[Lack of air conditioning and mycotoxin poisoning are basic co-factors in tropical spastic paraparesis] NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


[Lack of air conditioning and mycotoxin poisoning are basic co-factors in tropical spastic paraparesis]

Rev Neurol. 1998 Apr;26(152):564-7. Unique Identifier : AIDSLINE MED/99012098
Leon FE; Carpintero M; Bayona J; Gaffga N; Ocampo L; del Castillo N; Department of Neurology, University of Alabama at Birmingham,; USA.

Abstract: INTRODUCTION: Chronic idiopathic spastic paraparesis (CHISPA) have been associated to HTLV-I virus infection, and unknown environmental factors have been suggested to play a role in its pathogenesis. METHOD: Based in our previous studies we wanted to know if the lack of refrigerators and the mycotoxin contamination of food might have any relationship with the presence of CHISPA in patients living at southeastern Colombia. RESULTS: Interestingly only four out of 15 patients with CHISPA had some method of refrigeration, in, 14 out of these 15 patients at least a metabolite of Fusarium was detected. CONCLUSIONS: The fact that mycotoxins found in the urine samples of these patients are immunosuppressors and demyelinating allow us to suggest that these toxins could be the most important environmental cofactors leading to the susceptible people to the clinically established disease.
Keywords: JOURNAL ARTICLE cofactores fundamentales en la paraparesia espastica tropical. Adult Aged *Air Conditioning Chronic Disease Colombia English Abstract Female Food Poisoning/COMPLICATIONS Human HTLV-BLV Infections/VIROLOGY HTLV-I/ISOLATION & PURIF Male Middle Age Mycotoxins/*ADVERSE EFFECTS/URINE Paraparesis, Tropical Spastic/*ETIOLOGY/VIROLOGYKWDjournalarticlecofactoresfundamentalesenlaparaparesiaespasticatropicalKWDadultagedKWDairconditioningchronicdiseasecolombiaenglishabstractfemalefoodpoisoning/complicationshumanhtlv-blvinfections/virologyhtlv-i/isolation&purifmalemiddleagemycotoxins/KWDadverseeffects/urineparaparesis,tropicalspastic/KWDetiology/virology
990530
A9950921

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .