1999

Synthesis and HIV-1 inhibitory properties of new tetrahydrobenzoquinazolinedione and tetrahydrobenzocycloheptenuracil derivatives and of their thioxo analogues.: Unique Identifier : AIDSLINE MED/99312712; Macchia M; Antonelli G; Balsamo A
Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles.: Farmaco. 1999 Apr 30;54(4):255-64. Unique Identifier : AIDSLINE MED/99312714; Merino I; Monge A; Font M; Martinez de Irujo JJ; Alberdi E; Santiago E; Prieto I; Lasarte JJ; Sarobe P; Borras F; Departamento Quimica Organica y Farmaceutica, Universidad de; Navarra, Pamplona, Spain.; A set of new pyrimido[5,4-b]indole derivatives that are structurally related to some non-nucleside HIV-1 reverse transcriptase inhibitors were synthesized and biologically evaluated for their activity as inhibitors of wild and mutant HIV-1 RT types in an in vitro recombinant HIV-1 RT screening assay, as well as anti
Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia.: Am J Reprod Immunol. 1999 May;41(5):297-306. Unique Identifier : AIDSLINE MED/99305787; Saito S; Umekage H; Sakamoto Y; Sakai M; Tanebe K; Sasaki Y; Morikawa H; Department of Obstetrics and Gynecology, Toyama Medical and; Pharmaceutical University, Japan.; PROBLEM: To examine whether preeclampsia involves type-1 T-helper (TH1) immune hyperactivity. METHOD OF STUDY: Expression of HLA-DR, a cell-surface marker of activation, was analyzed on CD3+, CD4+, and CD8+ T cells in 15 preeclamptic patients and 15 normal pregnant women using flow cytometry. Additionally, peripheral
Vertical transmission of HIV: parameters which might affect infection of placental trophoblasts by HIV-1: a review. Biomed Group on the Study of in Utero Transmission of HIV 1.: Am J Reprod Immunol. 1999 May;41(5):312-9. Unique Identifier : AIDSLINE MED/99305789; Moussa M; Mognetti B; Dubanchet S; Menu E; Roques P; Gras G; Dormont D; Barre-Sinoussi F; Chaouat G; INSERM U 131, Cytokines et Immunoregulation, Hopital Antoine; Beclere, Clamart, France.; PROBLEM: To understand the mechanisms preventing and/or facilitating maternofetal transmission of human immunodeficiency virus (HIV)-1 across the placenta during pregnancy. METHODS OF STUDY: Current experimental data were reviewed. RESULTS AND CONCLUSIONS: The data about the production of cytokines by placental cells
Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids.: Biochemistry. 1999 Jul 6;38(27):8808-19. Unique Identifier : AIDSLINE MED/99321518; Short GF 3rd; Golovine SY; Hecht SM; Departments of Chemistry and Biology, University of Virginia,; Charlottesville, Virginia 22901, USA.; An in vitro protein synthesizing system was modified to facilitate the improved, site-specific incorporation of unnatural amino acids into proteins via readthrough of mRNA nonsense (UAG) codons by chemically misacylated suppressor tRNAs. The modified system included an S-30 extract derived from Escherichia coli that e
Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat.: Biochemistry. 1999 Jul 6;38(27):8826-30. Unique Identifier : AIDSLINE MED/99321520; Creaven M; Hans F; Mutskov V; Col E; Caron C; Dimitrov S; Khochbin S; Equipe de Chromatine et Expression des Genes, Equipe; d'Assemblage et Regulation de l'Appareil Genetique,; Laboratoire de Biologie Moleculaire et Cellulaire de la; Differenciation, INSERM U309, France.; Tip60, a cellular histone-acetyltransferase, is known to interact with the HIV-1-encoded transactivator protein, Tat. In this work, we show that the interaction of Tat with Tip60 efficiently inhibits the Tip60 histone-acetyltransferase activity. Besides its histone-acetyltransferase activity, Tip60 can undergo an auto
The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.: Biochemistry. 1999 Jul 13;38(28):8892-8. Unique Identifier : AIDSLINE PDB/1B92; Greenwald J; Le V; Butler SL; Bushman FD; Choe S; Structural Biology Laboratory, The Salk Institute, La Jolla,; California 92037, USA.; Replication of HIV-1 requires the covalent integration of the viral cDNA into the host chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the importance of a protein surface loop near the integrase active site using protein engineering and X-ray crystallography. We have redetermined the s
A care package for managing female sexual assault in genitourinary medicine.: Int J STD AIDS. 1999 May;10(5):283-9. Unique Identifier : AIDSLINE MED/99288761; Harrison JM; Murphy SM; Department of Genitourinary Medicine and Clinical Health; Psychology, St Mary's Hospital, London, UK.; This paper describes the development of a designated in-house service for the management of adult female victims of sexual assault within the Department of Genitourinary Medicine (GUM) at St Mary s Hospital, London. This was set up in 1994 as a need was identified by medical, nursing, psychological and health advising
Neisseria gonorrhoeae in Newcastle upon Tyne 1995-1997: increase in ciprofloxacin resistance.: Int J STD AIDS. 1999 May;10(5):290-3. Unique Identifier : AIDSLINE MED/99288762; Tayal SC; Sankar KN; Pattman RS; Watson PG; Galloway A; Department of Genito-Urinary Medicine, Newcastle General; Hospital, Newcastle upon Tyne, UK. STayal8144@aol.com; Fluoroquinolones and third generation cephalosporins are the most effective antimicrobial agents for the treatment of gonorrhoea. However, clinically significant resistance to fluoroquinolones in Neisseria gonorrhoeae has been reported worldwide including Britain. The aim of this analysis was to study the factors rela
Trends in HIV-related consultation in Dutch general practice.: Int J STD AIDS. 1999 May;10(5):294-9. Unique Identifier : AIDSLINE MED/99288763; Ros CC; Kerssens JJ; Foets M; Peters L; NIVEL (Netherlands Institute of Primary Health Care), Utrecht.; c.ros@nivel.nl; New medicine against AIDS and a possible changing attitude towards AIDS will affect the role of the general practitioner (GP). We aim to explore and assess the changing role of the GP in preventing and detecting AIDS, which will be done by providing insight into the changing numbers and content of HIV-related consulta
Seroprevalence of HIV, HBV, and syphilis and associated risk behaviours in male transvestites (Hijras) in Karachi, Pakistan.: Int J STD AIDS. 1999 May;10(5):300-4. Unique Identifier : AIDSLINE MED/99288764; Baqi S; Shah SA; Baig MA; Mujeeb SA; Memon A; Department of Medicine, Ziauddin University Hospital, Clifton,; Karachi, Pakistan.; In Pakistan , male sex workers are predominantly transvestites and transsexuals known as Hijras. In 1998 in Karachi, Pakistan, we studied the seroprevalence of HIV, HBsAg and syphilis and associated risk factors in Hijras. Study subjects were verbally administered a structured que
Bacterial vaginosis in lesbians: evidence for lack of sexual transmission.: Int J STD AIDS. 1999 May;10(5):305-8. Unique Identifier : AIDSLINE MED/99288765; McCaffrey M; Varney P; Evans B; Taylor-Robinson D; Department of Genitourinary Medicine, Imperial College School of; Medicine at St Mary's, Paddington, London, UK.; The effect of non-heterosexual factors on the vaginal flora has been studied. Ninety-one lesbians attending a specialist genitourinary medicine service for lesbians were studied. Bacterial vaginosis (BV) was diagnosed in 51.6% of them. While most of the women had previously had a male sexual partner, the presence of B
Treatment delay and reliance on private physicians among patients with sexually transmitted diseases in China.: Int J STD AIDS. 1999 May;10(5):309-15. Unique Identifier : AIDSLINE MED/99288766; Choi KH; Zheng X; Zhou H; Chen W; Mandel J; University of California-San Francisco, Center for AIDS; Prevention Studies, 94105, USA.; We examined health-care seeking practices among patients with sexually transmitted diseases (STDs) in south China . In 1995, we recruited a consecutive sample of 939 STD patients attending the STD clinics of the Municipal STD Control Centers of Guangzhou and Shenzhen, special econom
An epidemiological evaluation of the use of microbiological tools for identifying gonorrhoea infection networks.: Int J STD AIDS. 1999 May;10(5):316-23. Unique Identifier : AIDSLINE MED/99288767; Pierce RL; Thomas JC; Sparling PF; Fisher W; Davis RH; Alcorn T; Cohen M; Department of Epidemiology, School of Public Health, University; of North Carolina, Chapel Hill 27599-7400, USA.; We aimed to assess the utility of various techniques for identifying gonorrhoea infection networks. All residents of a non-metropolitan North Carolina county visiting a sexually transmitted disease (STD) clinic during a 17-month period were screened for gonorrhoea. Infection networks were estimated by serovar type com
Inadequate treatment for sexually transmitted diseases in the South African private health sector.: Unique Identifier : AIDSLINE MED/99288768; Connolly AM; Wilkinson D; Harrison A; Lurie M; Karim SS; Correct management of sexually transmitted diseases (STDs) is important for their control, and to reduce HIV transmission. Guidelines on syndromic management of STDs were introduced by the provincial Department of Health in KwaZulu/Natal (KZN) in South Africa in 1995. The drug tre
Routine reporting or sentinel surveys for HIV/AIDS surveillance in resource-poor settings: experience in South Africa, 1991-97.: Int J STD AIDS. 1999 May;10(5):328-30. Unique Identifier : AIDSLINE MED/99288769; Stuart JM; Irlam JH; Wilkinson D; KwaZulu Department of Health AIDS Programme, Amatikulu Centre,; Nyoni, South Africa.; Information from routine and sentinel surveillance was used to monitor the HIV/AIDS epidemic in KwaZulu-Natal, South Africa between 1991 and 1997. Comparisons were made between data obtained from (1) sentinel surveillance for antenatal HIV infection, pulmonary tuberculosis (PTB),
Chlamydia trachomatis infection in women with and without cervical intraepithelial neoplasia.: Int J STD AIDS. 1999 May;10(5):331-3. Unique Identifier : AIDSLINE MED/99288770; Takac I; Gorisek B; Gynecology and Perinatology Clinic, Maribor Teaching Hospital,; Slovenia. iztok.takac@sb-mb.si; The aim of the study was to compare the frequency of Chlamydia trachomatis infection in patients with cervical intraepithelial neoplasia (CIN) and in women without cervical pathology. In a study group of 423 patients with histologically proven CIN and in 108 controls with normal cervical smear, cytological material fo
A case of cat scratch disease masquerading as lymphogranuloma venereum.: Int J STD AIDS. 1999 May;10(5):334-5. Unique Identifier : AIDSLINE MED/99288771; Hagley M; Carne CA; Gorgees N; Clinic 1A, Addenbrooke's Hospital, Cambridge, UK.
Simultaneous occurrence of HTLV-I associated myelopathy, uveitis and smouldering adult T cell leukaemia. GIPH (Interdisciplinary HTLV-I/II Research Group).: Int J STD AIDS. 1999 May;10(5):336-7. Unique Identifier : AIDSLINE MED/99288772; Goncalves DU; Guedes AC; Carneiro-Proietti AB; Pinheiro SR; Catalan-Soares B; Proietti FA; Lambertucci JR; Department of Internal Medicine, Universidade Federal de Minas; Gerais, Brazil.
HIV/AIDS in Bangladesh: an assessment of biomedical risk factors for transmission.: Int J STD AIDS. 1999 May;10(5):338-46. Unique Identifier : AIDSLINE MED/99288773; Gibney L; Choudhury P; Khawaja Z; Sarker M; Islam N; Vermund SH; Schools of Public Health and Medicine, University of Alabama at; Birmingham, 35294-0022, USA. lgibney@uab.edu; Behavioural risk factors for HIV/AIDS in Bangladesh were reviewed in a preceding article in this journal. Omitted from that review was a discussion of potential biomedical risk factors including: (i) an unregulated blood supply system in which blood used in transfusions is not
Prevention of pelvic infection: room for improvement [letter]: Int J STD AIDS. 1999 May;10(5):351. Unique Identifier : AIDSLINE MED/99288774; Skinner CJ; Estcourt CS; Grant L; Forster GE
Outcome of inflammatory smears managed in a genitourinary medicine clinic [letter]: Int J STD AIDS. 1999 May;10(5):351-2. Unique Identifier : AIDSLINE MED/99288775; Harry TC
A self-consistent, microenvironment modulated screened coulomb potential approximation to calculate pH-dependent electrostatic effects in proteins.: Biophys J. 1999 Jul;77(1):3-22. Unique Identifier : AIDSLINE MED/99318716; Mehler EL; Guarnieri F; Department of Physiology and Biophysics, Mount Sinai School of; Medicine, CUNY, New York, New York 10029, USA.; mehler@inka.mssm.edu; An improved approach is presented for calculating pH-dependent electrostatic effects in proteins using sigmoidally screened Coulomb potentials (SCP). It is hypothesized that a key determinant of seemingly aberrant behavior in pKa shifts is due to the properties of the unique microenvironment around each residue. To he
HLA-derived peptides as novel immunomodulatory therapeutics.: J Am Soc Nephrol. 1999 Jun;10(6):1346-55. Unique Identifier : AIDSLINE MED/99288721; Murphy B; Krensky AM; Department of Medicine, Mount Sinai School of Medicine, New York,; New York, USA.; A growing body of experimental evidence demonstrates that synthetic peptides corresponding to linear sequences of MHC (HLA in humans) proteins have immunomodulatory effects in vitro and in vivo in animal models and in humans. Although the original concept was that these peptides inhibited antigen recognition at the MH
Rational optimization of a HIV-1 Tat inhibitor: rapid progress on combinatorial lead structures.: Biotechnol Bioeng. 1998-99;61(3):155-68. Unique Identifier : AIDSLINE MED/99328735; Klimkait T; Felder ER; Albrecht G; Hamy F; Institute for Medical Microbiology, University of Basel, Basel,; Switzerland.; Lead molecules identified by combinatorial chemistry approaches are preferred starting points for straightforward improvements of compound profiles. Structure-guided rationales can be supported and complemented by systematic variations based on the modular nature of the molecules. A peptoidic compound (CGP 64222), pre
The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.: Blood. 1999 Jul 15;94(2):663-72. Unique Identifier : AIDSLINE MED/99326318; Barillari G; Sgadari C; Fiorelli V; Samaniego F; Colombini S; Manzari V; Modesti A; Nair BC; Cafaro A; Sturzl M; Ensoli B; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi s sarcoma (KS) development in infected individuals. In this study, we investigated the molecular mechanisms responsible for the angiogenic effec
The relationship of personality dimensions in adult male rhesus macaques to progression of simian immunodeficiency virus disease.: Brain Behav Immun. 1999 Jun;13(2):138-54. Unique Identifier : AIDSLINE MED/99303528; Capitanio JP; Mendoza SP; Baroncelli S; California Regional Primate Research Center, University of; California, Davis, California 95616, USA.; Studies of nonhuman primate personality have suggested that physiological correlates of relevant behavioral dimensions exist. The present study examined personality using techniques similar to those employed in human personality research. Adult male rhesus monkeys were each rated on 25 adjectives while living in their
Differential immune system changes with acute and persistent stress for optimists vs pessimists.: Brain Behav Immun. 1999 Jun;13(2):155-74. Unique Identifier : AIDSLINE MED/99303529; Cohen F; Kearney KA; Zegans LS; Kemeny ME; Neuhaus JM; Stites DP; Department of Psychiatry, University of California, San; Francisco, USA.; This study investigated whether acute and persistent stressors and life change events were followed by changes in immune status, and whether dispositional optimism moderated these relationships. Thirty-nine healthy women ages 18-45 were followed prospectively for 3 months, with weekly assessment of acute and persisten
[Epidemiology of non-Hodgkin's lymphoma: recent data]: Bull Cancer. 1999 Jun;86(6):529-36. Unique Identifier : AIDSLINE MED/99348133; Chassagne-Clement C; Blay JY; Treilleux I; Sebban C; Bergeron C; Biron P; Philip T; Centre Leon-Berard, 28, rue Laennec, 69008 Lyon.; Non-Hodgkin s lymphoma consists of a group of disorders which is increasing for the last decades. In the USA, since the early 1970s, the incidence rate has increased by almost 60% and ranges from 3 to 4% per year, which is faster than for the majority of cancers. Important advances in our knowledge of histopathology t
Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy.: Int Arch Allergy Immunol. 1999 Jun;119(2):86-94. Unique Identifier : AIDSLINE MED/99323826; Haas H; Falcone FH; Holland MJ; Schramm G; Haisch K; Gibbs BF; Bufe A; Schlaak M; Forschungszentrum Borstel, Germany. hhaas@fz-borstel.de; The etiology of IgE-mediated allergies is complex and, thus far, not completely understood. A common feature, however, is the overproduction of IgE-inducing cytokines, e.g. interleukin-4(IL-4), compared to IgE-antagonistic cytokines, such as interferon-gamma or IL-12. IgE-inducing cytokines are produced by T helper ty
Doctors demand AIDS drugs for women who have been raped [news]: BMJ. 1999 Jun 5;318(7197):1507. Unique Identifier : AIDSLINE MED/99284564; Sidley P
Authors' words foster stigmatisation of commercial sex workers in India [letter; comment]: BMJ. 1999 Jun 5;318(7197):1559. Unique Identifier : AIDSLINE MED/99284605; Patnaik P; Gupta R; Lambert H
Prevention of vertical transmission of HIV: analysis of cost effectiveness of options available in South Africa.: BMJ. 1999 Jun 19;318(7199):1650-6. Unique Identifier : AIDSLINE MED/99301831; Soderlund N; Zwi K; Kinghorn A; Gray G; Centre for Health Policy, University of the Witwatersrand PO Box; 1038, Johannesburg 2000, South Africa. soderlun@icon.co.za; OBJECTIVE: To assess the cost effectiveness of vertical transmission prevention strategies by using a mathematical simulation model. DESIGN: A Markov chain model was used to simulate the cost effectiveness of four formula feeding strategies, three antiretroviral interventions, and combined formula feeding and antiretr
Universal HIV screening of pregnant women in England: cost effectiveness analysis.: BMJ. 1999 Jun 19;318(7199):1656-60. Unique Identifier : AIDSLINE MED/99301832; Postma MJ; Beck EJ; Mandalia S; Sherr L; Walters MD; Houweling H; Jager JC; National Institute of Public Health and the Environment, PO Box; 3720 BA Bilthoven, The Netherlands.; OBJECTIVE: To estimate the cost effectiveness of universal, voluntary HIV screening of pregnant women in England. DESIGN: Cost effectiveness analysis. Cost estimates of caring for HIV positive children were based on the stage of HIV infection and calculated using data obtained from a London hospital between 1986 and 1
Antenatal HIV testing: assessment of a routine voluntary approach.: BMJ. 1999 Jun 19;318(7199):1660-1. Unique Identifier : AIDSLINE MED/99301833; Simpson WM; Johnstone FD; Goldberg DJ; Gormley SM; Hart GJ; Department of Obstetrics and Gynaecology, Centre for Reproductive; Biology, University of Edinburgh, EH3 9EW.; wendy@lumsdenpark.freeserve.co.uk
Comparison of enzymatic activities of the HIV-1 and HFV integrases to their U5 LTR substrates.: Biochem Mol Biol Int. 1999 Apr;47(4):621-9. Unique Identifier : AIDSLINE MED/99252972; Oh YT; Shin CG; Department of Biotechnology, Chung-Ang University, Kyungki,; Korea.; The human immunodeficiency virus type 1 (HIV-1) and human foamy virus (HFV) integrase proteins were overexpressed in Escherichia coli, and purified to a near homogeneity by one- or two-step purification scheme. The endonucleolytic, integration, and disintegration activities for the HIV-1 and HFV integrases were charac
Multifactorial analysis of exchanger efficiency and liquid conservation during perfluorochemical liquid-assisted ventilation.: Biomed Instrum Technol. 1999 May-Jun;33(3):260-7. Unique Identifier : AIDSLINE MED/99288488; Wolfson MR; Miller TF; Peck G; Shaffer TH; Department of Physiology, Temple University School of Medicine,; Philadelphia, Pennsylvania 19140, USA.; marlar@astro.ocis.temple.edu; Liquid-assisted ventilation (LAV) of the lung with perfluorochemical (PFC) requires a method of oxygenating and removing CO2 from the liquid. Current PFC LAV techniques consist of total liquid ventilation, PFC lavage, and partial liquid ventilation. Because PFC liquid is volatile, it may be lost from the lung or venti
The paramyxovirus fusion protein forms an extremely stable core trimer: structural parallels to influenza virus haemagglutinin and HIV-1 gp41.: Mol Membr Biol. 1999 Jan-Mar;16(1):11-9. Unique Identifier : AIDSLINE MED/99265137; Lamb RA; Joshi SB; Dutch RE; Howard Hughes Medical Institute, Northwestern University,; Evanston, IL 60208-3500, USA.; The paramyxovirus fusion (F) protein mediates membrane fusion. The biologically active F protein consists of a membrane distal subunit F2 and a membrane anchored subunit F1. A highly stable structure has been identified comprised of peptides derived from the simian virus 5 (SV5) F1 heptad repeat A, which abuts the hyd
Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells.: Mol Membr Biol. 1999 Jan-Mar;16(1):111-8. Unique Identifier : AIDSLINE MED/99265149; Duzgunes N; Pretzer E; Simoes S; Slepushkin V; Konopka K; Flasher D; de Lima MC; Department of Microbiology, School of Dentistry, University of; the Pacific, San Francisco, CA 94115, USA. nduzgune@uop.edu; Intracellular delivery of novel macromolecular drugs against human immunodeficiency virus type-1 (HIV-1), including antisense oligodeoxynucleotides, ribozymes and therapeutic genes, may be achieved by encapsulation in or association with certain types of liposomes. Liposomes may also protect these drugs against nuclea
Structural basis for membrane fusion by enveloped viruses.: Mol Membr Biol. 1999 Jan-Mar;16(1):3-9. Unique Identifier : AIDSLINE MED/99265136; Weissenhorn W; Dessen A; Calder LJ; Harrison SC; Skehel JJ; Wiley DC; Laboratory of Molecular Medicine, Children's Hospital, Boston, MA; 02215, USA. weissen@embl-grenoble.fr; Enveloped viruses such as HIV-1, influenza virus, and Ebola virus express a surface glycoprotein that mediates both cell attachment and fusion of viral and cellular membranes. The membrane fusion process leads to the release of viral proteins and the RNA genome into the host cell, initiating an infectious cycle. This
HIV coreceptors, cell tropism and inhibition by chemokine receptor ligands.: Mol Membr Biol. 1999 Jan-Mar;16(1):49-55. Unique Identifier : AIDSLINE MED/99265141; Clapham PR; Reeves JD; Simmons G; Dejucq N; Hibbitts S; McKnight A; Section of Virology, Chester Beatty Laboratories, Institute of; Cancer Research, London, UK.; HIV is a persistent virus that survives and replicates despite an onslaught by the host s immune system. A strategy for cell entry, requiring the use of two receptors, has evolved that may help evade neutralizing antibodies. HIV and SIV usually require both CD4 and a seven transmembrane (7TM) coreceptor for infection.
HIV-1 envelope determinants for cell tropism and chemokine receptor use.: Mol Membr Biol. 1999 Jan-Mar;16(1):57-65. Unique Identifier : AIDSLINE MED/99265142; Hoffman TL; Doms RW; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.; Isolates of human immunodeficiency virus type-1 (HIV-1) display marked differences in their ability to replicate in macrophages and transformed T-cell lines in vitro, a property that has important implications for disease pathogenesis. The restriction in replication between these two CD4-positive cell types is largely
The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus.: Mol Membr Biol. 1999 Jan-Mar;16(1):67-72. Unique Identifier : AIDSLINE MED/99265143; Willett BJ; Hosie MJ; Department of Veterinary Pathology, University of Glasgow; Veterinary School, UK.; Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mec
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 May 28;9(22):199-200. Unique Identifier : AIDSLINE MED/99319380
[Ethical problems in nursing: recognition and professional conduct, as a nurse, regarding HIV infection of patients due to blood products]: Nihon Kango Kagakkaishi. 1997 Dec;17(4):69-75. Unique Identifier : AIDSLINE MED/99354831; Horii M; Takatani Y; Mori E; Andoh H; Ohta K; Okaya K; Katada N; Katsuta H; Kawamura S; Doi Y; Nakanishi M; Minami Y
Inhibition of endothelial receptor expression and of T-cell ligand activity by mycophenolate mofetil.: Transpl Immunol. 1998 Dec;6(4):251-9. Unique Identifier : AIDSLINE MED/99272167; Blaheta RA; Leckel K; Wittig B; Zenker D; Oppermann E; Harder S; Scholz M; Weber S; Schuldes H; Encke A; Markus BH; Department of General Surgery, Johann Wolfgang Goethe-University,; Frankfurt am Main, Germany. Blaheta@em.uni-frankfurt.de; The novel immunosuppressive drug mycophenolate mofetil (CellCept, MMF) blocks DNA-synthesis by the inhibition of the enzyme inosine monophosphate dehydrogenase (IMDH). IMDH is also involved in the synthesis of adhesion receptors which are known to play an important role in the regulation of cell-cell contacts. Therefo
The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentans.: Unique Identifier : AIDSLINE MED/99280355; Yirmiya R; Weidenfeld J; Barak O; Avitsur R; Pollak Y; Gallily R; Wohlman A; Ovadia H; Ben-Hur T; Intracerebral administration of Mycoplasma fermentans (MF), a small microorganism that has been found in the brain of some AIDS patients, induces behavioral and neuroendocrine alterations in rats. To examine the role of tumor necrosis factor-alpha (TNFalpha) and interleukin-1 (IL-1) in mediating these effects we measu
Differences and similarities between chronic obstructive pulmonary disease and asthma.: Unique Identifier : AIDSLINE MED/99352270; Jeffery PK; Asthma and chronic obstructive pulmonary disease (COPD) are complex conditions with imprecise definitions, which make definitive morphological comparisons difficult. The airways in asthma are occluded by tenacious plugs of exudate and mucus, and there is fragility of airway surface epithelium, thickening of the reticu
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.: Clin Exp Allergy. 1999 Jun;29 Suppl 2:33-6. Unique Identifier : AIDSLINE MED/99352272; Kapsenberg ML; Hilkens CM; Wierenga EA; Kalinski P; Department of Cell Biology and Histology, Academic Medical Center; of the University of Amsterdam, Amsterdam, The Netherlands.; Optimal clearance of the various pathogen types encountered by the human body requires the selective activation of particular cellular and/or humoral immune responses. The orchestration of the types of effector responses is directed by Th cells through the production of type 1 (Th1 cell-associated) and type 2 (Th2 cel
Development of T-cell memory against inhalant allergens: risks for the future.: Clin Exp Allergy. 1999 Jun;29 Suppl 2:8-13. Unique Identifier : AIDSLINE MED/99352269; Holt PG; Department of Cell Biology, TVW Telethon Institute for Child; Health Research, West Perth, Australia.; Recent evidence suggests that the development of chronic allergic respiratory disease is a biphasic process. Phase 1 commonly occurs during early childhood and in many instances appears to be initiated in utero. This involves initial priming of the Th-cell system against ubiquitous environmental allergens, and subsequ
Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses.: Unique Identifier : AIDSLINE MED/99330957; Slattery JP; Franchini G
[Infectious esophagitis]: Gastroenterol Hepatol. 1999 Jun-Jul;22(6):302-8. Unique Identifier : AIDSLINE MED/99338640; Arenas Mirave JI; Montalvo Ollobarren II; Gil Lasa I; Servicio de Aparato Digestivo, Hospital Aranzazu, San; Sebastian.
IMGT, the international ImMunoGeneTics database: a new design for immunogenetics data access.: Medinfo. 1998;9 Pt 1:351-5. Unique Identifier : AIDSLINE MED/99312470; Giudicelli V; Chaume D; Mennessier G; Althaus HH; Muller W; Bodmer J; Malik A; Lefranc MP; Laboratoire d'ImmunoGenetique Moleculaire, LIGM, UMR 5535; (CNRS, Universite Montpellier II), France.; IMGT, the international ImMunoGeneTics database is an integrated database specializing in Immunoglobulins (Ig), T-cell receptors (TcR) and MHC molecules of all vertebrate species, created by Marie-Paule Lefranc, University of Montpellier, CNRS, Montpellier, France (Nucleic Acids Re
Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A.: Chung Hua I Hsueh Tsa Chih (Taipei). 1999 Jul;62(7):450-4. Unique Identifier : AIDSLINE MED/99346734; Hsu HC; Chen YF; Ho CH; Department of Medicine, Veterans General Hospital-Taipei, Taiwan,; ROC.; BACKGROUND: Plasma-derived factor VIII concentrates used in the treatment of hemophilia A have the potential danger of transfusion-associated viral disease. The safety and efficacy of a recombinant factor VIII preparation for the treatment of this disorder were evaluated in this study. METHODS: We compared the pharmac
Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate.: Unique Identifier : AIDSLINE MED/99328843; Doniger J; Muralidhar S; Rosenthal LJ; Department of Microbiology and Immunology, Georgetown University; Medical Center, Washington, D.C. 20007, USA.; This review is an update on the transforming genes of human cytomegalovirus (HCMV) and human herpesvirus 6 (HHV-6). Both viruses have been implicated in the etiology of several human cancers. In particular, HCMV has been associated with cervical carcinoma and adenocarcinomas of the
Trait-like immunological and hematological measures in female rhesus across varied environmental conditions.: Am J Primatol. 1999;48(3):197-223. Unique Identifier : AIDSLINE MED/99308702; Lilly AA; Mehlman PT; Higley JD; Dept. of Anthropology, SUNY, Stony Brook, New York, USA.; In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and h
Mycobacterium avium interaction with macrophages and intestinal epithelial cells.: Front Biosci. 1999 Jul 15;4:D582-8. Unique Identifier : AIDSLINE MED/99348569; Sangari FJ; Parker A; Bermudez LE; Kuzell Institute for Arthritis & Infectious Diseases, California; Pacific Medical Center Research Institute, 2200 Webster Street,; Suite 305, San Francisco, CA 94115, USA.; Mycobacterium avium is an environmental microorganism that is adapted to live both in the environment (mainly in water and soil) and in bird, fish and mammal hosts. In humans, M. avium infection is seen in patients with some sort of immunosuppression, such as patients with chronic lung disease, and Acquired Immunodefi
Immunological and molecular characterization of an aggressive murine lymphoma variant: modulation in vitro and in vivo.: Int J Oncol. 1999 Jul;15(1):71-9. Unique Identifier : AIDSLINE MED/99307655; Jurianz K; von Hoegen P; Schirrmacher V; Division of Cellular Immunology, German Cancer Research Center,; D-69120 Heidelberg, Germany.; The highly metastatic murine ESb-L lymphoma was analyzed with respect to its possible origin and phenotype modulation. By determining the methylation status of the CD8 gene an early thymic origin of the ESb-L lymphoma cells is suggested. It revealed that the precursors of ESb-L cells had at least one CD8 allele expres
MAC prophylaxis in the era of polypharmacy.: WMJ. 1999 May-Jun;98(3):46-8. Unique Identifier : AIDSLINE MED/99342624; Sawhney N; Infectious Disease Consultants of Wisconsin, Milwaukee 53215,; USA.; In the advanced stages of AIDS, patients are increasingly susceptible to disseminated Mycobacterium avium-intracellulare (MAC) infection, causing significant morbidity and mortality. It has been shown that prophylaxis against this infection is effective in reducing the incidence as well as the symptoms of MAC. Althoug
Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes.: Chem Biol Interact. 1999 Jun 1;121(1):37-48. Unique Identifier : AIDSLINE MED/99345337; Reinach B; de Sousa G; Dostert P; Ings R; Gugenheim J; Rahmani R; Pharmacia and Upjohn, Drug Metabolism Research, Nerviano, Italy.; The aim of this study was to evaluate rifabutin (RBT) and rifampicin (RIF) capabilities in inducing various xenobiotic metabolizing enzymes such as cytochromes P450 (CYPs) and UDP-glucuronosyl-transferases (UGTs) in cultured fresh and cryopreserved human hepatocytes. Enzyme induction was assessed through the use of se
Are HIV lookbacks worthwhile? Outcome of an exercise to notify patients treated by an HIV infected health care worker. Incident Management Teams [see comments]: Commun Dis Public Health. 1999 Jun;2(2):126-9. Unique Identifier : AIDSLINE MED/99331159; Donnelly M; Duckworth G; Nelson S; Wehner H; Gill N; Nazareth B; Cummins A; PHLS Communicable Disease Surveillance Centre, Thames.; This report describes the management and outcome of one of the largest exercises undertaken in the United Kingdom to notify patients exposed to an HIV infected health care worker. Eighty-six per cent (1597/1852) of patients on whom the infected junior doctor in obstetrics and gynaecolo
Lookback in angst [editorial; comment]: Commun Dis Public Health. 1999 Jun;2(2):79-81. Unique Identifier : AIDSLINE MED/99331149; Weller I
The global impact of HIV infection and disease.: Commun Dis Public Health. 1999 Jun;2(2):85-95. Unique Identifier : AIDSLINE MED/99331152; Nicoll A; Gill ON; HIV and STD Division, PHLS Communicable Disease Surveillance; Centre, London. anicoll@phls.co.uk; Patterns of HIV infection and disease are changing. HIV will soon enter the top five causes of death worldwide and is now believed to cause more deaths than malaria. Commonwealth countries account for around 60% of prevalent HIV infections worldwide. Around half of all global HIV transmissions are to people under 25 y
Primary T-cell and activated macrophage response associated with tumor protection using peptide/poly-N-acetyl glucosamine vaccination.: Clin Cancer Res. 1999 May;5(5):1173-82. Unique Identifier : AIDSLINE MED/99280221; Maitre N; Brown JM; Demcheva M; Kelley JR; Lockett MA; Vournakis J; Cole DJ; Department of Surgery, Medical University of South Carolina,; Charleston 29425, USA.; The mode of peptide-based cancer vaccine administration critically affects the ability to achieve a clinically relevant tumor-specific response. We have previously shown (Cole et al., Clin. Cancer Res., 3: 867-873, 1997) that a specific formulation of the polysaccharide poly-N-acetyl glucosamine (p-GlcNAc, designated
Sexuality and sex education at home and school.: Adolesc Med. 1999 Jun;10(2):195-209, v. Unique Identifier : AIDSLINE MED/99298842; Kirby D; Department of Research, ETR Associates, Santa Cruz, California; 95061-1830, USA.; This article reviews numerous studies of parent-adolescent communication about sexuality and 30 studies of sexuality and HIV education programs. Although parent-adolescent communication about sexuality has increased during the last few decades, both the occurrence and the quality of this communication could still be g
Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases.: Bioorg Med Chem Lett. 1999 Apr 19;9(8):1179-84. Unique Identifier : AIDSLINE MED/99258861; Kurihara S; Tsumuraya T; Fujii I; Biomolecular Engineering Research Institute, Suita, Osaka, Japan.; Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.
Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.: Int J Mol Med. 1999 Jun;3(6):633-7. Unique Identifier : AIDSLINE MED/99274687; Sales ME; Espanol AJ; Sterin-Borda L; Borda E; de Bracco MM; Instituto de Oncologia Angel H. Roffo, Buenos Aires, Argentina.; In this work we demostrate that IgA purified from HIV infected patients recognizes a band with a molecular weight corresponding to radiolabelled ileal muscarinic acethylcholine receptors (mAChR) by immunoblotting. HIV+-IgA triggers the signals that are the consequence of mAChR stimulation in the intestine, regulating
Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation.: Clin Immunol. 1999 Jul;92(1):103-10. Unique Identifier : AIDSLINE MED/99343956; Di Marzio L; Moretti S; D'Alo S; Zazzeroni F; Marcellini S; Smacchia C; Alesse E; Cifone MG; De Simone C; Department of Experimental Medicine, University of L'Aquila,; L'Aquila, Italy.; The aim of this study was to investigate the impact of long-term acetyl-L-carnitine administration on CD4 and CD8 absolute counts, apoptosis, and insulin-like growth factor-1 (IGF-1) serum levels in HIV-1-infected subjects. The generation of cell-associated ceramide and HIV-1 viremia were also investigated. Eleven asy
Enhanced IFN-gamma production in vitro by CD8+ T cells in hemophiliacs with AIDS as demonstrated on the single-cell level.: Clin Immunol. 1999 Jul;92(1):111-7. Unique Identifier : AIDSLINE MED/99343957; Pae Y; Minagawa H; Hayashi J; Kashiwagi S; Yanagi Y; Faculty of Medicine, Kyushu University, Fukuoka, Japan.; We examined T cells from HIV-infected hemophiliacs under antiviral therapy, on the single-cell level, for cytokine production in vitro in response to stimulation. The percentage of IL-2-producing cells was markedly decreased among both CD3+CD8- and CD3+CD8+ cells, while the proportion of IFN-gamma-producing cells was
Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells [see comments]: Clin Immunol. 1999 Jul;92(1):14-24. Unique Identifier : AIDSLINE MED/99343947; Kaushal S; Landay AL; Lederman MM; Connick E; Spritzler J; Kuritzkes DR; Kessler H; Levine BL; St. Louis DC; June CH; Henry M. Jackson Foundation for the Advancement of Military; Medicine, U.S. Military HIV Research Program, Bethesda, Maryland; 20889, USA.; Changes in mean telomeric terminal restriction fragment (TRF) length were examined as a marker for cellular replicative history in HIV-1-infected individuals after institution of anti-retroviral therapy (ART). Increases in mean T cell TRF lengths were observed in most patients following therapy; however, the contribut
Primary HIV infection of infants: the effects of somatic growth on lymphocyte and virus dynamics [see comments]: Clin Immunol. 1999 Jul;92(1):25-33. Unique Identifier : AIDSLINE MED/99343948; Krogstad P; Uittenbogaart CH; Dickover R; Bryson YJ; Plaeger S; Garfinkel A; Jonsson Comprehensive Cancer Center, University of California,; Los Angeles, California 90095-5217, USA.; Acute HIV infection is characterized by the appearance of high concentrations of virus in the peripheral blood. In adults, this high-level viremia spontaneously abates after several weeks. In contrast, after perinatal infection of infants, blood virus levels remain high for many months, during which the concentration
HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool [editorial; comment]: Clin Immunol. 1999 Jul;92(1):3-5. Unique Identifier : AIDSLINE MED/99343945; Haynes BF
Interferon-gamma therapy reduces blood leukocyte levels in patients with atopic dermatitis: correlation with clinical improvement.: Clin Immunol. 1999 Jul;92(1):49-55. Unique Identifier : AIDSLINE MED/99343950; Ellis CN; Stevens SR; Blok BK; Taylor RS; Cooper KD; Department of Dermatology, University of Michigan Medical School; and Veterans Affairs Medical Center, Ann Arbor, Michigan 48109,; USA.; Atopic dermatitis (AD) is a chronic inflammatory skin disease with abnormalities of both cellular and humoral immunity. Subcutaneous recombinant human interferon-gamma (IFN-gamma) provides therapeutic benefit to AD patients. In contrast to expectations, IFN-gamma does not cause a decrease in the elevated levels of cir
Chagas' disease encephalitis: intense CD8+ lymphocytic infiltrate is restricted to the acute phase, but is not related to the presence of Trypanosoma cruzi antigens.: Clin Immunol. 1999 Jul;92(1):56-66. Unique Identifier : AIDSLINE MED/99343951; Silva AA; Roff; Marino AP; dos Santos PV; Quirico-Santos T; Paiva CN; Lannes-Vieira J; Department of Immunology, Oswaldo Cruz Institute-Fiocruz, Rio de; Janeiro, Rio de Janeiro, 21045-900, Brazil.; Central nervous system (CNS) damage can occur during Chagas disease, especially in children and immunosuppressed patients. During the acute phase, amastigotes are rarely found, but inflammatory infiltrates are scattered throughout the CNS. Moreover, peripheral lymphocytes and antibodies recognizing neural components
Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity.: Clin Immunol. 1999 Jul;92(1):90-6. Unique Identifier : AIDSLINE MED/99343954; Xin KQ; Lu Y; Hamajima K; Fukushima J; Yang J; Inamura K; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, 236, Japan.; Cytokines play important roles in regulating immune response. This study evaluated the adjuvant effect of an expression plasmid encoding RANTES (regulated on activation normal T-cell expressed and secreted) chemokine on the immunity induced by a DNA vaccine. This vaccine consists of expression plasmids encoding the en
Unusual neurological manifestations of primary human immunodeficiency virus infection.: Eur J Neurol. 1998 Jul;5(4):369-73. Unique Identifier : AIDSLINE MED/99338343; Hassin-Baer S; Steiner I; Achiron A; Sadeh M; Vonsover A; Hassin D; Department of Neurology, Chaim Sheba Medical Center,; Tel-Hashomer, Israel.; The nervous system may be involved during primary human immunodeficiency virus (HIV) infection. Recognized clinical syndromes include meningitis, meningo-encephalitis, myelopathy, polyneuropathy and rhabdomyolysis. We report three patients with unusual neurological presentations of primary HIV infection: intracranial
The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients.: Mol Diagn. 1999 Mar;4(1):37-43. Unique Identifier : AIDSLINE MED/99248376; Burke DG; Leonard DG; Imperiale TF; Valdez H; Karaman B; Shick E; Kalayjian RC; Departments of Medicine, Pathology and Radiology, University; Hospitals of Cleveland, MetroHealth Medical Center, Cleveland, OH; 44109-1998, USA.; BACKGROUND: Polymerase chain reaction (PCR) assays of cerebrospinal fluid (CSF) for cytomegalovirus ( CMV ) DNA have facilitated the diagnosis of CMV-associated central nervous system disease in AIDS patients. We attempt to cor
The re-use of irrigating equipment for flexible cystoscopy is not safe.: BJU Int. 1999 Jun;83(9):948-53. Unique Identifier : AIDSLINE MED/99296783; Molina-Navarro C; Bhatia BS; Awogu O; Ochai J; Jones MA; Department of General Surgery, Royal Bournemouth Hospital,; Bournemouth, UK.; OBJECTIVE: To determine the incidence of fluid reflux from the lower urinary tract into the connecting tubing used for irrigation in patients undergoing flexible cystoscopy. PATIENTS AND METHODS: The study was conducted in 94 consecutive male and female patients attending routine outpatient flexible cystoscopy lists.
Advances in the diagnosis and treatment of human papillomavirus infections.: Clin Obstet Gynecol. 1999 Jun;42(2):206-20. Unique Identifier : AIDSLINE MED/99298980; Sedlacek TV; Allegheny University, Philadelphia, PA 19146, USA.; During the past decade, much has been learned about the natural history of HPV. Most infections occur early in one s sexual life. The overwhelming majority of infections are cleared by the host immune system and never present as warts or neoplasia. Certain patient behavior such as smoking, frequent sex with many diffe
Data and safety monitoring in the Concorde and Alpha trials.: Control Clin Trials. 1999 Jun;20(3):207-28. Unique Identifier : AIDSLINE MED/99284387; Armitage P; St Peter's College, Oxford, United Kingdom.; Concorde was a randomized trial to compare immediate and deferred zidovudine ( AZT ) treatment for persons with asymptomatic HIV infection. Alpha was a randomized trial to compare the efficacy of two doses of didanosine (ddI), in persons with symptomati
Data and safety monitoring in the Delta trial.: Unique Identifier : AIDSLINE MED/99284388; Armitage P; St. Peter's College, Oxford, United Kingdom.; Delta was a randomized trial designed to test whether combinations of zidovudine ( AZT ) with didanosine (ddI) or zalcitabine ( ddC ) were more effective than AZT alone for HIV-infected p
Relationship between event rates and treatment effects in clinical site differences within multicenter trials: an example from primary Pneumocystis carinii prophylaxis.: Control Clin Trials. 1999 Jun;20(3):253-66. Unique Identifier : AIDSLINE MED/99284390; Ioannidis JP; Dixon DO; McIntosh M; Albert JM; Bozzette SA; Schnittman SM; HIV Research Branch, Division of AIDS, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland, USA.; The results of multicenter clinical trials may differ across participating clinical sites. We present a diagnostic approach for evaluating this diversity that emphasizes the relationship between the observed event rates and treatment effects. We use as an example a trial of sequential strategies of Pneumocystis prophy
Acquired immunodeficiency syndrome, Pneumocystis carinii pneumonia, and the danger of prognostication: apples to apples [editorial; comment]: Crit Care Med. 1999 Jun;27(6):1043-4. Unique Identifier : AIDSLINE MED/99323323; Peruzzi WT
Pneumocystis carinii pneumonia requiring intensive care management: survival and prognostic study in 110 patients with human immunodeficiency virus [see comments]: Crit Care Med. 1999 Jun;27(6):1109-15. Unique Identifier : AIDSLINE MED/99323343; Bedos JP; Dumoulin JL; Gachot B; Veber B; Wolff M; Regnier B; Chevret S; Service de Reanimation des Maladies Infectieuses, Groupe; Hospitalier Bichat-Claude Bernard, Paris, France.; OBJECTIVE: To perform a descriptive study of patients with acute respiratory failure secondary to acquired immunodeficiency syndrome-related Pneumocystis carinii pneumonia and to identify variables that are predictive of death within 3 months. DESIGN: Case series study. SETTING: Infectious disease intensive care unit
Establishment of T-helper type 2 clone-induced eosinophilia in mouse conjunctiva.: Exp Eye Res. 1999 Jul;69(1):69-74. Unique Identifier : AIDSLINE MED/99307112; Hamada M; Sawa K; Nakata K; Ophthalmic Research Division, Santen Pharmaceutical Co., Ltd.,; 8916-16 Takayama-cho, Ikoma-shi, 630-0101, Japan.; Eosinophil infiltration is one of the aspects of the inflammatory response to an allergen. The aim of this study was to establish T-helper type-2 (Th2)-induced conjunctival eosinophilia in mice to evaluate the effect of anti-allergic drugs. Th2 clone, D10.G4.1. (D10) with its specific antigen, conalbumin was co-inject
Kaposi's sarcoma associated with Castleman's disease [letter]: Eur J Haematol. 1999 Jul;63(1):67-70. Unique Identifier : AIDSLINE MED/99341408; Zeidman A; Fradin Z; Cohen AM; Mittelman M
New substrates of DNA polymerases.: FEBS Lett. 1999 Jun 18;453(1-2):6-10. Unique Identifier : AIDSLINE MED/99330158; Victorova L; Sosunov V; Skoblov A; Shipytsin A; Krayevsky A; Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, Moscow.; Bis-(2 -deoxynucleoside) 5 ,5 -tetraphosphates and bis-(2 -deoxynucleoside) 5 ,5 -triphosphates were shown to be a new type of substrate for several DNA polymerases of human, bacterial and viral origin. Their substrate properties depend both on their structure and on the nature of the enzyme. They are incorporated by
Partial nucleotide sequencing of the NS3/helicase region of hepatitis G virus to prove vertical transmission.: FEMS Microbiol Lett. 1999 Jun 15;175(2):273-9. Unique Identifier : AIDSLINE MED/99314157; Takayama S; Miura T; Tominaga T; Taki M; Matsuo S; Sugii S; Shimotohno K; Division of Laboratory Research, St. Marianna University; Yokohamashi Seibu Hospital, Kanagawa, Japan.; stakayam@mb.kcom.ne.jp; To study non-parental transmission of hepatitis G virus and/or GB virus C (HGV/GBV-C), we sequenced and compared the NS3/helicase region of the virus for five HGV/GBV-C RNA-positive mothers and their 11 children who had experienced neither blood transfusion nor overt hepatitis and were negative for HBV, HCV and HIV, e
Anti-P30-52 monoclonal antibody cross-reacted to Env V3 and inhibited the viral multiplication of HIV-1-infected MT-4 cells.: Hybridoma. 1999 Apr;18(2):139-47. Unique Identifier : AIDSLINE MED/99306681; Ota A; Bautista AN; Yadav ML; Ueda S; Department of Neurovirology, Research Institute for Microbial; Diseases, Osaka University, Suita City, Japan.; It is well known that the anti-p17 antibody titer decreases with the disease progression among human immunodeficiency virus type 1 (HIV-1) carriers. We previously established several murine anti-p17 monoclonal antibodies (MAbs) to investigate the immunological role of p17, and to further characterize these MAbs, we ex
Cross-reactivity of anti-HIV-1-p17-derivative peptide (P30-52) antibody to Env V3 peptide.: Hybridoma. 1999 Apr;18(2):149-57. Unique Identifier : AIDSLINE MED/99306682; Ota A; Tanaka-Taya K; Ueda S; Department of Neurovirology, Research Institute for Microbial; Diseases, Osaka University, Suita City, Japan.; Strong antibody responses are often seen in human immunodeficiency virus type 1 (HIV-1) carriers, but it is not known whether these antibodies are effective in the inhibition of disease progression. In this study, we examined antigenic epitopes for anti-HIV-1 p17 antibody (p17 Ab) in an HIV-1 carrier s serum, and foun
B lymphocytes in lymph nodes and peripheral blood are important for binding immune complexes containing HIV-1.: Immunology. 1999 Apr;96(4):612-9. Unique Identifier : AIDSLINE MED/99250346; Jakubik JJ; Saifuddin M; Takefman DM; Spear GT; Department of Immunology and Microbiology, Rush University, 1653; W. Congress Parkway, Chicago, IL. 60612, USA.; We investigated the interaction of HIV immune complexes (HIV IC) with mononuclear cells from lymph nodes and blood. While antibody alone did not affect binding of HIV IC to mononuclear cells, antibody plus complement increased binding by as much as 10-fold and complement alone also increased binding slightly. Most of
Antigen-specific B and T cells in human/mouse radiation chimera following immunization in vivo.: Immunology. 1999 Apr;96(4):634-41. Unique Identifier : AIDSLINE MED/99250349; Bocher WO; Marcus H; Shakarchy R; Dekel B; Shouval D; Galun E; Reisner Y; Department of Immunology, The Weizmann Institute of Science,; Rehovot, Israel.; Adoptive transfer of human peripheral blood mononuclear cells (PBMC) into mice with severe combined immunodeficiency (SCID) or into lethally irradiated BALB/c mice radioprotected with SCID bone marrow, leads to marked engraftment of human T and B cells. In such chimeras, human serum antibody responses can be stimulate
The role of IL-12 in the control of MCMV is fundamentally different in mice with a retroviral immunodeficiency syndrome (MAIDS).: Unique Identifier : AIDSLINE MED/99250807; Peacock CD; Price P; The present study investigates the susceptibility of C57BL mice exhibiting T cell immunodeficiency and lymphadenopathy induced by LP-BM5 murine leukaemia virus (MAIDS) to murine cytomegalovirus (MCMV). Treatment of normal (M-) mice with anti-IL-12 increased the contribution of IgG1
Dr. P. C. Sen Memorial Award Paper. A study of HIV infection in thalassaemia patients of rural Bengal.: Indian J Public Health. 1998 Jul-Sep;42(3):81-7. Unique Identifier : AIDSLINE MED/99317749; Sur D; Chakraborty AK; Mukhopadhyay SP; Thalassaemia patients receiving repeated blood transfusions are vulnerable to transfusion related infections. HIV infection is the most life threatening of them all. Blood being the most efficient mode of transmission of HIV, increases the risk of infection even further. Although the National AIDS Control programme ha
Mucocutaneous manifestations of HIV infection: a retrospective analysis of 145 cases in a Chinese population in Malaysia.: Int J Dermatol. 1999 Jun;38(6):457-63. Unique Identifier : AIDSLINE MED/99323716; Jing W; Ismail R; Department of Medicine, University of Malaya, Kuala Lumpur,; Malaysia.; BACKGROUND: Mucocutaneous lesions directly related to human immunodeficiency virus (HIV) infection usually present as initial manifestations of immune deficiency. The most common mucocutaneous lesions are Kaposi s sarcoma, histoplasmosis, oro-esophageal candidiasis, oral hairy leukoplakia, and, in Asia, Penicillium ma
[High viral content in men's semen during highly active antiretroviral therapy]: Hautarzt. 1999 Apr;50(4):317. Unique Identifier : AIDSLINE MED/99283358
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer.: J Biol Chem. 1999 Jul 9;274(28):19885-93. Unique Identifier : AIDSLINE MED/99321920; Powell MD; Beard WA; Bebenek K; Howard KJ; Le Grice SF; Darden TA; Kunkel TA; Wilson SH; Levin JG; Laboratory of Molecular Genetics, NICHD, National Institutes of; Health, Bethesda, Maryland 20892, USA.; During retrovirus replication, reverse transcriptase (RT) must specifically interact with the polypurine tract (PPT) to generate and subsequently remove the RNA primer for plus-strand DNA synthesis. We have investigated the role that human immunodeficiency virus-1 RT residues in the alphaH and alphaI helices in the th
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.: J Cell Biol. 1999 Jun 28;145(7):1471-82. Unique Identifier : AIDSLINE GENBANK/AJ242778; Heyninck K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R; Department of Molecular Biology, Flanders Interuniversity; Institute for Biotechnology, University of Ghent, B-9000 Ghent,; Belgium.; The zinc finger protein A20 is a tumor necrosis factor (TNF)- and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression. However, the molecular mechanism by which A20 exerts this effect is still unclear. We show that A20 does not inhibit TNF- indu
Fatal herpetic hepatitis in adult following short corticotherapy: a case report.: Intensive Care Med. 1999 Apr;25(4):415-7. Unique Identifier : AIDSLINE MED/99271947; Seksik P; Gozlan J; Guitton C; Galula G; Maury E; Offenstadt G; Medical Intensive Care Unit, Hopital Saint-Antoine, Assistance; Publique-Hopitaux de Paris, France.; Herpes simplex virus hepatitis (HSV hepatitis) is an uncommon and severe complication of HSV type 1 and HSV type 2 infection. HSV hepatitis affects mostly immunocompromised patients. We report the case of a young man without any previous known immunodeficiency who developed fatal HSV hepatitis in the first 8 days of o
Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity.: J Allergy Clin Immunol. 1999 Jul;104(1):163-8. Unique Identifier : AIDSLINE MED/99328936; Shimada Y; Sato S; Hasegawa M; Tedder TF; Takehara K; Department of Dermatology, Kanazawa University School of; Medicine, Kanazawa, Japan.; BACKGROUND: L-selectin mediates leukocyte rolling on endothelium at sites of inflammation, suggesting that L-selectin may be involved in the development of cutaneous lesions of atopic dermatitis (AD). After leukocyte activation, L-selectin is rapidly shed from the cell surface. OBJECTIVE: The purpose of this study was
Adoptively transferred late allergic response is inhibited by IL-4, but not IL-5, antisense oligonucleotide.: J Allergy Clin Immunol. 1999 Jul;104(1):205-14. Unique Identifier : AIDSLINE MED/99328945; Molet S; Ramos-Barbon D; Martin JG; Hamid Q; Meakins-Christie Laboratories, McGill University, Montreal,; Quebec, Canada.; BACKGROUND: We have shown previously that the late airways response (LAR) can be transferred by ovalbumin-primed CD4(+) T lymphocytes in Brown Norway rats. This response is associated with an increase of eosinophils and high expression of TH2 cytokines (IL-4 and IL-5) in bronchoalv
Eosinophil involvement and serum IgE level in HIV-1-infected children.: J Allergy Clin Immunol. 1999 Jul;104(1):245-7. Unique Identifier : AIDSLINE MED/99328954; Onorato J; Esposito S; Scovena E; Morandi B; Morelli M; Pizzi M; Zisa G; Marchisio P; Principi N; Paediatric Department IV, University of Milan, L. Sacco Hospital,; Milan, Italy.
Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigens.: J Allergy Clin Immunol. 1999 Jul;104(1):37-45. Unique Identifier : AIDSLINE MED/99328919; Hauk PJ; Wenzel SE; Trumble AE; Szefler SJ; Leung DY; Divisions of Allergy-Immunology, National Jewish Medical and; Research Center, Denver, CO, USA.; BACKGROUND: T cells are thought to play an important role in the pathogenesis of chronic asthma. The immunologic triggers that contribute to poorly controlled asthma are unknown but may include infectious agents. Superantigens (SAgs), which stimulate T cells expressing selected T-cell receptor (TCR) beta-chain variabl
Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers.: Infect Control Hosp Epidemiol. 1999 Jun;20(6):428-30. Unique Identifier : AIDSLINE MED/99321070; D'Amico R; Pinto LA; Meyer P; Landay AL; Harris AA; Clerici M; Berzofsky JA; Shearer GM; Kessler HA; Department of Medicine, Rush Medical College, Chicago, Illinois,; USA.; We evaluated the effects of zidovudine postexposure prophylaxis (PEP) on the development of human immunodeficiency virus (HIV) envelope-specific cytotoxic T-lymphocyte responses in 20 healthcare workers with occupational exposures to HIV. Seven healthcare workers were treated with zidovudine PEP. Only 1 of 7 treated,
Occupational exposure and voluntary human immunodeficiency virus testing: a survey of Maryland hospitals.: Infect Control Hosp Epidemiol. 1999 Jun;20(6):430-2. Unique Identifier : AIDSLINE MED/99321071; Solomon L; Thompson C; Squiers L; Wulff K; Benjamin G; Department of Health and Mental Hygiene, AIDS Administration,; Baltimore, Maryland 21202, USA.; A survey was conducted to estimate how often healthcare providers were exposed to patients blood and the percentage of incidents in which patients agreed to human immunodeficiency virus (HIV) testing. Data from 38 hospitals with 53,508 employees revealed 2,244 exposures. Of 1,732 requests for information regarding th
Nurses failure to appreciate the risks of infection due to needle stick accidents: a hospital based survey.: J Hosp Infect. 1999 May;42(1):53-9. Unique Identifier : AIDSLINE MED/99291390; Leliopoulou C; Waterman H; Chakrabarty S; Royal Free Hospital Medical School, London.; One of the most important occupational risks to healthcare workers is exposure is to blood-borne viruses. This study examined nurses perceptions of risk of contracting infection following single or multiple exposure to blood or body fluids. Two hundred and ninety nurses were surveyed using a questionnaire. One hundre
A two-type model for the Cuban national programme on HIV/AIDS.: IMA J Math Appl Med Biol. 1999 Jun;16(2):143-54. Unique Identifier : AIDSLINE MED/99327509; Lounes R; de Arazoza H; Universite Paris V, Laboratoire de Statistique Medicale, UA; CNRS 1323, France.; We study deterministic and stochastic versions of a birth and death process for a two-type population with immigration for both types. For the stochastic model we consider the case where the rates are time dependent, and also when they are constant, as is the case in our AIDS application. We derive the probability gen
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas.: J Endod. 1999 Apr;25(4):239-42. Unique Identifier : AIDSLINE MED/99354679; Hren NI; Gubina M; Ihan A; Clinic for Maxillofacial and Oral Surgery, University Clinical; Centre Ljubljiana, Slovenia.; Seventeen dental periapical lesions were investigated to study bacterial colonization. Periapical lesions, obtained after apicotomy, were also enzymatically desegregated to quantitatively analyze lymphocyte subpopulations by flow cytometry. Fourteen samples yielded a positive bacterial growth when homogenized and cult
Elective cesarean delivery to prevent vertical transmission of HIV.: J Fam Pract. 1999 Jul;48(7):493-4. Unique Identifier : AIDSLINE MED/99355193; DuBard CA; Newton WP; University of North Carolina, Chapel Hill, USA.
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity.: J Med Chem. 1999 Jul 15;42(14):2561-8. Unique Identifier : AIDSLINE MED/99340126; Cirrincione G; Almerico AM; Barraja P; Diana P; Lauria A; Passannanti A; Musiu C; Pani A; Murtas P; Minnei C; Marongiu ME; La Colla P; Istituto Farmacochimico, Universita degli Studi, Via Archirafi; 32, 90123 Palermo, Italy.; Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization of substituted 2-(2-aminophenyl)indoles followed by an intramolecular coupling reaction of the diazonium group with the indole nitrogen. To obtain the indolobenzotriazine system it was necessary to protect the 3 po
Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.: J Med Chem. 1999 Jul 15;42(14):2662-72. Unique Identifier : AIDSLINE MED/99340136; Xie L; Takeuchi Y; Cosentino LM; Lee KH; Natural Products Laboratory, Division of Medicinal Chemistry and; Natural Products, School of Pharmacy, University of North; Carolina, Chapel Hill, North Carolina 27599, USA.; To explore the structural requirements of (+)-cis-khellactone derivatives as novel anti-HIV agents, 24 monosubstituted 3 , 4 -di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives were synthesized asymmetrically. These compounds included 4 isomeric monomethoxy analogues (3-6), 4 isomeric monomethyl analogues (7-10
Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events.: J Mol Biol. 1999 Jul 2;290(1):21-35. Unique Identifier : AIDSLINE MED/99318866; Biggs TE; Cooke SJ; Barton CH; Harris MP; Saksela K; Mann DA; Southampton General Hospital, Southampton, SO16 6YD, UK.; Human immunodeficiency virus type 1 (HIV-1) Nef is important for viral infectivity and pathogenicity. HIV-1 infection is associated with inappropriate activation and defects in the function of monocytes/macrophages. We have studied the effects of HIV-1 Nef in the murine (RAW264.7) and human (THP-1) monocyte-macrophage
Ankle clonus and thiocyanate, linamarin, and inorganic sulphate excretion in school children in communities with Konzo, Mozambique.: J Trop Pediatr. 1999 Jun;45(3):139-42. Unique Identifier : AIDSLINE MED/99329414; Cliff J; Nicala D; Saute F; Givragy R; Azambuja G; Taela A; Chavane L; Gani A; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo,; Mozambique. jcliff@mail.tropical.co.mz; We examined 397 school children for ankle clonus in five communities in three districts affected by konzo, spastic paraparesis associated with cassava consumption. From a subsample of 131 children, we analysed urine specimens for urinary thiocyanate, linamarin, and inorganic sulphate. The proportion of children with c
Low birthweight in infants born to African HIV-infected women: relationship with maternal body weight during pregnancy: Pregnancy and HIV Study Group (EGE).: Unique Identifier : AIDSLINE MED/99329417; Castetbon K; Ladner J; Leroy V; Chauliac M; Karita E; De Clercq A; Van de Perre P; Dabis F; The effect of maternal HIV infection on birthweight was estimated. In the prenatal clinic of the Centre Hospitalier de Kigali, HIV screening was proposed to women with a gestational age (GA) of less than 28 weeks. HIV-infected (HIV+) and uninfected (HIV-) women were recruited, when they consented. At inclusion, socioe
HIV-related gender biases among malnourished children in Abidjan, Cote D'Ivoire.: J Trop Pediatr. 1999 Jun;45(3):169-71. Unique Identifier : AIDSLINE MED/99329422; Beau JP; Imboua-Coulibaly L; ORSTOM, Abidjan, Cote D'Ivoire.; This study, conducted in a health centre in Abidjan for malnourished children, shows that there were more girls than boys among children admitted who were HIV seropositive whereas there were more boys than girls among seronegative children. Reasons for this gender bias are investigated.
HIV test warning.: JAMA. 1999 Jul 28;282(4):317. Unique Identifier : AIDSLINE MED/99364296
From the Centers for Disease Control and Prevention. Anonymous or confidential HIV counseling and voluntary testing in federally funded testing sites--United States, 1995-1997.: JAMA. 1999 Jul 28;282(4):321-2. Unique Identifier : AIDSLINE MED/99358968
Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study Group [see comments]: JAMA. 1999 Jul 28;282(4):331-40. Unique Identifier : AIDSLINE MED/99358977; Corey L; Langenberg AG; Ashley R; Sekulovich RE; Izu AE; Douglas JM Jr; Handsfield HH; Warren T; Marr L; Tyring S; DiCarlo R; Adimora AA; Leone P; Dekker CL; Burke RL; Leong WP; Straus SE; University of Washington, Seattle, USA.; CONTEXT: In the last 3 decades, herpes simplex virus type 2 (HSV-2) infection seroprevalence and neonatal herpes have increased substantially. An effective vaccine for the prevention of genital herpes could help control this epidemic. OBJECTIVE: To evaluate the efficacy of a vac
Needlestick injuries and subsequent disease: first-person accounts from 3 nurses.: J Emerg Nurs. 1999 Apr;25(2):93-101. Unique Identifier : AIDSLINE MED/99199169; Algie BA; Arnold L; Fowler CL; Retractable Technologies, Inc, Little Elm, Texas, USA.
Gene targeting: applications in transplantation research.: Kidney Int. 1999 Jul;56(1):18-27. Unique Identifier : AIDSLINE MED/99340489; Mannon RB; Coffman TM; Division of Nephrology, Department of Medicine, Duke University; and Veterans Affairs Medical Center, Durham, North Carolina; 27705, USA.; Gene targeting, the manipulation of gene in the mouse genome using homologous recombination in embryonic stem cells, is a powerful experimental tool that has been widely utilized in a number of disciplines. The ability to precisely alter genes in this way provides an avenue for investigating the role of a gene product
Hyperkalemia in patients infected with the human immunodeficiency virus: involvement of a systemic mechanism.: Kidney Int. 1999 Jul;56(1):198-205. Unique Identifier : AIDSLINE MED/99340507; Caramelo C; Bello E; Ruiz E; Rovira A; Gazapo RM; Alcazar JM; Martell N; Ruilope LM; Casado S; Fernandez Guerrero M; Fundacion Jimenez Diaz, Hospital Clinico and Hospital 12 de; Octubre, Universidad Autonoma, Madrid, Spain. ccaramelo@fjd.es; BACKGROUND: The appearance of hyperkalemia has been described in human immunodeficiency virus (HIV)-positive patients treated with drugs with amiloride-like properties. Recent in vitro data suggest that individuals infected with HIV have alterations in transcellular K+ transport. METHODS: With the objective of examini
Monocyte expression of adhesion molecules in HIV-infected patients: variations according to disease stage and possible pathogenic role.: Lab Invest. 1999 Jul;79(7):815-22. Unique Identifier : AIDSLINE MED/99345163; Pillet S; Prevost MH; Preira A; Girard PM; Rogine N; Hakim J; Gougerot-Pocidalo MA; Elbim C; INSERM U 479 and Service d'Immunologie et d'Hematologie, CHU X,; Bichat, Paris, France.; We used flow cytometry to study the expression of adhesion molecules at the cell surface and actin polymerization of whole-blood monocytes in 35 HIV-infected patients at different stages of the disease. Monocytes were activated in vivo, as demonstrated by increased expression of the adhesion molecule CD11b/CD18, reduc
Cyno-EBV (EBV-related herpesvirus from cynomolgus macaques) induces rabbit malignant lymphomas and their tumor cell lines frequently show specific chromosomal abnormalities.: Lab Invest. 1999 Jul;79(7):823-35. Unique Identifier : AIDSLINE MED/99345164; Hayashi K; Chen HL; Yanai H; Koirala TR; Ohara N; Teramoto N; Oka T; Yoshino T; Takahashi K; Miyamoto K; Fujimoto K; Yoshikawa Y; Akagi T; Second Department of Pathology, Okayama University Medical; School, Okayama-city, Japan. kazuhaya@med.okayama-u.ac.jp; Malignant lymphoma (ML) induction in rabbits by Epstein-Barr virus (EBV)-related herpesvirus of cynomolgus (Cyno-EBV) is reported. Twenty-seven of 30 (90%) rabbits inoculated intravenously with Cyno-EBV-producing simian (cynomolgus) lymphocyte cell line (Ts-B6) cells developed ML between 45 and 115 days after inoculat
[Optimization of HIV diagnosis using the RT-PCR (gag) method with various dilutions of cDNA and MgCl2 molarity]: Med Arh. 1999;53(2):73-6. Unique Identifier : AIDSLINE MED/99313818; Subasic D; Konjhodzic R; Seric K; Institut za mikrobiologiju, imunologiju i parazitologiju,; Klinicki centar Univerziteta u Sarajevu.; Lack of optimum conditions for PCR can lead to absence of desired PCR products, undefined multiplication and appearance of unwanted products. So, the use of PCR aiming to generate large amounts of target nucleic acid sequences, may be so called double-edged sword . The important parameters in optimisation of PCR meth
[HHV 6,7 and 8. Recently discovered herpesviruses explain the etiology of well-known diseases]: Lakartidningen. 1999 Jun 30;96(26-27):3161-5. Unique Identifier : AIDSLINE MED/99352774; Bergstrom T; Virologiska laboratoriet, Sahlgrenska; Universitetssjukhuset/Sahlgrenska, Goteborg.; tomas.bergstrom@microbio.gu.se; Three new members of the family of human herpesviruses (HHVs) have been identified in less than a decade, HHV 67 and 8. HHV-6 and HHV-7, both infecting T-lymphocytes and phylogenetically related to cytomegalovirus , were identified as causative agents of exanthema subitum. In additi
Time to genotype for selection of antiretroviral regimens in previously treated patients? [comment]: Lancet. 1999 Jun 26;353(9171):2173-4. Unique Identifier : AIDSLINE MED/99320146; Falloon J; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.
Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial [see comments]: Lancet. 1999 Jun 26;353(9171):2195-9. Unique Identifier : AIDSLINE MED/99320155; Durant J; Clevenbergh P; Halfon P; Delgiudice P; Porsin S; Simonet P; Montagne N; Boucher CA; Schapiro JM; Dellamonica P; Department of Infectious Diseases, Archet Hospital, Nice, France.; BACKGROUND: Growing evidence has linked HIV-1 resistance mutations and drug failure. The use of genotypic-resistance analysis to assist therapeutic decision-making in patients failing therapy has not been investigated. We assessed the virological and immunological impact of genotypic-resistance testing. METHODS: We di
Sex education is key to combatting AIDS in Brazil [news]: Lancet. 1999 Jun 26;353(9171):2221. Unique Identifier : AIDSLINE MED/99320169; Csillag C
Prevention of vertical HIV-1 transmission [letter]: Lancet. 1999 Jun 26;353(9171):2240. Unique Identifier : AIDSLINE MED/99320175; Skinner J; Turner MJ
Prevention of vertical HIV-1 transmission [letter]: Lancet. 1999 Jun 26;353(9171):2240-1. Unique Identifier : AIDSLINE MED/99320176; Anderson JR; Hanna G; Gurewitsch E
Prevention of vertical HIV-1 transmission [letter]: Lancet. 1999 Jun 26;353(9171):2241. Unique Identifier : AIDSLINE MED/99320177; Shields JW
Making AIDS a business imperative [editorial]: Lancet. 1999 Jul 3;354(9172):1. Unique Identifier : AIDSLINE MED/99332985
HIV infection: where have all the T cells gone?: Lancet. 1999 Jul 3;354(9172):5-7. Unique Identifier : AIDSLINE MED/99332989; Rowland-Jones S; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, UK.
Home HIV kits unreliable [news]: Lancet. 1999 Jul 3;354(9172):55. Unique Identifier : AIDSLINE MED/99333009
Rapid assessment, injecting drug use, and public health.: Unique Identifier : AIDSLINE MED/99333013; Rhodes T; Stimson GV; Fitch C; Ball A; Renton A; Department of Social Science and Medicine, Imperial College; School of Medicine, University of London, UK. t.rhodes@ic.ac.uk
ApoE genotype and protease-inhibitor-associated hyperlipidaemia [letter]: Lancet. 1999 Jul 3;354(9172):76. Unique Identifier : AIDSLINE MED/99333029; Behrens G; Schmidt HH; Stoll M; Schmidt RE
Immunotherapy with Mycobacterium vaccae in patients with newly diagnosed pulmonary tuberculosis: a randomised controlled trial. Durban Immunotherapy Trial Group [see comments]: Lancet. 1999 Jul 10;354(9173):116-9. Unique Identifier : AIDSLINE MED/99334972; BACKGROUND: Mycobacterium vaccae, an environmental saprophyte, has immunogenic properties that enhance the host immune response. Immunotherapy with M. vaccae has been suggested to shorten short-course antituberculosis chemotherapy. We tested the hypothesis that the addition of M. vaccae to standard short-course antitu
Testing time as resistant HIV-1 faces next wave of attack [news]: Lancet. 1999 Jul 10;354(9173):135. Unique Identifier : AIDSLINE MED/99334984; Mellors J
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load. Pediatric AIDS Clinical Trials Group 076 Study Group [letter]: Lancet. 1999 Jul 10;354(9173):156; discussion 157-8. Unique Identifier : AIDSLINE MED/99334990; Shapiro DE; Sperling RS; Coombs RW
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [letter]: Lancet. 1999 Jul 10;354(9173):156-8. Unique Identifier : AIDSLINE MED/99334991; Wilson D
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [letter]: Lancet. 1999 Jul 10;354(9173):158. Unique Identifier : AIDSLINE MED/99334992; Wolffers I
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [letter]: Lancet. 1999 Jul 10;354(9173):158-9. Unique Identifier : AIDSLINE MED/99334993; Golden B; Cooper E; Cundall D; Moy R
Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation.: Life Sci. 1999;65(4):355-68. Unique Identifier : AIDSLINE MED/99347790; He XH; Shaw PC; Tam SC; Department of Physiology, The Chinese University of Hong Kong,; Shatin, N.T.; PEG modification (PEGylation) has been shown to reduce immunogenicity and prolong circulating half-life of proteins. In the present study, site-directed PEGylation was used to reduce immunogenicity and prolong plasma half-life of trichosanthin (TCS). Four TCS mutants, i.e. S7C, Q219C, K173C and [K173C,Q219C] (KQ), wer
Bio-ethical and legal issues in relation to HIV/AIDS: the Uganda experience.: Med Law. 1998;17(4):619-24. Unique Identifier : AIDSLINE MED/99325244; Yusuf NK; In Uganda , as in many other countries, there is a vacuum regarding an appropriate legal and ethical response to the HIV/AIDS pandemic. Whereas much has been done to address the HIV/AIDS pandemic in a multidisciplinary way, very little has been done regarding legal and ethical issue
Anti-HIV-1 activity of an ionically modified porous polypropylene membrane determined by filtration of a viral suspension.: Microbiol Immunol. 1999;43(2):141-51. Unique Identifier : AIDSLINE MED/99244274; Owada T; Miyashita Y; Motomura T; Onishi M; Yamashita S; Yamamoto N; Department of New Materials Section, Terumo Research and; Development Center, Hadano, Kanagawa, Japan. JZG00166@nifty.ne.jp; We describe here a unique anti-HIV-1 membrane, derived from a chemically modified porous polypropylene (PP) membrane, which lowers viral infectivity upon the filtration of HIV-1 suspension. A cationic polymer, polyethyleneimine (PEI) was graft-polymerized onto the PP filter membrane (PP-PEI), and infectious HIV-1(HTLV
High molecular weight dextran sulfate increases the activity of NF-kappaB-regulated promoter in monocyte-derived macrophages.: Microbiol Immunol. 1999;43(2):187-9. Unique Identifier : AIDSLINE MED/99244281; Jagodzinski PP; Trzeciak WH; Department of Physiological Chemistry, University of Medical; Sciences, Poznan, Poland.; It is known that sulfated polysaccharides can mimic the action of common T-cell mitogens. To investigate the molecular basis of the mitogenic effect of high molecular weight dextran sulfate (HMDS), monocyte-derived macrophages were transfected with recombinant plasmid containing chloramphenicol acetyl transferase (CAT
Denervation enhances spontaneous inflammatory myopathy in SJL mice.: Muscle Nerve. 1999 Jul;22(7):883-8. Unique Identifier : AIDSLINE MED/99326966; Kampman MT; Benestad SL; Fladby T; Maehlen J; Department of Neurology, University Hospital of Tromso, 9038; Tromso, Norway.; We studied the effect of denervation on the spontaneous inflammatory myopathy that occurs in SJL mice. Cryosections from innervated and denervated calf muscles were assessed for severity of inflammation, relative proportions of mononuclear cell subsets, and major histocompatibility complex (MHC) class I expression. A
Case report. Successful therapy of disseminated histoplasmosis in AIDS with liposomal amphotericin B [letter]: Mycoses. 1999 Apr;42(1-2):117-20. Unique Identifier : AIDSLINE MED/99323172; Rieg GK; Shah PM; Helm EB; Just-Nubling G; A 36-year-old HIV-infected male patient presented with relapsing fever episodes to 39 degrees C, night sweats and weight loss. Computerized tomography of the abdomen showed enlarged multiple lymph nodes. After surgical resection of multiple lymph nodes, disseminated infection with Histoplasma capsulatum was diagnosed.
Oropharyngeal candidosis in AIDS patients: an epidemiological study using restriction analysis of Candida albicans total genomic DNA.: Mycoses. 1999 Apr;42(1-2):41-6. Unique Identifier : AIDSLINE MED/99323159; Elias Costa MR; Carnovale S; Relloso MS; Departamento de Microbiologia, Facultad de Medicina, Universidad; de Buenos Aires, Argentina.; This study investigates the epidemiology of Candida albicans strains isolated from oral and rectal swabs obtained before and after treatment with antifungal drugs in hospitalized AIDS patients. Twenty-one health care workers from the hospital unit were also studied. Samples were obtained from the oral cavity and hands
In vitro activity of rilopirox against fluconazole-susceptible and fluconazole-resistant Candida isolates from patients with HIV infection.: Mycoses. 1999 Apr;42(1-2):55-60. Unique Identifier : AIDSLINE MED/99323161; Nenoff P; Taneva E; Pfeil B; Oswald U; Haustein UF; Department of Dermatology, University of Leipzig, Germany.; The in vitro antifungal activity of the new hydroxypyridone antimycotic rilopirox has been evaluated against 38 fluconazole-susceptible and -resistant clinical isolates of Candida albicans together with other Candida species isolated from patients with human immunodeficiency virus (HIV) infection and oropharyngeal can
Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team [see comments]: N Engl J Med. 1999 Aug 5;341(6):385-93. Unique Identifier : AIDSLINE MED/99345285; Mofenson LM; Lambert JS; Stiehm ER; Bethel J; Meyer WA 3rd; Whitehouse J; Moye J Jr; Reichelderfer P; Harris DR; Fowler MG; Mathieson BJ; Nemo GJ; Pediatric, Adolescent and Maternal AIDS Branch, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD, USA. lm65d@nih.gov; BACKGROUND: Maternal, obstetrical, and infant-related factors associated with the risk of perinatal transmission of human immunodeficiency virus type 1 (HIV-1) were identified before the widespread use of zidovudine therapy in pregnant women. The risk factors for transmission when women and infants receive zidovudine
Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group [see comments]: N Engl J Med. 1999 Aug 5;341(6):394-402. Unique Identifier : AIDSLINE MED/99345286; Garcia PM; Kalish LA; Pitt J; Minkoff H; Quinn TC; Burchett SK; Kornegay J; Jackson B; Moye J; Hanson C; Zorrilla C; Lew JF; Department of Obstetrics and Gynecology, Northwestern University,; Chicago, USA. p-garcia@nwu.edu; BACKGROUND: The importance of plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA in pregnant women in relation to the other factors known to influence the risk of transmission of infection to their infants is incompletely defined. We studied the relation of maternal plasma HIV-1 RNA levels to the risk of
Reducing the risk of maternal-infant transmission of HIV by attacking the virus [editorial; comment]: N Engl J Med. 1999 Aug 5;341(6):441-3. Unique Identifier : AIDSLINE MED/99345293; Rogers MF; Shaffer N
Acute renal failure in the course of HIV infection: a single-institution retrospective study of ninety-two patients anad sixty renal biopsies.: Nephrol Dial Transplant. 1999 Jun;14(6):1578-85. Unique Identifier : AIDSLINE MED/99310406; Peraldi MN; Maslo C; Akposso K; Mougenot B; Rondeau E; Sraer JD; Service de Nephrologie A, Hopital Tenon, Paris, France.; BACKGROUND: Acute renal failure syndromes are frequently encountered in patients with human immunodeficiency virus (HIV) infection. Most reported cases of acute renal failure are related to acute tubular necrosis, but many other causes of renal failure have been described in these patients. METHODS: The present work i
Breast-feeding, mastitis, and HIV transmission: nutritional implications.: Nutr Rev. 1999 May;57(5 Pt 1):146-53. Unique Identifier : AIDSLINE MED/99319490; Semba RD; Neville MC; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.; In many developing countries, transmission of the human immunodeficiency virus (HIV) from mother to infant occurs through breast-feeding. Mastitis, an inflammatory process in the breast, may be common in lactating women in Africa and is associated with both higher HIV load in breast milk and mother-to-child transmissi
Evaluation of young children in household contact with adult multidrug-resistant pulmonary tuberculosis cases.: Pediatr Infect Dis J. 1999 Jun;18(6):494-500. Unique Identifier : AIDSLINE MED/99318061; Schaaf HS; Vermeulen HA; Gie RP; Beyers N; Donald PR; Department of Paediatrics and Child Health, Faculty of Medicine,; University of Stellenbosch and Tygerberg Hospital, Western Cape; Province, South Africa.; BACKGROUND: The prevention and management of multidrug-resistant (MDR) tuberculosis has received much attention, but little attention has been given to children with MDR tuberculosis or children in contact with adults with MDR tuberculosis. The aim of this study was to determine the prevalence of tuberculous infection
Effect of changing antiretroviral therapy on human immunodeficiency virus viral load: experience with fifty-four perinatally infected children.: Pediatr Infect Dis J. 1999 Jun;18(6):512-6. Unique Identifier : AIDSLINE MED/99318064; Purswani M; Johann-Liang R; Cervia J; Noel GJ; Department of Pediatrics, The New York Hospital-Cornell Medical; Center, NY, USA.; BACKGROUND: Experience in adults has shown that combination therapy including HIV protease inhibitors (PI) can profoundly affect viral replication and slow progression of HIV-associated disease. Trials defining the i
Spirituality and people with potentially fatal diagnoses.: Nurs Forum. 1999 Jan-Mar;34(1):13-22. Unique Identifier : AIDSLINE MED/99354865; Fryback PB; Reinert BR; College of Nursing, University of Southern Mississippi,; Hattiesburg, USA.; When individuals must deal with potentially fatal diseases their lives change in many ways. This qualitative study was designed to investigate this critical life event. The authors interviewed a convenience sample (N = 15) of 10 women with cancer and 5 men with HIV/AIDS. Findings suggest that spirituality is an essent
[Psoriasis. Clinical cutaneous aspects]: Presse Med. 1999 Jun 26;28(23):1246-50. Unique Identifier : AIDSLINE MED/99349380; Passeron T; Bahadoran P; Lacour JP; Ortonne JP; Service de Dermatologie, Hopital de l'Archet, Nice.; PREDOMINANT FEATURES: Psoriasis is a frequent inflammatory dermatosis. All age groups are involved. The typical lesion is a well-limited erythemato-squamaous non-pruriginous lesion. All skin areas may be involved but each individual has preferential zones. CLINICAL COURSE: This chronic condition progresses by acute fl
The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease.: Proteins. 1999 Aug 1;36(2):147-56. Unique Identifier : AIDSLINE MED/99327013; Todd MJ; Freire E; Department of Biology and Biocalorimetry Center, The Johns; Hopkins University, Baltimore, Maryland 21218, USA.; The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25 degrees C and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 x 10(7 )M-1 and an enthalpy of 7.3 +/- 0.5 kcal/mol, indic
[The number of people in Germany living with HIV infection has reached a new high (news)]: Pharm Unserer Zeit. 1999 May;28(3):158-9. Unique Identifier : AIDSLINE MED/99327665
[AIDS and HIV infections in 1997]: Przegl Epidemiol. 1999;53(1-2):171-9. Unique Identifier : AIDSLINE MED/99331276; Szata W; Zaklad Epidemiologii Panstwowego, Zakladu Higieny, Warszawa.; In Poland 114 AIDS cases and 579 newly discovered HIV infections have been registered in 1997. Annual numbers of diagnosed and notified AIDS cases and HIV infections were rather stable during last years. The nearest future of HIV/AI
[Primary resistance of Mycobacterium tuberculosis in 10 hospitals of the community of Castille and Leon. Group of Microbiologists from Castille and Leon]: Rev Clin Esp. 1999 Mar;199(3):132-5. Unique Identifier : AIDSLINE MED/99246905; Alberte Castineiras A; Perez Pascual P; Servicio de Microbiologia, Hospital del Rio Hortega,; Valladolid.; OBJECTIVE: To determine the primary drug resistance (PDR) of Mycobacterium tuberculosis in ten hospitals in the Castile-Leon Community for a five-year period (1991-1995), in a sanitary area with almost two millions of inhabitants. MATERIAL AND METHODS: The sensitivity of 825 strains of Mycobacterium tuberculosis to an
[Primary cerebral lymphoma associated with AIDS: clinical profile, diagnostic criteria and therapeutic development]: Rev Clin Esp. 1999 Mar;199(3):161-6. Unique Identifier : AIDSLINE MED/99246911; Rubio Rodriguez MC; Rubio Garcia R; Calvo Manuel FA; Instituto Madrileno de Oncologia, Madrid.
[Tests to detect resistance to antiretroviral agents in clinical practice]: Unique Identifier : AIDSLINE MED/99246918; Seriano Vazquez V; Rodriguez-Rosado y Martinez-Echevarria R; Martinez-Echevarria; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
[Reduction of the incidence of tuberculosis following the introduction of new treatments against HIV (letter)]: Rev Clin Esp. 1999 Mar;199(3):186-7. Unique Identifier : AIDSLINE MED/99246921; Castilla Catalan J; Guerra Romero L; Canon Campos J; Noguer Zambrano I; Parras Vazquez F
[Potential opiate withdrawal syndrome after ritonavir administration in a patient treated with methadone (letter)]: Rev Clin Esp. 1999 Mar;199(3):188-9. Unique Identifier : AIDSLINE MED/99246923; Jimenez-Lerma JM; Iraurgi I
[Indinavir-induced anuria (letter)]: Rev Clin Esp. 1999 Mar;199(3):189. Unique Identifier : AIDSLINE MED/99246924; Lacambra Calvet C; Eroles Vega G; Plaza Canteli S; Solis Villa J
Prevention of graft versus host disease by inactivation of host antigen-presenting cells.: Science. 1999 Jul 16;285(5426):412-5. Unique Identifier : AIDSLINE MED/99340301; Shlomchik WD; Couzens MS; Tang CB; McNiff J; Robert ME; Liu J; Shlomchik MJ; Emerson SG; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia, PA 19104, USA.; Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine allogeneic bone marrow transplantation model it was found that,
Demograghic and socio-economic determinants of community and hospital services costs for people with HIV/AIDS in London.: Soc Sci Med. 1999 May;48(10):1433-40. Unique Identifier : AIDSLINE MED/99296133; Kupek E; Dooley M; Whitaker L; Petrou S; Renton A; Department of Public Health, Centro de Ciencias de Saude,; Universidade Federal de Santa Catarina, Florianopolis-SC, Brazil.; kupek@cfh.ufsc.br; We examined the influence of demographic, social and economic background of people with HIV/AIDS in London on total community and hospital services costs. This was a retrospective study of community and hospital service use, needs and costs based on structured questionnaires administered by trained interviewers and co
Doing a shotgun: a drug use practice and its relationship to sexual behaviors and infection risk.: Soc Sci Med. 1999 May;48(10):1441-8. Unique Identifier : AIDSLINE MED/99296134; Perlman DC; Henman AR; Kochems L; Paone D; Salomon N; Des Jarlais DC; Beth Israel Medical Center, New York, NY 10003, USA.; perlman@aecom.yu.edu; There has been a rise in the frequency with which inhalational routes such as smoking are used for illicit drug use. A growing population of new inhalational drug users augments the pool of individuals at risk for transition to injection drug use. Further, illicit drug smoking has been implicated in the transmission o
HIV/AIDS in nonurban Alabama: risk activities and access to services among HIV-infected persons.: South Med J. 1999 Jul;92(7):677-83. Unique Identifier : AIDSLINE MED/99341426; Beltrami JF; Vermund SH; Fawal HJ; Moon TD; Von Bargen JC; Holmberg SD; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, GA, USA.; BACKGROUND: Because AIDS is increasing in rural areas and small cities of the United States , we sought to further describe the epidemiology of HIV/AIDS in nonurban Alabama. METHODS: Extensive interviews of HIV-infected residents of Alabama living outside of urban Birmingham were conduc
Manifestations of AIDS in the head and neck.: South Med J. 1999 Jul;92(7):684-97. Unique Identifier : AIDSLINE MED/99341427; Reisacher WR; Finn DG; Stern J; Zeifer B; Cocker R; Department of Otolaryngology, The New York Eye and Ear Infirmary,; NY, USA.; BACKGROUND: A significant number of patients with the acquired immunodeficiency syndrome (AIDS) are initially seen with symptoms related to the head and neck. It is becoming increasingly challenging for clinicians to accurately diagnose new lesions, considering the vast array of manifestations of AIDS in this region a
Learning from success: global priorities for HIV prevention--Thomas Parran Award Lecture.: Sex Transm Dis. 1999 May;26(5):244-9. Unique Identifier : AIDSLINE MED/99264071; Piot P; UNAIDS, Joint United Nations Programme on HIV/AIDS, Geneva,; Switzerland.
Sexual activity, substance use, and HIV/STD knowledge among detained male adolescents with multiple versus first admissions.: Sex Transm Dis. 1999 May;26(5):265-71. Unique Identifier : AIDSLINE MED/99264074; Harwell TS; Trino R; Rudy B; Yorkman S; Gollub EL; Department of Community and Preventive Medicine, Allegheny; University of the Health Sciences, Philadelphia, Pennsylvania,; USA. tharwell@state.mt.us; BACKGROUND: Incarcerated and detained youth are at high risk for sexually transmitted diseases (STD), including human immunodeficiency virus (HIV). GOAL OF THE STUDY: To compare the level of sexual activity and substance use-related risk and knowledge regarding HIV/STD among male adolescents with multiple (YMA) versus
Disclosure of HIV status to sexual partners: predictors and temporal patterns.: Sex Transm Dis. 1999 May;26(5):281-5. Unique Identifier : AIDSLINE MED/99264077; Niccolai LM; Dorst D; Myers L; Kissinger PJ; HIV Outpatient Program, Louisiana State University Medical; Center, New Orleans 70112, USA. Iniccol@mailhost.tcs.tulane.edu; BACKGROUND AND OBJECTIVES: Failure to disclose human immunodeficiency virus (HIV) infection to sexual partners interferes with risk reduction. GOAL OF THIS STUDY: The purpose of this study was to identify factors associated with disclosure and failure to disclose HIV infection to sexual partners and to describe condom
HIV surveillance: a dynamic, not static, process to assure accurate local data.: Sex Transm Dis. 1999 May;26(5):291-5. Unique Identifier : AIDSLINE MED/99264079; Griffin RG; Wilkinson TH; Hoff GL; Kansas City Health Department, Communicable Disease Prevention; Program, Missouri 64108, USA. ron_griffin@kcmo.org; BACKGROUND AND OBJECTIVES: Accurate human immunodeficiency virus (HIV) surveillance data is critical for the allocation of resources for care services and community prevention planning efforts. GOAL OF THIS STUDY: To validate HIV status of women and assess risk factor information on all persons reported with either he
Tuberculosis in AIDS: past or new problems? [editorial]: Thorax. 1999 Jul;54(7):567-71. Unique Identifier : AIDSLINE MED/99307471; Mayaud C; Cadranel J
Episcleritis associated with pigmentary retinal degeneration in an HTLV-I carrier.: Tokai J Exp Clin Med. 1998 Oct;23(4):183-5. Unique Identifier : AIDSLINE MED/99286067; Nomura E; Kimura T; Yabuki K; Kurita M; Goto K; Ohno S; Department of Ophthalmology, Yokohama City University School of; Medicine, Japan.; Human T-cell lymphotropic virus type I (HTLV-I) has been reported as the cause of a kind of endogenous uveitis (HTLV-I associated uveitis; HAU). We observed a case of episcleritis in a HTLV-I carrier with pigmentary retinal degeneration. HTLV-I infection might be associated with the development of episcleritis and pig
High-performance liquid chromatography method for analyzing the antiretroviral agent efavirenz in human plasma.: Ther Drug Monit. 1999 Jun;21(3):346-50. Unique Identifier : AIDSLINE MED/99291773; Villani P; Pregnolato M; Banfo S; Rettani M; Burroni D; Seminari E; Maserati R; Regazzi MB; Department of Pharmacology, IRCCS Policlinico S. Matteo, Italy.; Efavirenz (EFV, DMP-266) is a new antiretroviral agent belonging to the class of nonnucleoside reverse transcriptase inhibitors. It has recently been approved by the Food and Drug Administration in management of human immunodeficiency virus (HIV). Pre
Determination of indinavir, a HIV-1 protease inhibitor, in human plasma using ion-pair reversed-phase high-performance liquid chromatography.: Ther Drug Monit. 1999 Jun;21(3):360-6. Unique Identifier : AIDSLINE MED/99291776; Li W; Coombs RW; Collier AC; Raisys VA; Department of Laboratory Medicine, University of Washington,; Seattle, USA.; Indinavir is widely prescribed as a component of potent antiretroviral therapy for the treatment of HIV-1 infection. Because virologic failure of therapy can result from subtherapeutic drug levels, monitoring of indinavir levels may be important in cl
The fate of donor T-cell receptor transgenic T cells with known host antigen specificity in a graft-versus-host disease model.: Transplantation. 1999 Jul 15;68(1):141-9. Unique Identifier : AIDSLINE MED/99355236; Dey B; Yang YG; Preffer F; Shimizu A; Swenson K; Dombkowski D; Sykes M; Transplantation Biology Research Center/Surgical Service, and; Department of Pathology, Massachusetts General Hospital/Harvard; Medical School, Boston 02129, USA.; BACKGROUND: The expansion of transgenic donor CD8+ T-cells with known allospecificity against a host MHC class I alloantigen was examined in a murine graft-versus-host disease (GVHD) model. METHODS: Lethally irradiated, Ld+ BALB/c mice received bone marrow cells and spleen cells from anti-Ld 2C T-cell receptor (TCR)-t
The effect of methimazole, iodine and splenocytes on thyroid transplants in BB/Wor rats.: Transplantation. 1999 Jul 15;68(1):25-30. Unique Identifier : AIDSLINE MED/99355216; Allen EM; Bartlett ST; Department of Medicine University of Maryland Medical System and; Baltimore VA Medical Center, 21201-1595, USA.; BACKGROUND: BB/Wor rats develop spontaneous autoimmune insulin-requiring diabetes mellitus and lymphocytic thyroiditis (LT). Our investigations examined the effect of the thyroid-specific agents, iodine and methimazole (MMI) on thyroid graft survival in BB/Wor rats, compared the intrathyroidal cytokine mRNA expression
Mechanisms of tolerance induction after intrathymic islet injection: determination of the fate of alloreactive thymocytes.: Transplantation. 1999 Jul 15;68(1):30-9. Unique Identifier : AIDSLINE MED/99355217; Turvey SE; Hara M; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, United Kingdom.; BACKGROUND: Intrathymic (IT) administration of antigen when combined with peripheral T-cell depletion has been shown to induce operational tolerance in a wide range of experimental protocols. IT injection of pancreatic islets has been demonstrated not only to induce tolerance to alloantigen but also to prevent the dev
A case of intestinal Mycobacterium simiae infection in an SIV-infected immunosuppressed rhesus monkey.: Vet Pathol. 1999 May;36(3):249-52. Unique Identifier : AIDSLINE MED/99265237; Didier A; Matz-Rensing K; Kuhn EM; Richter E; Kaup FJ; Abteilung Tiermedizin und Primatenhaltung, Deutsches; Primatenzentrum, Gottingen, Germany. adidier@www.dpz.gwdg.de; Although Mycobacterium simiae was identified and classified more than three decades ago, only a few cases are mentioned in the current literature. After experimental simian immunodeficiency virus infection, a 9-year-old female rhesus monkey (Macaca mulatta) developed progressive immunosuppression and gastrointestinal
Interferon-gamma and interleukin-2 release by lymphocytes derived from the blood, mesenteric lymph nodes and intestines of normal sheep and those affected with paratuberculosis (Johne's disease).: Vet Immunol Immunopathol. 1999 May;68(2-4):139-48. Unique Identifier : AIDSLINE MED/99314910; Burrells C; Clarke CJ; Colston A; Kay JM; Porter J; Little D; Sharp JM; Moredun Research Institute, International Research Centre, Bush; Loan, Penicuik, UK. charles.burrells@cultor.com; This study sought to determine if T-cell cytokine responses to mycobacterial infections in sheep were similar to those in other species and if such responses correlated with prevailing gut pathology. Lymphocytes were isolated from the blood (PBL), mesenteric lymph nodes (MLN) and ileal lamina propria (LPL) of control
Bovine interleukin-12 and modulation of IFNgamma production.: Vet Immunol Immunopathol. 1999 May;68(2-4):193-207. Unique Identifier : AIDSLINE MED/99314916; Collins RA; Howard CJ; Duggan SE; Werling D; Division of Immunology and Pathology, Institute for Animal; Health, Newbury, Berkshire, UK. collinsr@bbsrc.ac.uk; The effects of IL-12 on the responses of cattle peripheral blood mononuclear cells (PBMC) to bovine respiratory syncytial virus (BRSV) antigen and ovalbumin (OVA) were tested, in vitro. IL-12 did not affect the proliferative responses of PBMC to these antigens but markedly accelerated and augmented the level of IFNgam
Up-regulation of tumor necrosis factor alpha mRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection.: Vet Immunol Immunopathol. 1999 May;68(2-4):255-65. Unique Identifier : AIDSLINE MED/99314920; Kabeya H; Ohashi K; Oyunbileg N; Nagaoka Y; Aida Y; Sugimoto C; Yokomizo Y; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Sapporo, Japan.; Protective immune responses were analyzed in eight sheep vaccinated with BLV envelope peptides and experimentally infected with bovine-leukemia virus (BLV). Five of eight peptide-immunized sheep showed a high T-cell proliferative response to the BLV peptides and all of these were protected from the infection. The othe
Safe and effective use of combination antiretroviral treatment.: Acta Clin Belg. 1999 Apr;54(2):55-60. Unique Identifier : AIDSLINE MED/99322945; Colebunders R; Clumeck N; Florence E; Vandercam B; Van Wanzeele F; Van Wijngaerden E; Lacor P; Demonty J; De Wit S; Institute of Tropical Medicine, Department of Clinical Sciences,; Antwerpen, Belgium. bcoleb@itg.be
Belgian consensus recommendations for flow cytometric immunophenotyping. The Belgian Association for Cytometry/Belgische Vereniging voor Cytometrie/Association Belge de Cytometrie.: Acta Clin Belg. 1999 Apr;54(2):88-98. Unique Identifier : AIDSLINE MED/99322950; Van Bockstaele DR; Deneys V; Philippe J; Bernier M; Kestens L; Chatelain B; De Waele M; Demanet C; Universitair Ziekenhuis Antwerpen (UZA/UIA), Laboratorium; Hematologie.; This paper summarises the guidelines and recommendations that were generated during a number of discussion forums attended by the majority of Belgian cytometry laboratory professionals. These forums focused on the rational and optimal use of flow cytometric evaluations in the clinical laboratory setting. The aim was t
Child survival in children born to HIV-2 infected women in Guinea-Bissau, West Africa.: Acta Trop. 1999 Apr 30;72(3):309-15. Unique Identifier : AIDSLINE MED/99247771; Norrgren H; Fonseca A; Andersson S; Dias F; Naucler A; Biberfeld G; National Public Health Laboratory LNSP, Bissau, Guinea-Bissau.; hans.norrgren@infek.lu.se; We have retrospectively studied the effect of maternal HIV-2 infection and other risk factors on child survival at a family planning centre in Bissau, Guinea-Bissau . A total of 2109 women were included, and the seroprevalence of HIV-2 was 5.7%. Overall child mortality of all live
Herbs' benefits and risks [letter]: Am J Nurs. 1999 Jul;99(7):14. Unique Identifier : AIDSLINE MED/99338277; Badten K
Medication compliance [letter]: Am J Nurs. 1999 Jul;99(7):14. Unique Identifier : AIDSLINE MED/99338276; Hall L
We are diminished by one. Just one nurse, with a remarkable dedication.: Am J Nurs. 1999 Jul;99(7):25. Unique Identifier : AIDSLINE MED/99338282; McCabe B; Mount Sinai Medical Center, New York, NY, USA.
[Anonymous serological screening for HIV infection in umbilical cord blood by the pooled-batch system]: An Esp Pediatr. 1999 Jun;50(6):603-6. Unique Identifier : AIDSLINE MED/99338613; Ochoa Sangrador C; Brezmes Valdivieso P; Carrascal Tejado A; Perez Carretero J; Castano Almendral JL; Servicio de Pediatria, Hospital Virgen de la Concha, Zamora.; OBJECTIVE: The aim of this study was to estimate the sero-prevalence of HIV infections in pregnant women of the health area of Zamora, Spain by unlinked anonymous screening and to estimate the percentage of non-diagnosed cases by non-systematic screening. PATIENTS AND METHODS: Umbil
Use of real-time PCR and fluorimetry to detect lamivudine resistance-associated mutations in hepatitis B virus.: Antimicrob Agents Chemother. 1999 Jul;43(7):1600-8. Unique Identifier : AIDSLINE MED/99318585; Cane PA; Cook P; Ratcliffe D; Mutimer D; Pillay D; PHLS Antiviral Susceptibility Reference Unit, Division of; Immunity and Infection, University of Birmingham Medical School,; Birmingham B15 2TT, United Kingdom. p.cane@bham.ac.uk; Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut
Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients.: Antimicrob Agents Chemother. 1999 Jul;43(7):1621-30. Unique Identifier : AIDSLINE MED/99318588; Lopez-Ribot JL; McAtee RK; Perea S; Kirkpatrick WR; Rinaldi MG; Patterson TF; Department of Medicine, The University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78284, USA.; ribot@uthscsa.edu; Mechanisms of resistance to azoles in Candida albicans, the main etiologic agent of oropharyngeal candidiasis (OPC), include alterations in the target enzyme (lanosterol demethylase) and increased efflux of drug. Previous studies on mechanisms of resistance have been limited by the fact that only a single isolate from
Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals.: Antimicrob Agents Chemother. 1999 Jul;43(7):1674-80. Unique Identifier : AIDSLINE MED/99318596; Brindeiro R; Vanderborght B; Caride E; Correa L; Oravec RM; Berro O; Stuyver L; Tanuri A; Departamento de Genetica, Instituto de biologia, Rio de Janeiro,; Brazil.; The presence of human immunodeficiency virus type 1 (HIV-1) bearing mutations resistant to nucleosidic inhibitors of the viral reverse transcriptase (RT) derived from HIV-seropositive asymptomatic and untreated volunteer blood donors was examined. The RT amplicons of 32 specimens were analyzed by using a reverse hybri
Safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus (HIV) type 1 protease inhibitor, following oral administration of single doses to HIV-infected adults.: Antimicrob Agents Chemother. 1999 Jul;43(7):1686-92. Unique Identifier : AIDSLINE MED/99318598; Sadler BM; Hanson CD; Chittick GE; Symonds WT; Roskell NS; Glaxo Wellcome Inc., Research Triangle Park, North Carolina; 27709, USA. bms44974@glaxowellcome.com; We conducted a double-blind, placebo-controlled, parallel, dose-escalation trial to evaluate the pharmacokinetics and safety of single, oral doses of amprenavir (141W94; formerly VX-478), a potent inhibitor of human immunodeficiency virus (HIV) type 1 protease, administered as hard gelatin capsules in 12 HIV-infected
Single-dose pharmacokinetics and safety of abacavir (1592U89), zidovudine, and lamivudine administered alone and in combination in adults with human immunodeficiency virus infection.: Antimicrob Agents Chemother. 1999 Jul;43(7):1708-15. Unique Identifier : AIDSLINE MED/99318602; Wang LH; Chittick GE; McDowell JA; Glaxo Wellcome Inc., Research Triangle Park, North Carolina; 27709, USA.; Abacavir (1592U89), a nucleoside reverse transcriptase inhibitor with in vitro activity against human immunodeficiency virus type-1 (HIV-1), has been evaluated for efficacy and safety in combination regimens with other nucleoside analogs, including zi
Ritonavir-fluoxetine interaction [letter]: Antimicrob Agents Chemother. 1999 Jul;43(7):1815. Unique Identifier : AIDSLINE MED/99364287; Eralp Bellibas S
The S-acyl-2-thioethyl pronucleotide approach applied to acyclovir: part I. Synthesis and in vitro anti-hepatitis B virus activity of bis(S-acyl-2-thioethyl)phosphotriester derivatives of acyclovir.: Antiviral Res. 1999 Jan;40(3):167-78. Unique Identifier : AIDSLINE MED/99149897; Perigaud C; Gosselin G; Girardet JL; Korba BE; Imbach JL; Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite; Montpellier II, France. perigaud@univ-montp2.fr; The synthesis and in vitro anti-hepatitis B virus (HBV) activity of two mononucleoside phosphotriester derivatives of acyclovir incorporating S-acyl-2-thioethyl (SATE) groups are reported. In contrast to the parent nucleoside, the described phosphotriesters emerged as potent and
A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.: Antiviral Res. 1999 Feb;41(1):21-33. Unique Identifier : AIDSLINE MED/99253493; Humphrey RW; Wyvill KM; Nguyen BY; Shay LE; Kohler DR; Steinberg SM; Ueno T; Fukasawa T; Shintani M; Hayashi H; Mitsuya H; Yarchoan R; HIV and AIDS Malignancy Branch, Division of Clinical Sciences,; National Cancer Institute, NIH, Bethesda, MD 20892, USA.; The pharmacokinetics, toxicity, and activity of KNI-272, a transition state inhibitor of HIV-1 protease, was assessed in a phase I trial. After an initial phase in which the pharmacokinetics were assessed, 37 patients with AIDS or symptomatic HIV infection and 100-400 CD4 cells/mm3 were entered in an escalating dose s
A combinatorial ledge: reverse transcriptase fidelity, total body viral burden, and the implications of multiple-drug HIV therapy for the evolution of antiviral resistance.: Antiviral Res. 1999 Feb;41(1):45-56. Unique Identifier : AIDSLINE MED/99253495; Colgrove R; Japour A; Beth Israel Deaconess Medical Center, Harvard Medical School,; Boston, MA 02215, USA. robin@louis.bidmc.harvard.edu; The chronicity, high mutation rates, and high circulating titers of HIV during the stable phase of infection make rapid evolution of resistance mutations a key predictor of antiretroviral efficacy. Recent advances in measurement of viral RNA titers, turnover dynamics and the in vivo spectrum of resistance mutations
Resistance mutations selected in vivo under therapy with anti-HIV drug HBY 097 differ from resistance pattern selected in vitro.: Antiviral Res. 1999 May;42(1):15-24. Unique Identifier : AIDSLINE MED/99263934; Rubsamen-Waigmann H; Huguenel E; Shah A; Paessens A; Ruoff HJ; von Briesen H; Immelmann A; Dietrich U; Wainberg MA; Bayer Pharma Research Center, Anti-Infectives Research,; Wuppertal, Germany.; The quinoxaline derivative HBY 097, an orally active nonnucleoside inhibitor of HIV-1 reverse transcriptase (NNRTI), showed an efficient suppression of viral load in a dose-escalating phase I study with mean trough concentrations increasing from 137-1299 ug/l [Rubsamen-Waigmann et al., Lancet 349:1517]. Half-maximal i
Antiviral treatment for human immunodeficiency virus patients co-infected with hepatitis B virus: combined effect for both infections, an obtainable goal?: Antiviral Res. 1999 May;42(1):71-6. Unique Identifier : AIDSLINE MED/99263939; Wolters LM; Niesters HG; de Man RA; Schalm SW; Department of Hepatogastroenterology, University Hospital; Rotterdam, The Netherlands.; A large percentage of human immunodeficiency virus (HIV) patients have serological evidence of a past or present hepatitis B virus infection (HBV). Long-term survival is increasing for HIV patients because of highly active antiretroviral therapy. Therefore, the chronic hepatitis B infection may become an important det
Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.: Biochem Biophys Res Commun. 1999 Jul 5;260(2):453-8. Unique Identifier : AIDSLINE MED/99333698; Rajamohan F; Venkatachalam TK; Irvin JD; Uckun FM; Biotherapy Program, Hughes Institute, St. Paul, Minnesota, USA.; Pokeweed antiviral protein (PAP) is a naturally occurring broad-spectrum antiviral agent with potent anti-human immunodeficiency virus (HIV)-1 activity by an as yet undeciphered molecular mechanism. In the present study, we sought to determine if PAP is capable of recognizing and depurinating viral RNA. Depurination o
Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy.: Biochem Pharmacol. 1999 Jul 1;58(1):1-27. Unique Identifier : AIDSLINE MED/99330309; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. jan.balzarini@rega.kuleuven.ac.be; There are currently thirteen drugs approved for the treatment of human immunodeficiency virus (HIV)-infected individuals. Seven of them are targeted against the virus-encoded reverse transcriptase (RT). Appearance of drug-resistant virus strains under the selective pressure of anti-HIV chemotherapy rapidly occurs as a
Inhibition of cathepsin D by tripeptides containing statine analogs.: Biochem Pharmacol. 1999 Jul 15;58(2):329-33. Unique Identifier : AIDSLINE MED/99350038; Bessodes M; Antonakis K; Herscovici J; Garcia M; Rochefort H; Capony F; Lelievre Y; Scherman D; CNRS UMR 133, ENSCP, Paris, France. bessodes@infobiogen.fr; Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.
Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.: Biochem Pharmacol. 1999 Aug 1;58(3):431-8. Unique Identifier : AIDSLINE MED/99352047; Walle UK; Galijatovic A; Walle T; Department of Cell and Molecular Pharmacology and Experimental; Therapeutics, Medical University of South Carolina, Charleston; 29425, USA.; Chrysin (5,7-dihydroxyflavone), a natural product present in our daily diet, is a potent inhibitor of drug-metabolizing enzymes. However, its oral bioavailability is not known. This study examined the intestinal epithelial transport of chrysin (20 microM), using the human colonic cell line Caco-2 as a model of human i
Ricky Ray cliffhanger.: Common Factor. 1998 Oct;(No 12):1, 7, 9. Unique Identifier : AIDSLINE AIDS/99704322; Cavenaugh D; A version of the Ricky Ray bill may be passed by the Senate, but funding is not assured. HR 1023 is the House of Representative s hemophilia-only version of this bill. There is opposition to the bill from Jeffords (R-VT), the Chair of the Senate Health Committee and author of a competing bill. As a result, lobbying ef
The good, the bad & the ugly: the political economy of the blood products industry.: Common Factor. 1998 Oct;(No 12):4-5, 8. Unique Identifier : AIDSLINE AIDS/99704323; Dubin CS; Since 1998, the U.S. Surgeon General has recommended the use of recombinant factor concentrates for patients with hemophilia and other clotting disorders, rather than human derived factor concentrates. With the increased risk of HIV and HCV for these patients, studies show that using the recombinant factor gives them
Problem with Norvir capsules.: Posit Aware. 1998 Sep-Oct;9(5):16. Unique Identifier : AIDSLINE AIDS/99704324; Abbott Laboratories , the manufacturer of Norvir ( Ritonavir ), has announced a problem with the production of their Norvir capsules. This problem a
Thalidomide approved.: Posit Aware. 1998 Sep-Oct;9(5):16. Unique Identifier : AIDSLINE AIDS/99704325; The FDA has approved the use of Thalidomide (Thalomid) for treating a leprosy-associated condition. However, Thalidomide can also be used for HIV-related conditions if a physician prescribes it for off-label use . In HIV-positive people, Thalidomide has been shown effective in treati
Resistance test approved.: Posit Aware. 1998 Sep-Oct;9(5):16. Unique Identifier : AIDSLINE AIDS/99704326; The FDA has approved the first phenotype test for determining HIV drug resistance. This test looks at a drug s ability to inhibit a patient s virus in a test tube. The information from this test may be used in developing a drug regimen. The test costs $880, and it takes 3 to 4 weeks t
Trials for protease failure.: Posit Aware. 1998 Sep-Oct;9(5):16-7. Unique Identifier : AIDSLINE AIDS/99704327; The AIDS Clinical Trials Group (ACTG) is preparing two trials for persons who are on a protease inhibitor regimen that has failed. ACTG 398 will use the experimental drug, amprenavir (141W94), in addition to three drugs from different anti-HIV medicat
Don't mix Sustiva with Fortovase.: Posit Aware. 1998 Sep-Oct;9(5):17. Unique Identifier : AIDSLINE AIDS/99704328; DuPont Pharmaceuticals, the manufacturer of Sustiva ( efavirenz ), is urging patients to not take this drug with Fortovase (saquinavir mesylate) due to a possible interaction that may r
Pregnancy danger.: Posit Aware. 1998 Sep-Oct;9(5):18. Unique Identifier : AIDSLINE AIDS/99704329; The Pediatric AIDS Clinical Trials Group (PACTG) has discontinued enrollment of women into four pregnancy trials that use protease inhibitors . Retrospective studies have found a high number of premature births in women receiving protease inhibitor therapy. Women rec
Oral treatment for KS.: Posit Aware. 1998 Sep-Oct;9(5):18. Unique Identifier : AIDSLINE AIDS/99704330; Ligand Pharmaceuticals is seeking approval from the FDA for Panrentin (alitretinoin) gel. This drug would be the first topical treatment for Kaposi sarcoma (KS). The drug is also being studied in capsule form for oral administration. In a recent study of 34 people treated for 15 weeks
CMV after HAART.: Posit Aware. 1998 Sep-Oct;9(5):18, 23. Unique Identifier : AIDSLINE AIDS/99704331; For some time, there has been evidence that maintenance therapy for CMV disease may be unnecessary with successful anti-HIV therapy, since CMV diseases generally occur when the T-cell count drops below 50. Some studies have been indicating that while the CMV vir
Complementary therapy.: Posit Aware. 1998 Sep-Oct;9(5):23. Unique Identifier : AIDSLINE AIDS/99704332; In developing countries with little access to antiviral therapy, there is evidence that counseling and adopting a health lifestyle may delay the progression of AIDS. In India , some doctors have reported that of 460 persons counseled on lifestyle, 85 percent had CD4 counts over 500.
Female condom use by men.: Posit Aware. 1998 Sep-Oct;9(5):23. Unique Identifier : AIDSLINE AIDS/99704333; In a survey of more than 2,200 men, a majority said they were very likely or somewhat likely to use the Reality female condom for future receptive and insertive anal intercourse. Fifty-four percent of the men surveyed actually preferred using the Reality condom to the male condom. Since the Reality condom was original
Access under managed care.: Posit Aware. 1998 Sep-Oct;9(5):23. Unique Identifier : AIDSLINE AIDS/99704334; Patients with HIV infection in New York City that are using managed care programs have reported that they are generally very satisfied with their care. However, certain groups, such as ethnic minorities, substance abusers, and people with cognitive or functional deficits, reported having more difficulty obtaining care
Reflections on Geneva.: Posit Aware. 1998 Sep-Oct;9(5):24-7. Unique Identifier : AIDSLINE AIDS/99704335; Whitson S; The 12th World AIDS Conference in Geneva revealed two very different HIV epidemics in the world, marked by vast differences in wealth and technology availability. Ninety-five percent of people living with AIDS reside in Africa and Asia where funds are scarce. India has 4 million peo
Notes on the International AIDS Conference.: Posit Aware. 1998 Sep-Oct;9(5):33-5. Unique Identifier : AIDSLINE AIDS/99704336; Levin J; National AIDS Treatment Advocacy Project, New York, NY.; At the AIDS Conference in Geneva, reports were presented on new drugs expected to improve treatment of HIV infection, to be useful in combination therapies, and to be less susceptible to viral resistance. Advances in understanding resistance to specific drugs and cross-resistance among drugs were reported. New informa
Immune reconstitution: conference reports.: Posit Aware. 1998 Sep-Oct;9(5):36-9, 41-3. Unique Identifier : AIDSLINE AIDS/99704337; Whitfield L; A report from the 12th World AIDS Conference in Geneva suggested that complete HIV eradication may not be required, because the immune system may be capable of controlling HIV. This belief is partly based on the history of a patient from Berlin who was diagnosed with HIV; began
Body composition changes with protease therapy.: Posit Aware. 1998 Sep-Oct;9(5):47. Unique Identifier : AIDSLINE AIDS/99704338; Berger D; Lipodystrophy is a metabolic phenomena that results in abnormal body composition changes. The causes of lipodystrophy, how it appears and its consequences, and possible treatments are explored. Anecdotal reports show some success in treating lipodystrophy with recombinant human growth hormone (serostim), which has bee
Pipe dreams.: Posit Aware. 1998 Sep-Oct;9(5):48-9. Unique Identifier : AIDSLINE AIDS/99704339; Whitson S; A chart is presented listing new compounds that will become available to fight HIV. The chart lists compounds according to when they are expected to be available, their classification, the drug s significance, and the manufacturer. Contact information is provided for some of the manufacturers.
Advantages of HIV treatment with Hydrea (Hydroxyurea).: Posit Aware. 1998 Sep-Oct;9(5):54. Unique Identifier : AIDSLINE AIDS/99704340; Baker B; Evidence on the efficacious use of Hydroxyurea (Hydrea) in HIV treatment is discussed. Hydroxyurea appears to work against dormant cells that other anti-HIV medications do not seem to affect. In addition, several studies have reported undetectable viral loads in the blood of patients on the Hydroxyurea/ddI combination
Hepatitis C.: Posit Aware. 1998 Sep-Oct;9(5):55. Unique Identifier : AIDSLINE AIDS/99704341; Vazquez E; The conference in Geneva addressed a number of studies concerning the impact and treatment of HIV/hepatitis C virus (HCV) co-infection. Each of these studies are highlighted. In addition, reports covered the relationship between co-infection and liver disease development, and the long term results of HAART on HCV. One
AIDS conference data on children.: Posit Aware. 1998 Sep-Oct;9(5):58-9. Unique Identifier : AIDSLINE AIDS/99704342; Vazquez E; Studies concerning HIV in children are highlighted, revealing a gap in pediatric research volume compared to research in adults, and indicating differences in how drug effects are measured between pediatric studies and adult studies. Some positive results from pediatric studies are discussed, such as how having a cesa
Large HIV vaccine trial begins.: GMHC Treat Issues. 1998 Oct;12(10):1-5. Unique Identifier : AIDSLINE AIDS/99704343; Santiago L; VaxGen has launched the first large-scale efficacy trial in the United States of a potential HIV vaccine. Five-thousand high-risk women and gay men will be recruited over a period of a year, with two out of three being randomized to receive the prev
Resistance assay update.: GMHC Treat Issues. 1998 Oct;12(10):5-7. Unique Identifier : AIDSLINE AIDS/99704344; Gilden D; Phenotypic resistance assays involve culturing the HIV virus from a patient and exposing this culture to different drugs for possible effects on the virus. The process is valuable, but results can take 4 weeks to process. One new assay by ViroLogic is undergoing quality control testing, and another by Virco and LabCor
Obstacles to treatment success.: GMHC Treat Issues. 1998 Oct;12(10):8-10. Unique Identifier : AIDSLINE AIDS/99704345; Cadman J; There are many factors related to treatment success, but two important ones are the physician s ability to prescribe drugs correctly and the patient s ability to adhere to the prescribed regimen. A national survey conducted at Johns Hopkins University and the University of California at San Francisco showed that 25 pe
A long wait for Ritonavir capsules.: GMHC Treat Issues. 1998 Oct;12(10):10-2. Unique Identifier : AIDSLINE AIDS/99704346; Cadman J; Abbott Laboratories encountered a serious manufacturing problem with its Ritonavir ( Norvir ) capsules, and officials have since announced that the
Access to efavirenz and amprenavir.: GMHC Treat Issues. 1998 Oct;12(10):12. Unique Identifier : AIDSLINE AIDS/99704347; Gilden D; DuPont s new nonnucleoside analog, efavirenz ( Sustiva ), is embroiled in a controversy related to the high costs of the drug. DuPont has offered a 5 percent discount off of the current
Abacavir's trials and tribulations.: GMHC Treat Issues. 1998 Nov;12(11):1-3. Unique Identifier : AIDSLINE AIDS/99704348; Gilden D; The FDA Antiviral Advisory Committee has recommended the approval of abacavir ( Ziagen ), a nucleoside analog that is produced by Glaxo Wellcome .
Antiviral therapy: how simple can you get?: GMHC Treat Issues. 1998 Nov;12(11):3-7. Unique Identifier : AIDSLINE AIDS/99704349; Gilden D; Efavirenz and abacavir , two recently approved drugs, have simplified HIV treatment. They are taken less often than some other drugs, and fewer pills are required. Results are reported
New CMV retinitis drug approved.: Body Posit. 1998 Oct;XI(10):10. Unique Identifier : AIDSLINE AIDS/99704350; Vitravene, a drug from Isis Pharmaceuticals , Inc. that is used to treat cytomegalovirus ( CMV ) retinitis, was recommended for approval by the Federal Drug Administration. The drug is admini
Immigration ban test.: Body Posit. 1998 Oct;XI(10):11. Unique Identifier : AIDSLINE AIDS/99704351; Engle L; The U.S. law that restricts immigration of individuals who have AIDS or other contagious diseases, has prevented Christopher Arnesen from returning to the U.S. to collect Social Security benefits that are owed to him. To be eligible for the benefits, Arnesen was supposed to reside in the U.S. for 2 months each year. H
Off label drug promotion.: Body Posit. 1998 Oct;XI(10):11. Unique Identifier : AIDSLINE AIDS/99704352; AIDS advocates have expressed concern over a Federal judge s ruling. The ruling states that the Food and Drug Administration ( FDA ) must allow pharmaceutical companies to distribute information about off-label uses for their FDA approved drugs. The advocates contend that the ruling wil
Jairo Pedraza on HIV in Latin America. [interview by Valerie Michele Hoskins]: Body Posit. 1998 Oct;XI(10):14-23. Unique Identifier : AIDSLINE AIDS/99704353; Pedraza J; Jairo Pedraza, a native of Columbia, is an AIDS activist who participates in many organizations, and who has a particular interest in the international issues surrounding HIV/AIDS. Pedraza, like the late Dr. Jonathan Mann, believes that the availability of treatment for AIDS has become an economic issue. In Latin Amer
The silence not as powerful in Sweden. [interview by Valerie Michele Hoskins]: Unique Identifier : AIDSLINE AIDS/99704354; Falkenstrom B; Bertil Falkenstrom, President of RFHP, which is an organization of support groups for Swedish people with HIV, discusses what life is like for HIV-positive individuals in Sweden . Under the Communicable Diseases Act, all doctor visits are free for Swedish citizens and residents who
Traditional healing in a modern epidemic.: Body Posit. 1998 Oct;XI(10):41-5. Unique Identifier : AIDSLINE AIDS/99704355; Engle L; Traditional and Modern Health Practitioners Together Against AIDS (THETA) is an organization that combines the approaches of traditional healers, who are culturally important to the populations that they serve, with that of modern doctors. The group was founded by members of Doctors Without Borders, and The AIDS Suppo
Starting HIV therapies: adherence conference excerpts.: Body Posit. 1998 Oct;XI(10):46-7. Unique Identifier : AIDSLINE AIDS/99704356; Marer M; Current findings regarding beginning and maintaining HIV therapies, as well as behavioral issues, are discussed. Case studies are presented by two people with AIDS who detailed their backgrounds, health status, and views about the treatment regimens that are available to them. Panelists discussed whether the positive
Care and treatment advocacy within a managed care environment.: RITA Newsl. 1998 Oct;4(6):3-4. Unique Identifier : AIDSLINE AIDS/99704357; Livesay H; Bering HIV/AIDS Advocacy Project, Houston, TX.; More people are receiving health care from managed care programs, and a number of States are shifting their Medicaid programs to managed care providers. People with HIV and AIDS have long complained that HMOs and PPOs limit their access to HIV- experienced doctors and restrict the availability of some drugs, largely d
Diagnostics: useful tools for monitoring HIV. Project Inform.: RITA Newsl. 1998 Oct;4(6):5-9. Unique Identifier : AIDSLINE AIDS/99704358; Laboratory tests are an important component of managing care for people with HIV. Blood chemistry and viral load testing should be done shortly following a HIV diagnosis to provide a baseline number for evaluating the effectiveness of subsequent treatments. Understanding the implications of the tests, however, is a da
Merck discontinues twice-daily dosing of Crixivan.: RITA Newsl. 1998 Oct;4(6):13. Unique Identifier : AIDSLINE AIDS/99704359; Merck has discontinued testing the twice-daily dosing of its protease inhibitor Crixivan ( Indinavir ) in combination with reverse transcriptase inhibitors (RTIs). Merck recommends that
FDA approves Sustiva (efavirenz) capsules, first once-daily anti-HIV drug. Food and Drug Administration.: RITA Newsl. 1998 Oct;4(6):13-4. Unique Identifier : AIDSLINE AIDS/99704360; The U.S. Food and Drug Administration ( FDA ) has approved Sustiva ( efavirenz ) as the first HIV drug to have a once-daily dosing schedule. The drug, de
Simply stated.... Project Inform.: RITA Newsl. 1998 Oct;4(6):15. Unique Identifier : AIDSLINE AIDS/99704361; Patients need to understand the results of their laboratory tests to help manage their own treatment, and it is often difficult to interpret the various numbers. The Center for AIDS Treatment has established a hotline for patients who need assistance with the test results and has provided a list of the most common tes
Hepatitis C virus (HCV): the basics.: World. 1998 Oct;(No 90):2. Unique Identifier : AIDSLINE AIDS/99704362; Hepatitis C (HCV) virus is a blood borne virus that destroys liver cells. Initial infection has lead to chronic infection in many people, and eventually chronic infection can progress to cirrhosis or liver cancer. Special diets may be necessary to maintain liver function, so consulting a dietician is recommended. Ther
When you have HIV and Hepatitis C.: World. 1998 Oct;(No 90):3-5. Unique Identifier : AIDSLINE AIDS/99704363; Tolmachoff R; Approximately 40 percent of people with HIV are believed to be co-infected with Hepatitis C virus (HCV). Each of the viruses can accelerate the progression of the other virus. Similarities between the two viruses are outlined, including how the viruses are transmitted and how they are detected. Comparisons between HIV
Where to get more information about HCV.: World. 1998 Oct;(No 90):6. Unique Identifier : AIDSLINE AIDS/99704364; A list of organizations, support groups, and websites on Hepatitis C virus (HCV) is provided. A table delineates the conditions associated with chronic HCV and provides the National Institutes of Health s recommendations for the treatment of each condition. Current clinical trials that are being conducted on co-infect
Twice-daily dosing Crixivan study discontinued.: World. 1998 Oct;(No 90):7. Unique Identifier : AIDSLINE AIDS/99704365; Merck & Co. , Inc. has suspended a study of twice-daily dosing of Crixivan ( Indinavir ) in combination with
Indinavir--study highlights importance of CD4+ counts over viral load.: Treat Update. 1998 Nov;10(9):2-3. Unique Identifier : AIDSLINE AIDS/99704366; Long-term combination therapy with protease inhibitors has often led to increased CD4+ cell counts and decreased viral loads, which can contribute to overall clinical improvement in patients. However, individual resu
Abacavir gets green light from FDA advisory board. Food and Drug Administration.: Treat Update. 1998 Nov;10(9):3-4. Unique Identifier : AIDSLINE AIDS/99704367; An advisory committee of the Food and Drug Administration ( FDA ) has recommended accelerated approval for abacavir (ABC, Ziagen ). The approval decision was not unanimous due to concerns of drug toxicity. Three percent
A boost for the immune system.: Treat Update. 1998 Nov;10(9):3-4. Unique Identifier : AIDSLINE AIDS/99704368; Protease inhibitor therapy dramatically reduces HIV viral load, however, when patients stop taking their medications, their viral load can rebound. A new product called remune (the Salk HIV vaccine) appears to enhance the immune system s response to HIV. However, since remune is a therapeutic vaccine, it cannot preven
Two immune boosters against hepatitis C.: Treat Update. 1998 Nov;10(9):4-5. Unique Identifier : AIDSLINE AIDS/99704369; Hepatitis C (HCV) can cause liver damage or liver cancer, and it is doubtful that antiviral drugs alone will be able to cure HCV. Because of the limitations of antiviral drugs, researchers are studying ways to enhance the immune system s ability to fight HCV. The current standard therapy for treating HCV is to use Int
Moving forward: a treatment overview from the 12th World AIDS Conference.: PWA Newsline. 1998 Sep;:6-11. Unique Identifier : AIDSLINE AIDS/99704370; Agosto M; National Minority AIDS Council, Washington, DC.; The 12th World AIDS Conference in Geneva brought together AIDS researchers, medical care providers, advocates, and people living with HIV to discuss implications related to providing global access to care. New drugs have decreased deaths and opportunistic infections in developed countries, but developing countries are
A chat with HIV specialists: the Geneva report.: PWA Newsline. 1998 Sep;:12-7. Unique Identifier : AIDSLINE AIDS/99704371; The Geneva conference included a panel discussion by Dr. Michael Johnson of the Health Resources and Service Administration HIV/AIDS Bureau, Dr. Steven Deeks of the University of California at San Francisco s AIDS Program, Dr. Joel Gallant of the Johns Hopkins University School of Medicine, and Dr. Gabriel Torres of t
Barebacking no more: transmission of resistant HIV strains a reality.: PWA Newsline. 1998 Sep;:18-9. Unique Identifier : AIDSLINE AIDS/99704372; Arroyo H; The progress on treating HIV with protease inhibitors is leading many in the AIDS community to believe that people are becoming complacent about practicing safer sex. There are many reports from the gay community of barebacking , or practicing unprotected receptive
Tid-bits from Geneva.: PWA Newsline. 1998 Sep;:24-6. Unique Identifier : AIDSLINE AIDS/99704373; Global access to HIV/AIDS treatment was the universal theme at the 12th World AIDS Conference. However, 90 percent of people with AIDS do not have access to available therapy. Special attention is needed in dealing with HIV infected persons who are incarcerated and do not have access to the same level of care as the r
African Americans, women & children: reasons for hope from the Geneva conference.: PWA Newsline. 1998 Sep;:27-30. Unique Identifier : AIDSLINE AIDS/99704374; A radio broadcast hosted by Hope Daniels and Chris DeChant discussed the relevance of the Geneva conference to the lives of African Americans, women, and children. AIDS is the leading cause of death among African Americans between the ages of 25 and 44. They also represent 57 percent of all new cases diagnosed. In add
AIDS toll reaches 11.7 million.: PWA Newsline. 1998 Sep;:31-2. Unique Identifier : AIDSLINE AIDS/99704375; Since it was first identified in 1981, the cumulative death toll from HIV/AIDS has reached 11.7 million. Statistics are provided which show that an estimated 30.6 million people currently have the disease, with 16,000 new infections occurring daily. WHO estimates that the number of infected individuals will be 40 mill
Any toxic relief in sight? The induction/maintenance approach to therapy.: PWA Newsline. 1998 Sep;:33. Unique Identifier : AIDSLINE AIDS/99704376; Gomez E; Induction/maintenance drug therapy is being tested as an alternative to sustained HIV treatment with highly toxic antiretrovirals. Induction/maintenance therapy is the primary method in which cancer patients receive chemotherapy, and it involves high doses of drugs followed by lower maintenance doses. In the case of H
Wasting and body changes: what do we know so far?: PWA Newsline. 1998 Sep;:34-6. Unique Identifier : AIDSLINE AIDS/99704377; Gomez E; A satellite symposium was held at the 12th World AIDS Conference to address issues related to wasting, metabolic changes, and altered body shapes in persons with HIV/AIDS. Wasting, which is defined as severe weight loss, is a serious problem for people with HIV, who can lose an average of 20 percent of their body weig
The new body of AIDS: Crixivan bellies, legs, and humps.: PWA Newsline. 1998 Sep;:37-9. Unique Identifier : AIDSLINE AIDS/99704378; McCabe L; Use of the commonly prescribed protease inhibitor Crixivan appears to result in a bizarre adverse effect, despite its desirable effects on T-cell count and viral load. This adverse effect is more common in women than men, and includes the following sy
AIDS law: settlement reached in Knox v. Turner.: PWA Newsline. 1998 Sep;:48. Unique Identifier : AIDSLINE AIDS/99704379; A settlement has been reached in Knox v. Turner, a case brought against the Human Resources Administration (HRA) by five individuals with HIV-related diseases and by City AIDS Actions. The group filed suit to force HRA to notify HIV rent enhancement recipients of their eligibility for Division of AIDS Services and Inc
New strain of AIDS virus discovered in Africa.: PWA Newsline. 1998 Sep;:49. Unique Identifier : AIDSLINE AIDS/99704380; French researchers have discovered a rare HIV strain that can avoid detection with standard tests. The strain was found in a Cameroon woman, and three additional cases from Cameroon were identified later. The strain is related to both common HIV and SIV strains. The HIV variant d
Abbott's liquid Ritonavir - get used to it.: PWA Newsline. 1998 Sep;:50. Unique Identifier : AIDSLINE AIDS/99704381; Abbott Laboratories is experiencing manufacturing problems with the capsule formulation of Norvir ( Ritonavir ) and is recommending that all patien
AIDS research leader lost on SwissAir Flight 111.: PWA Newsline. 1998 Sep;:52. Unique Identifier : AIDSLINE AIDS/99704382; Sawyer E; Dr. Jonathan Mann and his wife, Mary-Lou Clements-Mann, were killed in the crash of SwissAir Flight 111. Dr. Mann was one of the world s foremost authorities on global AIDS and was the architect of the World Health Organization s Global Programme on AIDS. He also co-wrote two books defining and analyzing the global ep
Interleukin-2 clinical trials.: PWA Newsline. 1998 Sep;:58. Unique Identifier : AIDSLINE AIDS/99704383; Patient selection criteria are presented for three clinical trials using low-dose Interleukin-2 ( IL-2 ) to reconstitute the immune system in HIV-infected patients. These trials are being conducted by the New York Presbyterian Hospital-Cornell Medical Center. In addition
CRIA clinical trials.: PWA Newsline. 1998 Sep;:59. Unique Identifier : AIDSLINE AIDS/99704384; The Community Research Initiative on AIDS is currently screening potential volunteers for clinical trials. Current studies include the effects of protease inhibitors on blood sugar, the effectiveness of twice a day
Circulating interferon-gamma- and interleukin-4-secreting cells in recurrent spontaneous abortions.: Am J Reprod Immunol. 1999 Apr;41(4):257-63. Unique Identifier : AIDSLINE MED/99301238; Palfi M; Jablonowska B; Matthiesen L; Ernerudh J; Department of Transfusion Medicine and Clinical Immunology,; Institution of Health and Environment, Faculty of Health; Sciences, Linkoping University, Sweden.; PROBLEM: Are recurrent spontaneous abortions (RSAs) associated with deviation of circulating cytokine-secreting cells? METHOD OF STUDY: Interferon (IFN)-gamma- and interleukin (IL)-4 secreting cells were identified by enzyme-linked immunospot (ELISPOT) in blood from 34 women with RSA. Samples were taken before pregnan
Development of a bioconversion process for production of cis-1S,2R-indandiol from indene by recombinant Escherichia coli constructs.: Appl Microbiol Biotechnol. 1999 May;51(5):614-20. Unique Identifier : AIDSLINE MED/99319292; Reddy J; Lee C; Neeper M; Greasham R; Zhang J; Bioprocess R&D, Merck & Co. Inc., Rahway, NJ 07065, USA.; Recombinant Escherichia coli cells expressing the toluene dioxygenase (TDO) genes from Pseudomonas putida convert indene to cis-1S,2R-indandiol, a potentially important intermediate for the chemical synthesis of the HIV-1 protease inhibitor, Crixivan .
No association of HIV type 1 long terminal repeat sequence pattern with long-term nonprogression and in vivo viral replication levels in European subjects.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):609-17. Unique Identifier : AIDSLINE +; Visco-Comandini U; Yun Z; Vahlne A; Sonnerborg A; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institutet, Huddinge, Sweden.; viscocomandini@mclink.it; The HIV-1 long terminal repeat (LTR) promotes and modulates proviral transcription in the infected cell. It has been suggested that truncations and even point mutations in functional sites of the LTR are associated with low viral replication and attenuated pathogenesis in HIV-1-infected long-term nonprogressors (LTNPs
Immune restoration by combination of a cytostatic drug (hydroxyurea) and anti-HIV drugs (didanosine and indinavir).: AIDS Res Hum Retroviruses. 1999 May 1;15(7):619-24. Unique Identifier : AIDSLINE MED/99260283; Lori F; Jessen H; Lieberman J; Clerici M; Tinelli C; Lisziewicz J; Research Institute for Genetic and Human Therapy, Washington, DC; 20007, USA.; Cell activation is essential for HIV infection. CD4+ T lymphocyte activation allows virus replication and CD8+ T lymphocyte activation may contribute to pathogenesis. We combined hydroxyurea, a cytostatic drug that inhibits cell activation and proliferation, with two drugs that inhibit HIV (didanosine and
Risk factors for cryptococcal meningitis in HIV-infected patients.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):625-31. Unique Identifier : AIDSLINE MED/99260284; Oursler KA; Moore RD; Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21287-0003, USA.; To identify the risk factors for cryptococcal meningitis in patients with HIV disease we conducted a nested case-control study of 37 incident cases of cryptococcal meningitis and 74 controls, identified from a cohort of more than 2000 HIV-infected patients. Conditional logistic regression was used to study demographic
Safety and immunogenicity of a live recombinant canarypox virus expressing HIV type 1 gp120 MN MN tm/gag/protease LAI (ALVAC-HIV, vCP205) followed by a p24E-V3 MN synthetic peptide (CLTB-36) administered in healthy volunteers at low risk for HIV infection. AGIS Group and L'Agence Nationale de Recherches sur Le Sida.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):633-45. Unique Identifier : AIDSLINE MED/99260285; Salmon-Ceron D; Excler JL; Finkielsztejn L; Autran B; Gluckman JC; Sicard D; Matthews TJ; Meignier B; Valentin C; El Habib R; Blondeau C; Raux M; Moog C; Tartaglia J; Chong P; Klein M; Milcamps B; Heshmati F; Plotkin S; CHU Cochin AP HP, Universite Paris, France.; A live recombinant canarypox vector expressing HIV-1 gpl20 MN tm/gag/protease LAI (ALVAC-HIV, vCP205) alone or boosted by a p24E-V3 MN synthetic peptide (CLTB-36) was tested in healthy volunteers at low risk for HIV infection for their safety and immunogenicity. Both antigens were well tolerated. ALVAC-HIV (vCP205) in
Phenotypic characteristics of human immunodeficiency virus type 1 subtype C isolates of Ethiopian AIDS patients.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):647-53. Unique Identifier : AIDSLINE MED/99260286; Bjorndal A; Sonnerborg A; Tscherning C; Albert J; Fenyo EM; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden. Asa.Bjorndal@mtc.ki.se; It has been estimated that, to date, about 48% of all HIV-infected people in the world carry HIV-1 subtype C virus. Therefore, it is of great importance to gain better knowledge about the genetic and biological characteristics of this virus subtype. In the present study, the biological properties of HIV-1 isolates obt
Genetic heterogeneity of HIV type 1 subtypes in Kimpese, rural Democratic Republic of Congo.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):655-64. Unique Identifier : AIDSLINE MED/99260287; Mokili JL; Wade CM; Burns SM; Cutting WA; Bopopi JM; Green SD; Peutherer JF; Simmonds P; Department of Medical Microbiology, University of Edinburgh, UK.; Jmokili@hiv.hif.org; A relatively low and stable seroprevalence of HIV-1 was previously reported among pregnant women attending for antenatal care between 1988 and 1993 in Kimpese, a rural town in the Democratic Republic of Congo (DRC, formerly Zaire ). To characterize the HIV-1 subtypes circulating in
CD8+ lymphocytes in pregnancy and HIV infection: characterization of CD8+ subpopulations and CD8+ noncytotoxic antiviral activity.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):665-70. Unique Identifier : AIDSLINE MED/99260288; Rich KC; Siegel JN; Jennings C; Rydman RJ; Landay AL; Department of Pediatrics, University of Illinois at Chicago,; 60612, USA.; The distribution and function of lymphocytes vary in different clinical states. The object of this study was to characterize the CD8+ lymphocyte subpopulations and CD8+ anti-HIV suppressor activity in HIV-infected and uninfected pregnant and nonpregnant women. The total percentage of CD8+ lymphocytes was not altered b
Human immunodeficiency virus V3 peptide-reactive antibodies are present in normal HIV-negative sera.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):671-7. Unique Identifier : AIDSLINE MED/99260289; Metlas R; Trajkovic D; Srdic T; Veljkovic V; Colombatti A; R&D Division, Diapharm, Belgrade, Yugoslavia.; A structural relation between consensus sequences of the portion of HIV-1 gp120 involving the V3 loop (V3 peptide) and the variable domains of human immunoglobulin members of the VH-III gene family was proposed to trigger an imbalance of the idiotypic network during the course of HIV infection. Thus, the repertoires o
HIV type 1 sequences with GGC substitution in injecting drug users in Greece.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):679-80. Unique Identifier : AIDSLINE GENBANK/AF094530; Adwan G; Papa A; Kouidou S; Alexiou S; Malissiovas N; Ntoutsos I; Kiosses B; Antoniadis A; Department of Microbiology, School of Medicine, Aristotelian; University of Thessaloniki, Greece.
Characterization of V3 loop sequences from HIV type 1 subtype B in South Korea: predominance of the GPGS motif.: AIDS Res Hum Retroviruses. 1999 May 1;15(7):681-6. Unique Identifier : AIDSLINE GENBANK/K03455; Kim EY; Cho YS; Maeng SH; Kang C; Nam JG; Lee JS; Center for AIDS Research, National Institute of Health, Seoul,; South Korea.
HIV type 2 can bind to CD8 molecules but does not infect CD8+ T cells [letter]: AIDS Res Hum Retroviruses. 1999 May 1;15(7):687-8. Unique Identifier : AIDSLINE MED/99260292; Ichiyama K; Akimoto H; Neoh LP; Takeda-Hirokawa N; Kaneko H; Hishikawa T; Hashimoto H; Hirose S; Kaneko Y; Yamamoto N; Sekigawa I
Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: II. Regulation by tumour necrosis factor-alpha.: Cell Signal. 1999 May;11(5):371-83. Unique Identifier : AIDSLINE MED/99303304; Watanabe K; Kazakova I; Furniss M; Miller SC; Signal Transduction Laboratory, Pharmaceutical Discovery; Division, SRI International, Menlo Park, CA 94025, USA.; In the human promonocytic U937 cell line, pyrrolidine dithiocarbamate (PDTC) was a potent inhibitor of the nuclear factor-kappaB (NF-kappaB) signalling pathway induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). However, PDTC did not inhibit tumour necrosis factor-alpha (TNF-alpha)-induced NF-kapp
The oncogenic 30 and 69 bp deletion variants of the EBV LMP-1 gene are common in HIV-negative lymphoproliferations, both malignant and benign.: Ann Oncol. 1999 Apr;10(4):467-9. Unique Identifier : AIDSLINE MED/99298929; Barozzi P; Luppi M; Cagossi K; Maiorana A; Marasca R; Artusi T; Poggi S; Pileri SA; Torelli G; Department of Medical Sciences, University of Modena, Italy.; BACKGROUND: In vitro studies have shown that the 30 and 69 base pair (bp) deletion variants of the latent membrane protein (LMP)-1 gene of the Epstein-Barr virus (EBV) have a higher transforming capacity than the wild-type variant. In recent years these studies have triggered an in vivo search for such potentially onc
Th1-derived cytokine IFN-gamma is a potent inhibitor of eotaxin synthesis in vitro.: Int Immunol. 1999 Jun;11(6):1001-4. Unique Identifier : AIDSLINE MED/99289381; Miyamasu M; Yamaguchi M; Nakajima T; Misaki Y; Morita Y; Matsushima K; Yamamoto K; Hirai K; Department of Allergy and Rheumatology, CREST, University of; Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo; 113-8655, Japan.; Eotaxin potentially plays an integral role in tissue eosinophilia. Inasmuch as Th2-derived cytokine IL-4 has been shown to stimulate eotaxin generation, we investigated here the effect of Th1-derived cytokine IFN-gamma on human eotaxin production. IFN-gamma but not -alpha or -beta potently inhibited tumor necrosis fac
Expansion of neonatal tolerance to self in adult life: I. The role of a bacterial adjuvant in tolerance spread.: Int Immunol. 1999 Jun;11(6):899-906. Unique Identifier : AIDSLINE MED/99289369; Grabie N; Wohl I; Youssef S; Wildbaum G; Karin N; Department of Immunology, Bruce Rappaport Faculty of Medicine and; Rappaport Family Institute for Research in the Medical Sciences,; Technion, POB 9697, Haifa 31096, Israel.; T cell neonatal tolerance to self evolves perturbation of the Th1/Th2 balance towards Th2-type self-specific T cells. In the current study we have demonstrated that a tolerant state could be extended to another encephalitogenic determinant only if the neonatally tolerizing determinant was co-administered in adult life
Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide.: Int Immunol. 1999 Jun;11(6):957-66. Unique Identifier : AIDSLINE MED/99289376; Elias D; Tikochinski Y; Frankel G; Cohen IR; Department of Immunology, The Weizmann Institute of Science,; Rehovot 76100, Israel.; NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i
[CMV retinitis--"the lightning that announces a storm"]: Oftalmologia. 1998;45(4):14-20. Unique Identifier : AIDSLINE MED/99347177; Gafencu O; Carstocea B; Ionita M; Spitalul Militar Central, Clinica de Oftalmologie.; After a theoretic presentation, the authors show the results of a study on 11 patients with cytomegalovirus retinitis. We observed the slowing of the evolution of the retinal lesions. Of 11 patients, 8 comes the first time to the physician for ocular symptoms. The
Origins and evolution of AIDS viruses.: Biol Bull. 1999 Jun;196(3):338-42. Unique Identifier : AIDSLINE MED/99319306; Sharp PM; Bailes E; Robertson DL; Gao F; Hahn BH; Institute of Genetics, University of Nottingham, Queens Medical; Centre, UK.
Characterization of immune responses caused by bovine leukemia virus envelope peptides in sheep.: J Vet Med Sci. 1999 May;61(5):475-80. Unique Identifier : AIDSLINE MED/99306605; Kabeya H; Ohashi K; Sugimoto C; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Sapporo, Japan.; To study the immunomodulative activity caused by bovine leukemia virus envelope (BLV Env) peptide, sheep were immunized with two kinds of Th-epitope peptides, peptide 98 (BLV Env 98-117), and 61 (BLV Env 61-78). Four of eight immunized sheep showed specific proliferative responses against both of the peptide stimulati
Seroprevalence of bovine immunodeficiency virus in dairy and beef cattle herds in Korea.: J Vet Med Sci. 1999 May;61(5):549-51. Unique Identifier : AIDSLINE MED/99306617; Cho KO; Meas S; Park NY; Kim YH; Lim YK; Endoh D; Lee SI; Ohashi K; Sugimoto C; Onuma M; Laboratories of Infectious Diseases, Graduate School of; Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Infection of bovine immunodeficiency virus (BIV), a lentivirus, is thought to sporadically occur throughout the world, but seroepidemiological surveys concerning the incidence of BIV are limited and have not been undertaken in Korea. A total of 266 sera from different twenty dairy (Holstein) and twenty-six Korean nati
Antiretroviral antibodies: implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder.: Biol Psychiatry. 1999 Mar 15;45(6):704-14. Unique Identifier : AIDSLINE MED/99203815; Hart DJ; Heath RG; Sautter FJ Jr; Schwartz BD; Garry RF; Choi B; Beilke MA; Hart LK; Department of Psychiatry and Neurology, Tulane University School; of Medicine, New Orleans, Louisiana 70112, USA.; BACKGROUND: Some retroviral antigens share structural homology within a group of related retroviruses. It is possible that antibodies directed against one virus may cross-react with antigens from a different virus in the group. METHODS: Using this principle, the human immunodeficiency virus 1 (HIV-1) Western blot assa
Interferon gamma, IL2, IL4, IL10 and TNFalpha secretions in multiple sclerosis patients treated with an anti-CD4 monoclonal antibody.: Autoimmunity. 1999;29(2):87-92. Unique Identifier : AIDSLINE MED/99360451; Lopez E; Racadot E; Bataillard M; Berger E; Rumbach L; Etablissement de Transfusion Sanguine, Besancon, France.; In order to better understand the mechanisms of action of a monoclonal anti-CD4/BF5 antibody(mAb), cytokine secretions were studied in 14 multiple sclerosis (MS) patients treated in a phase 1 trial. Secretion patterns of IFNgamma, IL2, IL4, IL10 and TNFalpha by peripheral blood mononuclear cells were studied before (D
[The clinico-epidemiological characteristics of HIV infection in 93 adults in the Republic of Moldova]: Bacteriol Virusol Parazitol Epidemiol. 1998 Oct-Dec;43(4):269-74. Unique Identifier : AIDSLINE MED/99351223; Cojocaru S; Cojocaru R; U.M.F. Carol Davila, Bucuresti.; We have examined 93 adults HIV serum-positive (citizens of Moldova Republic), admitted in 1994-1998 (months I-VIII) to the Hospital of Infections Diseases T. Ciorba --Kishinev. Since 1996 the number of HIV infected people began to
Postantibiotic effects of rifampin, amikacin, clarithromycin and ethambutol used alone or in various two-, three- and four-drug combinations against Mycobacterium avium.: FEMS Immunol Med Microbiol. 1999 Jan;23(1):37-44. Unique Identifier : AIDSLINE MED/99153616; Horgen L; Legrand E; Rastogi N; Unite de la Tuberculose et des Mycobacteries, Institut Pasteur,; Mome Joliviere, Pointe a Pitre, Guadeloupe.; The postantibiotic effects (PAEs) of rifampin, amikacin, clarithromycin, and ethambutol were determined radiometrically against five AIDS-associated isolates of Mycobacterium avium. and were found to be 20.8+/-3.4. 18.4+/-2.5, 11.8+/-1.7. and 2.4+/-0.9 h, respectively. Various two-, three- or four-drug combinations we
Antibodies to cardiolipin and beta2-glycoprotein-1 in HTLV-1-associated myelopathy/tropical spastic paraparesis.: Lupus. 1999;8(3):210-4. Unique Identifier : AIDSLINE MED/99272141; Faghiri Z; Wilson WA; Taheri F; Barton EN; Morgan OS; Gharavi AE; Department of Medicine, Louisiana State University Medical; Center, New Orleans 70112-2822, USA.; Anticardiolipin and anti-beta2GP1 antibodies were measured in 50 patients with HTLV-1-associated Myelopathy-Tropical Spastic Paraparesis (HAM-TSP) and the results were compared with those obtained for 34 HTLV-1-positive and 35 HTLV-1-negative controls, as well as 128 SLE patients. aCL but not anti-beta2GP1 was associa
Applications of multiple imputation in medical studies: from AIDS to NHANES.: Stat Methods Med Res. 1999 Mar;8(1):17-36. Unique Identifier : AIDSLINE MED/99277206; Barnard J; Meng XL; Department of Statistics, Harvard University, Massachusetts, USA.; Rubin s multiple imputation is a three-step method for handling complex missing data, or more generally, incomplete-data problems, which arise frequently in medical studies. At the first step, m (> 1) completed-data sets are created by imputing the unobserved data m times using m independent draws from an imputation m
The impact of HIV infection on Mycobacterium kansasii disease in South African gold miners.: Am J Respir Crit Care Med. 1999 Jul;160(1):10-4. Unique Identifier : AIDSLINE MED/99322244; Corbett EL; Churchyard GJ; Hay M; Herselman P; Clayton T; Williams B; Hayes R; Mulder D; De Cock KM; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, London, United Kingdom.; liz@pegasus.marques.co.za; The impact of human immunodeficiency virus (HIV) infection on Mycobacterium kansasii disease in miners was investigated with a retrospective study covering a single workforce. M. kansasii, isolated from 43 HIV-positive and 202 HIV-negative miners, was the most common nontuberculous mycobacterial (NTM) species in both
Nontuberculous mycobacteria: defining disease in a prospective cohort of South African miners.: Am J Respir Crit Care Med. 1999 Jul;160(1):15-21. Unique Identifier : AIDSLINE MED/99322245; Corbett EL; Blumberg L; Churchyard GJ; Moloi N; Mallory K; Clayton T; Williams BG; Chaisson RE; Hayes RJ; De Cock KM; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, London, United Kingdom.; A gold mining work force was followed prospectively over 1 yr for sputum nontuberculous mycobacterial (NTM) isolates. NTM were isolated from 118 men, of whom 32 (27%) met the American Thoracic Society (ATS) case-definitions for pulmonary NTM disease (23 M. kansasii, seven M. scrofulaceum, one M. avium, and one M. absc
Tuberculosis prevention in methadone maintenance clinics. Effectiveness and cost-effectiveness.: Am J Respir Crit Care Med. 1999 Jul;160(1):178-85. Unique Identifier : AIDSLINE MED/99322268; Snyder DC; Paz EA; Mohle-Boetani JC; Fallstad R; Black RL; Chin DP; California Department of Health Services, Tuberculosis Control; Branch, Francis J. Curray National Tuberculois Center, San; Francisco, CA, USA.; To determine the effectiveness and cost-effectiveness of a program to provide screening for tuberculosis infection and directly observed preventive therapy (DOPT) in methadone maintenance clinics, we determined completion rates of screening for tuberculosis infection, medical evaluation, and preventive therapy, as wel
The pathophysiology of pulmonary diffusion impairment in human immunodeficiency virus infection.: Am J Respir Crit Care Med. 1999 Jul;160(1):272-7. Unique Identifier : AIDSLINE MED/99322282; Diaz PT; King MA; Pacht ER; Wewers MD; Gadek JE; Neal D; Nagaraja HN; Drake J; Clanton TL; Departments of Radiology, Statistics, and Internal Medicine; (Pulmonary-Critical Division), The Ohio State University,; Columbus, Ohio, USA. Diaz-1@medctr.osu.edu; Numerous reports have demonstrated that prior to the development of acquired immunodeficiency syndrome (AIDS)-related pulmonary complications, human immunodeficiency virus-positive (HIV+) individuals commonly develop unexplained reductions in pulmonary diffusing capacity (DLCO). The potential relevance of this observa
Lymphoid disorders associated with HHV-8/KSHV infection: facts and contentions.: Med Oncol. 1999 Apr;16(1):8-12. Unique Identifier : AIDSLINE MED/99310309; Gaidano G; Castanos-Velez E; Biberfeld P; Department of Medical Sciences, Amedeo Avogadro University of; Eastern Piedmont, Novarra, Italy.; Following the demonstration in 1994, that Kaposi s sarcoma (KS) was associated with a novel virus (KSHV or HHV-8) belonging to the lymphotropic herpes family, this virus was also found in certain lymphoid neoplasias of immunodeficient (HIV+) and immune competent hosts. The association of HHV-8/KSHV infection is now we
Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4.: Transpl Immunol. 1999 Mar;7(1):65-72. Unique Identifier : AIDSLINE MED/99301616; Suzuki J; Isobe M; Izawa A; Takahashi W; Yamazaki S; Okubo Y; Amano J; Sekiguchi M; Department of Internal Medicine I, Shinshu University School of; Medicine, Matsumoto, Nagano, Japan.; Administration of anti-intercellular adhesion molecule (ICAM)-1 monoclonal antibody (mAb) plus anti-lymphocyte function associated antigen (LFA)-1 mAb induces tolerance in murine cardiac transplantation, while anti-vascular cell adhesion molecule (VCAM)-1 mAb plus anti-very late antigen (VLA)-4 mAb administration prol
Acute in vivo neurotoxicity of peptides from Maedi Visna virus transactivating protein Tat.: Brain Res. 1999 Jun 5;830(2):285-91. Unique Identifier : AIDSLINE MED/99296416; Starling I; Wright A; Arbuthnott G; Harkiss G; Division of Biomolecular Sciences, GKT Medical School, King's; College London, Guy's Campus, St. Thomas Street, London SE1 9RT,; UK.; Lentiviruses such as Maedi Visna virus (MVV) in sheep, and human immunodeficiency virus (HIV) in man often cause a variety of neurological syndromes in later stages of infection. Neuropathological investigations reveal damage to myelin and astrocytosis in both white and grey matter. MVV infection induces axonal damage
Amprenavir approved for HIV treatment [news]: Am J Health Syst Pharm. 1999 Jun 1;56(11):1057-8. Unique Identifier : AIDSLINE MED/99312177; Miller SL
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.: Immunity. 1999 Jul;11(1):45-56. Unique Identifier : AIDSLINE MED/99361931; Ding YH; Baker BM; Garboczi DN; Biddison WE; Wiley DC; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, Massachusetts 02138, USA.; The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography. The three peptide/MHC ligands include weak agonists and antagonists with differen
Polarized TH1 responses by liposome-entrapped allergen and its potential in immunotherapy of allergic disorders.: Clin Exp Allergy. 1998 Dec;28(12):1530-7. Unique Identifier : AIDSLINE MED/99146830; Sehra S; Chugh L; Gangal SV; Centre for Biochemical Technology, Delhi, India.; BACKGROUND: The conventional immunotherapy used for treating allergic individuals may at times lead to varying degrees of anaphylactic reaction. Liposomes have been proposed as a vehicle for safe and effective allergen-specific immunotherapy as multiple injections of liposome-entrapped allergen (LEA) have been shown t
Needle-stick injuries and HIV infection [editorial]: Can J Ophthalmol. 1999 Jun;34(4):189-90. Unique Identifier : AIDSLINE MED/99324975; Hurwitz JJ
Needle-stick injuries and HIV infection: a surgeon's personal experience and review of postexposure prophylaxis. St. Paul's Ocular AIDS Group.: Can J Ophthalmol. 1999 Jun;34(4):195-203. Unique Identifier : AIDSLINE MED/99324977; Hurwitz JJ; Fine N; Rachlis AR; Department of Ophthalmology, Mount Sinai Hospital, Toronto, Ont.
Corneal endothelial deposits in patients with HIV infection or AIDS: epidemiologic evidence of the contribution of rifabutin.: Can J Ophthalmol. 1999 Jun;34(4):204-9. Unique Identifier : AIDSLINE MED/99324978; Holland SP; Chang CW; Vagh M; Courtright P; British Columbia Centre for Epidemiologic and International; Ophthalmology, Department of Ophthalmology, University of British; Columbia, St. Paul's Hospital, Vancouver, BC.; BACKGROUND: We noted a number of patients with unusual fine, stellate corneal endothelial deposits. The distribution of the deposits appeared to be concentric, involving mostly the periphery. We postulated that the changes might be related to the use of rifabutin rather than to cytomeg
Sexual behaviour of commercial sex workers and their clients in Cambodia. Japan-Cambodia Collaborating Research Group.: J Epidemiol. 1999 Jun;9(3):175-82. Unique Identifier : AIDSLINE MED/99340747; Morio S; Soda K; Tajima K; Leng HB; Kitamura K; Mizushima S; Ohshige K; Tan F; Suyama A; Sopheab H; Phalla T; Kochi Prefectural Tosa-shimizu Health Center, Japan.; OBJECTIVE: This study surveyed the sexual behaviour of commercial sex workers and their clients in an attempt to identify factors of transmission of STDs (including HIV/AIDS) and to control their epidemics in Cambodia and South-East Asia. DESIGN: Cross-sectional study. SETTING: T
Efficacy of repeated cycles of chemo-immunotherapy with thymosin alpha1 and interleukin-2 after intraperitoneal 5-fluorouracil delivery.: Cancer Immunol Immunother. 1999 Jul;48(4):172-8. Unique Identifier : AIDSLINE MED/99358633; Silecchia G; Guarino E; Sinibaldi-Vallebona P; Pierimarchi P; Restuccia A; Spaziani E; Bernard P; Tuthill C; Garaci E; Rasi G; VII Patologia Chirurgica, Universita La Sapienza, Roma, Italy.; We have used chemo-immunotherapy with 5-fluorouracil (5-FU), thymosin alpha1 (T alpha1) and interleukin-2 ( IL-2 ) to treat multiple liver metastases from colorectal cancer induced by DHD/K12 cells in syngeneic BDIX rats, comparing one and two cycles of treatment, and di
Tuberculosis: 8. The disease in association with HIV infection.: CMAJ. 1999 Jul 13;161(1):47-51. Unique Identifier : AIDSLINE MED/99349351; FitzGerald JM; Houston S; Department of Medicine, University of British Columbia.; markf@interchange.ubc.ca
A line in the sand.: CMAJ. 1999 Jul 13;161(1):63-4. Unique Identifier : AIDSLINE MED/99349354; Chun R; Department of Anaesthesia, University of Toronto.
