol. 2000 Jan;42(1 Pt 1):129-31. Unique Identifier : AIDSLINE MED/20082911; Dank JP; Colven R; Department of Medicine, Division of Dermatology, University of; Washington-Harborview Medical Center, Seatle 98104, USA.; Treatment with protease inhibitors in some persons infected with HIV-1 is associated with a syndrome of lipodystrophy manifesting as peripheral lipoatrophy, relative central adiposity, insulin resistance, and serum lipid abnormalities. We report 3 cases of HIV-1 inf
[Cystoid macular edema and cytomegalovirus retinitis in AIDS patients treated with antiretroviral triple therapy]: J Fr Ophtalmol. 1999 Dec;22(10):1034-41. Unique Identifier : AIDSLINE MED/20085207; Badelon I; Gohier P; Chaine G; Service d'Ophtalmologie, Hopital Avicenne 125, route de; Stalingrad, 93009 Bobigny Cedex.; AIM OF THE STUDY: This study evaluated cystoid macular edema (CME) occurring during inactive cytomegalovirus ( CMV ) retinitis, in AIDS patients treated with highly active antiretroviral therapy (HAART) and without anti CMV tre
[Cytomegalovirus retinitis and ocular complications in AIDS patients in Togo]: J Fr Ophtalmol. 1999 Dec;22(10):1042-6. Unique Identifier : AIDSLINE MED/20085208; Balo KP; Amoussou YP; Bechetoille A; Mihluedo H; Djagnikpo PA; Akpandja SM; Banla M; Service d'Ophtalmologie, CHU Tokoin, Lome, Togo.; komibalo@syfed.tg.refer.org; BACKGROUND: Cytomegalovirus retinitis seems to be an uncommon complication in African AIDS patients. This study was conducted in 200 patients in order to evaluate AIDS eye related complications with specific focus to cytomegalovirus retinitis. MATERIAL AND METHODS: During a period
Effects of oral nutritional supplementation on the intestinal mucosa of patients with AIDS.: J Clin Gastroenterol. 1999 Jan;30(1):77-80. Unique Identifier : AIDSLINE MED/20100171; Fogaca H; Souza H; Carneiro AJ; Carvalho AT; Pimentel ML; Papelbaum M; Elia P; Elia C; Multidisciplinary Laboratory, University Hospital, Federal; University of Rio de Janeiro, Brazil.; Weight loss is a major component of the clinical syndrome in patients with acquired immunodeficiency syndrome (AIDS). The impact of malnutrition on the outcome of the disease has been unappreciated in many investigations. The authors evaluated the effects of oral nutritional supplementation on the morphology and immun
New approaches to screening for cervical cancer in high-risk populations [editorial; comment]: J Lab Clin Med. 2000 Jan;135(1):12-3. Unique Identifier : AIDSLINE MED/20102226; Miller DM; Castillos FA
Infrared spectroscopic study of cervical smears in patients with HIV: implications for cervical carcinogenesis [see comments]: J Lab Clin Med. 2000 Jan;135(1):26-31. Unique Identifier : AIDSLINE MED/20102229; Rigas B; LaGuardia K; Qiao L; Bhandare PS; Caputo T; Cohenford MA; Department of Medicine, Cornell University Medical College, New; York, New York, USA.; Patients with HIV have an increased incidence of cervical cancer, necessitating increased surveillance. Infrared spectroscopy (IRS) has the potential of aiding the diagnosis of cervical neoplasia and also of providing clues into its pathogenesis. We studied by IRS cervical scrapings from 22 HIV-infected and 23 control
Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice.: J Exp Med. 1999 Dec 20;190(12):1857-68. Unique Identifier : AIDSLINE MED/20069893; Dittmer D; Stoddart C; Renne R; Linquist-Stepps V; Moreno ME; Bare C; McCune JM; Ganem D; Department of Microbiology, University of California, San; Francisco, California 94143, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV/HHV-8) is a novel human lymphotropic herpesvirus linked to several human neoplasms. To date, no animal model for infection by this virus has been described. We have examined the susceptibility of C.B-17 scid/scid mice implanted with human fetal thymus and liver grafts (SCI
Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis.: J Nat Prod. 1999 Nov;62(11):1510-3. Unique Identifier : AIDSLINE MED/20048034; Yang XW; Zhao J; Cui YX; Liu XH; Ma CM; Hattori M; Zhang LH; National Laboratory of Natural and Biomimetic Drugs, Beijing; Medical University, Beijing 100083, People's Republic of China.; xwyang@mail.bjmu.edu.cn; Eight bioactive triterpenoid saponins (1-8) were isolated from the seeds of Aesculus chinensis, four of which are novel compounds. The major saponins were identified as escin Ia (1), Ib (2), isoescin Ia (3) and Ib (4), while the new compounds were identified as 22alpha-tigloyl-28-acetylprotoaescigenin-3beta-O-:beta D-
Increased cerebrospinal fluid protein tau concentration in neuro-AIDS.: J Neurol Sci. 1999 Dec 15;171(2):92-6. Unique Identifier : AIDSLINE MED/20050808; Andersson L; Blennow K; Fuchs D; Svennerholm B; Gisslen M; Institute of Internal Medicine, Department of Infectious; Diseases, Goteborg University, Sahlgrenska University Hospital,; S-416 85, Goteborg, Sweden. lars-magnus.andersson@medfak.gu.se; OBJECTIVES: Assessment of cerebrospinal fluid (CSF) levels of protein tau in human immunodeficiency virus type 1 (HIV-1) infection. MATERIAL AND METHODS: CSF tau levels were analyzed in 52 HIV-1-infected patients, 37 of whom had no neurological symptoms, eight had aquired immunodeficiency syndrome (AIDS)
Respiratory infections in patients with HIV.: J R Coll Physicians Lond. 1999 Sep-Oct;33(5):430-3. Unique Identifier : AIDSLINE MED/20089782; Breen R; Johnson M; Department of HIV and Thoracic Medicine, Royal Free Hospital,; London.
Cessation of antiretroviral therapy and rapid rebound of HIV.: J Natl Med Assoc. 1999 Dec;91(12):645-6. Unique Identifier : AIDSLINE MED/20093609
HIV post-exposure therapy for drug users in treatment.: J Subst Abuse Treat. 2000 Jan;18(1):17-21. Unique Identifier : AIDSLINE MED/20100557; O'Connor PG; Department of Internal Medicine and the Substance Abuse Treatment; Unit, Yale University School of Medicine, Primary Care Center and; Yale-New Haven Hospital, New Haven, CT 06520-8025, USA.; patrick.oconnor@yale.edu; The purpose of this study was to evaluate the attitudes of drug treatment program providers concerning human immunodeficiency virus (HIV) post-exposure therapy (PET) for drug users enrolled in drug treatment. This was a cross-sectional evaluation of drug treatment program providers in four methadone maintenance progra
Home sample collection for HIV testing [letter]: JAMA. 2000 Jan 12;283(2):198-9. Unique Identifier : AIDSLINE MED/20097796; Phillips KA; Morin S; Coates T; Fernyak S; Marsh A; Ramos-Irizarry L
Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. Trilege (Agence Nationale de Recherches sur le SIDA 072) Study Team) [see comments]: JAMA. 2000 Jan 12;283(2):205-11. Unique Identifier : AIDSLINE MED/20097802; Descamps D; Flandre P; Calvez V; Peytavin G; Meiffredy V; Collin G; Delaugerre C; Robert-Delmas S; Bazin B; Aboulker JP; Pialoux G; Raffi F; Brun-Vezinet F; Hopital Bichat-Claude Bernard, Paris, France.; CONTEXT: In the Trilege trial, following induction with a zidovudine, lamivudine, and indinavir regimen, human immunodeficiency virus (HIV) replication was less suppressed by 2-drug maintenance therapy than by triple-drug therapy. OBJECTIVE: To identify mechanisms of virologic failure in the 3 arms of the Trilege tria
Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens [see comments]: JAMA. 2000 Jan 12;283(2):229-34. Unique Identifier : AIDSLINE MED/20097805; Havlir DV; Hellmann NS; Petropoulos CJ; Whitcomb JM; Collier AC; Hirsch MS; Tebas P; Sommadossi JP; Richman DD; University of California, San Diego 92103, USA. dhavlir@ucsd.edu; CONTEXT: Loss of viral suppression in patients infected with human immunodeficiency virus (HIV), who are receiving potent antiretroviral therapy, has been attributed to outgrowth of drug-resistant virus; however, resistance patterns are not well characterized in patients whose protease inhibitor
