Enhanced IFN-gamma production in vitro by CD8+ T cells in hemophiliacs with AIDS as demonstrated on the single-cell level.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Enhanced IFN-gamma production in vitro by CD8+ T cells in hemophiliacs with AIDS as demonstrated on the single-cell level.

Clin Immunol. 1999 Jul;92(1):111-7. Unique Identifier : AIDSLINE MED/99343957
Pae Y; Minagawa H; Hayashi J; Kashiwagi S; Yanagi Y; Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Abstract: We examined T cells from HIV-infected hemophiliacs under antiviral therapy, on the single-cell level, for cytokine production in vitro in response to stimulation. The percentage of IL-2-producing cells was markedly decreased among both CD3+CD8- and CD3+CD8+ cells, while the proportion of IFN-gamma-producing cells was preserved among CD3+CD8- cells and increased among CD3+CD8+ cells in HIV+ subjects, compared with HIV-uninfected controls. The increase in IFN-gamma-producing CD8+ cells was accounted for by the expansion of CD8+CD28- cells among total CD8+ T cells and by the higher percentage of IFN-gamma-expressing cells among both CD8+CD28+ and CD8+CD28- cells in HIV+ individuals, compared with controls. The enhanced IFN-gamma production in CD8+ cells from individuals in the advanced phase of HIV infection might implicate the host's response to chronic viral infection or senescence of host CD8+ cells. Copyright 1999 Academic Press.

Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DRUG THERAPY Adolescence Adult Antigens, CD28/ANALYSIS Antiviral Agents/THERAPEUTIC USE CD8-Positive T-Lymphocytes/IMMUNOLOGY/*METABOLISM Hemophilia A/BLOOD/*COMPLICATIONS/*METABOLISM Human HIV/GENETICS HIV Seropositivity/BLOOD Interferon Type II/*BIOSYNTHESIS Interleukin-2/BIOSYNTHESIS Interleukin-4/BIOSYNTHESIS Male RNA, Viral/ANALYSIS Support, Non-U.S. Gov't T-Lymphocyte Subsets/METABOLISM
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