Field-based similarity forcing in energy minimization and molecular matching.: Pac Symp Biocomput. 1999;:415-25. Unique Identifier : AIDSLINE MED/99309313; Blinn JR; Rohrer DC; Maggiora GM; Pharmacia & Upjohn, Kalamazoo, MI 49007, USA.; A new field-based similarity forcing procedure for matching conformationally-flexible molecules is presented. The method extends earlier work on similarity matching of molecules based upon the program MIMIC, by directly coupling a similarity function to a molecular mechanics force field. In this way conformational ene
Growth characteristics of T-cell tropic HIV-1 vpu gene mutants in human peripheral blood mononuclear cells.: J Med Invest. 1999 Feb;46(1-2):43-7. Unique Identifier : AIDSLINE MED/99336499; Iida S; Fukumori T; Oshima Y; Koyama AH; Adachi A; Department of Virology, University of Tokushima School of; Medicine, Japan.; A mutant designated NL-E65, which lacks the expression of entire vpu gene, was constructed from T-cell tropic wild-type (wt) human immunodeficiency virus type 1 (HIV-1) clone and monitored for its replication property in human cells, along with a mutant NL-Ss which expresses a C-terminal truncated Vpu. The mutant NL-S
[Clinical and histopathological characterization of oral leukoplakia in patients with HIV infection]: Mund Kiefer Gesichtschir. 1999 Mar;3(2):73-7. Unique Identifier : AIDSLINE MED/99251264; Schmidt-Westhausen AM; Reichart PA; Gross U; The aim of this study was to assess the prevalence of oral leukoplakia (OL) in HIV-positive patients and to evaluate the clinical and histopathological features and the presence of Candida hyphae and viral infections (HSV 1, 2, HPV, EBV and CMV ) by immunocytoche
The role of traditional healers in the fight against AIDS in Africa.: J Altern Complement Med. 1999 Jun;5(3):225-8. Unique Identifier : AIDSLINE MED/99308975; Wootton JC; Alternative Medicine Foundation, Bethesda, Maryland 20814, USA.; jcw@amfoundation.org
Lack of variation in alphaGal expression on lymphocytes in miniature swine of different genotypes.: Xenotransplantation. 1999 Feb;6(1):43-51. Unique Identifier : AIDSLINE MED/99281863; Chae SJ; Kramer AD; Zhao Y; Arn S; Cooper DK; Sachs DH; Transplantation Biology Research Center, Massachusetts General; Hospital/Harvard Medical School, Boston 02129, USA.; BACKGROUND: Gal(alpha)1-3Gal epitopes (alphaGal) have been demonstrated to be present on tissues of all pig breeds tested to-date and are the major target for human anti-(alpha)galactosyl (alphaGal) antibodies. We investigated members of an MHC-inbred miniature swine herd to assess whether there was an association bet
Deaths: final data for 1997.: Natl Vital Stat Rep. 1999 Jun 30;47(19):1-104. Unique Identifier : AIDSLINE MED/99338725; Hoyert DL; Kochanek KD; Murphy SL; OBJECTIVES: This report presents final 1997 data on U.S. deaths and death rates according to demographic and medical characteristics such as age, sex, race, Hispanic origin, marital status, educational attainment, injury at work, State of residence, and cause of death. Trends and patterns in general mortality, life ex
Argentine plant extracts active against polymerase and ribonuclease H activities of HIV-1 reverse transcriptase.: Phytother Res. 1999 May;13(3):206-9. Unique Identifier : AIDSLINE MED/99281424; Hnatyszyn O; Broussalis A; Herrera G; Muschietti L; Coussio J; Martino V; Ferraro G; Font M; Monge A; Martinez-Irujo JJ; Sanroman M; Cuevas MT; Santiago E; Lasarte JJ; IQUIMEFA (Instituto de Quimica y Metabolismo del Farmaco); UBA-CONICET, Catedra de Farmacognosia, Facultad de Farmacia y; Bioquimica, Buenos Aires, Republica Argentina.; Lipophilic and hydrophilic extracts of four Argentine plants (Gamochaeta simplicaulis Cabr. 1, Achyrocline flaccida Wein. D. C. 2, Eupatorium buniifolium H. et A. 3, and Phyllanthus sellowianus Muell. Arg. 4) were examined in vitro for their ability to inhibit the polymerase and ribonuclease H (RNase H) activities of
Antiviral properties of a crude extract from a green alga Caulerpa taxifolia (Vahl) C. Agardh.: Phytother Res. 1999 May;13(3):245-7. Unique Identifier : AIDSLINE MED/99281436; Nicoletti E; Della Pieta F; Calderone V; Bandecchi P; Pistello M; Morelli I; Cinelli F; Dipartimento di Biomedicina, Centro Retrovirus sezione di; Virologia, Universita degli Studi di Pisa, Italy.; A crude extract of Caulerpa taxifolia was tested for its antiviral activity. The chloroform-methanol residue showed an interesting inhibitor effect in vitro toward the feline immunodeficiency virus (FIV), a valid model for studying the acquired immunodeficiency syndrome. This extract reduced the virus-induced syncytia
Frequency of the CCR5 gene 32-basepair deletion in Hispanic Mexicans.: Clin Exp Dermatol. 1999 Mar;24(2):127-9. Unique Identifier : AIDSLINE MED/99330617; Salas-Alanis JC; Mellerio JE; Ashton GH; McGrath JA; Servicios Medicos de la Universidad Autonoma de Nuevo Leon,; Monterrey, Mexico.; A 32-basepair deletion polymorphism in the CCR5 chemokine receptor gene (DeltaCCR5) has recently been identified and shown to have functional significance in determining susceptibility to infection by human immunodeficiency virus type 1 (HIV-1) and a possible influence on disease progression in HIV-1-positive individu
Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):259-65. Unique Identifier : AIDSLINE MED/99355056; Louisirirotchanakul S; Beddows S; Cheingsong R; Shaffer N; Mastro TD; Likanonsakul S; Wasi C; Taylor GP; Weber JN; Department of Genito-Urinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St Mary's, London, UK.; The significance of the maternal humoral immune response in relation to vertical transmission of HIV-1 was investigated in 123 mothers infected with subtype E from Thailand . Antibody binding titers to HIV-1 env domains (monomeric gp120, the CD4/gp120 binding site [BS], V3 loop, a
Anti-V3 and anti-IgG antibodies of healthy individuals share complementarity structures.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):266-70. Unique Identifier : AIDSLINE MED/99355057; Metlas R; Trajkovic D; Srdic T; Veljkovic V; Colombatti A; R&D Division, Diapharm, Belgrade, Yugoslavia, and Diapharm Ltd.,; St. Peterport, Guernsey, Channel Islands, UK. os2@ets.it; It was recently shown that antibodies reactive with a peptide from the tip of the HIV-1NY5 gp120 V3 loop (V3 peptide) are present not only in sera of HIV-positive patients but also in sera of healthy HIV-negative individuals. In the present study, we show that V3 peptide reactive antibodies are predominantly IgM in se
Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-1 infection.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):271-6. Unique Identifier : AIDSLINE MED/99355058; Gisslen M; Fuchs D; Svennerholm B; Hagberg L; Department of Infectious Diseases, Goteborg University, Sweden.; To assess the association between cerebrospinal fluid (CSF) viral load, intrathecal immunoactivation, and immunosuppression in HIV-1-infected individuals with no antiretroviral treatment experience a cross-sectional study of stored frozen CSF and plasma samples were conducted. The study population included a total of
Presence of mutation conferring resistance to lamivudine in plasma and cerebrospinal fluid of HIV-1-infected patients.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):277-80. Unique Identifier : AIDSLINE MED/99355059; Chien JW; Valdez H; McComsey G; McClernon D; St. Clair M; Lederman MM; University Hospitals of Cleveland and Case Western Reserve; University Center for AIDS Research, Ohio 44106-5083, USA.; To explore the relation between levels of HIV-1 in the cerebrospinal fluid (CSF) and plasma, simultaneously obtained samples from twelve patients who were receiving or had received lamivudine were examined. HIV-1 RNA levels were measured by nucleic acid sequence-based amplification procedure (NASBA). HIV-1 pol gene wa
Efficacy and safety of delavirdine mesylate with zidovudine and didanosine compared with two-drug combinations of these agents in persons with HIV disease with CD4 counts of 100 to 500 cells/mm3 (ACTG 261). ACTG 261 Team.: Unique Identifier : AIDSLINE MED/99355060; Friedland GH; Pollard R; Griffith B; Hughes M; Morse G; Bassett R; Freimuth W; Demeter L; Connick E; Nevin T; Hirsch M; Fischl M; AIDS Program-Yale School of Medicine, Yale University, New Haven,; Connecticut 06510-2483, USA.; To evaluate the antiretroviral activity of delavirdine mesylate, a non-nucleoside reverse transcriptase inhibitor of HIV-1, we performed a phase II, randomized, double-blind, multicenter trial comparing the three-drug combination of delavirdine with z
Access to and utilization of primary care services among HIV-infected women.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):293-300. Unique Identifier : AIDSLINE MED/99355061; Palacio H; Shiboski CH; Yelin EH; Hessol NA; Greenblatt RM; AIDS Program at San Francisco General Hospital, Department of; Medicine, University of California, San Francisco, School of; Medicine, USA. herminia_palacio@dph.sf.ca.us; OBJECTIVES: To identify factors associated with the use of medical services, and to test a model of access to care, among HIV-infected women. METHODS: A cross-sectional telephone survey was administered to 213 HIV-infected women. Outcomes were having a primary care provider, and use of primary care and emergency healt
Treatment of mucocutaneous herpes simplex virus infections unresponsive to acyclovir with topical foscarnet cream in AIDS patients: a phase I/II study.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):301-6. Unique Identifier : AIDSLINE MED/99355062; Javaly K; Wohlfeiler M; Kalayjian R; Klein T; Bryson Y; Grafford K; Martin-Munley S; Hardy WD; New York University School of Medicine, New York, USA.; The efficacy and toxicity of foscarnet cream for the treatment of mucocutaneous herpes simplex virus lesions or lesions that were clinically unresponsive to systemic acyclovir treatment (median, 30.5 days) in AIDS patients were studied in a phase I/II, open-label, nonrandomized
Ritonavir combination therapy restores intestinal function in children with advanced HIV disease.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):307-12. Unique Identifier : AIDSLINE MED/99355063; Canani RB; Spagnuolo MI; Cirillo P; Guarino A; Department of Pediatrics, University Federico II, Naples, Italy.; OBJECTIVES: To investigate the intestinal absorptive processes in children with HIV infection before and after treatment with combination therapy that includes ritonavir. To test the hypothesis that combination therapy improves intestinal function. DESIGN: Intestinal f
Seroprevalence of HIV among female sex workers in Bangkok: evidence of ongoing infection risk after the "100% condom program" was implemented.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):313-6. Unique Identifier : AIDSLINE MED/99355064; Kilmarx PH; Palanuvej T; Limpakarnjanarat K; Chitvarakorn A; St. Louis ME; Mastro TD; The HIV/AIDS Collaboration, Nonthaburi, Thailand, Ministry of; Public Health, Nonthaburi, Thailand. pbk4@cdc.gov; BACKGROUND: After implementation in 1991 of a nationwide campaign to promote condom use during commercial sex, HIV-1 seroprevalence among young men began to decrease in 1994. However, it is unknown to what degree female sex workers (FSWs) have been protected from infection. METHODS: FSWs attending a government clinic
Effects of plasma HIV RNA, CD4+ T lymphocytes, and the chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs. Hemophilia Growth and Development Study.: Unique Identifier : AIDSLINE MED/99355065; Daar ES; Lynn H; Donfield S; Gomperts E; Hilgartner MW; Hoots K; Chernoff D; Winkler C; O'Brien SJ; We have investigated the effects of plasma HIV RNA, CD4+ T lymphocytes and chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs. We prospectively observed during follow-up 207 HIV-infected hemophiliacs in the Hemophilia Growth and Development Study. Plasma HIV RNA was measured on cryopreserved
Clinical presentation of hospitalized adult patients with HIV infection and AIDS in Bangkok, Thailand.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):326-32. Unique Identifier : AIDSLINE MED/99355066; Tansuphasawadikul S; Amornkul PN; Tanchanpong C; Limpakarnjanarat K; Kaewkungwal J; Likanonsakul S; Eampokalap B; Naiwatanakul T; Kitayaporn D; Young NL; Hu DJ; Mastro TD; Bamrasnaradura Infectious Disease Hospital, Department of; Communicable Disease Control, Ministry of Public Health,; Nonthaburi, Thailand.; OBJECTIVE: To characterize the clinical spectrum of disease and immune status of adult HIV-1-infected patients in Bangkok. DESIGN: Cross-sectional survey of hospital admissions. METHODS: From November 1993 through June 1996, demographic, clinical, and laboratory data were collected from HIV-infected inpatients (> or =
HIV-associated immune dysfunction and delayed pubertal development in a cohort of young hemophiliacs. Hemophilia Growth and Development Study.: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):333-7. Unique Identifier : AIDSLINE MED/99355067; Mahoney EM; Donfield SM; Howard C; Kaufman F; Gertner JM; Department of Medicine, Emory University School of Medicine,; Atlanta, Georgia 30322, USA. eliz@hp3.eushc.org; As part of the Hemophilia Growth and Development Study (HGDS), we investigated the relationship between HIV-associated immune dysfunction and delayed pubertal development in a cohort of 333 boys and adolescents with moderate or severe hemophilia who were between the ages of 6 and 19 years at study entry in 1989. Sixty
HIV monitoring in Vietnam: system, methodology, and results of sentinel surveillance.: Unique Identifier : AIDSLINE MED/99355068; Nguyen TH; Hoang TL; Pham KC; van Ameijden EJ; Deville W; Wolffers I; Department of Hygiene--Environment and Epidemiology, Hanoi; Medical College, Dong da, Hanoi, Vietnam. vnholand@netnam.org.vn; OBJECTIVE: To measure the prevalence of and trends in HIV infections in populations defined by sentinel surveillance in Vietnam . METHODS: Surveillance was conducted in eight provinces in 1994, expanded to 12 in 1995 and to 20 in 1996. Sentinel populations were sexually transmitted
Antiviral effect of AZT versus stavudine in combination with lamivudine and indinavir in the context of a populational study [letter]: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):347-8. Unique Identifier : AIDSLINE MED/99355069; Jahnke N; Yip B; Hogg RS; O'Shaughnessy M; Montaner JS
Variations in inpatient care for HIV-related tuberculosis patients during a recent nosocomial outbreak of multidrug-resistant tuberculosis [letter]: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):348-9. Unique Identifier : AIDSLINE MED/99355070; Bennett CL; Schwartz D; Lane DR; Sipler AM; Bhattacharya M; Kozloff M; Berland D; Pitrak D; Moswin A; Luskin-Hawk R; Weinstein RA
Reduced infections with HIV and hepatitis A during a Swiss intravenous opiate maintenance program [letter]: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):349-51. Unique Identifier : AIDSLINE MED/99355071; Naef MR; Bucher HC; Erb P; Gyr N; Bassetti S; Battegay M
Chronic diarrhea and weight loss in HIV-infected patients [letter]: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):351-3. Unique Identifier : AIDSLINE MED/99355072; Ehrenpreis E
Is there a focus of HTLV-II infections in the Horn of Africa? [letter]: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):353-4. Unique Identifier : AIDSLINE MED/99355073; Andersson S; Tessema HG; Wahren B
Low prevalence of HTLV-I/II infection among HIV-1-infected injecting drug users in Russia [letter]: J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):354. Unique Identifier : AIDSLINE MED/99355074; Bobkova MR; Detkova NV; Buravtsova EV; Bondarenko VO; Bobkov AF; Pokrovsky VV; Taylor GP
Pharmacokinetics of zidovudine in infants: a population analysis across studies.: Clin Pharmacol Ther. 1999 Jul;66(1):16-24. Unique Identifier : AIDSLINE MED/99357174; Mirochnick M; Capparelli E; Connor J; Department of Pediatrics, Boston Medical Center and Boston; University School of Medicine, Mass 02118, USA.; BACKGROUND: Although the use of zidovudine in newborns and infants has become standard therapy for prophylaxis and therapy of human immunodeficiency virus infection, the developmental pharmacology of zidovudine in the first months of life has not been fully described. METHODS: We used population analysis to estimate z
Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam.: Clin Pharmacol Ther. 1999 Jul;66(1):33-9. Unique Identifier : AIDSLINE MED/99357176; Palkama VJ; Ahonen J; Neuvonen PJ; Olkkola KT; Department of Anesthesia, University of Helsinki, Finland.; OBJECTIVE: To assess the effect of human immunodeficiency virus protease inhibitor saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam. METHODS: In a double-blind, randomized, two-phase crossover study, 12 healthy volunteers (six men and six women; age range, 21 to 32 years) recei
Understanding the intention of dentists to provide dental care to HIV+ and AIDS patients.: Community Dent Oral Epidemiol. 1999 Jun;27(3):221-7. Unique Identifier : AIDSLINE MED/99312087; Godin G; Naccache H; Brodeur JM; Alary M; Research Group on Psychosocial Aspects of Health Related; Behaviors, Laval University, St-Foy, Quebec, Canada.; gaston.godin@fsi.ulaval.ca; OBJECTIVE: The aim of this study was to understand the intention of dentists to provide dental care to HIV+/AIDS patients. METHODS: A representative sample of 791 dentists from the province of Quebec completed a questionnaire assessing their intention to provide dental care to individuals with HIV+/AIDS as well as the
[AIDS counseling]: Sogo Kango. 1997 Nov;32(4):13-8. Unique Identifier : AIDSLINE MED/99356321; Kosugi S
[AIDS counseling]: Sogo Kango. 1998 Feb;33(1):57-64. Unique Identifier : AIDSLINE MED/99356333; Kosugi S
Optical testing of condoms.: Contraception. 1999 Jan;59(1):47-57. Unique Identifier : AIDSLINE MED/99273631; Smith SR; Lowrance JL; Tessarotto LA; Princeton Scientific Instruments, Inc., Monmouth Junction, New; Jersey 08852, USA. ssmith@prinsci.com; Condoms provide one of the most important means of preventing pregnancy and the spread of human immunodeficiency virus (HIV) and other sexually transmitted diseases. Pinhole defects may lead to the passage of sperm or viruses through the condom wall. Embedded particles, which may become dislodged in handling or use, m
Measuring interstate variations in drug problems.: Drug Alcohol Depend. 1999 Jan 7;53(2):125-45. Unique Identifier : AIDSLINE MED/99179775; McAuliffe WE; LaBrie R; Lomuto N; Betjemann R; Fournier E; Department of Psychiatry, Harvard Medical School, National; Technical Center for Substance Abuse Needs Assessment, North; Charles Research and Planning Group, Cambridge, MA 02139, USA.; This article describes the Drug Problem Index (DPI), a composite index measuring the interstate severity of drug abuse problems. The DPI s components (drug-coded mortality, drug-defined arrest, and drug-treatment client rates) were selected because they were linked closely with drug abuse, data were available for all
Cytomegalovirus reactivation in patients infected with HIV: the use of polymerase chain reaction in prediction and management.: Drugs. 1999 May;57(5):735-41. Unique Identifier : AIDSLINE MED/99279738; Bowen EF; Department of Virology, Royal Free Hospital and School of; Medicine, London, England. efrances.bowen@btinternet.com; Patients with HIV are living longer now than in the past, and with a better quality of life. During the advanced stages of HIV infection patients are at risk of cytomegalovirus ( CMV ) reactivation and subsequently CMV disease.
The interactions of the N-terminal fusogenic peptide of HIV-1 gp41 with neutral phospholipids.: Eur Biophys J. 1999;28(5):427-36. Unique Identifier : AIDSLINE MED/99342269; Curtain C; Separovic F; Nielsen K; Craik D; Zhong Y; Kirkpatrick A; Department of Physics, Monash University, Clayton, Victoria,; Australia. ccurtain@vaxc.cc.monash.edu.au; We have studied the interactions with neutral phospholipid bilayers of FPI, the 23-residue fusogenic N-terminal peptide of the HIV-1LAI transmembrane glycoprotein gp41, by CD, EPR, NMR, and solid state NMR (SSNMR) with the objective of understanding how it lyses and fuses cells. Using small unilamellar vesicles made f
CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth.: Eur J Immunol. 1999 Jul;29(7):2148-55. Unique Identifier : AIDSLINE MED/99354931; Esche C; Gambotto A; Satoh Y; Gerein V; Robbins PD; Watkins SC; Lotze MT; Shurin MR; Biologic Therapeutics Program, University of Pittsburgh Cancer; Institute, PA 15213, USA.; We have recently demonstrated that murine and human tumors induce apoptosis of dendritic cells (DC). Here, we evaluated the effect of CD40 ligation on the survival of tumor-associated DC and tumor growth. Retroviral transduction of MC38 colon carcinoma cells with the CD154 gene resulted in inhibition of tumor growth.
Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo.: Eur J Immunol. 1999 Jul;29(7):2156-66. Unique Identifier : AIDSLINE MED/99354932; Bachmann MF; Speiser DE; Mak TW; Ohashi PS; Basel Institute for Immunology, Switzerland. bachmann@bii.ch; Understanding the mechanisms of T cell activation versus induction of unresponsiveness is of critical importance for the rational modulation of immune responses. Efficient T cell activation is critical for vaccination purposes, while the inhibition of T cell responses is potentially important for the ablation of autoi
T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens.: Eur J Immunol. 1999 Jul;29(7):2197-204. Unique Identifier : AIDSLINE MED/99354936; Grufman P; Wolpert EZ; Sandberg JK; Karre K; Microbiology and Tumor Biology Center, Karolinska Institutet,; Stockholm, Sweden. Per.Grufman@mtc.ki.se; We recently demonstrated that spleen cells primed against dominant BALB.B antigens can inhibit the cytotoxic T lymphocyte (CTL) response against subdominant antigens in vitro. In this study, we show that this interference is dependent on CD8+, but not CD4+, T cells directed against dominant antigens. Similar to immuno
Relaxin favors the development of activated human T cells into Th1-like effectors.: Eur J Immunol. 1999 Jul;29(7):2241-7. Unique Identifier : AIDSLINE MED/99354941; Piccinni MP; Bani D; Beloni L; Manuelli C; Mavilia C; Vocioni F; Bigazzi M; Sacchi TB; Romagnani S; Maggi E; Department of Internal Medicine, University of Florence, Italy.; Differentiation of naive CD4+ helper T (Th) cells into Th1 or Th2 effectors, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. In this study, we demonstrate that porcine relaxin, at concentrations ranging from 10(-10) to 10(-6) M, favors the in
Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3.: Eur J Immunol. 1999 Jul;29(7):2248-58. Unique Identifier : AIDSLINE MED/99354942; Bleijs DA; de Waal-Malefyt R; Figdor CG; van Kooyk Y; Department of Tumor Immunology, University Hospital Nijmegen, The; Netherlands.; The LFA-1 adhesion molecule is involved in cell adhesion events of leukocytes through binding to ICAM-1, ICAM-2 and ICAM-3. Whether binding to either of these ligands similarly affects co-stimulation of T cells and cytokine secretion is unknown. We demonstrated that LFA-1 co-stimulation under suboptimal concentrations
Retrovirally induced switch from production of IL-12 to IL-4 in dendritic cells.: Eur J Immunol. 1999 Jul;29(7):2309-18. Unique Identifier : AIDSLINE MED/99354948; Kelleher P; Maroof A; Knight SC; Antigen Presentation Research Group, Imperial College School of; Medicine, Northwick Park Institute for Medical Research, Harrow,; Middlesex, GB.; Dendritic cells (DC) in HIV-1 infection show a reduced capacity to stimulate primary T cell proliferation. Exposure of bone marrow-derived DC to Rauscher leukemia virus (RLV) provides a mouse model for studying retrovirally induced reduction in stimulatory capacity for T cells. Treatment with IL-12, a cytokine that pr
The N-linked glycan of the V3 region of HIV-1 gp120 and CXCR4-dependent multiplication of a human immunodeficiency virus type 1 lymphocyte-tropic variant.: FEBS Lett. 1999 Jul 2;454(1-2):47-52. Unique Identifier : AIDSLINE MED/99339438; Losman B; Biller M; Olofsson S; Schonning K; Lund OS; Svennerholm B; Hansen JE; Bolmstedt A; Department of Clinical Virology, University of Goteborg, Sweden.; We have previously shown that an N-glycosylation site of N306 of HIV-1 gp120 is not necessary for the HIV-1 infectivity but protects HIV-1 from neutralising antibodies. In contrast Nakayama et al. [FEBS Lett. (1998) 426, 367-372], using a virus with an identical V3 region, suggested that elimination of this particular
HIV-HCV RNA loads and liver failure in coinfected patients with coagulopathy.: Haematologica. 1999 Jun;84(6):525-9. Unique Identifier : AIDSLINE MED/99299325; Dragoni F; Cafolla A; Gentile G; Mazzucconi MG; Vella S; Di Corpo U; Tosti ME; Pisani G; Donato V; Martino P; Dipartimento di Biotecnologie Cellulari ed Ematologia, Univ. "La; Sapienza", Rome, Italy.; BACKGROUND AND OBJECTIVE: The aim of this study was to measure contemporaneously HCV-RNA load, HIV-RNA load and CD4+ lymphocyte count in HCV/HIV coinfected patients with coagulopathy and to examine the relationship between these parameters and the liver failure. DESIGN AND METHODS: A cross-sectional study was performe
Empowerment evaluation as a social work strategy.: Health Soc Work. 1999 May;24(2):120-7. Unique Identifier : AIDSLINE MED/99271521; Secret M; Jordan A; Ford J; College of Social Work, University of Kentucky, Lexington; 40506-0027, USA. mcsecr@pop.uky.edu; This article explores the application of empowerment strategies to program evaluation within a community health setting and presents a case study to examine the policy, direct practice, and research issues associated with the plan to evaluate a community-based HIV-prevention program. Empowerment evaluation strategies
Risky sex behavior and substance use among young adults.: Health Soc Work. 1999 May;24(2):147-54. Unique Identifier : AIDSLINE MED/99271524; Staton M; Leukefeld C; Logan TK; Zimmerman R; Lynam D; Milich R; Martin C; McClanahan K; Clayton R; Center on Drug and Alcohol Research, University of Kentucky,; Lexington 40506, USA. cmstat00@pop.uky.edu; Many young adults, despite widespread prevention and education efforts that target this age group, engage in behaviors that place them at risk of HIV infection. These behaviors include frequent experimentation with alcohol and other drugs before sex, sexual activity with different partners, and inconsistent safe-sex p
B7-1 (CD80)-gene transfer combined with interleukin-12 administration elicits protective and therapeutic immunity against mouse hepatocellular carcinoma.: Hepatology. 1999 Aug;30(2):422-9. Unique Identifier : AIDSLINE MED/99350379; Tatsumi T; Takehara T; Kanto T; Kuzushita N; Ito A; Kasahara A; Sasaki Y; Hori M; Hayashi N; Department of Internal Medicine and Therapeutics, Osaka; University School of Medicine, Osaka, Japan.; Human hepatocellular carcinoma (HCC) frequently recurs after primary therapy, resulting in poor prognosis. To try to find a way to prevent this, we examined the combined effectiveness of B7-1 (CD80)-gene transfer and interleukin-12 (IL-12) on the induction of protective antitumor immunity against poorly immunogenic BN
Lamivudine for chronic delta hepatitis [see comments]: Hepatology. 1999 Aug;30(2):546-9. Unique Identifier : AIDSLINE MED/99350395; Lau DT; Doo E; Park Y; Kleiner DE; Schmid P; Kuhns MC; Hoofnagle JH; Liver Diseases Section, Digestive Diseases Branch, National; Institute of Diabetes and Digestive and Kidney Diseases, National; Institutes of Health, Bethesda, MD, USA.; Chronic delta hepatitis is a severe form of chronic liver disease caused by hepatitis delta virus (HDV) infection superimposed on chronic hepatitis B or the hepatitis B surface antigen (HBsAg) carrier state. Therapy of delta hepatitis is currently unsatisfactory. We have evaluated lamivudine (3-thiacytidine), an oral
Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy [see comments]: Hepatology. 1999 Aug;30(2):567-72. Unique Identifier : AIDSLINE MED/99350399; Liaw YF; Chien RN; Yeh CT; Tsai SL; Chu CM; Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung; University, Taipei, Taiwan.; Lamivudine is a potent inhibitor of hepatitis B virus (HBV) replication, but its long-term use may be associated with HBV tyrosine-methionine-aspartate-aspartate (YMDD) motif mutation. To examine the clinical features and course after emergence of YMD
Hepatitis B therapy: the plot thickens [comment]: Hepatology. 1999 Aug;30(2):579-81. Unique Identifier : AIDSLINE MED/99350402; Malik AH; Lee WM; Division of Digestive Diseases and Hepatology Department of; Internal Medicine University of Texas Southwestern Medical School; Dallas, TX, USA.
Immune activation in non-treated suicidal major depression.: Immunol Lett. 1999 Apr 1;67(2):105-8. Unique Identifier : AIDSLINE MED/99247350; Mendlovic S; Mozes E; Eilat E; Doron A; Lereya J; Zakuth V; Spirer Z; Shalvata Mental Health Center, Hod-Hasharon, Israel.; mendlov@netvision.net.il; In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is as
Transforming growth factor-beta1, a strong costimulator of rat T-cell activation promoting a shift towards a Th2-like cytokine profile.: Immunol Lett. 1999 Apr 1;67(2):131-9. Unique Identifier : AIDSLINE MED/99247355; Schiott A; Widegren B; Sjogren HO; Lindvall M; The Wallenberg Laboratory, Department of Tumor Immunology,; University of Lund, Sweden. asa.schiott@wblab.lu.se; TGF-beta is a known regulator of hematopoietic cells. In this study we suggest a major role of adherent spleen cells (adh-splc), to convert an inhibitory effect of TGF-beta1 on T-cell activation into a stimulatory effect. We show that interaction of TGF-beta1 with adh-splc induces a costimulatory effect on T-cell prol
Soluble tumor necrosis factor receptor type II (sTNFRII) in HIV-infected patients: relationship with the plasma level of HIV-1 RNA.: Immunol Lett. 1999 Apr 1;67(2):91-4. Unique Identifier : AIDSLINE MED/99247348; Hober D; Benyoucef S; Bocket L; Chieux V; Lion G; Mouton Y; De Groote D; Wattre P; Laboratoire de Virologie, Institut Gernez-Rieux, Centre; Hospitalier et Universitaire, Lille, France. dhober@chru-lille.fr; The value of soluble receptor for tumor necrosis factor type II (sTNFRII) as a strong and early predictor of HIV disease progression was suggested. Recently it has been reported that sTNFRII may provide an indication of the HIV load. In this work we focused on the relationship between sTNFRII and HIV burden in 95 HIV-
Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene.: Infect Immun. 1999 Aug;67(8):3855-63. Unique Identifier : AIDSLINE MED/99346171; Rodrigues MM; Ribeirao M; Pereira-Chioccola V; Renia L; Costa F; Departmento de Microbiologia, Imunologia e Parasitologia,; Universidade Federal de Sao Paulo-Escola Paulista de Medicina,; Sao Paulo, Brazil. Rodriguesm.dmip@epm.br; Immunization with a plasmid DNA containing the gene encoding the catalytic domain of trans-sialidase (TS) elicits protective immune responses against experimental Trypanosoma cruzi infection. As several studies provided strong evidence that during infection CD4 Th1 and CD8 T cytotoxic type 1 (Tc1) cells are important
Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice.: Infect Immun. 1999 Aug;67(8):3980-8. Unique Identifier : AIDSLINE MED/99346186; Serbina NV; Flynn JL; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Several lines of evidence suggest that CD8 T cells are important in protection against tuberculosis. To understand the function of this cell population in the immune response against Mycobacterium tuberculosis, T cells from lungs of M. tuberculosis-infected mice were examined by flow cytometry. The kinetics of the app
Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan.: Infect Immun. 1999 Aug;67(8):4295-7. Unique Identifier : AIDSLINE MED/99346231; Juffermans NP; Verbon A; van Deventer SJ; van Deutekom H; Belisle JT; Ellis ME; Speelman P; van der Poll T; Laboratory of Experimental Internal Medicine, Academic Medical; Center, University of Amsterdam, Amsterdam, The Netherlands.; N.Juffermans@amc.uva.nl; Levels of interleukin 8 (IL-8), gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1beta (MIP-1beta) were elevated in patients with tuberculosis. IP-10 and MCP-1 levels were higher in human immunodeficiency virus (HIV)-seropositive patients th
Genetic and phenotypic intraspecific variation in the microsporidian Encephalitozoon hellem.: Int J Parasitol. 1999 May;29(5):767-70. Unique Identifier : AIDSLINE GENBANK/AF110328; Mathis A; Tanner I; Weber R; Deplazes P; Institute of Parasitology, University of Zurich, Switzerland.; maal@vetparas.unizh.ch; Encephalitozoon hellem is a microsporidian species that causes disseminated infections in HIV-positive patients. Identical genotypes of E. hellem, as assessed by the sequence of the rDNA internal transcribed spacer, have been identified in isolates from humans and from a psittacine bird. However, by analysing the rDNA
[The users of centers for AIDS information and prevention in the Comunidad Valenciana, Spain: a study based on cluster analysis]: Gac Sanit. 1999 Mar-Apr;13(2):102-8. Unique Identifier : AIDSLINE MED/99284649; Gonzalez Aracil J; Ruiz Perez I; Avino Rico MJ; Hernandez Aguado I; Area de Epidemiologia y Estadistica, Institut Valencia; d'Estudis en Salut Publica (IVESP), Valencia, 46017, Espana.; OBJECTIVE: To measure the usefulness of multiple correspondence analysis (MCA) and cluster analysis applied to the epidemiological research of HIV infection. The specific are to explore the relationships between the different variables that characterize the users of the AIDS Information and Prevention Center (CIPS) an
[The persistence of risky conduct for HIV transmission among intravenous drug users in Madrid, Seville, and Valencia. The Working Group of the Medicos del Mundo for the Monitoring of HIV Infection and the Risk Practices of Intravenous Drug Users (see comments)]: Gac Sanit. 1999 Mar-Apr;13(2):109-18. Unique Identifier : AIDSLINE MED/99284650; Bravo MJ; Barrio G; de la Fuente L; Colomo C; Royuela L; Medicos del Mundo, Madrid, Espana.; OBJECTIVE: To determine the prevalence of HIV infection and risk-taking behavior for infection among intravenous drug users in Madrid, Seville, and Valencia ( Spain ). To study the main factors associated with such behavior. MATERIAL AND METHODS: Personal interviews were carried out w
[AIDS patients with an unclassified risk factor for HIV]: Gac Sanit. 1999 Mar-Apr;13(2):119-25. Unique Identifier : AIDSLINE MED/99284651; Martinez Alonso JL; Maguire A; Domuczicz K; Vall Mayans M; Miret Mases M; Casabona Barbara J; Departament de Sanitat i Seguretat Social, Generalitat de; Catalunya, Barcelona, 08028, Espana.; OBJECTIVES: In the surveillance of the AIDS epidemic via registries there is a small proportion of cases whose route of HIV transmission is unknown (5% for Catalonia, Spain ). For reclassification purposes, the aim of this study is to detect similarities between these cases with not
[AIDS prevention among adolescents in school: a systematic review of the efficacy of interventions]: Gac Sanit. 1999 Mar-Apr;13(2):150-62. Unique Identifier : AIDSLINE MED/99284655; Juarez O; Diez E; Centre d'Estudis per a la Prevencio de la SIDA, Institut; Municipal de Salut Publica, Barcelona, 08023, Espana.; BACKGROUND AND AIMS: Preventive interventions are considered useful although poorly evaluated. Since 1990 there are growing evidences of effective school aids prevention interventions. This paper aims to identify school aids prevention programs among youngsters aged 13 to 19, published between 1990 and 1995, to analyz
Indinavir crystallization and urolithiasis.: Int Urol Nephrol. 1999;31(1):23-9. Unique Identifier : AIDSLINE MED/99334783; Grases F; Costa-Bauza A; Garcia-Gonzalez R; Payeras A; Bassa A; Torres JJ; Conte A; Laboratory of Urolithiasis Research, University of Illes Balears,; Spain.; The crystallization of indinavir in synthetic urine at different pH values and indinavir concentrations was kinetically studied. It was found that precipitation time notably decreases at urinary pH values above 6.0. The effects of some products as pot
Human immunodeficiency virus type 2 infection in Spain. The HIV-2 Spanish Study Group.: Intervirology. 1999;42(1):37-42. Unique Identifier : AIDSLINE MED/99321830; Machuca A; Soriano V; Guti rrez M; Holguin A; Aguilera A; Caballero E; Cilla G; Service of Infectious Diseases and Microbiology, Hospital Carlos; III, Instituto de Salud Carlos III, Madrid, Spain.; The first cases of human immunodeficiency virus type 2 (HIV-2) infection in Spain were identified in 1988, in 3 African immigrants living in Barcelona. Since then, up to December 1998, 92 individuals with HIV-2 infection have been reported in Spain. Most are adult men, infected thro
[Kaposiform HHV-8 negative acroangiodermatitis in chronic venous insufficiency]: Hautarzt. 1999 Mar;50(3):208-13. Unique Identifier : AIDSLINE MED/99248474; Krengel S; Goerdt S; Kruger K; Schnitzler P; Geiss M; Tebbe B; Blume-Peytavi U; Orfanos CE; Hautklinik und Poliklinik, Universitatsklinikum Benjamin; Franklin, Freie Universitat Berlin.; A 76-year-old female patient developed severe manifestations of a kaposi-like acroangiodermatitis (so-called Mali s disease) due to chronic venous insufficiency of the lower extremities. The patient presented with large areas of confluent, violaceous or brown-black papules on both lower legs. Histologically, prolifera
Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains.: J Antimicrob Chemother. 1998 Dec;42(6):747-53. Unique Identifier : AIDSLINE MED/99160263; Maesaki S; Marichal P; Hossain MA; Sanglard D; Vanden Bossche H; Kohno S; The Second Department of Internal Medicine, Nagasaki University; School of Medicine, Japan.; We investigated the effects of combining tacrolimus and azole antifungal agents in azole-resistant strains of Candida albicans by comparing the accumulation of [3H]itraconazole. The CDR1-expressing resistant strain C26 accumulated less itraconazole than the CaMDR-expressing resistant strain C40 or the azole-sensitive
Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.: J Antimicrob Chemother. 1998 Dec;42(6):761-7. Unique Identifier : AIDSLINE MED/99160265; Van Bambeke F; Gerbaux C; Michot JM; d'Yvoire MB; Montenez JP; Tulkens PM; Unite de Pharmacologie Cellulaire et Moleculaire, Uinversite; Catholique de Louvain, Brussels, Belgium.; vanbambeke@facm.ucl.ac.be; Computer-aided simulations suggest that the doses and schedules of administration of azithromycin proposed in treatment and prophylaxis of Mycobacterium avium complex (MAC) in AIDS patients will result in drug concentrations in serum and extracellular fluids remaining for sustained periods of time in the 0.03-0.1 mg/L
Minimizing DNA recombination during long RT-PCR.: J Virol Methods. 1998 Dec;76(1-2):139-48. Unique Identifier : AIDSLINE MED/99120623; Fang G; Zhu G; Burger H; Keithly JS; Weiser B; Wadsworth Center, New York State Department of Health, Albany; 12201, USA.; Recent developments have made it possible to reverse transcribe RNA and amplify cDNA molecules of > 10 kb in length, including the HIV-1 genome. To use long reverse transcription combined with polymerase chain reaction (RT-PCR) to best advantage, it is necessary to determine the frequency of recombination during the c
Isolation of HIV-1 RNA from plasma: evaluation of seven different methods for extraction (part two).: J Virol Methods. 1998 Dec;76(1-2):153-7. Unique Identifier : AIDSLINE MED/99120625; Fransen K; Mortier D; Heyndrickx L; Verhofstede C; Janssens W; van der Groen G; Instituut voor Tropische Geneeskunde, Departement Microbiologie,; Antwerpen, Belgium.; Some new commercial methods for the extraction of viral RNA have been introduced recently. In addition to the study published previously (Verhofstede, C., Reniers, S., Van Wanzeele. F., Plum J., 1996. AIDS 8, 1421-1427), seven different methods (four newly developed and three reference methods) for extraction of HIV-1
Strongly enhanced sensitivity of a direct anti-HIV-1/-2 assay in seroconversion by incorporation of HIV p24 ag detection: a new generation vironostika HIV Uni-Form II.: J Virol Methods. 1998 Dec;76(1-2):59-71. Unique Identifier : AIDSLINE MED/99120615; van Binsbergen J; Keur W; Siebelink A; van de Graaf M; Jacobs A; de Rijk D; Nijholt L; Toonen J; Gurtler LG; Organon Teknika, Boxtel, The Netherlands.; The clinical sensitivity of the current anti-HIV assays is based for an important part on their reactivity with seroconversion panels. The most sensitive assay closes the seroconversion window as much as possible, thereby reducing the risk of transmitting false negative donations obtained from individuals infected rec
Simplified procedure for fractionation and structural characterisation of complex mixtures of N-linked glycans, released from HIV-1 gp120 and other highly glycosylated viral proteins.: J Virol Methods. 1998 Dec;76(1-2):87-100. Unique Identifier : AIDSLINE MED/99120618; Biller M; Bolmstedt A; Hemming A; Olofsson S; Department of Virology, University of Goteborg, Sweden.; HIV-1 gp120 is heavily glycosylated containing 24 N-glycosylation sites, and this makes elucidation of the significance of glycans at individual glycosylation sites a difficult task. A procedure is described where a complex mixture of biologically radiolabelled glycans of gp120, derived from a relatively small number
Effects of anticoagulant, processing delay, and assay method (branched DNA versus reverse transcriptase PCR) on measurement of human immunodeficiency virus type 1 RNA levels in plasma.: Unique Identifier : AIDSLINE MED/99335514; Kirstein LM; Mellors JW; Rinaldo CR Jr; Margolick JB; Giorgi JV; Phair JP; Dietz E; Gupta P; Sherlock CH; Hogg R; Montaner JS; Munoz A; We conducted two studies to determine the potential influence of delays in blood processing, type of anticoagulant, and assay method on human immunodeficiency virus type 1 (HIV-1) RNA levels
Genotype dependence of hepatitis C virus load measurement in commercially available quantitative assays.: J Clin Microbiol. 1999 Aug;37(8):2525-32. Unique Identifier : AIDSLINE MED/99335530; Mellor J; Hawkins A; Simmonds P; Department of Medical Microbiology, University of Edinburgh,; Edinburgh EH8 9AG, United Kingdom.; Standardization and genotype independence of methods used to quantify hepatitis C virus (HCV) RNA in clinical specimens are necessary for accurate assessment of the role of HCV quantitation as a prognostic marker for HCV infection and monitoring of the response to antiviral treatment. Commercially available methods us
Performance of the Affymetrix GeneChip HIV PRT 440 platform for antiretroviral drug resistance genotyping of human immunodeficiency virus type 1 clades and viral isolates with length polymorphisms.: J Clin Microbiol. 1999 Aug;37(8):2533-7. Unique Identifier : AIDSLINE MED/99335531; Vahey M; Nau ME; Barrick S; Cooley JD; Sawyer R; Sleeker AA; Vickerman P; Bloor S; Larder B; Michael NL; Wegner SA; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA. mvahey@pasteur.hjf.org; The performance of a silica chip-based resequencing method, the Affymetrix HIV PRT 440 assay (hereafter referred to as the Affymetrix assay), was evaluated on a panel of well-characterized nonclade B viral isolates and on isolates exhibiting length polymorphisms. Sequencing of human immunodeficiency virus type 1 (HIV-
Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes.: J Clin Microbiol. 1999 Aug;37(8):2557-63. Unique Identifier : AIDSLINE MED/99335536; Michael NL; Herman SA; Kwok S; Dreyer K; Wang J; Christopherson C; Spadoro JP; Young KK; Polonis V; McCutchan FE; Carr J; Mascola JR; Jagodzinski LL; Robb ML; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.; nmaichael@pasteur.hjf.org; Accurate determination of plasma human immunodeficiency virus type 1 (HIV-1) RNA levels is critical for the effective management of HIV-1 disease. The AMPLICOR HIV-1 MONITOR Test, a reverse transcription-PCR-based test for quantification of HIV-1 RNA in plasma, was developed when little sequence information on HIV-1 i
Detection of phylogenetically diverse human immunodeficiency virus type 1 groups M and O from plasma by using highly sensitive and specific generic primers.: J Clin Microbiol. 1999 Aug;37(8):2581-6. Unique Identifier : AIDSLINE MED/99335540; Yang C; Pieniazek D; Owen SM; Fridlund C; Nkengasong J; Mastro TD; Rayfield MA; Downing R; Biryawaho B; Tanuri A; Zekeng L; van der Groen G; Gao F; Lal RB; HIV and Retrovirology Branch, Division of AIDS, STD, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; The high degree of genetic diversity within human immunodeficiency virus type 1 (HIV-1), which includes two major groups, M (major) and O (outlier), and various env subtypes within group M (subtypes A to J), has made designing assays that will detect all known HIV-1 strains difficult. We have developed a generic prime
Identification of two novel Mycobacterium avium allelic variants in pig and human isolates from Brazil by PCR-restriction enzyme analysis.: J Clin Microbiol. 1999 Aug;37(8):2592-7. Unique Identifier : AIDSLINE GENBANK/AF126035; Leao SC; Briones MR; Sircili MP; Balian SC; Mores N; Ferreira-Neto JS; Departamento de Microbiologia, Imunologia e Parasitologia,; Universidade Federal de Sao Paulo-Escola Paulista de Medicina,; Sao Paulo, Brazil. scleao.dmip@epm.br; Mycobacterium avium complex (MAC) is composed of environmental mycobacteria found widely in soil, water, and aerosols that can cause disease in animals and humans, especially disseminated infections in AIDS patients. MAC consists of two closely related species, M. avium and M. intracellulare, and may also include othe
Indigenous disseminated Penicillium marneffei infection in the state of Manipur, India: report of four autochthonous cases.: J Clin Microbiol. 1999 Aug;37(8):2699-702. Unique Identifier : AIDSLINE MED/99335560; Singh PN; Ranjana K; Singh YI; Singh KP; Sharma SS; Kulachandra M; Nabakumar Y; Chakrabarti A; Padhye AA; Kaufman L; Ajello L; Department of Medicine, J. N. Medical Hospital, Imphal, Manipur,; India.; We describe four cases of disseminated infection caused by endemic Penicillium marneffei in human immunodeficiency virus (HIV)-infected patients from the Manipur state of India . The most common clinical features observed were fever, anorexia, weight loss, hepatosplenomegaly, and, mo
An uncommon Helicobacter isolate from blood: evidence of a group of Helicobacter spp. pathogenic in AIDS patients.: J Clin Microbiol. 1999 Aug;37(8):2729-33. Unique Identifier : AIDSLINE MED/99335569; Weir SC; Gibert CL; Gordin FM; Fischer SH; Gill VJ; Microbiology Service, Clinical Pathology Department, National; Institutes of Health, Bethesda, Maryland 20892, USA.; An unusual Helicobacter sp. was isolated from the blood of a human immunodeficiency virus (HIV)-infected patient. This organism had spiral morphology, with single amphitrichous flagella, and was negative for hippurate hydrolysis, production of urease, and reduction of nitrate. 16S rRNA gene sequence analysis verified
The role of protective CD8+ T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: regulatory vs. lytic.: J Neuroimmunol. 1999 Aug 3;98(2):136-46. Unique Identifier : AIDSLINE MED/99357116; Nicholson SM; Haynes LM; Vanderlugt CL; Miller SD; Melvold RW; Department of Microbiology-Immunology, Northwestern University; Medical School, Chicago, IL 60611, USA.; Theiler s murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8+ spleni
Partial blockade of T-cell differentiation during ontogeny and marked alterations of the thymic microenvironment in transgenic mice with impaired glucocorticoid receptor function.: J Neuroimmunol. 1999 Aug 3;98(2):157-67. Unique Identifier : AIDSLINE MED/99357118; Sacedon R; Vicente A; Varas A; Morale MC; Barden N; Marchetti B; Zapata AG; Department of Cell Biology, Faculty of Biology, Complutense; University, Madrid, Spain.; Glucocorticoids (GCs) are widely known to be potent modulators of the immune system. The role of GCs in thymopoiesis as well as the integration of the thymus with the neuroendocrine system is, however, poorly understood. In the present work, we have studied, in transgenic mice with an impaired GC function, the alterat
Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia.: J Neuroimmunol. 1999 Aug 3;98(2):185-200. Unique Identifier : AIDSLINE MED/99357121; Zheng J; Thylin MR; Ghorpade A; Xiong H; Persidsky Y; Cotter R; Niemann D; Che M; Zeng YC; Gelbard HA; Shepard RB; Swartz JM; Gendelman HE; Department of Pathology, University of Nebraska Medical Center,; Omaha 68198-5215, USA.; The mechanism(s) by which HIV-1 affects neural injury in HIV-1-associated dementia (HAD) remains unknown. To ascertain the role that cellular and viral macrophage products play in HAD neurotoxicity, we explored one potential route for neuronal demise, CXCR4. CXCR4, expressed on lym
Increased levels of soluble Fas ligand in CSF of rapidly progressive HTLV-1-associated myelopathy/tropical spastic paraparesis patients.: J Neuroimmunol. 1999 Aug 3;98(2):221-6. Unique Identifier : AIDSLINE MED/99357125; Saito M; Nakamura N; Nagai M; Shirakawa K; Sato H; Kawahigashi N; Furukawa Y; Usuku K; Nakagawa M; Izumo S; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan. m.saito@ic.ac.uk; The interaction of Fas ligand (FasL) with Fas-bearing cells induces apoptosis and contributes to the negative regulation of peripheral T-cell responses. Membrane-bound FasL is cleaved by a matrix metalloproteinase-like enzyme and converted to a soluble form (sFasL). Recent studies suggest that such sFasL can cause sys
B-cell responses to myelin basic protein and its epitopes in autoimmune encephalomyelitis induced by Semple rabies vaccine.: J Neuroimmunol. 1999 Aug 3;98(2):96-104. Unique Identifier : AIDSLINE MED/99357111; Piyasirisilp S; Hemachudha T; Griffin DE; Department of Molecular Microbiology and Immunology, The Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, MD 21205-2179, USA.; Semple rabies vaccine is composed of rabies virus-infected sheep or goat brain inactivated with phenol and is administered daily after exposure for 14-21 days. Semple rabies vaccine-induced autoimmune encephalomyelitis (SAE) has clinico-pathological findings of demyelination similar to experimental autoimmune encephal
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.: J Clin Invest. 1999 Jul;104(2):173-80. Unique Identifier : AIDSLINE MED/99340102; Dhodapkar MV; Steinman RM; Sapp M; Desai H; Fossella C; Krasovsky J; Donahoe SM; Dunbar PR; Cerundolo V; Nixon DF; Bhardwaj N; Laboratory of Immunology and Cellular Physiology, General; Clinical Research Center, and Aaron Diamond AIDS Research Center,; Rockefeller University, New York, New York 10021, USA.; dhodapm@rockvax.rockefeller.edu; Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously with a control injection of autologous monocyte-derived, mature DCs, followed 4-6 weeks later by DCs pulsed with keyhol
Comprehensive assessment of the components of energy expenditure in infants using a new infant respiratory chamber.: J Am Coll Nutr. 1999 Jun;18(3):233-41. Unique Identifier : AIDSLINE MED/99303272; Cole CR; Rising R; Hakim A; Danon M; Mehta R; Choudhury S; Sundaresh M; Lifshitz F; Maimonides Medical Center, Department of Pediatrics, Brooklyn,; New York, USA.; BACKGROUND: Current methods for energy expenditure (EE) measurements in term infants do not include simultaneous measurements of basal and sleeping metabolic rates (BMR and SMR) or a measure of physical activity (PA). Furthermore, prediction equations for calculating EE are not appropriate for use in infants with meta
Cutting edge: RANTES regulates Fas ligand expression and killing by HIV-specific CD8 cytotoxic T cells.: J Immunol. 1999 Aug 1;163(3):1105-9. Unique Identifier : AIDSLINE MED/99343711; Hadida F; Vieillard V; Mollet L; Clark-Lewis I; Baggiolini M; Debre P; Laboratoire d'Immunologie Cellulaire, Unite Mixte de Recherche; 7627, Centre National de la Recherche Scientifique Batiment; CERVI, Hopital Pitie-Salpetriere, Paris, France.; Based on the previous observation that RANTES mediates the cytotoxic activity of human HIV-specific CD8+ T cells via the chemokine receptor CCR3, we studied the effect of this chemokine on different effector CD8+ cytolytic cells requiring Fas/Fas ligand (FasL) or perforin-dependent pathway. In CTLs derived from PBMCs
Cutting edge: HIV-1 Tat protein differentially modulates the B cell response of naive, memory, and germinal center B cells.: J Immunol. 1999 Aug 1;163(3):1119-22. Unique Identifier : AIDSLINE MED/99343714; Lefevre EA; Krzysiek R; Loret EP; Galanaud P; Richard Y; Institut National de la Sante et de la Recherche Medicale Unit; 131, Institut Paris-sud sur les Cytokines, Clamart, France.; Critical steps of B cell differentiation occur within lymphoid organs that are also major sites of HIV-1 replication. Because Tat can be released by infected cells, we investigated whether extracellular HIV-1 Tat modulates cell proliferation of B cells at critical stages of their differentiation. Here we show that ext
CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation.: J Immunol. 1999 Aug 1;163(3):1133-42. Unique Identifier : AIDSLINE MED/99343717; Sepulveda H; Cerwenka A; Morgan T; Dutton RW; Molecular Pathology Program, University of California at San; Diego, La Jolla 92093.; We investigate, here, the mechanism of the costimulatory signals for CD8 T cell activation and confirm that costimulation signals via CD28 do not appear to be required to initiate proliferation, but provide survival signals for CD8 T cells activated by TCR ligation. We show also that IL-6 and TNF-alpha can provide alt
Th cells and Th2 responses can develop in the absence of MHC class II-CD4 interactions.: J Immunol. 1999 Aug 1;163(3):1162-9. Unique Identifier : AIDSLINE MED/99343720; Wack A; Corbella P; Harker N; Roderick K; Norton T; Williams K; Williams O; Kioussis D; Division of Molecular Immunology, National Institute for Medical; Research, London, United Kingdom.; In this paper, we address the question whether CD4 and MHC class II expression are necessary for the development of the T helper lineage during thymocyte maturation and for activation-induced Th2 responses. To bypass the CD4-MHC class II interaction requirements for positive selection and activation, we used mice that
Th1 cytokines and NK cells participate in the development of murine syngeneic graft-versus-host disease.: J Immunol. 1999 Aug 1;163(3):1170-7. Unique Identifier : AIDSLINE MED/99343721; Flanagan DL; Jennings CD; Bryson JS; Department of Microbiology, Department of Pathology, Division of; Hematology/Oncology, Markey Cancer Center, University of; Kentucky, Lexington 40536, USA.; Syngeneic graft-vs-host disease (SGVHD) is induced by reconstituting lethally irradiated mice with syngeneic bone marrow cells followed by a short course of therapy with the immunosuppressive agent cyclosporine A. Following cessation of cyclosporine A therapy, animals develop clinical symptoms of SGVHD: weight loss, r
Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent.: J Immunol. 1999 Aug 1;163(3):1178-87. Unique Identifier : AIDSLINE MED/99343722; Tisch R; Wang B; Serreze DV; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill 27599, USA. rmitsch@med.unc.edu; Peptide-based immunotherapy is one strategy by which to selectively suppress the T cell-mediated destruction of beta cells and treat insulin-dependent diabetes mellitus (IDDM). Here, we investigated whether a panel of T cell epitopes derived from the beta cell autoantigen glutamic acid decarboxylase 65 (GAD65) differ
Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance.: J Immunol. 1999 Aug 1;163(3):1205-13. Unique Identifier : AIDSLINE MED/99343725; Rogers PR; Croft M; Division of Immunochemistry, La Jolla Institute for Allergy and; Immunology, San Diego, CA 92121, USA.; Opposing viewpoints exist regarding how Ag dose and affinity modulate Th1/Th2 differentiation, with data suggesting that both high and low level stimulation favors Th2 responses. With transgenic T cells bearing a single TCR, we present novel data, using peptides differing in affinity for the TCR, that show that the ti
Expression of L-selectin on Th1 cells is regulated by IL-12.: J Immunol. 1999 Aug 1;163(3):1214-21. Unique Identifier : AIDSLINE MED/99343726; Wely CA; Beverley PC; Brett SJ; Britten CJ; Tite JP; Immunology Unit, Glaxo Wellcome Medicines Research Centre,; Stevenage, United Kingdom. cavw14089@glaxowellcome.co.uk; L-selectin has become established as a key molecule in the recirculation of naive T cells from the blood to peripheral lymph nodes, yet little is known about its role in the migration of effector or memory cells. While differentiating naive CD4+ T cells into Th1 and Th2 subsets in vitro, it was noted that L-selectin l
Functional similarity and differences between selection-independent CD4-CD8- alphabeta T cells and positively selected CD8 T cells expressing the same TCR and the induction of anergy in CD4-CD8- alphabeta T cells in antigen-expressing mice.: J Immunol. 1999 Aug 1;163(3):1222-9. Unique Identifier : AIDSLINE MED/99343727; Caveno J; Zhang Y; Motyka B; Teh SJ; Teh HS; Department of Microbiology and Immunology, University of British; Columbia, Vancouver, British Columbia, Canada.; In TCR-alphabeta transgenic mice, CD4-CD8- TCR-alphabeta+ (alphabeta DN) cells arise in the absence of positively selecting MHC molecules and are resistant to clonal deletion in Ag-expressing mice. In this study the activation requirements and functional properties of alphabeta double-negative (DN) cells were compared
IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis.: J Immunol. 1999 Aug 1;163(3):1230-6. Unique Identifier : AIDSLINE MED/99343728; Rothe H; Hausmann A; Casteels K; Okamura H; Kurimoto M; Burkart V; Mathieu C; Kolb H; Diabetes Research Institute, Heinrich-Heine University,; Dusseldorf, Germany. helga.rothe@lrz.uni-muenchen.de; The development of type 1 diabetes in animal models is T cell and macrophage dependent. Islet inflammation begins as peripheral benign Th2 type insulitis and progresses to destructive Th1 type insulitis, which is driven by the innate immune system via secretion of IL-12 and IL-18. We now report that daily application
HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system.: J Immunol. 1999 Aug 1;163(3):1237-45. Unique Identifier : AIDSLINE MED/99343729; Koedel U; Kohleisen B; Sporer B; Lahrtz F; Ovod V; Fontana A; Erfle V; Pfister HW; Department of Neurology, Klinikum Grosshadern,; Ludwig-Maximilians-University of Munich, Germany.; Recombinant HIV-1 Nef protein, but not Tat, gp120, and gp160, provoked leukocyte recruitment into the CNS in a rat model. The strong reduction of bioactivity by heat treatment of Nef, and the blocking effect of the mAb 2H12, which recognizes the carboxy-terminal amino acid (aa) residues 171-190 (but not of mAb 3E6, an
Distinct in vivo and in vitro cytokine profiles of draining lymph node cells in acute and chronic phases of contact hypersensitivity: importance of a type 2 cytokine-rich cutaneous milieu for the development of an early-type response in the chronic phase.: J Immunol. 1999 Aug 1;163(3):1265-73. Unique Identifier : AIDSLINE MED/99343733; Kitagaki H; Kimishima M; Teraki Y; Hayakawa J; Hayakawa K; Fujisawa S; Shiohara T; Department of Dermatology, Kyorin University School of Medicine,; Tokyo, Japan.; Although regional lymph nodes (LN) have been extensively studied as rich sources of effector T cells in contact hypersensitivity (CH), it remains unknown whether T cell responses in the LN reflect those in effector skin sites. We previously showed that repeated elicitation of CH results in a shift in the time course o
Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro.: J Immunol. 1999 Aug 1;163(3):1298-305. Unique Identifier : AIDSLINE MED/99343737; Chai JG; Vendetti S; Bartok I; Schoendorf D; Takacs K; Elliott J; Lechler R; Dyson J; Department of Immunology, Division of Medicine, Medical Research; Council Clinical Sciences Centre, Imperial College School of; Medicine, London, United Kingdom.; The influence of costimulation on the activation of naive CD8+ T cells and thymocytes was studied in vitro using H-Y-specific TCR-transgenic mice and H-Y antigenic peptide. Using a variety of physiological APC types, the activation of naive CD8+ T cells depended strictly on costimulation, which could not be substitute
Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake.: J Immunol. 1999 Aug 1;163(3):1398-408. Unique Identifier : AIDSLINE MED/99343750; Todryk S; Melcher AA; Hardwick N; Linardakis E; Bateman A; Colombo MP; Stoppacciaro A; Vile RG; Imperial Cancer Research Fund Laboratory of Molecular Therapy,; Imperial Cancer Research Fund Oncology Unit, Imperial College of; Science and Medicine, Hammersmith Hospital, London, United; Kingdom.; Previously, we reported that killing tumor cells in vivo with the HSV thymidine kinase/ganciclovir system generates potent antitumor immunity, determined in part by the mechanism by which the cells die and by the levels of inducible heat shock protein (hsp) expression induced during the process of cell death. Here, we
IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients.: J Immunol. 1999 Aug 1;163(3):1420-7. Unique Identifier : AIDSLINE MED/99343752; Rouleau M; Cottrez F; Bigler M; Antonenko S; Carballido JM; Zlotnik A; Roncarolo MG; Groux H; DNAX Research Institute, Palo Alto, CA 94304, USA.; To analyze the effect of IL-10 overexpressed by APCs as observed in some SCID patients, we have expressed the human IL-10 cDNA under the control of the murine MHC class II promoter in transgenic mice. Similar to SCID patients, these mice presented a defect in T cell maturation characterized by a rapid thymic aplasia t
A novel CD8 T cell-restricted CD45RB epitope shared by CD43 is differentially affected by glycosylation.: J Immunol. 1999 Aug 1;163(3):1441-8. Unique Identifier : AIDSLINE MED/99343755; Carlow DA; Ardman B; Ziltener HJ; The Biomedical Research Centre, University of British Columbia,; Vancouver, Canada.; The mAb 1B11 has been characterized as recognizing the activation-associated glycoform of murine CD43, a heavily O-glycosylated protein implicated in leukocyte homing. When hemopoietic cells from CD43-/- mice were stained with 1B11, CD43-independent binding of 1B11 was observed on peripheral CD8 T cells and at low lev
Th1 T cell responses to HIV-1 Gag protein delivered by a Listeria monocytogenes vaccine are similar to those induced by endogenous listerial antigens.: J Immunol. 1999 Aug 1;163(3):1449-56. Unique Identifier : AIDSLINE MED/99343756; Mata M; Paterson Y; Department of Microbiology, University of Pennsylvania Medical; School, Philadelphia 19104, USA.; Listeria monocytogenes is a facultative intracellular bacterium that lives and grows in the cytoplasm of the host cell. The hallmark of a listerial infection is a cell-mediated immune response to its own secreted virulence factors. Thus, L. monocytogenes vaccines engineered to secrete HIV proteins may be ideal vectors
Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infection.: J Immunol. 1999 Aug 1;163(3):1481-9. Unique Identifier : AIDSLINE MED/99343760; Coppola MA; Flano E; Nguyen P; Hardy CL; Cardin RD; Shastri N; Woodland DL; Blackman MA; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; Like EBV-infected humans with infectious mononucleosis, mice infected with the rodent gammaherpesvirus MHV-68 develop a profound increase in the number of CD8+ T cells in the circulation. In the mouse model, this lymphocytosis consists of highly activated CD8+ T cells strikingly biased toward V beta 4 TCR expression.
