[Experimental autoimmune uveitis. Characterization of retina infiltrating cells] NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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[Experimental autoimmune uveitis. Characterization of retina infiltrating cells]

Ophthalmologe. 1999 Apr;96(4):252-6. Unique Identifier : AIDSLINE MED/99338008
Zierhut M; Wild U; Roser R; Wiggert B; Thiel HJ; Stiemer R; Abteilung I, Augenklinik der Universitat, Tubingen.

Abstract: The chronic model of murine EAU induced by interphotoreceptor retinoid binding protein represents a disease similar to clinical chorioretinitis. In this study we characterized the kinetics of retina infiltrating T-cells, macrophages and expression of the adhesion molecules ICAM-1 and ICAM-2. METHODS: B10.A mice were immunized subcutaneously with IRBP, and the eyes were analyzed on days 10, 18, 24 and 28. The infiltrating cells were characterized by mAbs recognizing T-cell receptors (TCR) Vss6 and Vss8, T-cell markers, macrophages and ICAM-1 and ICAM-2. RESULTS: While CD8+ T-cells and ICAM-2 were detectable from day 10 (retina is intact) until day 28, CD4+ T-cells, macrophages and ICAM-1 appear with the onset of retinal destruction. Starting at day 10 the dominating TCR was Vss6; Vss8 was noticed from day 18 on. CONCLUSION: CD8+ T-cells infiltrating the intact retina and stimulating the expression of high endothelial venules (HEVs) could be responsible for the onset of uveitis.
Keywords: JOURNAL ARTICLE Retina infiltrierenden Zellen. Acute Disease Animal Antigens, CD/ANALYSIS Autoimmune Diseases/*IMMUNOLOGY Cell Adhesion Molecules/ANALYSIS Chorioretinitis/*IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY English Abstract Female Intercellular Adhesion Molecule-1/ANALYSIS Macrophages/*IMMUNOLOGY Mice Retina/IMMUNOLOGY Retinol-Binding Proteins/IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY Uveitis/*IMMUNOLOGYKWDjournalarticleretinainfiltrierendenzellenKWDacutediseaseanimalantigens,cd/analysisautoimmunediseases/KWDimmunologycelladhesionmolecules/analysischorioretinitis/KWDimmunologycd8-positivet-lymphocytes/immunologyenglishabstractfemaleintercellularadhesionmolecule-1/analysismacrophages/KWDimmunologymiceretina/immunologyretinol-bindingproteins/immunologyt-lymphocytes/KWDimmunologyuveitis/KWDimmunology
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