[Acute hypopyon uveitis with rifabutin therapy of systemic Mycobacterium avium complex (MAC) infection in AIDS] NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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[Acute hypopyon uveitis with rifabutin therapy of systemic Mycobacterium avium complex (MAC) infection in AIDS]

Ophthalmologe. 1999 Apr;96(4):267-9. Unique Identifier : AIDSLINE MED/99338011
Schaller UC; Michl G; Goebel FD; Klauss V; Augenklinik, Universitat Munchen.

Abstract: BACKGROUND: Hypopyon-uveitis has been identified as a dosage-dependent side effect in patients with acquired immunodeficiency syndrome who are treated for Mycobacterium avium complex (MAC) infection with systemic rifabutin. PATIENTS AND METHODS: We report a 38-year-old female AIDS patient with bilateral hypopyon uveitis under therapy with rifabutin in combination with clarithromycin and indinavir. RESULTS: At the time of presentation of the bilateral hypopyon uveitis the patient was treated with rifabutin (300 mg/day), clarithromycin (1000 mg/day) and ethambutol (1000 mg/day) for an M. avium complex infection. Also, the patient received the protease inhibitor indinavir. The rifabutin dose was reduced to 150 mg/day. Hypopyon and inflammation resolved under therapy with steroids. CONCLUSIONS: The concomitant use of rifabutin, clarithromycin, and protease inhibitors may lead to hypopyon uveitis. Reduction of dosage of rifabutin (150 mg/day) and treatment with topical steroids are required.
Keywords: JOURNAL ARTICLE systemischen Mycobacterium avium complex (MAC)-Infektion bei AIDS. Adult AIDS-Related Opportunistic Infections/*DRUG THERAPY Case Report Dose-Response Relationship, Drug Drug Therapy, Combination English Abstract Female Human Iritis/*CHEMICALLY INDUCED/DIAGNOSIS *Mycobacterium avium Complex/DRUG EFFECTS Mycobacterium avium-intracellulare Infection/*DRUG THERAPY Rifabutin/ADMINISTRATION & DOSAGE/*ADVERSE EFFECTS Uveitis, Anterior/*CHEMICALLY INDUCED/DIAGNOSISKWDjournalarticlesystemischenmycobacteriumaviumcomplex(mac)-infektionbeiaidsKWDadultaids-relatedopportunisticinfections/KWDdrugtherapycasereportdose-responserelationship,drugdrugtherapy,combinationenglishabstractfemalehumaniritis/KWDchemicallyinduced/diagnosisKWDmycobacteriumaviumcomplex/drugeffectsmycobacteriumavium-intracellulareinfection/KWDdrugtherapyrifabutin/administration&dosage/KWDadverseeffectsuveitis,anterior/KWDchemicallyinduced/diagnosis
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