HLA-derived peptides as novel immunomodulatory therapeutics.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

HLA-derived peptides as novel immunomodulatory therapeutics.

J Am Soc Nephrol. 1999 Jun;10(6):1346-55. Unique Identifier : AIDSLINE MED/99288721
Murphy B; Krensky AM; Department of Medicine, Mount Sinai School of Medicine, New York,; New York, USA.

Abstract: A growing body of experimental evidence demonstrates that synthetic peptides corresponding to linear sequences of MHC (HLA in humans) proteins have immunomodulatory effects in vitro and in vivo in animal models and in humans. Although the original concept was that these peptides inhibited antigen recognition at the MHC-T cell receptor interface via physical blockade, it is now clear that the mechanisms responsible for the myriad of functional effects are more complex. Recent findings show that some peptides affect signal transduction and cell cycle progression. Fragments of MHC molecules can dampen or downregulate immune responses via a variety of mechanisms. Some soluble MHC molecules or synthetic peptides are capable of inducing and maintaining immunologic tolerance in animals. This information suggests that synthetic peptides themselves or drugs mimicking their effects may represent a new class of immunotherapeutics.

Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal CD4-CD8 Ratio Genes, MHC Class I/*IMMUNOLOGY Human HLA Antigens/*IMMUNOLOGY Immunotherapy/METHODS Major Histocompatibility Complex/IMMUNOLOGY Oligopeptides/IMMUNOLOGY/*THERAPEUTIC USE Receptors, Antigen, T-Cell/IMMUNOLOGY/*THERAPEUTIC USE Sensitivity and Specificity Signal Peptides/IMMUNOLOGY Signal Transduction/PHYSIOLOGY Support, U.S. Gov't, P.H.S.
991030
A99A0952

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