Viral encoded cyclins. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Viral encoded cyclins.

Semin Cancer Biol. 1999 Jun;9(3):221-9. Unique Identifier : AIDSLINE MED/99276350
Cannell E; Mittnacht S; Department of Cell and Molecular Biology, Institute of Cancer; Research, 237, Fulham Road, London, SW3 6JB, UK.

Abstract: Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative agent of Kaposi's Sarcoma and lymphomas in humans. The significance of the virally encoded cyclin proteins in viral propagation is as yet unclear. However, the fact that deregulation of cellular cyclin expression is a known event in tumour development suggests that the virally encoded cyclins could be part of a mechanism utilised by these viruses to induce tumour formation. Copyright 1999 Academic Press.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Cyclin-Dependent Kinases/PHYSIOLOGY Cyclins/GENETICS/*PHYSIOLOGY Herpesvirus, Kaposi Sarcoma-Associated/*GENETICS Human Neoplasms/ETIOLOGYKWDjournalarticlereviewreview,tutorialanimalcyclin-dependentkinases/physiologycyclins/genetics/KWDphysiologyherpesvirus,kaposisarcoma-associated/KWDgeneticshumanneoplasms/etiology
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A9991282

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