1999

Unusual presentation and course of HIV-1 progressive encephalopathy.: Pediatr Neurol. 1999 Apr;20(4):301-4. Unique Identifier : AIDSLINE MED/99258832; Angelini L; Zibordi F; Triulzi F; Pinzani R; Plebani A; Department of Neuropediatrics, Istituto Nazionale Neurologico C.; Besta, Milan, Italy.; The present report concerns a vertically human immunodeficiency virus type 1 (HIV-1)-infected 7-year-old child, in whom a neurodegenerative disease occurred after an acute neurologic disorder that was in all likelihood symptomatic of HIV-1 encephalitis. At the steady state the neurologic disease fulfilled the accepted
Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes.: J Autoimmun. 1999 Jun;12(4):251-8. Unique Identifier : AIDSLINE MED/99264266; Maron R; Melican NS; Weiner HL; Brigham and Women's Hospital and Harvard Medical School, Center; for Neurologic Diseases, 77 Avenue Louis Pasteur, Boston, MA; 02115, USA.; Non-obese diabetic (NOD) mice spontaneously develop diabetes. Ourselves and others have previously shown that oral and nasal administration of insulin or glutamic acid decarboxylase (GAD) suppresses development of diabetes in the NOD mouse and that this suppression appears secondary to the generation of regulatory T c
Enhanced human immunodeficiency virus infection in macrophages by high-molecular-weight dextran sulfate is associated with conformational changes of gp120 and expression of the CCR5 receptor.: Viral Immunol. 1999;12(1):23-33. Unique Identifier : AIDSLINE MED/99264034; Jagodzinski PP; Wierzbicki A; Wustner J; Kaneko Y; Kozbor D; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107, USA.; High-molecular-weight dextran sulfate (HMDS) inhibits infection of CD4+ lymphocytes by T-cell (T)-tropic human immunodeficiency virus (HIV) isolates, but augments replication of macrophage (M)-tropic isolates in primary human macrophages and phorbol myristate acetate (PMA)-differentiated THP-1 monocytic cells. To addr
Simian retrovirus receptor and neutralization mechanism by antibodies to the envelope glycoprotein.: Viral Immunol. 1999;12(1):47-56. Unique Identifier : AIDSLINE MED/99264037; Anderson DE; Torres JV; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis 95616, USA.; Type D simian retroviruses (SRV) cause an acquired immunodeficiency syndrome (AIDS) in monkeys. Results of infection with SRV range from complete recovery with absence of viremia to a viremic state, which produces AIDS-like symptoms and culminates in death. These varied outcomes render the interaction of the host and
Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: comparison with ELISA using synthetic peptides.: Viral Immunol. 1999;12(1):57-66. Unique Identifier : AIDSLINE MED/99264038; Ichiyama K; Ishikawa D; Tanaka Y; Kashiwa T; Koyanagi Y; Handa S; Yamashita A; Fukushi M; Yamamoto N; Taki T; Department of Microbiology, Tokyo Medical and Dental University; School of Medicine, Japan.; We generated a rat monoclonal antibody (mAb W#10) with the ability to neutralize human immunodeficiency virus type 1IIIB (HIV-1IIIB) infection. The epitope recognized by mAb W#10 was defined as R-I-Q-R-G-P-G by enzyme-linked immunosorbent assay (ELISA) with the use of synthetic peptides. The filamentous phage clones d
Characterization of neutralizing sites in the second variable and fourth variable region in gp125 and a conserved region in gp36 of human immunodeficiency virus type 2.: Unique Identifier : AIDSLINE MED/99264040; Skott P; Achour A; Norin M; Thorstensson R; Bjorling E; Several determinants of human immunodeficiency virus (HIV) have been suggested to harbor sites important for neutralization. The third variable region (V3) of the envelope glycoprotein (gp) is an important neutralizing determinant for both serotypes of HIV. The localization of additional neutralizing regions is an urg
Antigen-specific in vitro activation of T-lymphocyte subsets of cattle immunized with a modified live bovine herpesvirus 1 vaccine.: Viral Immunol. 1999;12(1):9-21. Unique Identifier : AIDSLINE MED/99264033; Quade MJ; Roth JA; Department of Veterinary Microbiology and Preventive Medicine,; College of Veterinary Medicine, Iowa State University, Ames; 50011, USA.; Bovine peripheral blood mononuclear cells from cattle immunized with a modified live virus bovine herpesvirus 1 (BHV1) vaccine and from BHV1-negative cattle were incubated in vitro with inactivated BHV1 for 6 days. Activation of T-lymphocyte subsets was measured by two-color flow cytometric analysis of T-cell phenotyp
Immune correlates of protection from HIV and AIDS - more answers but yet more questions.: Immunol Today. 1999 Jun;20(6):247-51. Unique Identifier : AIDSLINE MED/99284496; Heeney JL; Beverley P; McMichael A; Shearer G; Strominger J; Wahren B; Weber J; Gotch F; Dept of Virology, Biomedical Primate Research Centre, Lange; Kleiweg 157, 2288 GJ Rijswijk, The Netherlands. heeney@bprc.nl
Novel mechanism for the impairment of cell proliferation in HIV-1 infection.: Immunol Today. 1999 Jun;20(6):258-61. Unique Identifier : AIDSLINE MED/99284499; Bofill M; Borthwick NJ; Simmonds HA; Dept of Clinical Immunoloy, Royal Free Hospital, London, UK NW3; 2QG. bofill@rfhsm.ac.uk; The synthesis of ribonucleotides is essential to cell proliferation. Defects in the relevant metabolic pathways have been demonstrated in stimulated T cells from AIDS patients and are associated with lymphocyte necrotic death. Here, Margarita Bofill and colleagues discuss the possibility that an impaired ribonucleotid
T-cell clonality in immune responses.: Immunol Today. 1999 Jun;20(6):262-6. Unique Identifier : AIDSLINE MED/99284500; Maini MK; Casorati G; Dellabona P; Wack A; Beverley PC; Dept of Sexually Transmitted Diseases, Royal Free and University; College Medical School, Mortimer Market off Capper St, London, UK; WC1E 6AU. m.maini@ucl.ac.uk; Recent methodological advances allow the analysis of clonal composition within T-cell subsets. Here, Mala Maini and colleagues review the available data on clonality in acute immune responses and steady-state situations. They highlight and explore reasons for the striking differences in clonality between the CD4+ and
Protease inhibitor-containing regimens compared with nucleoside analogues alone in the suppression of persistent HIV-1 replication in lymphoid tissue.: AIDS. 1999 Jan 14;13(1):F1-8. Unique Identifier : AIDSLINE MED/99223945; Ruiz L; van Lunzen J; Arno A; Stellbrink HJ; Schneider C; Rull M; Castella E; Ojanguren I; Richman DD; Clotet B; Tenner-Racz K; Racz P; Retrovirology Laboratory, Fundacio irsiCaixa, Badalona, Spain.; OBJECTIVE: Lymphoid tissue provides a reservoir where HIV can persist. However, therapies incorporating a protease inhibitor can target this reservoir. This study was designed to investigate the relative long-term effects on lymph-node viral load and cellular architecture of regimens containing multiple nucleosides al
Combination therapy containing ritonavir plus saquinavir has superior short-term antiretroviral efficacy: a randomized trial.: AIDS. 1999 Jan 14;13(1):F9-16. Unique Identifier : AIDSLINE MED/99223946; Kirk O; Katzenstein TL; Gerstoft J; Mathiesen L; Nielsen H; Pedersen C; Lundgren JD; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.; OBJECTIVES: To compare the efficacy and safety of indinavir 800 mg three times a day, ritonavir 600 mg twice a day, and a combination of ritonavir 400 mg twice a day and saquinavir 40
Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis [editorial]: AIDS. 1999 Jan 14;13(1):1-22. Unique Identifier : AIDSLINE MED/99223947; Brack-Werner R
New therapy explains the fall in AIDS incidence with a substantial rise in number of persons on treatment expected.: AIDS. 1999 Jan 14;13(1):103-8. Unique Identifier : AIDSLINE MED/99223958; Aalen OO; Farewell VT; De Angelis D; Day NE; Gill ON; Section of Medical Statistics, University of Oslo, Norway.; BACKGROUND: A marked decline in the number of reported AIDS cases has been observed in the United Kingdom , as in many industrialized countries, in 1996 and 1997. In England and Wales, a large reduction in AIDS cases has been recorded among homosexual and bisexual men. OBJECTIVES: To in
Evaluation of HIV serial and parallel serologic testing algorithms in Abidjan, Cote d'Ivoire.: AIDS. 1999 Jan 14;13(1):109-17. Unique Identifier : AIDSLINE MED/99223959; Nkengasong JN; Maurice C; Koblavi S; Kalou M; Yavo D; Maran M; Bile C; N'guessan K; Kouadio J; Bony S; Wiktor SZ; Greenberg AE; Virology Laboratory, Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVE: To evaluate HIV serologic testing algorithms based on a combination of three enzyme linked immunosorbent assays (ELISA) for the confirmation of HIV infection in Abidjan, Cote d Ivoire , where HIV-2 and HIV-1 non-B subtypes are prevalent. METHODS: A total of 1069 huma
Is zidovudine therapy in pregnant HIV-infected women associated with gestational age and birthweight? The European Collaborative Study.: AIDS. 1999 Jan 14;13(1):119-24. Unique Identifier : AIDSLINE MED/99223960; Department of Epidemology and Public Health, Institute of Child; Health, London, UK.; OBJECTIVE: Prophylactic zidovudine during pregnancy and labour reduces maternal viral load and, with neonatal therapy, has been shown to reduce vertical transmission. However, zidovudine may have additional effects. Advanced HIV disease is associated with premature delivery, which in turn results in increased vertical
Post-partum sexual abstinence in West Africa: implications for AIDS-control and family planning programmes.: AIDS. 1999 Jan 14;13(1):125-31. Unique Identifier : AIDSLINE MED/99223961; Cleland JG; Ali MM; Capo-Chichi V; Centre for Population Studies, London School of Hygiene and; Tropical Medicine, UK.; OBJECTIVE: To assess whether the custom of prolonged post-partum sexual abstinence in Benin is associated with an increased incidence of extra-marital sexual contacts by husbands. DESIGN: Cross-sectional survey of adult men and women. METHODS: Data obtained from men on their extra-m
Serological testing algorithms for the diagnosis of HIV infection [editorial]: AIDS. 1999 Jan 14;13(1):133-4. Unique Identifier : AIDSLINE MED/99223962; Dax EM
Vaccination and HIV-1 replication during highly active antiretroviral therapy [letter]: AIDS. 1999 Jan 14;13(1):135-6. Unique Identifier : AIDSLINE MED/99223963; Kroon FP; Beersma MF; Kroes AC; Groeneveld PH; van Dissel JT
The decline of CD8+CD28+ peripheral lymphocytes is correlated with the evolution of AIDS in macaques infected with SIVmac251 [letter]: AIDS. 1999 Jan 14;13(1):136-7. Unique Identifier : AIDSLINE MED/99223964; Lebel-Binay S; Vaslin B; Gigout L; Parinello F; Le Grand R; Dormont D
Molecular typing of non-typhoid Salmonella strains isolated from HIV-infected patients with recurrent salmonellosis [letter]: AIDS. 1999 Jan 14;13(1):137-9. Unique Identifier : AIDSLINE MED/99223965; Rubino S; Spanu L; Mannazzu M; Schiaffino A; Mura MS; Cappuccinelli P; Aceti A
Cerebrospinal fluid S-100b concentrations in patients with HIV infection [letter]: AIDS. 1999 Jan 14;13(1):139-40. Unique Identifier : AIDSLINE MED/99223966; Green AJ; Giovannoni G; Miller RF; Harrison MJ; Thompson EJ
Recombinant interleukin-2 for treatment of HIV reduces hepatitis C viral load in coinfected patients [letter]: AIDS. 1999 Jan 14;13(1):140-1. Unique Identifier : AIDSLINE MED/99223967; Uberti-Foppa C; De Bona A; Morsica G; Guffanti M; Gianotti N; Boeri E; Lazzarin A
The prevalence of non-B subtype HIV-1 in a London HIV/AIDS outpatient clinic [letter]: Unique Identifier : AIDSLINE MED/99223968; Devereux H; Loveday C; Burke A
Incidence of HIV infection in homosexual men attending a sexually transmitted disease clinic in London measured by a novel unlinked anonymous method [letter]: AIDS. 1999 Jan 14;13(1):143-4. Unique Identifier : AIDSLINE MED/99223969; Miller E; Waight P; Mercey D; Parry J; Newham J; Nicoll A
Child feeding practices of HIV-positive mothers in Cape Town, South Africa [letter]: AIDS. 1999 Jan 14;13(1):144-6. Unique Identifier : AIDSLINE MED/99223970; Kuhn L; Mathews C; Fransman D; Dikweni L; Hussey G
HIV/AIDS, orphans, and access to school education in a community of Kampala, Uganda [letter]: AIDS. 1999 Jan 14;13(1):146-7. Unique Identifier : AIDSLINE MED/99223971; Muller O; Sen G; Nsubuga A
Withdrawal of Mycobacterium avium complex suppressive therapy in HIV-1-infected patients on highly active antiretroviral therapy [letter]: AIDS. 1999 Jan 14;13(1):147-8. Unique Identifier : AIDSLINE MED/99223972; Martinez E; Miro JM; Gonzalez J; Mallolas J; Gatell JM
Indinavir and thrombocytopenia [letter]: AIDS. 1999 Jan 14;13(1):148-9. Unique Identifier : AIDSLINE MED/99223973; Durand JM
Tuberculosis treatment practices in the era of protease inhibitors: a provider survey [letter]: AIDS. 1999 Jan 14;13(1):149-50. Unique Identifier : AIDSLINE MED/99223974; Sundaram V; Driver CR; Munsiff SS
Involvement of human interleukin-6 in systemic manifestations of human herpesvirus type 8-associated multicentric Castleman's disease [letter]: AIDS. 1999 Jan 14;13(1):150-2. Unique Identifier : AIDSLINE MED/99223975; Foussat A; Fior R; Girard T; Boue F; Wijdenes J; Galanaud P; Emilie D
Visceral leishmaniasis in HIV-infected patients with non-detectable HIV-1 viral load after highly active antiretroviral therapy [letter]: AIDS. 1999 Jan 14;13(1):152-3. Unique Identifier : AIDSLINE MED/99223976; Jimenez-Exposito MJ; Alonso-Villaverde C; Sarda P; Masana L
HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers.: AIDS. 1999 Jan 14;13(1):23-9. Unique Identifier : AIDSLINE MED/99223948; Kaul R; Trabattoni D; Bwayo JJ; Arienti D; Zagliani A; Mwangi FM; Kariuki C; Ngugi EN; MacDonald KS; Ball TB; Clerici M; Plummer FA; Department of Medical Microbiology and Community Health,; University of Nairobi, Kenya.; OBJECTIVES: Most HIV-1 transmission is sexual; therefore, immune responses in the genital mucosa may be important in mediating protection against HIV infection. This study examined HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan female sex workers. METHODS: HIV-1-specific immune responses were compare
Serum HIV-1 p24 antibody, HIV-1 RNA copy number and CD4 lymphocyte percentage are independently associated with risk of mortality in HIV-1-infected children. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group.: AIDS. 1999 Jan 14;13(1):31-9. Unique Identifier : AIDSLINE MED/99223949; Mofenson LM; Harris DR; Rich K; Meyer WA 3rd; Read JS; Moye J Jr; Nugent RP; Korelitz J; Bethel J; Pahwa S; Pediatric, Adolescent and Maternal AIDS Branch, Center for; Research for Mothers and Children, National Institute of Child; Health and Human Development, National Institutes of Health,; Rockville, MD 20852, USA.; OBJECTIVE: The role of HIV-1 antibody in modulating disease progression must be assessed in the context of other immune and viral load markers. We evaluated the association between HIV-1 p24 antibody, HIV-1 RNA, immune complex-dissociated (ICD) p24 antigen, CD4 cell percentage, and mortality in a cohort of 218 HIV-inf
Interpatient genetic variability of HIV-1 group O.: AIDS. 1999 Jan 14;13(1):41-8. Unique Identifier : AIDSLINE GENBANK/X96529; Janssens W; Heyndrickx L; Van der Auwera G; Nkengasong J; Beirnaert E; Vereecken K; Coppens S; Willems B; Fransen K; Peeters M; Ndumbe P; Delaporte E; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; OBJECTIVE: To analyse the genetic and phylogenetic characteristics of HIV-1 group O viruses. MATERIALS AND METHODS: The env gene, encoding the gp160 glycoprotein, and a partial p24-encoding gag gene fragment of a Cameroonian (CA9) and a Gabonese (VI686) HIV-1 group O virus, isolated from cultured peripheral blood mono
Granulocyte-macrophage colony-stimulating factor and fluconazole enhance anti-cryptococcal activity of monocytes from AIDS patients.: AIDS. 1999 Jan 14;13(1):49-55. Unique Identifier : AIDSLINE MED/99223951; Tascini C; Vecchiarelli A; Preziosi R; Francisci D; Bistoni F; Baldelli F; Department of Experimenta Medicine and Biochemical Sciences,; University of Perugia, Italy.; OBJECTIVE: To investigate the effect of human recombinant granulocyte-macrophage colony-stimulating factor (hrGM-CSF) and fluconazole on anti-cryptococcal activity of monocytes from AIDS patients and normal subjects. DESIGN: The effect of GM-CSF and fluconazole on fungistatic and fungicidal activity of monocytes was s
HIV-1 RNA response to antiretroviral treatment in 1280 participants in the Delta Trial: an extended virology study. Delta Coordinating Committee and Delta Virology Committee.: AIDS. 1999 Jan 14;13(1):57-65. Unique Identifier : AIDSLINE MED/99223952; Medical Research Council Clinical Trials Unit, University College; London Medical School, UK.; OBJECTIVE: To assess changes in HIV RNA and their relationship to disease progression. DESIGN AND SETTING: Delta was a randomized double-blind trial comparing zidovudine (ZDV) monotherapy with ZDV plus didanosine (ddI) or ZDV plus zalcitabine ( ddC ). P
In vivo HIV-1 replicative capacity in early and advanced infection.: AIDS. 1999 Jan 14;13(1):67-73. Unique Identifier : AIDSLINE MED/99223953; Phillips AN; McLean AR; Loveday C; Tyrer M; Bofill M; Devereux H; Madge S; Dykoff A; Drinkwater A; Burke A; Huckett L; Janossy G; Johnson MA; Royal Free Centre for HIV Medicine, Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, London, UK.; OBJECTIVE: Previous studies on patients treated with potent antiretroviral therapy have shown that viral clearance rates do not tend to change between early and advanced HIV-1 infection. Our objective was to investigate whether the other major aspect of virus dynamics, viral replicative capacity, does change. In vitro
Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs.: AIDS. 1999 Jan 14;13(1):75-80. Unique Identifier : AIDSLINE MED/99223954; de Jong JJ; Goudsmit J; Lukashov VV; Hillebrand ME; Baan E; Huismans R; Danner SA; ten Veen JH; de Wolf F; Jurriaans S; Department of Human Retrovirology, Academic Medical Centre,; University of Amsterdam, The Netherlands.; OBJECTIVE: To identify genotypic drug resistance patterns of HIV-1 in patients who were extensively pretreated with anti-HIV drugs and not responding to their current antiretroviral combination therapy . METHODS: Drug susceptibility of the viruses was tested by a phenot
Combination antiretroviral therapy including ritonavir in children infected with human immunodeficiency.: AIDS. 1999 Jan 14;13(1):81-7. Unique Identifier : AIDSLINE MED/99223955; Thuret I; Michel G; Chambost H; Tamalet C; Giraud P; Brunet C; Perrimond H; Service d'Hematologie Pediatrique, CHU Timone, Marseille,; France.; OBJECTIVE: To assess the efficacy of combination therapy that includes ritonavir in HIV-1 infected children. DESIGN: A monocentric retrospective study. PATIENTS AND METHODS: Twenty-two children with a
Persistently negative HIV-1 antibody enzyme immunoassay screening results for patients with HIV-1 infection and AIDS: serologic, clinical, and virologic results. Seronegative AIDS Clinical Study Group.: AIDS. 1999 Jan 14;13(1):89-96. Unique Identifier : AIDSLINE MED/99223956; Sullivan PS; Schable C; Koch W; Do AN; Spira T; Lansky A; Ellenberger D; Lal RB; Hyer C; Davis R; Marx M; Paul S; Kent J; Armor R; McFarland J; Lafontaine J; Mottice S; Cassol SA; Michael N; Surveillance Branch, National Center for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; GA 30333, USA.; OBJECTIVE: To describe persons with HIV infection and AIDS but with persistently negative HIV antibody enzyme immunoassay (EIA) results. DESIGN: Surveillance for persons meeting a case definition for HIV-1-seronegative AIDS. SETTING: United States and C
Protease inhibitors as initial therapy for individuals with an intermediate risk of HIV disease progression: is more necessarily better?: AIDS. 1999 Jan 14;13(1):97-102. Unique Identifier : AIDSLINE MED/99223957; Schechter M; Struchiner CJ; Harrison LH; Infectious Diseases Service, Hospital Universitario Clementino; Fraga Filho, Rio de Janeiro, Brazil.; OBJECTIVE: To compare three possible therapeutic strategies for the treatment of patients with an intermediate risk of HIV disease progression. DESIGN: Mathematical modeling based on assumptions derived from published data. METHODS: A parametric survival model was fitted to empirical data to describe the survival traj
Quantification of RNA in HIV type 1 subtypes D and G by NucliSens and Amplicor assays in Abidjan, Ivory Coast.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):495-8. Unique Identifier : AIDSLINE MED/99236715; Nkengasong JN; Bile C; Kalou M; Maurice C; Boateng E; Sassan-Morokro M; Rayfield M; Coulibaly D; Greenberg AE; Wiktor SZ; Projet RETRO-CI, CHU Treichville, Abidjan, Ivory Coast.; jcn5@cdc.gov; We have compared the performance of the NucliSens and the standard and modified HIV Monitor assays to quantify HIV-1 RNA plasma viral load in 12 tuberculosis patients infected with HIV-1 env subtype D (n = 3) and env subtype G (n = 9) in Ivory Coast . RNA was quantified in all
Modeling the long-term outcomes and costs of HIV antiretroviral therapy using HIV RNA levels: application to a clinical trial.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):499-508. Unique Identifier : AIDSLINE MED/99236716; Cook J; Dasbach E; Coplan P; Markson L; Yin D; Meibohm A; Nguyen BY; Chodakewitz J; Mellors J; Merck & Co., Inc., Whitehouse Station, New Jersey 08889, USA.; john_cook@merck.com; A model was developed to gain insight into the potential clinical and economic impact of antiretroviral therapy for HIV-infected patients. Observed HIV RNA levels and CD4 cell counts are used in the model to estimate the probability that an individual progresses from asymptomatic infection to the first AIDS-defining i
B7 cosignal potentiates apoptosis of uninfected CD4+ T lymphocytic cell lines primed by HIV envelope proteins.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):509-21. Unique Identifier : AIDSLINE MED/99236717; Coito C; Bomsel M; Unite 332 de l'INSERM, Institut Cochin de Genetique; Moleculaire, Paris, France.; In lymphoid organs, follicular dendritic cells (FDCs), monocytes, and macrophages are targets for HIV infection and reservoirs for infectious virus. Strikingly, the apoptotic cells in these sites are essentially uninfected CD4+ T lymphocytes, but lie in close proximity to infected cells or FDCs carrying trapped HIV vi
Enhanced HIV type 1 neutralization by human anti-glycoprotein 120 monoclonal antibodies in the presence of monoclonal antibodies to lymphocyte function-associated molecule 1.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):523-31. Unique Identifier : AIDSLINE MED/99236718; Hioe CE; Hildreth JE; Zolla-Pazner S; Department of Pathology, New York University Medical Center and; Manhattan VA Medical Center, New York 10010, USA.; Cellular adhesion receptor LFA-1 and its ICAM ligands are known to play a role in HIV infection. The presence of these molecules on virions and target cells promotes virus infectivity and has previously been shown to hinder virus neutralization by anti-HIV antibodies. To delineate the effect of these molecules on neut
Neutralization of HIV type 1 by alloimmune sera derived from polytransfused patients.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):533-43. Unique Identifier : AIDSLINE MED/99236719; Spruth M; Stoiber H; Kacani L; Schonitzer D; Dierich MP; Institut fur Hygiene, Leopold-Franzens-Universitat Innsbruck; and Ludwig-Boltzmann Institut fur AIDS-Forschung, Innsbruck,; Austria.; Antibodies (Abs) against HLA and other cell surface molecules, which HIV-1 acquires during the budding process at the host cell surface, neutralize HIV-1 in vitro. Macaques were protected against infection by SIV grown in human cells after xenoimmunization with human MHC molecules. Besides the immune responses arising
Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):545-50. Unique Identifier : AIDSLINE MED/99236720; Kim JM; Hong Y; Kim S; Cho MH; Yoshida M; Jeang KT; Burns W; Kim S; Institute for Molecular Biology and Genetics, Seoul National; University, South Korea.; Human T cell leukemia virus type I infection is associated with a low incidence of morbidity in the form of adult T cell leukemia and neurologic disease, suggesting that there are other factors determining the pathogenic outcome of infection. We found that HCMV could infect various human cell lines known to be suscept
The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type 1-infected patients.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):551-9. Unique Identifier : AIDSLINE MED/99236721; Adams GB; Pym AS; Poznansky MC; McClure MO; Weber JN; Department of Genito-Urinary Medicine and Communicable Diseases,; Jefferiss Research Trust Laboratories, Imperial College School of; Medicine, London, England.; This study investigated the effects of a combination antiretroviral drug regimen ( indinavir and two nucleoside analogs or ritonavir and saquinavir) on the levels of CD34+ colony-formi
Expression and characterization of HIV type 1 envelope protein: Unique Identifier : AIDSLINE MED/99236722
Simple and choice reaction time performance in SIV-infected rhesus macaques.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):571-83. Unique Identifier : AIDSLINE MED/99236723; Marcario JK; Raymond LA; McKiernan BJ; Foresman LL; Joag SV; Raghavan R; Narayan O; Hershberger S; Cheney PD; Department of Molecular and Integrative Physiology, Smith Mental; Retardation and Human Development Research Center, University of; Kansas, Lawrence 66045, USA.; It is well established that HIV infection can lead to motor/cognitive disorders in humans. A number of studies have shown that simian immunodeficiency virus (SIV) infection in rhesus macaques parallels many aspects of HIV disease in humans. The purpose of this study was to define further the SIV-infected rhesus macaqu
Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):585-9. Unique Identifier : AIDSLINE GENBANK/AF084936; Oelrichs RB; Vandamme AM; Van Laethem K; Debyser Z; McCutchan FE; Deacon NJ; AIDS Molecular Biology Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield, Australia.
Retroviral RNA related to ERV9/MSRV in a human serum: a new sequence variant.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):591-3. Unique Identifier : AIDSLINE GENBANK/AF109183; Olsson P; Ryberg B; Awad R; Ammoun S; Yin H; Hjalmarsson S; Blomberg J; Department of Medical Sciences, University Hospital, Uppsala,; Sweden.
Cloning and nucleotide sequence of retroposons specific to hominoid primates derived from an endogenous retrovirus (HERV-K).: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):595-601. Unique Identifier : AIDSLINE GENBANK/AB016782; Kim HS; Takenaka O; Crow TJ; POWIC, Department of Psychiatry, Warneford Hospital, University; of Oxford, United Kingdom.
