1999

Testing for HIV: current practices in the academic ED.: Am J Emerg Med. 1999 Jul;17(4):354-6. Unique Identifier : AIDSLINE MED/99379501; Wilson SR; Mitchell C; Bradbury DR; Chavez J; Division of Emergency Medicine, Department of Internal Medicine,; University of California, Davis, Sacramento, USA.; The objective of this study was to determine common practices for testing for Human Immunodeficiency Virus (HIV), particularly in patients with other sexually transmitted diseases (STD) in emergency departments (ED) with residency training in Emergency Medicine. Via mail, 112 directors of academic emergency medicine p
Induction of cytotoxic and helper T cell responses by modified simian immunodeficiency virus hypervariable epitope constructs.: Viral Immunol. 1999;12(2):117-29. Unique Identifier : AIDSLINE MED/99339703; Meyer D; Torres JV; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis 95616, USA.; We previously reported the broad humoral immunogenicity of peptides synthesized according to the cumulative variability of an epitope (1,16). These peptides, hypervariable epitope constructs (HECs), are designed to represent the envelope glycoproteins of several isolates of the simian immunodeficiency virus (SIV). Whe
Relationship between immunoclinical status and prevalence of viral sexually transmitted diseases among human immunodeficiency virus-1 seropositive patients in Ghana.: Viral Immunol. 1999;12(2):131-7. Unique Identifier : AIDSLINE MED/99339704; Brandful JA; Apeagyei FA; Ampofo WK; Adu-Sarkodie Y; Ansah JE; Nuvor V; Aidoo S; Ishikawa K; Sata T; Yamamoto N; Yamazaki S; Virology Unit, Noguchi Memorial Institute for Medical Research; (NMIMR), University of Ghana, Legon.; In view of the strong association between the acquired immunodeficiency syndrome (AIDS) and sexually transmitted diseases (STDs), we screened 182 human immunodeficiency virus (HIV)-1 infected patients over a 15-month period for serological markers to previously encountered or current STDs, most of viral etiology. The
Correlation of clinical parameters and immunological function with human immunodeficiency virus plasma viremia in children.: Viral Immunol. 1999;12(2):139-48. Unique Identifier : AIDSLINE MED/99339705; Peters VB; Mayer L; Sperber KE; Department of Pediatrics, Mount Sinai School of Medicine, New; York, New York 10029, USA. Vicki Peters@SMTPLINK.MSSM.EDU; Studies of immune function in human immunodeficiency virus (HIV)-infected children are important, because functional abnormalities can precede CD4+ T-cell loss and are associated with the development of opportunistic and bacterial infections. We sought to correlate clinical parameters and immunological function with H
Atopic disorders: a default pathway in the absence of infection?: Immunol Today. 1999 Jul;20(7):317-22. Unique Identifier : AIDSLINE MED/99309059; Erb KJ; Zentrum fur Infektionsforschung, Universitat Wurzburg,; Rontgenring 11, 97070 Wurzburg, Germany.; klaus.erb@mai.l.uni-wuerzburg.de; Atopic disorders, such as asthma, are increasingly prevalent in the developed world. Recent epidemiological and experimental data suggest that some infectious diseases prevalent in the developing nations can inhibit the development of allergic disorders. Here, Klaus Erb reviews the data and presents a model showing ho
T-cell function in newborn mice and humans.: Immunol Today. 1999 Jul;20(7):330-5. Unique Identifier : AIDSLINE MED/99309061; Adkins B; Dept of Microbiology and Immunology, University of Miami Medical; School, Miami, FL 33136, USA. radkins@mednet.med.miami.edu; Neonates mount poor immune responses, and it has been assumed that neonatal T cells differ qualitatively from adult T cells. Here, Becky Adkins discusses this issue in the light of recent data indicating that T cells in neonates are developmentally mature in their capacity to mount protective Th1-type and cytotoxic T
Granuloma formation and tuberculosis transmission in HIV-infected patients [letter]: Immunol Today. 1999 Jul;20(7):336-7. Unique Identifier : AIDSLINE MED/99309062; Ledru E; Ledru S; Zoubga A
Granulomatous inflammation and transmission of infectious disease [letter]: Immunol Today. 1999 Jul;20(7):337. Unique Identifier : AIDSLINE MED/99309063; Di Perri G; Bonora S; Allegranzi B; Concia E
CD26, let it cut or cut it down.: Immunol Today. 1999 Aug;20(8):367-75. Unique Identifier : AIDSLINE MED/99362422; De Meester I; Korom S; Van Damme J; Scharpe S; Laboratory for Medical Biochemistry, University of Antwerp,; Universiteitsplein 1, B-2610 Wilrijk, Belgium.; idmeest@uia.ua.ac.be; The costimulatory properties of CD26 have been studied extensively and significant progress has been made in unravelling the complex nature of this molecule. Here, we summarize recent findings on molecular and functional characteristics of CD26. We argue that a multidisciplinary approach might reveal the molecular eve
HIV-1 tat: immunosuppression via TGF-beta1 induction [letter]: Immunol Today. 1999 Aug;20(8):384-5. Unique Identifier : AIDSLINE MED/99362425; Reinhold D; Wrenger S; Kahne T; Ansorge S
Increase in the immunogenicity of HIV peptide antigens by chemical linkage to polytuftsin (TKPR40).: DNA Cell Biol. 1999 Aug;18(8):623-30. Unique Identifier : AIDSLINE MED/99392354; Gokulan K; Khare S; Rao DN; Department of Biochemistry, All India Institute of Medical; Sciences, New Delhi. gokulan@abgen.cvm.tamu.edu; The use of synthetic peptide antigens in human prophylaxis still suffers from the very important problem of finding suitable carriers devoid of side effects. A desirable carrier for use in humans would be poorly immunogenic by itself, yet it would enhance the immune response to the peptide antigen. In the study report
Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection.: Curr Opin Immunol. 1999 Aug;11(4):371-9. Unique Identifier : AIDSLINE MED/99379867; Virgin HW; Speck SH; Department of Pathology, Washington University School of; Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.; virgin@immunology.wustl.edu; Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi s sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and
Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.: Curr Opin Immunol. 1999 Aug;11(4):406-11. Unique Identifier : AIDSLINE MED/99379872; Mosser DM; Karp CL; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; dmmosser@astro.temple.edu; Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited
The abnormal gene in X-linked lymphoproliferative syndrome.: Curr Opin Immunol. 1999 Aug;11(4):431-4. Unique Identifier : AIDSLINE MED/99379876; Sullivan JL; Program in Molecular Medicine, University of Massachusetts; Medical School, 373 Plantation Street, Biotech II, Suite 318,; Worcester, MA 01605, USA. John.Sullivan@umassmed.edu; The gene defect responsible for X-linked lymphoproliferative syndrome, SH2D1A (SH2-domain-containing gene 1A), was recently cloned. This gene encodes a small protein of 128 amino acids containing a single SH2 domain, which is thought to play an important role in signal transduction in activated T cells. The definition
HIV recent advances in AIDS research: genetics, molecular biology and immunology [editorial]: Curr Opin Immunol. 1999 Aug;11(4):449-50. Unique Identifier : AIDSLINE MED/99379879; Landau NR
T lymphocyte responses in HIV-1 infection: implications for vaccine development.: Curr Opin Immunol. 1999 Aug;11(4):451-9. Unique Identifier : AIDSLINE MED/99379880; Brander C; Walker BD; Partners AIDS Research Center, Massachusetts General Hospital,; Harvard Medical School, MGH-East, 5th floor, 149 13th Street,; Charlestown, MA 02129, USA. brander@helix.mgh.harvard.edu; Substantial progress has been made over the past year in understanding the cellular immune response in HIV pathogenesis. Cytotoxic T lymphocytes play a critical role in establishing the level of viremia and virus-specific Th cell responses appear to affect the in vivo efficacy of cytotoxic T lymphocytes. Together, the
HIV-1 Tat: coping with negative elongation factors.: Curr Opin Immunol. 1999 Aug;11(4):460-5. Unique Identifier : AIDSLINE MED/99379881; Garber ME; Jones KA; Regulatory Biology Laboratory, The Salk Institute, 10010 North; Torrey Pines Road, La Jolla, CA 92037-1099, USA.; The intrinsic processivity of RNA polymerase II complexes arises from a complex interplay between the recently identified positive transcription elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF (5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole [DRB]-sensitivity-inducing factor) and the
Host genetic influences on HIV-1 pathogenesis.: Curr Opin Immunol. 1999 Aug;11(4):466-74. Unique Identifier : AIDSLINE MED/99379882; Michael NL; Department of Molecular Diagnostics and Pathogenesis, Division of; Retrovirology, Walter Reed Army Institute of Research, 1600 East; Gude Drive, Rockville, MD 20850, USA. nmichael@pasteur.hjf.org; Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implicati
Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy.: AIDS. 1999 May 28;13(8):F59-62. Unique Identifier : AIDSLINE MED/99297577; Harrigan PR; Whaley M; Montaner JS; BC Centre for Excellence in HIV/AIDS, St Paul's Hospital,; Vancouver, Canada.; OBJECTIVE: To determine the rate of plasma HIV-1 RNA rebound in patients stopping highly active antiretroviral therapy (HAART) after achieving undetectable viral load. DESIGN: Sequential plasma HIV RNA levels were measured in six patients during the 21 days following withdrawal from HAART. METHODS: Plasma samples were
Effects of metformin on insulin resistance and central adiposity in patients receiving effective protease inhibitor therapy [letter]: AIDS. 1999 May 28;13(8):1000-2. Unique Identifier : AIDSLINE MED/99297598; Saint-Marc T; Touraine JL
Lamivudine for chronic hepatitis B and HIV co-infection [letter]: AIDS. 1999 May 28;13(8):1002-3. Unique Identifier : AIDSLINE MED/99297599; Carton JA; Maradona JA; Asensi V; Rodriguez M; Martinez A
Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert [letter]: AIDS. 1999 May 28;13(8):1004-5. Unique Identifier : AIDSLINE MED/99297600; Otero MJ; Fuertes A; Sanchez R; Luna G
Decreased needs for hospital care and antibiotics in children with advanced HIV-1 disease after protease inhibitor-containing combination therapy [letter]: AIDS. 1999 May 28;13(8):1005-6. Unique Identifier : AIDSLINE MED/99297601; Canani RB; Spagnuolo MI; Cirillo P; Guarino A
What role does HIV-1 subtype play in transmission and pathogenesis? An epidemiological perspective [editorial]: AIDS. 1999 May 28;13(8):873-81. Unique Identifier : AIDSLINE MED/99401982; Hu DJ; Buve A; Baggs J; van der Groen G; Dondero TJ; Division of HIV/AIDS Prevention, National Center for HIV, STD and; TB Prevention, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA.