Infection of HIV-1 transgenic mice with Mycobacterium avium induces the expression of infectious virus selectively from a Mac-1-positive host cell population.: J Immunol. 1999 Aug 1;163(3):1506-15. Unique Identifier : AIDSLINE MED/99343763; Doherty TM; Chougnet C; Schito M; Patterson BK; Fox C; Shearer GM; Englund G; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, Bethesda, MD 20892,; USA.; Infection of HIV-1-transgenic mice with Mycobacterium avium, a common opportunistic pathogen in AIDS patients, was shown to result in increased tissue expression of viral specific transcripts. Moreover, by coculturing splenocytes from the transgenic animals with human T cells it was possible to demonstrate that the el
Essential role of T cell NF-kappa B activation in collagen-induced arthritis.: J Immunol. 1999 Aug 1;163(3):1577-83. Unique Identifier : AIDSLINE MED/99343772; Seetharaman R; Mora AL; Nabozny G; Boothby M; Chen J; Department of Medicine, Vanderbilt University, Nashville, TN; 37232, USA.; NF-kappa B/Rel proteins are ubiquitous transcription factors that are activated by proinflammatory signals or engagement of Ag receptors. To study the role of NF-kappa B/Rel signaling in T lymphocytes during autoimmune disease, we investigated type II collagen-induced arthritis (CIA) in transgenic mice expressing a co
Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.: J Immunol. 1999 Aug 1;163(3):1636-46. Unique Identifier : AIDSLINE MED/99343779; Klein RS; Williams KC; Alvarez-Hernandez X; Westmoreland S; Force T; Lackner AA; Luster AD; AIDS Research Center, Massachusetts General Hospital, Harvard; Medical School, Charlestown 02129, USA.; klein.robyn@mgh.harvard.edu; Chemokines are believed to play a role in the neuropathogenesis of AIDS through their recruitment of neurotoxin-secreting, virally infected leukocytes into the CNS. Levels of chemokines are elevated in brains of patients and macaques with HIV/SIV-induced encephalitis. The chemokine receptors CCR3, CCR5, and CXCR4 are
Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy.: J Immunol. 1999 Aug 1;163(3):1666-73. Unique Identifier : AIDSLINE MED/99343783; Chougnet C; Cohen SS; Kawamura T; Landay AL; Kessler HA; Thomas E; Blauvelt A; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; Bethesda, MD 20892, USA.; Dendritic cells (DC) are the most potent cells involved in the generation of primary and secondary immune responses. To assess the feasibility of using autologous DC as immunotherapy for HIV disease, we analyzed a variety of immune parameters using DC isolated from HIV-infected (HIV+) individuals, as well as DC obtain
Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse.: J Immunol. 1999 Aug 1;163(3):1696-703. Unique Identifier : AIDSLINE MED/99343787; Gallichan WS; Balasa B; Davies JD; Sarvetnick N; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.; When immunological tolerance breaks down, autoimmune destruction of insulin-producing beta cells in the pancreas can cause insulin-dependent diabetes mellitus. We previously showed that transgenic nonobese diabetic (NOD) mice expressing IL-4 in the pancreas (NOD-IL-4 mice) were protected from insulitis and diabetes. H
What's new in HIV.: J Infect. 1999 Mar;38(2):i-ii. Unique Identifier : AIDSLINE MED/99272069; Morris-Jones S; Nelson MR
How I encourage my patients to take their antiretroviral therapy regularly.: J Infect. 1999 Mar;38(2):ii. Unique Identifier : AIDSLINE MED/99272070; Walsh J; Chelsea & Westminster Hospital, London.
Epidemiology and outcome of HIV infection in North-East Scotland (1985-1997).: J Infect. 1999 Mar;38(2):107-10. Unique Identifier : AIDSLINE MED/99272078; Mackenzie AR; Laing RB; Urbaniak SJ; Molyneaux PJ; Douglas JG; Smith CC; The Infection Unit, Aberdeen Royal Infirmary, Scotland, UK.; OBJECTIVE: to assess the epidemiology of HIV infection in North-East Scotland. METHODS: retrospective casenote review of all HIV-infected patients who have had contact with the Infection Unit in Aberdeen. RESULTS: one hundred and forty-two HIV-infected patients were treated between April 1985 and December 1997. The ri
Desensitization to co-trimoxazole (trimethoprim-sulphamethoxazole) in HIV-infected patients: is patch testing a useful predictor of reaction?: J Infect. 1999 Mar;38(2):111-5. Unique Identifier : AIDSLINE MED/99272079; Gompels MM; Simpson N; Snow M; Spickett G; Ong E; Department of Immunology, Southmead Hospital, Bristol, UK.; OBJECTIVE: To establish the safety and efficacy of desensitization to co-trimoxazole in hypersensitive HIV-infected subjects. To assess if delayed hypersensitivity (type IV) to co-trimoxazole predicts those unable to be desensitized. METHOD: desensitization to co-trimoxazole, comprising trimethoprim (T) 0.4 mg and sul
Long-term non-progression in HIV infection: clinico pathological issues.: J Infect. 1999 Mar;38(2):67-70. Unique Identifier : AIDSLINE MED/99272071; Rowland-Jones S; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, UK.
Long-term non-progression in HIV infection: definitions and epidemiological issues.: J Infect. 1999 Mar;38(2):71-3. Unique Identifier : AIDSLINE MED/99272072; Easterbrook PJ; Department of HIV and Genitourinary Medicine, Guy's, King's and; St. Thomas' School of Medicine, King's College Hospital, London,; UK.
The tuberculosis pandemic--which way now?: J Infect. 1999 Mar;38(2):74-9. Unique Identifier : AIDSLINE MED/99272073; Zumla A; Mwaba P; Squire SB; Grange JM; Centre for Infectious Diseases, Royal Free and University College; Medical School, London, UK.
Diagnostic usefulness of percutaneous liver biopsy in HIV-infected patients with fever of unknown origin.: J Infect. 1999 Mar;38(2):94-8. Unique Identifier : AIDSLINE MED/99272076; Garcia-Ordonez MA; Colmenero JD; Jimenez-Onate F; Martos F; Martinez J; Juarez C; Departmento de Medicina Interna, Complejo Hospitalario; Universitario Carlos Haya, Malaga, Spain.; OBJECTIVES: to determine the value of percutaneous liver biopsy (PLB) in the diagnosis of fever of unknown origin (FUO) in HIV-infected patients and establish a prediction model for its usefulness to enable diagnosis of FUO in these patients to be standardized. METHODS: a total of 58 HIV-infected patients who underwen
Mitigation of delayed-type hypersensitivity reactions by a CD44 variant isoform v3-specific antibody: blockade of leukocyte egress.: J Invest Dermatol. 1999 Jul;113(1):11-21. Unique Identifier : AIDSLINE MED/99348665; Seiter S; Engel P; Fohr N; Zoller M; Department of Tumor Progression and Immune Defense, German Cancer; Research Center, Heidelberg.; In allergic alterations of human skin the majority of infiltrated leukocytes express CD44v3, but no other CD44 variant isoform. Vessel endothelium, too, is brightly stained with a CD44v3-specific antibody. Being concerned about therapeutic intervention, it became of importance to define whether expression of CD44v3 on
Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice.: J Invest Dermatol. 1999 Jul;113(1):61-8. Unique Identifier : AIDSLINE MED/99348673; Freyschmidt-Paul P; Sundberg JP; Happle R; McElwee KJ; Metz S; Boggess D; Hoffmann R; Department of Dermatology, Philipp University, Marburg, Germany.; A type of hair loss closely resembling human alopecia areata has been described in C3H/HeJ mice. In order to test the assumed analogy with human alopecia areata, we investigated the efficacy of treatment with the contact allergen squaric acid dibutylester. In 12 C3H/HeJ mice with alopecia areata an allergic contact de
A mixed model for factors predictive of pain in AIDS patients with herpes zoster.: J Pain Symptom Manage. 1999 Jun;17(6):410-7. Unique Identifier : AIDSLINE MED/99314301; Harrison RA; Soong S; Weiss HL; Gnann JW Jr; Whitley RJ; Biostatistics Unit, University of Alabama at Birmingham; 35294-3300, USA.; A unifying model of herpes zoster pain presents considerable analytical challenges due to the requirement for prospective data collection and the varying rates of pain resolution reported by individual patients. Demographic, clinical, and quality-of-life measures were collected on 166 human immunodeficiency virus (HIV
Pathogenesis of simian immunodeficiency virus infection.: J Gen Virol. 1999 Jul;80 ( Pt 7):1557-68. Unique Identifier : AIDSLINE MED/99349985; Whetter LE; Ojukwu IC; Novembre FJ; Dewhurst S; Department of Microbiology and Immunology, University of; Rochester Medical Center, NY 14642, USA.
Beta-chemokine production in macaques vaccinated with live attenuated virus correlates with protection against simian immunodeficiency virus (SIVsm) challenge.: J Gen Virol. 1999 Jul;80 ( Pt 7):1569-74. Unique Identifier : AIDSLINE MED/99349986; Ahmed RK; Nilsson C; Wang Y; Lehner T; Biberfeld G; Thorstensson R; Swedish Institute for Infectious Disease Control, Solna.; raija.ahmed@smi.ki.se; Simian immunodeficiency virus (SIV) uses the CCR5 chemokine receptor as the main co-receptor to enter CD4+ cells. RANTES, MIP-1alpha and MIP-1beta have been suggested as the major human immunodeficiency virus-suppressor factors produced by CD8+ T-cells. The aim of this study was to investigate the CD8+ T-cell producti
Differential response to genotoxic stress in immortalized or transformed human T-lymphotropic virus type I-infected T-cells.: J Gen Virol. 1999 Jul;80 ( Pt 7):1575-81. Unique Identifier : AIDSLINE MED/99349987; Cereseto A; Kislyakova T; Washington Parks R; Nicot C; Franchini G; Basic Research Laboratory, Division of Basic Sciences, National; Cancer Institute, National Institutes of Health, Bethesda, MD; 20892, USA.; Several alterations in the mechanism of cell cycle control have been observed in human T-lymphotropic virus type I (HTLV-I)-infected cells. Here, it is reported that HTLV-I-infected cells both in their immortalized and transformed phase do not undergo apoptosis following ionizing radiation (IR) treatment. However, whe
Differential cytokine responses of CD4+ and CD8+ T cells in response to bovine viral diarrhoea virus in cattle.: J Gen Virol. 1999 Jul;80 ( Pt 7):1673-9. Unique Identifier : AIDSLINE MED/99349998; Rhodes SG; Cocksedge JM; Collins RA; Morrison WI; Institute for Animal Health, Newbury, Berkshire, UK.; srhodes.vla@gtnet.gov.uk; Virus-specific T cell responses were measured in cattle seropositive for bovine viral diarrhoea virus (BVDV) and compared with those from BVDV-seronegative animals. CD4+ and CD8+ T cells were purified and co-cultured in vitro with autologous, BVDV-infected monocytes over a time-course to assess the kinetics of the pro
Prevalence and mother-to-infant transmission of hepatitis viruses B, C, and E in Southern Tanzania.: J Med Virol. 1999 Jul;58(3):215-20. Unique Identifier : AIDSLINE MED/99314986; Menendez C; Sanchez-Tapias JM; Kahigwa E; Mshinda H; Costa J; Vidal J; Acosta C; Lopez-Labrador X; Olmedo E; Navia M; Tanner M; Rodes J; Alonso PL; Unidad de Epidemiologia y Bioestadistica, Institut; d'Investigacions Biomedicas August Pi i Sunyer (IDIBAPS),; Hospital Clinic, Barcelona, Spain. cmenende@medicina.ub.es; Hepatitis B and C markers were tested in 980 pregnant women, in the infants born to infected mothers, and in a random sample of 42 and 50, respectively, children born to uninfected mothers in Tanzania . Sixty-two women (6.3%) were positive for HBsAg and 15 (24%) were HBeAg-seropos
Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hypervariable region 1 and interferon sensitivity determining region.: J Med Virol. 1999 Jul;58(3):247-55. Unique Identifier : AIDSLINE MED/99314991; Hashimoto M; Chayama K; Kobayashi M; Tsubota A; Arase Y; Saitoh S; Suzuki Y; Ikeda K; Matsuda M; Koike H; Kobayashi M; Handa H; Kumada H; Liver Research Laboratory, Toranomon Hospital, Kanagawa, Japan.; Hepatitis C virus (HCV) load is one of the most important predictive factors of response to interferon treatment. However, little is known about the mode and determinants of viremia. The mode of viremia was investigated in 78 patients with chronic HCV genotype 1b infection during 1-2 years follow up. Virus load, deter
Status of long-term asymptomatic HIV-1 infection correlates with viral load but not with virus replication properties and cell tropism. French ALT Study Group.: J Med Virol. 1999 Jul;58(3):256-63. Unique Identifier : AIDSLINE MED/99314992; Candotti D; Costagliola D; Joberty C; Bonduelle O; Rouzioux C; Autran B; Agut H; Laboratoire de Virologie EA 2387, CERVI, Hopital; Pitie-Salpetriere, Paris, France.; Qualitative and quantitative virological parameters were investigated in 68 long-term nonprogressor (LTNP) HIV-1-infected patients and 9 slow-progressor controls. LTNP status was defined as an asymptomatic HIV infection for at least 8 years, a stability of CD4+ cell counts > or =600 cells/mm3 and no antiretroviral the
Transiently transfected and stably integrated HIV-1 LTR responds differentially to the silencing activity of the Kruppel-associated box (KRAB) transcriptional repressor domain.: Unique Identifier : AIDSLINE MED/99314993; Rossi C; Gibellini D; Barbanti-Brodano G; Betti M; Boarini C; Pengue G; Lania L; Caputo A; It has been demonstrated previously that the transcriptional repressor domain called the Kruppel-associated box (KRAB), conserved in a large number of Kruppel-type zinc finger proteins, fused to Tat transdominant negative mutants, is able to silence HIV-1 long terminal repeat (LTR)-driven gene expression in transient
Maintenance of high-avidity rubella-specific IgG antibody and titres in recent HIV seroconvertors and in patients progressing to the AIDS-related complex and AIDS.: Unique Identifier : AIDSLINE MED/99314994; Thomas HI; Aird HC; The avidity (functional affinity) and titre of rubella-specific IgG antibodies were examined in sequential and cross-sectional
Shorter survival in HIV-positive patients with diarrhoea who excrete adenovirus from the GI tract.: J Med Virol. 1999 Jul;58(3):280-5. Unique Identifier : AIDSLINE MED/99314995; Sabin CA; Clewley GS; Deayton JR; Mocroft A; Johnson MA; Lee CA; McLaughlin JE; Griffiths PD; Department of Primary Care and Population Sciences, Royal Free; and University College Medical School, London, England.; caroline@rfhsm.ac.uk; Adenoviruses have been described as a cause of diarrhoea in patients infected with the human immunodeficiency virus (HIV). The prevalence of adenoviruses was studied in all HIV-positive patients presenting with diarrhoea at the Royal Free Hospital in London between 1991 and 1995. In addition, all postmortems carried o
Evaluation of serological screening of cadaveric sera for donor selection for cornea transplantation.: J Med Virol. 1999 Jul;58(3):291-5. Unique Identifier : AIDSLINE MED/99314997; Heim A; Wagner D; Rothamel T; Hartmann U; Flik J; Verhagen W; Institut fur Virologie und Seuchenhygiene, Medizinische; Hochschule Hannover, Germany. ahei@virologie.mh-hannover.de; Human corneas are explanted for grafting as late as 72 h after death, for example, from medical examiner cases. Currently, infection of the donor with human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) is excluded in most cornea banks by serological testing of the cadaveric serum
Rapid diagnosis of cryptococcal meningitis by microscopic examination of centrifuged cerebrospinal fluid sediment.: Unique Identifier : AIDSLINE MED/99311777; Sato Y; Osabe S; Kuno H; Kaji M; Oizumi K; The classic India ink test is positive in only half of cryptococcal meningitis cases, and reliable, rapid cryptococcal antigen (CRAG) testing requires technical expertise and facilities not always available. We therefore examined cerebrospinal fluid (CSF) sediment using May-Giemsa,
Mutational analysis of Phe160 within the "palm" subdomain of human immunodeficiency virus type 1 reverse transcriptase.: J Mol Biol. 1999 Jul 16;290(3):615-25. Unique Identifier : AIDSLINE MED/99326775; Gutierrez-Rivas M; Ibanez A; Martinez MA; Domingo E; Menendez-Arias L; Centro de Biologia Molecular "Severo Ochoa", CSIC-Universidad; Autonoma de Madrid, Cantoblanco 28049, Spain.; The highly conserved Phe160 residue is located in the palm subdomain of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), and makes contact with Tyr115, a residue which is involved in deoxynucleoside triphosphate (dNTP) binding and fidelity of DNA synthesis. Five mutant RTs having Tyr, Trp, Ile
A preliminary study of African-American physician involvement in the care of HIV-infected patients.: J Natl Med Assoc. 1999 Jun;91(6):343-8. Unique Identifier : AIDSLINE MED/99314315; Rawlings MK; Grimes RM; Easling I; Community-Oriented Primary Care Program, Parkland Health and; Hospital System, Department of Internal Medicine, University of; Texas Southwestern Medical School, Dallas, USA.; In 1995, questionnaires were sent to the mailing list of the National Medical Association (NMA). The mail responses were supplemented by questionnaires distributed at the NMA annual meeting. Of the 709 respondents, approximately 63% were primary care providers, pediatricians, or obstetrician-gynecologists; 72% were tr
Emerging and re-emerging infectious diseases in Korea.: Kao Hsiung I Hsueh Ko Hsueh Tsa Chih. 1999;15 Suppl:S46-50. Unique Identifier : AIDSLINE MED/99351322; Kim JS; School of Public Health, Seoul National University, Korea.
HIV/AIDS prevention and care program in Thailand: interventions in action.: Kao Hsiung I Hsueh Ko Hsueh Tsa Chih. 1999;15 Suppl:S62-4. Unique Identifier : AIDSLINE MED/99351325; Thanprasertsuk S; Department of Communicable Diseases, Ministry of Public Health,; Thailand.
[Meeting of the Pediatric Work Group AIDS in Germany (PAAD) on May 8-9, 1998 in Frankfurt/Main (news)]: Klin Padiatr. 1999 Mar-Apr;211(2):96-7. Unique Identifier : AIDSLINE MED/99336158; Funk M
[Combined polychemotherapy of patients with chronic hepatitis C]: Klin Med (Mosk). 1999;77(5):24-6. Unique Identifier : AIDSLINE MED/99323094; Nikitin IG; Storozhakov GI; Kuznetsov SL; Strochenovskii AB
[A study on fall accident]: Taehan Kanho. 1997 Nov-Dec;36(5):45-62. Unique Identifier : AIDSLINE MED/99366658; Lee HS; Kim MJ; The study was conducted from November 1995 to May 1996 at the one general hospital in Seoul. The total subjects of this study were 412 patients who have the experience of fall accident, among them 31 was who have fallen during hospitalization and 381 was who visited emergency room and out patient clinic. The purposes
Short-term impact of safer choices: a multicomponent, school-based HIV, other STD, and pregnancy prevention program.: J Sch Health. 1999 May;69(5):181-8. Unique Identifier : AIDSLINE MED/99291400; Coyle K; Basen-Engquist K; Kirby D; Parcel G; Banspach S; Harrist R; Baumler E; Weil M; ETR Associates, Santa Cruz, CA 95061-1830, USA.; This study evaluated the effectiveness of the first year of Safer Choices, a theoretically based, multicomponent HIV, STD, and pregnancy prevention program for high school youth. The study featured a randomized trial involving 20 schools in California and Texas, with a cohort of 3,869 ninth-grade students. Students wh
[Evaluation of the law of communicable disease control: compulsory isolation can reduce the high-risk behavior of HIV-positive individuals]: Lakartidningen. 1999 Jul 14;96(28-29):3244-7. Unique Identifier : AIDSLINE MED/99363351; Sylvan S; Gustavsson M; Christenson B; Karolinska sjukhuset, Stockholm. staffan.sylvan@sme.sll.se; The Swedish approach to HIV is based on HIV-positive individuals fulfilling their societal obligation to prevent further spread of the disease. Under section 38 of the Communicable Disease Act of 1989, compulsory admission to hospital may be resorted to in cases where voluntary efforts have failed to bring about modi
"Inactive" polymer is active against sexually transmitted diseases [news]: Lancet. 1999 Jul 31;354(9176):399. Unique Identifier : AIDSLINE MED/99364591; Larkin M
Glycoscience moves from the laboratory to the clinic [news]: Lancet. 1999 Jul 31;354(9176):402. Unique Identifier : AIDSLINE MED/99364592; Rowe PM
Inquiries launched after Australian girl contracts HIV from blood transfusion [news]: Lancet. 1999 Jul 31;354(9176):404. Unique Identifier : AIDSLINE MED/99364594; Loff B; Cordner S
Japan tackles sexually transmitted diseases [news]: Lancet. 1999 Jul 31;354(9176):405. Unique Identifier : AIDSLINE MED/99364595; Watts J
Vaccines for smallpox [letter]: Lancet. 1999 Jul 31;354(9176):422. Unique Identifier : AIDSLINE MED/99364602; Blanchard T; Smith GL; Whittle H
The retrotransposon Osvaldo from Drosophila buzzatii displays all structural features of a functional retrovirus.: Mol Biol Evol. 1999 Jul;16(7):909-21. Unique Identifier : AIDSLINE MED/99334611; Pantazidis A; Labrador M; Fontdevila A; Departament de Genetica i de Microbiologia, Universitat; Autonoma de Barcelona, Spain.; The Osvaldo retrotransposon has shown a high transposition rate in some strains of Drosophila buzzatii and in hybrids between D. buzzatii and its sibling D. koepferae. In order to understand the molecular basis of this phenomenon, we developed a procedure to clone a recently transposed copy with the aim of characteriz
The mid-depth method and HIV-1: a practical approach for testing hypotheses of viral epidemic history.: Mol Biol Evol. 1999 Jul;16(7):953-9. Unique Identifier : AIDSLINE MED/99334615; Pybus OG; Holmes EC; Harvey PH; Department of Zoology, University of Oxford, United Kingdom.; oliver.pybus@zoo.ox.ac.uk; We introduce the mid-depth method, a practical approach for testing hypotheses of demographic history using genealogies reconstructed from sequence data. The relative positions of internal nodes within a genealogy contain information about past population dynamics. We explain how this information can be used to (1) te
Free radical spin traps as adjuncts for the prevention and treatment of disease.: Med Hypotheses. 1999 Jan;52(1):53-7. Unique Identifier : AIDSLINE MED/99272100; Anderson KM; Ells G; Bonomi P; Harris JE; Department of Medicine, Rush Medical College, Chicago, IL, USA.; Free radical spin traps exhibit properties consistent with a role in the prevention or amelioration of diseases mediated by the formation of free radical species in excess of optimum constitutive requirements. At first view, it may be surprising that they have not found a place in clinical medicine. Some studies of di
How HIV-1 lentivirus causes immune deficiency disease.: Med Hypotheses. 1999 Jan;52(1):59-67. Unique Identifier : AIDSLINE MED/99272101; Habeshaw JA; Wilson SE; Hounsell EF; Oxford JS; Department of Medical Microbiology, St Bartholomew's and the; Royal London School of Medicine & Dentistry, Whitechapel, UK.; Human immunodeficiency virus (HIV-1) associated immune deficiency has the characteristics of chronic graft versus host disease (GVHD) caused by human leukocyte antigen (HLA) class 2 incompatibility. The envelope glycoprotein fragment TKAKRRVVEREKR mimics HLA class 1 C molecules serologically, and also mimics an immune
HIV pathogenesis: gp120-antibody complexes bind CD4 and kill T4 cells--immunotoxin therapy should prevent the progression of HIV to AIDS.: Med Hypotheses. 1999 Feb;52(2):133-46. Unique Identifier : AIDSLINE MED/99271653; Chaplin JW; Santa Cruz AIDS Research Foundation, CA 95061, USA.; scarf@scarf.org; Current models of the role of human immunodeficiency virus (HIV) in the pathogenesis of acquired immune deficiency syndrome (AIDS) are inadequate and inconsistent with the literature. This article reviews a wide range of AIDS research and proposes the first model of HIV pathogenesis that is entirely consistent with th
The need to revise the Declaration of Helsinki.: N Engl J Med. 1999 Aug 12;341(7):531-4. Unique Identifier : AIDSLINE MED/99353513; Levine RJ; Yale University School of Medicine, New Haven, CT 06520, USA.
['Methadone substitution therapy and driving'. Results of an experimental study]: Nervenarzt. 1999 May;70(5):457-62. Unique Identifier : AIDSLINE MED/99336180; Dittert S; Naber D; Soyka M; Psychiatrische Klinik, Universitat Munchen.; The aim of our experimental study was to gain informations and data on the driving ability of patients undergoing a methadone substitution programme as well as to explore the influence of an HIV infection. 28 patients, five of them HIV-positive, were compared to a control group equal in age, sex and education. For the
[Prevalence of HIV infection in dialysis patients: results of a national multicenter study]: Nephrologie. 1999;20(3):159-63. Unique Identifier : AIDSLINE MED/99346560; Poignet JL; Desassis JF; Chanton N; Litchinko MB; Zins B; Kolko A; Patte R; Sobel A; Clinique medicale Edouard Rist, Paris.; In order to determine the prevalence of HIV infection in french patients with end-stage renal disease (ESRD) on maintenance dialysis therapy, questionnaire forms were mailed out in february 1997 to the heads of the 260 dialysis facilities. We documented number of patients on maintenance dialysis therapy (hemo and peri
A case of unpaired anterior cerebral artery occlusion producing akinetic mutism [letter]: Neurol India. 1999 Jun;47(2):157-8. Unique Identifier : AIDSLINE MED/99330800; Oomman A; Madhusudhanan M
Distinct light microscopic changes in HIV-associated nemaline myopathy [letter]: Neurology. 1999 Jul 13;53(1):241-2. Unique Identifier : AIDSLINE MED/99335064; Miro O; Grau JM; Pedrol E
Live virus survives excimer laser ablation.: Ophthalmology. 1999 Aug;106(8):1498-9. Unique Identifier : AIDSLINE MED/99369523; Taravella MJ; Weinberg A; May M; Stepp P; Department of Ophthalmology, University of Colorado Health; Sciences Center, Denver, USA. Michael.Taravella@uchsc.edu; OBJECTIVES: To determine whether live virus can withstand excimer laser ablation and pose a possible health hazard to medical personnel. DESIGN: Experimental study. METHODS: Fibroblasts infected with oral polio vaccine virus were ablated with an excimer laser. The plume was collected using a smoke evacuator and bubble
Use of the polymerase chain reaction for diagnosis of ocular toxoplasmosis.: Ophthalmology. 1999 Aug;106(8):1554-63. Unique Identifier : AIDSLINE MED/99369534; Montoya JG; Parmley S; Liesenfeld O; Jaffe GJ; Remington JS; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, Research Institute, California 94301, USA.; OBJECTIVE: To report a cohort of patients in whom polymerase chain reaction (PCR) was performed on vitreous samples and to place in perspective the current role of PCR in the diagnosis of ocular toxoplasmosis. DESIGN: Noncomparative case series. PARTICIPANTS: Fifteen patients in whom toxoplasmic retinochoroiditis was
Medical consequences of substance abuse.: Psychiatr Clin North Am. 1999 Jun;22(2):351-70. Unique Identifier : AIDSLINE MED/99313716; Stein MD; Rhode Island Hospital, Department of Medicine, Providence, Rhode; Island, USA.; Given the preceding review, differentiating the complications of parenteral drug use, HIV disease, and the toxicity of the drugs such as alcohol or cocaine may be a difficult matter for clinicians. The risk for coexisting morbidities is high. Thus, obtaining accurate and complete medical histories is of paramount impo
AIDS knowledge among black drug users: an issue of reliability.: Psychol Rep. 1999 Feb;84(1):121-4. Unique Identifier : AIDSLINE MED/99220137; Wang MQ; Collins CB; Kohler CL; DiClemente RJ; Wingood Gf3p4; University of Alabama, USA. mwang@bamaed.ua.edu; This study examined the reliability of an inventory measuring AIDS-related knowledge among 553 black drug users. Data were collected from a socially high-risk community in Birmingham, Alabama. The KR-20 reliability scores were computed from the inventory for each drug-use group. The KR-20 reliabilities ranged from .39
Executive functioning and compliance in HIV patients.: Psychol Rep. 1999 Feb;84(1):319-22. Unique Identifier : AIDSLINE MED/99220170; Mann LS; Westlake T; Wise TN; Beckman A; Beckman P; Portez D; Department of Psychiatry, Inova Fairfax Hospital, Falls Church,; VA 22042, USA. Lee.Mann@Inova.com; 25 adult HIV patients were evaluated in a study of appointments, medication, and compliance with restrictions on sexual activity. The Executive Interview (EXIT) was useful in assessing these patients for cognitive difficulties; compliance with medication and countertransference issues were negatively correlated with E
[Knowledge, beliefs and attitudes of inmates towards AIDS and HIV infection: a survey in a Marseille penitentiary center]: Rev Epidemiol Sante Publique. 1999 Jun;47(3):229-38. Unique Identifier : AIDSLINE MED/99351017; Delorme C; Rotily M; Escaffre N; Galinier-Pujol A; Loundou A; Moatti JP; Observatoire Regional de la Sante Provence-Alpes-Cote d'Azur,; Marseille, France.; BACKGROUND: The objectives of our study were to evaluate knowledge, attitudes and beliefs of inmates toward HIV infection, and to compare them with those reported in the general population and according to injecting drug use. METHODS: Three hundred and seventy persons incarcerated in the prison of Marseille were invit
Is the AIDS incubation time changing? A back-calculation approach.: Stat Med. 1999 May 15;18(9):1031-47. Unique Identifier : AIDSLINE MED/99306017; Deuffic S; Costagliola D; Unite de Recherche Epidemiologie et Sciences de l'Information; (INSERM U444), Faculte de Medecine Saint-Antoine, Paris,; France.; Contradictory literature was recently published on possible changes in AIDS incubation time over the period 1978-1994. The purpose of this work was to test if a change in incubation time (shortening or lengthening) was observed in France , either globally or in specific transmission
Group testing in presence of classification errors.: Stat Med. 1999 May 15;18(9):1049-68. Unique Identifier : AIDSLINE MED/99306018; Gupta D; Malina R; McMaster University, Michael G. DeGroote School of Business,; Hamilton, Ontario, Canada.; We modify Dorfman s and Sterrett s group testing protocols to make them suitable for testing blood samples for the presence of HIV antibodies, as well as for many industrial applications, when false negatives cannot be tolerated. We first propose that test kit sensitivity be increased to nearly 100 per cent by alterin
Adjusting for measurement error to assess health effects of variability in biomarkers. Multicenter AIDS Cohort Study.: Stat Med. 1999 May 15;18(9):1069-86. Unique Identifier : AIDSLINE MED/99306019; Lyles RH; Munoz A; Xu J; Taylor JM; Chmiel JS; Department of Biostatistics, Rollins School of Public Health,; Emory University, Atlanta, GA 30322, USA.; Longitudinal studies of health effects often relate individuals biomarker levels to disease progression. Repeated measurements also provide an opportunity to assess within-individual biomarker variability, and it is reasonable to postulate that this measure might provide additional information about a particular outc
Interval estimation of the common odds ratio from k(2 x 2) tables under cluster sampling.: Stat Med. 1999 May 15;18(9):1087-100. Unique Identifier : AIDSLINE MED/99306020; Begg MD; Panageas KS; Division of Biostatistics, Columbia School of Public Health, New; York, New York 10032, USA. melissa.begg@columbia.edu; We propose a simple correction factor for the variance of the logarithm of the common odds ratio estimated by the method of Mantel and Haenszel from a series of (2 x 2) tables when data are cluster correlated. The adjustment is applied to the variance estimators proposed by Hauck and by Robins, Breslow and
Deficient cellular immunity--finding and fixing the defects.: Science. 1999 Jul 23;285(5427):546-51. Unique Identifier : AIDSLINE MED/99348489; Greenberg PD; Riddell SR; Fred Hutchinson Cancer Research Center and Departments of; Medicine and Immunology, University of Washington, Seattle, WA; 98195, USA. pgreen@u.washington.edu; The critical role of cellular immunity in resistance to infectious diseases is glaringly revealed by life-threatening infections if T cell function is disrupted by an inherited or acquired immunodeficiency. Although treatment has historically focused on infectious complications, understanding of the cellular and molec
Role of bacterial intimin in colonic hyperplasia and inflammation.: Science. 1999 Jul 23;285(5427):588-91. Unique Identifier : AIDSLINE MED/99348501; Higgins LM; Frankel G; Connerton I; Goncalves NS; Dougan G; MacDonald TT; Department of Paediatric Gastroenterology, St. Bartholomews and; the Royal London School of Medicine and Dentistry, London EC1A; 7BE, UK.; Enteropathogenic Escherichia coli (EPEC) cells adhere to gut epithelial cells through intimin alpha: the ligand for a bacterially derived epithelial transmembrane protein called the translocated intimin receptor. Citrobacter rodentium colonizes the mouse colon in a similar fashion and uses a different intimin: intimin
Beyond the biomedical and behavioural: towards an integrated approach to HIV prevention in the southern African mining industry.: Soc Sci Med. 1999 Jun;48(11):1625-39. Unique Identifier : AIDSLINE MED/99325849; Campbell C; Williams B; Social Psychology, London School of Economics, UK.; c.campbell@lse.ac.uk; While migrant labour is believed to play an important role in the dynamics of HIV-transmission in many of the countries of southern Africa, little has been written about the way in which HIV/AIDS has been dealt with in the industrial settings in which many migrant workers are employed. This paper takes the gold mining
Stories of illness and trauma survival: liberation or repression?: Soc Sci Med. 1999 Jun;48(11):1685-95. Unique Identifier : AIDSLINE MED/99325853; Crossley ML; Edge-Hill University College, Centre for Studies in the Social; Sciences, Ormskirk, Lancashire, UK. crosslem@staff.ehche.ac.uk; This paper aims to expand upon recent research addressing the relationship between power and cultural stories of illness. It does this by exploring the stories of healing and survival produced by people who have undergone traumatic experiences such as childhood sexual abuse and a HIV positive diagnosis. The libera
Implications of social class and race for urban public health policy making: a case study of HIV/AIDS and TB policy in Washington, DC.: Soc Sci Med. 1999 Apr;48(8):1095-102. Unique Identifier : AIDSLINE MED/99316935; Dievler A; Pappas G; US General Accounting Office, Health, Education, and Human; Services Division, Washington, DC 20548, USA.; dievlera.hehs@gao.gov; This paper explores how social class and race affect the public health policy-making process in an urban area. Ethnographic methods were used to collect and analyze information about HIV/AIDS and tuberculosis policy-making by the Washington, DC Commission of Public Health, Kingdon s conceptual model of policy making w
Sexual regimes and sexual networking: the risk of an HIV/AIDS epidemic in Bangladesh.: Soc Sci Med. 1999 Apr;48(8):1103-16. Unique Identifier : AIDSLINE MED/99316936; Caldwell B; Pieris I; Barkat-e-Khuda; Caldwell J; Caldwell P; Health Transition Centre, National Centre for Epidemiology and; Population Health, Australian National University, Canberra, ACT.; 868@nceph.anu.edu.au; Bangladesh adjoins the Asian region with the severest AIDS epidemic and has common borders with two of the most affected areas, the Indian Hill States and northern Burma . There has been disagreement about the danger to Bangladesh, one view
Virus antigen expression and alterations in peripheral blood mononuclear cell subpopulations after classical swine fever virus infection.: Vet Microbiol. 1999 Jun 1;67(1):17-29. Unique Identifier : AIDSLINE MED/99319945; Lee WC; Wang CS; Chien MS; Graduate Institute of Veterinary Pathology, National Chung-Hsing; University, Taichung, Taiwan. wclee@dragon.nchu.edu.tw; Depletion in the number of lymphocytes and viral persistence are thought to be the most important outcomes of classical swine fever virus (CSFV) infection. To define the change in peripheral blood mononuclear cells (PBMC) and virus replication in leukocytes after CSFV infection, 8-week old pigs were infected with the
Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes.: Virus Res. 1999 Apr;60(2):159-69. Unique Identifier : AIDSLINE MED/99319895; Ibrahim J; Griffin P; Coombe DR; Rider CC; James W; Sir William Dunn School of Pathology, University of Oxford, UK.; Many viruses have evolved to exploit cell-surface glycosaminoglycans (GAG), particularly heparan sulfate, to facilitate their attachment and infection of host cells. Here, the case for the involvement of heparan sulfate GAG in cellular infection by human immunodeficiency virus Type 1 (HIV-1) compared with herpes simpl
HIV-1 subtype B in Honduras.: Virus Res. 1999 Apr;60(2):191-7. Unique Identifier : AIDSLINE +; Renjifo B; Blackard JT; Klaskala W; Chaplin BR; Shah P; McLane MF; Barin F; Esparza J; Zelaya JE; Osmanov S; Soto R; Fernandez JA; Baum MK; Essex ME; Harvard School of Public Health, Boston, MA, USA.
Per-contact risk of human immunodeficiency virus transmission between male sexual partners.: Am J Epidemiol. 1999 Aug 1;150(3):306-11. Unique Identifier : AIDSLINE MED/99357305; Vittinghoff E; Douglas J; Judson F; McKirnan D; MacQueen K; Buchbinder SP; Department of Epidemiology and Biostatistics, University of; California San Francisco, 94105, USA.; The risk of human immunodeficiency virus (HIV) transmission from various types of homosexual contact, including oral sex, is of biologic, epidemiologic, and public health importance. The per-contact risk of acquiring HIV infection from specific acts was estimated in a prospective cohort study of 2,189 high-risk homose
Re: "High rates of HIV infection among injection drug users participating in needle exchange programs in Montreal: results of a cohort study" [letter]: Am J Epidemiol. 1999 Aug 1;150(3):325-6. Unique Identifier : AIDSLINE MED/99357309; Garfein RS; Lyerla R; Jones TS; Nakashima AK; Monterroso ER; Vlahov D
A biophenotypic human herpesvirus 8--associated primary bowel lymphoma [letter]: Am J Surg Pathol. 1999 Aug;23(8):992-4. Unique Identifier : AIDSLINE MED/99361925; Beaty MW; Kumar S; Sorbara L; Miller K; Raffeld M; Jaffe ES
Expression of chemokine receptors in the rat brain.: Ann N Y Acad Sci. 1999 Jun 22;876:201-9. Unique Identifier : AIDSLINE MED/99344100; Bajetto A; Bonavia R; Barbero S; Florio T; Costa A; Schettini G; Neuroscience Unit, Advanced Biotechnology Centre, Genova, Italy.; Human immunodeficiency virus (HIV-1) infects the brain and causes a progressive encephalopathy in 20 to 30% of infected children and adults called AIDS dementia complex. Evidence from in vitro and in vivo studies suggests a role for the viral envelope glycoprotein gp120, as a media
Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases.: Ann N Y Acad Sci. 1999 Jun 22;876:229-35. Unique Identifier : AIDSLINE MED/99344103; Panerai AE; Sacerdote P; Bianchi M; Nicoletti F; Manfredi B; Gaspani L; Bartorelli A; Ceciliani F; Ronchi S; Department of Pharmacology, University of Milano, Italy.; panerai@imiucca.csi.unimi.it; UK-114 is a 14-kDa ubiquitous protein recently sequenced by several groups throughout the world. Its activity ranges from being a tumor antigen, a protein synthesis inhibitor or a specific mu-calpain activator. UK-114 shows structural homologies also with proteins of the MHC-1 binding proteins, and heat shock proteins
Rare cause of blindness in a patient with acquired immunodeficiency syndrome.: Ann Otol Rhinol Laryngol. 1999 Jul;108(7 Pt 1):711-4. Unique Identifier : AIDSLINE MED/99362313; Cook MA; Manfredi OL; Masini D; Lopez JJ Jr; Department of Radiology, St Luke's-Roosevelt Hospital Center and; Columbia University College of Physicians and Surgeons, New York,; USA.
