Cytokines and bullous pemphigoid. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Cytokines and bullous pemphigoid.

Eur Cytokine Netw. 1999 Jun;10(2):123-34. Unique Identifier : AIDSLINE MED/99328718
D'Auria L; Fei PC; Ameglio F; Istituto S.-Gallicano, Via S. Gallicano 25/A, 00153 Roma, Italy.

Abstract: This report reviews the data presented in the literature concerning the presence and levels of different cytokines in sera, lesional tissue or blister fluids of patients with bullous pemphigoid. The list of cytokines analysed includes 21 molecules: interleukins (IL)-1 => 8, IL-10 => 13, IL-15, granulocyte-monocyte-colony stimulating factor (GM-CSF), interferon-gamma (IFN-gamma), oncostatin-M (OSM), regulated upon activation normal T cell expressed and presumably secreted (RANTES), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF). Basic information regarding the functions of these cytokines and their possible involvement in the pathogenetic steps of the disease, such as autoantigen expression, autoantibody induction, complement activation, local cell recruitment and stimulation, resident cell activation, release of various effector molecules and tissue damage are also reported. A specific function for each cytokine in bullous pemphigoid induction cannot be still defined, however, the literature attributes a major role to IL-1, IL-4, IL-5, IL-6, IL-8 and IFN-gamma. On the basis of significant (direct or inverse) correlations found between disease intensity and the blister fluid/serum levels, the following cytokines IL-7, IL-15, RANTES, VEGF and TNF-alpha, besides those previously mentioned, may also be involved in this disease.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Autoimmune Diseases/BLOOD/*PHYSIOPATHOLOGY Cytokines/*PHYSIOLOGY Growth Substances/PHYSIOLOGY Hematopoietic Cell Growth Factors/PHYSIOLOGY Human Interleukins/PHYSIOLOGY Mice Mice, Inbred BALB C Pemphigoid, Bullous/BLOOD/*PHYSIOPATHOLOGY Th1 Cells/SECRETION Th2 Cells/SECRETIONKWDjournalarticlereviewreview,tutorialanimalautoimmunediseases/blood/KWDphysiopathologycytokines/KWDphysiologygrowthsubstances/physiologyhematopoieticcellgrowthfactors/physiologyhumaninterleukins/physiologymicemice,inbredbalbcpemphigoid,bullous/blood/KWDphysiopathologyth1cells/secretionth2cells/secretion
991130
A99B1068

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