Computerized and traditional stroop task dysfunction in HIV-1 infection.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Computerized and traditional stroop task dysfunction in HIV-1 infection.

Neuropsychology. 1999 Apr;13(2):306-16. Unique Identifier : AIDSLINE MED/99279820
Hinkin CH; Castellon SA; Hardy DJ; Granholm E; Siegle G; Department of Psychiatry and Biobehavioral Sciences, University; of California, Los Angeles (UCLA) School of Medicine and VA Los; Angeles Health Care System, 90024, USA. chinkin@ucla.edu

Abstract: Controlled processing, response inhibition, and set adoption were examined in 51 HIV-1 infected participants and 21 uninfected controls who were administered a vocal reaction time (RT) version of the Stroop task (Stroop-RT; J. R. Stroop, 1935) as well as the traditional 100 item paper-and-pencil version. Response set expectancies on the Stroop-RT were manipulated by presenting 50% of trials in homogenous blocks and randomly varying the stimulus type during the remaining trials. As hypothesized, HIV seropositive (HIV+) participants were significantly slower than HIV seronegative controls on both versions of the Stroop. Significant interference effects were apparent on the paper-and-pencil version of the Stroop, but were not as prominent on the Stroop-RT. The HIV+ participants did profit from the blocking manipulation on the Stroop-RT, suggesting that set adoption is retained in HIV infection. These data suggest that HIV infection may result in deficient response inhibition, possibly secondary to frontostriatal dysfunction and dopaminergic alterations.

Keywords: CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIAL Adult Analysis of Variance Cognition Disorders/DIAGNOSIS/*ETIOLOGY/*PHYSIOPATHOLOGY Diagnosis, Computer-Assisted Female Frontal Lobe/*PHYSIOPATHOLOGY Human HIV Seropositivity/*COMPLICATIONS *HIV-1 Inhibition (Psychology) Male Mental Processes Middle Age *Neuropsychological Tests Reaction Time Sensitivity and Specificity Set (Psychology) Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Visual Cortex/*PHYSIOPATHOLOGY
990930
A9990670

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