[Effect of HIV envelope glycoprotein on the induction of immune dysregulation in HIV infection] NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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[Effect of HIV envelope glycoprotein on the induction of immune dysregulation in HIV infection]

Nihon Rinsho Meneki Gakkai Kaishi. 1998 Feb;21(1):11-9. Unique Identifier : AIDSLINE MED/99100284
Sekigawa I; Akimoto H; Kaneko H; Department of Medicine, Juntendo Izu-Nagaoka Hospital, Juntendo; University School of Medicine.

Abstract: The envelope glycoprotein of human immunodeficiency virus (HIV) has been know to play an important role in the induction of immune dysregulation of HIV infection. Recent evidence suggests that HIV requires the chemokine receptors as a coreceptor. In addition, we found that HIV-2 (but not HIV-1) envelope glycoprotein can bind to not only CD 4 but also CD 8 molecules on human T cells. Based upon these findings, we discuss the effect of HIV envelope glycoprotein on the pathogenic role of HIV infection and the difference between HIV-1 and HIV-2 envelope glycoproteins in the biological characteristics and pathogenecity.
Keywords: JOURNAL ARTICLE REVIEW REVIEW LITERATURE Chemokines/BIOSYNTHESIS Comparative Study English Abstract Gene Products, env/*IMMUNOLOGY Human HIV Envelope Protein gp120/*IMMUNOLOGY HIV Infections/*IMMUNOLOGY *Immune ToleranceKWDjournalarticlereviewreviewliteraturechemokines/biosynthesiscomparativestudyenglishabstractgeneproducts,env/KWDimmunologyhumanhivenvelopeproteingp120/KWDimmunologyhivinfections/KWDimmunologyKWDimmunetolerance
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