Receptor mediated subversion of macrophage cytokine production by intracellular pathogens. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.

Curr Opin Immunol. 1999 Aug;11(4):406-11. Unique Identifier : AIDSLINE MED/99379872
Mosser DM; Karp CL; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; dmmosser@astro.temple.edu

Abstract: Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited by intracellular pathogens of macrophages to inhibit IL-12 production and delay or prevent the development of cell mediated immunity.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Histoplasmosis/IMMUNOLOGY Human HIV Infections/IMMUNOLOGY Infection/*IMMUNOLOGY Interleukin-12/*BIOSYNTHESIS Leishmaniasis/IMMUNOLOGY Macrophages/*IMMUNOLOGY Measles/IMMUNOLOGY Receptors, Immunologic/*PHYSIOLOGYKWDjournalarticlereviewreview,tutorialanimalhistoplasmosis/immunologyhumanhivinfections/immunologyinfection/KWDimmunologyinterleukin-12/KWDbiosynthesisleishmaniasis/immunologymacrophages/KWDimmunologymeasles/immunologyreceptors,immunologic/KWDphysiology
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