Unusual presentation and course of HIV-1 progressive encephalopathy.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Unusual presentation and course of HIV-1 progressive encephalopathy.

Pediatr Neurol. 1999 Apr;20(4):301-4. Unique Identifier : AIDSLINE MED/99258832
Angelini L; Zibordi F; Triulzi F; Pinzani R; Plebani A; Department of Neuropediatrics, Istituto Nazionale Neurologico C.; Besta, Milan, Italy.

Abstract: The present report concerns a vertically human immunodeficiency virus type 1 (HIV-1)-infected 7-year-old child, in whom a neurodegenerative disease occurred after an acute neurologic disorder that was in all likelihood symptomatic of HIV-1 encephalitis. At the steady state the neurologic disease fulfilled the accepted criteria of HIV-related progressive encephalopathy of childhood and was characterized by involvement of multiple neural systems and subcortical dementia. The neurologic disease displayed, however, atypical presentation and course, and its acute focal onset led the authors to postulate an acute and direct involvement of the brain in HIV-1 infection. The correlation between the cliniconeuroradiologic data and levels of HIV-RNA in the cerebrospinal fluid and the response to different antiretroviral treatments are also discussed.

Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/TRANSMISSION AIDS Dementia Complex/COMPLICATIONS/*DIAGNOSIS/*THERAPY Brain/PATHOLOGY Case Report Cerebrospinal Fluid/VIROLOGY Child Disease Transmission, Vertical Drug Therapy, Combination Female Human HIV-1/*ISOLATION & PURIF Magnetic Resonance Imaging Meningitis/COMPLICATIONS Neurologic Examination Remission, Spontaneous Status Epilepticus/ETIOLOGY Support, Non-U.S. Gov't Tomography, X-Ray Computed
990930
A9991377

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .