Interpatient genetic variability of HIV-1 group O. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Interpatient genetic variability of HIV-1 group O.

AIDS. 1999 Jan 14;13(1):41-8. Unique Identifier : AIDSLINE GENBANK/X96529
Janssens W; Heyndrickx L; Van der Auwera G; Nkengasong J; Beirnaert E; Vereecken K; Coppens S; Willems B; Fransen K; Peeters M; Ndumbe P; Delaporte E; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.

Abstract: OBJECTIVE: To analyse the genetic and phylogenetic characteristics of HIV-1 group O viruses. MATERIALS AND METHODS: The env gene, encoding the gp160 glycoprotein, and a partial p24-encoding gag gene fragment of a Cameroonian (CA9) and a Gabonese (VI686) HIV-1 group O virus, isolated from cultured peripheral blood mononuclear cells of symptomatic patients, were sequenced, aligned with other representatives of group O for which the same region has been documented, and genetically and phylogenetically analysed. RESULTS: Phylogenetic analysis of the env gene (gp160) revealed that CA9, VI686, ANT70, and four Ha strains formed a separate cluster, which was supported by 100% of all bootstrap trees. In addition, these seven isolates were part of the same clade in the p24 phylogeny. VAU and MVP5180 may represent two other subtypes. CONCLUSION: We have characterized two group O viruses, originating from Cameroon and Gabon, which show a close evolutionary relationship to ANT70 and four Ha strains based on the entire env gene, suggestive of a first group O subgroup, tentatively named the HIV-1 group O env ANT70 clade or subtype.
Keywords: JOURNAL ARTICLE Amino Acid Sequence Base Sequence DNA, Viral Human HIV Core Protein p24/*GENETICS HIV Envelope Protein gp160/*GENETICS HIV Infections/*VIROLOGY HIV-1/CLASSIFICATION/*GENETICS Molecular Sequence Data Phenotype Phylogeny Sequence Analysis Support, Non-U.S. Gov't *Variation (Genetics)KWDjournalarticleaminoacidsequencebasesequencedna,viralhumanhivcoreproteinp24/KWDgeneticshivenvelopeproteingp160/KWDgeneticshivinfections/KWDvirologyhiv-1/classification/KWDgeneticsmolecularsequencedataphenotypephylogenysequenceanalysissupport,non-uKWDsKWDgov'tKWDvariation(genetics)
990930
A9991343

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