Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice.

Int J Immunopharmacol. 1999 May;21(5):311-23. Unique Identifier : AIDSLINE MED/99335113
Hasegawa T; Ito K; Ueno S; Kumamoto S; Ando Y; Yamada A; Nomoto K; Yasunobu Y; Research Laboratories, Chlorella Industries Co., Ltd, Chikugo; City, Fukuoka, Japan. hasegawa@chlorella.co.jp

Abstract: Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Thl) responses producing gamma-interferon (gammaIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased gammaIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Thl response to casein in the spleen of casein immunized mice. CVE may be useful for prevention of allergic diseases with a predominant Th2 response.
Keywords: JOURNAL ARTICLE Administration, Oral Animal Biological Response Modifiers/ISOLATION & PURIF/*PHARMACOLOGY Caseins/*IMMUNOLOGY Chlorella/*CHEMISTRY Epitopes/IMMUNOLOGY Female Freund's Adjuvant/PHARMACOLOGY Heat IgE/*BIOSYNTHESIS/BLOOD Interferon Type II/BIOSYNTHESIS Interleukin-12/BIOSYNTHESIS Mice Mice, Inbred DBA RNA, Messenger/BIOSYNTHESIS/METABOLISM Spleen/METABOLISM T-Lymphocytes/METABOLISM Th2 Cells/IMMUNOLOGY/METABOLISM Water/CHEMISTRYKWDjournalarticleadministration,oralanimalbiologicalresponsemodifiers/isolation&purif/KWDpharmacologycaseins/KWDimmunologychlorella/KWDchemistryepitopes/immunologyfemalefreund'sadjuvant/pharmacologyheatige/KWDbiosynthesis/bloodinterferontypeii/biosynthesisinterleukin-12/biosynthesismicemice,inbreddbarna,messenger/biosynthesis/metabolismspleen/metabolismt-lymphocytes/metabolismth2cells/immunology/metabolismwater/chemistry
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