[Study of histoenzymatic activity of isocitrate-DH in the hepatic tissue of rats treated with AZT: image analysis] NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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[Study of histoenzymatic activity of isocitrate-DH in the hepatic tissue of rats treated with AZT: image analysis]

An Med Interna. 1998 Dec;15(12):638-41. Unique Identifier : AIDSLINE MED/99138544
Corcuera Pindado MT; Carbajo Perez S; Gomez Aguado F; Roldan Contreras M; Picazo Talavera A; Alonso Martin MJ; Servicio de Anatomia Patologica, Instituto de Salud Carlos III,; Madrid.

Abstract: OBJECTIVE: Recently has been described alterations in different organs of HIV + patients treated with zidovudine (AZT), as secondary effect from drug administration. METHOD: We have developed and experimental rat model, in which the rats were administered AZT in drinking water and we have analysed the activity of enzyme isocitrate DH, of Krebs cycle, in hepatic tissue sections. Histological technique were employed and image analysis to objectivate the results. RESULTS: A significant statistic decrease of the enzyme activity in those animals treated with AZT were observed, compared with the control groups. CONCLUSIONS: The modification from enzyme activities related with Krebs cycle can be traduced in mitochondrial alterations, that could have direct or indirect influence in the appearance of some associated pathologies to the AZT treatment.
Keywords: JOURNAL ARTICLE hepatico de ratas tratadas con AZT mediante analisis de imagen. Animal Anti-HIV Agents/*PHARMACOLOGY Comparative Study English Abstract Histocytochemistry *Image Processing, Computer-Assisted Isocitrate Dehydrogenase/*ANALYSIS Liver/*DRUG EFFECTS/*ENZYMOLOGY Rats Rats, Sprague-Dawley Zidovudine/*PHARMACOLOGYKWDjournalarticlehepaticoderatastratadasconaztmedianteanalisisdeimagenKWDanimalanti-hivagents/KWDpharmacologycomparativestudyenglishabstracthistocytochemistryKWDimageprocessing,computer-assistedisocitratedehydrogenase/KWDanalysisliver/KWDdrugeffects/KWDenzymologyratsrats,sprague-dawleyzidovudine/KWDpharmacology
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A9950966

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