["Buffalo neck": an unintended secondary effect of treatment with anti-HIV protease inhibitors]: Ann Dermatol Venereol. 1999 Mar;126(3):254-6. Unique Identifier : AIDSLINE MED/99322744; Milpied-Homsi B; Krempf M; Gueglio B; Raffi F; Stalder JF; Clinique Dermatologique, Hotel-Dieu, Nantes.; BACKGROUND: Lipodystrophy and other fat distribution disorders have been reported in patients receiving protease inhibitor therapy for HIV infection. CASE REPORT: A 50-year-old HIV-positive patient was given protease inhibitor therapy ( indinavir ) for
Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H - imidazole on HCMV DNA replication and permissive infection.: Antiviral Res. 1999 Apr;41(3):101-11. Unique Identifier : AIDSLINE MED/99251761; Johnson RA; Huong SM; Huang ES; Department of Microbiology and Immunology, Lineberger; Comprehensive Cancer Center, University of North Carolina, Chapel; Hill, NC 27599-7295, USA.; We found that Human Cytomegalovirus (HCMV) infection of human fibroblasts resulted in a dramatic increase in p38 mitogen-activated protein kinase (MAPK) phosphorylation. Recently, drug mediated inhibition of p38 has been demonstrated to exhibit anti-viral activity against HIV (Shapiro, L., Heidenreich, K.A., Meintzer,
Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir.: Antiviral Res. 1999 Apr;41(3):113-8. Unique Identifier : AIDSLINE MED/99251762; Oon CJ; Chen WN; Lim N; Koh S; Lim GK; Leong AL; Tan GS; Department of Clinical Research, Singapore General Hospital,; Singapore. gcrcwn@sgh.gov.sg; Lamivudine is a new antiviral agent effective against hepatitis B viral (HBV) infections but can result in virus-drug resistance associated with mutations in the conserved YM552DD motif of the HBV DNA polymerase. Due to their overlapping coding regi
Inhibition of HIV-1 replication by newly developed adamantane-containing polyanionic agents.: Antiviral Res. 1999 Apr;41(3):135-44. Unique Identifier : AIDSLINE MED/99251764; Burstein ME; Serbin AV; Khakhulina TV; Alymova IV; Stotskaya LL; Bogdan OP; Manukchina EE; Jdanov VV; Sharova NK; Bukrinskaya AG; D.I. Ivanovsky Institute of Virology, Russian Academy of Medical; Sciences, Moscow.; Newly developed antiviral compounds consisting of an adamantane derivative chemically linked to a water-soluble polyanionic matrix were shown to inhibit HIV-1 infection in lymphoblastoid cells, HeLa CD4+ beta-galactosidase (MAGI) cells and macrophages. The effect of the compounds was recorded by measuring viral revers
Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine.: Antiviral Res. 1999 Jun;42(2):97-108. Unique Identifier : AIDSLINE MED/99316515; Morrey JD; Bailey KW; Korba BE; Sidwell RW; Institute for Antiviral Research, Utah State University, Logan; 84322-5600, USA. jmorrey@cc.usu.edu; A recently developed transgenic mouse strain which expresses high levels of hepatitis B virus (HBV) was studied as a model for evaluation of potential chemotherapeutic agents. Lamivudine ([-]2 -deoxy-3 -thiacytidine), known to reduce hepatitis B virem
HIV-1 Tat protein is poly(ADP-ribosyl)ated in vitro.: Biochem Biophys Res Commun. 1999 Jul 22;261(1):90-4. Unique Identifier : AIDSLINE MED/99335364; Kameoka M; Tanaka Y; Ota K; Itaya A; Yamamoto K; Yoshihara K; Department of Biochemistry, Nara Medical University, Nara,; Kashihara, 634-8521, Japan.; Purified recombinant HIV-1 Tat protein stimulated acceptor-dependent reaction of poly(ADP-ribose) polymerase in a dose-dependent manner. Analysis of the reaction products by SDS-polyacrylamide gel electrophoresis followed by immunoblotting with anti-poly(ADP-ribose) antibody revealed that recombinant Tat proteins were
Interleukin-15 enhances HIV-1-driven polyclonal B-cell response in vitro.: Exp Clin Immunogenet. 1999;16(3):162-72. Unique Identifier : AIDSLINE MED/99323823; Kacani L; Sprinzl GM; Erdei A; Dierich MP; Institut fur Hygiene, Leopold-Franzens-Universitat Innsbruck,; Innsbruck, Osterreich. Laco.Kacani@uibk.ac.at; Interleukin-15 (IL-15) is a recently described cytokine, produced by monocytes/macrophages, with biological activities similar to IL-2 . Since IL-15 was shown to stimulate human B-cell proliferation and immunoglobulin secretion, we investigated its effect on human B-cel
Induction of CD8+ T cell-mediated protective immunity against Trypanosoma cruzi.: Unique Identifier : AIDSLINE MED/99166941; Miyahira Y; Kobayashi S; Takeuchi T; Kamiyama T; Nara T; Nakajima-Shimada J; Aoki T; Trypanosoma cruzi was transformed with the Plasmodium yoelii gene encoding the circum-sporozoite (CS) protein, which contains the well-characterized CD8+ T cell epitope, SYVPSAEQI. In vivo and in vitro assays indicated that cells infected with the transformed T. cruzi could process and present this malaria parasite-de
Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells.: Int Immunol. 1999 Feb;11(2):143-50. Unique Identifier : AIDSLINE MED/99166942; Traber KE; Okamoto H; Kurono C; Baba M; Saliou C; Soji T; Packer L; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, Nagoya, Japan.; NF-kappaB is a potent cellular activator of HIV-1 gene expression. Down-regulation of NF-kappaB activation is known to inhibit HIV replication from the latently infected cells. Gold compounds have been effectively used for many decades in the treatment of rheumatoid arthritis. We previously reported that gold compound
Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by Bacillus Calmette-Guerin vaccination in H-2b mice.: Int Immunol. 1999 Feb;11(2):209-16. Unique Identifier : AIDSLINE MED/99166949; Denis O; Huygen K; Laboratory of Mycobacterial Immunology, Pasteur Institute of; Brussels, Belgium.; Although CD8+ T cells are supposed to play an important role in protective immunity to mycobacteria, cytotoxic T lymphocyte (CTL) responses in this infection remain poorly characterized. We previously demonstrated that bacillus Calmette-Guerin (BCG) immunization of H-2b mice induced CTL able to recognize and kill macr
Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones.: Int Immunol. 1999 Feb;11(2):229-41. Unique Identifier : AIDSLINE MED/99166951; Posnett DN; Edinger JW; Manavalan JS; Irwin C; Marodon G; Graduate School of Medical Sciences, and the Department of; Medicine, Cornell University, Weill Medical College, New York, NY; 10021, USA.; CD8 T cells contain a distinct subset of CD8+ CD28- cells. These cells are not present at birth and their frequency increases with age. They frequently contain expanded clones using various TCRalphabeta receptors and these clones can represent >50% of all CD8 cells, specially in old subjects or patients with chronic v
Marking IL-4-producing cells by knock-in of the IL-4 gene.: Int Immunol. 1999 Feb;11(2):243-7. Unique Identifier : AIDSLINE MED/99166952; Ho IC; Kaplan MH; Jackson-Grusby L; Glimcher LH; Grusby MJ; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, MA 02115, USA.; IL-4 is a cytokine which can be expressed by a number of cell types including Th2 cells, mast cells and a population of CD4+ NK1.1+ NK T cells. Although phenotypic markers exist for identifying each of these cell types, there is at present no known cell surface marker common to all IL-4-producing cells. Using gene tar
Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients.: Int Immunol. 1999 Feb;11(2):297-306. Unique Identifier : AIDSLINE MED/99166958; Wierenga EA; Walchner M; Kick G; Kapsenberg ML; Weiss EH; Messer G; Department of Cell Biology and Histology, Academic Medical; Center, University of Amsterdam, The Netherlands.; Allergen-specific T cells in atopic patients are polarized IL-4-producing Th2 cells, promoting IgE synthesis by B cells. The molecular basis for increased IL-4 gene expression in atopy is not fully understood. IL-4 gene regulation in general involves the nuclear factor of activated T cells (NFAT) family of transcripti
Micronutrients and the pathogenesis of human immunodeficiency virus infection.: Br J Nutr. 1999 Mar;81(3):181-9. Unique Identifier : AIDSLINE MED/99363702; Semba RD; Tang AM; Department of Ophthalmology, School of Medicine, Johns Hopkins; University, Baltimore, Maryland, USA.; rdsemba@welchlink.welch.jhu.edu; Micronutrient deficiencies may be common during human immunodeficiency virus (HIV) infection. Insufficient dietary intake, malabsorption, diarrhoea, and impaired storage and altered metabolism of micronutrients can contribute to the development of micronutrient deficiencies. Low plasma or serum levels of vitamins A, E
Structural investigation on the requirement of CCHH zinc finger type in nucleocapsid protein of human immunodeficiency virus 1.: Biochemistry. 1999 Jul 27;38(30):9600-7. Unique Identifier : AIDSLINE MED/99352180; Ramboarina S; Moreller N; Fournie-Zaluski MC; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale,; INSERM U266-CNRS UMR 8600, Paris, France.; The nucleocapsid proteins (NCps) of lentiviruses play a key role during the retroviral replication cycle. NCps contain one or two highly conserved domains characterized by a CX(2)CX(4)HX(4)C sequence which binds zinc with a high affinity. The reasons of the high conservation of zinc fingers of CCHC type in lentiviruse
3'-Azido-3'-deoxythymidine reduces the rate of transferrin receptor endocytosis in K562 cells.: Biochim Biophys Acta. 1999 Jul 8;1450(3):232-41. Unique Identifier : AIDSLINE MED/99326153; D'Alessandro AM; D'Andrea G; Di Ciccio L; Brisdelli F; Rinaldi AC; Bozzi A; Oratore A; Department of Biomedical Sciences and Technology, University of; L'Aquila, Via Vetoio Coppito, I-67100, L'Aquila, Italy.; K562 cells, exposed for at least 24 h to 5 microM 3 -azido-3 -deoxythymidine ( AZT ), gave rise to an overall increase in the number of cell surface transferrin binding receptors (18-20%). This effect was ascertained either with binding experiments by u
Self-management health education for chronic HIV infection.: AIDS Care. 1999 Feb;11(1):115-30. Unique Identifier : AIDSLINE MED/99363845; Gifford AL; Sengupta S; Department of Medicine, University of California San Diego School; of Medicine, La Jolla, USA. agifford@ucsd.edu; This paper describes the design and implementation, and presents qualitative data on the Positive Self-Management Program (PSMP), a group health education programme to help patients actively participate in their HIV/AIDS disease and symptom management. PSMP design was guided by the needs and concerns of HIV patients a
What do pregnant women think about the HIV test? A qualitative study.: AIDS Care. 1999 Feb;11(1):21-9. Unique Identifier : AIDSLINE MED/99363838; Boyd FM; Simpson WM; Hart GJ; Johnstone FD; Goldberg DJ; Department of Obstetrics and Gynaecology, University of; Edinburgh, UK. f.boyd@umds.ac.uk; Before any new antenatal screening test is introduced, the opinions of pregnant women should be considered. This is particularly relevant with HIV testing. This qualitative study reports the views of 29 women attending an antenatal clinic in a large maternity hospital in Scotland where a trial of different ways of off
A model to explain the relationship between sexual abuse and HIV risk among women.: AIDS Care. 1999 Feb;11(1):3-20. Unique Identifier : AIDSLINE MED/99363837; Miller M; Institut National de la Sante et de la Recherche Medicale-U292,; Le Kremlin-Bicetre, France. garcia.miller@wanadoo.fr; This paper presents a model developed to advance the understanding of the relationship between sexual abuse and HIV risk among women. It is proposed that the relationship is mediated by many of the long-term sequelae of sexual abuse. The process of mediation is believed to occur through various causal pathways propell
Facing the challenge: household responses to HIV/AIDS in Mumbai, India.: AIDS Care. 1999 Feb;11(1):31-44. Unique Identifier : AIDSLINE MED/99363839; Bharat S; Aggleton P; Unit for Family Studies, Tata Institute of Social Sciences,; Mumbai, India. saritaan@tiss.edu; How households and families respond to AIDS is of fundamental importance when it comes to designing programmes and interventions to provide support and care to people living with HIV disease. Where household and family responses are negative, different kinds of interventions may be needed from those where responses ar
Ethnic minorities and their vulnerability to AIDS in a border state of India.: AIDS Care. 1999 Feb;11(1):45-60. Unique Identifier : AIDSLINE MED/99363840; Thomas J; Bandyopadhyay M; HIV Social Research Project, City University of Hong Kong,; Kowloon Tong. joe.thomas@city.edu.hk; To successfully stall the spread of HIV/AIDS among the ethnic minorities in India , it is imperative that we not only understand the complexity of issues in India with regard to HIV spread among ethnic groups but also comprehend that straightforward measures that might have worked in
Do people with HIV/AIDS disclose their HIV-positivity to dentists?: AIDS Care. 1999 Feb;11(1):61-70. Unique Identifier : AIDSLINE MED/99363841; Charbonneau A; Maheux B; Beland F; Department of Oral Health, University of Montreal, Canada.; charbona@medent.umontreal.ca; This study documents behaviours of people with HIV/AIDS regarding the disclosure of their HIV-positivity when seeking dental care. An anonymous survey was conducted in Quebec, Canada , from 1993 to 1995, using a sample of 463 people with HIV/AIDS recruited from different sources. Ov
Associations of clinical parameters with health-related quality of life in hospitalized persons with HIV disease.: AIDS Care. 1999 Feb;11(1):71-86. Unique Identifier : AIDSLINE MED/99363842; Globe DR; Hays RD; Cunningham WE; Department of Pharmaceutical Economics and Policy, School of; Pharmacy, University of Southern California, Los Angeles 90033,; USA. globe@usc.edu; To assess the associations of clinical parameters with health-related quality of life (HRQOL) in hospitalized patients with HIV a cross-sectional survey and medical record review was conducted. Medical record reviews for clinical data were completed for 217 hospitalized, HIV-positive individuals. HRQOL was measured in
Prevalence of HIV infection among hospital patients in north west Tanzania.: AIDS Care. 1999 Feb;11(1):87-93. Unique Identifier : AIDSLINE MED/99363843; Kwesigabo G; Killewo JZ; Sandstrom A; Winani S; Mhalu FS; Biberfeld G; Wall S; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; gkwesigabo@muchs.ac.tz; In order to estimate hospital HIV prevalence, the economic impact of AIDS on health care and to assess the implications of HIV testing on clinical suspicion of AIDS this hospital based study was done at the government regional hospital of Kagera, Tanzania . Consecutive admissions
Foundations for effective strategies to control sexually transmitted infections: voices from rural Kenya.: AIDS Care. 1999 Feb;11(1):95-113. Unique Identifier : AIDSLINE MED/99363844; Moss W; Bentley M; Maman S; Ayuko D; Egessah O; Sweat M; Nyarang'o P; Zenilman J; Chemtai A; Halsey N; Department of International Health, School of Hygiene and Public; Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.; wmoss@welchlink.welch.jhu.edu; Achieving maximal benefit from clinic-based, sexually transmitted infection (STI) control strategies requires that persons seek treatment at public clinics. Community-based, ethnographic research methods were used to examine patterns of health-seeking behavior for sexually transmitted infections in western
[HIV infection in aged patients (editorial)]: An Med Interna. 1999 Jun;16(6):271-2. Unique Identifier : AIDSLINE MED/99351193; Rodriguez Pascual C
[In old age ... AIDS. Is it worth to initiate antiretroviral treatment? Review of 37 patients more than 60 years of age]: An Med Interna. 1999 Jun;16(6):273-6. Unique Identifier : AIDSLINE MED/99351194; de Gorgolas M; Bello E; Garcia Vazquez E; Moya MJ; Garcia Delgado R; Fernandez Guerrero ML; Division de Enfermedades Infecciosas, Fundacion Jimenez Diaz,; Universidad Autonoma, Madrid.; INTRODUCTION: HIV infection is common in young persons and its clinical picture, outcome and response to antiretroviral therapy is well known, but it is not the case in the elderly. OBJECTIVES: To evaluate the clinical characteristics and response to antiretroviral therapy of HIV elderly patients. DESIGN: Retrospectiv
[Epidemiology of tuberculosis in Galicia]: An Med Interna. 1999 Jun;16(6):290-6. Unique Identifier : AIDSLINE MED/99351198; Anibarro Garcia L; Vazquez-Gallardo R; Toubes Navarro ME; Penas Truque A; Lema Mougan R; Tunez Bastida V; Vazquez Serrano E; Fernandez Nogueira E; Unidade de Tuberculose de Galicia, Direccion Xeral de Saude; Publica, Xunta de Galicia, Santiago de Compostela.; BACKGROUND: To know the real incidence of tuberculosis in Galicia and its epidemiological characteristics. METHODS: Study of data recorded in the Galician Programme for Tuberculosis Control and Prevention , where an active epidemiological survey of every diagnosis of tuberculosis is carried out in every part of Galic
Antiviral therapy for hepatitis B and C in Asians.: J Gastroenterol Hepatol. 1999 May;14 Suppl:S19-21. Unique Identifier : AIDSLINE MED/99310006; Lai CL; Department of Medicine, The University of Hong Kong, Queen Mary; Hospital, Hong Kong. hrmelcl@hkucc.hku.hk; The clinical features and treatment of chronic hepatitis C in Chinese patients are the same as in Caucasian patients except that 27% of Chinese chronic hepatitis C patients have hepatitis C virus (HCV) genotype 6a. In contrast, Chinese patients with chronic hepatitis B (CHB) differ from Caucasian patients because the
Does Asian race affect hepatitis B virus recurrence or survival following liver transplantation for hepatitis B cirrhosis?: J Gastroenterol Hepatol. 1999 May;14 Suppl:S48-52. Unique Identifier : AIDSLINE MED/99310012; So SK; Esquivel CO; Imperial JC; Garcia G; Monge H; Keeffe EB; Department of Surgery and Medicine, Stanford Asia Liver Center,; Stanford University School of Medicine, California, USA.; samso@stanford.edu; To assess whether Asian race is an independent variable affecting survival and hepatitis B virus (HBV) recurrence after liver transplantation, the results of 27 consecutive liver transplants performed between June 1994 and April 1997 for HBV cirrhosis were analysed. In the group of 13 Asians, 38% had associated hepato
Update on clinical trials in the treatment of hepatitis B.: J Gastroenterol Hepatol. 1999 May;14 Suppl:S6-11. Unique Identifier : AIDSLINE MED/99310004; Pessoa MG; Wright TL; Department of Veterans Affairs Medical Center, University of; California, San Francisco 94121, USA.; Chronic hepatitis B infection is a worldwide public health problem, which is particularly important in countries of Asia. Interferon has long been available for the treatment of patients with active replication (hepatitis B virus (HBV) e antigen and HBV-DNA positive) with evidence of chronic liver disease (elevated se
Relationships between work and HIV/AIDS status.: Occup Med (Lond). 1999 Feb;49(2):115-6. Unique Identifier : AIDSLINE MED/99365617; Vitry-Henry L; Penalba C; Beguinot I; Deschamps F; Department of Occupational Diseases, Hopital Maison Blanche,; Reims, France.; The aim of this study was to assess reasons contributing to a cessation of occupational activities in HIV-infected persons. One hundred patients were studied, 55 of whom were working at the time of the study while 45 were unemployed. Twenty of the patients had been diagnosed as having AIDS and the remaining patients w
The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals.: Blood. 1999 Aug 1;94(3):1003-11. Unique Identifier : AIDSLINE MED/99350147; Marshall JD; Chehimi J; Gri G; Kostman JR; Montaner LJ; Trinchieri G; Wistar Institute of Anatomy and Biology, Division of Immunologic; and Infectious Diseases of the Children's Hospital of; Philadelphia, PA 19104, USA.; Interleukin-12 (IL-12) is a potentially critical factor in the immune response against human immunodeficiency virus (HIV) because it is important for regulating proliferation and interferon-gamma (IFN-gamma) production by T cells and natural killer (NK) cells, antigen presentation and accessory cell function by macrop
Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo.: Blood. 1999 Aug 1;94(3):1021-7. Unique Identifier : AIDSLINE MED/99350149; Sloand EM; Kumar PN; Kim S; Chaudhuri A; Weichold FF; Young NS; National Heart, Lung and Blood Institute, National Institutes of; Health, Bethesda, MD, USA.; CD4(+) T cells from patients with human immunodeficiency virus (HIV) infection undergo apoptosis at an increased rate, which leads to their depletion during disease progression. Both the Fas-Receptor (Fas-R) and interleukin-1beta (IL-1beta)-converting enzyme (ICE; caspase 1) appear to play a role in the mechanism of a
Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses.: Unique Identifier : AIDSLINE MED/99350135; Rook AH; Wood GS; Yoo EK; Elenitsas R; Kao DM; Sherman ML; Witmer WK; Rockwell KA; Shane RB; Lessin SR; Vonderheid EC; Progression of cutaneous T-cell lymphoma (CTCL) is associated with profound defects in cell-mediated immunity and depressed production of cytokines, which support cell-mediated immunity. Because we have observed marked defects in interleukin-12 (IL-12) production in CTCL and because IL-12 is critical for antitumor cyt
T-cell receptor-independent activation of clonal Th2 cells associated with chronic hypereosinophilia.: Blood. 1999 Aug 1;94(3):994-1002. Unique Identifier : AIDSLINE MED/99350146; Roufosse F; Schandene L; Sibille C; Kennes B; Efira A; Cogan E; Goldman M; Departments of Immunology and Internal Medicine, Hopital Erasme,; Universite Libre de Bruxelles, Brussels, Belgium.; We recently observed a clonal expansion of CD3(-)CD4(+) T cells secreting Th2-type cytokines in patients presenting chronic hypereosinophilia. As clonal T cells isolated from such patients did not spontaneously secrete cytokines in vitro, we reasoned that costimulatory signals delivered by antigen-presenting cells mig
Successful treatment of a pseudoaneurysm of the cystic artery with microcoil embolization.: J Vasc Interv Radiol. 1999 Jun;10(6):789-92. Unique Identifier : AIDSLINE MED/99320120; Delgadillo X; Berney T; de Perrot M; Didier D; Morel P; Clinic of Digestive Surgery, Geneva University Hospital,; Switzerland.; Pseudoaneurysms of visceral arteries are uncommon but well-characterized vascular abnormalities, usually provoked by intraabdominal inflammatory processes such as pancreatitis or cholecystitis, or by surgical trauma. However, pseudoaneurysms of the cystic artery are rare. They complicate cholecystitis or cholecystecto
Production of chemokines CTAPIII and NAP/2 by digestion of recombinant ubiquitin-CTAPIII with yeast ubiquitin C-terminal hydrolase and human immunodeficiency virus protease.: Protein Expr Purif. 1999 Jul;16(2):347-54. Unique Identifier : AIDSLINE MED/99350754; Mildner AM; Paddock DJ; LeCureux LW; Leone JW; Anderson DC; Tomasselli AG; Heinrikson RL; Protein Science, Cell and Molecular Biology, Pharmacia and; Upjohn, 301 Henrietta Street, Kalamazoo, Michigan 49007, USA.; Recombinant yeast ubiquitin C-terminal hydrolase (YUH1), which has an N-terminal (His)(6) tag, and an autolysis-resistant mutant of the human immunodeficiency virus-1 protease (HIV-1 Pr) have been used as specific proteases to yield peptides from a ubiquitin conjugate. In the present example, connective tissue-activat
High-level expression and purification of biologically active recombinant pokeweed antiviral protein.: Unique Identifier : AIDSLINE MED/99350756; Rajamohan F; Engstrom CR; Denton TJ; Engen LA; Kourinov I; Uckun FM; Pokeweed antiviral protein (PAP) from the leaves of the pokeweed plant, Phytolacca americana, is a naturally occurring single-chain ribosome-inactivating protein, which catalytically inactivates both prokaryotic and eukaryotic ribosomes. The therapeutic potential of PAP has gained considerable interest in recent years
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 Jun 25;9(26):235-6. Unique Identifier : AIDSLINE MED/99354545
Detection of new Enterocytozoon genotypes in faecal samples of farm dogs and a cat.: Parasite. 1999 Jun;6(2):189-93. Unique Identifier : AIDSLINE GENBANK/AF119100; Mathis A; Breitenmoser AC; Deplazes P; Institute of Parasitology, University of Zurich, Switzerland.; maal@vetparas.unizh.ch; The microsporidian species Enterocytozoon bieneusi had emerged as opportunistic pathogen in AIDS patients causing chronic diarrhoea and was found with high prevalences in faeces of asymptomatic pigs. Analysis of the ribosomal RNA gene internal transcribed spacer (rDNA ITS) had revealed that nine distinct but closely r
[Results and epidemiological impact of directly observed treatment of tuberculosis]: Arch Bronconeumol. 1999 Jun;35(6):267-74. Unique Identifier : AIDSLINE MED/99338395; Alcaide Megias J; Pascual Torramade J; Altet Gomez MN; Maldonado Diaz de Losada J; Lopez Espinosa F; Salleras Sanmarti L; Centro de Prevencion y Control de la Tuberculosis Dr. Lluis; Saye. jalcaide@dsss.scs.es; OBJECTIVES: To analyze the results and epidemiological impact on tuberculosis (TB) of directly observed therapy (DOT) for uncooperative patients. METHOD: Retrospective study of the case histories of patients admitted to the DOT unit in Catalonia ( Spain ) since its March 1993 inaugura
T cell numbers relate to bone involvement in Gaucher disease.: Blood Cells Mol Dis. 1999 Apr;25(2):130-8. Unique Identifier : AIDSLINE MED/99317826; Lacerda L; Arosa FA; Lacerda R; Cabeda J; Porto G; Amaral O; Fortuna A; Pinto R; Oliveira P; McLaren CE; Sa Miranda C; de Sousa M; Department of Genetics Neurobiology, Porto University, Portugal.; The major elements of bone pathology in Gaucher disease are a failure of osteoclast and osteoblast function, resulting in osteopenia and also osteonecrosis. T lymphocytes have recently been found to be involved in the regulation of osteoblast/osteoclast activity in vitro. In the present report the peripheral blood T m
Overview of HIV infection.: Ann Allergy Asthma Immunol. 1999 Jul;83(1):1-5; quiz 6-7. Unique Identifier : AIDSLINE MED/99364519; Temesgen Z; Division of Infectious Diseases, Mayo Clinic, Rochester,; Minnesota, USA.; LEARNING OBJECTIVE: To understand the current status of infection with the human immunodeficiency virus (HIV), including epidemiology, treatment, and recent advances. DATA SOURCES: Relevant articles and publications from the medical literature, including the Joint United Nations Programme on HIV/AIDS (
Activity and safety of DNA plasmids encoding IL-4 and IFN gamma.: Gene Ther. 1999 Feb;6(2):237-44. Unique Identifier : AIDSLINE MED/99363966; Ishii KJ; Weiss WR; Ichino M; Verthelyi D; Klinman DM; Retroviral Immunology Section, Food and Drug Administration,; Bethesda, MD 20892, USA.; Cytokine-encoding DNA plasmids can act as genetic adjuvants , improving the immune response stimulated by co-administered DNA vaccines. We examined whether plasmids encoding the Th1 cytokine IFN gamma (pIFN gamma) or the Th2 cytokine IL-4 (pIL-4) have long-term effects on immune homeostasis when administered to adult
Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial.: Gene Ther. 1999 Mar;6(3):350-63. Unique Identifier : AIDSLINE MED/99363943; Stewart AK; Lassam NJ; Quirt IC; Bailey DJ; Rotstein LE; Krajden M; Dessureault S; Gallinger S; Cappe D; Wan Y; Addison CL; Moen RC; Gauldie J; Graham FL; Toronto Hospital, Ontario, Canada.; We conducted a phase 1 trial of direct injection of an E1, E3-deleted adenovirus encoding interleukin-2 (AdCAIL-2) into subcutaneous deposits of melanoma or breast cancer. Twenty-three patients were injected at seven dose levels (10(7)-10(10) p.f.u). Local inflammation was observed at the site of injection in 60% of p
Artificial capillary culture: expansion and retroviral transduction of CD4+ T-lymphocytes for clinical application.: Gene Ther. 1999 Mar;6(3):373-84. Unique Identifier : AIDSLINE MED/99363945; Knop AE; Arndt AJ; Raponi M; Boyd MP; Ely JA; Symonds G; Johnson & Johnson Research Laboratories, New South Wales,; Australia.; An artificial capillary culture/transduction technique has been developed for application in a phase I gene therapy clinical trial for HIV. The trial protocol involves isolation of CD4+ T-lymphocytes from a genetically matched HIV negative twin, retroviral transduction of equal numbers of cells with the ribozyme thera
Impact of chimeric immune receptor extracellular protein domains on T cell function.: Gene Ther. 1999 Mar;6(3):412-9. Unique Identifier : AIDSLINE MED/99363949; Patel SD; Moskalenko M; Smith D; Maske B; Finer MH; McArthur JG; Cell Genesys Inc., Department of Preclinical Biology and; Immunology, Foster City, CA 94404, USA.; Chimeric immune receptors (CIR) encompass tumor- or virus-specific ligands or antibodies fused to the signaling domains of either the T cell receptor or Fc receptor. T cells expressing these receptors recapitulate the cytopathic effects mediated by the T cell receptor and allow the targeting of tumor or virus infected
Characterisation of immunological reactivity of patients with adverse effects during therapy with an aqueous mistletoe extract.: Eur J Med Res. 1999 May 26;4(5):169-77. Unique Identifier : AIDSLINE MED/99269316; Stein GM; Berg PA; Krebsforschung Herdecke, Dept. of Applied Immunology, Communal; Hospital, University Witten/Herdecke, Gerhard-Kienle Weg 4,; D-58313 Herdecke, Germany. stein.g@primus-online.de; Drugs, which are effective are also bond to exert adverse effects. This is also true for mistletoe extracts. Extracts from European mistletoe (Viscum album, VAL) belong to the complementary therapeutic regimens and are used for adjuvant cancer therapy. This study was performed to characterise immunological reactivity
7th German AIDS Conference. Essen, 2-6 June 1999. Abstracts.: Eur J Med Res. 1999 Jun 2;4 Suppl 1:1-74. Unique Identifier : AIDSLINE MED/99378989
Fas modulates both positive and negative selection of thymocytes.: Cell Immunol. 1999 Jun 15;194(2):127-35. Unique Identifier : AIDSLINE MED/99315455; Kurasawa K; Hashimoto Y; Iwamoto I; Department of Internal Medicine II, Chiba University School of; Medicine, Chiba, 260, Japan.; We studied the functional role of Fas (CD95) in thymic T cell development using the TCR transgenic mice homozygous for the lpr mutation, DO10 lpr/lpr mice. In DO10 lpr/lpr mice, the differentiation of CD4(+)CD8(+) double-positive (DP) thymocytes to CD4(+) single-positive (SP) thymocytes was markedly impaired, as indic
Communicable Diseases Surveillance.: Commun Dis Intell. 1999 May 13;23(5):132-9. Unique Identifier : AIDSLINE MED/99357946
Communicable diseases surveillance. you left an error in the record.: Commun Dis Intell. 1999 Jun 10;23(6):173-81. Unique Identifier : AIDSLINE MED/99361328
New expanded guidelines for preventing HIV [news]: CMAJ. 1999 Jul 27;161(2):122. Unique Identifier : AIDSLINE MED/99368685
The changing face of AIDS in Canada [news]: CMAJ. 1999 Jul 27;161(2):124. Unique Identifier : AIDSLINE MED/99368686; Buske L
Blood money [letter]: CMAJ. 1999 Jul 27;161(2):129. Unique Identifier : AIDSLINE MED/99368692; Massel D
New-onset diabetes mellitus associated with protease inhibitor therapy in an HIV-positive patient: case report and review.: CMAJ. 1999 Jul 27;161(2):161-4. Unique Identifier : AIDSLINE MED/99368699; Lee EC; Walmsley S; Fantus IG; Department of Medicine, Mount Sinai Hospital, Toronto, Ont.
New ethical obligations accompany new HIV drugs, conference told.: CMAJ. 1999 Jul 27;161(2):187. Unique Identifier : AIDSLINE MED/99368703; Silversides A
Cardiac complications in children with human immunodeficiency virus infection. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group, National Heart, Lung, and Blood Institute.: Pediatrics. 1999 Aug;104(2):e14. Unique Identifier : AIDSLINE MED/99359806; Starc TJ; Lipshultz SE; Kaplan S; Easley KA; Bricker JT; Colan SD; Lai WW; Gersony WM; Sopko G; Moodie DS; Schluchter MD; Department of Pediatrics, Division of Pediatric Cardiology,; Presbyterian Hospital/Columbia University School of Medicine, New; York, New York 10032, USA. tjs1@columbia.edu; OBJECTIVE: Although numerous cardiac abnormalities have been reported in HIV-infected children, precise estimates of the incidence of cardiac disease in these children are not well-known. The objective of this report is to describe the 2-year cumulative incidence of cardiac abnormalities in HIV-infected children. METH
Plant sterols and sterolins: a review of their immune-modulating properties.: Altern Med Rev. 1999 Jun;4(3):170-7. Unique Identifier : AIDSLINE MED/99316132; Bouic PJ; Lamprecht JH; Department of Medical Microbiology, Medical Faculty, University; of Stellenbosch. Tygerberg 7505, South Africa.; pjdb@gerga.sun.ac.za; Beta-sitosterol (BSS) and its glycoside (BSSG) are sterol molecules which are synthesized by plants. When humans eat plant foods phytosterols are ingested, and are found in the serum and tissues of healthy individuals, but at concentrations orders of magnitude lower than endogenous cholesterol. Epidemiological studies
Detection and treatment of twinning: an improvement and new results.: Acta Crystallogr D Biol Crystallogr. 1999 Jun;55 ( Pt 6):1179-87. Unique Identifier : AIDSLINE MED/99263331; Dumas P; Ennifar E; Walter P; Institut de Biologie Moleculaire et Cellulaire du CNRS, UPR9002,; 15 rue Rene Descartes, F67084 Strasbourg CEDEX, France.; dumas@ibmc.u-strasbg.fr; This work deals with two aspects of the twinning problem. Firstly, an improvement of a known statistical test aimed at detecting twinning is presented and, secondly, a new parametrization of twinning is described, as well as a new method to obtain an accurate estimate of the degree of twinning. During work on crystals
Developmental factors of urethral human papillomavirus lesions: correlation with circumcision.: BJU Int. 1999 Jul;84(1):57-60. Unique Identifier : AIDSLINE MED/99373700; Aynaud O; Piron D; Bijaoui G; Casanova JM; College Europeen et Francophone d'Urologie Liberale, Paris,; France.; OBJECTIVE: To assess the relationship between circumcision and urethral human papillomavirus (HPV) lesions, and the influence of urethritis on the development of urethral HPV infections on inducing squamous metaplasia of the urethral epithelium. PATIENTS AND METHODS: The study included 210 heterosexual, HIV-negative m
Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration.: Clin Exp Immunol. 1999 Aug;117(2):291-7. Unique Identifier : AIDSLINE MED/99373631; Krampera M; Vinante F; Tavecchia L; Morosato L; Chilosi M; Romagnani S; Zanolin ME; Pizzolo G; Department of Haematology, University of Verona, Italy.; In order to investigate the T cell cytokine profile during age-dependent maturation of the immune response, we evaluated the cytokine expression of CD4+ and CD8+ circulating cells by flow cytometric single-cell analysis after non-specific stimulation in vitro in different age groups of normal individuals, from cord bl
Transcriptional activation of HIV by Mycobacterium tuberculosis in human monocytes.: Clin Exp Immunol. 1999 Aug;117(2):324-30. Unique Identifier : AIDSLINE MED/99373636; Toossi Z; Xia L; Wu M; Salvekar A; Case Western Reserve University, Cleveland, OH 44106-4984, USA.; Recently it has been shown that infection with Mycobacterium tuberculosis increases the replication of HIV in mononuclear cells. The objective of this study was to investigate the mechanism(s) of up-regulation of HIV in primary human monocytes. Monocytes from healthy subjects were infected with HIV in vitro and then c
Alterations in blood leucocyte adhesion molecule profiles in HIV-1 infection.: Clin Exp Immunol. 1999 Aug;117(2):331-4. Unique Identifier : AIDSLINE MED/99373638; Hayes PJ; Miao YM; Gotch FM; Gazzard BG; Department of Immunology, Imperial College School of Medicine,; London, UK.; CD4 and CD8 lymphocyte numbers in the gut lamina propria are grossly altered in HIV-1 infection, out of proportion to alterations in the circulation. Such alterations in lymphocyte counts in the tissues may be due to altered leucocyte migration from the blood. One factor affecting leucocyte migration is adhesion molec
Decreased CD40 ligand induction in CD4 T cells and dysregulated IL-12 production during HIV infection.: Clin Exp Immunol. 1999 Aug;117(2):335-42. Unique Identifier : AIDSLINE MED/99373637; Vanham G; Penne L; Devalck J; Kestens L; Colebunders R; Bosmans E; Thielemans K; Ceuppens JL; Laboratory of Immunology, Department of Microbiology, Institut of; Tropical Medicine, Antwerpen, Belgium. gvanham@itg.be; During HIV infection various cytokines are overproduced in early stages, whereas in advanced disease cytokines of the T helper 1 type (e.g. interferon-gamma (IFN-gamma)) are selectively deficient. During antigenic stimulation, the production of type-1 cytokines is enhanced by IL-12, secreted by antigen-presenting cell
Blood-borne virus infections in dialysis units--a review.: Rev Med Virol. 1999 Apr-Jun;9(2):101-9. Unique Identifier : AIDSLINE MED/99314115; Wreghitt TG; Clinical Microbiology and Public Health Laboratory, Addenbrooke's; Hospital, Cambridge, UK.; Hepatitis outbreaks in haemodialysis unit patients and staff were reported in the late 1960s. In 1972, the Rosenheim report in the UK established guidelines which included routine tests for hepatitis B surface antigen and isolation facilities for dialysing patients with hepatitis B virus which resulted in a dramatic f
The Nef protein of primate lentiviruses.: Rev Med Virol. 1999 Apr-Jun;9(2):111-20. Unique Identifier : AIDSLINE MED/99314116; Piguet V; Trono D; Department of Genetics and Microbiology, Centre Medical; Universitaire, Geneva, Switzerland.; The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may accelerate HIV progression and disease in humans. Additionally, a Nef-de
Role of beta-chemokines in HIV-1 infection of dendritic cells maturing from CD34+ stem cells.: Unique Identifier : AIDSLINE MED/99347608; Wang H; English NJ; Reid CD; Merson JE; Knight SC; Antigen Presentation Research Group, Imperial College School of; Medicine, Northwick Park Institute for Medical Research, Harrow,; UK.; OBJECTIVES: To study the susceptibility to infection by different strains of HIV-1 viruses and the roles of chemokines (macrophage inflammatory protein-1alpha [MIP-1alpha], MIP-1beta, and regulated-on-activation-T-expressed-and-secreted [RANTES]) in CD34+ stem cells maturing into dendritic cells (DC). DESIGN: It has b
CCR5 genotype and resistance to vertical transmission of HIV-1.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):189-93. Unique Identifier : AIDSLINE MED/99347609; Philpott S; Burger H; Charbonneau T; Grimson R; Vermund SH; Visosky A; Nachman S; Kovacs A; Tropper P; Frey H; Weiser B; Wadsworth Center, New York State Department of Health, Albany; 12208-2022, USA.; A human gene has been identified that affects susceptibility to HIV-1 infection. The gene codes for CCR5, the coreceptor for macrophage-tropic strains of HIV-1. Individuals who are homozygous for a deleted, mutant form of the gene, delta32, display a high degree of natural resistance to sexual and parenteral transmiss
Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):194-202. Unique Identifier : AIDSLINE MED/99347610; Al-Harthi L; Roebuck KA; Olinger GG; Landay A; Sha BE; Hashemi FB; Spear GT; Department of Immunology/Microbiology, Rush-Presbyterian-St.; Luke's Medical Center, Chicago, Illinois 60612, USA.; lalharth@rush.edu; Alteration of cervicovaginal microbial flora can lead to vaginosis, which is associated with an increased risk of HIV-1 transmission. We recently characterized a soluble HIV-inducing factor (HIF) from the cervicovaginal lavage (CVL) samples of women. The goals of this study were to determine the effect of cervicovagin
Development and significance of the HIV-1 reverse transcriptase M184V mutation during combination therapy with lamivudine, zidovudine, and protease inhibitors.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):203-8. Unique Identifier : AIDSLINE MED/99347611; Catucci M; Venturi G; Romano L; Riccio ML; De Milito A; Valensin PE; Zazzi M; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; To analyze the emergence and role of the lamivudine ( 3TC )-selected HIV-1 reverse transcriptase (RT) M184V mutation under triple therapy, we performed a retrospective study of 40 nucleoside RT inhibitor-pretreated and 16 drug-naive patients who were sw
Insulin resistance in HIV protease inhibitor-associated diabetes.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):209-16. Unique Identifier : AIDSLINE MED/99347612; Yarasheski KE; Tebas P; Sigmund C; Dagogo-Jack S; Bohrer A; Turk J; Halban PA; Cryer PE; Powderly WG; Division of Endocrinology, Diabetes, and Metabolism, Washington; University Medical School, St. Louis, Missouri 63110, USA.; key@imgate.wustl.edu; BACKGROUND: Fasting hyperglycemia has been associated with HIV protease inhibitor (PI) therapy. OBJECTIVE: To determine whether absolute insulin deficiency or insulin resistance with relative insulin deficiency and an elevated body mass index (BMI) contribute to HIV PI-associated diabetes. DESIGN: Cross-sectional eval
Prevention of mother-to-child transmission of HIV in Thailand: physicians' attitudes on zidovudine use, pregnancy termination, and willingness to provide care.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):217-22. Unique Identifier : AIDSLINE MED/99347613; Stringer JS; Stringer EM; Phanuphak P; Jetwana P; Reinprayoon D; Funkhouser EM; Vermund SH; Department of Obstetrics and Gynecology, University of Alabama at; Birmingham, 35294-2170, USA. uabobgyn@aol.com; We administered a survey to Thai physicians, using regular mail, on their attitudes and practices regarding zidovudine (ZDV) use and pregnancy termination in HIV-infected pregnant women. We surveyed their willingness to care for these patients as well. In 1997, 79.5% of 480 respondents reported that they did not routi
Adequacy of prenatal care and prescription of zidovudine to prevent perinatal HIV transmission.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):223-7. Unique Identifier : AIDSLINE MED/99347614; Lansky A; Jones JL; Burkham S; Reynolds K; Bohannon B; Bertolli J; U.S. Centers for Disease Control and Prevention, National Center; for HIV, STD, and TB Prevention, Division of HIV/AIDS; Prevention-Surveillance and Epidemiology, Atlanta, Georgia 30333,; USA. all0@cdc.gov; In 1994, data were published on the effectiveness of zidovudine in preventing perinatal transmission of HIV infection. Using data from surveillance projects in San Antonio, Dallas, and Houston, Texas, U.S.A., we linked records of children born from 1987 through 1996 with records of their HIV-infected mothers. Prenatal
Adherence to guidelines for antiretroviral therapy and for preventing opportunistic infections in HIV-infected adults and adolescents in Ryan White-funded facilities in the United States.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):228-35. Unique Identifier : AIDSLINE MED/99347615; Kaplan JE; Parham DL; Soto-Torres L; van Dyck K; Greaves JA; Rauch K; Ellis B; Amandus HE; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, Sexually Transmitted Diseases, and; Tuberculosis Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA. jxk2@cdc.gov; To determine adherence by health care providers to guidelines for antiretroviral therapy and for prevention of opportunistic infections (OIs) in adults with HIV infection in federally funded facilities in the United States , we reviewed records of HIV-infected adults (>13 years) in 11 R
Effect of receptive oral sex and smoking on the incidence of hairy leukoplakia in HIV-positive gay men.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):236-42. Unique Identifier : AIDSLINE MED/99347616; Shiboski CH; Neuhaus JM; Greenspan D; Greenspan JS; Oral AIDS Center, Department of Stomatology, University of; California, San Francisco, 94143-0422, USA. caro@nanook.ucsf.edu; We sought to determine whether hairy leukoplakia (HL), an Epstein-Barr virus-related oral lesion, is associated with receptive oral sex activity and cigarette smoking among HIV-positive gay men. Oral examinations were conducted every 6 months among San Francisco Men s Health Study participants over a 6-year period. We
Willingness of injection drug users to participate in an HIV vaccine efficacy trial in Bangkok, Thailand.: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):243-51. Unique Identifier : AIDSLINE MED/99347617; MacQueen KM; Vanichseni S; Kitayaporn D; Lin LS; Buavirat A; Naiwatanakul T; Raktham S; Mock P; Heyward WL; Des Jarlais DC; Choopanya K; Mastro TD; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA. kmm3@cdc.gov; We assessed willingness to participate in an HIV recombinant gp120 bivalent subtypes B/E candidate vaccine efficacy trial among 193 injection drug users (IDUs) attending drug treatment clinics in Bangkok, Thailand . IDUs previously enrolled in a prospective cohort study were invit
Supplemental vitamin B and progression to AIDS and death in black South African patients infected with HIV [letter]: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):252-3. Unique Identifier : AIDSLINE MED/99347618; Kanter AS; Spencer DC; Steinberg MH; Soltysik R; Yarnold PR; Graham NM
Decreased peripheral circulation of HIV-infected cells in a subset of long-term nonprogressors. The French ALT Study Group [letter]: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):253-5. Unique Identifier : AIDSLINE MED/99347619; Candotti D; Calvez V; Autran B; Costagliola D; Rouzioux C; Agut H
Evidence for a local synthesis of beta-chemokines within the genital tract of both HIV-1-infected and uninfected women [letter]: J Acquir Immune Defic Syndr. 1999 Jul 1;21(3):255-7. Unique Identifier : AIDSLINE MED/99347620; Fiore JR; Di Stefano M; Lepera A; Saracino A; Monno L; Angarano G; Pastore G
Bacteremic pneumococcal pneumonia in HIV-seropositive and HIV-seronegative adults.: Chest. 1999 Jul;116(1):107-14. Unique Identifier : AIDSLINE MED/99351798; Feldman C; Glatthaar M; Morar R; Mahomed AG; Kaka S; Cassel M; Klugman KP; Department of Medicine, Hillbrow Hospital, University of the; Witwatersrand, Johannesburg, South Africa.; 014charl@chiron.wits.ac.za; STUDY OBJECTIVES: To compare the demographic, clinical, laboratory, and microbiological data, and the hospital course and outcome of HIV-seropositive and HIV-seronegative adults with bacteremic pneumococcal pneumonia. DESIGN: Retrospective observation study conducted over a 2-year period. SETTING: Academic teaching ho
Downward trends in bronchoscopies performed between 1991 and 1997.: Chest. 1999 Jul;116(1):238-42. Unique Identifier : AIDSLINE MED/99351818; Balfe D; Mohsenifar Z; Department of Medicine, Cedars-Sinai Medical Center, UCLA School; of Medicine, Los Angeles, CA 90048, USA.; STUDY OBJECTIVE: To examine the frequency of bronchoscopy performance in a large tertiary medical center over a period of 8 years. DESIGN: Retrospective data analysis. SETTING: Academic medical center. MATERIALS AND METHODS: Using a computerized database of all bronchoscopies performed between 1991 and 1997, we analyz
Diagnostic value of pleural fluid adenosine deaminase in tuberculous pleuritis with reference to HIV coinfection and a Bayesian analysis [see comments]: Unique Identifier : AIDSLINE MED/99351796; Riantawan P; Chaowalit P; Wongsangiem M; Rojanaraweewong P; OBJECTIVES: To evaluate the diagnostic use of pleural fluid adenosine deaminase (ADAPF) levels in tuberculous pleuritis (TBpl), with a special reference to HIV coinfection and a
Alloreactive Th1 cells localize in lung and induce acute lung injury.: Chest. 1999 Jul;116(1 Suppl):36S-37S. Unique Identifier : AIDSLINE MED/99351871; Dixon AE; Mandac JB; Martin PJ; Madtes DK; Hackman RC; Clark JG; Fred Hutchinson Cancer Research Center and University of; Washington, Seattle 98109-1024, USA.
Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IkappaBalpha turnover.: Eur J Biochem. 1999 Jul;263(1):202-11. Unique Identifier : AIDSLINE MED/99359388; Crinelli R; Bianchi M; Gentilini L; Magnani M; Hiscott J; Instuto di Chimica Biologica 'G. Fornaini', University of Urbino,; Italy.; Murine acquired immunodeficiency syndrome (MAIDS) is a complex immunopathology caused by a defective murine leukemia virus (LP-BM5) that mainly targets B-lymphocytes. Lymphadenophathy, splenomegaly, hypergammaglobulinemia and progressive immunodeficiency are prominent features of MAIDS. Previously, we showed that the
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.: Eur J Biochem. 1999 Jul;263(1):238-45. Unique Identifier : AIDSLINE MED/99359392; Mahalingam B; Louis JM; Reed CC; Adomat JM; Krouse J; Wang YF; Harrison RW; Weber IT; Department of Microbiology and Immunology, Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, USA.; Mutants of HIV-1 protease that are commonly selected on exposure to different drugs, V82S, G48V, N88D and L90M, showed reduced catalytic activity compared to the wild-type protease on cleavage site peptides, CA-p2, p6pol-PR and PR-RT, critical for viral maturation. Mutant V82S is the least active (2-20% of wild-type p
High affinity interaction of HIV-1 integrase with specific and non-specific single-stranded short oligonucleotides.: FEBS Lett. 1999 Jul 16;455(1-2):154-8. Unique Identifier : AIDSLINE MED/99355445; Caumont A; Jamieson G; de Soultrait VR; Parissi V; Fournier M; Zakharova OD; Bayandin R; Litvak S; Tarrago-Litvak L; Nevinsky GA; EP 630 CNRS-Universite Victor Segalen Bordeaux 2, France.; Retroviral integrase (IN) catalyzes the integration of double-stranded viral DNA into the host cell genome. The reaction can be divided in two steps: 3 -end processing and DNA strand transfer. Here we studied the effect of short oligonucleotides (ODNs) on human immunodeficiency virus type 1 (HIV-1) IN. ODNs were eithe
Biochemical diversity of Mycoplasma fermentans strains.: FEMS Microbiol Lett. 1999 Jul 1;176(1):177-81. Unique Identifier : AIDSLINE MED/99346698; Ozcan SA; Miles R; Division of Life Sciences, King's College, London, UK.; fthl@yahoo.com; In this study, the metabolism of a diverse range of Mycoplasma fermentans strains was investigated. It was shown that the ability to utilise glucose, fructose and N-acetylglucosamine differentiated strains, and that the patterns and kinetics of substrate utilisation were correlated with the site of isolation, i.e. joi
The origin and evolution of human T-cell lymphotropic virus type II (HTLV-II) and the relationship with its replication strategy.: Gene. 1999 Jun 24;234(1):11-21. Unique Identifier : AIDSLINE MED/99321794; Salemi M; Vandamme AM; Desmyter J; Casoli C; Bertazzoni U; Rega Institute for Medical Research, KULeuven, B-3000, Leuven,; Belgium. marco.salemi@uz.kuleuven.ac.be; In this review, the origin and evolution of the human T-cell lymphotropic virus type II (HTLV-II) are discussed, with particular emphasis on its high genomic stability. In particular, it appears that the virus originated in the African continent and has been infecting human populations for several thousands of years.
Homeless patients with hepatocellular carcinoma in Osaka City, Japan.: Hepatogastroenterology. 1999 Mar-Apr;46(26):1106-10. Unique Identifier : AIDSLINE MED/99298813; Sakai Y; Seki S; Nishiguchi S; Kuroki T; Kitada T; Enomoto M; Satake K; Monna T; Department of Public Health, Osaka City University Medical; School, Japan.; BACKGROUND/AIMS: Although the number of homeless persons is increasing worldwide, studies delineating the health status of these persons according to various medical perspectives, including hepatology, are limited. However, such studies are important for understanding the pathogenesis of diseases and their prevention.
Initial daily interferon administration can gain more eradication of HCV-RNA in patients with chronic hepatitis C, especially with serum intermediate viral load.: Hepatogastroenterology. 1999 Mar-Apr;46(26):1131-9. Unique Identifier : AIDSLINE MED/99298818; Nakamura H; Ito H; Ogawa H; Takeda A; Kanazawa S; Kuroda T; Yamamoto M; Enomoto H; Kimura Y; Zenda S; Terabayashi M; Saeki K; Noguchi S; Hara H; Uemiya M; Igarashi A; Hayashi E; Department of Medicine III, Osaka University Medical School,; Japan.; BACKGROUND/AIMS: We studied the effect of initial daily administration of interferon for the treatment of chronic hepatitis C, especially in patients with intermediate viral load. METHODOLOGY: Consecutive patients who met the inclusion criteria were randomly enrolled into two groups in this study. All patients analyze
Induction of effective antitumor immunity in a mouse brain tumor model using B7-1 (CD80) and intercellular adhesive molecule 1 (ICAM-1; CD54) transfection and recombinant interleukin 12.: Int J Cancer. 1999 Aug 27;82(5):714-20. Unique Identifier : AIDSLINE MED/99352371; Joki T; Kikuchi T; Akasaki Y; Saitoh S; Abe T; Ohno T; Department of Neurosurgery, Jikei University School of Medicine,; Tokyo, Japan.; Although tumor-specific T lymphocytes recognize tumor-associated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercellular adhesive mole
A convenient oxidation of natural glycosphingolipids to their "ceramide acids" for neoglycoconjugation. Bovine serum albumin-glycosylceramide acid conjugates as investigative probes for HIV gp120 coat protein-glycosphingolipid interactions.: J Biol Chem. 1999 Jul 16;274(29):20725-32. Unique Identifier : AIDSLINE MED/99329095; Mylvaganam M; Lingwood CA; Research Institute, Hospital for Sick Children, Toronto, Ontario; M5G 1X8, Canada.; A new method to cleave the double bond of sphingolipids has been developed. Using limited concentrations of KMnO4 and an excess of NaIO4, in a neutral aqueous tert-butanol solvent system gave nearly quantitative yields of the oxidized product. A variety of natural glycosphingolipids (GSLs): GlcC, GalC, SGC, LC, Gb3C,
Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag-Pol transframe protein.: J Biol Chem. 1999 Jul 30;274(31):21539-43. Unique Identifier : AIDSLINE MED/99348275; Paulus C; Hellebrand S; Tessmer U; Wolf H; Krausslich HG; Wagner R; Institut fur Medizinische Mikrobiologie und Hygiene,; Universitat Regensburg, Franz-Josef-Strauss-Allee 11, D-93053; Regensburg, Germany.; The human immunodeficiency virus type-1 (HIV-1) transframe protein p6* is located between the structural and enzymatic domains of the Gag-Pol polyprotein, flanked by the nucleocapsid (NC) and the protease (PR) domain at its amino and carboxyl termini, respectively. Here, we report that recombinant highly purified HIV-
HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.: J Biol Chem. 1999 Jul 30;274(31):21569-74. Unique Identifier : AIDSLINE MED/99348279; Dairaghi DJ; Fan RA; McMaster BE; Hanley MR; Schall TJ; Divisions of Discovery Biology and Molecular Pharmacology,; ChemoCentryx, San Carlos, California 94070, USA.; Uncertainty regarding viral chemokine function is mirrored by an incomplete knowledge of host chemokine receptor usage by the virally encoded proteins. One such molecule is vMIP-I, a C-C type chemokine of undefined function and binding specificity, encoded by the Kaposi s sarcoma herpesvirus HHV-8. We report here that
IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation.: J Clin Invest. 1999 Aug;104(3):317-25. Unique Identifier : AIDSLINE MED/99362492; Teshima T; Hill GR; Pan L; Brinson YS; van den Brink MR; Cooke KR; Ferrara JL; Department of Internal Medicine, University of Michigan Cancer; Center, Ann Arbor 48109-0942, USA.; We recently showed that IL-11 prevents lethal graft-versus-host disease (GVHD) in a murine bone marrow transplantation (BMT) model of GVHD directed against MHC and minor antigens. In this study, we have investigated whether IL-11 can maintain a graft-versus-leukemia (GVL) effect. Lethally irradiated B6D2F1 mice were t
Differential distribution of T lymphocyte subpopulations in the bovine mammary gland during lactation.: J Dairy Sci. 1999 Jul;82(7):1459-64. Unique Identifier : AIDSLINE MED/99344650; Yamaguchi T; Hiratsuka M; Asai K; Kai K; Kumagai K; Department of Animal Science, Faculty of Agriculture, Tohoku; University, Sendai, Japan.; The existence and distribution of T lymphocyte subpopulations in the mammary parenchymal tissue of cows were immunohistochemically detailed during early lactation. CD2+, CD4+, and CD8+ T lymphocytes were localized primarily in the mammary parenchymal tissue. CD8+ T lymphocytes were predominant over CD4+ T lymphocytes
Depressed responsiveness of peripheral blood mononuclear cells to heat-shock proteins in periodontitis patients.: J Dent Res. 1999 Aug;78(8):1393-400. Unique Identifier : AIDSLINE MED/99367881; Petit MD; Wassenaar A; van der Velden U; van Eden W; Loos BG; Academic Centre for Dentistry Amsterdam (ACTA), Department of; Periodontology, The Netherlands.; The extensive homology between human and bacterial heat shock proteins (HSPs) may play a role in autoimmune reactions in periodontitis. Thus, we questioned whether peripheral blood mononuclear cell (PBMC) proliferative responses to HSPs are different between periodontitis patients and control subjects with gingivitis.
Flow cytometric detection of antigen-specific cytokine responses in lung T cells in a murine model of pulmonary inflammation.: J Immunol Methods. 1999 Jun 24;226(1-2):105-18. Unique Identifier : AIDSLINE MED/99336757; Winterrowd GE; Chin JE; Pharmacology Department, Pharmacia and Upjohn, Kalamazoo, MI; 49001, USA.; Multiparameter flow cytometry was used to examine the cytokine responses of antigen-specific T lymphocytes isolated from the lungs of antigen-sensitized mice which developed pulmonary inflammation after aerosol challenge with ovalbumin (OA) (OA/OA). Lung T cells were stimulated in vitro with OA and anti-CD28 monoclona
Interferon-gamma preferentially reduces memory/effector CD8 T lymphocytes in healthy subjects.: J Lab Clin Med. 1999 Aug;134(2):147-53. Unique Identifier : AIDSLINE MED/99371628; de Metz J; Out TA; Wever PC; Reijneke RM; Sprangers F; Sauerwein HP; Romijn JA; ten Berge IJ; Department of Endocrinology and Metabolism, University of; Amsterdam, The Netherlands.; To evaluate the influence of interferon-gamma (IFN-gamma) on leukocyte dynamics, with a focus on naive and memory T cells, we studied 6 healthy subjects twice in a placebo-controlled trial: once after the administration of recombinant human IFN-gamma (rhIFN-gamma; 100 microg/m2 subcutaneously) and at least 4 weeks lat
[Infection and angiomatous cutaneous lesions]: J Mal Vasc. 1999 May;24(2):135-8. Unique Identifier : AIDSLINE MED/99327846; Janier M; Service de Dermatologie, Hopital Saint-Joseph, Paris.; The occurrence of angiomatous cutaneous lesions in the presence of an infective process is not a frequent phenomenon. Most infectious diseases are associated with an exanthematous reaction. The combination of an infective illness and angiomatous lesions is seen essentially in the bartonelloses and in Kaposi s disease.
Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition.: J Exp Med. 1999 Jul 19;190(2):169-76. Unique Identifier : AIDSLINE MED/99362915; Kammer AR; van der Burg SH; Grabscheid B; Hunziker IP; Kwappenberg KM; Reichen J; Melief CJ; Cerny A; Department of Internal Medicine, University Hospital,; Inselspital, 3010 Bern, Switzerland.; Hepatitis C virus (HCV) is thought to be involved in the pathogenesis of autoimmune hepatitis (AIH) type 2, which is defined by the presence of type I antiliver kidney microsome autoantibodies directed mainly against cytochrome P450 (CYP)2D6 and by autoreactive liver infiltrating T cells. Virus-specific CD8(+) cytotox
H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses.: J Exp Med. 1999 Jul 19;190(2):195-204. Unique Identifier : AIDSLINE MED/99362918; Kerksiek KM; Busch DH; Pilip IM; Allen SE; Pamer EG; Section of Infectious Diseases and Section of Immunobiology, Yale; University School of Medicine, New Haven, Connecticut 06520, USA.; Major histocompatibility complex (MHC) class Ib molecules have been implicated in CD8(+) T cell-mediated defenses against intracellular bacterial infection, but the relative importance of MHC class Ib-restricted T cells in antimicrobial immunity is unknown. In this report, we use MHC tetramers to characterize T cell r
Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells.: J Exp Med. 1999 Jul 19;190(2):229-39. Unique Identifier : AIDSLINE MED/99362921; Iwasaki A; Kelsall BL; Mucosal Immunity Section, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892-1890, USA.; Orally administered antigens often generate immune responses that are distinct from those injected systemically. The role of antigen-presenting cells in determining the type of T helper cell response induced at mucosal versus systemic sites is unclear. Here we examine the phenotypic and functional differences between
T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro.: J Exp Med. 1999 Jul 19;190(2):267-80. Unique Identifier : AIDSLINE MED/99362924; Ochi H; Hirani WM; Yuan Q; Friend DS; Austen KF; Boyce JA; Department of Medicine, Harvard Medical School, Women's Hospital,; Boston, MA, USA.; Mast cells (MCs) arise in situ from circulating stem cell factor (SCF)-dependent committed progenitors (PrMCs) and accumulate at sites of allergic mucosal inflammation. We hypothesized that human (h)PrMCs and their mature counterparts might share overlapping patterns of chemokine and cytokine receptor utilization with
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation.: J Exp Med. 1999 Aug 2;190(3):355-66. Unique Identifier : AIDSLINE MED/99359489; van Elsas A; Hurwitz AA; Allison JP; Howard Hughes Medical Institute, Cancer Research Laboratory,; Department of Molecular and Cellular Biology, University of; California, Berkeley 94720-3200, USA.; We examined the effectiveness of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade, alone or in combination with a granulocyte/macrophage colony-stimulating factor (GM-CSF)-expressing tumor cell vaccine, on rejection of the highly tumorigenic, poorly immunogenic murine melanoma B16-BL6. Recently establishe
Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis.: J Exp Med. 1999 Aug 2;190(3):385-98. Unique Identifier : AIDSLINE MED/99359492; Rabinovich GA; Daly G; Dreja H; Tailor H; Riera CM; Hirabayashi J; Chernajovsky Y; Immunology Department, Faculty of Chemical Sciences, National; University of Cordoba 5000, Argentina.; Galectin-1 (GAL-1), a member of a family of conserved beta-galactoside-binding proteins, has been shown to induce in vitro apoptosis of activated T cells and immature thymocytes. We assessed the therapeutic effects and mechanisms of action of delivery of GAL-1 in a collagen-induced arthritis model. A single injection
Association of GB virus C (GBV-C)/hepatitis G virus (HGV) with haematological diseases of different malignant potential.: J Med Virol. 1999 Apr;57(4):361-6. Unique Identifier : AIDSLINE MED/99186908; Pavlova BG; Heinz R; Selim U; Tuchler H; Pittermann E; Eder G; L. Boltzmann Institute for Leukemia Research and Haematology,; Vienna, Austria. lbifluh@adis.at; Among risk groups for GB virus C (GBV-C)/HGV infection, patients with haematological diseases are particularly exposed due to the combination of transfusional support and immunodeficiency status. To examine any association between GBV-C/HGV positivity and different malignancy potential of hematological diseases, we in
Influence of CD4+ lymphocyte counts on GB virus C/hepatitis G virus carriership in HIV-positive individuals.: J Med Virol. 1999 Apr;57(4):367-9. Unique Identifier : AIDSLINE MED/99186909; Goubau P; Liu HF; Goderniaux E; Burtonboy G; Virology, Cliniques Universitaires St. Luc, Universite; Catholique de Louvain, Brussels, Belgium. goubau@mblg.ucl.ac.be; The duration of the GB virus C or hepatitis G virus (GBV-C/HGV) carriership varies according to the patient group studied. The immune competence of the host may be important. GBV-C/ HGV was studied in human immunodeficiency virus (HIV)-infected persons and an attempt was made to correlate the presence of viral RNA or
Unintegrated HIV-1 circular 2-LTR proviral DNA as a marker of recently infected cells: relative effect of recombinant CD4, zidovudine, and saquinavir in vitro.: J Med Virol. 1999 Jun;58(2):165-73. Unique Identifier : AIDSLINE MED/99266896; Panther LA; Coombs RW; Aung SA; dela Rosa C; Gretch D; Corey L; Department of Laboratory Medicine, University of Washington,; Seattle 98195, USA.; Unintegrated HIV-1 proviral DNA is one of the earliest detectable forms of HIV-1, and the influence of an antiretroviral drug on its appearance may reflect the efficacy of that agent in preventing infection of new cells. We characterized the dynamics of HIV-1 p24 (p24) antigen production, HIV-1 gag DNA, tandem long-te
HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity.: J Neurochem. 1999 Aug;73(2):578-86. Unique Identifier : AIDSLINE MED/99355007; Maggirwar SB; Tong N; Ramirez S; Gelbard HA; Dewhurst S; Department of Microbiology and Immunology, University of; Rochester Medical Center, New York 14642, USA.; Human immunodeficiency virus type 1 (HIV-1) Tat induces neuronal apoptosis. To examine the mechanism(s) that contribute to this process, we studied Tat s effects on glycogen synthase kinase-3beta (GSK-3beta), an enzyme that has been implicated in the regulation of apoptosis. Addition of Tat to rat cerebellar granule n
Molecular determinants of the interaction between the C-terminal domain of Alzheimer's beta-amyloid peptide and apolipoprotein E alpha-helices.: J Neurochem. 1999 Aug;73(2):758-69. Unique Identifier : AIDSLINE MED/99355028; Lins L; Thomas-Soumarmon A; Pillot T; Vandekerchkhove J; Rosseneu M; Brasseur R; INSERM U. 10, Hopital Bichat-Claude Bernard, Paris, France.; In a previous work, we predicted and demonstrated that the 29-42-residue fragment of beta-amyloid peptide (Abeta peptide) has in vitro capacities close to those of the tilted fragment of viral fusion proteins. We further demonstrated that apolipoprotein E2 and E3 but not apolipoprotein E4 can decrease the fusogenic ac
Gp-41-mediated astrocyte inducible nitric oxide synthase mRNA expression: involvement of interleukin-1beta production by microglia.: J Neurosci. 1999 Aug 1;19(15):6468-74. Unique Identifier : AIDSLINE MED/99343812; Hu S; Ali H; Sheng WS; Ehrlich LC; Peterson PK; Chao CC; Institute for Brain and Immune Disorders, Minneapolis Medical; Research Foundation and the University of Minnesota Medical; School, Minneapolis, Minnesota 55404, USA.; Mechanisms underlying human immunodeficiency virus-1 encephalopathy are not completely known; however, recent studies suggest that the viral protein gp41 may be neurotoxic via activation of inducible nitric oxide synthase (iNOS) in glial cells. In the present study, we investigated the NO-generating activity of primar
Prevalence of HIV-associated periodontitis and chronic periodontitis in a southeastern US study group.: J Public Health Dent. 1998 Fall;58(4):294-300. Unique Identifier : AIDSLINE MED/99319185; McKaig RG; Thomas JC; Patton LL; Strauss RP; Slade GD; Beck JD; Department of Dental Ecology, University of North Carolina,; Chapel Hill 27599-7450, USA. rosemary_mckaig@unc.edu; OBJECTIVES: This study estimates factors associated with the prevalence of HIV-associated periodontal diseases (HIV-P) and the severity and extent of periodontitis in HIV-infected adults from North Carolina (NC). METHODS: Data are derived from a cross-sectional study of HIV-infected adults (total n = 326, dentate n =
Infant growth after in utero exposure to zidovudine [letter]: JAMA. 1999 Aug 11;282(6):527-9. Unique Identifier : AIDSLINE MED/99377921; Zuccotti GV; Agostoni C; D'Auria E; Torcoletti M; Riva E
Trends in perinatal transmission of HIV/AIDS in the United States [see comments]: JAMA. 1999 Aug 11;282(6):531-8. Unique Identifier : AIDSLINE MED/99377923; Lindegren ML; Byers RH Jr; Thomas P; Davis SF; Caldwell B; Rogers M; Gwinn M; Ward JW; Fleming PL; Division of HIV/AIDS Prevention: Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.; mll3@cdc.gov; CONTEXT: Since 1994, the US Public Health Service (PHS) has recommended routine, voluntary prenatal human immunodeficiency virus (HIV) testing and zidovudine therapy to reduce perinatal HIV transmission. OBJECTIVE: To describe trends in incidence of perinatal AIDS and factors contributing to these trends, particularly
Can perinatal HIV infection be eliminated in the United States? [editorial; comment]: JAMA. 1999 Aug 11;282(6):577-9. Unique Identifier : AIDSLINE MED/99377930; Mofenson LM
JAMA Patient Page. HIV/AIDS.: JAMA. 1999 Aug 11;282(6):606. Unique Identifier : AIDSLINE MED/99377933
Victim-blaming tendency toward people with AIDS among college students.: J Soc Psychol. 1999 Jun;139(3):300-8. Unique Identifier : AIDSLINE MED/99338807; Lee MY; Campbell AR; Mulford CL; Department of Sociology, Iowa State University, Ames 50011-1070,; USA.; The victim-blaming tendency toward people with AIDS was examined in relation to gender, fraternity-sorority affiliation, classification (freshmen vs. others), religion (Catholic vs. others), and academic major (business college vs. others) in a survey of 818 students at a midwestern state university in the
[Bronchiectasia in HIV-positive patients]: Medicina (B Aires). 1999;59(1):67-70. Unique Identifier : AIDSLINE MED/99278740; Monteverde A; Gonzalez A; Fernandez A; Del Valle E; Micele C; Laplume H; Departamento de Medicina, Hospital Nacional Alejandro Posadas,; Haedo. monteverde@intramed.net.ar; Between July 1995 and July 1997 we diagnosed bronchiectasis confirmed by CT scan chest in 25 (18 men and 7 women) out of 295 hospitalised patients with HIV infection who suffered from lower respiratory infection. Median age at time of diagnosis of bronchiectasis was 32 years old. The patients were mostly intravenous d
Amprenavir: a new HIV protease inhibitor.: Med Lett Drugs Ther. 1999 Jul 16;41(1057):64-6. Unique Identifier : AIDSLINE MED/99365825
[Progressive multifocal leukoencephalopathy]: Unique Identifier : AIDSLINE MED/99336531; Wasmuth JC; Wasmuth-Pietzuch A; Spengler U; Rockstroh JK; PATHOGENESIS: Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous system caused by infection and reactivation of JC-virus. About 5% of all HIV-infected patients develop this fatal disease. Although pathogenesis is not completely understood, progressive multifocal leukoencephalo
Interactions of HIV protease inhibitors with ATP-dependent drug export proteins.: Mol Pharmacol. 1999 Aug;56(2):383-9. Unique Identifier : AIDSLINE MED/99348415; Gutmann H; Fricker G; Drewe J; Toeroek M; Miller DS; Division of Gastroenterology and Clinical Pharmacology,; Department of Internal Medicine, University Clinic (Kantonsspital; and Children's Hospital), Basel, Switzerland.; We used renal proximal tubules from a teleost fish (killifish; Fundulus heteroclitus), fluorescent substrates and confocal microscopy to study the interactions between human immunodeficiency virus protease inhibitors and drug-transporting ATPases. Both saquinavir an
Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is important for nuclear import and activity of retrotransposon Tf1.: Mol Cell Biol. 1999 Aug;19(8):5768-84. Unique Identifier : AIDSLINE MED/99340273; Balasundaram D; Benedik MJ; Morphew M; Dang VD; Levin HL; Laboratory of Eukaryotic Gene Regulation, National Institute of; Child Health and Human Development, National Institutes of; Health, Bethesda, Maryland, USA.; The long terminal repeat (LTR)-containing retrotransposon Tf1 propagates within the fission yeast Schizosaccharomyces pombe as the result of several mechanisms that are typical of both retrotransposons and retroviruses. To identify host factors that contribute to the transposition process, we mutagenized cultures of S
Drug could slash rate of perinatal HIV [news]: Nature. 1999 Jul 22;400(6742):304. Unique Identifier : AIDSLINE MED/99359048
Dating the origin of HIV-1 subtypes [letter]: Nature. 1999 Jul 22;400(6742):325-6. Unique Identifier : AIDSLINE MED/99359056; Goudsmit J; Lukashov VV
[Therapeutic options for HIV-infection should lead to increased utilization of HIV tests (letter)]: Ned Tijdschr Geneeskd. 1999 Jun 26;143(26):1395-6. Unique Identifier : AIDSLINE MED/99345010; Boer K
[Therapeutic options for HIV-infections should lead to increased utilization of HIV tests (letter)]: Ned Tijdschr Geneeskd. 1999 Jun 26;143(26):1396-7. Unique Identifier : AIDSLINE MED/99345011; Kleiverda G; van Crimpen R; Flikweert S
Spinal disease in neurologically symptomatic HIV-positive patients.: Neuroradiology. 1999 May;41(5):360-8. Unique Identifier : AIDSLINE MED/99306264; Taber KH; Hayman LA; Shandera WX; Diaz-Marchan PJ; Omessi T; Department of Radiology, Baylor College of Medicine, Houston, TX; 77030-3498, USA. taber@bcm.tmc.edu; We review the MRI findings of human immunodeficiency virus (HIV)-positive patients with spinal symptoms and review the literature. In 23 consecutive HIV-positive patients presenting with acute neurologic complaints thought to be referable to the spine, we reviewed spinal MRI, medical charts, and laboratory, patholog
Teens & AIDS. The education gap.: N J Med. 1999 Jul;96(7):29-31. Unique Identifier : AIDSLINE MED/99361351; Levinson RK
Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 rex mutants.: Oncogene. 1999 Jul 15;18(28):4080-90. Unique Identifier : AIDSLINE MED/99361942; Heger P; Rosorius O; Hauber J; Stauber RH; Institute for Medical and Clinical Virology, University of; Erlangen-Nurnberg, Erlangen, Germany.; The HTLV-1 Rex protein is an essential shuttle protein required for nuclear export of unspliced and incompletely-spliced viral RNAs. Several trans-dominant (TD) mutant Rex proteins have been reported, however, the mechanism of trans-dominance is not known. We compared TD Rex mutants and found that a natural occurring
Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site.: Oncogene. 1999 Jul 15;18(28):4137-43. Unique Identifier : AIDSLINE MED/99361948; Suzuki T; Uchida-Toita M; Yoshida M; Department of Cellular and Molecular Biology, Institute of; Medical Science, The University of Tokyo, Japan.; Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent transcriptional regulator which can activate or repress specific cellular genes and has been proposed to contribute to leukemogenic processes in adult T-cell leukemia. The molecular mechanism of Tax-mediated trans-activation has been well investiga
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.: Oncogene. 1999 Jul 22;18(29):4182-90. Unique Identifier : AIDSLINE GENBANK/U33821; De Valck D; Jin DY; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang KT; Beyaert R; Department of Molecular Biology, Flanders Interuniversity; Institute for Biotechnology and University of Gent, Belgium.; A20 is a Cys2/Cys2 zinc finger protein which is induced by a variety of inflammatory stimuli and which has been characterized as an inhibitor of cell death by a yet unknown mechanism. In order to clarify its molecular mechanism of action, we used the yeast two-hybrid system to screen for proteins that interact with A2
The systemic immune response of BALB/c mice infected with larval Taenia crassiceps is a mixed Th1/Th2-type response.: Parasitology. 1999 Jun;118 ( Pt 6):623-33. Unique Identifier : AIDSLINE MED/99334542; Toenjes SA; Spolski RJ; Mooney KA; Kuhn RE; Department of Biology, Wake Forest University, Winston-Salem, NC; 27109, USA.; The subsets of lymphocytes and cytokines regulating the site-specific immune response in experimental cysticercosis (Taenia crassiceps) are not known. This study investigated the cells present at the site of infection (PECs) using flow cytometry and measured the cytokines produced by these cells through 50 days of inf
Issues related to human immunodeficiency virus transmission in schools, child care, medical settings, the home, and community. American Academy of Pediatrics. Committee of Pediatric AIDS and Committee on Infectious Diseases.: Pediatrics. 1999 Aug;104(2 Pt 1):318-24. Unique Identifier : AIDSLINE MED/99359662; Current recommendations of the American Academy of Pediatrics (AAP) for infection control practices to prevent transmission of blood-borne pathogens, including human immunodeficiency virus (HIV) in hospitals, other medical settings, schools, and child care facilities, are reviewed and explained. Hand-washing is essent
An addict who wants to detoxify.: Practitioner. 1998 Nov;242(1592):735-6, 739-40. Unique Identifier : AIDSLINE MED/99370476; Smith P; Gerada C; Kemp K; Substance Misuse Services, Camden & Islington Community NHS; Trust.
[An unusual cause of ambiguous HIV-1 western blot pattern (letter)]: Presse Med. 1999 Jul 3-10;28(24):1293-4. Unique Identifier : AIDSLINE MED/99370649; Gerome P; Garnotel E; Teyssou R; Morillon M; Blanchard de Vaucouleurs A
[Monitoring and secondary effects of transfusion of labile blood products]: Presse Med. 1999 Jul 3-10;28(24):1327-35. Unique Identifier : AIDSLINE MED/99370656; Lapierre V; Herve P; Unite de Medecine Transfusionnelle et d'Hemovigilance,; Institut Gustave Roussy, Villejuif. lapierre@igr.fr; VIRUS RISKS: Since 1991, the medical community has focused what can be termed transfusion phobia on transmissible viral diseases. Such diseases do not however reflect the overall risk of transfusion. The residual virus risk is the risk of not detecting a viral disease in the donor population which is transmissible by
Antiviral activities against HSV-1, HCMV, and HIV-1 of rhamnan sulfate from Monostroma latissimum [letter]: Planta Med. 1999 Jun;65(5):439-41. Unique Identifier : AIDSLINE MED/99346885; Lee JB; Hayashi K; Hayashi T; Sankawa U; Maeda M; Rhamnan sulfate (RS), a natural sulfated polysaccharide isolated from Monostroma latissimum, showed potent inhibitory effects on the virus replication of herpes simplex virus type 1 (HSV-1), human cytomegalovirus (HCMV), and human immunodeficiency virus type 1 (HIV-1) in vitro. The
Azaanthraquinone: an antimicrobial alkaloid from Mitracarpus scaber [letter]: Planta Med. 1999 Jun;65(5):447-8. Unique Identifier : AIDSLINE MED/99346886; Okunade AL; Clark AM; Hufford CD; Oguntimein BO; An ethanolic extract of the aerial parts of Mitracarpus scaber demonstrated good antimicrobial activity. Bioassay directed fractionation of this extract led to the isolation of benz[g]isoquinoline-5,10-dione (1) as an active component. Compound 1 showed significant in vitro inhibitory activity against the AIDS-related
Delivering mental health care to HIV-positive individuals. A comparison of two models.: Psychosomatics. 1999 Jul-Aug;40(4):321-4. Unique Identifier : AIDSLINE MED/99331289; Gomez MF; Klein DA; Sand S; Marconi M; O'Dowd MA; Department of Psychiatry, Montefiore Medical Center, Bronx, New; York 10467, USA.; Data on initial psychiatric evaluations performed in 1995 were compared to assess whether psychiatric consultation for human immunodeficiency virus (HIV)-positive/acquired immunodeficiency syndrome (AIDS) patients provided on-site in an infectious disease (ID) clinic improved compliance and were preferred by staff to
[Hodgkin's disease and non-Hodgkin lymphomas]: Unique Identifier : AIDSLINE MED/99351350; Ojeda Gutierrez E; Servicio de Hematologia y Hemoterapia, Hospital La Paz, Madrid.
[Community-acquired pneumonia caused by Staphylococcus aureus in non-HIV infected adult patients]: Rev Pneumol Clin. 1999 Apr;55(2):83-7. Unique Identifier : AIDSLINE MED/99346605; Germaud P; Caillet S; Caillon J; Allenet MC; Service de Pneumologie, Hopital G. & R. Laennec, Nantes.; Staphylococcus aureus is the sixth frequent cause of community-acquired pneumonia. We report 19 cases of staphylococcal pneumonia in 3 women and 16 men, mean age 55 years. Predisposing factors were: age > 65 years, alcoholism, chronic bronchopulmonary disease, immunodepression, renal failure, diabetes. The portal was
Change in the Th1/Th2 phenotype of memory T-cell clones from rheumatoid arthritis synovium.: Scand J Immunol. 1999 Jul;50(1):1-9. Unique Identifier : AIDSLINE MED/99333826; Aarvak T; Chabaud M; Kallberg E; Miossec P; Natvig JB; Institute for Immunology and Rheumatology, The National Hospital,; Oslo, Norway.; The stability of established memory T helper (Th)1/Th2 cells in chronic inflammatory diseases is not clear, and a shift of the cytokine balance could control chronic inflammation. In order to study the regulation of the Th phenotype of memory T cells, polyclonal T-cell lines and clones with a Th1, Th0 or Th2 phenotype
Inflammation and severe demyelination in the peripheral nervous system induced by the intraneural injection of recombinant mouse interleukin-12.: Scand J Immunol. 1999 Jul;50(1):39-44. Unique Identifier : AIDSLINE MED/99333832; Pelidou SH; Deretzi G; Zou LP; Quiding C; Zhu J; Division of Geriatric Medicine, Karolinska Institute, Huddinge; Hospital, Sweden.; Inflammatory cytokines appear to be involved in damage to Schwann cells, myelin and axons, although the exact role of the different cytokines is uncertain. The direct injection model offers a new and simplified way of examining the mechanisms of early inflammation in the peripheral nervous system. The present study wa
Specific immune response to human immunodeficiency virus (HIV)-1 in patients assessed through the production of interferon-gamma and interleukin-4 in HIV-1 p24-activated whole blood cultures: relationship with the viral load in plasma.: Scand J Immunol. 1999 Jul;50(1):83-90. Unique Identifier : AIDSLINE MED/99333838; Hober D; Benyoucef S; Chieux V; De Groote D; De La Tribonniere X; Bocket L; Lion G; Mouton Y; Wattre P; Laboratoire de virologie, Institut Gernez Rieux, CHU, 59037,; Lille cedex, France.; We studied the in vitro HIV-1 antigen-stimulated production of IFN-gamma and IL-4 in HIV-1-infected patients and its relationship with viral replication as assessed through the plasma level of HIV-1 RNA. The levels of IFN-gamma and IL-4 were higher in supernatants of stimulated whole blood cultures than in stimulated
Report of new hepatitis virus has researchers intrigued and upset [news]: Science. 1999 Jul 30;285(5428):644-5. Unique Identifier : AIDSLINE MED/99377862; Cohen J
AIDS vaccines. Glimmerings of hope from the bottom of the well [news]: Science. 1999 Jul 30;285(5428):656-7. Unique Identifier : AIDSLINE MED/99377869; Cohen J
Lentiviral vectors--the promise of gene therapy within reach?: Science. 1999 Jul 30;285(5428):674-6. Unique Identifier : AIDSLINE MED/99377878; Amado RG; Chen IS; Department of Microbiology and Immunology, UCLA School of; Medicine and UCLA AIDS Institute, Los Angeles, CA 90095, USA.; ramado@ucla.edu
Association of lamivudine resistance in recurrent hepatitis B after liver transplantation with advanced hepatic fibrosis.: Transplantation. 1999 Jul 27;68(2):232-6. Unique Identifier : AIDSLINE MED/99367005; Ben-Ari Z; Pappo O; Zemel R; Mor E; Tur-Kaspa R; Liver Institute and Department of Medicine D, Rabin Medical; Center, Petah Tiqva, Israel.; BACKGROUND: Orthotopic liver transplantation (OLT) in patients with hepatitis B virus (HBV) infection is known to be associated with a high recurrence rate and poor prognosis. Lamivudine , a nucleoside analogue, is a potent inhibitor of HBV replication
Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2.: Transplantation. 1999 Jul 27;68(2):288-93. Unique Identifier : AIDSLINE MED/99367015; Onodera K; Chandraker A; Volk HD; Ritter T; Lehmann M; Kato H; Sayegh MH; Kupiec-Weglinski JW; Department of Surgery, Brigham and Women's Hospital, Harvard; Medical School, Boston, Massachusetts, USA.; BACKGROUND: CD4-targeted therapy or blocking of CD28-B7 T-cell costimulation may produce indefinite cardiac allograft survival in presensitized rats. This study analyzes the immune events associated with tolerance pathways after the blockade of activation signal 1 (CD4 monoclonal antibody [mAb]) or signal 2 (CTLA4Ig).
Concomitant human immunodeficiency virus protease inhibitor therapy markedly reduces tacrolimus metabolism and increases blood levels.: Transplantation. 1999 Jul 27;68(2):307-9. Unique Identifier : AIDSLINE MED/99367020; Sheikh AM; Wolf DC; Lebovics E; Goldberg R; Horowitz HW; Department of Medicine, New York Medical College, Valhalla, USA.; We present the case of a patient with hepatitis C-induced cirrhosis and concomitant human immunodeficiency virus infection who underwent orthotopic liver transplantation. The patient developed severe, prolonged tacrolimus toxicity in the presence of human immunodeficiency virus
Treatment of post-transfusion graft-versus-host disease with nafmostat mesilate, a serine protease inhibitor.: Vox Sang. 1999;76(4):241-6. Unique Identifier : AIDSLINE MED/99324238; Ryo R; Saigo K; Hashimoto M; Kohsaki M; Yasufuku M; Watanabe N; Okada M; Tadokoro K; Juji T; Division of Blood Transfusion, Kobe University Hospital, Japan.; tyo@med.kobe-u.ac.jp; BACKGROUND: Cytotoxic T lymphocytes from donors are thought to injure the target organs in post-transfusion graft-versus-host disease (PT-GVHD) through perforin-granzyme- and Fas-dependent cell killings. The protease involved is a serine protease, and nafmostat mesilate (NM), a serine protease inhibitor, has been foun
[Maternal anti-paternal reactivity--depends on etiology]: Zentralbl Gynakol. 1999;121(4):202-5. Unique Identifier : AIDSLINE MED/99283526; Schutt C; Institut fur Immunologie und Transfusionsmedizin,; Ernst-Moritz-Arndt-Universitat Greifswald.; Since TH1-cytokines compromise pregnancy and TH2-cytokines are produced at the maternal-fetal interface one can hypothesize that TH2-cytokines improve fetal survival. Cytotoxic T- or NK-cells are unable to recognize MHCI/II-negative trophoblast or become inactivated by HLA-G expression, respectively. Normal delivery a
[A cryptococcal granuloma of the midbrain]: Zh Vopr Neirokhir Im N N Burdenko. 1999 Apr-Jun;(2):33-6. Unique Identifier : AIDSLINE MED/99349030; Konovalov AN; Pitskhelauri DI; Korshunov AG; Arutiunov NV; Imshenetskaia VF; Khukhlaeva EA; The paper describes the most infrequent case of cryptococcal granuloma of the midbrain in a HIV-negative female patient aged 41 years. The patient with midbrain lesion without signs of meningitis was found to have a bulky midbrain opercular formation that was regarded as a nodal glioma. The diagnosis of cryptococcal g
Sulfadiazine-induced crystalluria and renal failure in a patient with AIDS.: J Am Board Fam Pract. 1999 May-Jun;12(3):243-8. Unique Identifier : AIDSLINE MED/99321345; Dong BJ; Rodriguez RA; Goldschmidt RH; Department of Clinical Pharmacy, University of California at San; Francisco General Hospital, USA.
Trimethoprim-sulfamethoxazole therapy in outpatients: is hyperkalemia a significant problem?: Am J Nephrol. 1999;19(3):389-94. Unique Identifier : AIDSLINE MED/99321456; Alappan R; Buller GK; Perazella MA; Staywell Health Center, Waterbury, Conn., USA.; A prospective, randomized clinical study was undertaken to determine the effect of standard-dose trimethoprim-sulfamethoxazole combination treatment on serum potassium concentrations in outpatients treated in an ambulatory clinic. Ninety-seven patients were treated with oral antibiotics for a variety of infections. Fi
Name-based reporting of HIV infection [letter]: Am J Public Health. 1999 Aug;89(8):1271-3. Unique Identifier : AIDSLINE MED/99361590; Wortley PM; Lehman JS; Fleming PL
Markedly high seroprevalence of hepatitis B virus infection in comparison to hepatitis C virus and human T lymphotropic virus type-1 infections in selected Solomon Islands populations.: Am J Trop Med Hyg. 1999 Jul;61(1):85-91. Unique Identifier : AIDSLINE MED/99359009; Furusyo N; Hayashi J; Kakuda K; Sawayama Y; Ariyama I; Eddie R; Kashiwagi S; Department of General Medicine, Kyushu University Hospital,; Fukuoka, Japan.; To determine the prevalences of hepatitis B virus (HBV), hepatitis C virus (HCV), and human T lymphotropic virus type-1 (HTLV-1) infections in residents of the Solomon Islands , we surveyed 1,610 serum samples from 1,113 outpatients
HIV-associated eosinophilic folliculitis in an infant.: Am J Dermatopathol. 1999 Jun;21(3):241-6. Unique Identifier : AIDSLINE MED/99306713; Ramdial PK; Morar N; Dlova NC; Aboobaker J; Department of Pathology, Faculty of Medicine, University of; Natal, South Africa.; HIV-associated eosinophilic folliculitis (HIV-EF), which is a well-known entity in adults, has not been described in children. Although Ofuji s disease (OD) or eosinophilic pustular folliculitis (EPF) has been described in children and shares histopathologic features with HIV-EF, it is a distinct entity with character
Immune dysfunction during alcohol consumption and murine AIDS: the protective role of dehydroepiandrosterone sulfate.: Alcohol Clin Exp Res. 1999 May;23(5):856-62. Unique Identifier : AIDSLINE MED/99297816; Lee J; Sepulveda RT; Jiang S; Zhang Z; Inserra P; Zhang Y; Hosseini S; Watson RR; Arizona Prevention Center, University of Arizona, Tucson 85724,; USA.; Acquired immune deficiency syndrome (AIDS) is a clinical disorder caused by the human immunodeficiency virus (HIV) after development of severe immunosuppressive changes. Chronic ethanol (EtOH) consumption accentuates the severity of murine AIDS (MAIDS). Because hormone production is often suppressed by chronic EtOH in
Ethanol suppression of the functional state of polymorphonuclear leukocytes obtained from uninfected and simian immunodeficiency virus infected rhesus macaques.: Alcohol Clin Exp Res. 1999 May;23(5):878-84. Unique Identifier : AIDSLINE MED/99297819; Stoltz DA; Zhang P; Nelson S; Bohm RP Jr; Murphey-Corb M; Bagby GJ; Department of Medicine, Alcohol Research Center, Louisiana State; University Medical Center, New Orleans 70112-1393, USA.; BACKGROUND: Human immunodeficiency virus (HIV) infection and alcohol abuse frequently coexist in the host and are known to suppress individually the host response to a variety of opportunistic infections. METHODS: This study examined the effects of in vitro ethanol exposure on several functions of polymorphonuclear le
Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man.: Ann Emerg Med. 1999 Aug;34(2):282-4. Unique Identifier : AIDSLINE MED/99353789; Roy PM; Gouello JP; Pennison-Besnier I; Chennebault JM; Department of Emergency Medicine, University Hospital of Angers,; France. pmroy@chu-angers.fr; Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed
Plasma HIV viral load in patients with hemophilia and late-stage HIV disease: a measure of current immune suppression. Multicenter Hemophilia Cohort Study.: Ann Intern Med. 1999 Aug 17;131(4):256-64. Unique Identifier : AIDSLINE MED/99369422; Engels EA; Rosenberg PS; O'Brien TR; Goedert JJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, Maryland 20822,; USA. engelse@exchange.nih.gov; BACKGROUND: For patients infected with HIV, plasma HIV viral load in early disease predicts long-term prognosis. However, the implications of viral load measurements late in HIV disease are uncertain. OBJECTIVE: To evaluate the relation between plasma HIV viral load and subsequent risk for disease progression in patie
Reversal of protease inhibitor-related visceral abdominal fat accumulation with recombinant human growth hormone [letter]: Ann Intern Med. 1999 Aug 17;131(4):313-4. Unique Identifier : AIDSLINE MED/99369436; Mauss S; Wolf E; Jaeger H
Three-colour, one-tube flow cytometric method for enumeration of CD4+ and CD8+ lymphocytes.: Ann Clin Biochem. 1999 Mar;36 ( Pt 2):196-201. Unique Identifier : AIDSLINE MED/99298874; Janssen WC; Hoffmann JJ; Department of Clinical Laboratories, Catharina Hospital,; Eindhoven, The Netherlands.; We investigated the usefulness of a one-tube, three-colour flow cytometric method for enumerating CD4+ and CD8+ lymphocytes. This method does not use any control antibodies and we compared it to the standard methods using either control and CD14/CD45 antibodies or control antibodies only on 38 blood samples from healt
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice.: Arthritis Rheum. 1999 Aug;42(8):1635-43. Unique Identifier : AIDSLINE MED/99374528; Sasai M; Saeki Y; Ohshima S; Nishioka K; Mima T; Tanaka T; Katada Y; Yoshizaki K; Suemura M; Kishimoto T; Osaka University Medical School, Suita, Japan.; OBJECTIVE: To investigate the roles of interleukin-6 (IL-6) in the pathogenesis of rheumatoid arthritis (RA) by studying its effect on murine collagen-induced arthritis (CIA). METHODS: IL-6-deficient (IL-6-/-) mice with a genetic background of susceptibility to CIA were generated by backcrossing them with DBA/1J mice
Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus.: Arthritis Rheum. 1999 Aug;42(8):1644-8. Unique Identifier : AIDSLINE MED/99374529; Akahoshi M; Nakashima H; Tanaka Y; Kohsaka T; Nagano S; Ohgami E; Arinobu Y; Yamaoka K; Niiro H; Shinozaki M; Hirakata H; Horiuchi T; Otsuka T; Niho Y; Kyushu University Medical School, Fukuoka, Japan.; OBJECTIVE: To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE). METHODS: The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who h
Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses.: DNA Cell Biol. 1999 Jul;18(7):521-31. Unique Identifier : AIDSLINE MED/99360933; Sykes KF; Johnston SA; Center for Biomedical Inventions, Department of Internal; Medicine, The University Texas-Southwestern Medical Center,; Dallas 75235-8573, USA. sykes@ryburn.swmed.edu; The development of an effective HIV vaccine is both a pressing and a formidable problem. The most encouraging results to date have been achieved using live-attenuated immunodeficiency viruses. However, the frequency of pathogenic breakthroughs has been a deterrent to their development. We suggest that expression libra
Modulation of ex vivo cytokine production by splenocytes using in vitro combined therapeutics in murine retroviral model.: Unique Identifier : AIDSLINE MED/99360939; Kang LC; Kerben MJ; Ugen KE; Specter SC; Altered levels of Type 1 and Type 2 cytokines are important in retrovirus-induced immunosuppression. The combination of immunostimulatory agents with antiviral drugs alters the course of murine retroviral infections. Previously, it was demonstrated that in vitro treatment of noninfected splenocytes and in vivo treatme
CTLA-4 and T cell activation.: Curr Opin Immunol. 1999 Jun;11(3):294-300. Unique Identifier : AIDSLINE MED/99306927; Oosterwegel MA; Greenwald RJ; Mandelbrot DA; Lorsbach RB; Sharpe AH; Immunology Research Division, Department of Pathology, Brigham; and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.; moosterwegel@rics.bwh.harvard.edu; The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has
Oral cavity and oropharyngeal tumors in human immunodeficiency virus-positive patients: acute response to radiation therapy.: Arch Otolaryngol Head Neck Surg. 1999 Aug;125(8):873-6. Unique Identifier : AIDSLINE MED/99375964; Kao GD; Devine P; Mirza N; Department of Radiation Oncology, Philadelphia Veterans Affairs; Medical Center, PA, USA. kao@xrt.upenn.edu; BACKGROUND: The survival of patients with human immunodeficiency virus (HIV) has improved considerably with modern medical management. However, there remains surprisingly little information on treating head and neck neoplasms in HIV-positive patients. OBJECTIVE: To report our recent experience treating oral cavity and
Abdominal tuberculous abscesses in AIDS patients: percutaneous treatment.: Rev Esp Enferm Dig. 1999 Jun;91(6):439-46. Unique Identifier : AIDSLINE MED/99362459; Rendon Unceta P; Amaya Vidal A; Porcel Martin A; Macias Rodriguez MA; Soria de la Cruz MJ; Martin Herrera L; Servicio de Aparato Digestivo, Hospital Universitario "Puerta del; Mar", Cadiz, 11009, Espana.; OBJECTIVE: to analyze certain epidemiological and ultrasonographic features, and the response to percutaneous treatment, of abdominal tuberculous abscesses in patients with human acquired immunodeficiency syndrome. METHODS: we reviewed the clinical records and ultrasonographic findings in 7 patients with abdominal tub
The crystal structure of the SIV gp41 ectodomain at 1.47 A resolution.: J Struct Biol. 1999 Jun 15;126(2):131-44. Unique Identifier : AIDSLINE PDB/1QBZ; Yang ZN; Mueser TC; Kaufman J; Stahl SJ; Wingfield PT; Hyde CC; Laboratory of Structural Biology Research, National Institute of; Arthritis and Musculoskeletal and Skin Diseases, Bethesda,; Maryland 20892, USA.; Cell membrane fusion by human (HIV) and simian (SIV) immunodeficiency viruses is mediated by the envelope glycoproteins gp120 and gp41. Although the precise mechanism of the fusion process is unknown, the ectodomain of gp41 is thought to undergo dramatic rearrangement from its prefusogenic state. To elucidate this pro
Bibliography of the current world literature. Infectious arthritis and immune dysfunction.: Curr Opin Rheumatol. 1999 Jul;11(4):B116-23. Unique Identifier : AIDSLINE MED/99337197
Psoriatic arthritis and the spectrum of syndromes related to the SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome.: Curr Opin Rheumatol. 1999 Jul;11(4):251-6. Unique Identifier : AIDSLINE MED/99337185; Winchester R; Division of Autoimmune and Molecular Diseases, Columbia; University College of Physicians and Surgeons, New York, New York; 10032, USA.; During the past year, the increasing use of nuclear magnetic resonance imaging techniques, with their ability to delineate cartilage and ligamentous structures and to identify edema, are providing a radical improvement in ascertainment of musculoskeletal abnormalities, although their significance remains incompletely
A 10-year-old boy, HIV positive, develops progressive weakness [clinical conference]: Pediatr Neurosurg. 1999 Apr;30(4):211-7. Unique Identifier : AIDSLINE MED/99350186; George T; Grant J; DeLeon G; Darling CF; Department of Surgery, Division of Neurosurgery, Duke University; Medical School, Durham, N.C., USA.
In vitro differentiation of a CD4/CD8 double-positive equivalent thymocyte subset in adult Xenopus.: Int Immunol. 1999 Apr;11(4):499-508. Unique Identifier : AIDSLINE MED/99254781; Robert J; Cohen N; Department of Microbiology and Immunology, University of; Rochester Medical Center, NY 14642, USA.; The thymus is the major site of selection and differentiation of T cells in mammals and birds. To begin to study the evolution of thymocyte differentiation, we have developed, in the frog Xenopus, an in vitro system that takes advantage of cortical thymocyte antigen (CTX), a recently discovered T cell antigen whose ex
Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood.: Int Immunol. 1999 Apr;11(4):535-43. Unique Identifier : AIDSLINE MED/99254785; Wedderburn LR; Maini MK; Patel A; Beverley PC; Woo P; Department of Molecular Pathology, University College, London,; UK.; We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28- T cells. Sequencing of the TCRBV14 amplification products showed a TCR sequence which contributed 32% of the total TCR in the CD8+TCRBV14 p
An enlarged subpopulation of T lymphocytes bearing two distinct gammadelta TCR in an HIV-positive patient.: Int Immunol. 1999 Apr;11(4):545-52. Unique Identifier : AIDSLINE MED/99254786; Taupin JL; Halary F; Dechanet J; Peyrat MA; Ragnaud JM; Bonneville M; Moreau JF; CNRS UMR 5540, Universite de Bordeaux II, France.; Although T cell clone monospecificity is ensured by several allelic exclusion processes operating at either the genotypic or phenotypic levels, clones expressing two distinct alphabeta or gammadelta TCR have been described in several instances. Thus far, the origin of dual TCR-expressing cells and the homeostatic mech
Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis.: Int Immunol. 1999 Apr;11(4):553-9. Unique Identifier : AIDSLINE MED/99254787; Suzuki N; Nakajima A; Yoshino S; Matsushima K; Yagita H; Okumura K; Department of Joint Disease and Rheumatism, Nippon Medical; School, Tokyo, Japan.; Chemokines and their receptors play critical roles in the selective recruitment of various subsets of leukocytes. Recent studies have indicated that some chemokine receptors are differentially expressed on Th1 and Th2 cells. However, available data concerning the presence of T cells with a Th1 or a Th2 character and t
Differentiation of human single-positive fetal thymocytes in vitro into IL-4- and/or IFN-gamma-producing CD4+ and CD8+ T cells.: Int Immunol. 1999 Apr;11(4):593-603. Unique Identifier : AIDSLINE MED/99254792; Yamaguchi E; de Vries J; Yssel H; Department of Human Immunology, DNAX Research Institute, CA; 94304, USA.; In this study we have investigated the capacity of human fetal thymocytes to differentiate in vitro into subsets of T cells with polarized Th1 or Th2 cytokine profiles. Stimulation of freshly isolated human fetal thymocytes with anti-CD3 mAb, cross-linked onto CD32,CD58,CD80-expressing mouse fibroblasts and subsequent
Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations.: Int Immunol. 1999 Apr;11(4):617-21. Unique Identifier : AIDSLINE MED/99254794; Kelso A; Groves P; Ramm L; Doyle AG; Leukocyte Biology Unit, Queensland Institute of Medical Research,; Post Office Royal Brisbane Hospital, Australia.; RT-PCR was used to examine the expression of IFN-gamma, IL-2 , IL-4, IL-5, IL-6 and IL-10 mRNAs by single murine CD4+ T cells activated either in a strongly type 1-polarized mixed lymphocyte reaction (MLR) or in the type 2-polarized response to immunization with keyhole
Effect of scaffold attachment region on transgene expression in retrovirus vector-transduced primary T cells and macrophages.: Unique Identifier : AIDSLINE MED/99291790; Auten J; Agarwal M; Chen J; Sutton R; Plavec I; The scaffold attachment region of the human interferon beta gene (IFN-SAR) inserted into a retroviral vector improved transgene expression in human primary CD4+ and CD8+ T cells, and in primary monocytemacrophages. In T cells, expression of the Maloney murine leukemia virus (Mo-MuLV)-based retroviral vectors was high
A marker study of therapeutically transduced CD4+ peripheral blood lymphocytes in HIV discordant identical twins.: Hum Gene Ther. 1999 May 20;10(8):1401-21. Unique Identifier : AIDSLINE MED/99291791; Cooper D; Penny R; Symonds G; Carr A; Gerlach W; Sun LQ; Ely J; National Centre in HIV Epidemiology and Clinical Research,; Sydney, Australia.
Intrabodies to human immunodeficiency virus type 1 [comment]: Hum Gene Ther. 1999 Jun 10;10(9):1425-7. Unique Identifier : AIDSLINE MED/99321290; Paillard F
Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intrabodies [see comments]: Hum Gene Ther. 1999 Jun 10;10(9):1453-67. Unique Identifier : AIDSLINE MED/99321294; Mhashilkar AM; LaVecchio J; Eberhardt B; Porter-Brooks J; Boisot S; Dove JH; Pumphrey C; Li X; Weissmahr RN; Ring DB; Ramstedt U; Marasco WA; Department of Pathology, Dana-Farber Cancer Institute, Harvard; Medical School, Boston, MA 02115, USA.; We have previously reported that a murine anti-Tat sFv intrabody, termed sFvtat1Ck, directed against the proline-rich N-terminal activation domain of HIV-1, is a potent inhibitor of HIV-1 replication [Mhashilkar, A. M., et al. (1995). EMBO J. 14, 1542-1551]. In this study, the protective effect of sFvtat1Ck expression
Human cord blood CD34+CD38- cell transduction via lentivirus-based gene transfer vectors.: Hum Gene Ther. 1999 Jun 10;10(9):1479-89. Unique Identifier : AIDSLINE MED/99321296; Evans JT; Kelly PF; O'Neill E; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, TN 38105, USA.; The efficient transfer and sustained expression of a transgene in human hematopoietic cells with in vivo repopulating potential would provide a significant advancement in the development of protocols for the treatment of hematopoietic diseases. Recent advances in the ability to purify and culture hematopoietic cells w
Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis.: Hum Gene Ther. 1998 Dec 10;9(18):2717-26. Unique Identifier : AIDSLINE MED/99089666; Gallichan WS; Kafri T; Krahl T; Verma IM; Sarvetnick N; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.; Autoimmune destruction of islets in the pancreas leads to the development of insulin-dependent diabetes mellitus (IDDM). Replacement of insulin-producing tissue by transplantation of islets provides a cure to disease but requires immunosuppression or a means of controlling anti-graft immune responses. To promote islet
NKT cell cytokine imbalance in murine diabetes mellitus.: Autoimmunity. 1999;29(3):201-14. Unique Identifier : AIDSLINE MED/99360482; Frey AB; Rao TD; Department of Cell Biology, New York University Medical Center,; NY 10016, USA. freya01@popmail.med.nyu.edu; A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2
Function of rat pancreatic islets exposed to interleukin-18 in vitro.: Autoimmunity. 1999;29(4):263-7. Unique Identifier : AIDSLINE MED/99360463; Krook H; Wallstrom J; Sandler S; Department of Medical Cell Biology, Uppsala University, Sweden.; The recently cloned cytokine interleukin-18 (IL-18) has been shown to promote a Th1-cell immune response, which may be a prerequisite for development of Type 1 diabetes. In this study we examined the effects of IL-18 on the function of isolated rat pancreatic islets. The islets were cultured in medium RPMI 1640 + 10%
Polyamine-fas interactions: inhibition of polyamine biosynthesis in MRL-lpr/lpr mice is associated with the up-regulation of fas mRNA in thymocytes.: Autoimmunity. 1999;29(4):299-309. Unique Identifier : AIDSLINE MED/99360468; Hsu HC; Thomas T; Sigal LH; Thomas TJ; Department of Medicine, University of Medicine and Dentistry of; New Jersey-Robert Wood Johnson Medical School, New Brunswick; 08903, USA.; MRL-lpr/lpr is a strain of mice that develops spontaneous signs of the autoimmune disease, systemic lupus erythematosus (SLE or lupus). The lpr (lymphoproliferation) defect has been identified as an insertion of an early transposon (ETn) derived sequence into the fas apoptosis gene. We studied the in vivo effects of d
The traffic of resting lymphocytes through delayed hypersensitivity and chronic inflammatory lesions: a dynamic equilibrium.: Semin Immunol. 1999 Apr;11(2):115-23. Unique Identifier : AIDSLINE MED/99263410; Seabrook T; Au B; Dickstein J; Zhang X; Ristevski B; Hay JB; Department of Immunology, Faculty of Medicine, Medical Sciences; Building, University of Toronto, Toronto, ON, M5S 1A8, Canada.; This essay is designed as a partial summary of the work of several students and colleagues from our laboratory. For the most part the experimental data have been published and this seminar represents an attempt to summarize, integrate and speculate on this work. In some situations the speculation is rather unrestraine
The importance of lymphocyte trafficking in regulating blood lymphocyte levels during HIV and SIV infections.: Semin Immunol. 1999 Apr;11(2):139-54. Unique Identifier : AIDSLINE MED/99263412; Rosenberg YJ; Janossy G; The Immune Research Corporation Inc, 6701 Democracy Blvd. 201,; Suit 20189, Bethesda, MD 20817, USA.; In humans, blood is commonly monitored to provide surrogates of disease progression and assess immune status. However, the varied, rapid and atypical alterations in lymphocyte subsets which may occur in blood in response to pathogens, are not predictive of changes in the bulk of the immune system. A hallmark of human
Human T-cell lymphotropic virus type I and systemic lupus erythematosus [editorial; comment]: Intern Med. 1999 Jun;38(6):459-60. Unique Identifier : AIDSLINE MED/99337155; Ijichi S; Osame M
Human T cell leukemia virus type I-associated myelopathy in a patient with systemic lupus erythematosus [see comments]: Intern Med. 1999 Jun;38(6):512-5. Unique Identifier : AIDSLINE MED/99337167; Miura T; Tanaka H; Makino Y; Okamoto K; Iida T; Komura K; Fukawa E; Hirano F; Makino I; Second Department of Internal Medicine, Asahikawa Medical; College.; A case of human T cell leukemia virus type I (HTLV-1) associated myelopathy (HAM)/tropical spastic paraparesis (TSP) with 14-year history of systemic lupus erythematosus (SLE) is reported. For 9 years, the numbness of the feet and sacral region progressed with occasional urinary incontinence and constipation. She was
The Sixth John M. Kinney-Nestle Clinical Nutrition Award for Enteral Nutrition. Recombinant human tumor necrosis factor and recombinant murine interleukin-1 alter the binding of Escherichia coli to intestine, mucin glycoprotein, and the HT29-C1 intestinal cell line: a context [see comments]: Nutrition. 1999 Jun;15(6):427-9. Unique Identifier : AIDSLINE MED/99305955; Wanke CA; Tufts University School of Medicine, Boston, Massachusetts 02111,; USA. cwanke@infonet.tufts.edu
Body weight changes with protease inhibitor treatment in undernourished HIV-infected patients.: Nutrition. 1999 Jun;15(6):453-7. Unique Identifier : AIDSLINE MED/99305963; Schwenk A; Kremer G; Cornely O; Diehl V; Fatkenheuer G; Salzberger B; Department of Internal Medicine, University of Cologne, Germany.; a.schwenk@sghms.ac.uk; Effective reduction of HIV replication by protease inhibitor (PI) treatment was expected to reverse some of the weight loss associated with HIV infection. Body weight changes in undernourished HIV-infected patients starting PI treatment were compared to its virologic and immunologic effects. This was designed as a ret
Viral screening and assisted conception treatment--the Bourn Hall experience.: J Assist Reprod Genet. 1999 Jul;16(6):337-9. Unique Identifier : AIDSLINE MED/99322836; Abusheikha N; Akagbosu F; Marcus S; Lass A; Cousins C; Brinsden P; Assisted Conception Unit, Bourn Hall Clinic, Cambridge, UK.
Children with HIV: the challenge for general practice [editorial; comment]: BMJ. 1999 Jul 24;319(7204):207-8. Unique Identifier : AIDSLINE MED/99346029; Kidd M
General practice and the care of children with HIV infection: 6 month prospective interview study [see comments]: BMJ. 1999 Jul 24;319(7204):232-5. Unique Identifier : AIDSLINE MED/99346052; Boulton M; Beck E; Walters S; Miller D; Department of Epidemiology and Public Health, Imperial College; School of Medicine, London W2 1PG. m.boulton@ic.ac.uk; OBJECTIVES: To describe the use of primary care services by children infected with HIV and to explore the attitudes of their parents to the role of general practitioners in their children s care. DESIGN: A 6 month prospective study. Quantitative analysis of contact diaries kept by parents; qualitative analysis of fa
Expression of T cell activation antigen CD134 (OX40) has no predictive value for the occurrence or response to therapy of acute graft-versus-host disease in partial T cell-depleted bone marrow transplantation.: Bone Marrow Transplant. 1999 May;23(10):1013-7. Unique Identifier : AIDSLINE MED/99300282; Gadisseur AP; Gratama JW; Lamers C; van Esser JW; Bolhuis RL; Cornelissen JJ; Department of Hematology, Daniel den Hoed Cancer Center,; Rotterdam, The Netherlands.; CD134 (OX40) is a member of the tumor necrosis factor family which is expressed by activated T lymphocytes. CD134 expression on T cells was monitored during the first 35 days post-transplant in 14 patients, receiving either an HLA-identical sibling bone marrow transplant (BMT), a matched unrelated transplant (MUD-BMT)
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 Jul 30;9(31):277-80. Unique Identifier : AIDSLINE MED/99372007
Bilateral trochlear nerve palsy associated with cryptococcal meningitis in human immunodeficiency virus infection.: J Neuroophthalmol. 1999 Jun;19(2):118-9. Unique Identifier : AIDSLINE MED/99306799; Sadun F; De Negri AM; Santopadre P; Pivetti Pezzi P; Institute of Ophthalmology, University of Rome La Sapienza,; Italy.; This is the report of a case of bilateral trochlear nerve palsy secondary to cryptococcal meningitis in a 34-year-old woman with acquired immune deficiency syndrome. Based on clinical and neuroradiologic findings, it is concluded that in the present case, a postinflammatory shrinking of the arachnoid has stretched the
Wall-eyed bilateral internuclear ophthalmoplegia in central nervous system cryptococcosis.: J Neuroophthalmol. 1999 Jun;19(2):131-5. Unique Identifier : AIDSLINE MED/99306804; Fay PM; Strominger MB; Department of Ophthalmology, State University of New York Health; Science Center at Brooklyn, 11203, USA.; Only one case of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) has been described in central nervous system cryptococcosis. The disorder was initially unilateral, then became bilateral with skew deviation and vertical upgaze deficit. We report a case of WEBINO in central nervous system cryptococcosis in a
[Cost-benefit analysis of screening strategies by human immunodeficiency virus in French blood donors]: Unique Identifier : AIDSLINE MED/99351111; Djossou F; Salmi LR; Lawson-Ayayi S; Huet C; Perez P; Mathoulin-Pelissier S; Salamon R; BACKGROUND: The residual risk of human immunodeficiency virus (HIV) infection from screened blood transfusion was estimated to be 1.7/10(6) between 1993 and 1995 in France . To orient blood safety policies, we have evaluated what would be, from the perspective of blood banks, the be
Localization of HTLV-1 and HIV-1 proviral sequences in chromosomes of persistently infected cells.: Chromosome Res. 1999;7(3):177-83. Unique Identifier : AIDSLINE MED/99347745; Glukhova LA; Zoubak SV; Rynditch AV; Miller GG; Titova IV; Vorobyeva N; Lazurkevitch ZV; Graphodatskii AS; Kushch AA; Bernardi G; Ivanovsky Institute of Virology, Russian Academy of Medical; Sciences, Moscow.; Integration sites for HTLV-1 and HIV-1proviruses were detected by FISH on the chromosomes of HTHIV27 cells persistently infected by HIV-1 (strain IIIB). HTLV-1 signals were found on 9 loci of chromosomes 4, 6, 9, 15 and 16. Integration sites of GC-rich HTLV-1 provirus are located in GC-rich isochores, confirming an i
Noncytolytic HIV immunity.: Trends Microbiol. 1999 Apr;7(4):143. Unique Identifier : AIDSLINE MED/99235848; Slifka MK
HIV-1 attachment: another look.: Trends Microbiol. 1999 Apr;7(4):144-9. Unique Identifier : AIDSLINE MED/99235850; Ugolini S; Mondor I; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, 163 Avenue de Luminy,; Case 906, 13288 Marseille Cedex 9, France.; HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virio
HIV: a new role for Nef in the spread of HIV.: Curr Biol. 1999 Jun 17;9(12):R459-61. Unique Identifier : AIDSLINE MED/99307518; Harris M; Division of Microbiology, School of Biochemistry and Molecular; Biology,University of Leeds, Leeds LS2 9JT, UK.; mharris@bmb.leeds.ac.uk; The HIV Nef protein downregulates the cell-surface expression of the HIV receptor glycoprotein CD4, but the significance of this event has remained obscure. Recent data suggest that Nef reduces cell-surface CD4 to promote the efficient spread of the virus.
