Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.
Outcome of multi-drug-resistant tuberculosis in France: a nationwide case-control study.
Am J Respir Crit Care Med. 1999 Aug;160(2):587-93. Unique Identifier : AIDSLINE MED/99359702 Flament-Saillour M; Robert J; Jarlier V; Grosset J; National Reference Center for Surveillance of Mycobacterial; Infections and Their Drug Resistance, Service de; Bacteriologie-Hygiene, Groupe Hospitalier Pitie-Salpetriere,; Paris, France.
Abstract:
The factors related to the outcome of 51 cases of multi-drug-resistant tuberculosis (MDR-TB) reported in 1994 to the French National Reference Center were retrospectively analyzed. The patients (median age, 45 yr) were mainly male (75%), foreign-born (63%), and had pulmonary involvement (95%). Sixteen percent were human immunodeficiency virus (HIV)-coinfected. The number of drugs to which the Mycobacterium tuberculosis isolates were susceptible was four. Only 82% of the patients have been hospitalized at any time (median duration, 33 d). Five patients (9%) received no antituberculosis drugs, although three had drug susceptibility results, indicating that two or more active drugs were available; 46 (91%) received drugs, including 37 who received two or more active drugs. Among the nine cases who received only one active drug, three had drug susceptibility results, indicating that two or more active drugs were available. By December 1996, 10 patients were lost before treatment completion, 24 had treatment failure, and 17 had a favorable outcome. The median survival time was 31 mo. Factors related to a poorer outcome were HIV-coinfection (hazard ratio [HR] = 41), treatment with less than two active drugs (HR = 9.9), and MDR status knowledge at the time of diagnosis (HR = 3.3). The country of birth was not associated with a poorer outcome. The management and outcome of MDR-TB in France has to be improved. A solution would be to develop a specialized unit or team for the treatment of MDR-TB, as recommended by the World Health Organization (WHO).
Keywords: JOURNAL ARTICLE Adult Aged Antitubercular Agents/ADVERSE EFFECTS/*THERAPEUTIC USE AIDS-Related Opportunistic Infections/DIAGNOSIS/*DRUG THERAPY/ MORTALITY Case-Control Studies Female Follow-Up Studies Human Male Microbial Sensitivity Tests Middle Age Mycobacterium tuberculosis/DRUG EFFECTS Patient Care Team Population Surveillance Support, Non-U.S. Gov't Survival Rate Treatment Outcome Tuberculosis, Multidrug-Resistant/DIAGNOSIS/*DRUG THERAPY/ MORTALITY 991130
A99B1050
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Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.
