Mycobacterium avium interaction with macrophages and intestinal epithelial cells.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Mycobacterium avium interaction with macrophages and intestinal epithelial cells.

Front Biosci. 1999 Jul 15;4:D582-8. Unique Identifier : AIDSLINE MED/99348569
Sangari FJ; Parker A; Bermudez LE; Kuzell Institute for Arthritis & Infectious Diseases, California; Pacific Medical Center Research Institute, 2200 Webster Street,; Suite 305, San Francisco, CA 94115, USA.

Abstract: Mycobacterium avium is an environmental microorganism that is adapted to live both in the environment (mainly in water and soil) and in bird, fish and mammal hosts. In humans, M. avium infection is seen in patients with some sort of immunosuppression, such as patients with chronic lung disease, and Acquired Immunodeficiency Syndrome. More recently, other populations were shown to be at risk to develop M. avium disease. For the majority of time, humans acquire M. avium through the intestinal tract where the bacterium comes in contact with and translocates the intestinal mucosa. M. avium possesses a unique manner to interact with the intestinal mucosa, and, following invasion, can enter and survive within macrophages and monocytes. Although in vitro entry seems to be dependent on binding to the complement receptor, this finding has not been observed in vivo where the bacterium appears to enter macrophages by alternative mechanisms. The bacterium appears to trigger little inflammatory response, and is able to adapt itself to different environments in the host.

Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL *Bacterial Translocation Human HIV-1/PATHOGENICITY Intestinal Mucosa/IMMUNOLOGY/*MICROBIOLOGY Macrophages/CYTOLOGY/*MICROBIOLOGY Mycobacterium avium/*CYTOLOGY/*PHYSIOLOGY/PATHOGENICITY Phagocytes/MICROBIOLOGY
991030
A99A0919

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .