Host genetic influences on HIV-1 pathogenesis. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Host genetic influences on HIV-1 pathogenesis.

Curr Opin Immunol. 1999 Aug;11(4):466-74. Unique Identifier : AIDSLINE MED/99379882
Michael NL; Department of Molecular Diagnostics and Pathogenesis, Division of; Retrovirology, Walter Reed Army Institute of Research, 1600 East; Gude Drive, Rockville, MD 20850, USA. nmichael@pasteur.hjf.org

Abstract: Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Acquired Immunodeficiency Syndrome/ETIOLOGY/*GENETICS/ TRANSMISSION Alleles Heterozygote Human *HIV-1 Major Histocompatibility Complex Polymorphism (Genetics) Promoter Regions (Genetics) Receptors, CCR5/GENETICS/PHYSIOLOGY Receptors, CXCR4/GENETICS/PHYSIOLOGY Receptors, HIV/PHYSIOLOGYKWDjournalarticlereviewreview,tutorialacquiredimmunodeficiencysyndrome/etiology/KWDgenetics/transmissionallelesheterozygotehumanKWDhiv-1majorhistocompatibilitycomplexpolymorphism(genetics)promoterregions(genetics)receptors,ccr5/genetics/physiologyreceptors,cxcr4/genetics/physiologyreceptors,hiv/physiology
991130
A99B1127

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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