Regulation of T cell fate by Notch. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Regulation of T cell fate by Notch.

Annu Rev Immunol. 1999;17:283-95. Unique Identifier : AIDSLINE MED/99286812
Robey E; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA. erobey@uclink4.berkeley.edu

Abstract: The transmembrane receptor Notch participates in diverse cell fate decisions throughout embryonic development. Notch receptors and their ligands are expressed in the mammalian thymus, raising the possibility that Notch could regulate T cell fate decisions. Expression of a constitutively activated form of Notch in developing thymocytes causes thymocytes normally destined for the CD4 lineage to adopt the CD8 lineage instead. This suggests that Notch activity normally acts to direct CD4+CD8+ precursors to the CD8 lineage. The choice between CD4 and CD8 T cell fates is also controlled by MHC recognition during positive selection, implying that recognition of class I or II MHC might regulate Notch signaling. Possible models for the regulation of Notch by MHC recognition during CD4 versus CD8 lineage determination are discussed.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Cell Differentiation CD4-Positive T-Lymphocytes/CYTOLOGY/IMMUNOLOGY CD8-Positive T-Lymphocytes/CYTOLOGY/IMMUNOLOGY Human Membrane Proteins/GENETICS/*IMMUNOLOGY Models, Biological Mutation Receptors, Antigen, T-Cell/METABOLISM Signal Transduction Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CYTOLOGY/*IMMUNOLOGYKWDjournalarticlereviewreview,tutorialanimalcelldifferentiationcd4-positivet-lymphocytes/cytology/immunologycd8-positivet-lymphocytes/cytology/immunologyhumanmembraneproteins/genetics/KWDimmunologymodels,biologicalmutationreceptors,antigen,t-cell/metabolismsignaltransductionsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/cytology/KWDimmunology
991130
A99B1097

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .