1999

Synthesis and HIV-1 inhibitory properties of new tetrahydrobenzoquinazolinedione and tetrahydrobenzocycloheptenuracil derivatives and of their thioxo analogues.: Unique Identifier : AIDSLINE MED/99312712; Macchia M; Antonelli G; Balsamo A
Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles.: Farmaco. 1999 Apr 30;54(4):255-64. Unique Identifier : AIDSLINE MED/99312714; Merino I; Monge A; Font M; Martinez de Irujo JJ; Alberdi E; Santiago E; Prieto I; Lasarte JJ; Sarobe P; Borras F; Departamento Quimica Organica y Farmaceutica, Universidad de; Navarra, Pamplona, Spain.; A set of new pyrimido[5,4-b]indole derivatives that are structurally related to some non-nucleside HIV-1 reverse transcriptase inhibitors were synthesized and biologically evaluated for their activity as inhibitors of wild and mutant HIV-1 RT types in an in vitro recombinant HIV-1 RT screening assay, as well as anti
Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia.: Am J Reprod Immunol. 1999 May;41(5):297-306. Unique Identifier : AIDSLINE MED/99305787; Saito S; Umekage H; Sakamoto Y; Sakai M; Tanebe K; Sasaki Y; Morikawa H; Department of Obstetrics and Gynecology, Toyama Medical and; Pharmaceutical University, Japan.; PROBLEM: To examine whether preeclampsia involves type-1 T-helper (TH1) immune hyperactivity. METHOD OF STUDY: Expression of HLA-DR, a cell-surface marker of activation, was analyzed on CD3+, CD4+, and CD8+ T cells in 15 preeclamptic patients and 15 normal pregnant women using flow cytometry. Additionally, peripheral
Vertical transmission of HIV: parameters which might affect infection of placental trophoblasts by HIV-1: a review. Biomed Group on the Study of in Utero Transmission of HIV 1.: Am J Reprod Immunol. 1999 May;41(5):312-9. Unique Identifier : AIDSLINE MED/99305789; Moussa M; Mognetti B; Dubanchet S; Menu E; Roques P; Gras G; Dormont D; Barre-Sinoussi F; Chaouat G; INSERM U 131, Cytokines et Immunoregulation, Hopital Antoine; Beclere, Clamart, France.; PROBLEM: To understand the mechanisms preventing and/or facilitating maternofetal transmission of human immunodeficiency virus (HIV)-1 across the placenta during pregnancy. METHODS OF STUDY: Current experimental data were reviewed. RESULTS AND CONCLUSIONS: The data about the production of cytokines by placental cells
Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids.: Biochemistry. 1999 Jul 6;38(27):8808-19. Unique Identifier : AIDSLINE MED/99321518; Short GF 3rd; Golovine SY; Hecht SM; Departments of Chemistry and Biology, University of Virginia,; Charlottesville, Virginia 22901, USA.; An in vitro protein synthesizing system was modified to facilitate the improved, site-specific incorporation of unnatural amino acids into proteins via readthrough of mRNA nonsense (UAG) codons by chemically misacylated suppressor tRNAs. The modified system included an S-30 extract derived from Escherichia coli that e
Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat.: Biochemistry. 1999 Jul 6;38(27):8826-30. Unique Identifier : AIDSLINE MED/99321520; Creaven M; Hans F; Mutskov V; Col E; Caron C; Dimitrov S; Khochbin S; Equipe de Chromatine et Expression des Genes, Equipe; d'Assemblage et Regulation de l'Appareil Genetique,; Laboratoire de Biologie Moleculaire et Cellulaire de la; Differenciation, INSERM U309, France.; Tip60, a cellular histone-acetyltransferase, is known to interact with the HIV-1-encoded transactivator protein, Tat. In this work, we show that the interaction of Tat with Tip60 efficiently inhibits the Tip60 histone-acetyltransferase activity. Besides its histone-acetyltransferase activity, Tip60 can undergo an auto
The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.: Biochemistry. 1999 Jul 13;38(28):8892-8. Unique Identifier : AIDSLINE PDB/1B92; Greenwald J; Le V; Butler SL; Bushman FD; Choe S; Structural Biology Laboratory, The Salk Institute, La Jolla,; California 92037, USA.; Replication of HIV-1 requires the covalent integration of the viral cDNA into the host chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the importance of a protein surface loop near the integrase active site using protein engineering and X-ray crystallography. We have redetermined the s
A care package for managing female sexual assault in genitourinary medicine.: Int J STD AIDS. 1999 May;10(5):283-9. Unique Identifier : AIDSLINE MED/99288761; Harrison JM; Murphy SM; Department of Genitourinary Medicine and Clinical Health; Psychology, St Mary's Hospital, London, UK.; This paper describes the development of a designated in-house service for the management of adult female victims of sexual assault within the Department of Genitourinary Medicine (GUM) at St Mary s Hospital, London. This was set up in 1994 as a need was identified by medical, nursing, psychological and health advising
Neisseria gonorrhoeae in Newcastle upon Tyne 1995-1997: increase in ciprofloxacin resistance.: Int J STD AIDS. 1999 May;10(5):290-3. Unique Identifier : AIDSLINE MED/99288762; Tayal SC; Sankar KN; Pattman RS; Watson PG; Galloway A; Department of Genito-Urinary Medicine, Newcastle General; Hospital, Newcastle upon Tyne, UK. STayal8144@aol.com; Fluoroquinolones and third generation cephalosporins are the most effective antimicrobial agents for the treatment of gonorrhoea. However, clinically significant resistance to fluoroquinolones in Neisseria gonorrhoeae has been reported worldwide including Britain. The aim of this analysis was to study the factors rela
Trends in HIV-related consultation in Dutch general practice.: Int J STD AIDS. 1999 May;10(5):294-9. Unique Identifier : AIDSLINE MED/99288763; Ros CC; Kerssens JJ; Foets M; Peters L; NIVEL (Netherlands Institute of Primary Health Care), Utrecht.; c.ros@nivel.nl; New medicine against AIDS and a possible changing attitude towards AIDS will affect the role of the general practitioner (GP). We aim to explore and assess the changing role of the GP in preventing and detecting AIDS, which will be done by providing insight into the changing numbers and content of HIV-related consulta
Seroprevalence of HIV, HBV, and syphilis and associated risk behaviours in male transvestites (Hijras) in Karachi, Pakistan.: Int J STD AIDS. 1999 May;10(5):300-4. Unique Identifier : AIDSLINE MED/99288764; Baqi S; Shah SA; Baig MA; Mujeeb SA; Memon A; Department of Medicine, Ziauddin University Hospital, Clifton,; Karachi, Pakistan.; In Pakistan , male sex workers are predominantly transvestites and transsexuals known as Hijras. In 1998 in Karachi, Pakistan, we studied the seroprevalence of HIV, HBsAg and syphilis and associated risk factors in Hijras. Study subjects were verbally administered a structured que
Bacterial vaginosis in lesbians: evidence for lack of sexual transmission.: Int J STD AIDS. 1999 May;10(5):305-8. Unique Identifier : AIDSLINE MED/99288765; McCaffrey M; Varney P; Evans B; Taylor-Robinson D; Department of Genitourinary Medicine, Imperial College School of; Medicine at St Mary's, Paddington, London, UK.; The effect of non-heterosexual factors on the vaginal flora has been studied. Ninety-one lesbians attending a specialist genitourinary medicine service for lesbians were studied. Bacterial vaginosis (BV) was diagnosed in 51.6% of them. While most of the women had previously had a male sexual partner, the presence of B
Treatment delay and reliance on private physicians among patients with sexually transmitted diseases in China.: Int J STD AIDS. 1999 May;10(5):309-15. Unique Identifier : AIDSLINE MED/99288766; Choi KH; Zheng X; Zhou H; Chen W; Mandel J; University of California-San Francisco, Center for AIDS; Prevention Studies, 94105, USA.; We examined health-care seeking practices among patients with sexually transmitted diseases (STDs) in south China . In 1995, we recruited a consecutive sample of 939 STD patients attending the STD clinics of the Municipal STD Control Centers of Guangzhou and Shenzhen, special econom
An epidemiological evaluation of the use of microbiological tools for identifying gonorrhoea infection networks.: Int J STD AIDS. 1999 May;10(5):316-23. Unique Identifier : AIDSLINE MED/99288767; Pierce RL; Thomas JC; Sparling PF; Fisher W; Davis RH; Alcorn T; Cohen M; Department of Epidemiology, School of Public Health, University; of North Carolina, Chapel Hill 27599-7400, USA.; We aimed to assess the utility of various techniques for identifying gonorrhoea infection networks. All residents of a non-metropolitan North Carolina county visiting a sexually transmitted disease (STD) clinic during a 17-month period were screened for gonorrhoea. Infection networks were estimated by serovar type com
Inadequate treatment for sexually transmitted diseases in the South African private health sector.: Unique Identifier : AIDSLINE MED/99288768; Connolly AM; Wilkinson D; Harrison A; Lurie M; Karim SS; Correct management of sexually transmitted diseases (STDs) is important for their control, and to reduce HIV transmission. Guidelines on syndromic management of STDs were introduced by the provincial Department of Health in KwaZulu/Natal (KZN) in South Africa in 1995. The drug tre
Routine reporting or sentinel surveys for HIV/AIDS surveillance in resource-poor settings: experience in South Africa, 1991-97.: Int J STD AIDS. 1999 May;10(5):328-30. Unique Identifier : AIDSLINE MED/99288769; Stuart JM; Irlam JH; Wilkinson D; KwaZulu Department of Health AIDS Programme, Amatikulu Centre,; Nyoni, South Africa.; Information from routine and sentinel surveillance was used to monitor the HIV/AIDS epidemic in KwaZulu-Natal, South Africa between 1991 and 1997. Comparisons were made between data obtained from (1) sentinel surveillance for antenatal HIV infection, pulmonary tuberculosis (PTB),
Chlamydia trachomatis infection in women with and without cervical intraepithelial neoplasia.: Int J STD AIDS. 1999 May;10(5):331-3. Unique Identifier : AIDSLINE MED/99288770; Takac I; Gorisek B; Gynecology and Perinatology Clinic, Maribor Teaching Hospital,; Slovenia. iztok.takac@sb-mb.si; The aim of the study was to compare the frequency of Chlamydia trachomatis infection in patients with cervical intraepithelial neoplasia (CIN) and in women without cervical pathology. In a study group of 423 patients with histologically proven CIN and in 108 controls with normal cervical smear, cytological material fo
A case of cat scratch disease masquerading as lymphogranuloma venereum.: Int J STD AIDS. 1999 May;10(5):334-5. Unique Identifier : AIDSLINE MED/99288771; Hagley M; Carne CA; Gorgees N; Clinic 1A, Addenbrooke's Hospital, Cambridge, UK.
Simultaneous occurrence of HTLV-I associated myelopathy, uveitis and smouldering adult T cell leukaemia. GIPH (Interdisciplinary HTLV-I/II Research Group).: Int J STD AIDS. 1999 May;10(5):336-7. Unique Identifier : AIDSLINE MED/99288772; Goncalves DU; Guedes AC; Carneiro-Proietti AB; Pinheiro SR; Catalan-Soares B; Proietti FA; Lambertucci JR; Department of Internal Medicine, Universidade Federal de Minas; Gerais, Brazil.