Improvement in neutrophil and monocyte function during highly active antiretroviral treatment of HIV-1-infected patients.: AIDS. 1999 May 28;13(8):883-90. Unique Identifier : AIDSLINE MED/99297578; Mastroianni CM; Lichtner M; Mengoni F; D'Agostino C; Forcina G; d'Ettorre G; Santopadre P; Vullo V; Department of Infectious and Tropical Diseases, La Sapienza; University of Rome, Italy. vullo@caspur.it; OBJECTIVE: To investigate the effect of highly active antiretroviral treatment (HAART) on neutrophil and monocyte function in patients with moderately advanced HIV-1 infection. DESIGN: Eighteen HIV-1-infected patients with CD4 T cell counts below 350/microl, no concomitant active infection, and no previous use of
Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection.: AIDS. 1999 May 28;13(8):891-9. Unique Identifier : AIDSLINE MED/99297579; Lieberman J; Trimble LA; Friedman RS; Lisziewicz J; Lori F; Shankar P; Jessen H; The Center for Blood Research, Harvard Medical School, Boston, MA; 02115, USA. lieberman@cbr.med.harvard.edu; OBJECTIVE: CD8 T cells, expressing cell surface molecules distinct from those on resting and naive T cells, are increased in HIV infection. The association of increased CD38 and human leukocyte antigen DR (HLA-DR) CD8 T cells with poor prognosis has suggested that activated CD8 T cells may aggravate HIV infection. We
Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D.: AIDS. 1999 May 28;13(8):901-7. Unique Identifier : AIDSLINE MED/99297580; Alaeus A; Lidman K; Bjorkman A; Giesecke J; Albert J; Division of Infectious Diseases, Danderyd Hospital, Karolinska; Institute, Sweden. annette.alaeus@inf.ds.sll.se; OBJECTIVE: HIV-1 is characterized by a high degree of genetic variation and can be divided into at least 10 distinct genetic subtypes. The purpose of this study was to investigate whether the rate of disease progression shows subtype-specific differences. DESIGN: The investigation was divided into two parts; one study
The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling.: AIDS. 1999 May 28;13(8):909-17. Unique Identifier : AIDSLINE MED/99297581; Blanco J; Jacotot E; Cabrera C; Cardona A; Clotet B; De Clercq E; Este JA; Institut de Recerca de la SIDA-Caixa, Laboratori de; Retrovirologia, Hospital Universitari Germans Trias i Pujol,; Badalona, Catalonia, Spain.; OBJECTIVE: The envelope glycoprotein complex (gp120/gp41)n of HIV-1 is one of the viral products responsible for increased apoptosis in HIV infection. Here the role of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis was investigated. METHODS: Apoptosis occurring in cocultures of chronically HI
Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero.: AIDS. 1999 May 28;13(8):919-25. Unique Identifier : AIDSLINE MED/99297582; Olivero OA; Shearer GM; Chougnet CA; Kovacs AA; Landay AL; Baker R; Stek AM; Khoury MM; Proia LA; Kessler HA; Sha BE; Tarone RE; Poirier MC; Division of Basic Sciences, National Cancer Institute, NIH,; Bethesda, Maryland 20892-4255, USA.; OBJECTIVE: The nucleoside analog 3 -azido-3 -deoxythymidine (ZDV) has widespread clinical use but also is carcinogenic in newborn mice exposed to the drug in utero and becomes incorporated into newborn mouse DNA. This pilot study was designed to determine ZDV incorporation into human blood cell DNA from adults and new
Rapid disease progression in HIV-1 perinatally infected children born to mothers receiving zidovudine monotherapy during pregnancy. The Italian register for HIV Infection in Children.: AIDS. 1999 May 28;13(8):927-33. Unique Identifier : AIDSLINE MED/99297583; OBJECTIVE: To investigate the outcome in children perinatally infected with HIV-1 whose mothers received zidovudine (ZDV) monotherapy in pregnancy. DESIGN: Observational retrospective study of a prospectively recruited cohort. SETTING: Italian Register for HIV Infection in Children. PATIENTS: A group of 216 children p
Dynamics of plasma cytokine levels in patients with advanced HIV infection and active tuberculosis: implications for early recognition of patients with poor response to anti-tuberculosis treatment.: AIDS. 1999 May 28;13(8):935-41. Unique Identifier : AIDSLINE MED/99297584; Hsieh SM; Hung CC; Chen MY; Sheng WH; Chang SC; Department of Internal Medicine, National Taiwan University; Hospital, Taipei.; OBJECTIVE: To examine whether the serial measurement of plasma cytokine levels can assist in the early recognition of AIDS/tuberculosis patients with poor response to anti-tuberculosis treatment. DESIGN: Longitudinal, prospective cohort study. SETTING: A university hospital, the largest centre for HIV/AIDS patients in
Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. EuroSIDA study group.: AIDS. 1999 May 28;13(8):943-50. Unique Identifier : AIDSLINE MED/99297585; Mocroft A; Kirk O; Barton SE; Dietrich M; Proenca R; Colebunders R; Pradier C; dArminio Monforte A; Ledergerber B; Lundgren JD; Royal Free Centre for HIV Medicine and Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, London, UK.; OBJECTIVES: To describe changes in haemoglobin over time and to determine the joint prognostic value of the current haemoglobin, CD4 lymphocyte count and viral load among patients from across Europe. PATIENTS: The analysis included 6725 patients from EuroSIDA, an observational, prospective cohort of patients with HIV
Determinants of sustainable CD4 lymphocyte count increases in response to antiretroviral therapy.: AIDS. 1999 May 28;13(8):951-6. Unique Identifier : AIDSLINE MED/99297586; Staszewski S; Miller V; Sabin C; Schlecht C; Gute P; Stamm S; Leder T; Berger A; Weidemann E; Hill A; Phillips A; Department of Infectious Diseases, Klinikum der Johann Wofgang; Goethe-Universitat, Medizinische Klinik, Germany.; OBJECTIVE: HIV-induced CD4 lymphocyte depletion is partially reversed by antiretroviral therapy but it is unclear if the degree to which the CD4 count rises depends on viral suppression (if so, the extent of viral suppression required to achieve a maximal CD4 count rise), whether the rise is sustainable and whether it
Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone.: AIDS. 1999 May 28;13(8):957-62. Unique Identifier : AIDSLINE MED/99297587; Altice FL; Friedland GH; Cooney EL; Yale University AIDS Program, New Haven, Connecticut 06510-2283,; USA.; BACKGROUND: Pharmacokinetic interactions complicate and potentially compromise the use of antiretroviral and other HIV therapeutic agents in patients with HIV disease. This may be particularly so among those receiving treatment for substance abuse. OBJECTIVE: We describe seven cases of opiate withdrawal among patients
Costs of HIV medical care in the era of highly active antiretroviral therapy.: Unique Identifier : AIDSLINE MED/99297588; Gebo KA; Chaisson RE; Folkemer JG; Bartlett JG; Moore RD; OBJECTIVES: In the USA, Medicaid is the principal payer of the health care costs of patients with HIV infection. We wished to determine how the costs to Medicaid of patients in Maryland infected with HIV have changed in the setting of highly active antiretroviral treatment. DESIGN: Observational cohort study. METHODS:
Gonorrhea incidence and HIV testing and counseling among adolescents and young adults seen at a clinic for sexually transmitted diseases.: AIDS. 1999 May 28;13(8):971-9. Unique Identifier : AIDSLINE MED/99297589; Chamot E; Coughlin SS; Farley TA; Rice JC; School of Public Health and Tropical Medicine, Department of; Biostatistics and Epidemiology, Tulane University, New Orleans,; Louisiana, USA.; OBJECTIVE: To determine whether HIV testing and posttest counseling may be associated with an increase in gonorrhea incidence among adolescents and young adults seen at a clinic for sexually transmitted diseases (STD). DESIGN: A historical cohort study with the collection of longitudinal data on the patients HIV test
Prevalence of primary HIV drug resistance among seroconverters during an explosive outbreak of HIV infection among injecting drug users.: AIDS. 1999 May 28;13(8):981-5. Unique Identifier : AIDSLINE MED/99297590; Alexander CS; Dong W; Schechter MT; O'Shaughnessy MV; Strathdee SA; Mo T; Montaner JS; Harrigan PR; BC Centre for Excellence in HIV/AIDS, St Paul's Hospital,; Vancouver, Canada.; OBJECTIVES: This study examined the frequency of transmission of drug resistant HIV in the population of injecting drug users (IDU) in Vancouver, Canada during a period of particularly high virus transmission. DESIGN: All subjects enrolled in the Vancouver Injection Drug Users Stud
Prevalence of unprotected sex among men with AIDS in Los Angeles County, California 1995-1997.: AIDS. 1999 May 28;13(8):987-90. Unique Identifier : AIDSLINE MED/99297591; Simon PA; Thometz E; Bunch JG; Sorvillo F; Detels R; Kerndt PR; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; OBJECTIVE: To determine the prevalence of unprotected sex among men with AIDS in Los Angeles County. DESIGN: Cross-sectional study. METHODS: All men aged > or = 18 years who were newly reported to the local health department with AIDS and completed a standardized interview between January 1995 and June 1997 were inclu
Reasons for failure of prophylaxis for Pneumocystis carinii pneumonia [letter]: AIDS. 1999 May 28;13(8):991-2. Unique Identifier : AIDSLINE MED/99297592; Edge MD; Rimland D
Detection of multiple drug-resistance-associated pol mutations in cervicovaginal secretions from women largely treated with antiretroviral agents [letter]: AIDS. 1999 May 28;13(8):992-4. Unique Identifier : AIDSLINE MED/99297593; Di Stefano M; Fiore JR; Monno L; Lepera A; Pastore G; Angarano G
Dichotomous effects of macrophage-derived chemokine on HIV infection [letter]: AIDS. 1999 May 28;13(8):994-6. Unique Identifier : AIDSLINE MED/99297594; Moriuchi H; Moriuchi M
HIV-negative infants born to HIV-1 but not HIV-2-positive mothers fail to develop a Bacillus Calmette-Guerin scar [letter]: AIDS. 1999 May 28;13(8):996-8. Unique Identifier : AIDSLINE MED/99297595; Ota MO; O'Donovan D; Marchant A; Yamuah L; Harding E; Jaffar S; McAdam KP; Corrah T; Whittle H
Higher antiviral activity of antiretroviral regimens including protease inhibitors [letter]: AIDS. 1999 May 28;13(8):998-9. Unique Identifier : AIDSLINE MED/99297596; de Mendoza C; Soriano V; Rodriguez-Rosado R; Gonzalez-Lahoz J
Anaphylaxis after rechallenge with abacavir [letter]: AIDS. 1999 May 28;13(8):999-1000. Unique Identifier : AIDSLINE MED/99297597; Walensky RP; Goldberg JH; Daily JP
Transcriptional regulation of T lymphocyte development and function.: Annu Rev Immunol. 1999;17:149-87. Unique Identifier : AIDSLINE MED/99286808; Kuo CT; Leiden JM; Department of Medicine, University of Chicago, Illinois 60637,; USA.; The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors. Since 1988, several families of functionally important T cell transcription factors have been identifie
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens.: Annu Rev Immunol. 1999;17:19-49. Unique Identifier : AIDSLINE MED/99286804; Waldmann TA; Tagaya Y; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland, USA. tawald@helix.nih.gov; Interleukin-15 (IL-15) is a 14- to 15-kDa member of the 4 alpha-helix bundle family of cytokines. IL-15 expression is controlled at the levels of transcription, translation, and intracellular trafficking. In particular, IL-15 protein is posttranscriptionally regulated by multiple controlling elements that impede trans
Immunologic basis of antigen-induced airway hyperresponsiveness.: Annu Rev Immunol. 1999;17:255-81. Unique Identifier : AIDSLINE MED/99286811; Wills-Karp M; Department of Environmental Health Sciences, Johns Hopkins School; of Hygiene and Public Health, Baltimore, Maryland 21205, USA.; MKARP@welchlink.welch.jhu.edu; The incidence, morbidity, and mortality of asthma has increased worldwide over the last two decades. Asthma is a complex inflammatory disease of the lung characterized by variable airflow obstruction, airway hyperresponsiveness (AHR), and airway inflammation. The inflammatory response in the asthmatic lung is characte
Regulation of T cell fate by Notch.: Annu Rev Immunol. 1999;17:283-95. Unique Identifier : AIDSLINE MED/99286812; Robey E; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA. erobey@uclink4.berkeley.edu; The transmembrane receptor Notch participates in diverse cell fate decisions throughout embryonic development. Notch receptors and their ligands are expressed in the mammalian thymus, raising the possibility that Notch could regulate T cell fate decisions. Expression of a constitutively activated form of Notch in deve
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses.: Annu Rev Immunol. 1999;17:51-88. Unique Identifier : AIDSLINE MED/99286805; Yewdell JW; Bennink JR; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892-0440, USA. jyewdell@nih.gov, jbennink@nih.gov; Of the many thousands of peptides encoded by a complex foreign antigen that can potentially be presented to CD8+ T cells (TCD8+), only a small fraction induce measurable responses in association with any given major histocompatibility complex class I allele. To design vaccines that elicit optimal TCD8+ responses, a th
The regulation of CD4 and CD8 coreceptor gene expression during T cell development.: Unique Identifier : AIDSLINE MED/99286819; Ellmeier W; Sawada S; Littman DR; Molecular Pathogenesis Program, Skirball Institute of; Biomolecular Medicine, New York, NY 10016, USA.; The two major subsets of T lymphocytes in the peripheral immune system, the helper and cytotoxic T cells, are defined by their expression of either the CD4 or the CD8 glycoproteins, respectively. Expression of these molecules, which serve as coreceptors by interacting specifically with either MHC class II or class I m
Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissues.: Annu Rev Immunol. 1999;17:625-56. Unique Identifier : AIDSLINE MED/99286822; Haase AT; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA. ashley@lenti.med.umn.edu; Human immunodeficiency virus-1 (HIV-1) is usually transmitted through sexual contact and in the very early stages of infection establishes a persistent infection in lymphatic tissues (LT). Virus is produced and stored at this site in a dynamic process that slowly depletes the immune system of CD4+ T cells, setting the
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.: Annu Rev Immunol. 1999;17:657-700. Unique Identifier : AIDSLINE MED/99286823; Berger EA; Murphy PM; Farber JM; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. Edward_Berger@nih.gov; In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor superfamily, have been identified as the principal coreceptors for T cell line-tropic and macrophage-tropic HIV-1 isolates, res
Modifications of HIV-1 retrovirus-like particles to enhance safety and immunogenicity.: Biologicals. 1998 Dec;26(4):255-65. Unique Identifier : AIDSLINE MED/99331461; Persson RH; Cao SX; Cates G; Yao FL; Klein MH; Rovinski B; Pasteur Merieux Connaught Canada Research Centre.; HIV-1 retrovirus-like particles can be produced in VERO cells that have been transfected with an expression construct encoding HIV-1 structural proteins. The particles are entirely non-infectious although structurally they resemble infectious virus particles. This makes them a promising candidate for use as an HIV-1 v
Virus validation of pH 4-treated human immunoglobulin products produced by the Cohn fractionation process.: Biologicals. 1998 Dec;26(4):267-76. Unique Identifier : AIDSLINE MED/99331462; Bos OJ; Sunye DG; Nieuweboer CE; van Engelenburg FA; Schuitemaker H; Over J; Department of Product and Process Development, CLB, Sanquin Blood; Supply Foundation, The Netherlands.; To assess the virus reducing capacity of Cohn s cold ethanol fractionation process for the production of intravenous (IVIg) and intramuscular (IMIg) immunoglobulin products, and treatment of these products at pH 4, a validation study of virus removal and/or inactivation was performed using both lipid-enveloped viruses
Prevention of anomalous band mobility in A + G sequencing ladders of 3'-end-labeled DNA.: Biotechniques. 1999 Jul;27(1):36-8, 42, 46. Unique Identifier : AIDSLINE MED/99335997; Starrs S; Davies RJ; Queen's University, Belfast, Northern Ireland.
Developing surveillance for HIV transmission and risk behaviours among high-risk groups in a central London health district.: J Public Health Med. 1999 Jun;21(2):208-14. Unique Identifier : AIDSLINE MED/99359210; Nardone A; Mercey D; Johnson AM; McCarthy M; Department of Sexually Transmitted Diseases, University College; London Medical School, Mortimer Market Centre.; BACKGROUND: Our aim was to describe surveillance data on HIV transmission and risk behaviours in Camden and Islington, an inner London health district (population 360 000). This information is required to assess the effectiveness of HIV-AIDS prevention. METHODS: We focused on two groups in the local population most se
Aminooxypentane-RANTES, an inhibitor of R5 human immunodeficiency virus type 1, increases the interferon gamma to interleukin 10 ratio without impairing cellular proliferation.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):861-7. Unique Identifier : AIDSLINE MED/99335207; Rusconi S; La Seta-Catamancio S; Kurtagic S; Galazzi M; Arienti D; Trabattoni D; Wilken J; Thompson DA; Offord RE; Galli M; Clerici M; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Milan, Italy.; rusconi@imiucca.csi.unimi.it; Studies have demonstrated that the beta-chemokines RANTES, MIP-1alpha, and MIP-1beta suppress human immunodeficiency type 1 (HIV-1) replication in vitro. Infection with HIV-1 requires expression of CD4 antigen and the chemokine receptor CXCR4 (X4) or CCR5 (R5) on the surface of target cells. The engagement of these re
Expression of CCR5 is increased in human monocyte-derived macrophages and alveolar macrophages in the course of in vivo and in vitro Mycobacterium tuberculosis infection.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):869-74. Unique Identifier : AIDSLINE MED/99335208; Fraziano M; Cappelli G; Santucci M; Mariani F; Amicosante M; Casarini M; Giosue S; Bisetti A; Colizzi V; Department of Biology, University of Rome Tor Vergata, Rome,; Italy. fraziano@bio.uniroma2.it; Human immunodeficiency virus (HIV) replicates more efficiently in Mycobacterium tuberculosis (MTB)-infected macrophages than in uninfected controls. We investigated whether this may be partly explained by changes in expression of CCR5 in the course of mycobacterial infection, as this molecule has been shown to be a co
Characterization of mother-infant HIV type 1 gag p17 sequences associated with perinatal transmission.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):875-88. Unique Identifier : AIDSLINE +; Hahn T; Matala E; Chappey C; Ahmad N; Department of Microbiology and Immunology, College of Medicine,; The University of Arizona Health Sciences Center, Tucson 85724,; USA.; The gag p17 matrix sequences of human immunodeficiency virus type 1 (HIV-1) from seven infected mother-infant pairs were analyzed after perinatal transmission. The p17 matrix open reading frame was maintained in 143 of the 166 clones analyzed (86.2% frequency of intact p17 open reading frames). The functional domains
Assay of plasma samples representing different HIV-1 genetic subtypes: an evaluation of new versions of the amplicor HIV-1 monitor assay.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):889-94. Unique Identifier : AIDSLINE MED/99335210; Alaeus A; Lilja E; Herman S; Spadoro J; Wang J; Albert J; Department of Medicine, Karolinska Hospital, Karolinska; Institute, Stockholm, Sweden. annette.alaeus@inf.ds.sll.se; Quantification of plasma HIV-1 RNA levels has rapidly become the main tool for monitoring disease progression and treatment. However, some first-generation assays do not accurately quantify all HIV-1 subtypes. This study compares the first-generation and two newer prototype Amplicor HIV-1 Monitor assays (Roche Diagnos
Exclusion of HIV coreceptors CXCR4, CCR5, and CCR3 from the HIV envelope.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):895-7. Unique Identifier : AIDSLINE MED/99335211; Lallos LB; Laal S; Hoxie JA; Zolla-Pazner S; Bandres JC; Research Center for AIDS and HIV Infection, Manhattan VA Medical; Center, New York University Medical School, New York 10010, USA.; Both HIV-1 primary isolates and laboratory strains incorporate cell-derived molecules into their envelopes depending on the host cell in which they are grown. This incorporation is not random and, specifically, HIV-1 has been shown to select against the incorporation into its surface of CD4, its main receptor. In this
Immunological responses to envelope glycoprotein 120 from subtypes of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):899-907. Unique Identifier : AIDSLINE MED/99335212; Gilljam G; Svensson A; Ekstrom A; Wahren B; Swedish Institute for Infectious Disease Control, Karolinska; Institute, Stockholm.; The outer envelope glycoprotein (gp120) from subtypes A-E of HIV-1 was purified using a specific high mannose-binding lectin, Galanthus nivalis agglutinin. All isolates were grown in peripheral blood lymphocyte cells in order to avoid selection in cell lines. A comparison of the reactivities of the envelope proteins w
Influence of amino acid substitutions on antigenicity of immunodominant regions of the HTLV type I envelope surface gylcoprotein: a study using monoclonal antibodies raised against relevant peptides.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):909-20. Unique Identifier : AIDSLINE MED/99335213; Londos-Gagliardi D; Jauvin V; Armengaut MH; Astier-Gin T; Goetz M; Huet S; Guillemain BJ; INSERM, U328, Structures et Fonctions des Retrovirus Humains,; Institute Bergonie, France.; By the use of sera of human T cell leukemia virus type I (HTVL-I)-infected individuals it was shown that amino acid substitutions at positions 192 (proline to serine) and 250 (serine to proline) in major immunodominant regions (175-199 and 239-261) of the surface envelope glycoprotein (gp46) of the virus may influence
MN and IIIB recombinant glycoprotein 120 vaccine-induced binding antibodies to native envelope glycoprotein of human immunodeficiency virus type 1 primary isolates. National Institute of Allergy and Infectious Disease Aids Vaccine Evaluation Group.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):921-30. Unique Identifier : AIDSLINE MED/99335214; Gorse GJ; Patel GB; Mandava M; Berman PW; Belshe RB; St. Louis Department of Veterans Affairs Medical Center and Saint; Louis University School of Medicine, Missouri 63110, USA.; gorsegi@slu.edu; The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines to bind to oligomeric native HIV-1 envelope glycoproteins of primary isolates of HIV-1 was measured by flow cytometric indirect immunofluorescence assay (FIFA) in 25 uninfected, healthy adults
Mutations in CCR5-coding sequences are not associated with SIV carrier status in African nonhuman primates.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):931-9. Unique Identifier : AIDSLINE GENBANK/AF081579; Muller-Trutwin MC; Corbet S; Hansen J; Georges-Courbot MC; Diop O; Rigoulet J; Barre-Sinoussi F; Fomsgaard A; Unite de Biologie des Retrovirus, Institut Pasteur, Paris,; France.; African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain speci
Subtypes of HIV type 1 circulating in India: partial envelope sequences.: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):941-4. Unique Identifier : AIDSLINE GENBANK/AF101126; Maitra A; Singh B; Banu S; Deshpande A; Robbins K; Kalish ML; Broor S; Seth P; Department of Microbiology, All India Institute of Medical; Sciences, New Delhi.
Two alleles for rhesus macaque GPR15 (BOB).: AIDS Res Hum Retroviruses. 1999 Jul 1;15(10):945-7. Unique Identifier : AIDSLINE MED/99335217; Pretet JL; Brussel A; Guillet JG; Butor C; Laboratoire d'Immunologie des Pathologies Infectieuses et; Tumorales, INSERM U445, Institut Cochin de Genetique; Moleculaire, Universite Rene Descartes, Paris, France.
"Lifepoint": a case study in using social science community identification data to guide the implementation of a needle exchange program.: AIDS Educ Prev. 1999 Jun;11(3):187-202. Unique Identifier : AIDSLINE MED/99335768; Somlai AM; Kelly JA; Otto-Salaj L; Nelson D; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin 53226, USA.; The public health benefits of needle exchange programs (NEPs) are well known. NEPs lower risk factors for HIV transmission by providing injection drug users (IDUs) with clean syringes and needles; harm reduction materials; and referrals to drug, sexually transmitted disease, mental health, and medical treatment facili
An evaluation of the use of drama to communicate HIV/AIDS information.: AIDS Educ Prev. 1999 Jun;11(3):203-11. Unique Identifier : AIDSLINE MED/99335769; Valente TW; Bharath U; Department of Population and Family Health Sciences, School of; Hygiene and Public Health, Johns Hopkins University, Baltimore,; MD 21205, USA. tvalente@jhsph.edu; This study evaluated the effectiveness of three dramas created to disseminate HIV/AIDS information. Predrama and postdrama interviews were conducted with a cohort of randomly selected audience members from ten separate performances in Tamil Nadu state, India (N = 93); an interview w
Assisting persons living with HIV/AIDS to return to work: programmatic steps for AIDS service organizations.: AIDS Educ Prev. 1999 Jun;11(3):212-23. Unique Identifier : AIDSLINE MED/99335770; Brooks RA; Klosinski LE; AIDS Project Los Angeles, CA 90028, USA.; The objective of this study was to develop a comprehensive picture of the concerns and needs of persons living with HIV/AIDS who are interested in returning to work. To collect information in this new area, a series of focus groups was conducted with a random sample of clients from AIDS Project Los Angeles who were cu
The importance of AIDS-related knowledge for mid-life and older women.: AIDS Educ Prev. 1999 Jun;11(3):224-31. Unique Identifier : AIDSLINE MED/99335771; Yates ME; Stellato RK; Johannes CB; Avis NE; New England Research Institutes, Watertown, MA 02476, USA.; Although the AIDS epidemic has had a major impact on the lives of women throughout the world, there is little knowledge regarding risk factors, transmission factors, prevention methods, and results of prevention efforts for older women, even though almost 10% of all AIDS cases in the Unite
Amphetamine use and its correlates among youths living with HIV.: AIDS Educ Prev. 1999 Jun;11(3):232-42. Unique Identifier : AIDSLINE MED/99335772; Rotheram-Borus MJ; Mann T; Chabon B; Department of Psychiatry, University of California, Los Angeles,; USA.; Amphetamine use and its correlates are examined among youths living with HIV (YLH) to determine whether its use is associated with increased transmission acts and poor health. Amphetamine use, other HIV-related risk acts, T-cell counts, emotional distress, coping style, and symptoms of HIV are examined in 337 YLH. One
This is my story: a descriptive analysis of a peer education HIV/STD risk reduction program for women living in housing developments.: AIDS Educ Prev. 1999 Jun;11(3):243-61. Unique Identifier : AIDSLINE MED/99335773; Downing M; Knight KR; Vernon KA; Seigel S; Ajaniku I; Acosta PS; Thomas L; Porter S; Department of Obstetrics, Gynecology, and Reproductive Sciences,; University of California-San Francisco 94105, USA.; Descriptive, qualitative data was collected from 30 women who participated in the Centers for Disease Control and Prevention-funded Perinatal HIV Reduction and Education Demonstration Activities (PHREDA) Project. Women were primarily heterosexual, welfare-dependent, African-American mothers. Staff trained women to con
Coping among HIV negative and HIV positive female injection drug users.: AIDS Educ Prev. 1999 Jun;11(3):262-73. Unique Identifier : AIDSLINE MED/99335774; Brook DW; Brook JS; Whiteman M; Roberto J; Masci JR; Amundsen F; de Catalogne J; Department of Community and Preventive Medicine, Mount Sinai; School of Medicine, New York, NY 10029, USA.; The study examined the psychosocial determinants of coping ability in a cohort of 249 HIV positive and HIV negative female injection drug users (IDUs), using a cross-sectional retrospective design. Information collected using a structured questionnaire included data on psychosocial risk and protective factors in the p
Relationship between ambulatory care accessibility and hospitalization for persons with advanced HIV disease.: J Health Care Poor Underserved. 1999 Aug;10(3):313-27. Unique Identifier : AIDSLINE MED/99365783; Laine C; Markson LE; Fanning TR; Turner BJ; Thomas Jefferson University, USA.; Specific features of ambulatory care, such as accessibility, may influence hospital use for patients with HIV infection. To identify clinic features associated with a lower risk of hospitalization, 6,280 New York state Medicaid enrollees diagnosed with AIDS in 1987-1992 and managed by one of 157 surveyed clinics were
Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro.: Autoimmunity. 1999;30(1):1-9. Unique Identifier : AIDSLINE MED/99360471; Guo J; Rapoport B; McLachlan SM; Cedars-Sinai Research Institute and the University of California,; Los Angeles School of Medicine, 90048-1869, USA.; Thyroid-infiltrating lymphocytes spontaneously synthesize IgG class thyroid autoantibodies while blood lymphocytes require activation to produce the same autoantibodies. Surprisingly, the stimulus commonly used to induce autoantibodies by blood lymphocytes, Pokeweed mitogen (PWM), inhibits autoantibody synthesis by th
Cytokines and bullous pemphigoid.: Eur Cytokine Netw. 1999 Jun;10(2):123-34. Unique Identifier : AIDSLINE MED/99328718; D'Auria L; Fei PC; Ameglio F; Istituto S.-Gallicano, Via S. Gallicano 25/A, 00153 Roma, Italy.; This report reviews the data presented in the literature concerning the presence and levels of different cytokines in sera, lesional tissue or blister fluids of patients with bullous pemphigoid. The list of cytokines analysed includes 21 molecules: interleukins (IL)-1 => 8, IL-10 => 13, IL-15, granulocyte-monocyte-col
Infection of mice with Mycobacterium bovis-BCG induces both Th1 and Th2 immune responses in the absence of interferon-gamma signalling.: Eur Cytokine Netw. 1999 Jun;10(2):147-54. Unique Identifier : AIDSLINE MED/99328721; Erb KJ; Kirman J; Delahunt B; Moll H; Le Gros G; Zentrum fur Infektionsforschung, Universitat Wurzburg,; Rontgenring 11, 97070 Wurzburg, Germany.; zinf036@rzroe.uni-wuerzburg.de; A murine pulmonary infection model using Mycobacterium bovis-BCG was used to study the development of Th1 and Th2 type responses in mice lacking a functional IFN-gamma receptor (IFN-gamma R-/-). Strikingly, the IFN-gamma R-/- mice maintained the Th1 response and developed a profound M. bovis-BCG, specific Th2 type imm
Systemic delivery of an adenovirus expressing EBV-derived vIL-10 in mice infected with Schistosoma mansoni or Leishmania amazonensis: controversial effects on the development of pathological parameters.: Unique Identifier : AIDSLINE MED/99328723; Verwaerde C; Thiam K; Delanoye A; Fernandez-Gomez R; D'Halluin J; Auriault C; URA CNRS 1854, Institut Pasteur de Lille, 1, rue du Pr-Calmette,; PO Box 447, 59021 Lille, France.; Claudie.Verwaerde@pasteur-lille.fr; Within the context of microorganism/host interactions, those which last over weeks are expected to be sensitive to more or less sustained and targeted immuno-intervention, such as delivery of cytokines known to operate as down-regulators of acute inflammatory processes. IL-10 has received growing attention as a potent
The frequency of Th2 type cells increases with time on peritoneal dialysis in patients with diabetic nephropathy.: Eur Cytokine Netw. 1999 Jun;10(2):219-26. Unique Identifier : AIDSLINE MED/99328729; Zamauskaite A; Yaqoob MM; Madrigal JA; Cohen SB; The Anthony Nolan Bone Marrow Trust, The Royal Free Hospital,; Pond Street, Hampstead, London, NW3 2QG, United Kingdom.; We have analysed the frequency of cytokine-producing T cells in different dialysis groups (haemodialysis; HD and peritoneal dialysis; PD) over time. Although we saw no difference in type 1 cytokine production ( IL-2 and IFN-gamma) in either dialysis group, there was a c
Hepatitis C virus-associated glomerular disease in patients with human immunodeficiency virus coinfection.: J Am Soc Nephrol. 1999 Jul;10(7):1566-74. Unique Identifier : AIDSLINE MED/99332124; Cheng JT; Anderson HL Jr; Markowitz GS; Appel GB; Pogue VA; D'Agati VD; Department of Medicine at Harlem Hospital Center, New York, New; York 10037, USA. jc31@columbia.edu; Chronic infection with hepatitis C virus (HCV) has been linked to the development of glomerular disease. HCV infection is highly prevalent among intravenous drug users, a population that is also at risk for HIV coinfection. This study reports the clinical-pathologic features and outcome of HCV-associated glomerular di
A review of current literature on epidemiology of immediate glove irritation and latex allergy.: Occup Med (Lond). 1999 Jan;49(1):3-9. Unique Identifier : AIDSLINE MED/99380880; Kujala V; Department of Public Health Science and General Practice,; University of Oulu, Finland. veikko.kujala@oulu.fi; Natural rubber latex (NRL) allergy has attained world-wide importance with the diagnosis of glove hypersensitivity, contact urticaria, rhinitis, conjunctivitis, asthma and anaphylaxis. In the present report, the latest literature of the epidemiology of NRL allergy is reviewed, an account on the incidence of NRL allerg
Needlestick injury in clothing industry workers and the risks of blood-borne infection.: Occup Med (Lond). 1999 Jan;49(1):47-9. Unique Identifier : AIDSLINE MED/99380886; Ind JE; Jeffries DJ; St. Bartholomew's Hospital, London, UK.; This paper identifies the hazard of a hollow needle device used extensively in the clothing industry and assesses the risk of transmission for HIV, Hepatitis B and Hepatitis C. A substantial risk of transmission is suggested and measures have been advised for its control. Occupational Health Physicians are advised to
Antiinfectives update: focus on treatment and prevention of viral and associated infections.: Ann Pharmacother. 1999 May;33(5):607-14. Unique Identifier : AIDSLINE MED/99296317; McNicholl IR; Palmer SM; Ziska DS; Cleary JD; Division of Pharmacy Practice, St. Louis College of Pharmacy, MO,; USA.; OBJECTIVE: To review the clinically significant antiinfectives approved by the Food and Drug Administration ( FDA ) since 1996, with an emphasis on agents used for treatment, prevention, or suppression of infection in immunocompromised individuals. DATA SOURCES: A MEDLINE search coverin
Antiretroviral therapy increases serum concentrations of amiodarone [letter]: Ann Pharmacother. 1999 May;33(5):645-6. Unique Identifier : AIDSLINE MED/99296324; Lohman JJ; Reichert LJ; Degen LP
[Transmission of infectious diseases during imprisonment--results of a study and introduction of a model project for infection prevention in Lower Saxony]: Gesundheitswesen. 1999 Apr;61(4):207-13. Unique Identifier : AIDSLINE MED/99336492; Keppler K; Stover H; Carl von Ossietzky-Universitat, Oldenburg.; The increasing imprisonment rate of drug users is linked to a spread of infectious diseases in prisons (HIV and Hepatitis B and C). Several studies indicate a close correlation of imprisonment and transmission of infectious diseases. An analysis of international studies showed that worldwide in several cases transmiss
[Experimental autoimmune uveitis. Characterization of retina infiltrating cells]: Ophthalmologe. 1999 Apr;96(4):252-6. Unique Identifier : AIDSLINE MED/99338008; Zierhut M; Wild U; Roser R; Wiggert B; Thiel HJ; Stiemer R; Abteilung I, Augenklinik der Universitat, Tubingen.; The chronic model of murine EAU induced by interphotoreceptor retinoid binding protein represents a disease similar to clinical chorioretinitis. In this study we characterized the kinetics of retina infiltrating T-cells, macrophages and expression of the adhesion molecules ICAM-1 and ICAM-2. METHODS: B10.A mice were i
[Acute hypopyon uveitis with rifabutin therapy of systemic Mycobacterium avium complex (MAC) infection in AIDS]: Ophthalmologe. 1999 Apr;96(4):267-9. Unique Identifier : AIDSLINE MED/99338011; Schaller UC; Michl G; Goebel FD; Klauss V; Augenklinik, Universitat Munchen.; BACKGROUND: Hypopyon-uveitis has been identified as a dosage-dependent side effect in patients with acquired immunodeficiency syndrome who are treated for Mycobacterium avium complex (MAC) infection with systemic rifabutin. PATIENTS AND METHODS: We report a 38-year-old female AIDS patient with bilateral hypopyon uveit
Topical CTLA4-Ig suppresses ongoing mucosal immune response in presensitized murine model of allergic rhinitis.: Int Arch Allergy Immunol. 1999 Jul;119(3):197-204. Unique Identifier : AIDSLINE MED/99367829; Sato J; Asakura K; Murakami M; Uede T; Kataura A; Department of Otolaryngology, Sapporo Medical University, School; of Medicine, Hokkaido University, Sapporo, Japan.; Allergic rhinitis is thought to be mediated by CD4+ T cells producing Th2-associated cytokines. Optimal Ag-specific T-cell activation requires the engagement of T-cell receptor with antigen (Ag) in the context of MHC, and the engagement of appropriate costimulatory molecules. One of the most well-characterized costimu
Microbiology confirmatory tests for blood donors.: Blood Rev. 1999 Jun;13(2):91-104. Unique Identifier : AIDSLINE MED/99341911; Dow BC; Scottish National Blood Transfusion Service Microbiology; Reference Unit, Glasgow, UK.; Blood donations collected in Scotland are currently screened for the presence of HBsAg, anti-HIV 1 + 2, anti-HCV and syphilis antibodies. Approximately 1% of all donations are found to repeatedly react to one of these four markers on screening but very few represent true infection. These samples must be sent to the de
DNA vaccines for viral diseases.: Braz J Med Biol Res. 1999 Feb;32(2):215-22. Unique Identifier : AIDSLINE MED/99277105; Donnelly JJ; Ulmer JB; Department of Virus and Cell Biology, Merck Research; Laboratories, West Point, PA, USA. john_donnelly@cc.chiron.com; DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization. Antibody, helper T lymphocyte, and cytotoxic T lymphocyte (CTL) responses have
Management of HIV serodiscordant couples. The clinician point of view.: Contracept Fertil Sex. 1999 Jun;27(6):399-404. Unique Identifier : AIDSLINE MED/99360113; Coll O; Vidal R; Martinez de Tejada B; Ballesca JL; Azulay M; Vanrell JA; Institut de Ginecologia Obstetricia i Neonatologia, Hospital; Clinic, IDIBAPS, Barcelona, Spain.; BACKGROUND: Couples where the male partner is HIV-infected but the female partner is not often express a desire for children. Assisted reproduction techniques (ART) with sperm wash can reduce the risk of acquisition of infection for the woman. The information about the characteristics of such couples coming to these
Peanut allergy: a major public health issue.: Pediatr Allergy Immunol. 1999 Feb;10(1):14-20. Unique Identifier : AIDSLINE MED/99336693; Warner JO; University of Southampton/Southampton General Hospital,; Hampshire, UK.
AIDS-related Pneumocystis carinii pneumonia in the era of adjunctive steroids: implication of BAL neutrophilia.: Am J Respir Crit Care Med. 1999 Aug;160(2):493-9. Unique Identifier : AIDSLINE MED/99359688; Azoulay E; Parrot A; Flahault A; Cesari D; Lecomte I; Roux P; Saidi F; Fartoukh M; Bernaudin JF; Cadranel J; Mayaud C; Service de Pneumologie et Reanimation Respiratoire, Unite de; Biostatistique, INSERM U444, France. Hopital Tenon, Paris,; France. eli.azoulay@sls.ap-hop-paris.fr; Factors predictive of mortality in patients with AIDS and Pneumocystis carinii pneumonia (PCP) were identified before the introduction of adjunctive steroids, but they have not been reevaluated since. Because PCP still occurs in AIDS, remaining fatal in some cases, we conducted a multivariate analysis of factors predi
Outcome of multi-drug-resistant tuberculosis in France: a nationwide case-control study.: Am J Respir Crit Care Med. 1999 Aug;160(2):587-93. Unique Identifier : AIDSLINE MED/99359702; Flament-Saillour M; Robert J; Jarlier V; Grosset J; National Reference Center for Surveillance of Mycobacterial; Infections and Their Drug Resistance, Service de; Bacteriologie-Hygiene, Groupe Hospitalier Pitie-Salpetriere,; Paris, France.; The factors related to the outcome of 51 cases of multi-drug-resistant tuberculosis (MDR-TB) reported in 1994 to the French National Reference Center were retrospectively analyzed. The patients (median age, 45 yr) were mainly male (75%), foreign-born (63%), and had pulmonary involvement (95%). Sixteen percent were hum
CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease.: Am J Respir Crit Care Med. 1999 Aug;160(2):711-7. Unique Identifier : AIDSLINE MED/99359719; Saetta M; Baraldo S; Corbino L; Turato G; Braccioni F; Rea F; Cavallesco G; Tropeano G; Mapp CE; Maestrelli P; Ciaccia A; Fabbri LM; Institute of Occupational Medicine and Department of Thoracic; Surgery, University of Padova, Padova, Italy.; Previous studies have shown an increased number of inflammatory cells and, in particular, CD8+ve cells in the airways of smokers with chronic obstructive pulmonary disease (COPD). In this study we investigated whether a similar inflammatory process is also present in the lungs, and particularly in lung parenchyma and
[Pneumonia due to varicella zoster virus in adults: a review of 13 cases]: Arch Bronconeumol. 1999 Jul-Aug;35(7):357-9. Unique Identifier : AIDSLINE MED/99367989; De la Cruz Moron I; Alfageme Michavila I; Munoz Lucena F; Ramos P; Rojas JL; Garcia Polo C; Seccion de Neumologia, Hospital Universitario de Valme,; Sevilla.; Pneumonia due to varicella-zoster virus is a complication of chickenpox that appears almost solely in adults. The clinical picture ranges from varieties with few symptoms to those with severe respiratory insufficiency. This retrospective study of adult varicella pneumonia cases treated at our hospital over a seven-yea
Ethical considerations in a grounded theory study on the dynamics of hope in HIV-positive adults and their significant others.: Nurs Ethics. 1999 May;6(3):224-39. Unique Identifier : AIDSLINE MED/99384570; Kylma J; Vehvilainen-Julkunen K; Lahdevirta J; Department of Nursing Science, University of Kuopio, Finland.; The purpose of this article is to describe and reflect ethical challenges in a grounded theory study on the dynamics of hope in HIV-positive adults and their significant others. It concentrates on the justification of a research problem, sensitive research and the relationship between the researcher and the participan
[Hepatitis associated with HIV]: Ryoikibetsu Shokogun Shirizu. 1999;(24 Pt 2):117-9. Unique Identifier : AIDSLINE MED/99217210; Nishiyama Y; Miura S; Kugai N; Second Department of Internal Medicine, Natinal Defense Medical; College.
[Pulmonary tuberculosis]: Ryoikibetsu Shokogun Shirizu. 1999;(24 Pt 2):188-91. Unique Identifier : AIDSLINE MED/99217229; Amitani R; Department of Infection and Inflammation, Graduate School of; Medicine, Kyoto University.
[Esophageal candidiasis]: Ryoikibetsu Shokogun Shirizu. 1999;(24 Pt 2):342-4. Unique Identifier : AIDSLINE MED/99217276; Ueda Y; Department of Internal Medicine, Kansai Medical University; Rakusai Newtown Hospital.
[Hepatic cryptococcosis]: Ryoikibetsu Shokogun Shirizu. 1999;(24 Pt 2):361-3. Unique Identifier : AIDSLINE MED/99217281; Kashiwagi S; Department of General Medicine, Faculty of Medicine, Kyushu; University Hospital.
[Pneumocystis carinii pneumonia]: Ryoikibetsu Shokogun Shirizu. 1999;(24 Pt 2):409-11. Unique Identifier : AIDSLINE MED/99217298; Ajisawa A; Department of Infectious Diseases, Tokyo Metropolitan Komagome; Hospital.
[HTLV-I-associated myelopathy]: Ryoikibetsu Shokogun Shirizu. 1999;(24 Pt 2):41-5. Unique Identifier : AIDSLINE MED/99217188; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University.