Predominance of human immunodeficiency virus type 2 subtype B in Abidjan, Ivory Coast.: AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):603-8. Unique Identifier : AIDSLINE MED/99236727; Pieniazek D; Ellenberger D; Janini LM; Ramos AC; Nkengasong J; Sassan-Morokro M; Hu DJ; Coulibally IM; Ekpini E; Bandea C; Tanuri A; Greenberg AE; Wiktor SZ; Rayfield MA; Division of AIDS, STD, and TB Laboratory Research, National; Centers for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA. dxp1@cdc.gov; We analyzed the genetic variability and phylogenetic relationships among 28 HIV-2 strains collected from patients enrolled in an HIV epidemiologic study in Abidjan, Ivory Coast , during 1995-1996. Although both subtype A (n = 8; 29%) and subtype B (n = 20; 71%) were present in d
The Women and Infants Demonstration Project: an integrated approach to AIDS prevention and research.: AIDS Educ Prev. 1999 Apr;11(2):107-21. Unique Identifier : AIDSLINE MED/99231110; Terry MA; Liebman J; Person B; Bond L; Dillard-Smith C; Tunstall C; Graduate School of Public Health, University of Pittsburgh, PA; 15261, USA.; The Women and Infants Demonstration Project is a multisite, behavioral intervention research effort funded by the Centers for Disease Control. The project is evaluating a theory-based, integrated intervention model to increase the use of condoms for prevention of both sexually transmitted diseases (STDs) and unintended
Do actions speak louder than words? Perceived peer influences on needle sharing and cleaning in a sample of injection drug users.: Unique Identifier : AIDSLINE MED/99231111; Hawkins WE; Latkin C; Mandel W; Oziemkowska M; Florida Atlantic University, Department of Social Work, Boca; Raton 33487, USA.; Past research (Dielman, Butchart, Shope, & Miller, 1990; Kandel, 1980) has found peer influence, perceived peer norms and perceived peer behavior as the strongest predictors of drug use in adolescent and young adult populations. The purpose of this study was to investigate whether verbal persuasion (peer norms) and
HIV risk behaviors, intentions, and perceptions among Namibian youth as assessed by a theory-based questionnaire.: AIDS Educ Prev. 1999 Apr;11(2):132-49. Unique Identifier : AIDSLINE MED/99231112; Stanton BF; Fitzgerald AM; Li X; Shipena H; Ricardo IB; Galbraith JS; Terreri N; Strijdom J; Hangula-Ndlovu V; Kahihuata J; Department of Pediatrics, University of Maryland, Baltimore; 21201, USA. bstanton@umabnet.ab.umd.edu; Considerable progress has been made in the United States and Europe regarding HIV risk prevention efforts targeting adolescents. However, in Africa less progress has been made to date. This article address three questions: Can risk assessment questionnaires developed in Western countrin
Persuasive communication about AIDS prevention: need for cognition determines the impact of message format.: AIDS Educ Prev. 1999 Apr;11(2):150-62. Unique Identifier : AIDSLINE MED/99231113; Bakker AB; Department of Social and Organizational Psychology, Utrecht; University, The Netherlands. A.Bakker@fss.un.nl; Adolescents were classified as being high or low in need for cognition (NFC) (Cacioppo & Petty, 1982) and expressed their knowledge about AIDS, attitudes toward condom use, and perceived supportive norms after being exposed to a cartoon or a written message about safe sex. Both messages have a positive impact on kn
Knowledge, attitudes, beliefs, and practices about HIV/AIDS in Kuwait.: AIDS Educ Prev. 1999 Apr;11(2):163-73. Unique Identifier : AIDSLINE MED/99231114; al-Owaish R; Moussa MA; Anwar S; al-Shoumer H; Sharma P; Department of Community Health, Al Shamieh, Kuwait.; This survey is aimed at assessing knowledge, attitudes, beliefs and practices in Kuwait regarding AIDS/HIV. Structured face-to-face interviews were conducted during the year 1995 on a sample of 2,219 subjects, aged 18 to 60, health 7
Prepubertal boys' sexual behavior and behavior problems.: AIDS Educ Prev. 1999 Apr;11(2):174-86. Unique Identifier : AIDSLINE MED/99231115; Meyer-Bahlburg HF; Dolezal CL; Wasserman GA; Jaramillo BM; New York State Psychiatric Institute, USA.; The increasingly early initiation of penetrative sexual practices and the implication for prevention of HIV and sexually transmitted diseases requires the study of childhood sexual behavior and its determinants. In adolescence, early sexual initiation is associated with other problem behaviors (Jessor & Jessor, 197
Heterosexual men's attitudes toward the female condom.: AIDS Educ Prev. 1999 Apr;11(2):93-106. Unique Identifier : AIDSLINE MED/99231109; Seal DW; Ehrhardt AA; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53202, USA. dseal@mcw.edu; This article addresses heterosexual men s familiarity with the female condom and their attitudes toward this barrier method. Qualitative interviews were conducted with 71 ethnically diverse and heterosexually active men who were recruited in sexually transmitted disease (STD) clinics or through word of mouth in commun
AIDS drugs effective against most common HIV strain [news]: Oncology (Huntingt). 1999 Mar;13(3):392. Unique Identifier : AIDSLINE MED/99220358
Acquired immunodeficiency syndrome-related primary cerebral lymphoma.: Clin Oncol (R Coll Radiol). 1999;11(1):6-14. Unique Identifier : AIDSLINE MED/99210485; Khoo VS; Liew KH; Royal Marsden NHS Trust, Sutton, UK.
Elective surgery and the patient with human immunodeficiency virus [editorial]: Ophthal Plast Reconstr Surg. 1999 May;15(3):151-2. Unique Identifier : AIDSLINE MED/99281962; Schipper AM
Regulatory T cells in experimental allergic encephalomyelitis. I. Frequency and specificity analysis in normal and immune rats of a T cell subset that inhibits disease.: Int Immunol. 1999 Mar;11(3):307-15. Unique Identifier : AIDSLINE MED/99236831; Sun D; Whitaker JN; Wilson DB; Department of Neurology and the Center for Neuroimmunology,; University of Alabama at Birmingham, 35294, USA.; We have shown previously that administration of myelin basic protein (MBP)-reactive T cells to naive Lewis rats induces not only autoimmune encephalomyelitis (EAE) but also a near total resistance to subsequent disease. By isolating the effector cells that are responsible for the resistance, we demonstrated that disea
IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes.: Int Immunol. 1999 Mar;11(3):325-32. Unique Identifier : AIDSLINE MED/99236833; Brombacher F; Dorfmuller A; Magram J; Dai WJ; Kohler G; Wunderlin A; Palmer-Lehmann K; Gately MK; Alber G; Max-Planck-Institute for Immunobiology, Freiburg, Germany.; We have studied IL-12p35-deficient (IL-12p35(-/-)) mice to evaluate the role of IL-12 in resistance against Listeria monocytogenes. In the absence of bioactive IL-12p75, mutant mice acquired higher bacterial organ burden than wild-type mice and died during the first week following infection with normally sublethal dos
c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.: Int Immunol. 1999 Mar;11(3):361-71. Unique Identifier : AIDSLINE MED/99236837; Liou HC; Jin Z; Tumang J; Andjelic S; Smith KA; Liou ML; Cornell University Medical College, Department of Medicine, New; York, NY 10021, USA.; The TCR signals are essential for T cell activation and proliferation, primarily through the induction of cytokine and cytokine receptors. Several transcription factor families, including NF-kappaB/Rel, have been implicated in the regulation of cytokine gene expression in T cells in response to antigen, cytokine and m
Differential CD4/CD8 subset-specific expression of highly homologous rat Tcrb-V8 family members suggests a role of CDR2 and/or CDR4 (HV4) in MHC class-specific thymic selection.: Int Immunol. 1999 Mar;11(3):435-44. Unique Identifier : AIDSLINE MED/99236844; Herrmann T; Hofmann K; Nagel NE; Asmuss A; Hunig T; Wonigeit K; Institut fur Virologie und Immunobiologie,; Julius-Maximillians-Universitat Wurzburg, Germany.; herrmann-t@vim.uni-wuerzburg.de; Different rat Tcrb haplotypes express either TCR beta variable segment (Tcrb-V) 8.2l or 8.4a. Both V segments bind the mAb R78 but differ by one conservative substitution (L14V) and clusters of two and four substitutions in the complementarity-determining region (CDR) 2 and CDR4 [hypervariable loop 4 (HV4)]. Independe
AIDS related eye disease in Burundi, Africa.: Br J Ophthalmol. 1999 Mar;83(3):339-42. Unique Identifier : AIDSLINE MED/99293378; Cochereau I; Mlika-Cabanne N; Godinaud P; Niyongabo T; Poste B; Ngayiragije A; Dazza MC; Aubry P; Larouze B; IMEA/INSERM U13, Hopital Bichat, Paris, France.; AIMS: To determine the prevalence of ocular manifestations in AIDS patients hospitalised in Bujumbura, Burundi , according to their CD4+ lymphocyte count, serological status for CMV and VZV, and general health status. METHODS
Biodiversity and bioseparation of HIV-1 envelope glycoproteins.: Crit Rev Oncog. 1999;10(1-2):1-16. Unique Identifier : AIDSLINE MED/99257141; Shao Y; Lu Y; National Center for AIDS Prevention and Control, Beijing, P.R.; China.; Since 1984, studies from almost every branch of modern biology have filled in many gaps in our knowledge of human immunodeficiency virus type 1 (HIV-1). This review focuses on studies of biodiversity and bioseparation of HIV-1 envelope glycoproteins from the vaccine development point of view. It presents an updated pi
[Kikuchi disease in an acquired immunodeficiency syndrome patient (letter)]: Enferm Infecc Microbiol Clin. 1999 Apr;17(4):193-4. Unique Identifier : AIDSLINE MED/99293851; Abad A; Baraia-Etxaburu J; Munoz J; Santamaria JM
[Myocarditis by Toxoplasma in a patient with human immunodeficiency virus infection (letter)]: Enferm Infecc Microbiol Clin. 1999 Apr;17(4):200-1. Unique Identifier : AIDSLINE MED/99293857; Segura JC; Hardisson D; Martinez-Alfaro E; Solera J
Issues in the treatment of active tuberculosis in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1999 Jan;28(1):130-5. Unique Identifier : AIDSLINE MED/99152409; Schluger NW; Division of Pulmonary, Allergy, and Critical Care Medicine,; Columbia University College of Physicians and Surgeons, New York,; New York 10032, USA. ns311@columbia.edu; Most HIV-infected patients with tuberculosis can be treated satisfactorily with standard regimens with expectations of good results. Treatment of tuberculosis in these patients has been complicated by the introduction of HAART, which relies on drugs that interfere with the most potent class of antituberculous medicati
Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group.: Clin Infect Dis. 1999 Jan;28(1):136-8. Unique Identifier : AIDSLINE MED/99152410; Dube MP; Torriani FJ; See D; Havlir DV; Kemper CA; Leedom JM; Tilles JG; McCutchan JA; Sattler FR; University of Southern California School of Medicine, Los; Angeles. mdube@hsc.usc.edu; During a randomized study of clarithromycin plus clofazimine with or without ethambutol in patients with AIDS and Mycobacterium avium complex (MAC) bacteremia, eight participants received additional antimycobacterial drugs following the detection of a clarithromycin-resistant isolate (MIC, > 8 micrograms/mL). A macrol
Clinical experience and choice of drug therapy for human immunodeficiency virus disease [see comments]: Clin Infect Dis. 1999 Jan;28(1):14-22. Unique Identifier : AIDSLINE MED/99152389; Brosgart CL; Mitchell TF; Coleman RL; Dyner T; Stephenson KE; Abrams DI; Community Consortium, University of California San Francisco AIDS; Program, San Francisco General Hospital, USA.; To determine if providers experienced in the management of human immunodeficiency virus (HIV) disease preferred different treatment regimens than providers with less experience, we analyzed data from a national survey of primary care providers preferred regimens for the management of 30 HIV-related medical conditions
Ehrlichia chaffeensis--associated cardiomyopathy in a patient with AIDS.: Clin Infect Dis. 1999 Jan;28(1):140. Unique Identifier : AIDSLINE MED/99152411; Whitt SP; Everett ED; Roland W; Dolan S; Department of Internal Medicine, University of Missouri, Columbia; 65212, USA. medspw@showme.missouri.edu
Identification of Shigella boydii in colonic malacoplakia by universal bacterial 16S ribosomal DNA-based amplification in a human immunodeficiency virus-infected patient.: Clin Infect Dis. 1999 Jan;28(1):142-3. Unique Identifier : AIDSLINE MED/99152413; Raguin G; Nemeth J; Wassef M; Aerts J; Salmeron M; Desplaces N; Belec L; Department of Internal Medicine, Hopital de la Croix-Saint-Simon,; Paris, France. g.raguin@croix-saint-simon.org
Disseminated Nocardia pseudobrasiliensis infection in a patient with AIDS in Brazil.: Clin Infect Dis. 1999 Jan;28(1):144-5. Unique Identifier : AIDSLINE MED/99152415; Brown BA; Lopes JO; Wilson RW; Costa JM; de Vargas AC; Alves SH; Klock C; Onyi GO; Wallace RJ Jr; University of Texas Health Center, Department of Microbiology,; Tyler 75708, USA. babrown@uthct.edu
Strongyloidiasis and infection due to human immunodeficiency virus: 25 cases at a Brazilian teaching hospital, including seven cases of hyperinfection syndrome.: Clin Infect Dis. 1999 Jan;28(1):154-5. Unique Identifier : AIDSLINE MED/99152423; Ferreira MS; Nishioka S de A; Borges AS; Costa-Cruz JM; Rossin IR; Rocha A; Silvestre MT; Nunes-Araujo FR; Centro de Ciencias Biomedicas, Universidade Federal de; Uberlandia, Brazil. mferreira@hc.ufu.br
Ritonavir, triglycerides, and pancreatitis.: Clin Infect Dis. 1999 Jan;28(1):161-2. Unique Identifier : AIDSLINE MED/99152429; Perry RC; Cushing HE; Deeg MA; Prince MJ; Department of Medicine, Indiana University School of Medicine,; Indianapolis, USA.
