Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.

Int J Mol Med. 1999 Jun;3(6):633-7. Unique Identifier : AIDSLINE MED/99274687
Sales ME; Espanol AJ; Sterin-Borda L; Borda E; de Bracco MM; Instituto de Oncologia Angel H. Roffo, Buenos Aires, Argentina.

Abstract: In this work we demostrate that IgA purified from HIV infected patients recognizes a band with a molecular weight corresponding to radiolabelled ileal muscarinic acethylcholine receptors (mAChR) by immunoblotting. HIV+-IgA triggers the signals that are the consequence of mAChR stimulation in the intestine, regulating protein kinase C (PKC) and nitric oxide synthase (NOS) activity as well as 3',5'-cyclic guanosine monophosphate (cGMP) formation. On the one hand PKC activation by HIV+-IgA induces NOS inhibition and as a consequence, low amounts of NO that could improve local immunosuppression in the intestine; on the other hand HIV+-IgA stimulates cGMP production which could potentiate ileal motility and loss of water/electrolytes involved in intestinal damage in AIDS.
Keywords: JOURNAL ARTICLE Animal Antibody Specificity Cyclic GMP/*METABOLISM Electrophoresis, Polyacrylamide Gel Enzyme Activation/DRUG EFFECTS Enzyme Inhibitors/PHARMACOLOGY Human HIV Infections/*IMMUNOLOGY IgA/BLOOD/*METABOLISM Ileum/METABOLISM Immunoblotting Male Nitric Oxide/*METABOLISM Nitric-Oxide Synthase/ANTAGONISTS & INHIB/METABOLISM Protein Kinase C/IMMUNOLOGY/*PHYSIOLOGY Rats Rats, Wistar Receptors, Muscarinic/*METABOLISM Signal Transduction Support, Non-U.S. Gov'tKWDjournalarticleanimalantibodyspecificitycyclicgmp/KWDmetabolismelectrophoresis,polyacrylamidegelenzymeactivation/drugeffectsenzymeinhibitors/pharmacologyhumanhivinfections/KWDimmunologyiga/blood/KWDmetabolismileum/metabolismimmunoblottingmalenitricoxide/KWDmetabolismnitric-oxidesynthase/antagonists&inhib/metabolismproteinkinasec/immunology/KWDphysiologyratsrats,wistarreceptors,muscarinic/KWDmetabolismsignaltransductionsupport,non-uKWDsKWDgov't
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