CD4-positive and CD8-positive cytotoxic T lymphocytes contribute to human papillomavirus type 16 E6 and E7 responses.: Clin Diagn Lab Immunol. 1999 Jul;6(4):494-8. Unique Identifier : AIDSLINE MED/99322322; Nakagawa M; Stites DP; Palefsky JM; Kneass Z; Moscicki AB; Departments of Laboratory Medicine, Schools of Medicine and; Dentistry, University of California at San Francisco, San; Francisco, California 94143, USA. mayumi@pangloss.ucsf.edu; Cytotoxic T-lymphocyte (CTL) responses to E6 and E7 were previously shown to be more commonly detectable in human papillomavirus type 16 (HPV-16)-positive women without squamous intraepithelial neoplasia (SIL) than in HPV-16-positive women with SIL (M. Nakagawa, D. P. Stites, S. Farhat, J. R. Sisler, B. Moss, F. Kong,
Cell surface display of human immunodeficiency virus type 1 gp120 on Escherichia coli by using ice nucleation protein.: Clin Diagn Lab Immunol. 1999 Jul;6(4):499-503. Unique Identifier : AIDSLINE MED/99322323; Kwak YD; Yoo SK; Kim EJ; Department of Biotechnology, College of Engineering and; Bioproduct Research Center, Yonsei University, 134 Shinchon-Dong,; Sudaemun-Ku, Seoul 120-749, Korea.; A new system designed for cell surface display of recombinant proteins on Escherichia coli has been evaluated for expression of eukaryotic viral proteins. Human immunodeficiency virus type 1 (HIV-1) gp120 was fused to the C terminus of ice nucleation protein (INP), an outer membrane protein of Pseudomonas syringae. We
A simple saliva-based test for detecting antibodies to human immunodeficiency virus.: Clin Diagn Lab Immunol. 1999 Jul;6(4):577-80. Unique Identifier : AIDSLINE MED/99322339; Schramm W; Angulo GB; Torres PC; Burgess-Cassler A; Saliva Diagnostic Systems, Inc., Vancouver, Washington 98682,; USA.; This study was performed to determine the feasibility of using saliva as a diagnostic medium for the detection of antibodies to human immunodeficiency virus type 1 (HIV-1) and HIV-2 under nonlaboratory conditions and to evaluate the performance characteristics of such a test. We developed for this purpose a self-conta
Heterophile antibodies to bovine and caprine proteins causing false-positive human immunodeficiency virus type 1 and other enzyme-linked immunosorbent assay results.: Clin Diagn Lab Immunol. 1999 Jul;6(4):615-6. Unique Identifier : AIDSLINE MED/99322346; Willman JH; Martins TB; Jaskowski TD; Hill HR; Litwin CM; Division of Clinical Pathology, Department of Pathology,; University of Utah, ARUP Laboratories and the ARUP Institute for; Clinical and Experimental Pathology, Salt Lake City, Utah 84132,; USA.; Heterophile antibodies are a well-recognized cause of erroneous results in immunoassays. We describe here a 22-month-old child with heterophile antibodies reactive with bovine serum albumin and caprine proteins causing false-positive results to human immunodeficiency virus type 1 and other infectious serology testing.
The quantitative and qualitative defect of CD4+ CD45RO+ memory-type T cells are involved in the abnormality of TH1 immunity in atopic dermatitis patients.: Clin Exp Allergy. 1999 May;29(5):687-94. Unique Identifier : AIDSLINE MED/99248036; Matsuyama T; Urano K; Ohkido M; Ozawa H; Ohta A; Kaneko S; Yahata T; Takita C; Nishimura T; Department of Dermatology,Section of Genetic Engineering,; Research Center for Genetic Engineering and Cell Transplantation,; Bohseidai, Isehara, Japan.; Peripheral blood mononuclear cells (PBMCs) obtained from atopic dermatitis (AD) patients produced low levels of IFN-gamma in response to Dermatophagoides farinae antigen (Der f Ag) plus IL-2 or OKT3 MoAb in contrast with PBMCs obtained from healthy donors. The reduced
Regression of orthotopic brain tumors by cytokine-assisted tumor vaccines primed in the brain.: Cancer Gene Ther. 1999 Jul-Aug;6(4):302-12. Unique Identifier : AIDSLINE MED/99345416; Tseng SH; Hsieh CL; Lin SM; Hwang LH; Department of Surgery, National Taiwan University Hospital,; Taipei, Republic of China.; This study investigated the therapeutic effects of a rat glioma cell line, C6, that was engineered to secrete mouse GM-CSF (mGM-CSF) on intracerebral (i.c.) brain tumors. Significant antitumor immunity was induced in rats when the live or irradiated mGM-CSF-secreting tumor vaccine was implanted i.c. The antitumor acti
The Rev protein is able to transport to the cytoplasm small nucleolar RNAs containing a Rev binding element.: RNA. 1999 Aug;5(8):993-1002. Unique Identifier : AIDSLINE MED/99373046; Buonomo SB; Michienzi A; De Angelis FG; Bozzoni I; Istituto Pasteur, Fondazione Cenci-Bolognetti, Dipartimento di; Genetica e Biologia Molecolare, Universita di Roma La Sapienza,; Italy.; Small nucleolar RNAs (snoRNAs) were utilized to express Rev-binding sequences inside the nucleolus and to test whether they are substrates for Rev binding and transport. We show that U16 snoRNA containing the minimal binding site for Rev stably accumulates inside the nucleolus maintaining the interaction with the basi
Post-exposure prophylaxis: a new form of prevention? [editorial]: Aids Patient Care STDS. 1999 May;13(5):261-3. Unique Identifier : AIDSLINE MED/99285291; Laurence J
Disclosure of HIV status.: Aids Patient Care STDS. 1999 May;13(5):265-7. Unique Identifier : AIDSLINE MED/99285292; Stein MD; Samet JH; Department of Medicine, Brown University School of Medicine,; Providence, Rhode Island, USA.; A significant proportion of HIV-infected persons choose not to disclose their status to sexual partners. Healthcare providers may play a role in motivating patients to disclose despite powerful forces working in favor of secrecy.
Will the immune system ever recover?: Aids Patient Care STDS. 1999 May;13(5):269-72. Unique Identifier : AIDSLINE MED/99285293; Autran B; Laboratoire d'Immunologie Cellulaire, Centre Hospitalier; Universitaire Pitie Salpetriere, Paris, France.; brigitte.autran@psl.ap-hop-paris.fr
Ethical issues in AIDS vaccine development.: Aids Patient Care STDS. 1999 May;13(5):273-80. Unique Identifier : AIDSLINE MED/99285294; Bloom BR; Harvard School of Public Health, Boston, Massachusetts, USA.
An effective AIDS prevention program and why it is not enough.: Aids Patient Care STDS. 1999 May;13(5):281-6. Unique Identifier : AIDSLINE MED/99285295; Mahidol C; Chulabhorn Foundation, Bangkok, Thailand.
Unusual distributions of body fat in AIDS patients: a review of adverse events reported to the Food and Drug Administration.: Aids Patient Care STDS. 1999 May;13(5):287-95. Unique Identifier : AIDSLINE MED/99285296; Mann M; Piazza-Hepp T; Koller E; Struble K; Murray J; Center for Drug Evaluation and Research, Food and Drug; Administration, Rockville, MD, USA. mannm@eder.fda.gov; This report summarizes postmarketing adverse events reported to the Food and Drug Administration ( FDA ) that describe unusual or abnormal fat distribution in association with anti-retroviral therapies. Reports associated will protease in
Boosting social support in caregivers of children with HIV/AIDS.: Aids Patient Care STDS. 1999 May;13(5):297-302. Unique Identifier : AIDSLINE MED/99285297; Hansell PS; Hughes CB; Caliandro G; Russo P; Budin WC; Hartman B; Hernandez OC; College of Nursing, Seton Hall University, South Orange, New; Jersey, USA. hanselph@shu.edu; Providing care for a child that is infected with human immunodeficiency virus (HIV) is challenging for the child s caregiver and affects the entire family system. Research has demonstrated that social support has the potential to buffer caregiver stress and facilitate caregiver coping. A two-group experimental study w
HIV/AIDS case histories: diagnostic problems. Myelodysplasia in AIDS.: Aids Patient Care STDS. 1999 May;13(5):303-5. Unique Identifier : AIDSLINE MED/99285298; Godwin JH; Department of Medicine, New York Presbyterian Hospital-Weill; Medical College of Cornell University, New York, USA.; jgodwin%profsvcs@nyh.med.cornell.edu
Aldesleukin shows promise [news]: Aids Patient Care STDS. 1999 May;13(5):307. Unique Identifier : AIDSLINE MED/99285301
Twice daily saquinavir [news]: Unique Identifier : AIDSLINE MED/99285300
Updated data on amprenavir [news]: Aids Patient Care STDS. 1999 May;13(5):307. Unique Identifier : AIDSLINE MED/99285299
Stopping HAART [news]: Aids Patient Care STDS. 1999 May;13(5):307-8. Unique Identifier : AIDSLINE MED/99285302
New nucleoside analog [news]: Aids Patient Care STDS. 1999 May;13(5):308. Unique Identifier : AIDSLINE MED/99285303
Gel approved for KS [news]: Aids Patient Care STDS. 1999 May;13(5):309. Unique Identifier : AIDSLINE MED/99285304
First AIDS vaccine trial begins in Africa [news]: Aids Patient Care STDS. 1999 May;13(5):309-10. Unique Identifier : AIDSLINE MED/99285305
Clinical trial web site updated [news]: Aids Patient Care STDS. 1999 May;13(5):310. Unique Identifier : AIDSLINE MED/99285306
CDC recommends procedures to reduce spread of TB from HIV-infected prisoners to the community [news]: Aids Patient Care STDS. 1999 May;13(5):312-3. Unique Identifier : AIDSLINE MED/99285309
Measurement of circulating T cell subsets positive for Fas antigen (CD95) in patients with alcoholic hepatitis.: Nihon Arukoru Yakubutsu Igakkai Zasshi. 1999 Jun;34(3):161-72. Unique Identifier : AIDSLINE MED/99352910; Ishimaru H; Department of Internal Medicine, St. Marianna University School; of Medicine, Kawasaki, Japan.; T cell subsets positive for Fas antigen in peripheral blood of patients with alcoholic hepatitis were measured, using monoclonal antibodies in two colour immunofluorescence assay with flowcytometry. 1) In the patients with alcoholic hepatitis, the ratio of mean +/- standard deviation (M +/- SD) of CD4+ cells positive
Ups and downs on the road to an HIV vaccine [news]: Mol Med Today. 1999 Apr;5(4):141-2. Unique Identifier : AIDSLINE MED/99221901; Senior K
New drug makes host cell machinery unavailable to HIV [news]: Mol Med Today. 1999 Jun;5(6):234-5. Unique Identifier : AIDSLINE MED/99296752; Senior K
Clues to common weight disorders from rare lipodystrophies? [news]: Mol Med Today. 1999 Aug;5(8):328. Unique Identifier : AIDSLINE MED/99362830; Dorrell S
CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.: Mol Pathol. 1999 Feb;52(1):32-6. Unique Identifier : AIDSLINE MED/99368710; Kennedy MM; Biddolph S; Lucas SB; Howells DD; Picton S; McGee JO; O'Leary JJ; Nuffield Department of Pathology and Bacteriology, University of; Oxford, UK.; AIMS: Human herpesvirus 8 (HHV-8) is now acknowledged as the infective cofactor in the pathogenesis of Kaposi s sarcoma. The mode by which HHV-8 causes Kaposi s sarcoma is unresolved and it is probable that it acts in conjunction with other factors including cytokines, anti-apoptosis proteins, and cell surface recepto
Enhancing the response to interferon-alpha.: J Clin Virol. 1999 Jun;13(1-2):1-7. Unique Identifier : AIDSLINE MED/99334358; Begemann F; Jablonowski H; I. Medical Department, St. Georg General Hospital, Hamburg,; Germany.; BACKGROUND: Though initially recognized as antiviral agents, it was soon demonstrated that certain neoplasms were particularly sensitive to interferon-alpha (IFN-alpha). Indeed, the initial success of systemic IFN-alpha treatment in AIDS-associated Kaposi s sarcoma (AIDS-KS) occurred before identification of the human
Rapid, phenotypic HIV-1 drug sensitivity assay for protease and reverse transcriptase inhibitors.: J Clin Virol. 1999 Jun;13(1-2):71-80. Unique Identifier : AIDSLINE MED/99334366; Walter H; Schmidt B; Korn K; Vandamme AM; Harrer T; Uberla K; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany.; BACKGROUND: Development of drug resistance is one of the major reasons for the failure of antiretroviral therapy of HIV-1 infection. Knowing the drug sensitivity-resistance profile of viruses present in a patient prior to treatment or change in treatment could help to optimize therapy. OBJECTIVE: Development of a rapi
Perspectives for the treatment of hepatitis B virus infections.: Int J Antimicrob Agents. 1999 Jul;12(2):81-95. Unique Identifier : AIDSLINE MED/99345093; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. erik.declercq@rega.kuleuven.ac.be; Primarily resulting as a spin-off of the search for effective anti-HSV or anti-HIV agents, several compounds have been identified as effective and promising candidate anti-HBV drugs, i.e. famciclovir (penciclovir), BMS-200475, lamivudine ( 3TC ), (-)FTC
HIV and infant feeding: a policy statement developed collaboratively by UNAIDS, WHO and UNICEF, 1997.: Breastfeed Rev. 1999 Jul;7(2):14. Unique Identifier : AIDSLINE MED/99383082
HIV and infant feeding: to breastfeed or not to breastfeed: the dilemma of competing risks. Part 1.: Breastfeed Rev. 1999 Jul;7(2):5-13. Unique Identifier : AIDSLINE MED/99383081; Morrison P; mhc@harare.iafrica.com; The discovery of the human immunodeficiency virus (HIV) in breastmilk in 1985, and subsequent research, supports the hypothesis that breastfeeding provides a route of transmission to the nursing baby. Various routes of infection and relative rates of transmission have been studied in many parts of the world, leading t
PGE2 induces its own secretion in vitro by bovine 270-day placenta but not by 200-day placenta.: Prostaglandins Other Lipid Mediat. 1999 Jun;57(4):189-205. Unique Identifier : AIDSLINE MED/99328664; Weems YS; Lammoglia MA; Lewis AW; Randel RD; Sasser RG; Morita I; Weems CW; Department of Animal Sciences, University of Hawaii, Honolulu; 96822, USA. weems@hawaii.edu; Two separate experiments were conducted to determine whether prostaglandin (PG) E2 stimulates the secretion of progesterone by 270- or 200-day Brahman placentas in vitro. Secretion of progesterone, PGF2alpha, pregnancy specific protein B, or estradiol-17beta by 270-day Brahman placentas was not affected (p > or = 0.05
Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic area.: Med Mycol. 1999 Aug;37(4):245-50. Unique Identifier : AIDSLINE MED/99352454; Ampel NM; Medical and Research Services of the Tucson Veterans Affairs; Medical Center, Department of Medicine of the University of; Arizona College of Medicine 85723, USA. nampel@u.arizona.edu; The prognostic importance of specific and general tests of immune function were examined among a cohort of 170 subjects infected with human immunodeficiency virus type-1 (HIV), living in an area endemic for the fungal infection coccidioidomycosis . Using the proportio
A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase.: Mol Cell. 1999 Jul;4(1):35-43. Unique Identifier : AIDSLINE MED/99374051; Meyer PR; Matsuura SE; Mian AM; So AG; Scott WA; Department of Biochemistry and Molecular Biology, University of; Miami School of Medicine, Florida 33101, USA.; Mutations in HIV-1 reverse transcriptase (RT) give rise to 3 -azido-3 -deoxythymidine ( AZT ) resistance by a mechanism that has not been previously reproduced in vitro. We show that mutant RT has increased ability to remove AZTMP from blocked primers t
Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study.: Unique Identifier : AIDSLINE MED/99380066; Periard D; Telenti A; Sudre P; Cheseaux JJ; Halfon P; Reymond MJ; Marcovina SM; Glauser MP; Nicod P; Darioli R; Mooser V; BACKGROUND: Administration of protease inhibitors (PIs) to HIV-infected individuals has been associated with hyperlipidemia. In this study, we characterized the lipoprotein profile in subjects receiving
AIDS: translating research and practice into policy.: Clin Excell Nurse Pract. 1998 Jul;2(4):239-40. Unique Identifier : AIDSLINE MED/99384480; Pulcini J; Nokes K; Hunter-Bellevue School of Nursing, New York, NY 10010, USA.