Resistance, fitness, adherence, and potency: mapping the paths to virologic failure [editorial; comment]: JAMA. 2000 Jan 12;283(2):250-1. Unique Identifier : AIDSLINE MED/20097808; Markowitz M
[Factors for the onset of and the exacerbation of tuberculosis. 2. Host factors promoting the occurrence and exacerbation of tuberculosis: significance of Th1-Th2 cytokine balance]: Kekkaku. 1999 Oct;74(10):735-40. Unique Identifier : AIDSLINE MED/20030372; Kawakami K; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; The problem of tuberculosis is emerging again with increase in the population of aged people and immunocompromised patients in Japan . It has been well documented that cell-mediated immunity play a central role in host resistance to infection with Mycobacterium tuberculosis. A decade
[Factors for the onset of and the exacerbation of tuberculosis. 5. The infection and prognosis of tuberculosis among patients with immunodeficiency, especially HIV-infected patients]: Kekkaku. 1999 Oct;74(10):753-8. Unique Identifier : AIDSLINE MED/20030375; Nagai H; Department of Respiratory Diseases, National Tokyo Hospital,; Japan.; The number of people infected with human immunodeficiency virus (HIV) is gradually increasing in Japan , and the morbidity rate from tuberculosis in the Japanese people is high. Accordingly, the number of cases with both infections is considered to increase in the future. Our hospita
Second treatment with fludarabine in a Waldenstrom's macroglobulinemia patient [letter]: Leukemia. 2000 Jan;14(1):220. Unique Identifier : AIDSLINE MED/20105442; Maloisel F; Campos F; Giron C; Dufour P
Prevalence and predictors of unmet need for supportive services among HIV-infected persons: impact of case management.: Med Care. 2000 Jan;38(1):58-69. Unique Identifier : AIDSLINE MED/20094416; Katz MH; Cunningham WE; Mor V; Andersen RM; Kellogg T; Zierler S; Crystal SC; Stein MD; Cylar K; Bozzette SA; Shapiro MF; Department of Public Health, San Francisco, California, USA.; BACKGROUND: Previous research has indicated that the needs of persons infected with human immunodeficiency virus (HIV) for supportive services often go unmet. Although case management has been advocated as a method of decreasing unmet needs for supportive services, its effectiveness is poorly understood. OBJECTIVES: T
[What to do after accidental exposure to blood or other biological fluids in the health care medium]: Med Clin (Barc). 1999 Oct 30;113(14):544-8. Unique Identifier : AIDSLINE MED/20073606; Torres M; Campins M; Serra C; Martinez M; Bruguera M; Servicio de Medicina Interna, Hospital de l'Esperit Sant, Santa; Coloma de Gramenet, Barcelona.
[Cryoglobulinemia and hepatitis C virus infection in patients with monoclonal gammopathies (letter)]: Med Clin (Barc). 1999 Oct 30;113(14):558. Unique Identifier : AIDSLINE MED/20073611; Domingo JM; Soledad Romero M; Palomera L; Gutierrez M
[Inappropriate presentation of pharmaceutical forms of dosages in antiretroviral therapy (letter)]: Med Clin (Barc). 1999 Oct 30;113(14):559. Unique Identifier : AIDSLINE MED/20073612; Gonzalez Delgado M; Anton Torres R; Borras Blasco J; Ortiz de Urbina Sandomingo V
[Prognostic markers of survival in infants younger than 12 month of age vertically infected by human immunodeficiency virus]: Med Clin (Barc). 1999 Nov 6;113(15):561-6. Unique Identifier : AIDSLINE MED/20073613; Resino S; Jimenez JL; Gurbindo D; Munoz-Fernandez MA; Servicio de Inmunologia, Hospital General Universitario Gregorio; Maranon, Madrid.; OBJECTIVES: To assess the immunological and virological markers as potential predictors of progression to death in HIV-1 infected
[AIDS and children (editorial)]: Med Clin (Barc). 1999 Nov 6;113(15):575-7. Unique Identifier : AIDSLINE MED/20073616; Delgado Garcia-Campero A
[Many epoch-making discoveries--but also big misjudgements]: Lakartidningen. 1999 Dec 22;96(51-52):5744-52. Unique Identifier : AIDSLINE MED/20107871; Stolt CM; Humanistisk medicin, Karolinska institutet, Stockholm.