HIV/AIDS in Bangladesh: an assessment of biomedical risk factors for transmission.: Int J STD AIDS. 1999 May;10(5):338-46. Unique Identifier : AIDSLINE MED/99288773; Gibney L; Choudhury P; Khawaja Z; Sarker M; Islam N; Vermund SH; Schools of Public Health and Medicine, University of Alabama at; Birmingham, 35294-0022, USA. lgibney@uab.edu; Behavioural risk factors for HIV/AIDS in Bangladesh were reviewed in a preceding article in this journal. Omitted from that review was a discussion of potential biomedical risk factors including: (i) an unregulated blood supply system in which blood used in transfusions is not
Prevention of pelvic infection: room for improvement [letter]: Int J STD AIDS. 1999 May;10(5):351. Unique Identifier : AIDSLINE MED/99288774; Skinner CJ; Estcourt CS; Grant L; Forster GE
Outcome of inflammatory smears managed in a genitourinary medicine clinic [letter]: Int J STD AIDS. 1999 May;10(5):351-2. Unique Identifier : AIDSLINE MED/99288775; Harry TC
A self-consistent, microenvironment modulated screened coulomb potential approximation to calculate pH-dependent electrostatic effects in proteins.: Biophys J. 1999 Jul;77(1):3-22. Unique Identifier : AIDSLINE MED/99318716; Mehler EL; Guarnieri F; Department of Physiology and Biophysics, Mount Sinai School of; Medicine, CUNY, New York, New York 10029, USA.; mehler@inka.mssm.edu; An improved approach is presented for calculating pH-dependent electrostatic effects in proteins using sigmoidally screened Coulomb potentials (SCP). It is hypothesized that a key determinant of seemingly aberrant behavior in pKa shifts is due to the properties of the unique microenvironment around each residue. To he
HLA-derived peptides as novel immunomodulatory therapeutics.: J Am Soc Nephrol. 1999 Jun;10(6):1346-55. Unique Identifier : AIDSLINE MED/99288721; Murphy B; Krensky AM; Department of Medicine, Mount Sinai School of Medicine, New York,; New York, USA.; A growing body of experimental evidence demonstrates that synthetic peptides corresponding to linear sequences of MHC (HLA in humans) proteins have immunomodulatory effects in vitro and in vivo in animal models and in humans. Although the original concept was that these peptides inhibited antigen recognition at the MH
Rational optimization of a HIV-1 Tat inhibitor: rapid progress on combinatorial lead structures.: Biotechnol Bioeng. 1998-99;61(3):155-68. Unique Identifier : AIDSLINE MED/99328735; Klimkait T; Felder ER; Albrecht G; Hamy F; Institute for Medical Microbiology, University of Basel, Basel,; Switzerland.; Lead molecules identified by combinatorial chemistry approaches are preferred starting points for straightforward improvements of compound profiles. Structure-guided rationales can be supported and complemented by systematic variations based on the modular nature of the molecules. A peptoidic compound (CGP 64222), pre
The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.: Blood. 1999 Jul 15;94(2):663-72. Unique Identifier : AIDSLINE MED/99326318; Barillari G; Sgadari C; Fiorelli V; Samaniego F; Colombini S; Manzari V; Modesti A; Nair BC; Cafaro A; Sturzl M; Ensoli B; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi s sarcoma (KS) development in infected individuals. In this study, we investigated the molecular mechanisms responsible for the angiogenic effec
The relationship of personality dimensions in adult male rhesus macaques to progression of simian immunodeficiency virus disease.: Brain Behav Immun. 1999 Jun;13(2):138-54. Unique Identifier : AIDSLINE MED/99303528; Capitanio JP; Mendoza SP; Baroncelli S; California Regional Primate Research Center, University of; California, Davis, California 95616, USA.; Studies of nonhuman primate personality have suggested that physiological correlates of relevant behavioral dimensions exist. The present study examined personality using techniques similar to those employed in human personality research. Adult male rhesus monkeys were each rated on 25 adjectives while living in their
Differential immune system changes with acute and persistent stress for optimists vs pessimists.: Brain Behav Immun. 1999 Jun;13(2):155-74. Unique Identifier : AIDSLINE MED/99303529; Cohen F; Kearney KA; Zegans LS; Kemeny ME; Neuhaus JM; Stites DP; Department of Psychiatry, University of California, San; Francisco, USA.; This study investigated whether acute and persistent stressors and life change events were followed by changes in immune status, and whether dispositional optimism moderated these relationships. Thirty-nine healthy women ages 18-45 were followed prospectively for 3 months, with weekly assessment of acute and persisten
[Epidemiology of non-Hodgkin's lymphoma: recent data]: Bull Cancer. 1999 Jun;86(6):529-36. Unique Identifier : AIDSLINE MED/99348133; Chassagne-Clement C; Blay JY; Treilleux I; Sebban C; Bergeron C; Biron P; Philip T; Centre Leon-Berard, 28, rue Laennec, 69008 Lyon.; Non-Hodgkin s lymphoma consists of a group of disorders which is increasing for the last decades. In the USA, since the early 1970s, the incidence rate has increased by almost 60% and ranges from 3 to 4% per year, which is faster than for the majority of cancers. Important advances in our knowledge of histopathology t
Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy.: Int Arch Allergy Immunol. 1999 Jun;119(2):86-94. Unique Identifier : AIDSLINE MED/99323826; Haas H; Falcone FH; Holland MJ; Schramm G; Haisch K; Gibbs BF; Bufe A; Schlaak M; Forschungszentrum Borstel, Germany. hhaas@fz-borstel.de; The etiology of IgE-mediated allergies is complex and, thus far, not completely understood. A common feature, however, is the overproduction of IgE-inducing cytokines, e.g. interleukin-4(IL-4), compared to IgE-antagonistic cytokines, such as interferon-gamma or IL-12. IgE-inducing cytokines are produced by T helper ty
Doctors demand AIDS drugs for women who have been raped [news]: BMJ. 1999 Jun 5;318(7197):1507. Unique Identifier : AIDSLINE MED/99284564; Sidley P
Authors' words foster stigmatisation of commercial sex workers in India [letter; comment]: BMJ. 1999 Jun 5;318(7197):1559. Unique Identifier : AIDSLINE MED/99284605; Patnaik P; Gupta R; Lambert H
Prevention of vertical transmission of HIV: analysis of cost effectiveness of options available in South Africa.: BMJ. 1999 Jun 19;318(7199):1650-6. Unique Identifier : AIDSLINE MED/99301831; Soderlund N; Zwi K; Kinghorn A; Gray G; Centre for Health Policy, University of the Witwatersrand PO Box; 1038, Johannesburg 2000, South Africa. soderlun@icon.co.za; OBJECTIVE: To assess the cost effectiveness of vertical transmission prevention strategies by using a mathematical simulation model. DESIGN: A Markov chain model was used to simulate the cost effectiveness of four formula feeding strategies, three antiretroviral interventions, and combined formula feeding and antiretr
Universal HIV screening of pregnant women in England: cost effectiveness analysis.: BMJ. 1999 Jun 19;318(7199):1656-60. Unique Identifier : AIDSLINE MED/99301832; Postma MJ; Beck EJ; Mandalia S; Sherr L; Walters MD; Houweling H; Jager JC; National Institute of Public Health and the Environment, PO Box; 3720 BA Bilthoven, The Netherlands.; OBJECTIVE: To estimate the cost effectiveness of universal, voluntary HIV screening of pregnant women in England. DESIGN: Cost effectiveness analysis. Cost estimates of caring for HIV positive children were based on the stage of HIV infection and calculated using data obtained from a London hospital between 1986 and 1
Antenatal HIV testing: assessment of a routine voluntary approach.: BMJ. 1999 Jun 19;318(7199):1660-1. Unique Identifier : AIDSLINE MED/99301833; Simpson WM; Johnstone FD; Goldberg DJ; Gormley SM; Hart GJ; Department of Obstetrics and Gynaecology, Centre for Reproductive; Biology, University of Edinburgh, EH3 9EW.; wendy@lumsdenpark.freeserve.co.uk
Comparison of enzymatic activities of the HIV-1 and HFV integrases to their U5 LTR substrates.: Biochem Mol Biol Int. 1999 Apr;47(4):621-9. Unique Identifier : AIDSLINE MED/99252972; Oh YT; Shin CG; Department of Biotechnology, Chung-Ang University, Kyungki,; Korea.; The human immunodeficiency virus type 1 (HIV-1) and human foamy virus (HFV) integrase proteins were overexpressed in Escherichia coli, and purified to a near homogeneity by one- or two-step purification scheme. The endonucleolytic, integration, and disintegration activities for the HIV-1 and HFV integrases were charac
Multifactorial analysis of exchanger efficiency and liquid conservation during perfluorochemical liquid-assisted ventilation.: Biomed Instrum Technol. 1999 May-Jun;33(3):260-7. Unique Identifier : AIDSLINE MED/99288488; Wolfson MR; Miller TF; Peck G; Shaffer TH; Department of Physiology, Temple University School of Medicine,; Philadelphia, Pennsylvania 19140, USA.; marlar@astro.ocis.temple.edu; Liquid-assisted ventilation (LAV) of the lung with perfluorochemical (PFC) requires a method of oxygenating and removing CO2 from the liquid. Current PFC LAV techniques consist of total liquid ventilation, PFC lavage, and partial liquid ventilation. Because PFC liquid is volatile, it may be lost from the lung or venti
The paramyxovirus fusion protein forms an extremely stable core trimer: structural parallels to influenza virus haemagglutinin and HIV-1 gp41.: Mol Membr Biol. 1999 Jan-Mar;16(1):11-9. Unique Identifier : AIDSLINE MED/99265137; Lamb RA; Joshi SB; Dutch RE; Howard Hughes Medical Institute, Northwestern University,; Evanston, IL 60208-3500, USA.; The paramyxovirus fusion (F) protein mediates membrane fusion. The biologically active F protein consists of a membrane distal subunit F2 and a membrane anchored subunit F1. A highly stable structure has been identified comprised of peptides derived from the simian virus 5 (SV5) F1 heptad repeat A, which abuts the hyd
Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells.: Mol Membr Biol. 1999 Jan-Mar;16(1):111-8. Unique Identifier : AIDSLINE MED/99265149; Duzgunes N; Pretzer E; Simoes S; Slepushkin V; Konopka K; Flasher D; de Lima MC; Department of Microbiology, School of Dentistry, University of; the Pacific, San Francisco, CA 94115, USA. nduzgune@uop.edu; Intracellular delivery of novel macromolecular drugs against human immunodeficiency virus type-1 (HIV-1), including antisense oligodeoxynucleotides, ribozymes and therapeutic genes, may be achieved by encapsulation in or association with certain types of liposomes. Liposomes may also protect these drugs against nuclea
Structural basis for membrane fusion by enveloped viruses.: Mol Membr Biol. 1999 Jan-Mar;16(1):3-9. Unique Identifier : AIDSLINE MED/99265136; Weissenhorn W; Dessen A; Calder LJ; Harrison SC; Skehel JJ; Wiley DC; Laboratory of Molecular Medicine, Children's Hospital, Boston, MA; 02215, USA. weissen@embl-grenoble.fr; Enveloped viruses such as HIV-1, influenza virus, and Ebola virus express a surface glycoprotein that mediates both cell attachment and fusion of viral and cellular membranes. The membrane fusion process leads to the release of viral proteins and the RNA genome into the host cell, initiating an infectious cycle. This
HIV coreceptors, cell tropism and inhibition by chemokine receptor ligands.: Mol Membr Biol. 1999 Jan-Mar;16(1):49-55. Unique Identifier : AIDSLINE MED/99265141; Clapham PR; Reeves JD; Simmons G; Dejucq N; Hibbitts S; McKnight A; Section of Virology, Chester Beatty Laboratories, Institute of; Cancer Research, London, UK.; HIV is a persistent virus that survives and replicates despite an onslaught by the host s immune system. A strategy for cell entry, requiring the use of two receptors, has evolved that may help evade neutralizing antibodies. HIV and SIV usually require both CD4 and a seven transmembrane (7TM) coreceptor for infection.
HIV-1 envelope determinants for cell tropism and chemokine receptor use.: Mol Membr Biol. 1999 Jan-Mar;16(1):57-65. Unique Identifier : AIDSLINE MED/99265142; Hoffman TL; Doms RW; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.; Isolates of human immunodeficiency virus type-1 (HIV-1) display marked differences in their ability to replicate in macrophages and transformed T-cell lines in vitro, a property that has important implications for disease pathogenesis. The restriction in replication between these two CD4-positive cell types is largely
The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus.: Mol Membr Biol. 1999 Jan-Mar;16(1):67-72. Unique Identifier : AIDSLINE MED/99265143; Willett BJ; Hosie MJ; Department of Veterinary Pathology, University of Glasgow; Veterinary School, UK.; Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mec
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 May 28;9(22):199-200. Unique Identifier : AIDSLINE MED/99319380
[Ethical problems in nursing: recognition and professional conduct, as a nurse, regarding HIV infection of patients due to blood products]: Nihon Kango Kagakkaishi. 1997 Dec;17(4):69-75. Unique Identifier : AIDSLINE MED/99354831; Horii M; Takatani Y; Mori E; Andoh H; Ohta K; Okaya K; Katada N; Katsuta H; Kawamura S; Doi Y; Nakanishi M; Minami Y
Inhibition of endothelial receptor expression and of T-cell ligand activity by mycophenolate mofetil.: Transpl Immunol. 1998 Dec;6(4):251-9. Unique Identifier : AIDSLINE MED/99272167; Blaheta RA; Leckel K; Wittig B; Zenker D; Oppermann E; Harder S; Scholz M; Weber S; Schuldes H; Encke A; Markus BH; Department of General Surgery, Johann Wolfgang Goethe-University,; Frankfurt am Main, Germany. Blaheta@em.uni-frankfurt.de; The novel immunosuppressive drug mycophenolate mofetil (CellCept, MMF) blocks DNA-synthesis by the inhibition of the enzyme inosine monophosphate dehydrogenase (IMDH). IMDH is also involved in the synthesis of adhesion receptors which are known to play an important role in the regulation of cell-cell contacts. Therefo
The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentans.: Unique Identifier : AIDSLINE MED/99280355; Yirmiya R; Weidenfeld J; Barak O; Avitsur R; Pollak Y; Gallily R; Wohlman A; Ovadia H; Ben-Hur T; Intracerebral administration of Mycoplasma fermentans (MF), a small microorganism that has been found in the brain of some AIDS patients, induces behavioral and neuroendocrine alterations in rats. To examine the role of tumor necrosis factor-alpha (TNFalpha) and interleukin-1 (IL-1) in mediating these effects we measu
Differences and similarities between chronic obstructive pulmonary disease and asthma.: Unique Identifier : AIDSLINE MED/99352270; Jeffery PK; Asthma and chronic obstructive pulmonary disease (COPD) are complex conditions with imprecise definitions, which make definitive morphological comparisons difficult. The airways in asthma are occluded by tenacious plugs of exudate and mucus, and there is fragility of airway surface epithelium, thickening of the reticu
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.: Clin Exp Allergy. 1999 Jun;29 Suppl 2:33-6. Unique Identifier : AIDSLINE MED/99352272; Kapsenberg ML; Hilkens CM; Wierenga EA; Kalinski P; Department of Cell Biology and Histology, Academic Medical Center; of the University of Amsterdam, Amsterdam, The Netherlands.; Optimal clearance of the various pathogen types encountered by the human body requires the selective activation of particular cellular and/or humoral immune responses. The orchestration of the types of effector responses is directed by Th cells through the production of type 1 (Th1 cell-associated) and type 2 (Th2 cel
Development of T-cell memory against inhalant allergens: risks for the future.: Clin Exp Allergy. 1999 Jun;29 Suppl 2:8-13. Unique Identifier : AIDSLINE MED/99352269; Holt PG; Department of Cell Biology, TVW Telethon Institute for Child; Health Research, West Perth, Australia.; Recent evidence suggests that the development of chronic allergic respiratory disease is a biphasic process. Phase 1 commonly occurs during early childhood and in many instances appears to be initiated in utero. This involves initial priming of the Th-cell system against ubiquitous environmental allergens, and subsequ
Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses.: Unique Identifier : AIDSLINE MED/99330957; Slattery JP; Franchini G
[Infectious esophagitis]: Gastroenterol Hepatol. 1999 Jun-Jul;22(6):302-8. Unique Identifier : AIDSLINE MED/99338640; Arenas Mirave JI; Montalvo Ollobarren II; Gil Lasa I; Servicio de Aparato Digestivo, Hospital Aranzazu, San; Sebastian.