Lurkers in the water supply: using the Net to protect HIV-positive persons from cryptosporidiosis.: Clin Excell Nurse Pract. 1998 Jul;2(4):248-9. Unique Identifier : AIDSLINE MED/99384482; Bennett SD; Regional Advisory Council of National Library of Medicine, USA.
What is atopy? Condition, disease or a syndrome?: Curr Probl Dermatol. 1999;28:1-8. Unique Identifier : AIDSLINE MED/99302274; Wuthrich B; Department of Dermatology, University Hospital, Zurich,; Switzerland. wuethric@derm.unizh.ch
Atopic and non-atopic asthma.: Curr Probl Dermatol. 1999;28:129-34. Unique Identifier : AIDSLINE MED/99302290; Frew AJ; Southampton General Hospital, UK. jdl@soton.ac.uk
Perspectives of atopic eczema in the third millennium.: Curr Probl Dermatol. 1999;28:194-204. Unique Identifier : AIDSLINE MED/99302295; Ring J; Department of Dermatology and Allergy Biederstein, Technical; University Munich, Germany.
Atopic and vernal keratoconjunctivitis: a model for studying atopic disease.: Curr Probl Dermatol. 1999;28:88-94. Unique Identifier : AIDSLINE MED/99302285; Bonini S; Lambiase A; Matricardi P; Rasi G; D'Amato M; Bonini S; Institute of Experimental Medicine, Italian National Research; Council, Rome, Italy. se.bonini-CNR@flashnet.it
Sero-prevalence of HIV antibodies in tuberculosis patients in Ile-Ife, Nigeria.: East Afr Med J. 1999 Mar;76(3):127-32. Unique Identifier : AIDSLINE MED/99370698; Onipede AO; Idigbe O; Ako-Nai AK; Omojola O; Oyelese AO; Aboderin AO; Akinosho; Komolafe AO; Wemambu SN; Department of Medical Microbiology, Obafemi Awolowo University; Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.; BACKGROUND: The acquired immunodeficiency syndrome (AIDS) is of major public health concern worldwide more so in sub-Saharan Africa where there is an upsurge in the incidence of the disease. Reports from developed countries have shown that a close link exists between the human immunodeficiency virus (HIV) and pulmonar
Carotenoid status of pregnant women with and without HIV infection in Malawi.: East Afr Med J. 1999 Mar;76(3):133-7. Unique Identifier : AIDSLINE MED/99370699; Lan Y; Kumwenda N; Taha TE; Chiphangwi JD; Miotti PG; Mtimavalye L; Broadhead R; van der Hoeven L; Hoover DR; Semba RD; Deparment of Opthalmology, School of Medicine, Johns Hopkins; University Baltimore, Maryland, USA.; OBJECTIVE: To characterise the major plasma carotenoids in pregnant women with and without HIV infection attending antenatal clinic in Blantyre, Malawi . DESIGN: A cross sectional study. SETTING: Antenatal clinic of Queen Elizabeth Central Hospital, Blantyre, Malawi. SUBJECTS: Nine
Prevalence of transfusion-associated viral infections and syphilis among blood donors in Muhimbili Medical Centre, Dar es Salaam, Tanzania.: East Afr Med J. 1999 Mar;76(3):167-71. Unique Identifier : AIDSLINE MED/99370707; Matee MI; Lyamuya EF; Mbena EC; Magessa PM; Sufi J; Marwa GJ; Mwasulama OJ; Mbwana J; Department of Microbiology and Immunology, Faculty of Medicine,; Muhimbili University College of Health Sciences, Dar es Salaam,; Tanzania.; OBJECTIVE: To determine the seroprevalence of the main transfusion-associated viral infections and syphilis among blood donors in Muhimbili Medical Centre, Dar es salaam, Tanzania . DESIGN: Cross sectional study. SETTING: The blood bank unit of Muhimbili Medical Centre in Dar es s
HIV-associated lymphoma: report of three cases.: East Afr Med J. 1999 Mar;76(3):176-7. Unique Identifier : AIDSLINE MED/99370709; Mwangi JW; Department of Haematology and Blood Transfusion, College of; Health Sciences, University of Nairobi.; Persons with congenital or acquired immunosuppression have long been known to have an increased incidence of lymphoproliferative disorders. Unsurprisingly, therefore, the acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), is associated with an increased incidence of lymphoma.
A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.: Unique Identifier : AIDSLINE MED/99321756; Parada CA; Roeder RG; The HIV-1-encoded Tat protein controls transcription elongation by increasing processivity of RNA polymerase II (Pol II). Here, we have identified a Tat stimulatory activity (Tat-SF) as a novel RNA Pol II-containing complex. Remarkably, Tat-SF contains the previously identified Tat cofactors Tat-SF1, P-TEFb and hSPT5/
Assaying RNA chaperone activity in vivo using a novel RNA folding trap.: EMBO J. 1999 Jul 1;18(13):3776-82. Unique Identifier : AIDSLINE MED/99321764; Clodi E; Semrad K; Schroeder R; Institute of Microbiology and Genetics, Vienna Biocenter, Dr; Bohrgasse 9, A-1030 Vienna, Austria.; In the absence of proteins, RNAs often misfold in vitro due to alternative base pairings which result from the molecule being trapped in inactive conformations. We identify an in vivo folding trap in the T4 phage td gene, caused by nine base pairs between a sequence element in the upstream exon of the td gene and anot
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing.: EMBO J. 1999 Jul 15;18(14):4060-7. Unique Identifier : AIDSLINE MED/99335477; Caputi M; Mayeda A; Krainer AR; Zahler AM; Department of Biology and Center for Molecular Biology of RNA,; Sinsheimer Laboratories, University of California Santa Cruz,; Santa Cruz, CA 95064, USA.; Splicing of the human immunodeficiency virus type 1 (HIV-1) pre-mRNA must be inefficient to provide a pool of unspliced messages which encode viral proteins and serve as genomes for new virions. Negative cis-regulatory elements (exonic splicing silencers or ESSs) are necessary for HIV-1 splicing inhibition. We demonst
Comparison of three different commercial methods for measuring plasma viraemia in patients infected with non-B HIV-1 subtypes.: Unique Identifier : AIDSLINE MED/99311739; Holguin A; de Mendoza C; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.; In order to determine whether commercial assays presently in use for the quantification of plasma human immunodeficiency virus type 1 (HIV-1) RNA levels detect different genetic viral subtypes with the same reliability, a panel of 38 samples corresponding to 22 HIV-1-infected patients, representing non-B subtypes A-F,
Genotypic resistance to zidovudine as a predictor of failure of subsequent therapy with human immunodeficiency virus type-1 nucleoside reverse-transcriptase inhibitors.: Eur J Clin Microbiol Infect Dis. 1999 Apr;18(4):274-82. Unique Identifier : AIDSLINE MED/99311742; Venturi G; Romano L; Catucci M; Riccio ML; De Milito A; Gonnelli A; Rubino M; Valensin PE; Zazzi M; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; To define factors predictive of failure to respond to nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type-1 (HIV-1)-infected subjects pretreated with zidovudine (ZDV), three groups of subjects shifted to double therapy with ZDV plus didanosine (ddI, n = 13), zalcitabine (
Etiology, clinical features and outcome of splenic microabscesses in HIV-infected patients with prolonged fever.: Eur J Clin Microbiol Infect Dis. 1999 May;18(5):324-9. Unique Identifier : AIDSLINE MED/99347387; Bernabeu-Wittel M; Villanueva JL; Pachon J; Alarcon A; Lopez-Cortes LF; Viciana P; Cadaval F; Talegon A; Department of Infectious Diseases, Hospital Universitario Virgen; del Rocio, Seville, Spain.; A prospective study was conducted to determine the etiology, clinical features, and outcome in a series of 32 consecutively enrolled HIV-infected patients with prolonged fever in whom high resolution (7.5 Mhz) sonography revealed multiple splenic microabscesses. Conventional (3.5 Mhz) sonography showed no splenic abno
Invasive group B streptococcal disease in nonpregnant adults.: Eur J Clin Microbiol Infect Dis. 1999 May;18(5):362-4. Unique Identifier : AIDSLINE MED/99347394; Perovic O; Crewe-Brown HH; Khoosal M; Karstaedt AS; Department of Clinical Microbiology and Infectious Diseases,; Chris Hani Baragwanath Hospital and University of the; Witwatersrand, Johannesburg, South Africa.; Forty episodes of invasive group B streptococcal infections in nonpregnant adults at Chris Hani Baragwanath Hospital, Soweto, South Africa , were retrospectively reviewed. The mean age of the patients was 45.6 years. Twenty (50%) patients were bacteraemic. Common predisposing condi
Multiple drug resistance genotype causing failure of antiretroviral treatment in an HIV-infected patient heavily exposed to nucleoside analogues.: Eur J Clin Microbiol Infect Dis. 1999 May;18(5):372-5. Unique Identifier : AIDSLINE MED/99347397; Villalba N; Gomez-Cano M; Holguin A; Soriano V; Department of Infectious Diseases, Hospital Carlos III, Instituto; de Salud Carlos III, Madrid, Spain.; A 37-year-old homosexual man began antiretroviral combination therapy with didanosine (ddI), lamivudine ( 3TC ) and indinavir (IDV) aft
Acute renal failure caused by indinavir in a patient with a single functioning kidney.: Eur J Clin Microbiol Infect Dis. 1999 May;18(5):386-7. Unique Identifier : AIDSLINE MED/99347401; Rodriguez-Hernandez MJ; Viciana P; Cordero E; de Alarcon A; Herrero M; Department of Infectious Diseases, University Hospital Virgen del; Rocio, Seville, Spain.
CCR5 genotype and human immunodeficiency virus type 1 infection in perinatally exposed infants.: Eur J Clin Microbiol Infect Dis. 1999 May;18(5):389-91. Unique Identifier : AIDSLINE MED/99347403; Villalba N; Perez-Olmeda M; de Jose M; Hernandez M; Sirera R; Espanol T; Gonzalez-Molina A; Soriano V; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
Serum IgG antibodies to human herpesvirus-6 (HHV-6) do not predict the progression of HIV disease to AIDS. Italian Seroconversion Study group.: Eur J Epidemiol. 1999 Apr;15(4):317-22. Unique Identifier : AIDSLINE MED/99341321; Dorrucci M; Rezza G; Andreoni M; Pezzotti P; Nicastri E; Ventura L; Zignani M; Alliegro MB; Tarantini G; Salassa B; Colangeli V; Mazzarello G; Ursitti MA; Barbanera M; Pristera R; Castelli F; Ortona L; Centro Operativo AIDS - Istituto Superiore di Sanita, Rome,; Italy.; OBJECTIVES: To evaluate if different levels of human herpesvirus 6 (HHV-6) antibodies can predict HIV disease progression. DESIGN: Longitudinal study of individuals with a documented date of HIV seroconversion. SETTING: Clinical centers located throughout Italy . PATIENTS: Individual
Gamma irradiation of bovine sera.: Dev Biol Stand. 1999;99:95-109. Unique Identifier : AIDSLINE MED/99331767; Plavsic MZ; Daley JP; Danner DJ; Weppner DJ; Cell Culture Research and Development, Life Technologies Inc.,; Grand Island, NY 14072, USA.