Time for a new paradigm--optimal management of patients with human immunodeficiency virus infection and AIDS [editorial; comment]: Clin Infect Dis. 1999 Jan;28(1):23-5. Unique Identifier : AIDSLINE MED/99152390; Robbins GK
Early mycological treatment failure in AIDS-associated cryptococcal meningitis.: Clin Infect Dis. 1999 Jan;28(1):82-92. Unique Identifier : AIDSLINE MED/99152402; Robinson PA; Bauer M; Leal MA; Evans SG; Holtom PD; Diamond DA; Leedom JM; Larsen RA; Department of Medicine, University of Southern California School; of Medicine, USA.; Cryptococcal meningitis causes significant morbidity and mortality in persons with AIDS. Of 236 AIDS patients treated with amphotericin B plus flucytosine, 29 (12%) died within 2 weeks and 62 (26%) died before 10 weeks. Just 129 (55%) of 236 patients were alive with
[Caring for AIDS patients at home--requirements for development of the concept]: Pflege. 1997 Dec;10(6):327-34. Unique Identifier : AIDSLINE MED/98117895; Moers M; Fachhochschule Osnabruck, Fachbereich Wirtschaft.; Several studies concerning the care of patients with AIDS were carried out at the Wissenschaftszentrum Berlin for social research. Amongst other areas the out-patient nursing care for patients with AIDS in Germany was examined. The following article presents a case study which sho
Combinations of four virostatics applied in rotational sequences induce an exponential VL regression curve, the first part of which is rapidly decreasing to a PCR-undetectable level, while the last part is insensitive to the model. Indications for virostatic and immunotherapeutic reinforcements? [editorial]: Biomed Pharmacother. 1999 Mar;53(2):57-62. Unique Identifier : AIDSLINE MED/99269753; Mathe G; Between 1992 and 1995, we have had five virostatics available: zidovudine ( AZT ), didanosine (ddI), zalcitabine ( ddC ) (as retrotranscriptase nucleosidic antagonists, RTNA), acriflavine
Antiretroviral therapy: 'the state of the art'.: Biomed Pharmacother. 1999 Mar;53(2):63-72. Unique Identifier : AIDSLINE MED/99269754; Montaner JS; Montessori V; Harrigan R; O'Shaughnessy M; Hogg R; BC Center for Excellence on HIV/AIDS St Paul's Hospital,; University of British Columbia, Vancouver, Canada.; The field of antiretroviral therapy is evolving at a very rapid pace. At this time, the initiation and optimization of antiretroviral therapy is based on serial plasma viral load determinations which aim to suppress viral replication to as low as possible for as long as possible, thus preventing disease progression. C
Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1.: Biomed Pharmacother. 1999 Mar;53(2):73-86. Unique Identifier : AIDSLINE MED/99269755; Shafer RW; Vuitton DA; Division of Infectious Diseases and Geographic Medicine, Stanford; University, CA 94305, USA.; Highly active antiretroviral therapy (HAART) refers to a broad category of treatment regimens usually comprised of three or more antiretroviral drugs that, in previously untreated HIV-1-infected patients, are expected to reduce plasma virus levels below the limits of detection. Most HAART regimens include drugs from a
IFN alpha kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS.: Unique Identifier : AIDSLINE MED/99269756; Bizzini B; Volpato I; Lachgar A; Cohen P
Anti-IFN alpha immunization raises the IFN alpha-neutralizing capacity of serum--an adjuvant to antiretroviral tritherapy.: Biomed Pharmacother. 1999 Mar;53(2):90-2. Unique Identifier : AIDSLINE MED/99269757; Zagury D; Lecoq H; Gervi I; Le Buanec H; Zagury JF; Bizzini B; Burny A; Hermans P; Perja M; Santagostino E; Gringeri A; Laboratoire de Physiologie Cellulaire, P. et M. Curie University,; Paris, France.; HAART (highly active antiretroviral therapy) suppresses but does not eradicate HIV-1 infection. However, since the antiretroviral agents used in HAART may also be toxic in the long-term, immunotherapies which correct HIV-1 immunosuppression or the cytokine dysregulation associated with it may be beneficial. In this re
HIV disease treatment in the era of HAART.: Biomed Pharmacother. 1999 Mar;53(2):93-105. Unique Identifier : AIDSLINE MED/99269758; Bonfanti P; Capetti A; Rizzardini G; 1st Department of Infectious Diseases and Allergy, Luigi Sacco; Hospital, Milan, Italy.; In the last three years basic science and clinical research have radically changed the therapeutical approach to HIV disease. Recent guidelines suggest that treatments to HIV disease should be early and aggressive, with the use of new potent antiretroviral drugs. This approach has been defined as HAART (highly active
The role of HHV-8 in Kaposi's sarcoma.: Semin Cancer Biol. 1999 Jun;9(3):151-64. Unique Identifier : AIDSLINE MED/99276344; Neipel F; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Erlangen, D-91054, Germany.; The epidemiology of Kaposi s sarcoma (KS) amongst North American and Northern European patients with AIDS suggests that an infectious agent other than HIV is involved in its pathogenesis. Several lines of evidence indicate that human herpesvirus 8 (HHV-8), also termed Kaposi s sarcoma associated herpesvirus, is the so
The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases.: Semin Cancer Biol. 1999 Jun;9(3):165-74. Unique Identifier : AIDSLINE MED/99276345; Cesarman E; Knowles DM; Department of Pathology, Weill Medical College of Cornell; University, 1300 York Avenue, New York.; The Kaposi s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), has been found to be present in a limited subset of lymphoproliferative disorders. Among these are the primary effusion lymphomas, formerly designated body cavity-based lymphomas, a rare type of malignant lymphoma which posses
Seroepidemiology of Kaposi's sarcoma-associated herpesvirus (KSHV).: Semin Cancer Biol. 1999 Jun;9(3):175-85. Unique Identifier : AIDSLINE MED/99276346; Chatlynne LG; Ablashi DV; Advanced Biotechnologies Inc, Columbia, Maryland 21046, USA.; Since the Kaposi s sarcoma-associated herpesvirus (KSHV also referred to as HHV-8, human herpesvirus-8) was discovered it has been shown that the virus is associated with all cases of Kaposi s sarcoma (KS) classical, endemic, or AIDS associated. In the numerous countries where the seroprevalence of this virus has been
KSHV strains: the origins and global spread of the virus.: Semin Cancer Biol. 1999 Jun;9(3):187-99. Unique Identifier : AIDSLINE MED/99276347; Hayward GS; Molecular Virology Laboratories, Departments of Oncology, and; Pharmacology and Molecular Sciences, The Johns Hopkins School of; Medicine, 725 N. Wolfe Street, WBSB 317, Baltimore, MD 21205,; USA.; Nucleotide sequence analysis at five distinct loci across the 140, 000 bp genomes of more than 60 KSHV samples from KS and PEL tumors from North America, Africa, the Middle East, Asia and the Pacific revealed that they cluster into four major subtypes (A, B, C and D) that have close associations with the geographic an
The descent of human herpesvirus 8.: Semin Cancer Biol. 1999 Jun;9(3):201-9. Unique Identifier : AIDSLINE MED/99276348; McGeoch DJ; Davison AJ; MRC Virology Unit, Church Street, Glasgow, G11 5JR, UK.; Analysis of conserved herpesvirus genes shows that human herpesvirus 8 (HHV8) belongs to a clade of primate herpesviruses within the gamma2 sublineage. Overall, this clade has developed by cospeciation with host species. Seventeen genes of HHV8 and its nearest relatives lack simple homologues in other herpesviruses, a
Viral encoded cyclins.: Semin Cancer Biol. 1999 Jun;9(3):221-9. Unique Identifier : AIDSLINE MED/99276350; Cannell E; Mittnacht S; Department of Cell and Molecular Biology, Institute of Cancer; Research, 237, Fulham Road, London, SW3 6JB, UK.; Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative agent of Kaposi s Sarcoma a
Inflammatory reactivation and angiogenicity of Kaposi's sarcoma-associated herpesvirus/HHV8: a missing link in the pathogenesis of acquired immunodeficiency syndrome-associated Kaposi's sarcoma [comment]: Blood. 1999 Jun 15;93(12):4031-3. Unique Identifier : AIDSLINE MED/99290756; Mesri EA; Laboratory of Viral Oncogenesis, Division of Hematology-Oncology,; Department of Medicine, Center for Lymphoma and Myeloma, Weill; Medical College of Cornell University, New York, NY, USA.; eamesri@mail.med.cornell.edu
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 [see comments]: Blood. 1999 Jun 15;93(12):4034-43. Unique Identifier : AIDSLINE MED/99290757; Aoki Y; Jaffe ES; Chang Y; Jones K; Teruya-Feldstein J; Moore PS; Tosato G; Division of Hematologic Products, Center for Biologics Evaluation; and Research, Food and Drug Administration, Bethesda, MD, USA.; AOKI@CBER.FDA.GOV; Kaposi s sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is a herpesvirus linked to the development of Kaposi s sarcoma (KS), primary effusion lymphoma, and a proportion of Castleman s disease. KSHV encodes viral interleukin-6 (vIL-6), which is structurally homologous to human and muri
Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma [see comments]: Blood. 1999 Jun 15;93(12):4044-58. Unique Identifier : AIDSLINE MED/99290758; Monini P; Colombini S; Sturzl M; Goletti D; Cafaro A; Sgadari C; Butto S; Franco M; Leone P; Fais S; Leone P; Melucci-Vigo G; Chiozzini C; Carlini F; Ascherl G; Cornali E; Zietz C; Ramazzotti E; Ensoli F; Andreoni M; Pezzotti P; Rezza G; Yarchoan R; Gallo RC; Ensoli B; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; Patients with Kaposi s sarcoma (KS) have a human herpesvirus-8 (HHV-8) load higher than patients without KS and present a CD8(+) T-cell activation with production of Th1-type cytokines both in tissues and peripheral blood mononuclear cells (PBMC). Because in tissues of KS patients detection of inflammatory cytokines (
Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy.: Blood. 1999 Jun 15;93(12):4232-41. Unique Identifier : AIDSLINE MED/99290777; Ascherl G; Hohenadl C; Schatz O; Shumay E; Bogner J; Eckhart L; Tschachler E; Monini P; Ensoli B; Sturzl M; Department of Virology, Max Planck Institute for Biochemistry,; Martinsried, Germany.; Alterations in the vascular system and the onset of angioproliferative lesions such as Kaposi s sarcoma (KS) are common traits of human immunodeficiency virus-1 (HIV-1)-infected patients. To investigate possible factors involved in acquired immunodeficiency syndrome (AIDS)-associated vasculopathy and vascular malfunct
Disease progression in HIV-positive women with moderate to severe immunosuppression: the role of depression. Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders.: Behav Med. 1999 Spring;25(1):43-7. Unique Identifier : AIDSLINE MED/99226173; Vedhara K; Schifitto G; McDermott M; Department of Experimental Psychology, University of Bristol,; United Kingdom.; Thirty-seven HIV-positive women were recruited in a 2-year prospective investigation into the role of depression in HIV disease progression. All participants had CD4+ cell counts of 200 or less at baseline and at least 3 CD4+ cell counts during follow-up. Participants were evaluated semiannually for CD4+ lymphocyte co
Tuberculosis, human immunodeficiency virus infection, and malnutrition in Burundi.: Nutrition. 1999 Apr;15(4):289-93. Unique Identifier : AIDSLINE MED/99252919; Niyongabo T; Henzel D; Idi M; Nimubona S; Gikoro E; Melchior JC; Matheron S; Kamanfu G; Samb B; Messing B; Begue J; Aubry P; Larouze B; CHU Kamenge, Bujumbura, Burundi.; In order to compare the nutritional status of tuberculosis (TB) patients who were human immunodeficiency virus (HIV)-seropositive with those who were seronegative, we carried out a cross-sectional anthropometric and biochemical assessment, together with bioelectrical impedance analysis (BIA) of the nutritional status
Thrombotic events associated with megestrol acetate in patients with AIDS cachexia.: Nutrition. 1999 Apr;15(4):294-8. Unique Identifier : AIDSLINE MED/99252920; Koller E; Gibert C; Green L; Mann M; Bernstein B; Center for Drug Evaluation, US Food and Drug Administration,; Rockville, Maryland 20857, USA.
