Transcriptional regulation of T lymphocyte development and function. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Transcriptional regulation of T lymphocyte development and function.

Annu Rev Immunol. 1999;17:149-87. Unique Identifier : AIDSLINE MED/99286808
Kuo CT; Leiden JM; Department of Medicine, University of Chicago, Illinois 60637,; USA.

Abstract: The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors. Since 1988, several families of functionally important T cell transcription factors have been identified. These include the Ikaros, LKLF, and GATA3 zinc-finger proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4. In this review, we summarize our current understanding of the transcriptional regulation of T cell development and function with particular emphasis on the results of recent gene targeting and transgenic experiments. In addition to increasing our understanding of the molecular pathways that regulate T cell development and function, these results have suggested novel targets for genetic and pharmacological manipulation of T cell immunity.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC Animal Base Sequence Cell Differentiation DNA/GENETICS/METABOLISM DNA-Binding Proteins/GENETICS/METABOLISM Human Killer Cells, Natural/CYTOLOGY/IMMUNOLOGY/METABOLISM Lymphocyte Transformation Support, U.S. Gov't, P.H.S. T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY/METABOLISM Th1 Cells/IMMUNOLOGY/METABOLISM Th2 Cells/IMMUNOLOGY/METABOLISM Trans-Activators/GENETICS/METABOLISM Transcription Factors/GENETICS/METABOLISM Transcription, GeneticKWDjournalarticlereviewreview,academicanimalbasesequencecelldifferentiationdna/genetics/metabolismdna-bindingproteins/genetics/metabolismhumankillercells,natural/cytology/immunology/metabolismlymphocytetransformationsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/cytology/KWDimmunology/metabolismth1cells/immunology/metabolismth2cells/immunology/metabolismtrans-activators/genetics/metabolismtranscriptionfactors/genetics/metabolismtranscription,genetic
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