Partial nucleotide sequencing of the NS3/helicase region of hepatitis G virus to prove vertical transmission. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Partial nucleotide sequencing of the NS3/helicase region of hepatitis G virus to prove vertical transmission.

FEMS Microbiol Lett. 1999 Jun 15;175(2):273-9. Unique Identifier : AIDSLINE MED/99314157
Takayama S; Miura T; Tominaga T; Taki M; Matsuo S; Sugii S; Shimotohno K; Division of Laboratory Research, St. Marianna University; Yokohamashi Seibu Hospital, Kanagawa, Japan.; stakayam@mb.kcom.ne.jp

Abstract: To study non-parental transmission of hepatitis G virus and/or GB virus C (HGV/GBV-C), we sequenced and compared the NS3/helicase region of the virus for five HGV/GBV-C RNA-positive mothers and their 11 children who had experienced neither blood transfusion nor overt hepatitis and were negative for HBV, HCV and HIV, except in one mother coinfected with HCV. The nucleotide sequences of the familial HGV/GBV-C isolates showed high similarity of 99-100% (mean 99.8%, 100% at the deduced amino acid level) between mother and her child(ren) in each family. These findings strongly suggest the spontaneous occurrence of mother-to-child transmission of HGV/GBV-C as reported previously. They also suggest that nucleotide sequence analysis on the NS3/helicase region of HGV/GBV-C may be a useful tool to study HGV/GBV-C transmission.
Keywords: JOURNAL ARTICLE Adult Base Sequence Child Child, Preschool *Disease Transmission, Vertical Female Hepatitis Agents, GB/*GENETICS/IMMUNOLOGY/ISOLATION & PURIF Hepatitis Antibodies/BLOOD Hepatitis, Viral, Human/*TRANSMISSION/VIROLOGY Human Infant Infant, Newborn Molecular Sequence Data Phylogeny Pregnancy Pregnancy Complications, Infectious RNA, Viral/*BLOOD Sequence Analysis, DNA Support, Non-U.S. Gov't Viral Envelope Proteins/IMMUNOLOGY Viral Nonstructural Proteins/*GENETICSKWDjournalarticleadultbasesequencechildchild,preschoolKWDdiseasetransmission,verticalfemalehepatitisagents,gb/KWDgenetics/immunology/isolation&purifhepatitisantibodies/bloodhepatitis,viral,human/KWDtransmission/virologyhumaninfantinfant,newbornmolecularsequencedataphylogenypregnancypregnancycomplications,infectiousrna,viral/KWDbloodsequenceanalysis,dnasupport,non-uKWDsKWDgov'tviralenvelopeproteins/immunologyviralnonstructuralproteins/KWDgenetics
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