Aminooxypentane-RANTES, an inhibitor of R5 human immunodeficiency virus type 1, increases the interferon gamma to interleukin 10 ratio without impairing cellular proliferation.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Aminooxypentane-RANTES, an inhibitor of R5 human immunodeficiency virus type 1, increases the interferon gamma to interleukin 10 ratio without impairing cellular proliferation.

AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):861-7. Unique Identifier : AIDSLINE MED/99335207
Rusconi S; La Seta-Catamancio S; Kurtagic S; Galazzi M; Arienti D; Trabattoni D; Wilken J; Thompson DA; Offord RE; Galli M; Clerici M; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Milan, Italy.; rusconi@imiucca.csi.unimi.it

Abstract: Studies have demonstrated that the beta-chemokines RANTES, MIP-1alpha, and MIP-1beta suppress human immunodeficiency type 1 (HIV-1) replication in vitro. Infection with HIV-1 requires expression of CD4 antigen and the chemokine receptor CXCR4 (X4) or CCR5 (R5) on the surface of target cells. The engagement of these receptors with the viral surface proteins is essential for the membrane fusion process. This study investigated the anti-HIV-1 activity of a derivative of RANTES, the CCR5 antagonist aminooxypentane (AOP)-RANTES, on R5 HIV-1 isolates in peripheral blood mononuclear cells. In drug exposure experiments, AOP-RANTES efficiently inhibited viral replication of HIV-1 R5 strains, with a viral breakthrough observed after the withdrawal of the compound. The HIV-1-specific proliferative capacity was maintained under all conditions when compared with controls. An increase in IFN-gamma production accompanied by a parallel decrease in the generation of IL-10 was observed following the in vitro exposure of cells to AOP-RANTES in the presence of three of four HIV-1 R5 isolates. These experiments confirmed that the chemokine receptor antagonist AOP-RANTES was effective as an inhibitor of HIV-1 R5 strain infectivity in peripheral blood mononuclear cells. The capacity of this compound to maintain HIV-1-specific proliferative activity with a shift toward a type 1 cytokine profile makes this compound a unique molecule, one adopting an immunological pathway to limit HIV-1 infection.

Keywords: JOURNAL ARTICLE Anti-HIV Agents/*PHARMACOLOGY Cell Division/DRUG EFFECTS Human HIV-1/*DRUG EFFECTS Interferon Type II/*BIOSYNTHESIS Interleukin-10/*BIOSYNTHESIS RANTES/*ANALOGS & DERIVATIVES/PHARMACOLOGY Support, Non-U.S. Gov't Time Factors
991130
A99B1088

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