T-cell function in newborn mice and humans. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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T-cell function in newborn mice and humans.

Immunol Today. 1999 Jul;20(7):330-5. Unique Identifier : AIDSLINE MED/99309061
Adkins B; Dept of Microbiology and Immunology, University of Miami Medical; School, Miami, FL 33136, USA. radkins@mednet.med.miami.edu

Abstract: Neonates mount poor immune responses, and it has been assumed that neonatal T cells differ qualitatively from adult T cells. Here, Becky Adkins discusses this issue in the light of recent data indicating that T cells in neonates are developmentally mature in their capacity to mount protective Th1-type and cytotoxic T lymphocyte responses.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Adult Animal Animals, Newborn B-Lymphocytes/IMMUNOLOGY Cell Differentiation Cytokines/BIOSYNTHESIS Fetal Blood/CYTOLOGY/IMMUNOLOGY Human In Vitro Infant, Newborn/*IMMUNOLOGY Mice Models, Biological T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY T-Lymphocytes, Cytotoxic/CYTOLOGY/IMMUNOLOGY Th1 Cells/CYTOLOGY/IMMUNOLOGYKWDjournalarticlereviewreview,tutorialadultanimalanimals,newbornb-lymphocytes/immunologycelldifferentiationcytokines/biosynthesisfetalblood/cytology/immunologyhumaninvitroinfant,newborn/KWDimmunologymicemodels,biologicalt-lymphocytes/cytology/KWDimmunologyt-lymphocytes,cytotoxic/cytology/immunologyth1cells/cytology/immunology
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