Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

Immunity. 1999 Jan;10(1):39-49. Unique Identifier : AIDSLINE MED/99146374
Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I; Akira S; Department of Biochemistry, Hyogo College of Medicine,; Nishinomiya, Japan.

Abstract: We have generated mice with a cell type-specific disruption of the Stat3 gene in macrophages and neutrophils. The mutant mice are highly susceptible to endotoxin shock with increased production of inflammatory cytokines such as TNF alpha, IL-1, IFN gamma, and IL-6. Endotoxin-induced production of inflammatory cytokines is augmented because the suppressive effects of IL-10 on inflammatory cytokine production from macrophages and neutrophils are completely abolished. The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10.
Keywords: JOURNAL ARTICLE Animal Cell Differentiation/IMMUNOLOGY Chronic Disease Crosses, Genetic DNA-Binding Proteins/*GENETICS Enterocolitis/*GENETICS/*IMMUNOLOGY/PATHOLOGY Genetic Predisposition to Disease Interleukin-10/PHYSIOLOGY Lipopolysaccharides/TOXICITY Macrophage Activation/GENETICS Macrophages, Peritoneal/*METABOLISM Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Neutrophils/*METABOLISM Shock, Septic/GENETICS/IMMUNOLOGY Support, Non-U.S. Gov't Th1 Cells/*IMMUNOLOGY/PATHOLOGY Trans-Activators/*GENETICSKWDjournalarticleanimalcelldifferentiation/immunologychronicdiseasecrosses,geneticdna-bindingproteins/KWDgeneticsenterocolitis/KWDgenetics/KWDimmunology/pathologygeneticpredispositiontodiseaseinterleukin-10/physiologylipopolysaccharides/toxicitymacrophageactivation/geneticsmacrophages,peritoneal/KWDmetabolismmicemice,inbredc57blmice,inbredstrainsmice,knockoutneutrophils/KWDmetabolismshock,septic/genetics/immunologysupport,non-uKWDsKWDgov'tth1cells/KWDimmunology/pathologytrans-activators/KWDgenetics
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