Using protein structural information in evolutionary inference: transmembrane proteins.: Mol Biol Evol. 1999 Dec;16(12):1696-710. Unique Identifier : AIDSLINE MED/20073038; Lio P; Goldman N; Department of Genetics, University of Cambridge, England.; We present a model of amino acid sequence evolution based on a hidden Markov model that extends to transmembrane proteins previous methods that incorporate protein structural information into phylogenetics. Our model aims to give a better understanding of processes of molecular evolution and to extract structural info
hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.: Mol Cell Biol. 1999 Oct;19(10):6833-44. Unique Identifier : AIDSLINE MED/99421967; Kim MK; Nikodem VM; Genetics and Biochemistry Branch, National Institute of Diabetes; and Digestive and Kidney Diseases, National Heart, Lung, and; Blood Institute, National Institutes of Health, Bethesda, MD; 20892, USA. kimm@gwgate.nhlbi.nih.gov; This study describes a potential new function of hnRNP U as an RNA polymerase (Pol II) elongation inhibitor. We demonstrated that a subfraction of human hnRNP U is associated with the Pol II holoenzyme in vivo and as such recruited to the promoter as part of the preinitiation complex. hnRNP U, however, appears to diss
Assessing the replicative history of human T cells [see comments]: Mutat Res. 1999 Dec 17;431(2):177-80. Unique Identifier : AIDSLINE MED/20101923; Van Lier RA; Baars PA; Department of Immunobiology, CLB, Academic Medical Centre,; Plesmanlaan, Amsterdam, Netherlands. r_van_lier@clb.nl; Upon encountering antigen, T cells clonally expand and differentiate into effector cells that directly or indirectly eliminate antigen-bearing pathogens. When renewed contact with the same pathogen occurs the immune response is mounted in a faster and more accurate way, a process that is referred to as immunological m
Transmission of Mycobacterium tuberculosis from a cadaver to an embalmer.: N Engl J Med. 2000 Jan 27;342(4):246-8. Unique Identifier : AIDSLINE MED/20098056; Sterling TR; Pope DS; Bishai WR; Harrington S; Gershon RR; Chaisson RE; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore City Health Department Eastern Chest; Clinic, MD, USA. tsterls@jhmi.edu
Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus.: Ophthalmology. 2000 Jan;107(1):159-63. Unique Identifier : AIDSLINE MED/20112261; Feinberg AS; Spraul CW; Holden JT; Grossniklaus HE; Department of Ophthalmology, Emory University School of Medicine,; Atlanta, Georgia, USA.; PURPOSE: To describe the clinicopathologic features of two patients with Epstein-Barr virus (EBV) associated conjunctival lymphocytic infiltrates. DESIGN: Two case reports. METHODS: The clinical histories and pathologic findings of two patients with salmon-colored conjunctival infiltrates are described. MAIN OUTCOME M
Green tea and its major components ameliorate immune dysfunction in mice bearing Lewis lung carcinoma and treated with the carcinogen NNK.: Nutr Cancer. 1999;35(1):64-72. Unique Identifier : AIDSLINE MED/20089834; Zhu M; Gong Y; Yang Z; Ge G; Han C; Chen J; Institute of Radiation Medicine, Beijing, China.; yfg268@nic.bmi.ac.cn; The protective effects of tea and/or its components on dysfunction of immune functions during tumor growth and carcinogenesis in mice were studied using two experimental models: C57/BL6J mice transplanted with Lewis lung carcinoma (LLC) and Kunming mice treated with a single dose of 4-(methylnitrosamino-)-1-(3-pyridyl
Concentration-dependent differential induction of necrosis or apoptosis by HIV-1 lytic peptide 1.: Peptides. 1999 Nov;20(11):1275-83. Unique Identifier : AIDSLINE MED/20077688; Plymale DR; Comardelle AM; Fermi CD; Martin DS; Costin JM; Norris CH; Tencza SB; Mietzner TA; Montelaro RC; Garry RF; Interdisciplinary Graduate Program in Molecular and Cellular; Biology, Tulane University, New Orleans, LA 70112, USA.; The mechanism by which human immunodeficiency virus type 1 induces depletion of CD4+ T-lymphocytes remains controversial, but may involve cytotoxic viral proteins. Synthetic peptides (lentivirus lytic peptide type 1) corresponding to the carboxyl terminus of the human immunodeficiency virus type 1 transmembrane glycop
