Novel mechanism for the impairment of cell proliferation in HIV-1 infection. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Novel mechanism for the impairment of cell proliferation in HIV-1 infection.

Immunol Today. 1999 Jun;20(6):258-61. Unique Identifier : AIDSLINE MED/99284499
Bofill M; Borthwick NJ; Simmonds HA; Dept of Clinical Immunoloy, Royal Free Hospital, London, UK NW3; 2QG. bofill@rfhsm.ac.uk

Abstract: The synthesis of ribonucleotides is essential to cell proliferation. Defects in the relevant metabolic pathways have been demonstrated in stimulated T cells from AIDS patients and are associated with lymphocyte necrotic death. Here, Margarita Bofill and colleagues discuss the possibility that an impaired ribonucleotide metabolism might be common to all rapidly dividing cells and thus contribute to other recognized symptoms of HIV-1 infection.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Antigens, Differentiation/METABOLISM Cell Death/PHYSIOLOGY Cell Division Comparative Study Human HIV Infections/*IMMUNOLOGY *HIV-1/PHYSIOLOGY Lymphocyte Transformation Microscopy, Electron NAD+ Nucleosidase/METABOLISM Ribonucleotides/*METABOLISM T-Lymphocytes/*PATHOLOGY/PHYSIOLOGY/ULTRASTRUCTURE/VIROLOGYKWDjournalarticlereviewreview,tutorialantigens,differentiation/metabolismcelldeath/physiologycelldivisioncomparativestudyhumanhivinfections/KWDimmunologyKWDhiv-1/physiologylymphocytetransformationmicroscopy,electronnad+nucleosidase/metabolismribonucleotides/KWDmetabolismt-lymphocytes/KWDpathology/physiology/ultrastructure/virology
990930
A9991369

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