Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients.

Eur J Oral Sci. 1998 Dec;106(6):979-85. Unique Identifier : AIDSLINE MED/99094517
Grimoud AM; Arnaud C; Dellamonica P; Lodter JP; Laboratory for Oro-Facial Biology, Faculty of Dentistry, Toulouse; III University and Hotel Dieu, University Hospital, France.; doydenta@adm.ups-tlse.fr

Abstract: The objective of this study was to determine the relationships between saliva protein concentrations, oral mucosal lesions, and systemic parameters in HIV positive patients and controls. Twenty-three control volunteers and 58 HIV-antibody positive patients received a complete oral examination and medical evaluation. In saliva and serum samples, protein concentrations were recorded by a nephelometric method. The systemic parameters assessed were CD4+ cell count, CDC stages and antiretroviral therapy. Oral mucosal lesion prevalence was higher among subjects with lower CD4+ counts. Considering the protein profile, correlations were recorded between saliva and serum protein concentration for IgA, haptoglobin and alpha1-proteinase inhibitor. Using assays of immune and non-immune saliva defence factors, we found that the evolution of cellular immuno-suppression during HIV infection was correlated to oral mucosal disease, showing a relationship between local and general systems.

Keywords: JOURNAL ARTICLE alpha 1-Antitrypsin/ANALYSIS alpha-Macroglobulins/ANALYSIS Adult Albumins/ANALYSIS Blood Proteins/ANALYSIS Candidiasis, Oral/BLOOD/COMPLICATIONS/IMMUNOLOGY Case-Control Studies Complement 3/ANALYSIS CD4 Lymphocyte Count Female Haptoglobins/ANALYSIS Human HIV Seropositivity/BLOOD/COMPLICATIONS/*IMMUNOLOGY Immunity, Cellular Immunity, Mucosal Immunoglobulin Isotypes/ANALYSIS/BLOOD Leukoplakia, Hairy/BLOOD/COMPLICATIONS/IMMUNOLOGY Male Middle Age Mouth Mucosa/PATHOLOGY Nephelometry and Turbidimetry Orosomucoid/ANALYSIS Periodontitis/BLOOD/COMPLICATIONS/IMMUNOLOGY Salivary Proteins/*ANALYSIS/*IMMUNOLOGY Statistics, Nonparametric Transferrin/ANALYSIS
990530
A9950940

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