Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.
Evaluation of syndromic patient management algorithm for urethral discharge.
Sex Transm Infect. 1998 Jun;74 Suppl 1:S29-33. Unique Identifier : AIDSLINE MED/99147431 Djajakusumah T; Sudigdoadi S; Keersmaekers K; Meheus A; Department of Dermatovenereology, Universitas Padjadjaran,; Bandung, Indonesia.
Abstract:
OBJECTIVE: To determine feasibility, validity, and cost effectiveness of the syndromic approach to male patients with urethral discharge in Bandung, Indonesia. METHODS: The WHO algorithm on urethral discharge with no microscopy available was evaluated. Patients presented with a complaint of urethral discharge and if discharge was confirmed the algorithm was applied. Treatment covered gonococcal and chlamydial infection (ciprofloxacin 500 mg single oral dose plus doxycycline 100 mg, twice daily orally for 7 days). The gold standard for validation was gonococcal culture and chlamydia antigen detection. RESULTS: 140 male patients with a complaint of urethral discharge were enrolled; 119 had confirmed discharge and entered the decision tree: 107 were followed and 104 (97%) were clinically cured. Of the three patients with persistent discharge, one had a purulent urethral discharge, diagnosed as gonococcal urethritis and he was probably reinfected; two patients had a serous discharge and microbiological tests were negative. Overall, 106 out of 107 patients (99%) were microbiologically cured. Sensitivity of the algorithm is 100% and its positive predictive value (PPV) is 75% or 97% if validated against gold standard microbiological tests or Gram stain, respectively. Cost per patient is rupiah (Rp)5.894 ($US2.56) for the algorithm compared with Rp43.024 ($18.70) for full microbiological diagnosis. The cost estimate for an algorithm of urethral discharge with microscopy available is Rp6.432 ($2.80) CONCLUSION: The "symptom and sign" algorithm is fully adapted to the prevailing situation in primary healthcare settings, is acceptable to healthcare workers and patients (who are effectively treated at their first visit), is highly cost effective, is 100% sensitive (no false negatives, which is not the case with microbiological diagnosis), and has a high PPV, between 75% and 97%. It is an excellent patient management tool and a sound basis for partner notification so that it should have a major impact on STD/HIV control and prevention in both men and women.
Keywords: JOURNAL ARTICLE Administration, Oral Adolescence Adult *Algorithms Antibiotics, Combined/*THERAPEUTIC USE Bacteriological Techniques/ECONOMICS Chlamydia Infections/COMPLICATIONS/*DRUG THERAPY/ECONOMICS Ciprofloxacin/THERAPEUTIC USE Cost-Benefit Analysis Doxycycline/THERAPEUTIC USE Gonorrhea/COMPLICATIONS/*DRUG THERAPY/ECONOMICS Human Indonesia Male Middle Age Support, Non-U.S. Gov't Treatment Outcome Urethral Diseases/*DRUG THERAPY/ECONOMICS/MICROBIOLOGY 990530
A9950910
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Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.