Expression of cannabinoid receptors and their gene transcripts in human blood cells.: Prog Neuropsychopharmacol Biol Psychiatry. 1999 Aug;23(6):1063-77. Unique Identifier : AIDSLINE MED/20087830; Onaivi ES; Chaudhuri G; Abaci AS; Parker M; Manier DH; Martin PR; Hubbard JR; Department of Psychiatry, Vanderbilt University School of; Medicine, Nashville, TN, USA. Emmanuel.S.Onaivi@Vanderbilt.edu; 1. This study shows that the human cannabinoid receptors and their gene transcripts can be analyzed in blood samples when combined with polymerase chain reaction. The results also demonstrate that the expression of the cannabinoid receptors is dependent on gender and ethnic background. 2. Normal human volunteers who d
[Hyperlipidemia in patients with HIV infection treated with protease inhibitors (letter)]: Rev Clin Esp. 1999 Nov;199(11):780-1. Unique Identifier : AIDSLINE MED/20103608; Lopez Garcia F; Mora Rufete A; Escolano Hortelano CM; Gutierrez Rodero F
Pulmonary complications of HIV disease. Introduction.: Semin Respir Infect. 1999 Dec;14(4):299-300. Unique Identifier : AIDSLINE MED/20102046; Rosen MJ
Epidemiology and risk of pulmonary disease.: Semin Respir Infect. 1999 Dec;14(4):301-8. Unique Identifier : AIDSLINE MED/20102047; Rosen MJ; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, and Albert Einstein College of Medicine, New; York, New York 10003, USA.; Although pulmonary diseases are important causes of illness and death in patients with human immunodeficiency virus (HIV) infection, advances in treatment and the demographics of HIV-infected populations are changing their incidence and manifestations. The rates of acquires immune deficiency syndrome (AIDS)- related m
Screening and noninvasive testing for pulmonary disease.: Semin Respir Infect. 1999 Dec;14(4):309-17. Unique Identifier : AIDSLINE MED/20102048; Schneider RF; Medical Intensive Care Unit, Beth Israel Medical Center, Albert; Einstein College of Medicine, New York, New York 10003, USA.; Although detection of preclinical disease using screening tests is desirable if earlier treatment improves outcome, the available data show no morbidity or mortality benefit using chest radiography, sputum analysis for Pneumocystis carinii and acid-fast bacilli, or serial measurements of single-breath carbon monoxide
Bronchoscopic techniques for the diagnosis of pulmonary complications of HIV infection.: Semin Respir Infect. 1999 Dec;14(4):318-26. Unique Identifier : AIDSLINE MED/20102049; Salzman SH; Division of Pulmonary Critical Care Medicine, Beth Israel Medical; Center, Albert Einstein College of Medicine, New York, New York; 10003, USA.; Bronchoscopy has played the central role in defining the spectrum of pulmonary disorders that occur in patients with HIV infection. Transbronchial biopsy (TBB) and bronchoalveolar lavage (BAL) both have high yields in the diagnosis of Pneumocystis carinii pneumonia (PCP) and other infections. Paradoxically, despite ou
Bacterial pneumonia.: Semin Respir Infect. 1999 Dec;14(4):327-32. Unique Identifier : AIDSLINE MED/20102050; Schneider RF; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, Albert Einstein College of Medicine, New York,; New York 10003, USA.; Bacterial pneumonia is significantly more common in persons who are HIV-infected than in the general population and is most common among injection drug users and in persons with advanced HIV disease and immunosuppression. The clinical features of bacterial pneumonia are similar to those in HIV-seronegative persons, bu
Pneumocystis carinii pneumonia.: Semin Respir Infect. 1999 Dec;14(4):333-43. Unique Identifier : AIDSLINE MED/20102051; Schliep TC; Yarrish RL; Division of Infectious Diseases, Beth Israel Medical Center,; Albert Einstein College of Medicine, New York, New York 10003,; USA.; Throughout the epidemic, Pneumocystis carinii pneumonia (PCP) has been the most common AIDS-defining opportunistic infection in the United States . With the widespread use of highly active antiretroviral therapy (HAART) and prophylaxis in patients known to be at risk, the incidence of P
