Protease inhibitors, diabetes mellitus and blood lipids. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Protease inhibitors, diabetes mellitus and blood lipids.

Diabetes Metab. 1998 Dec;24(6):547-9. Unique Identifier : AIDSLINE MED/99131015
Meyer L; Rabaud C; Ziegler O; May T; Drouin P; Service de Diabetologie, CHU Nancy, France.

Abstract: We report the case of a patient with human immunodeficiency virus (HIV) and no familial or personal history of metabolic disease, who experienced two diabetes decompensations (severe hyperglycaemia without ketonuria) associated with severe hypertriglyceridaemia, after the introduction of protease inhibitors. Initial insulin therapy at high doses (2 IU/kg/day) was required, and metabolic control was restored within several weeks without treatment after withdrawal of protease inhibitors. This case confirms that due attention must be paid to both blood glucose and plasma triglyceride levels in HIV-infected patients treated with protease inhibitors.
Keywords: JOURNAL ARTICLE Adult Case Report Diabetes Mellitus/BLOOD/*IMMUNOLOGY Human HIV Protease Inhibitors/*THERAPEUTIC USE HIV Seropositivity/*DRUG THERAPY Lipids/*BLOOD MaleKWDjournalarticleadultcasereportdiabetesmellitus/blood/KWDimmunologyhumanhivproteaseinhibitors/KWDtherapeuticusehivseropositivity/KWDdrugtherapylipids/KWDbloodmale
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