IMGT, the international ImMunoGeneTics database: a new design for immunogenetics data access.: Medinfo. 1998;9 Pt 1:351-5. Unique Identifier : AIDSLINE MED/99312470; Giudicelli V; Chaume D; Mennessier G; Althaus HH; Muller W; Bodmer J; Malik A; Lefranc MP; Laboratoire d'ImmunoGenetique Moleculaire, LIGM, UMR 5535; (CNRS, Universite Montpellier II), France.; IMGT, the international ImMunoGeneTics database is an integrated database specializing in Immunoglobulins (Ig), T-cell receptors (TcR) and MHC molecules of all vertebrate species, created by Marie-Paule Lefranc, University of Montpellier, CNRS, Montpellier, France (Nucleic Acids Re
Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A.: Chung Hua I Hsueh Tsa Chih (Taipei). 1999 Jul;62(7):450-4. Unique Identifier : AIDSLINE MED/99346734; Hsu HC; Chen YF; Ho CH; Department of Medicine, Veterans General Hospital-Taipei, Taiwan,; ROC.; BACKGROUND: Plasma-derived factor VIII concentrates used in the treatment of hemophilia A have the potential danger of transfusion-associated viral disease. The safety and efficacy of a recombinant factor VIII preparation for the treatment of this disorder were evaluated in this study. METHODS: We compared the pharmac
Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate.: Unique Identifier : AIDSLINE MED/99328843; Doniger J; Muralidhar S; Rosenthal LJ; Department of Microbiology and Immunology, Georgetown University; Medical Center, Washington, D.C. 20007, USA.; This review is an update on the transforming genes of human cytomegalovirus (HCMV) and human herpesvirus 6 (HHV-6). Both viruses have been implicated in the etiology of several human cancers. In particular, HCMV has been associated with cervical carcinoma and adenocarcinomas of the
Trait-like immunological and hematological measures in female rhesus across varied environmental conditions.: Am J Primatol. 1999;48(3):197-223. Unique Identifier : AIDSLINE MED/99308702; Lilly AA; Mehlman PT; Higley JD; Dept. of Anthropology, SUNY, Stony Brook, New York, USA.; In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and h
Mycobacterium avium interaction with macrophages and intestinal epithelial cells.: Front Biosci. 1999 Jul 15;4:D582-8. Unique Identifier : AIDSLINE MED/99348569; Sangari FJ; Parker A; Bermudez LE; Kuzell Institute for Arthritis & Infectious Diseases, California; Pacific Medical Center Research Institute, 2200 Webster Street,; Suite 305, San Francisco, CA 94115, USA.; Mycobacterium avium is an environmental microorganism that is adapted to live both in the environment (mainly in water and soil) and in bird, fish and mammal hosts. In humans, M. avium infection is seen in patients with some sort of immunosuppression, such as patients with chronic lung disease, and Acquired Immunodefi
Immunological and molecular characterization of an aggressive murine lymphoma variant: modulation in vitro and in vivo.: Int J Oncol. 1999 Jul;15(1):71-9. Unique Identifier : AIDSLINE MED/99307655; Jurianz K; von Hoegen P; Schirrmacher V; Division of Cellular Immunology, German Cancer Research Center,; D-69120 Heidelberg, Germany.; The highly metastatic murine ESb-L lymphoma was analyzed with respect to its possible origin and phenotype modulation. By determining the methylation status of the CD8 gene an early thymic origin of the ESb-L lymphoma cells is suggested. It revealed that the precursors of ESb-L cells had at least one CD8 allele expres
MAC prophylaxis in the era of polypharmacy.: WMJ. 1999 May-Jun;98(3):46-8. Unique Identifier : AIDSLINE MED/99342624; Sawhney N; Infectious Disease Consultants of Wisconsin, Milwaukee 53215,; USA.; In the advanced stages of AIDS, patients are increasingly susceptible to disseminated Mycobacterium avium-intracellulare (MAC) infection, causing significant morbidity and mortality. It has been shown that prophylaxis against this infection is effective in reducing the incidence as well as the symptoms of MAC. Althoug
Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes.: Chem Biol Interact. 1999 Jun 1;121(1):37-48. Unique Identifier : AIDSLINE MED/99345337; Reinach B; de Sousa G; Dostert P; Ings R; Gugenheim J; Rahmani R; Pharmacia and Upjohn, Drug Metabolism Research, Nerviano, Italy.; The aim of this study was to evaluate rifabutin (RBT) and rifampicin (RIF) capabilities in inducing various xenobiotic metabolizing enzymes such as cytochromes P450 (CYPs) and UDP-glucuronosyl-transferases (UGTs) in cultured fresh and cryopreserved human hepatocytes. Enzyme induction was assessed through the use of se
Are HIV lookbacks worthwhile? Outcome of an exercise to notify patients treated by an HIV infected health care worker. Incident Management Teams [see comments]: Commun Dis Public Health. 1999 Jun;2(2):126-9. Unique Identifier : AIDSLINE MED/99331159; Donnelly M; Duckworth G; Nelson S; Wehner H; Gill N; Nazareth B; Cummins A; PHLS Communicable Disease Surveillance Centre, Thames.; This report describes the management and outcome of one of the largest exercises undertaken in the United Kingdom to notify patients exposed to an HIV infected health care worker. Eighty-six per cent (1597/1852) of patients on whom the infected junior doctor in obstetrics and gynaecolo
Lookback in angst [editorial; comment]: Commun Dis Public Health. 1999 Jun;2(2):79-81. Unique Identifier : AIDSLINE MED/99331149; Weller I
The global impact of HIV infection and disease.: Commun Dis Public Health. 1999 Jun;2(2):85-95. Unique Identifier : AIDSLINE MED/99331152; Nicoll A; Gill ON; HIV and STD Division, PHLS Communicable Disease Surveillance; Centre, London. anicoll@phls.co.uk; Patterns of HIV infection and disease are changing. HIV will soon enter the top five causes of death worldwide and is now believed to cause more deaths than malaria. Commonwealth countries account for around 60% of prevalent HIV infections worldwide. Around half of all global HIV transmissions are to people under 25 y
Primary T-cell and activated macrophage response associated with tumor protection using peptide/poly-N-acetyl glucosamine vaccination.: Clin Cancer Res. 1999 May;5(5):1173-82. Unique Identifier : AIDSLINE MED/99280221; Maitre N; Brown JM; Demcheva M; Kelley JR; Lockett MA; Vournakis J; Cole DJ; Department of Surgery, Medical University of South Carolina,; Charleston 29425, USA.; The mode of peptide-based cancer vaccine administration critically affects the ability to achieve a clinically relevant tumor-specific response. We have previously shown (Cole et al., Clin. Cancer Res., 3: 867-873, 1997) that a specific formulation of the polysaccharide poly-N-acetyl glucosamine (p-GlcNAc, designated
Sexuality and sex education at home and school.: Adolesc Med. 1999 Jun;10(2):195-209, v. Unique Identifier : AIDSLINE MED/99298842; Kirby D; Department of Research, ETR Associates, Santa Cruz, California; 95061-1830, USA.; This article reviews numerous studies of parent-adolescent communication about sexuality and 30 studies of sexuality and HIV education programs. Although parent-adolescent communication about sexuality has increased during the last few decades, both the occurrence and the quality of this communication could still be g
Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases.: Bioorg Med Chem Lett. 1999 Apr 19;9(8):1179-84. Unique Identifier : AIDSLINE MED/99258861; Kurihara S; Tsumuraya T; Fujii I; Biomolecular Engineering Research Institute, Suita, Osaka, Japan.; Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.
Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.: Int J Mol Med. 1999 Jun;3(6):633-7. Unique Identifier : AIDSLINE MED/99274687; Sales ME; Espanol AJ; Sterin-Borda L; Borda E; de Bracco MM; Instituto de Oncologia Angel H. Roffo, Buenos Aires, Argentina.; In this work we demostrate that IgA purified from HIV infected patients recognizes a band with a molecular weight corresponding to radiolabelled ileal muscarinic acethylcholine receptors (mAChR) by immunoblotting. HIV+-IgA triggers the signals that are the consequence of mAChR stimulation in the intestine, regulating
Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation.: Clin Immunol. 1999 Jul;92(1):103-10. Unique Identifier : AIDSLINE MED/99343956; Di Marzio L; Moretti S; D'Alo S; Zazzeroni F; Marcellini S; Smacchia C; Alesse E; Cifone MG; De Simone C; Department of Experimental Medicine, University of L'Aquila,; L'Aquila, Italy.; The aim of this study was to investigate the impact of long-term acetyl-L-carnitine administration on CD4 and CD8 absolute counts, apoptosis, and insulin-like growth factor-1 (IGF-1) serum levels in HIV-1-infected subjects. The generation of cell-associated ceramide and HIV-1 viremia were also investigated. Eleven asy
Enhanced IFN-gamma production in vitro by CD8+ T cells in hemophiliacs with AIDS as demonstrated on the single-cell level.: Clin Immunol. 1999 Jul;92(1):111-7. Unique Identifier : AIDSLINE MED/99343957; Pae Y; Minagawa H; Hayashi J; Kashiwagi S; Yanagi Y; Faculty of Medicine, Kyushu University, Fukuoka, Japan.; We examined T cells from HIV-infected hemophiliacs under antiviral therapy, on the single-cell level, for cytokine production in vitro in response to stimulation. The percentage of IL-2-producing cells was markedly decreased among both CD3+CD8- and CD3+CD8+ cells, while the proportion of IFN-gamma-producing cells was
Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells [see comments]: Clin Immunol. 1999 Jul;92(1):14-24. Unique Identifier : AIDSLINE MED/99343947; Kaushal S; Landay AL; Lederman MM; Connick E; Spritzler J; Kuritzkes DR; Kessler H; Levine BL; St. Louis DC; June CH; Henry M. Jackson Foundation for the Advancement of Military; Medicine, U.S. Military HIV Research Program, Bethesda, Maryland; 20889, USA.; Changes in mean telomeric terminal restriction fragment (TRF) length were examined as a marker for cellular replicative history in HIV-1-infected individuals after institution of anti-retroviral therapy (ART). Increases in mean T cell TRF lengths were observed in most patients following therapy; however, the contribut
Primary HIV infection of infants: the effects of somatic growth on lymphocyte and virus dynamics [see comments]: Clin Immunol. 1999 Jul;92(1):25-33. Unique Identifier : AIDSLINE MED/99343948; Krogstad P; Uittenbogaart CH; Dickover R; Bryson YJ; Plaeger S; Garfinkel A; Jonsson Comprehensive Cancer Center, University of California,; Los Angeles, California 90095-5217, USA.; Acute HIV infection is characterized by the appearance of high concentrations of virus in the peripheral blood. In adults, this high-level viremia spontaneously abates after several weeks. In contrast, after perinatal infection of infants, blood virus levels remain high for many months, during which the concentration
HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool [editorial; comment]: Clin Immunol. 1999 Jul;92(1):3-5. Unique Identifier : AIDSLINE MED/99343945; Haynes BF
Interferon-gamma therapy reduces blood leukocyte levels in patients with atopic dermatitis: correlation with clinical improvement.: Clin Immunol. 1999 Jul;92(1):49-55. Unique Identifier : AIDSLINE MED/99343950; Ellis CN; Stevens SR; Blok BK; Taylor RS; Cooper KD; Department of Dermatology, University of Michigan Medical School; and Veterans Affairs Medical Center, Ann Arbor, Michigan 48109,; USA.; Atopic dermatitis (AD) is a chronic inflammatory skin disease with abnormalities of both cellular and humoral immunity. Subcutaneous recombinant human interferon-gamma (IFN-gamma) provides therapeutic benefit to AD patients. In contrast to expectations, IFN-gamma does not cause a decrease in the elevated levels of cir
Chagas' disease encephalitis: intense CD8+ lymphocytic infiltrate is restricted to the acute phase, but is not related to the presence of Trypanosoma cruzi antigens.: Clin Immunol. 1999 Jul;92(1):56-66. Unique Identifier : AIDSLINE MED/99343951; Silva AA; Roff; Marino AP; dos Santos PV; Quirico-Santos T; Paiva CN; Lannes-Vieira J; Department of Immunology, Oswaldo Cruz Institute-Fiocruz, Rio de; Janeiro, Rio de Janeiro, 21045-900, Brazil.; Central nervous system (CNS) damage can occur during Chagas disease, especially in children and immunosuppressed patients. During the acute phase, amastigotes are rarely found, but inflammatory infiltrates are scattered throughout the CNS. Moreover, peripheral lymphocytes and antibodies recognizing neural components
Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity.: Clin Immunol. 1999 Jul;92(1):90-6. Unique Identifier : AIDSLINE MED/99343954; Xin KQ; Lu Y; Hamajima K; Fukushima J; Yang J; Inamura K; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, 236, Japan.; Cytokines play important roles in regulating immune response. This study evaluated the adjuvant effect of an expression plasmid encoding RANTES (regulated on activation normal T-cell expressed and secreted) chemokine on the immunity induced by a DNA vaccine. This vaccine consists of expression plasmids encoding the en
Unusual neurological manifestations of primary human immunodeficiency virus infection.: Eur J Neurol. 1998 Jul;5(4):369-73. Unique Identifier : AIDSLINE MED/99338343; Hassin-Baer S; Steiner I; Achiron A; Sadeh M; Vonsover A; Hassin D; Department of Neurology, Chaim Sheba Medical Center,; Tel-Hashomer, Israel.; The nervous system may be involved during primary human immunodeficiency virus (HIV) infection. Recognized clinical syndromes include meningitis, meningo-encephalitis, myelopathy, polyneuropathy and rhabdomyolysis. We report three patients with unusual neurological presentations of primary HIV infection: intracranial
The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients.: Mol Diagn. 1999 Mar;4(1):37-43. Unique Identifier : AIDSLINE MED/99248376; Burke DG; Leonard DG; Imperiale TF; Valdez H; Karaman B; Shick E; Kalayjian RC; Departments of Medicine, Pathology and Radiology, University; Hospitals of Cleveland, MetroHealth Medical Center, Cleveland, OH; 44109-1998, USA.; BACKGROUND: Polymerase chain reaction (PCR) assays of cerebrospinal fluid (CSF) for cytomegalovirus ( CMV ) DNA have facilitated the diagnosis of CMV-associated central nervous system disease in AIDS patients. We attempt to cor
The re-use of irrigating equipment for flexible cystoscopy is not safe.: BJU Int. 1999 Jun;83(9):948-53. Unique Identifier : AIDSLINE MED/99296783; Molina-Navarro C; Bhatia BS; Awogu O; Ochai J; Jones MA; Department of General Surgery, Royal Bournemouth Hospital,; Bournemouth, UK.; OBJECTIVE: To determine the incidence of fluid reflux from the lower urinary tract into the connecting tubing used for irrigation in patients undergoing flexible cystoscopy. PATIENTS AND METHODS: The study was conducted in 94 consecutive male and female patients attending routine outpatient flexible cystoscopy lists.
