Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases.

Bioorg Med Chem Lett. 1999 Apr 19;9(8):1179-84. Unique Identifier : AIDSLINE MED/99258861
Kurihara S; Tsumuraya T; Fujii I; Biomolecular Engineering Research Institute, Suita, Osaka, Japan.

Abstract: Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.
Keywords: JOURNAL ARTICLE Amino Acids, Diamino/*CHEMISTRY/*CHEMICAL SYNTHESIS/ *PHARMACOKINETICS *Drug Design HIV Protease Inhibitors/*CHEMISTRY/*CHEMICAL SYNTHESIS/ *PHARMACOKINETICS Models, ChemicalKWDjournalarticleaminoacids,diamino/KWDchemistry/KWDchemicalsynthesis/KWDpharmacokineticsKWDdrugdesignhivproteaseinhibitors/KWDchemistry/KWDchemicalsynthesis/KWDpharmacokineticsmodels,chemical
991030
A99A0910

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