RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.

Unique Identifier : AIDSLINE MED/99146379
Song A; Chen YF; Thamatrakoln K; Storm TA; Krensky AM; Department of Pediatrics, Stanford University School of Medicine,; California 94305-5208, USA.

Abstract: RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.

Keywords: JOURNAL ARTICLE Adult Amino Acid Sequence Animal Base Sequence Binding Sites/GENETICS Cell Line COS Cells DNA-Binding Proteins/BIOSYNTHESIS/*ISOLATION & PURIF/METABOLISM/ *PHYSIOLOGY *Gene Expression Regulation Human Lymphocyte Transformation Molecular Sequence Data Organ Specificity/GENETICS Promoter Regions (Genetics) Proto-Oncogene Proteins/METABOLISM RANTES/BIOSYNTHESIS/*GENETICS Support, Non-U.S. Gov't
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A9950929

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