Advances in the diagnosis and treatment of human papillomavirus infections.: Clin Obstet Gynecol. 1999 Jun;42(2):206-20. Unique Identifier : AIDSLINE MED/99298980; Sedlacek TV; Allegheny University, Philadelphia, PA 19146, USA.; During the past decade, much has been learned about the natural history of HPV. Most infections occur early in one s sexual life. The overwhelming majority of infections are cleared by the host immune system and never present as warts or neoplasia. Certain patient behavior such as smoking, frequent sex with many diffe
Data and safety monitoring in the Concorde and Alpha trials.: Control Clin Trials. 1999 Jun;20(3):207-28. Unique Identifier : AIDSLINE MED/99284387; Armitage P; St Peter's College, Oxford, United Kingdom.; Concorde was a randomized trial to compare immediate and deferred zidovudine ( AZT ) treatment for persons with asymptomatic HIV infection. Alpha was a randomized trial to compare the efficacy of two doses of didanosine (ddI), in persons with symptomati
Data and safety monitoring in the Delta trial.: Unique Identifier : AIDSLINE MED/99284388; Armitage P; St. Peter's College, Oxford, United Kingdom.; Delta was a randomized trial designed to test whether combinations of zidovudine ( AZT ) with didanosine (ddI) or zalcitabine ( ddC ) were more effective than AZT alone for HIV-infected p
Relationship between event rates and treatment effects in clinical site differences within multicenter trials: an example from primary Pneumocystis carinii prophylaxis.: Control Clin Trials. 1999 Jun;20(3):253-66. Unique Identifier : AIDSLINE MED/99284390; Ioannidis JP; Dixon DO; McIntosh M; Albert JM; Bozzette SA; Schnittman SM; HIV Research Branch, Division of AIDS, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland, USA.; The results of multicenter clinical trials may differ across participating clinical sites. We present a diagnostic approach for evaluating this diversity that emphasizes the relationship between the observed event rates and treatment effects. We use as an example a trial of sequential strategies of Pneumocystis prophy
Acquired immunodeficiency syndrome, Pneumocystis carinii pneumonia, and the danger of prognostication: apples to apples [editorial; comment]: Crit Care Med. 1999 Jun;27(6):1043-4. Unique Identifier : AIDSLINE MED/99323323; Peruzzi WT
Pneumocystis carinii pneumonia requiring intensive care management: survival and prognostic study in 110 patients with human immunodeficiency virus [see comments]: Crit Care Med. 1999 Jun;27(6):1109-15. Unique Identifier : AIDSLINE MED/99323343; Bedos JP; Dumoulin JL; Gachot B; Veber B; Wolff M; Regnier B; Chevret S; Service de Reanimation des Maladies Infectieuses, Groupe; Hospitalier Bichat-Claude Bernard, Paris, France.; OBJECTIVE: To perform a descriptive study of patients with acute respiratory failure secondary to acquired immunodeficiency syndrome-related Pneumocystis carinii pneumonia and to identify variables that are predictive of death within 3 months. DESIGN: Case series study. SETTING: Infectious disease intensive care unit
Establishment of T-helper type 2 clone-induced eosinophilia in mouse conjunctiva.: Exp Eye Res. 1999 Jul;69(1):69-74. Unique Identifier : AIDSLINE MED/99307112; Hamada M; Sawa K; Nakata K; Ophthalmic Research Division, Santen Pharmaceutical Co., Ltd.,; 8916-16 Takayama-cho, Ikoma-shi, 630-0101, Japan.; Eosinophil infiltration is one of the aspects of the inflammatory response to an allergen. The aim of this study was to establish T-helper type-2 (Th2)-induced conjunctival eosinophilia in mice to evaluate the effect of anti-allergic drugs. Th2 clone, D10.G4.1. (D10) with its specific antigen, conalbumin was co-inject
Kaposi's sarcoma associated with Castleman's disease [letter]: Eur J Haematol. 1999 Jul;63(1):67-70. Unique Identifier : AIDSLINE MED/99341408; Zeidman A; Fradin Z; Cohen AM; Mittelman M
New substrates of DNA polymerases.: FEBS Lett. 1999 Jun 18;453(1-2):6-10. Unique Identifier : AIDSLINE MED/99330158; Victorova L; Sosunov V; Skoblov A; Shipytsin A; Krayevsky A; Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, Moscow.; Bis-(2 -deoxynucleoside) 5 ,5 -tetraphosphates and bis-(2 -deoxynucleoside) 5 ,5 -triphosphates were shown to be a new type of substrate for several DNA polymerases of human, bacterial and viral origin. Their substrate properties depend both on their structure and on the nature of the enzyme. They are incorporated by
Partial nucleotide sequencing of the NS3/helicase region of hepatitis G virus to prove vertical transmission.: FEMS Microbiol Lett. 1999 Jun 15;175(2):273-9. Unique Identifier : AIDSLINE MED/99314157; Takayama S; Miura T; Tominaga T; Taki M; Matsuo S; Sugii S; Shimotohno K; Division of Laboratory Research, St. Marianna University; Yokohamashi Seibu Hospital, Kanagawa, Japan.; stakayam@mb.kcom.ne.jp; To study non-parental transmission of hepatitis G virus and/or GB virus C (HGV/GBV-C), we sequenced and compared the NS3/helicase region of the virus for five HGV/GBV-C RNA-positive mothers and their 11 children who had experienced neither blood transfusion nor overt hepatitis and were negative for HBV, HCV and HIV, e
Anti-P30-52 monoclonal antibody cross-reacted to Env V3 and inhibited the viral multiplication of HIV-1-infected MT-4 cells.: Hybridoma. 1999 Apr;18(2):139-47. Unique Identifier : AIDSLINE MED/99306681; Ota A; Bautista AN; Yadav ML; Ueda S; Department of Neurovirology, Research Institute for Microbial; Diseases, Osaka University, Suita City, Japan.; It is well known that the anti-p17 antibody titer decreases with the disease progression among human immunodeficiency virus type 1 (HIV-1) carriers. We previously established several murine anti-p17 monoclonal antibodies (MAbs) to investigate the immunological role of p17, and to further characterize these MAbs, we ex
Cross-reactivity of anti-HIV-1-p17-derivative peptide (P30-52) antibody to Env V3 peptide.: Hybridoma. 1999 Apr;18(2):149-57. Unique Identifier : AIDSLINE MED/99306682; Ota A; Tanaka-Taya K; Ueda S; Department of Neurovirology, Research Institute for Microbial; Diseases, Osaka University, Suita City, Japan.; Strong antibody responses are often seen in human immunodeficiency virus type 1 (HIV-1) carriers, but it is not known whether these antibodies are effective in the inhibition of disease progression. In this study, we examined antigenic epitopes for anti-HIV-1 p17 antibody (p17 Ab) in an HIV-1 carrier s serum, and foun
B lymphocytes in lymph nodes and peripheral blood are important for binding immune complexes containing HIV-1.: Immunology. 1999 Apr;96(4):612-9. Unique Identifier : AIDSLINE MED/99250346; Jakubik JJ; Saifuddin M; Takefman DM; Spear GT; Department of Immunology and Microbiology, Rush University, 1653; W. Congress Parkway, Chicago, IL. 60612, USA.; We investigated the interaction of HIV immune complexes (HIV IC) with mononuclear cells from lymph nodes and blood. While antibody alone did not affect binding of HIV IC to mononuclear cells, antibody plus complement increased binding by as much as 10-fold and complement alone also increased binding slightly. Most of
Antigen-specific B and T cells in human/mouse radiation chimera following immunization in vivo.: Immunology. 1999 Apr;96(4):634-41. Unique Identifier : AIDSLINE MED/99250349; Bocher WO; Marcus H; Shakarchy R; Dekel B; Shouval D; Galun E; Reisner Y; Department of Immunology, The Weizmann Institute of Science,; Rehovot, Israel.; Adoptive transfer of human peripheral blood mononuclear cells (PBMC) into mice with severe combined immunodeficiency (SCID) or into lethally irradiated BALB/c mice radioprotected with SCID bone marrow, leads to marked engraftment of human T and B cells. In such chimeras, human serum antibody responses can be stimulate
The role of IL-12 in the control of MCMV is fundamentally different in mice with a retroviral immunodeficiency syndrome (MAIDS).: Unique Identifier : AIDSLINE MED/99250807; Peacock CD; Price P; The present study investigates the susceptibility of C57BL mice exhibiting T cell immunodeficiency and lymphadenopathy induced by LP-BM5 murine leukaemia virus (MAIDS) to murine cytomegalovirus (MCMV). Treatment of normal (M-) mice with anti-IL-12 increased the contribution of IgG1
Dr. P. C. Sen Memorial Award Paper. A study of HIV infection in thalassaemia patients of rural Bengal.: Indian J Public Health. 1998 Jul-Sep;42(3):81-7. Unique Identifier : AIDSLINE MED/99317749; Sur D; Chakraborty AK; Mukhopadhyay SP; Thalassaemia patients receiving repeated blood transfusions are vulnerable to transfusion related infections. HIV infection is the most life threatening of them all. Blood being the most efficient mode of transmission of HIV, increases the risk of infection even further. Although the National AIDS Control programme ha
Mucocutaneous manifestations of HIV infection: a retrospective analysis of 145 cases in a Chinese population in Malaysia.: Int J Dermatol. 1999 Jun;38(6):457-63. Unique Identifier : AIDSLINE MED/99323716; Jing W; Ismail R; Department of Medicine, University of Malaya, Kuala Lumpur,; Malaysia.; BACKGROUND: Mucocutaneous lesions directly related to human immunodeficiency virus (HIV) infection usually present as initial manifestations of immune deficiency. The most common mucocutaneous lesions are Kaposi s sarcoma, histoplasmosis, oro-esophageal candidiasis, oral hairy leukoplakia, and, in Asia, Penicillium ma
[High viral content in men's semen during highly active antiretroviral therapy]: Hautarzt. 1999 Apr;50(4):317. Unique Identifier : AIDSLINE MED/99283358
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer.: J Biol Chem. 1999 Jul 9;274(28):19885-93. Unique Identifier : AIDSLINE MED/99321920; Powell MD; Beard WA; Bebenek K; Howard KJ; Le Grice SF; Darden TA; Kunkel TA; Wilson SH; Levin JG; Laboratory of Molecular Genetics, NICHD, National Institutes of; Health, Bethesda, Maryland 20892, USA.; During retrovirus replication, reverse transcriptase (RT) must specifically interact with the polypurine tract (PPT) to generate and subsequently remove the RNA primer for plus-strand DNA synthesis. We have investigated the role that human immunodeficiency virus-1 RT residues in the alphaH and alphaI helices in the th
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.: J Cell Biol. 1999 Jun 28;145(7):1471-82. Unique Identifier : AIDSLINE GENBANK/AJ242778; Heyninck K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R; Department of Molecular Biology, Flanders Interuniversity; Institute for Biotechnology, University of Ghent, B-9000 Ghent,; Belgium.; The zinc finger protein A20 is a tumor necrosis factor (TNF)- and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression. However, the molecular mechanism by which A20 exerts this effect is still unclear. We show that A20 does not inhibit TNF- indu
Fatal herpetic hepatitis in adult following short corticotherapy: a case report.: Intensive Care Med. 1999 Apr;25(4):415-7. Unique Identifier : AIDSLINE MED/99271947; Seksik P; Gozlan J; Guitton C; Galula G; Maury E; Offenstadt G; Medical Intensive Care Unit, Hopital Saint-Antoine, Assistance; Publique-Hopitaux de Paris, France.; Herpes simplex virus hepatitis (HSV hepatitis) is an uncommon and severe complication of HSV type 1 and HSV type 2 infection. HSV hepatitis affects mostly immunocompromised patients. We report the case of a young man without any previous known immunodeficiency who developed fatal HSV hepatitis in the first 8 days of o
Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity.: J Allergy Clin Immunol. 1999 Jul;104(1):163-8. Unique Identifier : AIDSLINE MED/99328936; Shimada Y; Sato S; Hasegawa M; Tedder TF; Takehara K; Department of Dermatology, Kanazawa University School of; Medicine, Kanazawa, Japan.; BACKGROUND: L-selectin mediates leukocyte rolling on endothelium at sites of inflammation, suggesting that L-selectin may be involved in the development of cutaneous lesions of atopic dermatitis (AD). After leukocyte activation, L-selectin is rapidly shed from the cell surface. OBJECTIVE: The purpose of this study was
Adoptively transferred late allergic response is inhibited by IL-4, but not IL-5, antisense oligonucleotide.: J Allergy Clin Immunol. 1999 Jul;104(1):205-14. Unique Identifier : AIDSLINE MED/99328945; Molet S; Ramos-Barbon D; Martin JG; Hamid Q; Meakins-Christie Laboratories, McGill University, Montreal,; Quebec, Canada.; BACKGROUND: We have shown previously that the late airways response (LAR) can be transferred by ovalbumin-primed CD4(+) T lymphocytes in Brown Norway rats. This response is associated with an increase of eosinophils and high expression of TH2 cytokines (IL-4 and IL-5) in bronchoalv
Eosinophil involvement and serum IgE level in HIV-1-infected children.: J Allergy Clin Immunol. 1999 Jul;104(1):245-7. Unique Identifier : AIDSLINE MED/99328954; Onorato J; Esposito S; Scovena E; Morandi B; Morelli M; Pizzi M; Zisa G; Marchisio P; Principi N; Paediatric Department IV, University of Milan, L. Sacco Hospital,; Milan, Italy.
Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigens.: J Allergy Clin Immunol. 1999 Jul;104(1):37-45. Unique Identifier : AIDSLINE MED/99328919; Hauk PJ; Wenzel SE; Trumble AE; Szefler SJ; Leung DY; Divisions of Allergy-Immunology, National Jewish Medical and; Research Center, Denver, CO, USA.; BACKGROUND: T cells are thought to play an important role in the pathogenesis of chronic asthma. The immunologic triggers that contribute to poorly controlled asthma are unknown but may include infectious agents. Superantigens (SAgs), which stimulate T cells expressing selected T-cell receptor (TCR) beta-chain variabl
Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers.: Infect Control Hosp Epidemiol. 1999 Jun;20(6):428-30. Unique Identifier : AIDSLINE MED/99321070; D'Amico R; Pinto LA; Meyer P; Landay AL; Harris AA; Clerici M; Berzofsky JA; Shearer GM; Kessler HA; Department of Medicine, Rush Medical College, Chicago, Illinois,; USA.; We evaluated the effects of zidovudine postexposure prophylaxis (PEP) on the development of human immunodeficiency virus (HIV) envelope-specific cytotoxic T-lymphocyte responses in 20 healthcare workers with occupational exposures to HIV. Seven healthcare workers were treated with zidovudine PEP. Only 1 of 7 treated,
Occupational exposure and voluntary human immunodeficiency virus testing: a survey of Maryland hospitals.: Infect Control Hosp Epidemiol. 1999 Jun;20(6):430-2. Unique Identifier : AIDSLINE MED/99321071; Solomon L; Thompson C; Squiers L; Wulff K; Benjamin G; Department of Health and Mental Hygiene, AIDS Administration,; Baltimore, Maryland 21202, USA.; A survey was conducted to estimate how often healthcare providers were exposed to patients blood and the percentage of incidents in which patients agreed to human immunodeficiency virus (HIV) testing. Data from 38 hospitals with 53,508 employees revealed 2,244 exposures. Of 1,732 requests for information regarding th
Nurses failure to appreciate the risks of infection due to needle stick accidents: a hospital based survey.: J Hosp Infect. 1999 May;42(1):53-9. Unique Identifier : AIDSLINE MED/99291390; Leliopoulou C; Waterman H; Chakrabarty S; Royal Free Hospital Medical School, London.; One of the most important occupational risks to healthcare workers is exposure is to blood-borne viruses. This study examined nurses perceptions of risk of contracting infection following single or multiple exposure to blood or body fluids. Two hundred and ninety nurses were surveyed using a questionnaire. One hundre
A two-type model for the Cuban national programme on HIV/AIDS.: IMA J Math Appl Med Biol. 1999 Jun;16(2):143-54. Unique Identifier : AIDSLINE MED/99327509; Lounes R; de Arazoza H; Universite Paris V, Laboratoire de Statistique Medicale, UA; CNRS 1323, France.; We study deterministic and stochastic versions of a birth and death process for a two-type population with immigration for both types. For the stochastic model we consider the case where the rates are time dependent, and also when they are constant, as is the case in our AIDS application. We derive the probability gen
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas.: J Endod. 1999 Apr;25(4):239-42. Unique Identifier : AIDSLINE MED/99354679; Hren NI; Gubina M; Ihan A; Clinic for Maxillofacial and Oral Surgery, University Clinical; Centre Ljubljiana, Slovenia.; Seventeen dental periapical lesions were investigated to study bacterial colonization. Periapical lesions, obtained after apicotomy, were also enzymatically desegregated to quantitatively analyze lymphocyte subpopulations by flow cytometry. Fourteen samples yielded a positive bacterial growth when homogenized and cult
Elective cesarean delivery to prevent vertical transmission of HIV.: J Fam Pract. 1999 Jul;48(7):493-4. Unique Identifier : AIDSLINE MED/99355193; DuBard CA; Newton WP; University of North Carolina, Chapel Hill, USA.
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity.: J Med Chem. 1999 Jul 15;42(14):2561-8. Unique Identifier : AIDSLINE MED/99340126; Cirrincione G; Almerico AM; Barraja P; Diana P; Lauria A; Passannanti A; Musiu C; Pani A; Murtas P; Minnei C; Marongiu ME; La Colla P; Istituto Farmacochimico, Universita degli Studi, Via Archirafi; 32, 90123 Palermo, Italy.; Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization of substituted 2-(2-aminophenyl)indoles followed by an intramolecular coupling reaction of the diazonium group with the indole nitrogen. To obtain the indolobenzotriazine system it was necessary to protect the 3 po
Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.: J Med Chem. 1999 Jul 15;42(14):2662-72. Unique Identifier : AIDSLINE MED/99340136; Xie L; Takeuchi Y; Cosentino LM; Lee KH; Natural Products Laboratory, Division of Medicinal Chemistry and; Natural Products, School of Pharmacy, University of North; Carolina, Chapel Hill, North Carolina 27599, USA.; To explore the structural requirements of (+)-cis-khellactone derivatives as novel anti-HIV agents, 24 monosubstituted 3 , 4 -di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives were synthesized asymmetrically. These compounds included 4 isomeric monomethoxy analogues (3-6), 4 isomeric monomethyl analogues (7-10
Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events.: J Mol Biol. 1999 Jul 2;290(1):21-35. Unique Identifier : AIDSLINE MED/99318866; Biggs TE; Cooke SJ; Barton CH; Harris MP; Saksela K; Mann DA; Southampton General Hospital, Southampton, SO16 6YD, UK.; Human immunodeficiency virus type 1 (HIV-1) Nef is important for viral infectivity and pathogenicity. HIV-1 infection is associated with inappropriate activation and defects in the function of monocytes/macrophages. We have studied the effects of HIV-1 Nef in the murine (RAW264.7) and human (THP-1) monocyte-macrophage
Ankle clonus and thiocyanate, linamarin, and inorganic sulphate excretion in school children in communities with Konzo, Mozambique.: J Trop Pediatr. 1999 Jun;45(3):139-42. Unique Identifier : AIDSLINE MED/99329414; Cliff J; Nicala D; Saute F; Givragy R; Azambuja G; Taela A; Chavane L; Gani A; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo,; Mozambique. jcliff@mail.tropical.co.mz; We examined 397 school children for ankle clonus in five communities in three districts affected by konzo, spastic paraparesis associated with cassava consumption. From a subsample of 131 children, we analysed urine specimens for urinary thiocyanate, linamarin, and inorganic sulphate. The proportion of children with c
Low birthweight in infants born to African HIV-infected women: relationship with maternal body weight during pregnancy: Pregnancy and HIV Study Group (EGE).: Unique Identifier : AIDSLINE MED/99329417; Castetbon K; Ladner J; Leroy V; Chauliac M; Karita E; De Clercq A; Van de Perre P; Dabis F; The effect of maternal HIV infection on birthweight was estimated. In the prenatal clinic of the Centre Hospitalier de Kigali, HIV screening was proposed to women with a gestational age (GA) of less than 28 weeks. HIV-infected (HIV+) and uninfected (HIV-) women were recruited, when they consented. At inclusion, socioe
HIV-related gender biases among malnourished children in Abidjan, Cote D'Ivoire.: J Trop Pediatr. 1999 Jun;45(3):169-71. Unique Identifier : AIDSLINE MED/99329422; Beau JP; Imboua-Coulibaly L; ORSTOM, Abidjan, Cote D'Ivoire.; This study, conducted in a health centre in Abidjan for malnourished children, shows that there were more girls than boys among children admitted who were HIV seropositive whereas there were more boys than girls among seronegative children. Reasons for this gender bias are investigated.
HIV test warning.: JAMA. 1999 Jul 28;282(4):317. Unique Identifier : AIDSLINE MED/99364296
From the Centers for Disease Control and Prevention. Anonymous or confidential HIV counseling and voluntary testing in federally funded testing sites--United States, 1995-1997.: JAMA. 1999 Jul 28;282(4):321-2. Unique Identifier : AIDSLINE MED/99358968
Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study Group [see comments]: JAMA. 1999 Jul 28;282(4):331-40. Unique Identifier : AIDSLINE MED/99358977; Corey L; Langenberg AG; Ashley R; Sekulovich RE; Izu AE; Douglas JM Jr; Handsfield HH; Warren T; Marr L; Tyring S; DiCarlo R; Adimora AA; Leone P; Dekker CL; Burke RL; Leong WP; Straus SE; University of Washington, Seattle, USA.; CONTEXT: In the last 3 decades, herpes simplex virus type 2 (HSV-2) infection seroprevalence and neonatal herpes have increased substantially. An effective vaccine for the prevention of genital herpes could help control this epidemic. OBJECTIVE: To evaluate the efficacy of a vac
Needlestick injuries and subsequent disease: first-person accounts from 3 nurses.: J Emerg Nurs. 1999 Apr;25(2):93-101. Unique Identifier : AIDSLINE MED/99199169; Algie BA; Arnold L; Fowler CL; Retractable Technologies, Inc, Little Elm, Texas, USA.
Gene targeting: applications in transplantation research.: Kidney Int. 1999 Jul;56(1):18-27. Unique Identifier : AIDSLINE MED/99340489; Mannon RB; Coffman TM; Division of Nephrology, Department of Medicine, Duke University; and Veterans Affairs Medical Center, Durham, North Carolina; 27705, USA.; Gene targeting, the manipulation of gene in the mouse genome using homologous recombination in embryonic stem cells, is a powerful experimental tool that has been widely utilized in a number of disciplines. The ability to precisely alter genes in this way provides an avenue for investigating the role of a gene product
Hyperkalemia in patients infected with the human immunodeficiency virus: involvement of a systemic mechanism.: Kidney Int. 1999 Jul;56(1):198-205. Unique Identifier : AIDSLINE MED/99340507; Caramelo C; Bello E; Ruiz E; Rovira A; Gazapo RM; Alcazar JM; Martell N; Ruilope LM; Casado S; Fernandez Guerrero M; Fundacion Jimenez Diaz, Hospital Clinico and Hospital 12 de; Octubre, Universidad Autonoma, Madrid, Spain. ccaramelo@fjd.es; BACKGROUND: The appearance of hyperkalemia has been described in human immunodeficiency virus (HIV)-positive patients treated with drugs with amiloride-like properties. Recent in vitro data suggest that individuals infected with HIV have alterations in transcellular K+ transport. METHODS: With the objective of examini
Monocyte expression of adhesion molecules in HIV-infected patients: variations according to disease stage and possible pathogenic role.: Lab Invest. 1999 Jul;79(7):815-22. Unique Identifier : AIDSLINE MED/99345163; Pillet S; Prevost MH; Preira A; Girard PM; Rogine N; Hakim J; Gougerot-Pocidalo MA; Elbim C; INSERM U 479 and Service d'Immunologie et d'Hematologie, CHU X,; Bichat, Paris, France.; We used flow cytometry to study the expression of adhesion molecules at the cell surface and actin polymerization of whole-blood monocytes in 35 HIV-infected patients at different stages of the disease. Monocytes were activated in vivo, as demonstrated by increased expression of the adhesion molecule CD11b/CD18, reduc
Cyno-EBV (EBV-related herpesvirus from cynomolgus macaques) induces rabbit malignant lymphomas and their tumor cell lines frequently show specific chromosomal abnormalities.: Lab Invest. 1999 Jul;79(7):823-35. Unique Identifier : AIDSLINE MED/99345164; Hayashi K; Chen HL; Yanai H; Koirala TR; Ohara N; Teramoto N; Oka T; Yoshino T; Takahashi K; Miyamoto K; Fujimoto K; Yoshikawa Y; Akagi T; Second Department of Pathology, Okayama University Medical; School, Okayama-city, Japan. kazuhaya@med.okayama-u.ac.jp; Malignant lymphoma (ML) induction in rabbits by Epstein-Barr virus (EBV)-related herpesvirus of cynomolgus (Cyno-EBV) is reported. Twenty-seven of 30 (90%) rabbits inoculated intravenously with Cyno-EBV-producing simian (cynomolgus) lymphocyte cell line (Ts-B6) cells developed ML between 45 and 115 days after inoculat
[Optimization of HIV diagnosis using the RT-PCR (gag) method with various dilutions of cDNA and MgCl2 molarity]: Med Arh. 1999;53(2):73-6. Unique Identifier : AIDSLINE MED/99313818; Subasic D; Konjhodzic R; Seric K; Institut za mikrobiologiju, imunologiju i parazitologiju,; Klinicki centar Univerziteta u Sarajevu.; Lack of optimum conditions for PCR can lead to absence of desired PCR products, undefined multiplication and appearance of unwanted products. So, the use of PCR aiming to generate large amounts of target nucleic acid sequences, may be so called double-edged sword . The important parameters in optimisation of PCR meth
[HHV 6,7 and 8. Recently discovered herpesviruses explain the etiology of well-known diseases]: Lakartidningen. 1999 Jun 30;96(26-27):3161-5. Unique Identifier : AIDSLINE MED/99352774; Bergstrom T; Virologiska laboratoriet, Sahlgrenska; Universitetssjukhuset/Sahlgrenska, Goteborg.; tomas.bergstrom@microbio.gu.se; Three new members of the family of human herpesviruses (HHVs) have been identified in less than a decade, HHV 67 and 8. HHV-6 and HHV-7, both infecting T-lymphocytes and phylogenetically related to cytomegalovirus , were identified as causative agents of exanthema subitum. In additi
Time to genotype for selection of antiretroviral regimens in previously treated patients? [comment]: Lancet. 1999 Jun 26;353(9171):2173-4. Unique Identifier : AIDSLINE MED/99320146; Falloon J; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.
Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial [see comments]: Lancet. 1999 Jun 26;353(9171):2195-9. Unique Identifier : AIDSLINE MED/99320155; Durant J; Clevenbergh P; Halfon P; Delgiudice P; Porsin S; Simonet P; Montagne N; Boucher CA; Schapiro JM; Dellamonica P; Department of Infectious Diseases, Archet Hospital, Nice, France.; BACKGROUND: Growing evidence has linked HIV-1 resistance mutations and drug failure. The use of genotypic-resistance analysis to assist therapeutic decision-making in patients failing therapy has not been investigated. We assessed the virological and immunological impact of genotypic-resistance testing. METHODS: We di
Sex education is key to combatting AIDS in Brazil [news]: Lancet. 1999 Jun 26;353(9171):2221. Unique Identifier : AIDSLINE MED/99320169; Csillag C
Prevention of vertical HIV-1 transmission [letter]: Lancet. 1999 Jun 26;353(9171):2240. Unique Identifier : AIDSLINE MED/99320175; Skinner J; Turner MJ
Prevention of vertical HIV-1 transmission [letter]: Lancet. 1999 Jun 26;353(9171):2240-1. Unique Identifier : AIDSLINE MED/99320176; Anderson JR; Hanna G; Gurewitsch E
Prevention of vertical HIV-1 transmission [letter]: Lancet. 1999 Jun 26;353(9171):2241. Unique Identifier : AIDSLINE MED/99320177; Shields JW
Making AIDS a business imperative [editorial]: Lancet. 1999 Jul 3;354(9172):1. Unique Identifier : AIDSLINE MED/99332985
HIV infection: where have all the T cells gone?: Lancet. 1999 Jul 3;354(9172):5-7. Unique Identifier : AIDSLINE MED/99332989; Rowland-Jones S; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, UK.
Home HIV kits unreliable [news]: Lancet. 1999 Jul 3;354(9172):55. Unique Identifier : AIDSLINE MED/99333009
Rapid assessment, injecting drug use, and public health.: Unique Identifier : AIDSLINE MED/99333013; Rhodes T; Stimson GV; Fitch C; Ball A; Renton A; Department of Social Science and Medicine, Imperial College; School of Medicine, University of London, UK. t.rhodes@ic.ac.uk
ApoE genotype and protease-inhibitor-associated hyperlipidaemia [letter]: Lancet. 1999 Jul 3;354(9172):76. Unique Identifier : AIDSLINE MED/99333029; Behrens G; Schmidt HH; Stoll M; Schmidt RE
Immunotherapy with Mycobacterium vaccae in patients with newly diagnosed pulmonary tuberculosis: a randomised controlled trial. Durban Immunotherapy Trial Group [see comments]: Lancet. 1999 Jul 10;354(9173):116-9. Unique Identifier : AIDSLINE MED/99334972; BACKGROUND: Mycobacterium vaccae, an environmental saprophyte, has immunogenic properties that enhance the host immune response. Immunotherapy with M. vaccae has been suggested to shorten short-course antituberculosis chemotherapy. We tested the hypothesis that the addition of M. vaccae to standard short-course antitu
Testing time as resistant HIV-1 faces next wave of attack [news]: Lancet. 1999 Jul 10;354(9173):135. Unique Identifier : AIDSLINE MED/99334984; Mellors J
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load. Pediatric AIDS Clinical Trials Group 076 Study Group [letter]: Lancet. 1999 Jul 10;354(9173):156; discussion 157-8. Unique Identifier : AIDSLINE MED/99334990; Shapiro DE; Sperling RS; Coombs RW
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [letter]: Lancet. 1999 Jul 10;354(9173):156-8. Unique Identifier : AIDSLINE MED/99334991; Wilson D
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [letter]: Lancet. 1999 Jul 10;354(9173):158. Unique Identifier : AIDSLINE MED/99334992; Wolffers I
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [letter]: Lancet. 1999 Jul 10;354(9173):158-9. Unique Identifier : AIDSLINE MED/99334993; Golden B; Cooper E; Cundall D; Moy R
Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation.: Life Sci. 1999;65(4):355-68. Unique Identifier : AIDSLINE MED/99347790; He XH; Shaw PC; Tam SC; Department of Physiology, The Chinese University of Hong Kong,; Shatin, N.T.; PEG modification (PEGylation) has been shown to reduce immunogenicity and prolong circulating half-life of proteins. In the present study, site-directed PEGylation was used to reduce immunogenicity and prolong plasma half-life of trichosanthin (TCS). Four TCS mutants, i.e. S7C, Q219C, K173C and [K173C,Q219C] (KQ), wer
Bio-ethical and legal issues in relation to HIV/AIDS: the Uganda experience.: Med Law. 1998;17(4):619-24. Unique Identifier : AIDSLINE MED/99325244; Yusuf NK; In Uganda , as in many other countries, there is a vacuum regarding an appropriate legal and ethical response to the HIV/AIDS pandemic. Whereas much has been done to address the HIV/AIDS pandemic in a multidisciplinary way, very little has been done regarding legal and ethical issue
Anti-HIV-1 activity of an ionically modified porous polypropylene membrane determined by filtration of a viral suspension.: Microbiol Immunol. 1999;43(2):141-51. Unique Identifier : AIDSLINE MED/99244274; Owada T; Miyashita Y; Motomura T; Onishi M; Yamashita S; Yamamoto N; Department of New Materials Section, Terumo Research and; Development Center, Hadano, Kanagawa, Japan. JZG00166@nifty.ne.jp; We describe here a unique anti-HIV-1 membrane, derived from a chemically modified porous polypropylene (PP) membrane, which lowers viral infectivity upon the filtration of HIV-1 suspension. A cationic polymer, polyethyleneimine (PEI) was graft-polymerized onto the PP filter membrane (PP-PEI), and infectious HIV-1(HTLV
High molecular weight dextran sulfate increases the activity of NF-kappaB-regulated promoter in monocyte-derived macrophages.: Microbiol Immunol. 1999;43(2):187-9. Unique Identifier : AIDSLINE MED/99244281; Jagodzinski PP; Trzeciak WH; Department of Physiological Chemistry, University of Medical; Sciences, Poznan, Poland.; It is known that sulfated polysaccharides can mimic the action of common T-cell mitogens. To investigate the molecular basis of the mitogenic effect of high molecular weight dextran sulfate (HMDS), monocyte-derived macrophages were transfected with recombinant plasmid containing chloramphenicol acetyl transferase (CAT
Denervation enhances spontaneous inflammatory myopathy in SJL mice.: Muscle Nerve. 1999 Jul;22(7):883-8. Unique Identifier : AIDSLINE MED/99326966; Kampman MT; Benestad SL; Fladby T; Maehlen J; Department of Neurology, University Hospital of Tromso, 9038; Tromso, Norway.; We studied the effect of denervation on the spontaneous inflammatory myopathy that occurs in SJL mice. Cryosections from innervated and denervated calf muscles were assessed for severity of inflammation, relative proportions of mononuclear cell subsets, and major histocompatibility complex (MHC) class I expression. A
Case report. Successful therapy of disseminated histoplasmosis in AIDS with liposomal amphotericin B [letter]: Mycoses. 1999 Apr;42(1-2):117-20. Unique Identifier : AIDSLINE MED/99323172; Rieg GK; Shah PM; Helm EB; Just-Nubling G; A 36-year-old HIV-infected male patient presented with relapsing fever episodes to 39 degrees C, night sweats and weight loss. Computerized tomography of the abdomen showed enlarged multiple lymph nodes. After surgical resection of multiple lymph nodes, disseminated infection with Histoplasma capsulatum was diagnosed.
Oropharyngeal candidosis in AIDS patients: an epidemiological study using restriction analysis of Candida albicans total genomic DNA.: Mycoses. 1999 Apr;42(1-2):41-6. Unique Identifier : AIDSLINE MED/99323159; Elias Costa MR; Carnovale S; Relloso MS; Departamento de Microbiologia, Facultad de Medicina, Universidad; de Buenos Aires, Argentina.; This study investigates the epidemiology of Candida albicans strains isolated from oral and rectal swabs obtained before and after treatment with antifungal drugs in hospitalized AIDS patients. Twenty-one health care workers from the hospital unit were also studied. Samples were obtained from the oral cavity and hands
In vitro activity of rilopirox against fluconazole-susceptible and fluconazole-resistant Candida isolates from patients with HIV infection.: Mycoses. 1999 Apr;42(1-2):55-60. Unique Identifier : AIDSLINE MED/99323161; Nenoff P; Taneva E; Pfeil B; Oswald U; Haustein UF; Department of Dermatology, University of Leipzig, Germany.; The in vitro antifungal activity of the new hydroxypyridone antimycotic rilopirox has been evaluated against 38 fluconazole-susceptible and -resistant clinical isolates of Candida albicans together with other Candida species isolated from patients with human immunodeficiency virus (HIV) infection and oropharyngeal can
Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team [see comments]: N Engl J Med. 1999 Aug 5;341(6):385-93. Unique Identifier : AIDSLINE MED/99345285; Mofenson LM; Lambert JS; Stiehm ER; Bethel J; Meyer WA 3rd; Whitehouse J; Moye J Jr; Reichelderfer P; Harris DR; Fowler MG; Mathieson BJ; Nemo GJ; Pediatric, Adolescent and Maternal AIDS Branch, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD, USA. lm65d@nih.gov; BACKGROUND: Maternal, obstetrical, and infant-related factors associated with the risk of perinatal transmission of human immunodeficiency virus type 1 (HIV-1) were identified before the widespread use of zidovudine therapy in pregnant women. The risk factors for transmission when women and infants receive zidovudine
Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group [see comments]: N Engl J Med. 1999 Aug 5;341(6):394-402. Unique Identifier : AIDSLINE MED/99345286; Garcia PM; Kalish LA; Pitt J; Minkoff H; Quinn TC; Burchett SK; Kornegay J; Jackson B; Moye J; Hanson C; Zorrilla C; Lew JF; Department of Obstetrics and Gynecology, Northwestern University,; Chicago, USA. p-garcia@nwu.edu; BACKGROUND: The importance of plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA in pregnant women in relation to the other factors known to influence the risk of transmission of infection to their infants is incompletely defined. We studied the relation of maternal plasma HIV-1 RNA levels to the risk of
Reducing the risk of maternal-infant transmission of HIV by attacking the virus [editorial; comment]: N Engl J Med. 1999 Aug 5;341(6):441-3. Unique Identifier : AIDSLINE MED/99345293; Rogers MF; Shaffer N
Acute renal failure in the course of HIV infection: a single-institution retrospective study of ninety-two patients anad sixty renal biopsies.: Nephrol Dial Transplant. 1999 Jun;14(6):1578-85. Unique Identifier : AIDSLINE MED/99310406; Peraldi MN; Maslo C; Akposso K; Mougenot B; Rondeau E; Sraer JD; Service de Nephrologie A, Hopital Tenon, Paris, France.; BACKGROUND: Acute renal failure syndromes are frequently encountered in patients with human immunodeficiency virus (HIV) infection. Most reported cases of acute renal failure are related to acute tubular necrosis, but many other causes of renal failure have been described in these patients. METHODS: The present work i
Breast-feeding, mastitis, and HIV transmission: nutritional implications.: Nutr Rev. 1999 May;57(5 Pt 1):146-53. Unique Identifier : AIDSLINE MED/99319490; Semba RD; Neville MC; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.; In many developing countries, transmission of the human immunodeficiency virus (HIV) from mother to infant occurs through breast-feeding. Mastitis, an inflammatory process in the breast, may be common in lactating women in Africa and is associated with both higher HIV load in breast milk and mother-to-child transmissi
Evaluation of young children in household contact with adult multidrug-resistant pulmonary tuberculosis cases.: Pediatr Infect Dis J. 1999 Jun;18(6):494-500. Unique Identifier : AIDSLINE MED/99318061; Schaaf HS; Vermeulen HA; Gie RP; Beyers N; Donald PR; Department of Paediatrics and Child Health, Faculty of Medicine,; University of Stellenbosch and Tygerberg Hospital, Western Cape; Province, South Africa.; BACKGROUND: The prevention and management of multidrug-resistant (MDR) tuberculosis has received much attention, but little attention has been given to children with MDR tuberculosis or children in contact with adults with MDR tuberculosis. The aim of this study was to determine the prevalence of tuberculous infection
Effect of changing antiretroviral therapy on human immunodeficiency virus viral load: experience with fifty-four perinatally infected children.: Pediatr Infect Dis J. 1999 Jun;18(6):512-6. Unique Identifier : AIDSLINE MED/99318064; Purswani M; Johann-Liang R; Cervia J; Noel GJ; Department of Pediatrics, The New York Hospital-Cornell Medical; Center, NY, USA.; BACKGROUND: Experience in adults has shown that combination therapy including HIV protease inhibitors (PI) can profoundly affect viral replication and slow progression of HIV-associated disease. Trials defining the i
Spirituality and people with potentially fatal diagnoses.: Nurs Forum. 1999 Jan-Mar;34(1):13-22. Unique Identifier : AIDSLINE MED/99354865; Fryback PB; Reinert BR; College of Nursing, University of Southern Mississippi,; Hattiesburg, USA.; When individuals must deal with potentially fatal diseases their lives change in many ways. This qualitative study was designed to investigate this critical life event. The authors interviewed a convenience sample (N = 15) of 10 women with cancer and 5 men with HIV/AIDS. Findings suggest that spirituality is an essent
[Psoriasis. Clinical cutaneous aspects]: Presse Med. 1999 Jun 26;28(23):1246-50. Unique Identifier : AIDSLINE MED/99349380; Passeron T; Bahadoran P; Lacour JP; Ortonne JP; Service de Dermatologie, Hopital de l'Archet, Nice.; PREDOMINANT FEATURES: Psoriasis is a frequent inflammatory dermatosis. All age groups are involved. The typical lesion is a well-limited erythemato-squamaous non-pruriginous lesion. All skin areas may be involved but each individual has preferential zones. CLINICAL COURSE: This chronic condition progresses by acute fl
The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease.: Proteins. 1999 Aug 1;36(2):147-56. Unique Identifier : AIDSLINE MED/99327013; Todd MJ; Freire E; Department of Biology and Biocalorimetry Center, The Johns; Hopkins University, Baltimore, Maryland 21218, USA.; The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25 degrees C and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 x 10(7 )M-1 and an enthalpy of 7.3 +/- 0.5 kcal/mol, indic
[The number of people in Germany living with HIV infection has reached a new high (news)]: Pharm Unserer Zeit. 1999 May;28(3):158-9. Unique Identifier : AIDSLINE MED/99327665
[AIDS and HIV infections in 1997]: Przegl Epidemiol. 1999;53(1-2):171-9. Unique Identifier : AIDSLINE MED/99331276; Szata W; Zaklad Epidemiologii Panstwowego, Zakladu Higieny, Warszawa.; In Poland 114 AIDS cases and 579 newly discovered HIV infections have been registered in 1997. Annual numbers of diagnosed and notified AIDS cases and HIV infections were rather stable during last years. The nearest future of HIV/AI
[Primary resistance of Mycobacterium tuberculosis in 10 hospitals of the community of Castille and Leon. Group of Microbiologists from Castille and Leon]: Rev Clin Esp. 1999 Mar;199(3):132-5. Unique Identifier : AIDSLINE MED/99246905; Alberte Castineiras A; Perez Pascual P; Servicio de Microbiologia, Hospital del Rio Hortega,; Valladolid.; OBJECTIVE: To determine the primary drug resistance (PDR) of Mycobacterium tuberculosis in ten hospitals in the Castile-Leon Community for a five-year period (1991-1995), in a sanitary area with almost two millions of inhabitants. MATERIAL AND METHODS: The sensitivity of 825 strains of Mycobacterium tuberculosis to an
[Primary cerebral lymphoma associated with AIDS: clinical profile, diagnostic criteria and therapeutic development]: Rev Clin Esp. 1999 Mar;199(3):161-6. Unique Identifier : AIDSLINE MED/99246911; Rubio Rodriguez MC; Rubio Garcia R; Calvo Manuel FA; Instituto Madrileno de Oncologia, Madrid.
[Tests to detect resistance to antiretroviral agents in clinical practice]: Unique Identifier : AIDSLINE MED/99246918; Seriano Vazquez V; Rodriguez-Rosado y Martinez-Echevarria R; Martinez-Echevarria; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
[Reduction of the incidence of tuberculosis following the introduction of new treatments against HIV (letter)]: Rev Clin Esp. 1999 Mar;199(3):186-7. Unique Identifier : AIDSLINE MED/99246921; Castilla Catalan J; Guerra Romero L; Canon Campos J; Noguer Zambrano I; Parras Vazquez F
[Potential opiate withdrawal syndrome after ritonavir administration in a patient treated with methadone (letter)]: Rev Clin Esp. 1999 Mar;199(3):188-9. Unique Identifier : AIDSLINE MED/99246923; Jimenez-Lerma JM; Iraurgi I
[Indinavir-induced anuria (letter)]: Rev Clin Esp. 1999 Mar;199(3):189. Unique Identifier : AIDSLINE MED/99246924; Lacambra Calvet C; Eroles Vega G; Plaza Canteli S; Solis Villa J
Prevention of graft versus host disease by inactivation of host antigen-presenting cells.: Science. 1999 Jul 16;285(5426):412-5. Unique Identifier : AIDSLINE MED/99340301; Shlomchik WD; Couzens MS; Tang CB; McNiff J; Robert ME; Liu J; Shlomchik MJ; Emerson SG; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia, PA 19104, USA.; Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine allogeneic bone marrow transplantation model it was found that,
Demograghic and socio-economic determinants of community and hospital services costs for people with HIV/AIDS in London.: Soc Sci Med. 1999 May;48(10):1433-40. Unique Identifier : AIDSLINE MED/99296133; Kupek E; Dooley M; Whitaker L; Petrou S; Renton A; Department of Public Health, Centro de Ciencias de Saude,; Universidade Federal de Santa Catarina, Florianopolis-SC, Brazil.; kupek@cfh.ufsc.br; We examined the influence of demographic, social and economic background of people with HIV/AIDS in London on total community and hospital services costs. This was a retrospective study of community and hospital service use, needs and costs based on structured questionnaires administered by trained interviewers and co
Doing a shotgun: a drug use practice and its relationship to sexual behaviors and infection risk.: Soc Sci Med. 1999 May;48(10):1441-8. Unique Identifier : AIDSLINE MED/99296134; Perlman DC; Henman AR; Kochems L; Paone D; Salomon N; Des Jarlais DC; Beth Israel Medical Center, New York, NY 10003, USA.; perlman@aecom.yu.edu; There has been a rise in the frequency with which inhalational routes such as smoking are used for illicit drug use. A growing population of new inhalational drug users augments the pool of individuals at risk for transition to injection drug use. Further, illicit drug smoking has been implicated in the transmission o
HIV/AIDS in nonurban Alabama: risk activities and access to services among HIV-infected persons.: South Med J. 1999 Jul;92(7):677-83. Unique Identifier : AIDSLINE MED/99341426; Beltrami JF; Vermund SH; Fawal HJ; Moon TD; Von Bargen JC; Holmberg SD; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, GA, USA.; BACKGROUND: Because AIDS is increasing in rural areas and small cities of the United States , we sought to further describe the epidemiology of HIV/AIDS in nonurban Alabama. METHODS: Extensive interviews of HIV-infected residents of Alabama living outside of urban Birmingham were conduc
Manifestations of AIDS in the head and neck.: South Med J. 1999 Jul;92(7):684-97. Unique Identifier : AIDSLINE MED/99341427; Reisacher WR; Finn DG; Stern J; Zeifer B; Cocker R; Department of Otolaryngology, The New York Eye and Ear Infirmary,; NY, USA.; BACKGROUND: A significant number of patients with the acquired immunodeficiency syndrome (AIDS) are initially seen with symptoms related to the head and neck. It is becoming increasingly challenging for clinicians to accurately diagnose new lesions, considering the vast array of manifestations of AIDS in this region a
Learning from success: global priorities for HIV prevention--Thomas Parran Award Lecture.: Sex Transm Dis. 1999 May;26(5):244-9. Unique Identifier : AIDSLINE MED/99264071; Piot P; UNAIDS, Joint United Nations Programme on HIV/AIDS, Geneva,; Switzerland.
Sexual activity, substance use, and HIV/STD knowledge among detained male adolescents with multiple versus first admissions.: Sex Transm Dis. 1999 May;26(5):265-71. Unique Identifier : AIDSLINE MED/99264074; Harwell TS; Trino R; Rudy B; Yorkman S; Gollub EL; Department of Community and Preventive Medicine, Allegheny; University of the Health Sciences, Philadelphia, Pennsylvania,; USA. tharwell@state.mt.us; BACKGROUND: Incarcerated and detained youth are at high risk for sexually transmitted diseases (STD), including human immunodeficiency virus (HIV). GOAL OF THE STUDY: To compare the level of sexual activity and substance use-related risk and knowledge regarding HIV/STD among male adolescents with multiple (YMA) versus
Disclosure of HIV status to sexual partners: predictors and temporal patterns.: Sex Transm Dis. 1999 May;26(5):281-5. Unique Identifier : AIDSLINE MED/99264077; Niccolai LM; Dorst D; Myers L; Kissinger PJ; HIV Outpatient Program, Louisiana State University Medical; Center, New Orleans 70112, USA. Iniccol@mailhost.tcs.tulane.edu; BACKGROUND AND OBJECTIVES: Failure to disclose human immunodeficiency virus (HIV) infection to sexual partners interferes with risk reduction. GOAL OF THIS STUDY: The purpose of this study was to identify factors associated with disclosure and failure to disclose HIV infection to sexual partners and to describe condom
HIV surveillance: a dynamic, not static, process to assure accurate local data.: Sex Transm Dis. 1999 May;26(5):291-5. Unique Identifier : AIDSLINE MED/99264079; Griffin RG; Wilkinson TH; Hoff GL; Kansas City Health Department, Communicable Disease Prevention; Program, Missouri 64108, USA. ron_griffin@kcmo.org; BACKGROUND AND OBJECTIVES: Accurate human immunodeficiency virus (HIV) surveillance data is critical for the allocation of resources for care services and community prevention planning efforts. GOAL OF THIS STUDY: To validate HIV status of women and assess risk factor information on all persons reported with either he
Tuberculosis in AIDS: past or new problems? [editorial]: Thorax. 1999 Jul;54(7):567-71. Unique Identifier : AIDSLINE MED/99307471; Mayaud C; Cadranel J
Episcleritis associated with pigmentary retinal degeneration in an HTLV-I carrier.: Tokai J Exp Clin Med. 1998 Oct;23(4):183-5. Unique Identifier : AIDSLINE MED/99286067; Nomura E; Kimura T; Yabuki K; Kurita M; Goto K; Ohno S; Department of Ophthalmology, Yokohama City University School of; Medicine, Japan.; Human T-cell lymphotropic virus type I (HTLV-I) has been reported as the cause of a kind of endogenous uveitis (HTLV-I associated uveitis; HAU). We observed a case of episcleritis in a HTLV-I carrier with pigmentary retinal degeneration. HTLV-I infection might be associated with the development of episcleritis and pig
High-performance liquid chromatography method for analyzing the antiretroviral agent efavirenz in human plasma.: Ther Drug Monit. 1999 Jun;21(3):346-50. Unique Identifier : AIDSLINE MED/99291773; Villani P; Pregnolato M; Banfo S; Rettani M; Burroni D; Seminari E; Maserati R; Regazzi MB; Department of Pharmacology, IRCCS Policlinico S. Matteo, Italy.; Efavirenz (EFV, DMP-266) is a new antiretroviral agent belonging to the class of nonnucleoside reverse transcriptase inhibitors. It has recently been approved by the Food and Drug Administration in management of human immunodeficiency virus (HIV). Pre
Determination of indinavir, a HIV-1 protease inhibitor, in human plasma using ion-pair reversed-phase high-performance liquid chromatography.: Ther Drug Monit. 1999 Jun;21(3):360-6. Unique Identifier : AIDSLINE MED/99291776; Li W; Coombs RW; Collier AC; Raisys VA; Department of Laboratory Medicine, University of Washington,; Seattle, USA.; Indinavir is widely prescribed as a component of potent antiretroviral therapy for the treatment of HIV-1 infection. Because virologic failure of therapy can result from subtherapeutic drug levels, monitoring of indinavir levels may be important in cl
The fate of donor T-cell receptor transgenic T cells with known host antigen specificity in a graft-versus-host disease model.: Transplantation. 1999 Jul 15;68(1):141-9. Unique Identifier : AIDSLINE MED/99355236; Dey B; Yang YG; Preffer F; Shimizu A; Swenson K; Dombkowski D; Sykes M; Transplantation Biology Research Center/Surgical Service, and; Department of Pathology, Massachusetts General Hospital/Harvard; Medical School, Boston 02129, USA.; BACKGROUND: The expansion of transgenic donor CD8+ T-cells with known allospecificity against a host MHC class I alloantigen was examined in a murine graft-versus-host disease (GVHD) model. METHODS: Lethally irradiated, Ld+ BALB/c mice received bone marrow cells and spleen cells from anti-Ld 2C T-cell receptor (TCR)-t
The effect of methimazole, iodine and splenocytes on thyroid transplants in BB/Wor rats.: Transplantation. 1999 Jul 15;68(1):25-30. Unique Identifier : AIDSLINE MED/99355216; Allen EM; Bartlett ST; Department of Medicine University of Maryland Medical System and; Baltimore VA Medical Center, 21201-1595, USA.; BACKGROUND: BB/Wor rats develop spontaneous autoimmune insulin-requiring diabetes mellitus and lymphocytic thyroiditis (LT). Our investigations examined the effect of the thyroid-specific agents, iodine and methimazole (MMI) on thyroid graft survival in BB/Wor rats, compared the intrathyroidal cytokine mRNA expression
Mechanisms of tolerance induction after intrathymic islet injection: determination of the fate of alloreactive thymocytes.: Transplantation. 1999 Jul 15;68(1):30-9. Unique Identifier : AIDSLINE MED/99355217; Turvey SE; Hara M; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, United Kingdom.; BACKGROUND: Intrathymic (IT) administration of antigen when combined with peripheral T-cell depletion has been shown to induce operational tolerance in a wide range of experimental protocols. IT injection of pancreatic islets has been demonstrated not only to induce tolerance to alloantigen but also to prevent the dev
A case of intestinal Mycobacterium simiae infection in an SIV-infected immunosuppressed rhesus monkey.: Vet Pathol. 1999 May;36(3):249-52. Unique Identifier : AIDSLINE MED/99265237; Didier A; Matz-Rensing K; Kuhn EM; Richter E; Kaup FJ; Abteilung Tiermedizin und Primatenhaltung, Deutsches; Primatenzentrum, Gottingen, Germany. adidier@www.dpz.gwdg.de; Although Mycobacterium simiae was identified and classified more than three decades ago, only a few cases are mentioned in the current literature. After experimental simian immunodeficiency virus infection, a 9-year-old female rhesus monkey (Macaca mulatta) developed progressive immunosuppression and gastrointestinal
Interferon-gamma and interleukin-2 release by lymphocytes derived from the blood, mesenteric lymph nodes and intestines of normal sheep and those affected with paratuberculosis (Johne's disease).: Vet Immunol Immunopathol. 1999 May;68(2-4):139-48. Unique Identifier : AIDSLINE MED/99314910; Burrells C; Clarke CJ; Colston A; Kay JM; Porter J; Little D; Sharp JM; Moredun Research Institute, International Research Centre, Bush; Loan, Penicuik, UK. charles.burrells@cultor.com; This study sought to determine if T-cell cytokine responses to mycobacterial infections in sheep were similar to those in other species and if such responses correlated with prevailing gut pathology. Lymphocytes were isolated from the blood (PBL), mesenteric lymph nodes (MLN) and ileal lamina propria (LPL) of control
Bovine interleukin-12 and modulation of IFNgamma production.: Vet Immunol Immunopathol. 1999 May;68(2-4):193-207. Unique Identifier : AIDSLINE MED/99314916; Collins RA; Howard CJ; Duggan SE; Werling D; Division of Immunology and Pathology, Institute for Animal; Health, Newbury, Berkshire, UK. collinsr@bbsrc.ac.uk; The effects of IL-12 on the responses of cattle peripheral blood mononuclear cells (PBMC) to bovine respiratory syncytial virus (BRSV) antigen and ovalbumin (OVA) were tested, in vitro. IL-12 did not affect the proliferative responses of PBMC to these antigens but markedly accelerated and augmented the level of IFNgam
Up-regulation of tumor necrosis factor alpha mRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection.: Vet Immunol Immunopathol. 1999 May;68(2-4):255-65. Unique Identifier : AIDSLINE MED/99314920; Kabeya H; Ohashi K; Oyunbileg N; Nagaoka Y; Aida Y; Sugimoto C; Yokomizo Y; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Sapporo, Japan.; Protective immune responses were analyzed in eight sheep vaccinated with BLV envelope peptides and experimentally infected with bovine-leukemia virus (BLV). Five of eight peptide-immunized sheep showed a high T-cell proliferative response to the BLV peptides and all of these were protected from the infection. The othe
Safe and effective use of combination antiretroviral treatment.: Acta Clin Belg. 1999 Apr;54(2):55-60. Unique Identifier : AIDSLINE MED/99322945; Colebunders R; Clumeck N; Florence E; Vandercam B; Van Wanzeele F; Van Wijngaerden E; Lacor P; Demonty J; De Wit S; Institute of Tropical Medicine, Department of Clinical Sciences,; Antwerpen, Belgium. bcoleb@itg.be
Belgian consensus recommendations for flow cytometric immunophenotyping. The Belgian Association for Cytometry/Belgische Vereniging voor Cytometrie/Association Belge de Cytometrie.: Acta Clin Belg. 1999 Apr;54(2):88-98. Unique Identifier : AIDSLINE MED/99322950; Van Bockstaele DR; Deneys V; Philippe J; Bernier M; Kestens L; Chatelain B; De Waele M; Demanet C; Universitair Ziekenhuis Antwerpen (UZA/UIA), Laboratorium; Hematologie.; This paper summarises the guidelines and recommendations that were generated during a number of discussion forums attended by the majority of Belgian cytometry laboratory professionals. These forums focused on the rational and optimal use of flow cytometric evaluations in the clinical laboratory setting. The aim was t
Child survival in children born to HIV-2 infected women in Guinea-Bissau, West Africa.: Acta Trop. 1999 Apr 30;72(3):309-15. Unique Identifier : AIDSLINE MED/99247771; Norrgren H; Fonseca A; Andersson S; Dias F; Naucler A; Biberfeld G; National Public Health Laboratory LNSP, Bissau, Guinea-Bissau.; hans.norrgren@infek.lu.se; We have retrospectively studied the effect of maternal HIV-2 infection and other risk factors on child survival at a family planning centre in Bissau, Guinea-Bissau . A total of 2109 women were included, and the seroprevalence of HIV-2 was 5.7%. Overall child mortality of all live
Herbs' benefits and risks [letter]: Am J Nurs. 1999 Jul;99(7):14. Unique Identifier : AIDSLINE MED/99338277; Badten K
Medication compliance [letter]: Am J Nurs. 1999 Jul;99(7):14. Unique Identifier : AIDSLINE MED/99338276; Hall L
We are diminished by one. Just one nurse, with a remarkable dedication.: Am J Nurs. 1999 Jul;99(7):25. Unique Identifier : AIDSLINE MED/99338282; McCabe B; Mount Sinai Medical Center, New York, NY, USA.
[Anonymous serological screening for HIV infection in umbilical cord blood by the pooled-batch system]: An Esp Pediatr. 1999 Jun;50(6):603-6. Unique Identifier : AIDSLINE MED/99338613; Ochoa Sangrador C; Brezmes Valdivieso P; Carrascal Tejado A; Perez Carretero J; Castano Almendral JL; Servicio de Pediatria, Hospital Virgen de la Concha, Zamora.; OBJECTIVE: The aim of this study was to estimate the sero-prevalence of HIV infections in pregnant women of the health area of Zamora, Spain by unlinked anonymous screening and to estimate the percentage of non-diagnosed cases by non-systematic screening. PATIENTS AND METHODS: Umbil
Use of real-time PCR and fluorimetry to detect lamivudine resistance-associated mutations in hepatitis B virus.: Antimicrob Agents Chemother. 1999 Jul;43(7):1600-8. Unique Identifier : AIDSLINE MED/99318585; Cane PA; Cook P; Ratcliffe D; Mutimer D; Pillay D; PHLS Antiviral Susceptibility Reference Unit, Division of; Immunity and Infection, University of Birmingham Medical School,; Birmingham B15 2TT, United Kingdom. p.cane@bham.ac.uk; Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut
Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients.: Antimicrob Agents Chemother. 1999 Jul;43(7):1621-30. Unique Identifier : AIDSLINE MED/99318588; Lopez-Ribot JL; McAtee RK; Perea S; Kirkpatrick WR; Rinaldi MG; Patterson TF; Department of Medicine, The University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78284, USA.; ribot@uthscsa.edu; Mechanisms of resistance to azoles in Candida albicans, the main etiologic agent of oropharyngeal candidiasis (OPC), include alterations in the target enzyme (lanosterol demethylase) and increased efflux of drug. Previous studies on mechanisms of resistance have been limited by the fact that only a single isolate from
Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals.: Antimicrob Agents Chemother. 1999 Jul;43(7):1674-80. Unique Identifier : AIDSLINE MED/99318596; Brindeiro R; Vanderborght B; Caride E; Correa L; Oravec RM; Berro O; Stuyver L; Tanuri A; Departamento de Genetica, Instituto de biologia, Rio de Janeiro,; Brazil.; The presence of human immunodeficiency virus type 1 (HIV-1) bearing mutations resistant to nucleosidic inhibitors of the viral reverse transcriptase (RT) derived from HIV-seropositive asymptomatic and untreated volunteer blood donors was examined. The RT amplicons of 32 specimens were analyzed by using a reverse hybri
Safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus (HIV) type 1 protease inhibitor, following oral administration of single doses to HIV-infected adults.: Antimicrob Agents Chemother. 1999 Jul;43(7):1686-92. Unique Identifier : AIDSLINE MED/99318598; Sadler BM; Hanson CD; Chittick GE; Symonds WT; Roskell NS; Glaxo Wellcome Inc., Research Triangle Park, North Carolina; 27709, USA. bms44974@glaxowellcome.com; We conducted a double-blind, placebo-controlled, parallel, dose-escalation trial to evaluate the pharmacokinetics and safety of single, oral doses of amprenavir (141W94; formerly VX-478), a potent inhibitor of human immunodeficiency virus (HIV) type 1 protease, administered as hard gelatin capsules in 12 HIV-infected
Single-dose pharmacokinetics and safety of abacavir (1592U89), zidovudine, and lamivudine administered alone and in combination in adults with human immunodeficiency virus infection.: Antimicrob Agents Chemother. 1999 Jul;43(7):1708-15. Unique Identifier : AIDSLINE MED/99318602; Wang LH; Chittick GE; McDowell JA; Glaxo Wellcome Inc., Research Triangle Park, North Carolina; 27709, USA.; Abacavir (1592U89), a nucleoside reverse transcriptase inhibitor with in vitro activity against human immunodeficiency virus type-1 (HIV-1), has been evaluated for efficacy and safety in combination regimens with other nucleoside analogs, including zi
Ritonavir-fluoxetine interaction [letter]: Antimicrob Agents Chemother. 1999 Jul;43(7):1815. Unique Identifier : AIDSLINE MED/99364287; Eralp Bellibas S
The S-acyl-2-thioethyl pronucleotide approach applied to acyclovir: part I. Synthesis and in vitro anti-hepatitis B virus activity of bis(S-acyl-2-thioethyl)phosphotriester derivatives of acyclovir.: Antiviral Res. 1999 Jan;40(3):167-78. Unique Identifier : AIDSLINE MED/99149897; Perigaud C; Gosselin G; Girardet JL; Korba BE; Imbach JL; Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite; Montpellier II, France. perigaud@univ-montp2.fr; The synthesis and in vitro anti-hepatitis B virus (HBV) activity of two mononucleoside phosphotriester derivatives of acyclovir incorporating S-acyl-2-thioethyl (SATE) groups are reported. In contrast to the parent nucleoside, the described phosphotriesters emerged as potent and
A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.: Antiviral Res. 1999 Feb;41(1):21-33. Unique Identifier : AIDSLINE MED/99253493; Humphrey RW; Wyvill KM; Nguyen BY; Shay LE; Kohler DR; Steinberg SM; Ueno T; Fukasawa T; Shintani M; Hayashi H; Mitsuya H; Yarchoan R; HIV and AIDS Malignancy Branch, Division of Clinical Sciences,; National Cancer Institute, NIH, Bethesda, MD 20892, USA.; The pharmacokinetics, toxicity, and activity of KNI-272, a transition state inhibitor of HIV-1 protease, was assessed in a phase I trial. After an initial phase in which the pharmacokinetics were assessed, 37 patients with AIDS or symptomatic HIV infection and 100-400 CD4 cells/mm3 were entered in an escalating dose s
A combinatorial ledge: reverse transcriptase fidelity, total body viral burden, and the implications of multiple-drug HIV therapy for the evolution of antiviral resistance.: Antiviral Res. 1999 Feb;41(1):45-56. Unique Identifier : AIDSLINE MED/99253495; Colgrove R; Japour A; Beth Israel Deaconess Medical Center, Harvard Medical School,; Boston, MA 02215, USA. robin@louis.bidmc.harvard.edu; The chronicity, high mutation rates, and high circulating titers of HIV during the stable phase of infection make rapid evolution of resistance mutations a key predictor of antiretroviral efficacy. Recent advances in measurement of viral RNA titers, turnover dynamics and the in vivo spectrum of resistance mutations
Resistance mutations selected in vivo under therapy with anti-HIV drug HBY 097 differ from resistance pattern selected in vitro.: Antiviral Res. 1999 May;42(1):15-24. Unique Identifier : AIDSLINE MED/99263934; Rubsamen-Waigmann H; Huguenel E; Shah A; Paessens A; Ruoff HJ; von Briesen H; Immelmann A; Dietrich U; Wainberg MA; Bayer Pharma Research Center, Anti-Infectives Research,; Wuppertal, Germany.; The quinoxaline derivative HBY 097, an orally active nonnucleoside inhibitor of HIV-1 reverse transcriptase (NNRTI), showed an efficient suppression of viral load in a dose-escalating phase I study with mean trough concentrations increasing from 137-1299 ug/l [Rubsamen-Waigmann et al., Lancet 349:1517]. Half-maximal i
Antiviral treatment for human immunodeficiency virus patients co-infected with hepatitis B virus: combined effect for both infections, an obtainable goal?: Antiviral Res. 1999 May;42(1):71-6. Unique Identifier : AIDSLINE MED/99263939; Wolters LM; Niesters HG; de Man RA; Schalm SW; Department of Hepatogastroenterology, University Hospital; Rotterdam, The Netherlands.; A large percentage of human immunodeficiency virus (HIV) patients have serological evidence of a past or present hepatitis B virus infection (HBV). Long-term survival is increasing for HIV patients because of highly active antiretroviral therapy. Therefore, the chronic hepatitis B infection may become an important det
Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurina