Sarcoidosis in a patient with AIDS: a manifestation of immune restoration syndrome.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Sarcoidosis in a patient with AIDS: a manifestation of immune restoration syndrome.

J Am Acad Dermatol. 1999 Aug;41(2 Pt 2):285-6. Unique Identifier : AIDSLINE MED/99355863
Mirmirani P; Maurer TA; Herndier B; McGrath M; Weinstein MD; Berger TG; University of California, Department of Dermatology, San; Francisco, CA 94143-0316, USA. paradi@itsa.ucsf.edu

Abstract: Sarcoidosis has been rarely reported in the presence of HIV infection. Helper T-lymphocyte depletion may attenuate granuloma formation. We present a patient who developed active sarcoidosis after being started on highly active antiretroviral therapy (HAART), which increased his CD4 count and decreased his viral load. There have been reports of exaggerated responses to mycobacteria and viruses with the restoration of T-cell function after HAART in HIV-infected patients. We propose that active sarcoidosis seen in this patient is also a manifestation of this newly observed "immune restoration disease."

Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DRUG THERAPY/ IMMUNOLOGY/VIROLOGY Acute Disease Anti-HIV Agents/ADMINISTRATION & DOSAGE Case Report CD4 Lymphocyte Count Human Male Middle Age Sarcoidosis/*COMPLICATIONS/PATHOLOGY Skin/PATHOLOGY Support, U.S. Gov't, P.H.S. Viral Load
991130
A99B0948

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