Tuberculosis in patients with human immunodeficiency virus infection.: Semin Respir Infect. 1999 Dec;14(4):344-52. Unique Identifier : AIDSLINE MED/20102052; Perlman DC; El-Helou P; Salomon N; AIDS Inpatient Unit, Beth Israel Medical Center, Albert Einstein; College of Medicine, New York, New York 10003, USA.; Tuberculosis (TB) is the major opportunistic infection of human immunodeficiency virus (HIV)-infected persons worldwide. Human immunodeficiency virus infection is the most potent known risk factor for reactivation of latent Mycobacterium tuberculosis infection, and TB disease appears to increase the rate of HIV progre
Cytomegalovirus pneumonia.: Semin Respir Infect. 1999 Dec;14(4):353-8. Unique Identifier : AIDSLINE MED/20102053; Salomon N; Perlman DC; Division of Infectious Diseases, Beth Israel Medical Center,; Albert Einstein College of Medicine, New York, New York 10003,; USA.; Cytomegalovirus ( CMV ) pneumonia is a major cause of morbidity and mortality in allogeneic bone marrow transplant and lung transplant recipients. However, its role as a cause of lung disease in patients with the human immunodeficiency virus (HIV) is controversial
Thoracic surgical spectrum of HIV infection.: Semin Respir Infect. 1999 Dec;14(4):359-65. Unique Identifier : AIDSLINE MED/20102054; Abolhoda A; Keller SM; Beth Israel Medical Center, Albert Einstein College of Medicine,; New York, New York 10003, USA.; The thoracic surgeon is often called on to diagnose or treat a variety of disorders associated with human immunodeficiency virus (HIV) infection. Surgical mediastinal exploration through cervical and anterior approaches is a safe and valuable modality in appropriately selected patients with unexplained mediastinal lym
Intensive care of patients with HIV infection.: Semin Respir Infect. 1999 Dec;14(4):366-71. Unique Identifier : AIDSLINE MED/20102055; Rosen MJ; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, Albert Einstein College of Medicine, New York,; New York 10003, USA.; Despite the improvements in the prognosis associated with the development of highly active antiretroviral therapy (HAART), more than 410,000 people in the United States were reported to have died from acquired immune deficiency syndrome (AIDS) by the end of 1998. The number of people l
Infection control in pulmonary and critical care medicine.: Semin Respir Infect. 1999 Dec;14(4):372-82. Unique Identifier : AIDSLINE MED/20102056; Raucher BG; Department of Infection Control, Beth Israel Medical Center, New; York, New York 10003, USA.; During the routine care of patients, pulmonary and critical care specialist may have significant exposure to respiratory infections and potentially infectious body fluids such as blood and pleural fluid. Bronchoscopy and intensive care services often require close contact with patients and the use of sharp devices req
[1977 mortality rate in HIV-infected patients presenting with hepatitis C cirrhosis. Results of the GERMIVC multicenter survey conducted in French departments of internal medicine or infectious disease]: Rev Med Interne. 1999 Dec;20(12):1082-7. Unique Identifier : AIDSLINE MED/20100986; Geffray L; Rosenthal E; Cacoub P; Perronne C; Veyssier P; Raguin G; Cevallos R; Patey O; Bouchard O; Loury I; Delarocque E; Goujard C; Estavoyer JM; Dupont C; Grappin M; Morand P; Laurichesse H; Vuitton D; Hopital de Compiegne, Nice, France.; PURPOSE: Hepatitis C (HCV) has a high prevalence (10-30%) among human immunodeficiency virus (HIV)-infected patients. However, little information is available regarding the impact of hepatitis C on survival. The objective of our study was to determine the incidence of hepatitis C-related deaths in HIV-HCV co-infected
[Pain in the left scapula]: Schweiz Rundsch Med Prax. 1999 Nov 18;88(47):1958-9. Unique Identifier : AIDSLINE MED/20073256; Guex AC; Departement Innere Medizin, Kantonsspital Basel.