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.: Curr Biol. 1999 Jun 17;9(12):613-21. Unique Identifier : AIDSLINE MED/99307497; Ross TM; Oran AE; Cullen BR; Yerkes Regional Primate Research Center, Division of Microbiology; and Immunology, Emory University, Atlanta, Georgia 30329, USA.; BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) Nef protein is required for efficient virus replication in vivo and displays a number of distinct and apparently unrelated biological activities in vitro. Of these, one of the most readily demonstrated is the efficient internalization and degradation of cell-
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.: Curr Biol. 1999 Jun 17;9(12):622-31. Unique Identifier : AIDSLINE MED/99307498; Lama J; Mangasarian A; Trono D; La Jolla Institute for Allergy and Immunology Molecular; Immunology Division, 10355 Science Center Drive, San Diego,; California 92121, USA.; BACKGROUND: Human immunodeficiency virus-1 (HIV-1) infection decreases the cell-surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env and Vpu. Such functional convergence strongly suggests that CD4 downregulation is critical for optimal viral replication, yet the significance of th
Cognitive-behavioral group therapy with medication for depressed gay men with AIDS or symptomatic HIV infection.: Psychiatr Serv. 1999 Jul;50(7):948-52. Unique Identifier : AIDSLINE MED/99331029; Lee MR; Cohen L; Hadley SW; Goodwin FK; Clinical Studies, Ltd., Falls Church, VA, USA.; OBJECTIVE: The feasibility and effectiveness of a combination of group cognitive-behavioral therapy and medication for the treatment of depression among gay men with AIDS or symptomatic HIV infection were evaluated. METHODS: Fifteen patients diagnosed with DSM-IV major depressive disorder or dysthymia were treated in
Towards the structure of the human immunodeficiency virus: divide and conquer.: Curr Opin Struct Biol. 1999 Apr;9(2):231-43. Unique Identifier : AIDSLINE MED/99257338; Wilk T; Fuller SD; Structural Biology Programme, European Molecular Biology; Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany.; Recent publications have expanded our knowledge of the major structural proteins of the human immunodeficiency virus as isolated proteins. The next challenge lies in understanding the changes in structure and the interactions of these components during assembly and maturation.
Azodicarbonamide inhibits T-cell responses in vitro and in vivo.: Nat Med. 1999 Aug;5(8):947-50. Unique Identifier : AIDSLINE MED/99353364; Tassignon J; Ismaili J; Le Moine A; Van Laethem F; Leo O; Vandevelde M; Goldman M; Laboratory of Experimental Immunology, Universite Libre de; Bruxelles, Brussels, Belgium.; Azodicarbonamide was recently identified as a new anti-HIV agent that targets the zinc finger domains of the HIV-1 NCp7 nucleocapsid protein. Here, we demonstrate that azodicarbonamide inhibits in a dose-dependent manner the responses of purified human CD4+ T lymphocytes stimulated either by monoclonal antibodies agai
Blocking HIV-1 infection with intrakines [news]: Mol Med Today. 1999 Mar;5(3):97. Unique Identifier : AIDSLINE MED/99221891; Dorrell S
V3 loop-derived peptide SPC3 inhibits infection of CD4- and galactosylceramide- cells by LAV-2/B.: Unique Identifier : AIDSLINE MED/99334824; Moulard M; Mabrouk K; Martin I; Van Rietschoten J; Rochat H; Sabatier JM; Centre d'Immunologie de Marseille Luminy, France.; mmoulard@scripps.edu; SPC3, a synthetic multibranched peptide including the GPGRAF consensus motif of the human immunodeficiency virus type 1 (HIV-1) gp120 V3-loop is a potent inhibitor of HIV infection of human CD4+ lymphocytes, macrophages and CD4-/galactosylceramide+ human colon epithelial cells and is currently tested in phase II clini
Human monoclonal antibodies to MN-24 peptide of gp 120 HIV-1.: Hum Antibodies. 1999;9(2):107-10. Unique Identifier : AIDSLINE MED/99334303; Sidorova E; Institute for Viral Preparations of Russian Academy of Medical; Sciences, Moscow, Russia.; Human monoclonal IgM antibodies to synthetic peptide MN-24 corresponding to 303-325 residues of gp 120 HIV were obtained. Antibodies are made synthetic by CD5+B lymphocytes and are polyspecific: they react not only with different short peptides but with some macromolecular antigens as well. Anti-MN-24 antibodies posse
The significance of immune disorder in tropical spastic paraparesis.: Hum Antibodies. 1999;9(2):133-7. Unique Identifier : AIDSLINE MED/99334306; Smikle MF; Barton EN; Morgan OC; Luseko J; Bailey VE; Williams EM; Department of Medical Microbiology, University of the West Indies; Mona, Kingston, Jamaica.; The reports of the occurrence of HTLV-1 infection and/or HTLV-1 associated myelopathy (HAM/tropical spastic paraparesis (TSP) in patients with certain organ-specific and nonorgan-specific autoimmune diseases prompted us to assess the relationship between TSP and humoral autoimmunity. Blood samples from 76 TSP patients
Changing patterns of HIV related ocular disease.: Sex Transm Infect. 1999 Feb;75(1):18-20. Unique Identifier : AIDSLINE MED/99377445; Rauz S; Murray PI; Academic Unit of Ophthalmology, Birmingham and Midland Eye; Centre, City Hospital NHS Trust.; Cytomegalovirus ( CMV ) retinitis is the commonest ocular complication of AIDS and the prevention of recurrence has been dependent on lifelong maintenance treatment. Recently there has been a dramatic downturn in the number of new cases of CMV retinitis, which has
Acute pulmonary embolism in patients with HIV disease.: Sex Transm Infect. 1999 Feb;75(1):25-9. Unique Identifier : AIDSLINE MED/99377447; Howling SJ; Shaw PJ; Miller RF; Department of Imaging, University College London Hospitals Trust,; London.; OBJECTIVES: To determine the incidence, mode of presentation, and outcome of pulmonary embolism (PE) in patients with HIV infection. METHODS: Retrospective review of clinical case records, imaging department database, and necropsy reports of patients admitted to the specialist HIV/AIDS unit at UCL hospitals from April
From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection.: Sex Transm Infect. 1999 Feb;75(1):3-17. Unique Identifier : AIDSLINE MED/99377444; Fleming DT; Wasserheit JN; Division of STD Prevention, National Center for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; GA 30333, USA.; OBJECTIVES: To review the scientific data on the role of sexually transmitted diseases (STDs) in sexual transmission of HIV infection and discuss the implications of these findings for HIV and STD prevention policy and practice. METHODS: Articles were selected from a review of Medline, accessed with the OVID search en
HIV-1 and other sexually transmitted infections in a cohort of female sex workers in Chiang Rai, Thailand.: Sex Transm Infect. 1999 Feb;75(1):30-5. Unique Identifier : AIDSLINE MED/99377448; Limpakarnjanarat K; Mastro TD; Saisorn S; Uthaivoravit W; Kaewkungwal J; Korattana S; Young NL; Morse SA; Schmid DS; Weniger BG; Nieburg P; HIV/AIDS Collaboration, Ministry of Public Health, Nonthaburi,; Thailand.; OBJECTIVES: To determine demographic and behavioural factors and sexually transmitted infections (STIs) associated with prevalent HIV-1 infection among brothel based and other female sex workers (FSWs) in Chiang Rai, northern Thailand . METHODS: Data were collected from questionna
Evaluation of behavioural interventions in HIV/STI prevention.: Sex Transm Infect. 1999 Feb;75(1):69-71. Unique Identifier : AIDSLINE MED/99377458; Stephenson JM; Department of Sexually Transmitted Diseases, University College; London Medical School.; There is an urgent need for well designed randomised trials to assess the impact of behavioural interventions at both individual and community levels in developed and developing countries. The relative lack of such studies partly reflects the particular challenges of applying randomised trials in this area. Although t
Oral sex and the transmission of non-viral STIs [letter]: Sex Transm Infect. 1999 Feb;75(1):77. Unique Identifier : AIDSLINE MED/99377465; Stanley B
Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).: Sex Transm Infect. 1999 Apr;75(2):103-6. Unique Identifier : AIDSLINE MED/99377471; Leroy V; Ladner J; De Clercq A; Meheus A; Nyiraziraje M; Karita E; Dabis F; INSERM U 330, Universite Victor Segalen Bordeaux 2, France.; OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda . METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, H
Integrated clinical service for sexual assault victims in a genitourinary setting.: Sex Transm Infect. 1999 Apr;75(2):116-9. Unique Identifier : AIDSLINE MED/99377474; Bottomley CP; Sadler T; Welch J; Department of Sexual Health, King's College Hospital, London.; BACKGROUND: Reported sexual assault is increasing, and the diverse immediate and longer term needs of the victim are usually met by exposure to a number of healthcare professionals often in different locations, involving delays and travel, increasing the trauma for the victim. OBJECTIVES: To set up a centre to address
HIV testing and prevention: family planning clinic attenders in London [letter]: Sex Transm Infect. 1999 Apr;75(2):130. Unique Identifier : AIDSLINE MED/99377482; Bergenstrom A; Sherr L; Okolo S; Okolo S
HIV seroconversion illness following acute hepatitis A [letter]: Sex Transm Infect. 1999 Apr;75(2):133. Unique Identifier : AIDSLINE MED/99377491; Fox PA; Hawkins DA; Boag FC
From Mwanza and Rakai to Beijing and Moscow? STD control and HIV prevention [editorial]: Sex Transm Infect. 1999 Apr;75(2):83-5. Unique Identifier : AIDSLINE MED/99377466; Grosskurth H
Is nucleoside analogue monotherapy sufficient for treatment of HBV infection? Lessons from HIV [editorial]: Sex Transm Infect. 1999 Apr;75(2):87-8. Unique Identifier : AIDSLINE MED/99377468; Pillay D; Cane PA; Mutimer D
British HIV Association guidelines for prescribing antiretroviral therapy in pregnancy (1998).: Sex Transm Infect. 1999 Apr;75(2):90-7. Unique Identifier : AIDSLINE MED/99377469; Taylor GP; Lyall EG; Mercey D; Smith R; Chester T; Newell ML; Tudor-Williams G; Department of GU Medicine and Communicable Diseases, Imperial; College School of Medicine, St Mary's Hospital, London.; The aim of antiretroviral therapy in pregnancy is to deliver a healthy uninfected child to a healthy mother, without prejudicing the future treatment opportunities of the mother. The use of zidovudine monotherapy rapidly became standard practice once it had been shown to reduce by 67% mother to child transmission in w
Seroprevalence and incidence of genital ulcer infections in a rural Ugandan population [see comments]: Sex Transm Infect. 1999 Apr;75(2):98-102. Unique Identifier : AIDSLINE MED/99377470; Kamali A; Nunn AJ; Mulder DW; Van Dyck E; Dobbins JG; Whitworth JA; Medical Research Council Programme on AIDS in Uganda/Uganda Virus; Research Institute, Entebbe, Uganda.; OBJECTIVES: To determine age-sex specific seroprevalence and incidence rates of Treponema pallidum, Haemophilus ducreyi, and HSV-2; to assess the association between HIV-1 status and incidence of these STIs; and HSV-2 serostatus with number of lifetime sexual partners. METHODS: Antibodies against HIV-1, T pallidum, H
The use of HIV resistance assays--random or randomised? [editorial]: Sex Transm Infect. 1999 Jun;75(3):140-1. Unique Identifier : AIDSLINE MED/99377494; Loveday C; Dunn D; McCormack S; Babiker A
Commentary: resistance testing--a clinical perspective.: Sex Transm Infect. 1999 Jun;75(3):141-2. Unique Identifier : AIDSLINE MED/99377495; Gazzard BG; Moyle G; Chelsea and Westminster Hospital, London.
The role of chemokine receptors in HIV infection.: Sex Transm Infect. 1999 Jun;75(3):148-51. Unique Identifier : AIDSLINE MED/99377499; Rowland-Jones S; Human Immunology Unit, John Radcliffe Hospital, Headington,; Oxford.
A study of anal intraepithelial neoplasia in HIV positive homosexual men.: Sex Transm Infect. 1999 Jun;75(3):172-7. Unique Identifier : AIDSLINE MED/99377504; Lacey HB; Wilson GE; Tilston P; Wilkins EG; Bailey AS; Corbitt G; Green PM; Department of Genito-Urinary Medicine, North Manchester Health; Care Trust.; OBJECTIVES: To determine the prevalence of high grade anal intraepithelial neoplasia (HGAIN), the value of anal cytology in screening for HGAIN, and the characterisation of epidemiological factors and human papillomavirus (HPV) types. METHODS: Prospective cohort study of HIV positive homosexual men. Subjects were inte
Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro.: Unique Identifier : AIDSLINE MED/99377506; Thormar H; Bergsson G; Gunnarsson E; Georgsson G; Witvrouw M; Steingrimsson O; De Clercq E; Kristmundsdottir T; OBJECTIVE: To investigate the in vitro microbicidal and cytocidal potency of monocaprin dissolved in pharmaceutical hydrogel formulations and to evaluate their potential use as vaginal microbicides against sexually transmitted pathogens such as herpes simplex virus type 2 (HSV-2), human immunodeficiency virus type 1 (
HIV infection and sexually transmitted diseases in a referral STD centre in south India.: Sex Transm Infect. 1999 Jun;75(3):191. Unique Identifier : AIDSLINE MED/99377510; Thappa DM; Singh S; Singh A; Department of Dermatology and STD, Jawaharlal Institute of; Postgraduate Medical Education and Research, Pondicherry, India.
Protection from Pneumocystis carinii pneumonia [letter]: Sex Transm Infect. 1999 Jun;75(3):202-3. Unique Identifier : AIDSLINE MED/99377516; Day JH; Williams IG; Zumla A; Miller RF
Screening for sexually transmitted disease and HIV infection in termination of pregnancy services: a survey in South Thames region [letter]: Sex Transm Infect. 1999 Jun;75(3):203. Unique Identifier : AIDSLINE MED/99377517; Harper R; Maguire H; Kurtz Z; Hamilton G; Bradbeer C; Bootes J
Local treatment of a chronic leg ulcer with GM-CSF in a patient with HIV infection [letter]: Sex Transm Infect. 1999 Jun;75(3):203-4. Unique Identifier : AIDSLINE MED/99377518; Mastroianni A; Cancellieri C
Positive attitude towards antiretroviral therapy after 6 months of treatment in a sample of Dutch HIV infected people [letter]: Sex Transm Infect. 1999 Jun;75(3):204. Unique Identifier : AIDSLINE MED/99377519; Reedijk M; Bindels PJ; Wigersma L
Influenza myositis and rhabdomyolysis in an HIV positive man: was zidovudine a co-factor? [letter]: Sex Transm Infect. 1999 Jun;75(3):204-5. Unique Identifier : AIDSLINE MED/99377521; Guha I; Brook MG
Specific high-performance liquid chromatography assay for determination of rifabutin plasma concentration following Extrelut column extraction.: J Chromatogr B Biomed Sci Appl. 1999 May 28;728(2):233-9. Unique Identifier : AIDSLINE MED/99332841; Gatti G; De Pascalis CR; Miletich F; Casazza R; Bassetti D; 1st Department of Infectious Diseases, University of Genova,; Ospedale San Martino, Italy.; A specific, precise and accurate assay for determination of rifabutin in human plasma using Extrelut column extraction was developed and validated. Rifabutin concentrations were calculated with a standard curve ranging from 5 to 800 ng ml(-1). using a split-curve approach. Chromatographic peaks were separated by means
Evaluation of BC-3 and BCP-1 cell lines in immunofluorescence assay to detect HHV-8 antibodies in Kaposi's sarcoma, multiple myeloma and other groups.: J Clin Virol. 1999 May;12(3):221-31. Unique Identifier : AIDSLINE MED/99310192; Couty JP; Ranger-Rogez S; Venot C; Jaccard A; Rogez JP; Weinbreck P; Bordessoule D; Denis F; Department of Microbiology, EP CNRS 118, Limoges, France.; j.couty@lemel.fr; BACKGROUND: We describe a comparative study of an immunofluorescence assay using inducible BC-3 and BCP-1 cell lines as sources of HHV-8 antigens. STUDY DESIGN: Detection of both antibodies to proteins expressed in lytic cycle and during latency in sera from HIV-infected patients with KS, HIV-positive patients without
The Health Belief Model and HIV risk behaviours: a causal model analysis among Anglos, African-Americans and Mexican-Americans.: Ethn Health. 1998 Nov;3(4):283-99. Unique Identifier : AIDSLINE MED/99331542; Neff JA; Crawford SL; University of Tennessee College of Social Work-Nashville Branch,; USA.; A causal model of the Health Belief Model (HBM) is empirically evaluated which emphasizes possible indirect paths linking distal demographic and seriousness/susceptibility variables to HIV risk behaviours among Anglo, African-American, and Mexican-American adults. A specific focus of the paper is upon alcohol-related
Urinary tract infections in HIV disease.: Int J Antimicrob Agents. 1999 May;11(3-4):309-11. Unique Identifier : AIDSLINE MED/99320912; Schonwald S; Begovac J; Skerk V; University Hospital for Infectious Diseases, Zagreb, Croatia.; HIV-positive patients are liable to acquire opportunistic infections. Their liability to acquire other common infectious conditions is less frequently reported. In order to determine the frequency of urinary tract infections (UTI) in HIV-positive patients, we performed a retrospective analysis. The control group was f
Modulation of cytokine responses of murine CD8+ alphabeta intestinal intraepithelial lymphocytes by IL-4 and IL-12.: J Biomed Sci. 1999 Jul-Aug;6(4):269-76. Unique Identifier : AIDSLINE MED/99350676; Gelfanova V; Lai Y; Gelfanov V; Tzou S; Tu Y; Liao N; Institute of Molecular Biology, Academia Sinica, National Taiwan; University, Taiwan, ROC.; The immune responses of the intestine mucosa feature the noninflammatory type, such as IgA production and oral tolerance. Th2 type cytokines have been implicated in the induction of these noninflammatory responses. In the present study, cytokine responses of CD8+ and CD4+ TCRalphabeta+ intestinal intraepithelial lymph
Synthesis of the tBuSATE pronucleotide of AZT by two different synthetic approaches.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1001-2. Unique Identifier : AIDSLINE MED/99361294; Lannuzel M; Egron D; Imbach JL; Gosselin G; Perigaud C; Laboratoire de Chimie Bioorganique, U.M.R. 5625; C.N.R.S.-U.S.T.L., Universite de Montpellier II, France.; A large scale synthesis of the tBuSATE pronucleotide of AZT was required for in vivo studies. A comparative synthesis of this derivative by phosphoramidite and monophosphate approaches is reported.
Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1005-6. Unique Identifier : AIDSLINE MED/99361296; Loi AG; Faraj A; Pierra C; Gosselin G; Imbach JL; Locarnini SA; Groman EV; Schinazi RF; Sommadossi JP; Department of Pharmacology, Univ. of Alabama at Birmingham, USA.; We have investigated the effects of several beta-D-ddA 5 -monophospate (beta-D-ddAMP), and their corresponding beta-L-enantiomers prodrugs against HBV replication. All ddAMP prodrugs inhibited HBV replication in a dose-dependent manner.
Synthesis of AZT-alpha-Borano-5'-diphospho-hexoses.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1023-4. Unique Identifier : AIDSLINE MED/99361299; Sarfati S; Guerreiro C; Canard B; Dereuddre-Bosquet N; Clayette P; Dormont D; Unite de Chimie Organique, Institut Pasteur, Paris, France.; 3 -Azido-3 -deoxythymidine-alpha-borano-5 -diphospho-hexoses have been synthesized. Their diastereoisomers were separated by HPLC.
New series of mixed pronucleotides. Synthesis and anti-HIV activities of mononucleoside phenyl SATE phosphotriesters.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1025-6. Unique Identifier : AIDSLINE MED/99361300; Schlienger N; Peyrottes S; Aubertin AM; Gosselin G; Imbach JL; Perigaud C; Laboratoire de Chimie Bioorganique, U.M.R. CNRS 5625, Universite; Montpellier II, France.; The synthesis and anti-HIV activities of phenyl S-pivaloyl-2-thioethyl (tBuSATE) phosphotriesters of AZT and d4T are reported. These compounds show similar activity compared to bis(tB
Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1029-30. Unique Identifier : AIDSLINE MED/99361302; Velazquez S; Tunon V; Jimeno ML; Perez-Perez MJ; San-Felix A; Chamorro C; Lobaton E; Esteban-Gamboa A; De Clercq E; Balzarini J; Camarasa MJ; Instituto de Quimica Medica (C.S.I.C.), Madrid, Spain.; Novel series of [ddN]-(CH2)n-[TSAO-T] heterodimers have been prepared and tested for their anti-HIV-1 and HIV-2 activity. The most active compound of this series was the [ d4T ]-(CH2)3-[TSAO-T] heterodimer (EC50 = 0.018 +/- 0.03 microM).
Human DNA polymerases and retroviral reverse transcriptases: selectivity in respect to dNTPs modified at triphosphate residues.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1031-2. Unique Identifier : AIDSLINE MED/99361303; Victorova LS; Semizarov DG; Shirokova EA; Alexandrova LA; Arzumanov AA; Jasko MV; Krayevsky AA; Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia.
Bicyclonucleosides and ring-chain interconversion.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1077-8. Unique Identifier : AIDSLINE MED/99361307; Tronchet JM; Zsely M; Brenas L; Lassout O; Grand E; Seuret P; Grigorov M; Rivara-Minten E; Geoffroy M; University of Geneva, Department of Pharmaceutical Chemistry,; Switzerland.; Four types of bicyclonucleosides differing in the easiness of their ring-chain interconversion have been prepared, some exhibited anti-HIV activity and the ratio of their cyclic and open-chain forms could have some bearing on their biological activity.
New classes of fluorinated L-nucleosides; synthesis and antiviral activity.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):537-40. Unique Identifier : AIDSLINE MED/99361209; Lee K; Choi Y; Hong JH; Schinazi RF; Chu CK; Department of Parmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens 30602, USA.; The synthesis of 3 -fluorinated apionucleosides 7 and 2 -fluoro-2 ,3 -unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2 -F-d4C, L-2 -F-d4FC and L-2 -F-d4A exhibit significant anti-HIV and anti-HBV activities.
Synthesis and testing of new modified nucleosides.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):541-6. Unique Identifier : AIDSLINE MED/99361210; Jung ME; Nichols CJ; Kretschik O; Xu Y; Department of Chemistry and Biochemistry, University of; California, Los Angeles 90095-1569, USA.; New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2 ,3 -dideoxy isonucleosides 2abc (both the oxa and thia analogues) as well as new route
Simple and stereoselective syntheses of nucleoside analogues with a benzo[c]furan glycone moiety.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):559-63. Unique Identifier : AIDSLINE MED/99361211; Ewing DF; Fahmi N; Mackenzie G; Pranzo A; Department of Chemistry, University of Hull, UK.; A series of d4T analogues have been synthesised in which the 2 ,3 -didehydro-2 ,3 -dideoxyribose moiety is replaced by a benzo[c]furan core. A simple strategy has been developed to access a range of compounds for biological screening. In addition, a s
Synthesis and antiviral activity of L-2'-deoxy-2'-up-fluoro-4'-thionucleosides.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):571-2. Unique Identifier : AIDSLINE MED/99361213; Jeong LS; Moon HR; Yoo SJ; Lee SN; Kim HD; Chun MW; College of Pharmacy, Ewha Womans University, Seoul, Korea.; L-2 -Deoxy-2 -up-fluoro-4 -thionucleosides were efficiently synthesized from D-xylose via L-4-thioarabitol derivative as a key intermediate and evaluated for antiviral activities against HIV-1, HSV-1,2 and HBV.
Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):615-6. Unique Identifier : AIDSLINE MED/99361219; Chun MW; Choi SP; Kim MJ; Bae CJ; Moon HR; Kim HD; Jeong LS; College of Pharmacy, Seoul National University, Korea.; Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from D-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV.
3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):633-4. Unique Identifier : AIDSLINE MED/99361220; Fedorov I; Kazmina E; Jasko M; Balzarini J; De Clercq E; Sommadossi JP; Imbach JL; Gosselin G; Moscow Medical Sechenov Academy, Russia.; A series of 3 -(N-hydroxyimino)-2 ,3 -dideoxynucleosides bearing different nucleic bases has been prepared. In vitro antiviral activity studies showed that among these compounds the thymine derivative possesses significant activity against HIV, HSV, EBV and HBV. Conveniently 5 -protected 3 -(N-hydroxyimino)-2 ,3 -dide
Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):643-4. Unique Identifier : AIDSLINE MED/99361222; Pierra C; Gosselin G; Sommadossi JP; Faraj A; De Clercq E; Balzarini J; Imbach JL; Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite de; Montpellier II, France.; Several 5-chlorouracil and 5-chlorocytosine beta-L-dideoxynucleosides were stereospecifically synthesized and their activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) were examined in cell culture.
Synthesis and antiviral activity of D- and L-isodideoxy nucleosides with exocyclic-methylene.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):655-6. Unique Identifier : AIDSLINE MED/99361225; Jeong LS; Yoo SJ; Moon HR; Chun MW; Lee CK; Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha; Womans University, Seoul, Korea.; Novel D- and L-isodideoxynucleosides were synthesized starting from D- and L-xylose and evaluated for antiviral activities against HIV-1, HSV-1, HSV-2, HBV and HCMV, respectively.
Synthesis of nucleosides having unusual branched sugars as potential antiviral agents.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):657-8. Unique Identifier : AIDSLINE MED/99361226; Kato K; Yamamura S; Research Laboratories, Nippon Kayaku Co. Ltd., Tokyo, Japan.; Enantiomerically pure novel nucleosides having unusual branched sugars were synthesized in a stereospecific manner from a common chiral pool of (S, S)-1,4-bis(benzyloxy)-2,3-epoxybutane and evaluated for antiviral activity.
Potential inhibitors of HIV integrase.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):681-2. Unique Identifier : AIDSLINE MED/99361229; Mathe C; Nair V; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.; In the search for inhibitors of HIV integrase, the enzyme involved in the integration of viral DNA into host DNA, we have synthesized and studied a number of analogs of the heterocyclic molecule, chloroquine.
"Mixed inhibitors" of HIV-reverse transcriptase: synthesis and antiviral activity.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):707-8. Unique Identifier : AIDSLINE MED/99361234; Pontikis R; Note R; Dechaux E; Guillaumel J; Aubertin AM; Grierson DS; Monneret C; Institut Curie, Section Recherche, UMR-176 CNRS-IC, Paris,; France.; Some AZT-HEPT and ddC-HEPT conjugates were designed, synthesized and evaluated for their anti-HIV activity.
Synthesis of some fully 3' and 4'-C-branched-chain sugar nucleoside analogues.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):731-2. Unique Identifier : AIDSLINE MED/99361238; Ton-That T; CNRS-UM II 5625, Laboratoire de Chimie Bioorganique, Universite; Montpellier II, France.; The synthesis of some new 3 -azido-3 -C-substituted pyrimidine nucleoside analogues is described. The key step is the geminal disubstitution of an appropriated ketone carbohydrate, via the regioselective ring opening of the corresponding tosyl-epoxide derivative.
Synthesis of a nucleoside bioconjugate system as a potential anti-HIV agent.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):737-8. Unique Identifier : AIDSLINE MED/99361240; Van Calenbergh S; Nair V; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.; Synthesis and anti-HIV data for a bioconjugate molecule incorporating a HIV protease inhibitor (A74704) and a HIV RT inhibitor ( d4T ) are presented.
Resistance profiles of (+)2'-deoxy-3'-oxa-4'-thiocytidine and (-)2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):773-8. Unique Identifier : AIDSLINE MED/99361244; Richard N; Salomon H; Oliveira M; Rando R; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.; Resistant variants were selected in vitro against two novel nucleoside analogues, (+) dOTC and (-) dOTFC using the HIV-1 molecular clone HXB2D. The variants obtained displayed 6.5-fold and 10-fold resistance to these compounds, respectively. Cloning and sequencing of the RT genes of the selected viruses identified two
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):795-805. Unique Identifier : AIDSLINE MED/99361246; Maga G; Amacker M; Hubscher U; Gosselin G; Imbach JL; Mathe C; Faraj A; Sommadossi JP; Spadari S; Istituto di Genetica Biochimica el Evoluzionistica, Consiglio; Nazionale delle Ricerche, Pavia, Italy.; We have compared the HIV-1 RT mutants containing the single substitutions L100I, K103N, V106A, V179D, Y181I and Y188L, known to confer NNI-resistance in treated patients, to HIV-1 RT wt for their sensitivity towards inhibition by D- and L-deoxy- and dideoxy-nucleoside tiphosphates. The results showed a differential ef
Phosphorylation of anti-HIV nucleoside analogs by nucleoside diphosphate kinase.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):829-30. Unique Identifier : AIDSLINE MED/99361251; Schneider B; Xu Y; Sellam O; Sarfati R; Janin J; Veron M; Deville-Bonne D; Unite de Regulation Enzymatique des Activites Cellulaires,; CNRS URA1773, Institut Pasteur, Paris, France.; The reaction of NDP kinase with antiviral nucleoside triphosphates used in antiviral therapies was studied at the presteady state by fluorescence stopped-flow and compared with the steady-state parameters. The affinity of the analogs was determined by fluorescence titration of a mutated enzyme with an inserted Trp in
Mechanism of inhibition of HIV reverse transcriptase by 1-(2-deoxy-beta-D-ribofuranosyl)-4-acetylimidazolin-2-one (imidine).: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):847-8. Unique Identifier : AIDSLINE MED/99361256; Kalman TI; Sen K; Jiang XJ; State University at New York, Department of Medicinal Chemistry,; Buffalo 14260, USA.
Effect of acyclic nucleoside phosphonates on the HIV-1 integrase in vitro.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):849-51. Unique Identifier : AIDSLINE MED/99361257; Abu Sheika G; Tramontano E; Loi AG; Franchetti P; Grifantini M; La Colla P; Dipartimento di Biologia Sperimentale, Universita di Cagliari,; Italy.; Integrase (IN) is an essential enzyme in the human immunodeficiency virus type-1 (HIV-1) replication cycle and, thus, a potential target for chemotherapeutic agents. Because various nucleotide analogues have been reported to inhibit IN in vitro, we investigated the effect of acyclic nucleoside phosphonates. Both unpho
Synthesis and biological evaluation of polyaminated 2',3'-dideoxy-3'-thiacytidine prodrugs.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):879-80. Unique Identifier : AIDSLINE MED/99361265; Camplo M; Mourier N; Chermann JC; Kraus JL; Laboratoire de Chimie Biomoleculaire, INSERM U 322, Universite; de la Mediterrannee, Faculte des Sciences de Luminy,; Marseille, France.; The syntheses and biological evaluation of polyaminated 2 ,3 -dideoxy-3 -thiacytidine have been performed. A new lead was found to increase the in vitro antiviral potency (syncitia formation on MT-4 cell line) of two order magnitude greater than the parent nucleoside drug. Moreover, the in vitro activity on HIV macrop
New polyazamacrocycle-nucleoside conjugates: synthesis, anti-HIV evaluation and interaction with CXCR-4 coreceptor.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):881-2. Unique Identifier : AIDSLINE MED/99361266; Dessolin J; Galea P; Vlieghe P; Chermann JC; Kraus JL; Laboratoire de Chimie Biomoleculaire, Faculte des Sciences de; Luminy, Universite de la Mediterranee, Marseille, France.; We report the synthesis of new conjugates that incorporate in their structure bis-tetraazamacrocycle coupled with AZT via enzymolabile bond. Two series of bis-polyazamacrocycles-AZT conjugates were designed, synthesized and evaluated for their antivir
Synthesis of novel C-5 substituted d4T analogues bearing linker arms as potential anti-HIV agents.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):883-4. Unique Identifier : AIDSLINE MED/99361267; Laduree D; Fossey C; Renoud-Grappin M; Fontaine G; Camara F; Gavriliu D; Ciurea A; Aubertin AM; Kirn A; C.E.R.M.N., Laboratoire de Pharmacochimie, Caen France.; This work reports the synthesis of 2 ,3 -didehydro-2 ,3 -dideoxy-thymidine analogues bearing several kinds of amino-linker arms at the C-5 position of the pyrimidine moiety. C-5 is an attractive position since a flexible chain may permit the triphosphates to be generated. The beta-D- and beta-L-
Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):891-2. Unique Identifier : AIDSLINE MED/99361269; Gu Z; Wainberg MA; Nguyen-Ba P; L'Heureux L; de Muys JM; Rando RF; BioChem Therapeutics Inc., Laval, Quebec, Canada.; DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC50s for DXG were 0.032 microM in CBMCs and 0.05 microM in MT-4 cells, which were generally equipotent as 3TC . 3TC-resistant, but not AZT-resist
Quantification of lamivudine (3TC) by competitive immunoassay.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):893-6. Unique Identifier : AIDSLINE MED/99361270; Akeb F; Creminon C; Nevers MC; Grassi J; Duval D; Guedj R; Laboratoire de Chimie Bio-Organique, ESA CNRS 6001, Faculte des; Sciences, Universite de Nice-Sophia Antipolis, Nice, France.; Lamivudine or 3TC , the (-) eniantiomer of 2 -deoxy-3 -thiacytidine, is a prototype of a novel class of levogyre dideoxynucleosides analogues used in treatment of HIV and HBV infection
Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):897-8. Unique Identifier : AIDSLINE MED/99361271; Bergman AM; Cristalli G; Vittori S; Wang J; Eriksson S; Peters GJ; Dept. Oncology, University Hospital VU, Amsterdam, The; Netherlands.; Several 1-deazapurine nucleosides were tested for their biological activity, anti-HIV-1, cytotoxicity and inhibition of adenosine deaminase (ADA). A2780 human ovarian cancer cells and the deoxycytidine kinase (dCK) deficient variant AG6000, used to determine whether dCK plays a role in their activation, showed a simil
Antiviral activity and resistance profile of phosphazid--a novel prodrug of AZT.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):901-6. Unique Identifier : AIDSLINE MED/99361272; Machado J; Salomon H; Oliveira M; Tsoukas C; Krayevsky AA; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.; Both AZT and its novel 5 -hydrogen phosphonate derivative, Phosphazid, possess similar in vitro activity and resistance profiles. Experiments involving AZT-resistant virus isolates revealed a strong correlation between resistance to AZT and cross-resi
Antiviral nucleoside drug delivery via amino acid phosphoramidates.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):913-9. Unique Identifier : AIDSLINE MED/99361274; Wagner CR; Chang SL; Griesgraber GW; Song H; McIntee EJ; Zimmerman CL; Department of Medicinal Chemistry, University of Minnesota,; Minneapolis 55455, USA.; Stable and water soluble amino acid phosphomonoester amidates of AZT were synthesized and shown to have potent anti-HIV-1 activity. Intracellular and cell extract metabolism studies revealed that these compounds are likely to be enzymatically converte
ddC- and 3TC-bis(SATE) monophosphate prodrugs overcome cellular resistance mechanisms to HIV-1 associated with cytidine kinase deficiency.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):921-6. Unique Identifier : AIDSLINE MED/99361275; Groschel B; Himmel N; Cinatl J; Perigaud C; Gosselin G; Imbach JL; Doerr HW; Cinatl J Jr; Institute of Medical Virology, Johann Wolfgang Goethe University; Frankfurt/M., Germany.; A 2 ,3 -dideoxycytidine ( ddC )-resistant T-lymphoid cell line (MOLT-4/8rddC250), in which deoxycytidine kinase (dCK) gene-expression was decreased when compared with parental cells, has been selected. Cytotoxic and antiretroviral activity of ddC and
Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):933-6. Unique Identifier : AIDSLINE MED/99361277; Groschel B; Meier C; Zehner R; Cinatl J; Doerr HW; Cinatl J Jr; Institute of Medical Virology, Johann Wolfgang Goethe University,; Frankfurt/M., Germany.; Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.
Synthesis of analogues of 5'-mono-, 5'-di-, and 5'-triphosphate-AZT for the development of specific enzyme immunoassay for monitoring of intracellular levels of AZT-MP, AZT-DP, and AZT-TP.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):939-40. Unique Identifier : AIDSLINE MED/99361278; Brossette T; Nevers MC; Creminon C; Mioskowski C; Grassi J; Lebeau L; Laboratoire de Synthese Bioorganique associe au CNRS,; Universite Louis Pasteur, Faculte de pharmacie, Illkirch,; France.; The synthesis of analogue compounds of polyphosphorylated AZT is described. The compounds are designed to raise specific antibodies against AZT-MP, -DP and -TP in rabbits.
A new cyclic phosphoramidate D4T prodrug approach cycloAmb-D4T-phosphoramidates.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):947-8. Unique Identifier : AIDSLINE MED/99361281; Lorey M; Meier C; Institut fur Organische Chemie, Universitat Hamburg, Germany.; A new potential phosphoramidate prodrug approach for d4T 1 is described. In hydrolyses studies the cycloAmb-d4T-phosphoramidates 2 and 3 proved to deliver d4TMP following a tandem reaction.
Synthesis, in vitro anti-HIV and anti-hepatitis B activities and pharmacokinetic properties of amphiphilic heterodinucleoside phosphates containing ddC and AZT.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):949-50. Unique Identifier : AIDSLINE MED/99361282; Schwendener RA; Peghini PA; Ludwing PS; Schott H; Dept. of Pathology, University Hospital, Zurich, Germany.; Amphiphilic heterodinucleoside phosphates containing AZT and ddC as antiviral monomer were synthesized according to the hydrogenphosphonate method and evaluated in vitro against HIV.
An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):967-9. Unique Identifier : AIDSLINE MED/99361286; Ballatore C; McGuigan C; De Clercq E; Balzarini J; Welsh School of Pharmacy, Cardiff University, UK.; The pig liver esterase (PLE) assay has been designed to reproduce in vitro the first step of the metabolism of phosphoramidate pro-drugs that generates the free amino acyl phosphoramidate intermediate which has been described as a key metabolite necessary but not sufficient for the biological activity. The method co
Anti-HIV pronucleotides: SATE versus phenyl as a protecting group of AZT phosphoramidate derivatives.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):973-5. Unique Identifier : AIDSLINE MED/99361288; Beltran T; Egron D; Lefebvre I; Perigaud C; Pompon A; Gosselin G; Aubertin AM; Imbach JL; Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625,; Universite Montpellier II, France.; We comparatively studied the decomposition pathways in CEM cell extract of several PHENYL phosphoramidate diesters of AZT . A correlation between anti-HIV activities in TK- cell lines and pharmacokinetic data has been observed. This study would help to
Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3'-azido-2',3'-dideoxythymidine.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):981-2. Unique Identifier : AIDSLINE MED/99361289; Egron D; Perigaud C; Gosselin G; Aubertin AM; Imbach JL; Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625,; Universite Montpellier II, France.; The synthesis and in vitro anti-HIV activity of tBuSATE phosphoramidate derivatives of AZT incorporating several methyl-esterified alpha-amino acids are reported. The biological evaluation strongly supports the hypothesis that such compounds exert the
Synthesis, anti-HIV activity and stability studies of 3'-azido-2',3'-dideoxythymidine 5'-fluorophosphate.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):983-4. Unique Identifier : AIDSLINE MED/99361290; Egron D; Arzumanov AA; Dyatkina NB; Krayevsky A; Imbach JL; Aubertin AM; Gosselin G; Perigaud C; Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625,; Universite Montpellier II, France.; The synthesis, in vitro anti-HIV activity, and stability studies of AZT 5 -fluorophosphate (F-AZTMP) are reported. The present results demonstrate that such compound is a bioprecursor of its parent 5 -mononucleotide (AZTMP) but its biotransformation d
Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):989-90. Unique Identifier : AIDSLINE MED/99361292; Franchetti P; Abu Sheikha G; Cappellacci L; Grifantini M; Balestra E; Perno CF; Brandi G; Rossi L; Magnani M; Dipartimento di Scienze Chimiche, Universita di Camerino, Italy.; A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in
Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT.: Nucleosides Nucleotides. 1999 Apr-May;18(4-5):993-4. Unique Identifier : AIDSLINE MED/99361293; Kers I; Girardet JL; Gosselin G; Perigaud C; Imbach JL; Stawinski J; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm; University, Sweden.; The synthesis of some symmetrical phosphoramidate dimers of AZT is presented. The synthetic scheme includes the formation of the symmetrical H-phosphonate diester of AZT, followed by its conversion to several dinucleoside phosphoramidate analogues. Th
T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (review).: Int J Mol Med. 1999 Jul;4(1):91-7. Unique Identifier : AIDSLINE MED/99303956; Fleury S; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Department of Medicine,; Division of Infectious Diseases, CH-1011 Lausanne, Switzerland.; The initial idea that high amounts of cytopathic virus produced everyday can drive high CD4+ T cell production seemed logical and explained the progressive CD4+ T cell depletion observed in HIV-infected subjects. It was hypothesized that the CD4+ T lymphocyte production was increased up to 70-fold in HIV-infected subj
Effect of beta-chemokines on human immunodeficiency virus type 1 replication, binding, uncoating, and CCR5 receptor expression in human monocyte-derived macrophages.: J Hum Virol. 1999 May-Jun;2(3):123-32. Unique Identifier : AIDSLINE MED/99339708; Jiang Y; Jolly PE; School of Public Health, University of Alabama at Birmingham,; 35294-0022, USA.; OBJECTIVES: We examined the effect and time of addition of beta-chemokines on human immunodeficiency virus type 1 (HIV-1) replication, binding, and uncoating in human macrophages and measured CCR5 receptor expression during virus binding and uncoating. METHODS: Macrophages were treated with beta-chemokines before infe
In vitro phenotype of SDF1 gene mutant that delays the onset of human immunodeficiency virus disease in vivo.: J Hum Virol. 1999 May-Jun;2(3):133-8. Unique Identifier : AIDSLINE MED/99339709; Arya SK; Ginsberg CC; Davis-Warren A; D'Costa J; Basic Research Laboratory, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; aryas@dc37a.nci.nih.gov; OBJECTIVE: Inheritance of a mutant allele of the SDF1 gene delays the onset of human immunodeficiency virus type 1 (HIV-1) disease. Because the mutation lies in the 3 untranslated region of the gene, it was suggested that this mutation may upregulate transcription of the gene, resulting in more abundant SDF1, which i
Increased expression of nitric oxide synthase and dendritic injury in simian immunodeficiency virus encephalitis.: J Hum Virol. 1999 May-Jun;2(3):139-45. Unique Identifier : AIDSLINE MED/99339710; Li Q; Eiden LE; Cavert W; Reinhart TA; Rausch DM; Murray EA; Weihe E; Haase AT; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA.; OBJECTIVES: Widespread dendritic injury may be one mechanism involved in the neurologic impairment that occurs in HIV-1 infection. The objectives of this study were to quantitate the extent of dendritic injury in a primate model of central nervous system (CNS) infection, investigate the role of nitric oxide (NO) as a
Identification of insertion mutations in HIV-1 reverse transcriptase causing multiple drug resistance to nucleoside analogue reverse transcriptase inhibitors.: J Hum Virol. 1999 May-Jun;2(3):146-53. Unique Identifier : AIDSLINE MED/99339711; Sugiura W; Matsuda M; Matsuda Z; Abumi H; Okano A; Oishi T; Moriya K; Yamamoto Y; Fukutake K; Mimaya J; Ajisawa A; Taki M; Yamada K; Nagai Y; National institute of Infectious Diseases AIDS Research Center,; Tokyo, Japan. wsugiura@nih.go.jp; OBJECTIVE: A novel 2-amino acid insertion between codons 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) which confers multiple drug resistance has recently been reported. Independently, we have identified similar insertion mutations in Japanese hemophiliacs and attempted to analyze
Analysis of HIV-1 in the cervicovaginal secretions and blood of pregnant and nonpregnant women.: J Hum Virol. 1999 May-Jun;2(3):154-66. Unique Identifier : AIDSLINE MED/99339712; Shaheen F; Sison AV; McIntosh L; Mukhtar M; Pomerantz RJ; The Dorrance H. Hamilton Laboratories, Center for Human Virology,; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.; OBJECTIVES: To detect HIV-1 in cellular and acellular fractions of cervicovaginal secretions obtained by cervicovaginal lavage (CVL) and evaluate viral genotypes in the HIV-1-positive CVL samples. STUDY DESIGN/METHODS: This study consists of 37 HIV-1-seropositive pregnant and nonpregnant women from the
Transactivation is a conserved function among primate lentivirus Vpr proteins but is not shared by Vpx.: J Hum Virol. 1999 May-Jun;2(3):167-74. Unique Identifier : AIDSLINE MED/99339713; Philippon V; Matsuda Z; Essex M; Department of Immunology and Infectious Diseases, Harvard AIDS; Institute, Harvard School of Public Health, Boston, Massachusetts; 02115-6017, USA.; OBJECTIVE: To investigate the transactivating activity of Vpr proteins from human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency viruses (SIVs) on various primate lentivirus long terminal repeats (LTRs), and to determine whether the Vpx proteins shared by HIV-2 and SIV are able to
Proceedings of the Second National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S1-86. Unique Identifier : AIDSLINE MED/99357279
Effect of antiretroviral therapy on recent trends in selected cancers among HIV-infected persons. Adult/Adolescent Spectrum of HIV Disease Project Group.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S11-7. Unique Identifier : AIDSLINE MED/99357281; Jones JL; Hanson DL; Dworkin MS; Ward JW; Jaffe HW; Division of HIV/AIDS Prevention--Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; jlj1@cdc.gov; We examined incidence trends in seven HIV-associated cancers (Kaposi s sarcoma [KS], invasive cervical cancer, immunoblastic lymphoma, primary brain lymphoma [PBL], Burkitt s lymphoma, other non-Hodgkin s lymphomas, and Hodgkin s lymphoma) and the effects of antiretroviral therapy on these trends. Data were abstracted
Effect of highly active antiretroviral therapy on the incidence of HIV-associated malignancies at an urban medical center.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S18-22. Unique Identifier : AIDSLINE MED/99357282; Sparano JA; Anand K; Desai J; Mitnick RJ; Kalkut GE; Hanau LH; Department of Oncology, The Albert Einstein Comprehensive Cancer; Center, Montefiore Medical Center, Bronx, New York 10461, USA.; The widespread use of highly active antiretroviral therapy (HAART) since 1996 has led to a substantial decline in morbidity and mortality in patients infected with HIV, although its effect on the incidence of HIV-associated malignancies is unknown. We retrospectively reviewed the annual number of outpatient visits to
Combination antiretroviral therapy and incidence of AIDS-related malignancies.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S23-6. Unique Identifier : AIDSLINE MED/99357283; Buchbinder SP; Holmberg SD; Scheer S; Colfax G; O'Malley P; Vittinghoff E; HIV Research Section, San Francisco Department of Public Health,; California, USA.; We evaluated recent trends in the incidence of AIDS-related malignancies using Cox proportional hazards analysis in 622 men with well-characterized dates of HIV seroconversion in the San Francisco City Clinic cohort. By the end of 1996, 182 men had been diagnosed with Kaposi s sarcoma (KS), and 45 men had been diagnos
AIDS-associated non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S27-30. Unique Identifier : AIDSLINE MED/99357284; Grulich AE; National Centre in HIV Epidemiology and Clinical Research,; Sydney, New South Wales, Australia. agrulich@nchecr.unsw.edu.au; In populations receiving highly active antiretroviral therapy (HAART), the incidence of non-Hodgkin s lymphoma (NHL) has decreased by less than other AIDS-associated illnesses. In Australian AIDS-registration data, NHL has decreased by 37.5% since 1994, compared with a 55% decrease
Kaposi's sarcoma and non-Hodgkin's lymphoma incidence trends in AIDS Clinical Trial Group study participants.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S31-3. Unique Identifier : AIDSLINE MED/99357285; Rabkin CS; Testa MA; Huang J; Von Roenn JH; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland, USA.; Combination therapy with protease inhibitors and nucleoside analogues dramatically suppresses plasma HIV-1 RNA and delays progression to AIDS, but the impact on HIV-associated malignancy remains to be established. We therefore examined incidence trends of Kaposi s s
Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S34-41. Unique Identifier : AIDSLINE MED/99357286; Jacobson LP; Yamashita TE; Detels R; Margolick JB; Chmiel JS; Kingsley LA; Melnick S; Munoz A; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA. ljacobso@jhsph.edu; Effective HIV-1 therapies may directly or indirectly impact the development of AIDS-associated malignancies. Using data from the Multicenter AIDS Cohort Study, a longitudinal cohort study of the natural history of HIV-1 infection among homosexual men, the incidence rates of Kaposi s sarcoma (KS) and
Anal squamous intraepithelial lesions: relation to HIV and human papillomavirus infection.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S42-8. Unique Identifier : AIDSLINE MED/99357287; Palefsky JM; Department of Laboratory Medicine, University of California-San; Francisco, 94143, USA.; Studies from the era prior to the introduction of highly active antiretroviral therapy (HAART) have shown that the prevalence of anal infection with human papillomavirus (HPV) and anal squamous intraepithelial lesions (ASIL) were high among HIV-positive homosexual men, and to a lesser extent, among HIV-negative homose
Role of human papillomaviruses in cutaneous and oral manifestations of immunosuppression.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S49-57. Unique Identifier : AIDSLINE MED/99357288; Leigh IM; Buchanan JA; Harwood CA; Cerio R; Storey A; Imperial Cancer Research Fund Skin Tumour Laboratory, Clinical; Sciences Research Centre, St. Bartholomew's and Royal London; School of Medicine and Dentistry, UK.; Long-term immunosuppressive drug regimes, used to prevent organ transplant rejection, are associated with an increased risk of epithelial malignancies particularly anogenital and cutaneous cancers. Premalignant and malignant lesions of the oral mucosa have also been reported in renal transplant recipients (RTRs), part
Overview of the epidemiology of malignancy in immune deficiency.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S5-10. Unique Identifier : AIDSLINE MED/99357280; Mueller N; Harvard School of Public Health, Boston, Massachusetts 02115,; USA.; Immune-suppressed populations experience higher rates of cancer than expected. The most common malignancies are non-Hodgkin s lymphoma (NHL) in those with HIV infection, in organ transplant recipients, and in those with primary immune deficiencies; Kaposi s sarcoma (KS) in those wi
Consideration of host-viral interactions in the pathogenesis of Kaposi's sarcoma.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S58-65. Unique Identifier : AIDSLINE MED/99357289; Offermann MK; Winship Cancer Center, Department of Medicine, Emory University,; Atlanta, Georgia 30322, USA. mofferm@emory.edu; Human herpesvirus type 8 (HHV-8) is a recently identified gamma herpesvirus that is associated with and most likely the etiologic agent of Kaposi s sarcoma (KS). Both monocytes and B lymphocytes appear to serve as reservoirs for HHV-8 in asymptomatic individuals, whereas HHV-8 is present in both spindle cells and micr
Therapy for Kaposi's sarcoma: recent advances and experimental approaches.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S66-73. Unique Identifier : AIDSLINE MED/99357290; Yarchoan R; HIV and AIDS Malignancy Branch, Division of Clinical Sciences,; National Cancer Institute, Bethesda, Maryland 20892-1906, USA.; yarchoan@helix.nih.gov; The past several years have seen demonstrable progress in the therapy of Kaposi s sarcoma (KS). Liposomal anthracyclines and paclitaxel have been found to be highly effective chemotherapeutic agents for this disease. Recent advances in our understanding of the pathogenesis of KS have led to the consideration of variou
Identifying the precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: role of the germinal center in B-cell lymphomagenesis.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S74-9. Unique Identifier : AIDSLINE MED/99357291; Kuppers R; Institute for Genetics, University of Cologne, Germany.; rkuppers@mac.genetik.uni-koeln.de; In the course of T-cell-dependent immune responses, germinal centers (GCs) are established within secondary lymphoid organs. In these structures, B lymphocytes clonally expand and modify their immunoglobulin (Ig) V genes by somatic hypermutation. In a process called affinity maturation, GC B cells expressing antigen r
Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S80-3. Unique Identifier : AIDSLINE MED/99357292; Moss DJ; Khanna R; Sherritt M; Elliott SL; Burrows SR; Epstein-Barr Virus Unit, University of Queensland and the; Queensland Institute of Medical Research, Brisbane, Australia.; denisM@qimr.edu.au; Epstein-Barr virus (EBV) infection is associated with various physical human malignancies. The potential for immunotherapeutic treatment by cytotoxic T cells (CTL) depends on the degree of EBV-antigen expression, with the best prospect revolving around the immunoblastic lymphomas of organ transplant patients in which
An HIV community perspective on AIDS malignancy basic and clinical research.: J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S84-6. Unique Identifier : AIDSLINE MED/99357293; Marco M; Clinical Science, Treatment Action Group, New York, New York; 10023, USA.
Susceptibility genes for AIDS and AIDS-related lymphoma.: Curr Top Microbiol Immunol. 1999;246:111-4; discussion 115. Unique Identifier : AIDSLINE MED/99324368; Rabkin CS; Sei S; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; MD 20892, USA.
Molecular mechanisms of T helper cell differentiation and tissue-specific migration.: Curr Top Microbiol Immunol. 1999;246:117-22. Unique Identifier : AIDSLINE MED/99324369; D'Ambrosio D; Panina-Bordignon P; Rogge L; Sinigaglia F; Roche Milano Ricerche