Bacterial extract OM85-BV induces interleukin-12-dependent IFN-gamma production by human CD4+ T cells. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Bacterial extract OM85-BV induces interleukin-12-dependent IFN-gamma production by human CD4+ T cells.

J Interferon Cytokine Res. 1998 Oct;18(10):817-21. Unique Identifier : AIDSLINE MED/99025488
Byl B; Libin M; Gerard M; Clumeck N; Goldman M; Mascart-Lemone F; Department of Immunology, Hopital Erasme, Brussels, Belgium.

Abstract: To obtain insight into the possible mode of action of bacterial extracts used as immunostimulants in Europe, we used the ELISPOT technique to investigate the effects of one of them (OM85-BV, Broncho-Vaxom) on interferon-y (IFN-gamma) production by peripheral blood mononuclear cells (PBMC). We found that (1) OM85-BV stimulates IFN-gamma secretion by PBMC from normal individuals and human immunodeficiency virus (HIV)-infected patients, (2) CD4+ cells represent the major source of IFN-gamma produced in response to OM85-BV, and (3) this effect of OM85-BV involves the induction of interleukin-12 (IL-12) secretion by accessory cells. We conclude that bacterial extracts might enhance antimicrobial defenses by eliciting IL-12-dependent IFN-gamma synthesis by CD4+ T cells.
Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/PHYSIOPATHOLOGY Adjuvants, Immunologic/*PHARMACOLOGY Case-Control Studies CD4-Positive T-Lymphocytes/*DRUG EFFECTS/METABOLISM Human Immunophenotyping Interferon Inducers/*PHARMACOLOGY Interferon Type II/*BIOSYNTHESIS Interleukin-12/*PHYSIOLOGY/SECRETION Leukocytes, Mononuclear/DRUG EFFECTS/SECRETION Reference Values Support, Non-U.S. Gov'tKWDjournalarticleacquiredimmunodeficiencysyndrome/physiopathologyadjuvants,immunologic/KWDpharmacologycase-controlstudiescd4-positivet-lymphocytes/KWDdrugeffects/metabolismhumanimmunophenotypinginterferoninducers/KWDpharmacologyinterferontypeii/KWDbiosynthesisinterleukin-12/KWDphysiology/secretionleukocytes,mononuclear/drugeffects/secretionreferencevaluessupport,non-uKWDsKWDgov't
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