MN and IIIB recombinant glycoprotein 120 vaccine-induced binding antibodies to native envelope glycoprotein of human immunodeficiency virus type 1 primary isolates. National Institute of Allergy and Infectious Disease Aids Vaccine Evaluation Group.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):921-30. Unique Identifier : AIDSLINE MED/99335214
Gorse GJ; Patel GB; Mandava M; Berman PW; Belshe RB; St. Louis Department of Veterans Affairs Medical Center and Saint; Louis University School of Medicine, Missouri 63110, USA.; gorsegi@slu.edu

Abstract: The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines to bind to oligomeric native HIV-1 envelope glycoproteins of primary isolates of HIV-1 was measured by flow cytometric indirect immunofluorescence assay (FIFA) in 25 uninfected, healthy adults. After three immunizations, MN rgp120 HIV-1 vaccine given alone and coadministered with IIIB rgp120 HIV-1 vaccine elicited antibody that bound to cells infected with each of a panel of six subtype B strains of HIV-1. Lower levels of vaccine-induced binding antibody were detected against envelope subtype A, D, and (EA) strains of HIV-1 than against subtype B strains. Priming immunization with IIIB rgp120 HIV-1 vaccine alone induced low levels of antibody capable of binding to envelope glycoprotein of primary isolate strains of HIV-1, and booster immunizations with MN rgp120 HIV-1 vaccine resulted in much higher antibody levels. We conclude that MN rgp120 HIV-1 vaccine was an effective inducer of antibody to native envelope glycoproteins of antigenically diverse primary isolates of HIV-1.

Keywords: CLINICAL TRIAL CLINICAL TRIAL, PHASE I JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIAL Adolescence Adult Animal AIDS Vaccines/*IMMUNOLOGY CHO Cells Hamsters Human HIV Antibodies/BLOOD/*IMMUNOLOGY HIV Envelope Protein gp120/*IMMUNOLOGY HIV-1/*IMMUNOLOGY/ISOLATION & PURIF Middle Age Support, U.S. Gov't, P.H.S. Vaccination Vaccines, Synthetic/*IMMUNOLOGY
991130
A99B1081

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