Tuberculosis, HIV infection, and malnutrition: an infernal trio in central Africa [editorial]: Nutrition. 1999 Apr;15(4):321-2. Unique Identifier : AIDSLINE MED/99252924; Perronne C
Seroprevalence of Helicobacter pylori infection in patients with hepatitis B.: Br J Biomed Sci. 1998 Sep;55(3):176-8. Unique Identifier : AIDSLINE MED/99295477; Fan XG; Zou YY; Wu AH; Li TG; Hu GL; Zhang Z; Department of Infectious Diseases, Xiangya Hospital, Hunan; Medical University, Changsha, Hunan, People's Republic of China.; Helicobacter pylori infection has been investigated extensively in immunocompromised hosts, such as those with acquired immunodeficiency syndrome (AIDS) and organ transplant recipients. However, few reports on H. pylori prevalence in individuals with chronic HBV infection are available. The aim of this serological stu
Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.: Mol Membr Biol. 1998 Oct-Dec;15(4):203-11. Unique Identifier : AIDSLINE MED/99187471; Ritzel MW; Yao SY; Ng AM; Mackey JR; Cass CE; Young JD; Department of Physiology, University of Alberta, Edmonton,; Canada.; Two Na(+)-dependent nucleoside transporters implicated in adenosine and uridine transport in mammalian cells are distinguished functionally on the basis of substrate specificity: CNT1 is selective for pyrimidine nucleosides but also transports adenosine; CNT2 (also termed SPNT) is selective for purine nucleosides but
Medical Outcomes Trust Conference presents dramatic advances in patient-based outcomes assessment and potential applications in accreditation.: Jt Comm J Qual Improv. 1999 Apr;25(4):207-18. Unique Identifier : AIDSLINE MED/99245596; Kaegi L; lkaegi@jcaho.org; BACKGROUND: At its fourth annual State-of-the-Art Health Outcomes Conference, November 2, 1998, the Medical Outcomes Trust (Boston) convened experts to review advances in outcomes assessment technology and potential applications in clinical trials, clinical practice, and accreditation. KEYNOTE ADDRESS: Future Directi
[Antiretroviral therapy and prevention of maternal-fetal transmission of HIV-1. Current and future strategies]: Arch Pediatr. 1999 May;6(5):556-65. Unique Identifier : AIDSLINE MED/99298952; Monpoux F; Bongain A; Berard E; Gillet JY; Service de pediatrie, Hopital de l'Archet II, Nice, France.; Azidothymidine is effective and recommended for the prophylaxis of vertical HIV transmission. Data regarding this treatment have been collected over the last decade, leading to it being widely prescribed despite the lack of information concerning its long term toxicity. Antiretroviral drug combinations administered du
[Attitude of pediatricians toward adopted children from foreign countries]: Arch Pediatr. 1999 May;6(5):569-72. Unique Identifier : AIDSLINE MED/99298954; Le Masme A; Federation de pediatrie, hopital Necker-Enfants-Malades,; Paris, France.; Adopted children from foreign countries represent a high risk population for infectious diseases, nutritional problems and neuro-developmental delay. Medical screening including clinical and biological evaluation is recommended after arrival.
[Accumulation of data about adolescence by nurses: period from 1983 to 1996]: Rev Lat Am Enfermagem. 1998 Jan;6(1):91-7. Unique Identifier : AIDSLINE MED/98254909; Cano MA; Ferriani M das G; Alves AC; Nakata CY; Departamento de Enfermagem Materno-Infantil e Saude Publica da; Escola de Enfermagem de Ribeirao Preto da Universidade de Sao; Paulo.; In the last ten years adolescence has been object of study of many researchers and considered by National and International Organizations as an age band with priority to actions of promotion, prevention and protection. Many factors contributed to this concern with adolescence, between them, we can emphasize the import
Upregulation of T-helper 1 cytokines and chemokine expression in post-transplant airway obliteration.: Am J Respir Crit Care Med. 1999 Jun;159(6):1910-7. Unique Identifier : AIDSLINE MED/99280651; Boehler A; Bai XH; Liu M; Cassivi S; Chamberlain D; Slutsky AS; Keshavjee S; Thoracic Surgery Research Laboratory, The Toronto Hospital and; Samuel Lunenfeld Research Institute, Mount Sinai Hospital,; University of Toronto, Ontario, Canada.; The major obstacle to long-term survival after lung transplantation is chronic graft dysfunction manifest as bronchiolitis obliterans. Since the early stages are characterized by proliferation of itinerant cells (lymphocytes and macrophages), we hypothesized that cytokines and chemokines may play a role in the develop
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension.: Unique Identifier : AIDSLINE MED/99280653; Tuder RM; Cool CD; Geraci MW; Wang J; Abman SH; Wright L; Badesch D; Voelkel NF
Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy.: Am J Respir Crit Care Med. 1999 Jun;159(6):2009-13. Unique Identifier : AIDSLINE MED/99280665; Naccache JM; Antoine M; Wislez M; Fleury-Feith J; Oksenhendler E; Mayaud C; Cadranel J; Services de Pneumologie et de Reanimation Respiratoire,; d'Anatomie-Pathologique, et d'Histologie Biologie Tumorale,; Hopital Tenon, Paris, France.; We report two cases of HIV-infected patients who presented with diffuse interstitial micronodular lesions on chest X-ray after institution of protease inhibitor-containing highly active antiretroviral therapy (HAART). Granulomatous pulmonary disorder mimicking sarcoidosis was diagnosed on histopathological studies rev
Transcontinental spread of multidrug-resistant Mycobacterium bovis.: Am J Respir Crit Care Med. 1999 Jun;159(6):2014-7. Unique Identifier : AIDSLINE MED/99280666; Long R; Nobert E; Chomyc S; van Embden J; McNamee C; Duran RR; Talbot J; Fanning A; Departments of Medicine, Medical Microbiology, and Surgery,; University of Alberta, Edmonton, Alberta, Canada.; Globally, the proportion of all cases of tuberculosis (TB) caused by drug-resistant strains is increasing. We report the case of a Canadian citizen who acquired a highly drug-resistant strain of Mycobacterium bovis while visiting a relative with AIDS-related tuberculosis in Spain . T
The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population.: Am J Respir Crit Care Med. 1999 Jun;159(6):2021-3. Unique Identifier : AIDSLINE MED/99280668; Hizawa N; Yamaguchi E; Furuya K; Jinushi E; Ito A; Kawakami Y; First Department of Medicine, School of Medicine, Hokkaido; University, Sapporo, Japan. nhizawa@med.hoki.dai.ac.jp; A number of chemokines are produced by alveolar cells in the course of inflammatory reactions of sarcoidosis. C-C chemokine receptor 2 (CCR2) is a prominent receptor for the monocyte chemoattractant protein (MCP) group of C-C chemokines. A transition causing a valine to isoleucine substitution in transmembrane domain
A trans-receptor mechanism for infection of CD4-negative cells by human immunodeficiency virus type 1.: Curr Biol. 1999 May 20;9(10):547-50. Unique Identifier : AIDSLINE MED/99272742; Speck RF; Esser U; Penn ML; Eckstein DA; Pulliam L; Chan SY; Goldsmith MA; Gladstone Institute of Virology and Immunology, PO Box 419100,; San Francisco, California 94141, USA.; Chemokine receptors, particularly CCR5 and CXCR4, act as essential coreceptors in concert with CD4 for cellular entry by human immunodeficiency virus type 1 (HIV-1; reviewed in [1]). But infection of CD4(-) cells has also been encountered in various tissues in vivo, including astrocytes, neurons and microvascular endo
Nonsurgical treatment of osteoarticular tuberculosis. A retrospective study in 143 adults.: Rev Rhum Engl Ed. 1999 Jan;66(1):24-8. Unique Identifier : AIDSLINE MED/99155720; Pertuiset E; Beaudreuil J; Horusitzky A; Liote F; Kemiche F; Richette P; Clerc-Weyl D; Cerf-Payrastre I; Dorfmann H; Glowinski J; Crouzet J; Ziza JM; Bardin T; Meyer O; Dryll A; Kahn MF; Kuntz D; Rheumatology Unit, Viggo Petersen Center, Lariboisiere Teaching; Hospital, Paris, France.; OBJECTIVE AND METHODS: Data are sparse on nonsurgical treatments currently used for osteoarticular tuberculosis in industrialized countries. We conducted a multicenter retrospective study in the Paris urban area, France , in 206 cases of osteoarticular tuberculosis documented by exa
Preferential loss of large neocortical neurons during HIV infection: a study of the size distribution of neocortical neurons in the human brain.: Brain Res. 1999 May 15;828(1-2):119-26. Unique Identifier : AIDSLINE MED/99255490; Fischer CP; Jorgen G Gundersen H; Pakkenberg B; Neurological Research Laboratory, Bartholin Institute,; Kommunehospitalet, DK-1399, Copenhagen K, Denmark.; The infection with human immunodeficiency virus (HIV) is associated with a global and severe loss of neocortical neurons. However, there is limited knowledge concerning whether all neurons are equally susceptible to damage during HIV infection. Other studies have reported low vulnerability of small interneurons and hi
Elevated adenosine deaminase activity in patients with HIV and tuberculous peritonitis.: Eur J Gastroenterol Hepatol. 1999 Mar;11(3):337-41. Unique Identifier : AIDSLINE MED/99264004; Sathar MA; Ungerer JP; Lockhat F; Simjee AE; Gouws E; Department of Medicine, University of Natal/King Edward VIII; Hospital, Durban, South Africa.; OBJECTIVE: To evaluate the diagnostic potential of the ADA(T), ADA isoenzymes (ADA1 and ADA2) and the interferon-gamma (IFN-gamma) test in HIV-seropositive patients with tuberculous peritonitis. METHODS: Ascitic ADA(T), ADA1, ADA2 and IFN-gamma were prospectively evaluated in HIV-seronegative patients with tuberculous
[General paresis]: Ryoikibetsu Shokogun Shirizu. 1999;(23 Pt 1):318-23. Unique Identifier : AIDSLINE MED/99188395; Kitagawa Y; Department of Neurology, Tokai University Oiso Hospital.
[Adult T-cell leukemia]: Ryoikibetsu Shokogun Shirizu. 1999;(23 Pt 1):38-41. Unique Identifier : AIDSLINE MED/99188324; Taguchi H; Third Department of Internal Medicine, Kochi Medical School.
[Acquired immunodeficiency syndrome (AIDS)]: Ryoikibetsu Shokogun Shirizu. 1999;(23 Pt 1):42-7. Unique Identifier : AIDSLINE MED/99188325; Kimura S; Department of Infection Control and Prevention, Graduate School; of Medicine, University of Tokyo.
[HHV8 infection (Kaposi's sarcoma)]: Ryoikibetsu Shokogun Shirizu. 1999;(23 Pt 1):51-4. Unique Identifier : AIDSLINE MED/99188327; Tachikawa N; AIDS Clinical Center, International Medical Center of Japan.
[Pyomyositis]: Ryoikibetsu Shokogun Shirizu. 1999;(23 Pt 1):589-92. Unique Identifier : AIDSLINE MED/99188472; Fujii T; Kimura M; Iwamoto A; War-surgery and Emergency Medicine, Ground Self-defense Force; Medical School.
Treatment for drug dependence.: Proc Assoc Am Physicians. 1999 Mar-Apr;111(2):126-30. Unique Identifier : AIDSLINE MED/99237156; Des Jarlais DC; Hubbard R; Chemical Dependency Institute, Beth Israel Medical Center, New; York, NY 10003, USA.; Drug abuse treatment is a major method for reducing the health and social problems associated with dependence on psychoactive drugs. Drug dependence is very well established in the United States , where cyclical rises and falls in the use of different drugs often occur. Heroin and cocai
Cytokine modulation of HIV-1 chemokine receptor expression [letter]: Nat Med. 1999 Jun;5(6):592-3. Unique Identifier : AIDSLINE MED/99297890; Landay AL; Patterson B; Andersson J
BMS offers some relief for Africa's AIDS crisis. Bristol Myers Squibb [news]: Nat Med. 1999 Jun;5(6):599. Unique Identifier : AIDSLINE MED/99297897; Birmingham K
HIV-1 and HAART: a time to cure, a time to kill [news; comment]: Nat Med. 1999 Jun;5(6):609-11. Unique Identifier : AIDSLINE MED/99297900; Saag MS; Kilby JM
Latent reservoirs of HIV infection: flushing with IL-2? [news; comment]: Nat Med. 1999 Jun;5(6):611-2. Unique Identifier : AIDSLINE MED/99297901; Cooper DA; Emery S
Is an HIV vaccine possible? [news; comment]: Nat Med. 1999 Jun;5(6):612-4. Unique Identifier : AIDSLINE MED/99297902; McMichael AJ; Hanke T
Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody.: Nat Med. 1999 Jun;5(6):629-34. Unique Identifier : AIDSLINE MED/99297910; Polack FP; Auwaerter PG; Lee SH; Nousari HC; Valsamakis A; Leiferman KM; Diwan A; Adams RJ; Griffin DE; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland, USA.; The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and
Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.: Nat Med. 1999 Jun;5(6):635-42. Unique Identifier : AIDSLINE MED/99297911; Reddy TR; Xu W; Mau JK; Goodwin CD; Suhasini M; Tang H; Frimpong K; Rose DW; Wong-Staal F; Department of Medicine, University of California San Diego, La; Jolla 92093, USA.; The HIV-1 Rev protein facilitates the nuclear export of mRNA containing the Rev response element (RRE) through binding to the export receptor CRM-1. Here we show that a cellular nuclear protein, Sam68 (Src-associated protein in mitosis), specifically interacts with RRE and can partially substitute for as well as syner
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine [see comments]: Nat Med. 1999 Jun;5(6):643-50. Unique Identifier : AIDSLINE MED/99297912; Cafaro A; Caputo A; Fracasso C; Maggiorella MT; Goletti D; Baroncelli S; Pace M; Sernicola L; Koanga-Mogtomo ML; Betti M; Borsetti A; Belli R; Akerblom L; Corrias F; Butto S; Heeney J; Verani P; Titti F; Ensoli B; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show that vaccination of cyno
Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy [see comments]: Nat Med. 1999 Jun;5(6):651-5. Unique Identifier : AIDSLINE MED/99297913; Chun TW; Engel D; Mizell SB; Hallahan CW; Fischette M; Park S; Davey RT Jr; Dybul M; Kovacs JA; Metcalf JA; Mican JM; Berrey MM; Corey L; Lane HC; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. twchun@nih.gov; The size of the pool of resting CD4+ T cells containing replication-competent HIV in the blood of patients receiving intermittent interleukin (IL)-2 plus highly active anti-retroviral therapy (HAART) was significantly lower than that of patients receiving HAART alone. Virus could not be isolated from the peripheral bl
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.: Nat Med. 1999 Jun;5(6):677-85. Unique Identifier : AIDSLINE MED/99297917; Lee PP; Yee C; Savage PA; Fong L; Brockstedt D; Weber JS; Johnson D; Swetter S; Thompson J; Greenberg PD; Roederer M; Davis MM; Howard Hughes Medical Institute/Department of Microbiology and; Immunology, Stanford University, California 94305, USA.; We identified circulating CD8+ T-cell populations specific for the tumor-associated antigens (TAAs) MART-1 (27-35) or tyrosinase (368-376) in six of eleven patients with metastatic melanoma using peptide/HLA-A*0201 tetramers. These TAA-specific populations were of two phenotypically distinct types: one, typical for me
When the unthinkable happens: post-exposure prophylaxis of HIV-contaminated percutaneous injuries.: J Can Dent Assoc. 1999 May;65(5):293-4. Unique Identifier : AIDSLINE MED/99309505; Petty TL; Foothills Medical Centre, Calgary.
Construction and characterization of recombinant VLPs and Semliki-Forest virus live vectors for comparative evaluation in the SHIV monkey model.: Biol Chem. 1999 Mar;380(3):341-52. Unique Identifier : AIDSLINE MED/99237848; Notka F; Stahl-Hennig C; Dittmer U; Wolf H; Wagner R; Institute of Medical Microbiology, University of Regensburg,; Germany.; For testing of recombinant virus-like particles (VLPs) in the SHIV monkey model, SIVmac239 Pr56gag precursor-based pseudovirions were modified by HIV-1 gp160 derived peptides. First, well-characterized epitopes from the HIV-1 envelope glycoprotein were inserted into the Pr56gag precursor by replacing defined regions t
Development of HIV/AIDS vaccine using chimeric gag-env virus-like particles.: Biol Chem. 1999 Mar;380(3):353-64. Unique Identifier : AIDSLINE MED/99237849; Kang CY; Luo L; Wainberg MA; Li Y; Western Science Centre, The University of Western Ontario,; London, Canada.; We attempted to develop a candidate HIV/AIDS vaccine, by using unprocessed HIV-2 gag pr45 precursor protein. We found that a 45 kDa unprocessed HIV-2 gag precursor protein (pr45), with a deletion of a portion of the viral protease, assembles as virus-like particles (VLP). We mapped the functional domain of HIV-2 gag V
A disulfide-bound HIV-1 V3 loop sequence on the surface of human rhinovirus 14 induces neutralizing responses against HIV-1.: Biol Chem. 1999 Mar;380(3):365-74. Unique Identifier : AIDSLINE MED/99237850; Zhang A; Geisler SC; Smith AD; Resnick DA; Li ML; Wang CY; Looney DJ; Wong-Staal F; Arnold E; Arnold GF; Center for Advanced Biotechnology and Medicine and Department of; Chemistry, Rutgers University, Piscataway, NJ 08854, USA.; An immunogenic sequence from the V3 loop of the MN isolate of human immunodeficiency virus type 1 (HIV-1), His-Ile-Gly-Pro-Gly-Arg-Ala-Phe, was transplanted onto a surface loop of the VP2 capsid protein of human rhinovirus 14. To optimize for virus viability and immunogenicity of the transplanted sequence, the HIV seq
DNA-plasmids of HIV-1 induce systemic and mucosal immune responses.: Biol Chem. 1999 Mar;380(3):375-9. Unique Identifier : AIDSLINE MED/99237851; Asakura Y; Lundholm P; Kjerrstrom A; Benthin R; Lucht E; Fukushima J; Schwartz S; Okuda K; Wahren B; Hinkula J; Swedish Institute for Infectious Disease Control, Microbiology; and Tumorbiology Center, Karolinska Institute, Stockholm.; DNA-based immunization has been shown to induce protective immunity against several microbial pathogens including HIV-1. Several routes of DNA vaccination have been exploited. However, the properties of the immune responses seem to differ with the different routes used for DNA delivery, ultimately affecting the outcom
Sexually transmitted disease (STD) and acquired immunodeficiency syndrome (AIDS) in South East Asia.: Clin Dermatol. 1999 Mar-Apr;17(2):127-35; discussion 105-6. Unique Identifier : AIDSLINE MED/99260854; Ismail R; Department of Medicine, University of Malaya, Kuala Lumpur,; Malaysia.
Kaposi's sarcoma in Africa.: Clin Dermatol. 1999 Mar-Apr;17(2):197-207; discussion 105-6. Unique Identifier : AIDSLINE MED/99260861; Matondo P; Department of Medicine, School of Medicine, University Teaching; Hospital, Lusaka, Zambia.
Coexistence of allergic contact dermatitis and granuloma annulare in an HIV-1-infected patient: A casual association? [letter]: Am J Contact Dermat. 1999 Jun;10(2):100-1. Unique Identifier : AIDSLINE MED/99286342; Munoz-Perez MA; Garcia-Bravo B; Rodriguez-Pichardo A; Camacho F
CNS as an HIV-1 reservoir; BBB and drug delivery.: J Neurovirol. 1999 Apr;5(2):113-4. Unique Identifier : AIDSLINE MED/99253891; Kerza-Kwiatecki AP; Amini S; Division of Convulsive, Infectious, and Immune Disorders,; National Institute of Neurological Disorders and Stroke, National; Institutes of Health, Bethesda, Maryland 20892, USA.
Replication of different clones of human immunodeficiency virus type 1 in primary fetal human astrocytes: enhancement of viral gene expression by Nef.: J Neurovirol. 1999 Apr;5(2):115-24. Unique Identifier : AIDSLINE MED/99253892; Bencheikh M; Bentsman G; Sarkissian N; Canki M; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, Columbia University, New York, USA.; Dementia is a common complication of AIDS which is associated with human immunodeficiency virus type 1 (HIV-1) infection of brain macrophages and microglia. Recent studies have shown that astrocytes are also infected in the brain but HIV-1 replication in these cells is restricted. To determine virus specificity of thi
Detection and typing of JC virus in autopsy brains and extraneural organs of AIDS patients and non-immunocompromised individuals.: J Neurovirol. 1999 Apr;5(2):125-33. Unique Identifier : AIDSLINE GENBANK/AF048698; Caldarelli-Stefano R; Vago L; Omodeo-Zorini E; Mediati M; Losciale L; Nebuloni M; Costanzi G; Ferrante P; Laboratory of Biology, Don C. Gnocchi Foundation, IRCCS, Milan,; Italy.; The distribution of JC virus (JCV) variants in the brain, lung, liver, kidney, spleen and lymph nodes collected at autopsy from AIDS patients with (Group A: 10 Ss) and without (Group B: 5 Ss) progressive multifocal leukoencephalopathy (PML) and from HIV-negative patients (Group C: 5 Ss), was examined by amplifying the
Impact of cerebrospinal fluid PCR on the management of HIV-infected patients with varicella-zoster virus infection of the central nervous system.: J Neurovirol. 1999 Apr;5(2):172-80. Unique Identifier : AIDSLINE MED/99253898; Iten A; Chatelard P; Vuadens P; Miklossy J; Meuli R; Sahli R; Meylan PR; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.; Over a 2 year period, we identified five HIV-infected patients who presented with central nervous system infection caused by varicella-zoster virus, three with myelitits, and two with meningoencephalitis. All five patients were profoundly immunocompromised. Clinical presentation of these patients overlapped to a signi
Lack of association between Borna disease virus infection and neurological disorders among HIV-infected individuals.: J Neurovirol. 1999 Apr;5(2):190-5. Unique Identifier : AIDSLINE MED/99253900; Bachmann S; Caplazi P; Fischer M; Ehrensperger F; Cone RW; Department of Internal Medicine, University Hospital, Zurich,; Switzerland.; Viruses have been proposed as etiologic cofactors in the pathogenesis of HIV-related neurological disease. To investigate the etiologic potential of Borna disease virus (BDV) in these disorders, two populations were studied: (1) 27 prospectively identified patients with various neurological disorders were evaluated wi
Recombinant virus vaccination against "self" antigens using anchor-fixed immunogens.: Cancer Res. 1999 Jun 1;59(11):2536-40. Unique Identifier : AIDSLINE MED/99290636; Irvine KR; Parkhurst MR; Shulman EP; Tupesis JP; Custer M; Touloukian CE; Robbins PF; Yafal AG; Greenhalgh P; Sutmuller RP; Offringa R; Rosenberg SA; Restifo NP; Surgery Branch, National Cancer Institute, NIH, Bethesda,; Maryland 20892, USA.; To study the induction of anti- self CD8+ T-cell reactivity against the tumor antigen gp100, we used a mouse transgenic for a chimeric HLA-A*0201/H-2 Kb molecule (A2/Kb). We immunized the mice with a recombinant vaccinia virus encoding a form of gp100 that had been modified at position 210 (from a threonine to a meth
Epidemiology of respiratory infectious diseases.: Curr Opin Pulm Med. 1999 May;5(3):128-35. Unique Identifier : AIDSLINE MED/99245420; Enarson DA; Chretien J; International Union Against Tuberculosis and Lung Disease, Paris,; France.; Respiratory infections are a frequent burden to health despite the fact that cost-effective methods for their prevention and cure are available. Acute respiratory infections in children under 5 years of age are the most frequent cause of death from lung disease globally, causing more than 4 million deaths annually. Tu
Pulmonary tuberculosis.: Curr Opin Pulm Med. 1999 May;5(3):143-50. Unique Identifier : AIDSLINE MED/99245422; Hirsch CS; Johnson JL; Ellner JJ; Case Western Reserve University, Department of Medicine,; Cleveland, OH 44106-4984, USA.; Pulmonary tuberculosis is a major cause of morbidity and mortality worldwide, resulting in the greatest number of deaths due to any one single infectious agent. This trend is due, at least in part, to increasing numbers of individuals co-infected with HIV and Mycobacterium tuberculosis (MTB). Concerted efforts between
Pyogenic lung infections.: Curr Opin Pulm Med. 1999 May;5(3):151-6. Unique Identifier : AIDSLINE MED/99245423; Mwandumba HC; Beeching NJ; Regional Infectious Disease Unit, University Hospital Aintree,; Liverpool, UK.; Pyogenic lung infections still occur despite the availability of effective antibiotics for the treatment of patients with acute bacterial pneumonia. Our understanding of the pathogenesis and management of these conditions has steadily improved over the past few decades, although some areas remain obscure. The effect o
Respiratory infections in immunocompromised patients.: Curr Opin Pulm Med. 1999 May;5(3):168-73. Unique Identifier : AIDSLINE MED/99245426; Barry SM; Lipman MC; Johnson MA; Prentice HG; Department of Thoracic Medicine, Royal Free Hospital, London, UK.; HIV disease has been dramatically reduced in the developed world by the introduction of highly active antiretroviral therapy, with implications that prophylactic therapy against opportunistic infections may be stopped; however, tuberculosis is an escalating problem in the HIV-infected and HIV-noninfected populations w
The utility of CT in imaging chest infections in HIV-negative patients.: Curr Opin Pulm Med. 1999 May;5(3):179-84. Unique Identifier : AIDSLINE MED/99245428; Richenberg J; Harvey C; Department of Radiology, St. Paul's Hospital, Vancouver, British; Columbia, Canada.; This article focuses on the recent developments in CT imaging of chest infections in patients who are immunocompetent or immunosuppressed, but not infected with HIV. Although simple viral and bacterial infections predominate, more exotic infections are now being encountered. First, a re-emergence of mycobacterial di
Reduction in recidivism of incarcerated women through primary care, peer counseling, and discharge planning.: J Womens Health. 1999 Apr;8(3):409-15. Unique Identifier : AIDSLINE MED/99256927; Vigilante KC; Flynn MM; Affleck PC; Stunkle JC; Merriman NA; Flanigan TP; Mitty JA; Rich JD; The Miriam Hospital, Brown University School of Medicine,; Providence, Rhode Island 02906, USA.; Prior to release from the Rhode Island state prison, women at the highest risk for reincarceration and HIV infection are assigned to the Women s HIV/Prison Prevention Program (WHPPP), a discharge program designed to reduce the likelihood of reincarceration and HIV infection. Candidates for the WHPPP must meet at least
Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.: Microbiol Mol Biol Rev. 1999 Jun;63(2):308-33. Unique Identifier : AIDSLINE MED/99286370; Hollsberg P; Department of Medical Microbiology and Immunology, Aarhus; University, Aarhus, Denmark. ph@microbiology.au.dk; The interactions between human T-cell lymphotropic virus type I (HTLV-I) and the cellular immune system can be divided into viral interference with functions of the infected host T cell and the subsequent interactions between the infected T cell and the cellular immune system. HTLV-I-mediated activation of the infecte
Multidrug-resistant tuberculosis in Alberta and British Columbia, 1989 to 1998.: Can Respir J. 1999 Mar-Apr;6(2):155-60. Unique Identifier : AIDSLINE MED/99255768; Hersi A; Elwood K; Cowie R; Kunimoto D; Long R; Department of Medicine, University of Alberta, Edmonton, Alberta,; Canada.; OBJECTIVE: To describe the extent of the problem of multidrug-resistant tuberculosis (MDR-TB) in Alberta and British Columbia from 1989 to 1998. DESIGN: A retrospective, population-based descriptive study of all notified MDR-TB cases in the context of all notified TB cases, all notified culture-positive TB cases and a
Inhibitory constituents against HIV-1 protease from Agastache rugosa.: Arch Pharm Res. 1999 Feb;22(1):75-7. Unique Identifier : AIDSLINE MED/99170180; Min BS; Hattori M; Lee HK; Kim YH; College of Pharmacy, Chungnam National University, Taejon, Korea.; Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of Agastache rugosa (Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with IC50 values of 360 and 87 microM, respectively.
Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes.: Clin Immunol. 1999 Jun;91(3):254-62. Unique Identifier : AIDSLINE MED/99298508; Patterson BK; Czerniewski M; Andersson J; Sullivan Y; Su F; Jiyamapa D; Burki Z; Landay A; Department of Obstetrics/Gynecology, Northwestern University; Medical School, Chicago, Illinois 60611, USA. bpatters@nmh.org; HIV-1 transmission and disease progression is, in general, characterized by initial predominance of macrophage tropic, non-syncytium-inducing strains followed by a switch to T-cell tropic, syncytium-inducing strains. Using sensitive, quantitative kinetic RT-PCR, we examined cytokine regulation of tropism-specific HIV-
Decreased dipeptidyl peptidase IV enzyme activity of plasma soluble CD26 and its inverse correlation with HIV-1 RNA in HIV-1 infected individuals.: Clin Immunol. 1999 Jun;91(3):283-95. Unique Identifier : AIDSLINE MED/99298511; Hosono O; Homma T; Kobayashi H; Munakata Y; Nojima Y; Iwamoto A; Morimoto C; Department of Clinical Immunology, University of Tokyo, Japan.; Human plasma contains soluble CD26/dipeptidyl peptidase IV (sCD26/DPPIV) although its physiological significance remains unclear. To determine whether the plasma sCD26 levels have clinical relevance in HIV-1 infected individuals, the concentration and DPPIV enzyme activity of plasma sCD26 were measured. While there is
Effects of SIVmac infection on peripheral blood CD4+CD8+ T lymphocytes in cynomolgus macaques.: Clin Immunol. 1999 Jun;91(3):321-9. Unique Identifier : AIDSLINE MED/99298516; Akari H; Nam KH; Mori K; Otani I; Shibata H; Adachi A; Terao K; Yoshikawa Y; Tsukuba Primate Center, National Institute of Infectious; Diseases, Ibaraki, Japan.; We have previously reported that CD4+CD8+ double-positive (DP) T cells with a resting memory phenotype exist in a substantial proportion of peripheral blood lymphocytes of adult cynomolgus macaques. In this study, we examined the effects of simian immunodeficiency virus of macaque (SIVmac) infection on DP T cells. In
Phenotype and cytokine profile of Schistosoma mansoni specific T cell lines and clones derived from schistosomiasis patients with distinct clinical forms.: Clin Immunol. 1999 Jun;91(3):338-44. Unique Identifier : AIDSLINE MED/99298518; Contigli C; Silva-Teixeira DN; Del Prete G; D'Elios MM; De Carli M; Manghetti M; Amedei A; Almerigogna F; Lambertucci JR; Goes AM; Departamento Bioquimica e Imunologia, Faculdade de Medicina,; Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; It is essential to distinguish the role of T lymphocytes on the physiopathology associated to more severe forms of schistosomiasis and on the immunomodulation that evolves in the majority of infected people. In this study, we generated Schistosoma mansoni-specific T cell lines and clones from patients with the acute a
Expression of costimulatory molecules CD80 and/or CD86 by a Kaposi's sarcoma tumor cell line induces differential T-cell activation and proliferation.: Clin Immunol. 1999 Jun;91(3):345-53. Unique Identifier : AIDSLINE MED/99298519; Foreman KE; Wrone-Smith T; Krueger AE; Nickoloff BJ; Department of Pathology, Cardinal Bernardin Cancer Center, Loyola; University Medical Center, Maywood, Illinois 60153-5385, USA.; During physiological stimulation of resting T-cells, at least two activation signals by antigen presenting cells are required. Besides the first antigen-specific signal, the second costimulatory signal involves CD80 and CD86 expressed by the antigen presenting cell. These costimulatory molecules have been suggested to
Transformation of guinea pig leukocytes by coinfection with human T-cell lymphotropic virus types I and II.: J Hum Virol. 1998 Jan-Feb;1(2):101-6. Unique Identifier : AIDSLINE MED/99211143; Murakami K; Hatakeyama N; Ikezoe T; Kubota T; Kubonishi I; Ohtsuki Y; Sawada T; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; OBJECTIVE: The susceptibility of guinea pigs to human T-cell lymphotropic virus (HTLV) infection and of their cardiac blood mononuclear cells (CBMCs) to HTLV-induced transformation were investigated. STUDY DESIGN/METHODS: Guinea pig CBMCs were cocultured with HTLV-infected cell lin
Post-HAART therapy research [editorial]: J Hum Virol. 1998 Jan-Feb;1(2):67-8. Unique Identifier : AIDSLINE MED/99211137; Gallo RC
Interferon downregulates CXCR4 (fusin) gene expression in peripheral blood mononuclear cells.: J Hum Virol. 1998 Jan-Feb;1(2):69-76. Unique Identifier : AIDSLINE MED/99211138; Shirazi Y; Pitha PM; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, Maryland, USA.; OBJECTIVE: Cytokines modulate human immunodeficiency virus type 1 (HIV-1) replication at multiple stages of its life cycle. We examined the effects of several HIV-1-stimulatory and HIV-1-inhibitory cytokines on CXCR4 (fusin) gene expression in lymphoid cells. STUDY DESIGN/METHODS: Peripheral blood mononuclear cells (P
Tumor necrosis factor alpha and human immunodeficiency virus-specific functional immune responses after immunization with Gp120-depleted, inactivated HIV-1 in incomplete Freund's adjuvant (REMUNE) in HIV-1-seropositive subjects.: J Hum Virol. 1998 Jan-Feb;1(2):77-81. Unique Identifier : AIDSLINE MED/99211139; Moss RB; Li L; Giermakowska WK; Lanza P; Turner JL; Wallace MR; Jensen FC; Richieri SP; Daigle AE; Theofan G; Carlo DJ; Immune Response Corporation, Carlsbad, California 92008, USA.; OBJECTIVE: We examined the relation between tumor necrosis factor-alpha (TNF-alpha) levels and human immunodeficiency virus type 1 (HIV-1)-specific functional immune responses, as measured by HIV-1 antigen-stimulated lymphocyte proliferation and beta-chemokine production after immunization with gp120-depleted, inactiv
AIDS-related Kaposi's sarcoma patients with visceral manifestations. Response to human chorionic gonadotropin preparations.: Unique Identifier : AIDSLINE MED/99211140; Hermans P; Clumeck N; Picard O; van Vooren JP; Duriez P; Zucman D; Bryant JL; Gill P; Lunardi-Iskandar Y; Gallo RC; OBJECTIVE: In vitro cell culture studies and a murine model for human Kaposi s sarcoma (KS) have shown that human chorionic gonadotropin (hCG)-associated factor (HAF) isolated from commercial hCG preparations has antiproliferative and cell killing effects on neoplastic KS cells, without toxic effects on normal endothe
Five human immunodeficiency virus type 1 phenotypic variants with different MT-2 cell tropisms correlate with prognostic markers of disease.: J Hum Virol. 1998 Jan-Feb;1(2):90-5. Unique Identifier : AIDSLINE MED/99211141; Nicastri E; Ercoli L; Sarmati L; Ventura L; Parisi SG; Ciapetti C; Montano M; Andreoni M; Department of Public Health and Cellular Biology, University Tor; Vergata, Rome, Italy.; OBJECTIVES: We correlated virologic and immunologic parameters of disease progression with cytopathogenicity of HIV isolates. STUDY DESIGN/METHODS: Human immunodeficiency virus type 1 (HIV-1) isolates from 207 patients with CD4+ cell counts
Prevalence of hepatitis G virus RNA in human immunodeficiency virus type 1-positive intravenous drug users.: J Hum Virol. 1998 Jan-Feb;1(2):96-100. Unique Identifier : AIDSLINE MED/99211142; Zehender G; De Maddalena C; Bosisio AB; Gianotto M; Santambrogio S; Moroni M; Galli M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy. zehender@imiucca.csi.unimi.it; OBJECTIVE: The aim of this study was to evaluate the prevalence of the new human flavivirus hepatitis G virus (HGV) in Italian intravenous drug users (IDUs) and its interaction with human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). STUDY DESIGN/METHODS: Seventy-nine IDUs with different clinical
The endless tragedy of pediatric AIDS [editorial]: J Hum Virol. 1999 Jan-Feb;2(1):1-2. Unique Identifier : AIDSLINE MED/99216600; Wainberg MA
Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2).: J Hum Virol. 1999 Jan-Feb;2(1):19-32. Unique Identifier : AIDSLINE GENBANK/AF045550; Burysek L; Yeow WS; Pitha PM; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, Maryland, USA.; OBJECTIVE: Human herpesvirus 8/Kaposi s sarcoma herpesvirus (HHV-8/KSHV) contains, in addition to genes required for viral replication, an unique set of nonstructural genes which may be part of viral mimicry and contribute to viral replication and pathogenesis in vivo. Among these, HHV-8 encodes four open reading fram
Cellular localization of human herpesvirus 8 in nonneoplastic lymphadenopathies and chronic interstitial pneumonitis by in situ polymerase chain reaction studies.: J Hum Virol. 1999 Jan-Feb;2(1):38-44. Unique Identifier : AIDSLINE MED/99216605; Trovato R; Luppi M; Barozzi P; Da Prato L; Maiorana A; Lico S; Marasca R; Torricelli P; Torelli G; Ceccherini-Nelli L; Department of Experimental Pathology, University of Pisa, Italy.; OBJECTIVES: To study the cellular localization of human herpesvirus 8 (HHV-8) in rare cases of HHV-8 infection from Italy that are associated neither with human immunodeficiency virus (HIV) infection nor Kaposi s sarcoma (KS). METHODS: The presence and distribution of HHV-8-infected
Relation between HIV-2 proviral load and CD4+ lymphocyte count differs in monotypic and dual HIV infections.: J Hum Virol. 1999 Jan-Feb;2(1):45-51. Unique Identifier : AIDSLINE MED/99216606; Sarr AD; Popper S; Thior I; Hamel DJ; Sankale JL; Siby T; Marlink R; Essex M; Mboup S; Kanki P; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115-6017, USA.; OBJECTIVE: To explore and compare the relations between proviral DNA load and CD4+ lymphocyte counts in both HIV-2 monotypic and HIV dual infection. STUDY DESIGN/METHODS: In Dakar, Senegal , where the HIV-1 and HIV-2 epidemics overlap, serum and peripheral blood mononuclear cell (P
Changes in circulating levels of HIV, CD4, and tissue expression of HIV in a patient with recent-onset ulcerative colitis treated by surgery. Case report.: J Hum Virol. 1999 Jan-Feb;2(1):52-7. Unique Identifier : AIDSLINE MED/99216607; Silver S; Wahl SM; Orkin BA; Orenstein JM; Department of Pathology, George Washington University School of; Medicine and Health Sciences, Washington DC 20037, USA.; OBJECTIVE: To determine CD4+ T-cell count and circulating and tissue levels of HIV before and after surgery in a patient with recent-onset ulcerative colitis. STUDY DESIGN/METHODS: CD4 lymphocytes and circulating and tissue HIV RNA levels were measured in an HIV-infected patient with ulcerative colitis before and afte
HIV vaccines and prevention in a world without Mary Lou Clements-Mann and Jonathan Mann.: J Hum Virol. 1999 Jan-Feb;2(1):58-60. Unique Identifier : AIDSLINE MED/99216608; Levine MM; Curran J
A personal perspective on HIV-AIDS research.: J Hum Virol. 1999 Jan-Feb;2(1):8-18. Unique Identifier : AIDSLINE MED/99216602; Gallo RC
Isolated severe right atrial dilatation demonstrated on planar TI-201 myocardial imaging.: Clin Nucl Med. 1999 May;24(5):368-9. Unique Identifier : AIDSLINE MED/99247447; Kumar M; Abdel-Dayem HM; Department of Radiology, Section of Nuclear Medicine, St.; Vincent's Hospital and Medical Center of New York, New York; Medical College at Valhalla, USA.
