The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus.

Mol Membr Biol. 1999 Jan-Mar;16(1):67-72. Unique Identifier : AIDSLINE MED/99265143
Willett BJ; Hosie MJ; Department of Veterinary Pathology, University of Glasgow; Veterinary School, UK.

Abstract: Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. This article reviews the evidence for the involvement of chemokine receptors in FIV infection and contrasts these findings with similar studies on the primate lentiviruses HIV and SIV (simian immunodeficiency virus).
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Amino Acid Sequence Animal Cats Dose-Response Relationship, Drug Feline Acquired Immunodeficiency Syndrome/*METABOLISM/VIROLOGY Hela Cells Human Immunodeficiency Virus, Feline/*PATHOGENICITY Molecular Sequence Data Mutation Receptors, CXCR4/ANTAGONISTS & INHIB/*PHYSIOLOGY Receptors, Virus/*PHYSIOLOGY Support, Non-U.S. Gov'tKWDjournalarticlereviewreview,tutorialaminoacidsequenceanimalcatsdose-responserelationship,drugfelineacquiredimmunodeficiencysyndrome/KWDmetabolism/virologyhelacellshumanimmunodeficiencyvirus,feline/KWDpathogenicitymolecularsequencedatamutationreceptors,cxcr4/antagonists&inhib/KWDphysiologyreceptors,virus/KWDphysiologysupport,non-uKWDsKWDgov't
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A99A0933

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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