Tuberculosis meningitis in Hong Kong: experience in a regional hospital. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Tuberculosis meningitis in Hong Kong: experience in a regional hospital.

Int J Tuberc Lung Dis. 1998 Dec;2(12):1040-3. Unique Identifier : AIDSLINE MED/99084468
Mak W; Cheung RT; Ho SL; Tsang KL; Fong GC; Department of Medicine, Queen Mary Hospital, University of Hong; Kong, PRC.

Abstract: Tuberculous meningitis (TBM) remains common in Hong Kong. From January 1996 to June 1997, 11 adult patients with TBM presented to Queen Mary Hospital, a regional hospital in Hong Kong. The annual incidence of TBM was estimated at 1.8 per 100,000 population. Nine patients were local Chinese, and only one patient had the acquired immune-deficiency syndrome (AIDS). In contrast to the classical presentation as a chronic indolent disease, our patients presented acutely: the mean duration from onset of symptoms to presentation was 4.8 days (range 0-10). The most common presenting symptoms were headache (64%), fever (46%), or both (36%), with focal deficits occurring in 64% of patients. Cerebrospinal fluid (CSF) culture and polymerase chain reaction (PCR) were positive in 30% and 29% of cases. Mean CSF cell count, protein and glucose levels were 340 x 10(6)/L, 267 mg/dL, and 2.3 mmol/L, respectively. Extra-neural tuberculosis occurred in 46% of cases. All patients survived and responded to treatment. Drug-induced hepatotoxicity was common; 64% of patients developed biochemical hepatitis.
Keywords: JOURNAL ARTICLE Adult Aged Antitubercular Agents/THERAPEUTIC USE Female Hong Kong/EPIDEMIOLOGY Hospitals, Urban Human Incidence Male Middle Age Tuberculosis, Meningeal/DIAGNOSIS/DRUG THERAPY/*EPIDEMIOLOGYKWDjournalarticleadultagedantitubercularagents/therapeuticusefemalehongkong/epidemiologyhospitals,urbanhumanincidencemalemiddleagetuberculosis,meningeal/diagnosis/drugtherapy/KWDepidemiology
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A9950908

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