[Advances in the study of HIV/AIDS associated social behavior]: Chung Hua Yu Fang I Hsueh Tsa Chih. 1998 Mar;32(2):120-1. Unique Identifier : AIDSLINE MED/99256124; Li H; Zhang K
[Relationship between risk-taking behavior and knowledge for HIV infection among young men in Longchuan, Yunnan of China]: Chung Hua Yu Fang I Hsueh Tsa Chih. 1998 May;32(3):171-3. Unique Identifier : AIDSLINE MED/99256104; Wu Z; Zhang J; Dong L; Ministry of Health Center for AIDS Prevention and Control,; Chinese Academy of Preventive Medicine, Beijing.; OBJECTIVE: To study the relationship between characteristics of risk-taking behavior and knowledge level of HIV infection/AIDS and risk perception of HIV infection among young men in an AIDS epidemic area. METHODS: A cross-sectional survey was carried out among young men aged 18-29 years in 82 villages in Longchuan, Y
Kinetics of intracytoplasmic Th1 and Th2 cytokine production assessed by flow cytometry following in vitro activation of peripheral blood mononuclear cells.: Cytometry. 1999 Apr 1;35(4):318-28. Unique Identifier : AIDSLINE MED/99228185; Rostaing L; Tkaczuk J; Durand M; Peres C; Durand D; de Preval C; Ohayon E; Abbal M; Department of Multiorgan Transplantation, CHU Rangueil, Toulouse,; France.; BACKGROUND: Standard cytokine detection methods are unable to determine which cells are the producing cells. We report on the extent and under which conditions the multilabeling capability of flow cytometry (FCM) can bring new advances into the field. METHODS: Five different cytokines, interleukin-2 (
Surface antigen detection with non-fluorescent, antibody-coated microbeads: an alternative method compatible with conventional fluorochrome-based labeling.: Cytometry. 1999 May 1;36(1):27-35. Unique Identifier : AIDSLINE MED/99260467; Fortin M; Hugo P; PROCREA BioSciences Inc., Ville Mont-Royal, Quebec, Canada.; BACKGROUND: Our goal was to devise a new labeling technique allowing the flow cytometric detection of an additional cell surface marker without the need for a supplementary fluorochrome. METHODS: Non-fluorescent polystyrene latex microbeads (0.1 or 0.5 microm in diameter) were coated with monoclonal antibodies (mAbs)
New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users.: Drug Alcohol Depend. 1999 Apr 1;54(2):145-54. Unique Identifier : AIDSLINE MED/99231906; Krol A; Flynn C; Vlahov D; Miedema F; Coutinho RA; van Ameijden EJ; Division of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands.; Long-term effects of drug type and other drug use related risk factors on CD4+ cell decline were assessed in 224 HIV-infected injecting drug users (IDUs) from Baltimore (ALIVE), USA, and 63 IDUs from Amsterdam, The Netherlands . Higher frequencies of borrowing used injection eq
Proviral amplification of the Gypsy endogenous retrovirus of Drosophila melanogaster involves env-independent invasion of the female germline.: EMBO J. 1999 May 4;18(9):2659-69. Unique Identifier : AIDSLINE MED/99246288; Chalvet F; Teysset L; Terzian C; Prud'homme N; Santamaria P; Bucheton A; Pelisson A; C.G.M. du CNRS (UPR 9061), associe a l'Universite P. et M.; Curie Paris VI, 91198 Gif-sur-Yvette Cedex, France.; Gypsy is an infectious endogenous retrovirus of Drosophila melanogaster. The gypsy proviruses replicate very efficiently in the genome of the progeny of females homozygous for permissive alleles of the flamenco gene. This replicative transposition is correlated with derepression of gypsy expression, specifically in th
Electrophoretic karyotyping and triazole susceptibility of Candida glabrata clinical isolates.: Eur J Clin Microbiol Infect Dis. 1999 Mar;18(3):184-7. Unique Identifier : AIDSLINE MED/99283943; Barchiesi F; Falconi Di Francesco L; Arzeni D; Caselli F; Gallo D; Scalise G; Istituto di Malattie Infettive e Medicina Pubblica, Universita; degli Studi di Ancona, Ospedale Umberto I, Italy.; cmalinf@popcsi.unian.it; A series of 35 strains of Candida glabrata isolated from 29 subjects (5 AIDS patients and 24 HIV-seronegative individuals) were typed by electrophoretic karyotyping and tested for their susceptibilities to both fluconazole and itraconazole. Almost every individual harboured his/her own specific isolate (DNA type). Nei
Vibrio cholerae O2 sepsis in a patient with AIDS.: Eur J Clin Microbiol Infect Dis. 1999 Mar;18(3):203-5. Unique Identifier : AIDSLINE MED/99283947; Farina C; Luzzi I; Lorenzi N; Unita Operativa Microbiologia e Virologia, Azienda Ospedaliera; Ospedali Riuniti di Bergamo, Italy.; Vibrio cholerae strains other than O1 and 0139 (non-O1 Vibrio cholerae) are associated with sporadic diarrheal disorders and limited outbreaks of diarrhea and have often been reported in association with extraintestinal infections. The following is a presentation of a fatal case of non-O1 Vibrio cholerae septicemia wi
Increased adherence of fluconazole-resistant isolates of Candida species to explanted esophageal mucosa.: Eur J Clin Microbiol Infect Dis. 1999 Mar;18(3):213-6. Unique Identifier : AIDSLINE MED/99283950; Lyman CA; Garrett KF; Peter J; Gonzalez C; Walsh TJ; Immunocompromised Host Section, Pediatric Oncology Branch,; National Cancer Institute, Bethesda, Maryland 20892, USA.; lymanc@mail.nih.gov; The adherence of fluconazole-resistant and fluconazole-susceptible isolates of Candida albicans to explanted rabbit esophageal mucosa was examined in vivo. Among six Candida albicans isolates collected from HIV-infected patients, three fluconazole-resistant (MIC > 64 microg/ml) isolates attached more avidly than three
Antagonistic activity of HIV-1 T helper peptides flanked by an unrelated carrier protein.: Eur J Immunol. 1999 May;29(5):1448-55. Unique Identifier : AIDSLINE MED/99285593; Fenoglio D; Li Pira G; De Berardinis P; Saverino D; Terranova MP; Ombra MN; Bracci L; Lozzi L; Viotti C; Guardiola J; Manca F; Department of Immunology, San Martino Hospital, University of; Genoa, Italy.; Antagonism is the ability of a modified antigenic peptide (altered peptide ligand, APL) to prevent CD4 T cell activation by the original peptide. Here we show that antagonistic activity can be conferred to peptides of HIV envelope glycoprotein gp120 and reverse transcriptase p66 by adding flanking polypeptide sequence
Activated T cells enter rat lymph nodes and Peyer's patches via high endothelial venules: survival by tissue-specific proliferation and preferential exit of CD8+ T cell progeny.: Eur J Immunol. 1999 May;29(5):1487-95. Unique Identifier : AIDSLINE MED/99285597; Bode U; Duda C; Weidner F; Rodriguez-Palmero M; Wonigeit K; Pabst R; Westermann J; Center of Anatomy, Medical School of Hannover, Germany.; Bode.Ulrike@MH-Hannover.de; Activated T cells reach the lymph nodes via afferent lymphatics but it is unknown to what extent they also enter them directly via high endothelial venules (HEV). Little is known about the mechanism mediating the proliferation of activated T cells within lymphoid tissues in vivo or the subsequent fate of the progeny.
The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat.: Unique Identifier : AIDSLINE MED/99285600; Del Sorbo L; DeMartino A; Biancone L; Bussolati B; Conaldi PG; Toniolo A; Camussi G; HIV-1 Tat protein has been shown to induce chemotaxis and recruitment of monocytes. In the present study, we evaluated whether HIV-1 Tat protein was able to induce the synthesis of platelet-activating factor (PAF), which is a potent mediator of cell motility, and whether the synthesis of PAF was instrumental in trigge
Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes.: Eur J Immunol. 1999 May;29(5):1684-91. Unique Identifier : AIDSLINE MED/99285618; Kierszenbaum F; de Diego JL; Fresno M; Sztein MB; Department of Microbiology, Michigan State University, East; Lansing 48824, USA. kierszen@pilot.msu.edu; The Trypanosoma cruzi membrane glycoprotein AGC10 has been shown to alter some human macrophage functions (De Diego, J. L. et al., J. Immunol. 1997. 159: 4983-4989). We show here that, in the presence of AGC10, [3H]thymidine incorporation by normal human lymphocytes stimulated with anti-CD3 or phytohemagglutinin (PHA)
Induction of antibodies to methadone during methadone maintenance treatment of heroin addicts and its possible clinical implications.: Eur J Pharmacol. 1999 Mar 26;369(3):357-64. Unique Identifier : AIDSLINE MED/99239881; Gamaleya N; Dmitrieva I; Borg S; Ericcson N; Laboratory of Immunochemistry, Scientific Research Institute of; Addiction, Moscow, GSP, Russian Federation.; By means of two different types of enzyme-linked immunosorbent assay (ELISA) techniques, antibodies to methadone were detected in blood plasma of heroin addicts on methadone maintenance treatment. In 11-15% of cases immunoglobulin (Ig) M antibodies were detected, while IgG antibodies were observed in 33-40%. At least
Bronchoscopy and bronchoalveolar lavage findings in cross-country skiers with and without "ski asthma".: Unique Identifier : AIDSLINE MED/99247398; Sue-Chu M; Larsson L; Moen T; Rennard SI; Bjermer L; Dept of Lung Medicine, University Hospital, Trondheim, Norway.; Bronchial hyperresponsiveness to methacholine with asthma-like symptoms ( ski asthma ) is frequent in elite cross-country skiers. To further the understanding of ski asthma , 10 nonasthmatic, nonatopic controls and 30 adolescent elite skiers were investigated by bronchoscopy and bronchoalveolar lavage (BAL). Nine skin
Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.: Unique Identifier : AIDSLINE MED/99278257; Knolle PA; Schmitt E; Jin S; Germann T; Duchmann R; Hegenbarth S; Gerken G; Lohse AW; BACKGROUND & AIMS: Murine liver sinusoidal endothelial cells (LSECs) constitutively express accessory molecules and can present antigen to memory Th1 CD4(+) T cells. Using a T-cell receptor transgenic mouse line, we addressed the question whether LSECs can prime naive CD4(+) T cells. METHODS: Purified LSECs were in
Lamivudine for chronic hepatitis B: the magic bullet or just another bright prospect?: Gastroenterology. 1999 Jun;116(6):1498-9. Unique Identifier : AIDSLINE MED/99278268; Kowdley KV
[Response of fetal macrophages in the placenta of pregnant HIV-positive patients with and without antiretroviral treatment]: Ginecol Obstet Mex. 1999 May;67:196-206. Unique Identifier : AIDSLINE MED/99291601; Villegas Castrejon H; Mayon Gonzalez J; Paredes Vivas Y; Karchmer S; Departamento de Microscopia Electronica, Instituto Nacional de; Perinatologia, Mex. D.F.; We studied the cellular answer of placentary macrophages in pregnant women seropositive to the virus of human immunodefficiency (VIH-1) treated with zidovudina ( AZT ) and didanosine (ddl). Twenty eight pregnant women were studies; there were four group
The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases.: Immunol Rev. 1999 Feb;167:257-74. Unique Identifier : AIDSLINE MED/99252825; Price P; Witt C; Allcock R; Sayer D; Garlepp M; Kok CC; French M; Mallal S; Christiansen F; Department of Clinical Immunology, Royal Perth Hospital, Western; Australia, Australia.; An individual s major histocompatibility complex (MHC) ancestral haplotype (AH) is the clearest single determinant of susceptibility to MHC associated immunopathological disease, as it defines the alleles carried at all loci in the MHC. However, the direct effects of any of the 150-200 genes that constitute the MHC ar
Major histocompatibility complex class I genes in primates: co-evolution with pathogens.: Immunol Rev. 1999 Feb;167:327-37. Unique Identifier : AIDSLINE MED/99252829; Vogel TU; Evans DT; Urvater JA; O'Connor DH; Hughes AL; Watkins DI; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715-1299, USA.; The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may h
Profiles of Th1 and Th2 cytokines after primary and secondary infection by Schistosoma mansoni in the semipermissive rat host.: Infect Immun. 1999 Jun;67(6):2713-9. Unique Identifier : AIDSLINE MED/99270926; Cetre C; Pierrot C; Cocude C; Lafitte S; Capron A; Capron M; Khalife J; Institut Pasteur de Lille, 59019 Lille Cedex, France.; catherine.cetre@pasteur-lille.fr; In contrast to most mouse strains, rats eliminate the primary schistosome burden around 4 weeks postinfection and subsequently develop protective immunity to reinfection. In rat schistosomiasis, we have shown predominant expression of a Th2-type cytokine response at the mRNA level after primary infection. In the prese
CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice.: Infect Immun. 1999 Jun;67(6):2804-9. Unique Identifier : AIDSLINE MED/99270937; Baker PJ; Dixon M; Evans RT; Dufour L; Johnson E; Roopenian DC; Biology Department, Bates College, Lewiston, Maine 04240, USA.; pbaker@abacus.bates.edu; In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss
Construction of a single-chain interleukin-12-expressing retroviral vector and its application in cytokine gene therapy against experimental coccidioidomycosis.: Infect Immun. 1999 Jun;67(6):2996-3001. Unique Identifier : AIDSLINE MED/99270963; Jiang C; Magee DM; Cox RA; Department of Clinical Investigation, Texas Center for Infectious; Disease, San Antonio, Texas 78223, USA.; chengyong.jiang@tdh.state.tx.us; T-cell-mediated immunity is an important determinant in protection against primary infection with Coccidioides immitis, a dimorphic fungal pathogen that causes the disease coccidioidomycosis . To determine if interleukin-12 (IL-12) gene therapy could potentiate host r
Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells.: Infect Immun. 1999 Jun;67(6):3014-8. Unique Identifier : AIDSLINE MED/99270966; Brunet LR; Sabin EA; Cheever AW; Kopf MA; Pearce EJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, New York 14853, USA.; During schistosomiasis, interleukin-5 (IL-5)-dependent eosinophil responses have been implicated in immunopathology, resistance to superinfection, synergistic interactions with chemotherapeutic agents, and the inductive phase of the egg-induced Th2 response. We examined these issues in IL-5-deficient (IL-5(-/-)) mice.
Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease.: Infect Immun. 1999 Jun;67(6):3031-9. Unique Identifier : AIDSLINE MED/99270969; Higgins LM; Frankel G; Douce G; Dougan G; MacDonald TT; Department of Paediatric Gastroenterology, St. Bartholomew's and; the Royal London School of Medicine and Dentistry, St.; Bartholomew's Hospital, London EC1A 7BE, United Kingdom.; Citrobacter rodentium is a classically noninvasive pathogen of mice that is similar to enteropathogenic Escherichia coli (EPEC) in man. Following oral infection of young mice, the organism colonizes the distal colon, and within 1 week the colonic mucosa doubles in thickness and there is massive epithelial cell hyperpl
Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells.: Infect Immun. 1999 Jun;67(6):3108-11. Unique Identifier : AIDSLINE MED/99270980; Bermudez LE; Petrofsky M; Kuzell Institute for Arthritis and Infectious Diseases,; California Pacific Medical Center Research Institute, San; Francisco, California 94115, USA. luizb@cooper.cpmc.org; The role of CD8(+) T cells was evaluated in a mouse model of disseminated Mycobacterium avium infection. C57BL/6J and C57BL/6Jbeta2-/- (beta2-/-) mice were infected intravenously, and the number of viable bacteria in each liver and spleen was determined. No significant difference between the number of bacteria in the
General assembly adopts changes in HIV/AIDS statute.: Iowa Med. 1999 May-Jun;89(3):11. Unique Identifier : AIDSLINE MED/99283628; Freeman J
IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.: J Biol Chem. 1999 May 28;274(22):15297-300. Unique Identifier : AIDSLINE MED/99269055; Chu ZL; Shin YA; Yang JM; DiDonato JA; Ballard DW; Howard Hughes Medical Institute, Vanderbilt University School of; Medicine, Nashville, Tennessee 37232-0295, USA.; The Tax oncoprotein of human T cell leukemia virus type 1 constitutively activates transcription factor NF-kappaB by a mechanism involving Tax-induced phosphorylation of IkappaBalpha, a labile cytoplasmic inhibitor of NF-kappaB. To trigger this signaling cascade, Tax associates stably with and persistently activates a
Identification of amino acid residues critical for aggregation of human CC chemokines macropha