[Diarrhea in HIV infection]: Schweiz Rundsch Med Prax. 1999 Dec 9;88(50):2081-2. Unique Identifier : AIDSLINE MED/20107939; Hansel A; Medizinische Universitats-Poliklinik Basel.
Histologic lesions in cynomolgus monkeys (Macaca fascicularis) naturally infected with simian retrovirus type D: comparison of seropositive, virus-positive, and uninfected animals.: Toxicol Pathol. 1999 Nov-Dec;27(6):672-7. Unique Identifier : AIDSLINE MED/20053769; Guzman RE; Kerlin RL; Zimmerman TE; Drug Safety Evaluation, Pfizer Central Research, Groton,; Connecticut 06340, USA. reguzman@students.uiuc.edu; Simian retrovirus (SRV) type D is a common cause of simian acquired immunodeficiency syndrome (SAIDS), a usually fatal immunosuppressive disease of macaques. Associated gross and histologic lesions have been well described for the rhesus macaque (Macaca mulatta) in experimental and natural infections. However, morphol
[Grotesque hepatomegaly in known HIV seropositivity]: Schweiz Med Wochenschr. 1999 Dec 4;129(48):1902. Unique Identifier : AIDSLINE MED/20093468; Sanna P; Spataro V; Fadini D; Cavalli F; Istituto Oncologico della Svizzera Italiana, Divisione di; Oncologia medica, Ospedale San Giovanni, Bellinzona.; oncosg@siak.ch
Of chimps and men [letter]: Science. 2000 Jan 14;287(5451):233. Unique Identifier : AIDSLINE MED/20119943; Hooper E
The last resort would be to go to the GP'. Understanding the perceptions and use of general practitioner services among people with HIV/AIDS.: Soc Sci Med. 2000 Jan;50(2):233-45. Unique Identifier : AIDSLINE MED/20084710; Petchey R; Farnsworth B; Williams J; Division of General Practice, University of Nottingham, Queen's; Medical Centre, UK. roland.petchey@nottingham.ac.uk; In England and Wales, departments of Genito-Urinary Medicine have led the clinical response to HIV infection and AIDS (HIV/AIDS). They provide an open-access self-referral service on a basis of strict confidentiality. People with HIV/AIDS have been found to be reluctant to involve their general practitioner (GP) in th
[Experience in the management of the HIV patient among the physicians of the Secretaria de Salud]: Salud Publica Mex. 1999 Nov-Dec;41(6):460-5. Unique Identifier : AIDSLINE MED/20099893; Magis-Rodriguez C; Esquivel-Pedraza L; Lopez-Martinez C; Consejo Nacional para la Prevencion y el Control del SIDA; (CONASIDA), Mexico, D.F. magis@cenids.ssa.gob.mx; OBJECTIVE: To determine the experience of the National Health Ministry physicians in the management of HIV-infected patients and in the use of antiretrovirals. MATERIAL AND METHOD: A descriptive, observational and transversal study was performed, with support from the National AIDS Council from March to May 1998. Self
[The UNAIDS challenges for the next millennium and the participation of Mexico (news)]: Salud Publica Mex. 1999 Nov-Dec;41(6):492-4. Unique Identifier : AIDSLINE MED/20099898; Uribe Zuniga P
CD4+ T cell response to factor VIII in hemophilia A, acquired hemophilia, and healthy subjects.: Thromb Haemost. 1999 Aug;82(2):509-15. Unique Identifier : AIDSLINE MED/20073677; Reding MT; Wu H; Krampf M; Okita DK; Diethelm-Okita BM; Key NS; Conti-Fine BM; Department of Biochemistry, Molecular Biology and Biophysics,; University of Minnesota, Minneapolis/St. Paul 55108, USA.; These studies have begun to clarify the complex cellular mechanisms involved in the immune response to factor VIII. Although vigorous sensitization of CD4+ cells occurs in healthy subjects, the absence of clini