Immune effector mechanism in parasitic infections.: Immunol Lett. 1999 Jan;65(1-2):101-4. Unique Identifier : AIDSLINE MED/99163517; Liew FY; Xu D; Chan WL; Department of Immunology, University of Glasgow, UK.; fy11h@clinmed.gla.ac.uk; In this article is a summary of our recent findings on the role of nitric oxide (NO) as an effector mechanism against the intracellular parasite, Leishmania major. NO is produced in large amounts in murine macrophages following activation by IFNgamma synthesized by Th1 cells. NO production is inhibited by IL-4, a prod
HIV-1 DNA vaccines.: Immunol Lett. 1999 Jan;65(1-2):127-31. Unique Identifier : AIDSLINE MED/99163521; Fomsgaard A; Department of Virology, Statens Serum Institut, Copenhagen,; Denmark. afo@ssi.dk; HIV-1 was among the original DNA vaccine targets and HIV DNA vaccines are now in human trials. Lack of strong correlates of protective immunity makes vaccine design difficult; however, DNA vaccines have the potential to be an ideal vaccine and therapeutic approach against HIV-1. DNA vaccines induce conformational-depe
T-cell turnover in vivo and the role of cytokines.: Immunol Lett. 1999 Jan;65(1-2):21-5. Unique Identifier : AIDSLINE MED/99163505; Sprent J; Zhang X; Sun S; Tough D; Department of Immunology, IMM4, The Scripps Research Institute,; La Jolla CA 92037, USA. jsprent@scripps.edu; In addition to responding to specific antigen, CD8+ T-cells with a memory (CD44hi) phenotype undergo bystander proliferation when exposed to certain cytokines, notably type I interferons (IFN I), in vivo; such proliferation does not require T-cell receptor ligation. Since IFN I is unable to induce proliferation of pur
Chemokine receptors and their role in leukocyte activation.: Immunol Lett. 1999 Jan;65(1-2):35-40. Unique Identifier : AIDSLINE MED/99163507; Wells TN; Proudfoot AE; Power CA; Serono Pharmaceutical Research Institute, Geneva, Switzerland.; tim.wells@serono.com; Chemokines were originally isolated based on their abilities to selectively attract and recruit leukocyte populations. Over the last few years there has been an explosion in the number of new chemokines identified, and as a result many receptors previously considered to be orphans have now been paired up with their li
Checkpoints for regulation of development and IFN-gamma production by Th1 cells in TCR-transgenic models.: Immunol Lett. 1999 Jan;65(1-2):41-4. Unique Identifier : AIDSLINE MED/99163508; O'Garra A; DNAX Research Institute, Palo Alto, California 94304, USA.
The role of the viral glycoprotein in HIV-1 persistence.: Immunol Lett. 1999 Jan;65(1-2):63-70. Unique Identifier : AIDSLINE MED/99163512; McKeating JA; Balfe P; University of Reading, School of Animal and Microbial Sciences,; Whiteknights, UK.; The study of the immunological defects which arise from HIV infection has led to a deeper understanding both of the normal immune system and of the mechanisms by which it is damaged in disease. The interactions between viral and host factors during the early stages of HIV infection leads to a post-seroconversion stead
T lymphocyte dynamics during Listeria monocytogenes infection.: Immunol Lett. 1999 Jan;65(1-2):93-8. Unique Identifier : AIDSLINE MED/99163516; Busch DH; Pamer EG; Section of Infectious Diseases, Yale University, New Haven CT; 06520, USA.; Infection of mice with Listeria monocytogenes results in a robust T lymphocyte response that clears the pathogen and provides long term immunity from reinfection. The number of splenic CD4+ and CD8+ T cells and natural killer cells increases during primary and recall infection with L. monocytogenes, however the propor
Protein A of Staphylococcus aureus evokes Th1 type response in mice.: Immunol Lett. 1999 Apr 15;67(3):157-65. Unique Identifier : AIDSLINE MED/99295796; Sinha P; Ghosh AK; Das T; Sa G; Ray PK; Immunotechnology Section, Bose Institute, Calcutta, India.; Protein A (PA) of Staphylococcus aureus is known to elicit several cytokines such as IFN gamma, TNF alpha and IL1. However, it has not been delineated yet as to which differentiation pathway lymphocytes follow after stimulation by PA. In this report, we attempted to collect such evidences. Cytokines, such as IFN gamma
Dual specificity of a human neutralizing monoclonal antibody, specific for the V3 loop of GP120 (HIV-1).: Immunol Lett. 1999 Apr 15;67(3):185-92. Unique Identifier : AIDSLINE MED/99295799; Laisney IL; Strosberg AD; Laboratoire d'Immuno-Pharmacologie Moleculaire, UPR 0415,; Institut Cochin de Genetique Moleculaire, Paris, France.; i.laisney@lrz.uni-muenchen.de; Neutralizing antibodies specific for the third variable (V3) domain of gp120, the HIV-1 surface envelope protein, appear early in infection. However, they are usually highly specific for the priming isolate. To identify potential mimotopes of the V3 domain, we have screened a hexapeptide phage library with a human neu
Linomide downregulates autoimmunity through induction of TH2 cytokine production by lymphocytes.: Immunol Lett. 1999 Apr 15;67(3):203-8. Unique Identifier : AIDSLINE MED/99295801; Karussis D; Abramsky O; Rosenthal Y; Mizrachi-Koll R; Ovadia H; Department of Neurology, Hadassah-Hebrew University Hospital,; Jerusalem, Israel. karus@cc.huji.ac.il; Linomide is a synthetic immunomodulator that has been shown to protect animals against a wide range of spontaneously developing or induced autoimmune diseases. We have previously reported that Linomide blocks both the clinical and the histopathological manifestations of experimental autoimmune encephalomyelitis (EAE)
Generation and function of bone marrow-derived dendritic cells from CD4/CD8(-/-) double-knockout mice.: Immunol Lett. 1999 Apr 15;67(3):243-9. Unique Identifier : AIDSLINE MED/99295807; Corsi MM; Sandberg JK; Wasserman K; Maes HH; Kiessling R; Institute of General Pathology, Faculty of Medicine, University; of Milan, Italy.; We present a novel, simple and straightforward method to obtain mouse bone marrow-derived dendritic cells (DC) from C57Bl/6 CD4/CD8(-/-) double knock-out mice. This new method, involving culture of bone marrow cells in medium supplemented with Interleukin 4 and Granulocyte-Macrophage Colony-Stimulating Factor, does no
CD8+ lymphocyte-mediated suppression of human immunodeficiency virus type 1 expression in human brain cells.: Immunol Lett. 1999 Apr 15;67(3):257-61. Unique Identifier : AIDSLINE MED/99295809; Lokensgard JR; Gekker G; Hu S; Chao CC; Simpson M; Schut RL; Peterson PK; Institute for Brain and Immune Disorders, Minneapolis Medical; Research Foundation, and University of Minnesota Medical School; 55404, USA. jlokensg@biosci.cbs.umn.edu
IL-10 up-regulates CCR5 gene expression in human monocytes.: Inflammation. 1999 Jun;23(3):241-51. Unique Identifier : AIDSLINE MED/99319929; Houle M; Thivierge M; Le Gouill C; Stankova J; Rola-Pleszczynski M; Department of Pediatrics Faculty of Medicine, Universite de; Sherbrooke, Quebec, Canada.; The chemokine receptor CCR5 has been found to play a key role in early infection with macrophage-tropic isolates of HIV-1 and CCR5 deficiency is associated with a relative resistance to HIV-1 infection. In this context, we studied the regulation of CCR5 gene expression by cytokines, and in particular, interleukin (IL)
Effects of cognitive-behavioral interventions on quality of life in persons with HIV.: Int J Nurs Stud. 1999 Jun;36(3):223-33. Unique Identifier : AIDSLINE MED/99332363; Eller LS; Rutgers, State University of New Jersey, Newark 07102-1897, USA.; eller@nightingale.rutgers.edu; This study explored the effects of cognitive-behavioral interventions on quality of life in persons with HIV. In a randomized, 3 x 3 block design, 69 participants were assigned to a guided imagery, progressive muscle relaxation or control group. Following brief instruction, subjects practiced their respective interven
Human immunodeficiency virus and hepatitis B virus infection in pregnancy: diagnostic potential of viral genome detection.: Intervirology. 1998;41(4-5):201-7. Unique Identifier : AIDSLINE MED/99234158; Berger A; Doerr HW; Weber B; Institut fur Medizinische Virologie, Zentrum der Hygiene,; Universitatskliniken, Frankfurt am Main, Germany.; Berger@em.uni-frankfurt.de; Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) account for millions of cases of vertical infections worldwide. Laboratory diagnosis is essential for the detection of potentially infectious carriers. HBeAg represents the best serological marker for HBV replication. Since 10% of HBeAg-negative carriers t
A prospective study on mother-to-infant transmission of hepatitis C virus.: Intervirology. 1998;41(4-5):208-12. Unique Identifier : AIDSLINE MED/99234159; Zanetti AR; Tanzi E; Romano L; Zuin G; Minola E; Vecchi L; Principi N; Institute of Virology, University of Milan, Milan, Italy.; To assess the rate of mother-to-infant transmission of hepatitis C virus (HCV) and to identify potential risk factors for transmission, we followed up (mean 22.4 months, range 1-7.5 years) a cohort of 291 babies born to anti-HCV-positive mothers, 40 of whom were also HIV coinfected. Seventeen (5.8%) babies acquired HC
Antiviral efficacy of disinfectant solution MRI-1.: Intervirology. 1998;41(6):238-43. Unique Identifier : AIDSLINE MED/99262529; Skinner GR; Billstrom M; Randall S; Buchan A; Davies J; Ahmad A; Vaccine Research Trust, Harborough Banks, Lapworth, UK.; Disinfectant MRI-1 was prepared by dissolution of non-ionic and ionic detergent in ethanol. The disinfectant inactivated extracellular and intracellular enveloped and non-enveloped viruses including herpes viruses, influenza A and human immunodeficiency disease virus in suspension or on surfaces by pre-exposure or pos
HIV pioneer stands up for patients' rights.: J Ark Med Soc. 1999 Jul;96(2):52-3. Unique Identifier : AIDSLINE MED/99368434; Gardner N
Guidelines for the diagnosis and management of asthma: accepting the challenge.: J Asthma. 1999 Aug;36(5):391-407. Unique Identifier : AIDSLINE MED/99389025; Creer TL; Winder JA; Tinkelman D; Intermountain Allergy & Asthma Clinic, Salt Lake City, Utah, USA.
Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells.: J Biol Chem. 1999 Aug 6;274(32):22373-9. Unique Identifier : AIDSLINE MED/99357764; Hsiao PW; Chang C; Departments of Pathology, Urology, and Radiation Oncology, George; Whipple Laboratory for Cancer Research, University of Rochester,; Rochester, New York 14642, USA.; The androgen receptor (AR) is a member of the steroid receptor superfamily that may require coactivators for proper or maximal transactivation. Using a purified AR N-terminal peptide as a probe to screen the human testis expression library, we identified an androgen-enhanced AR N-terminal-associated protein ARA160, wh
IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein.: J Biol Chem. 1999 Aug 13;274(33):22911-4. Unique Identifier : AIDSLINE MED/99367408; Harhaj EW; Sun SC; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.; The tax gene product of human T-cell leukemia virus type I induces activation of transcription factor NF-kappaB, which contributes to deregulated expression of various cellular genes. Tax expression triggers persistent phosphorylation and degradation of the NF-kappaB inhibitory proteins IkappaBalpha and IkappaBbeta, r
Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism.: Unique Identifier : AIDSLINE GENBANK; Louis JM; Wondrak EM; Kimmel AR; Wingfield PT; Nashed NT; Previously it was demonstrated using a model precursor that processing at the N terminus of the HIV-1 protease (PR) precedes processing at its C terminus. We now show the expression, purification, and kinetics of the autoprocessing reaction of a PR precursor linked to 53 amino acids of the native flanking transframe r
Roles of CD4 and coreceptors in binding, endocytosis, and proteolysis of gp120 envelope glycoproteins derived from human immunodeficiency virus type 1.: Unique Identifier : AIDSLINE MED/99367483; Kozak SL; Kuhmann SE; Platt EJ; Kabat D; Infections by human immunodeficiency virus type 1 (HIV-1) involve interactions of the viral envelope glycoprotein gp120 with CD4 and then with a coreceptor. R5 isolates of HIV-1 use CCR5 as a coreceptor, whereas X4 isolates use CXCR4. It is not known whether coreceptors merely trigger fusion of the viral and
Development of a fluorogenic polymerase chain reaction assay (TaqMan) for the detection and quantitation of varicella zoster virus.: J Virol Methods. 1999 Apr;79(1):33-40. Unique Identifier : AIDSLINE MED/99259085; Hawrami K; Breuer J; Department of Medical Microbiology, St Bartholomew's and the; London School of Medicine and Dentistry, UK.; k.hawrami@mds.qmw.ac.uk; A TaqMan based polymerase chain reaction (PCR) assay was developed for the detection and quantitation of varicella zoster virus (VZV). This method enables simple, reproducible, sensitive and specific detection and quantification of VZV. The TaqMan assay was able to detect four copies of VZV and did not cross-react wit
Enhanced replication of M-tropic HIV-1 strains in Herpesvirus saimiri immortalised T-cells which express CCR5.: J Virol Methods. 1999 Apr;79(1):51-63. Unique Identifier : AIDSLINE MED/99259087; Vella C; Zheng NN; Vella G; Atkins C; Bristow RG; Fickenscher H; Daniels RS; The National Institute for Medical Research, Mill Hill, London,; UK. c.vella@qmw.ac.uk; A better characterisation of mononuclear cell-tropic (M-tropic) HIV-1 is central to disease control as these viruses predominate in disease transmission. M-tropic viruses do not replicate in conventional T-cell lines, and virus titres obtained in peripheral blood mononuclear cells (PBMC) are low. Human T-lymphocytes w
Generation of monoclonal antibodies to native human immunodeficiency virus type 1 envelope glycoprotein by immunization of mice with naked RNA.: Unique Identifier : AIDSLINE MED/99259089; Giraud A; Ataman-Onal Y; Battail N; Piga N; Brand D; Mandrand B; Verrier B; The Semliki Forest virus (SFV) vector system is a new approach for in vivo expression of heterologous proteins and can also be used to generate specific immune responses in animal models. HIV-1 envelope glycoprotein produced using the SFV expression system is correctly folded, cleaved, transported to the cell surface
Techniques for the evaluation of nucleic acid amplification technology performance with specimens containing interfering substances: efficacy of boom methodology for extraction of HIV-1 RNA.: J Virol Methods. 1999 Apr;79(1):97-111. Unique Identifier : AIDSLINE MED/99259091; Witt DJ; Kemper M; Organon Teknika Corporation, Durham, NC 27712, USA.; dwitt@orgtek.com; Accurate HIV-1 RNA quantitation with nucleic acid amplification assays (NAAA) is partly dependent on overall assay design to ensure proper and reproducible functioning in the presence of endogenous interfering substances present in a clinical specimen, or exogenous interfering substances introduced as a result of spec
Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study.: J Clin Microbiol. 1999 Sep;37(9):2848-51. Unique Identifier : AIDSLINE MED/99380294; Winkler IG; Lochelt M; Flower RL; School of Pharmacy and Medical Science, University of South; Australia, City East, North Terrace, Adelaide, South Australia,; 5000, Australia. Ingrid.Winkler@imvs.sa.gov.au; Although foamy viruses (Spumaviruses) have repeatedly been isolated from both healthy and diseased cats, cattle, and primates, the primary mode of transmission of those common viruses remains undefined. A database of the feline foamy virus (FeFV) and feline immunodeficiency virus (FIV) antibody status, age, and sex of
Polymorphism of the human immunodeficiency virus type 1 (HIV-1) protease gene and response of HIV-1-infected patients to a protease inhibitor.: J Clin Microbiol. 1999 Sep;37(9):2910-2. Unique Identifier : AIDSLINE MED/99380305; Bossi P; Mouroux M; Yvon A; Bricaire F; Agut H; Huraux JM; Katlama C; Calvez V; Department of Virology, Pitie-Salpetriere Hospital, Paris,; France.; In order to analyze the impact of protease gene polymorphism on response to regimens containing a protease inhibitor, the entire protease coding domain from 58 human immunodeficiency virus type 1 (HIV-1)-infected patients who were protease inhibitor naive was sequenced before therapy was started. Plasma HIV-1 RNA leve
Human immunodeficiency virus type 1 cloning vectors for antiretroviral resistance testing.: Unique Identifier : AIDSLINE MED/99380311; Martinez-Picado J; Sutton L; De Pasquale MP; Savara AV; D'Aquila RT; Massachusetts General Hospital, Boston, Massachusetts 02129, USA.; Better detection of minority human immunodeficiency virus type 1 (HIV-1) populations containing gene mutations may improve the usefulness of antiretroviral resistance testing for clinical management. Molecular cloning of HIV-1 PCR products which might improve minority detection can be slow and difficult, and commercia
Hepatitis B virus (HBV) mutations associated with resistance to lamivudine in patients coinfected with HBV and human immunodeficiency virus.: J Clin Microbiol. 1999 Sep;37(9):3013-6. Unique Identifier : AIDSLINE MED/99380324; Thibault V; Benhamou Y; Seguret C; Bochet M; Katlama C; Bricaire F; Opolon P; Poynard T; Agut H; Laboratoire de Virologie, Service d'Hepato-Gastro-Enterologie,; Service des Maladies Infectieuses, Groupe Hospitalier; Pitie-Salpetriere, 75013 Paris, France.; vincent.thibault@psl.ap-hop-paris.fr; Mutations associated with hepatitis B virus (HBV) resistance to lamivudine have not been extensively addressed in human immunodeficiency virus (HIV)-HBV coinfection. We have studied the HBV polymerase sequences from nine coinfected patients who experienced HBV recurrence while under lamivudine treatment. In seven of t
Neuron loss and axon reorganization in the dentate gyrus of cats infected with the feline immunodeficiency virus.: Unique Identifier : AIDSLINE MED/99352383; Mitchell TW; Buckmaster PS; Hoover EA; Whalen LR; Dudek FE; The pathophysiological bases of cognitive, motor, and behavioral abnormalities in patients infected with the human immunodeficiency virus (HIV-1) remain largely unknown. To test the possibility that changes in hippocampal neuronal structure may contribute to these neurologic abnormalities, we examined the brains of ca
Sarcoidosis in a patient with AIDS: a manifestation of immune restoration syndrome.: J Am Acad Dermatol. 1999 Aug;41(2 Pt 2):285-6. Unique Identifier : AIDSLINE MED/99355863; Mirmirani P; Maurer TA; Herndier B; McGrath M; Weinstein MD; Berger TG; University of California, Department of Dermatology, San; Francisco, CA 94143-0316, USA. paradi@itsa.ucsf.edu; Sarcoidosis has been rarely reported in the presence of HIV infection. Helper T-lymphocyte depletion may attenuate granuloma formation. We present a patient who developed active sarcoidosis after being started on highly active antiretroviral therapy (HAART), which increased his CD4 count and decreased his viral load.
Antiretroviral therapy for HIV infection: a review of current medications and therapies.: J Am Optom Assoc. 1999 Jun;70(6):355-83. Unique Identifier : AIDSLINE MED/99366392; Bright DC; Optometry Department, West Los Angeles Healthcare Center/VAGLAHS,; California, USA.; BACKGROUND: Management of HIV infection has been revolutionized in the past 3 years by the introduction of drugs significantly more potent than those previously available. Simultaneously revelations about dynamics of HIV infection and viral replication have altered concepts about HIV disease, as well as the need for t
Sarcoidosis-related anterior uveitis in a patient with human immunodeficiency virus.: J Am Optom Assoc. 1999 Jun;70(6):384-90. Unique Identifier : AIDSLINE MED/99366393; Lee AK; Chronister CL; Eye Institute, Pennsylvania College of Optometry, Philadelphia,; Pennsylvania, USA.; BACKGROUND: This is the first ophthalmic report--to our knowledge--of an anterior uveitis secondary to sarcoidosis in a patient infected with human immunodeficiency virus (HIV). Other reported causes of uveitis in HIV-infected patients have included HIV, herpes zoster, tuberculosis, syphilis, toxoplasmosis, cryptococc
Central serous chorioretinopathy and HIV.: Unique Identifier : AIDSLINE MED/99366394; Spalding JM; VA Medical Center, Baltimore, Maryland, USA.; BACKGROUND: Patients with central serous chorioretinopathy (CSC) have sudden-onset, painless, uniocular blur that is typically diagnosed via fundus and fluorescein angiographic appearance. The etiology and pathophysiology are not fully understood; however, there may be an association with an infectious etiology. This
HIV-1 viral load testing.: J Infect. 1999 May;38(3):141-6. Unique Identifier : AIDSLINE MED/99352077; Clarke JR; McClure MO; Department of Genitourinary Medicine and Communicable Diseases,; Imperial College School of Medicine, St Mary's Hospital,; Paddington, London, UK.
Measurement of plasma HIV viral load--clinical applications.: J Infect. 1999 May;38(3):147-50. Unique Identifier : AIDSLINE MED/99352078; Churchill D; Weber J; Division of Medicine, Imperial College School of Medicine, St.; Mary's Hospital, London, UK.
HIV and tuberculosis co-infection in an inner London hospital--a prospective anonymized seroprevalence study.: J Infect. 1999 May;38(3):162-6. Unique Identifier : AIDSLINE MED/99352081; Marshall BG; Mitchell DM; Shaw RJ; Marais F; Watkins RM; Coker RJ; Department of Respiratory Medicine, St. Mary's NHS Trust, London,; UK.; OBJECTIVES: Since 1987 there has been an increase in tuberculosis notifications in the U.K., with this increase disproportionately affecting London. A recent national survey suggests that co-infection with HIV occurs in less than 5% of tuberculosis patients. This study asked if local co-infection rates in Inner London
Pseudomonas aeruginosa infection in human immunodeficiency virus infected patients.: J Infect. 1999 May;38(3):176-81. Unique Identifier : AIDSLINE MED/99352084; Meynard JL; Barbut F; Guiguet M; Batisse D; Lalande V; Lesage D; Guiard-Schmid JB; Petit JC; Frottier J; Meyohas MC; Service des Maladies Infectieuses et Tropicales, Hopital; Saint-Antoine, Paris, France.; OBJECTIVES: (1) To determine the incidence and outcome of Pseudomonas aeruginosa infection in HIV-infected patients. (2) To study the antimicrobial susceptibility of P. aeruginosa isolates in this particular population. (3) To identify risk factors for these infections. PATIENTS AND METHODS: A retrospective case-contr
[Successful treatment of primary CNS lymphoma diagnosed by 201thallium-single photon emission computed tomography (201Tl-SPECT) with whole-brain radiation therapy in an AIDS patient]: Kansenshogaku Zasshi. 1999 Jun;73(6):609-13. Unique Identifier : AIDSLINE MED/99352753; Okubo T; Ihata A; Nakamura M; Ueda A; Ohno S; Hagiwara E; Shirai A; Kanamori H; Ishigatsubo Y; First Department of Internal Medicine, Yokohama City University; School of Medicine, Japan.; The patient, a 51-year-old male with a two year history of AIDS, was admitted to our hospital because of hemiparalysis and vomiting. The MRI study showed multiple lesions with ring-enhancement in the right basal brain area. Empirical therapy for toxoplasma encephalitis was started. After 64 days, the subsequent brain
Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure.: J Med Virol. 1999 Aug;58(4):373-7. Unique Identifier : AIDSLINE MED/99347772; Bourlet T; Guglielminotti C; Evrard M; Berthelot P; Grattard F; Fresard A; Lucht FR; Pozzetto B; Groupe Immunite des Muqueuses et Agents Pathogenes, University; of Saint-Etienne, Faculty of Medicine, Department of; Microbiology, France.; GB virus C (GBV-C) or hepatitis G virus (HGV) is transmitted by the parenteral route but the importance of sexual transmission needs to be ascertained. GBV-C/HGV infections were investigated using RNA and E2-antibody detection methods in 80 subjects infected by the human immunodeficiency virus type 1 (HIV-1) divided i
Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus.: J Med Virol. 1999 Aug;58(4):387-93. Unique Identifier : AIDSLINE MED/99347774; Saijo M; Suzutani T; Itoh K; Hirano Y; Murono K; Nagamine M; Mizuta K; Niikura M; Morikawa S; Department of Pediatrics, Asahikawa Medical College, Hokkaido,; Japan. msaijo@nih.go.jp; Recurrent acyclovir (ACV)-resistant (ACV-r) herpes simplex virus type 1 (HSV-1) infections occurred in a patient with Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency syndrome composed of three clinical characteristics of immunodeficiency, thrombocytopenia, and a
Establishing and characterizing a CD30-positive cell line harboring HHV-8 from a primary effusion lymphoma.: J Med Virol. 1999 Aug;58(4):394-401. Unique Identifier : AIDSLINE MED/99347775; Katano H; Hoshino Y; Morishita Y; Nakamura T; Satoh H; Iwamoto A; Herndier B; Mori S; Department of Pathology, Institute of Medical Science, University; of Tokyo, Japan.; Primary effusion lymphoma (PEL, or body-cavity-based lymphoma [BCBL]) is a new subtype of non-Hodgkin s lymphoma in which tumor cells locate in the body cavity exclusively. PEL/BCBL is widely accepted as one of the neoplastic complications of AIDS, associated mostly with human herp
Quantitative changes in cytomegalovirus DNAemia and genetic analysis of the UL97 and UL54 genes in AIDS patients receiving cidofovir following ganciclovir therapy.: J Med Virol. 1999 Aug;58(4):402-7. Unique Identifier : AIDSLINE MED/99347776; Bowen EF; Cherrington JM; Lamy PD; Griffiths PD; Johnson MA; Emery VC; Department of Virology, Royal Free and University College Medical; School of University College London, England.; Five AIDS patients with cytomegalovirus ( CMV ) retinitis who had received ganciclovir (GCV) therapy were followed with serial blood sampling to detectchanges both in CMV load and in the genetic composition of genes UL97 and UL
Identification of a new control region in the genome of the DDP strain of BK virus isolated from PBMC.: J Med Virol. 1999 Aug;58(4):413-9. Unique Identifier : AIDSLINE GENBANK/U91605; Degener AM; Pietropaolo V; Di Taranto C; Jin L; Ameglio F; Cordiali-Fei P; Trento E; Sinibaldi L; Orsi N; Department of Cellular and Developmental Biology, University "La; Sapienza", Rome, Italy.; The various strains of human polyomavirus BK (BKV) show a marked heterogeneity in the non-coding control region (NCCR), which includes the origin of replication and the regulatory region for early and late transcription. A new BKV strain (DDP, U91605) was identified by direct detection and sequencing of PCR products o
A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale.: J Nat Prod. 1999 Jun;62(6):927-30. Unique Identifier : AIDSLINE MED/99324064; Wessels M; Konig GM; Wright AD; Institute for Pharmaceutical Biology, Technical University of; Braunschweig, Mendelssohnstrasse 1, D-38106 Braunschweig,; Germany.; From the lipophilic extract of the marine brown alga Stypopodium zonale (Dictyotaceae) the new terpenoid compound stypoquinonic acid (1) together with the known compounds taondiol (2) and atomaric acid (3) were isolated. The structures of all isolates were