Apoptosis of Th1-like cells in experimental tuberculosis (TB). NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Apoptosis of Th1-like cells in experimental tuberculosis (TB).

Clin Exp Immunol. 1999 Feb;115(2):324-8. Unique Identifier : AIDSLINE MED/99132265
Das G; Vohra H; Saha B; Agrewala JN; Mishra GC; National Centre for Cell Sciences, Ganeshkhind, Pune 411007,; India.

Abstract: Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-gamma) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
Keywords: JOURNAL ARTICLE Animal Antigens, CD95/BIOSYNTHESIS *Apoptosis *Immunity, Cellular Interferon Type II/BIOSYNTHESIS Interleukin-2/BIOSYNTHESIS Interleukin-4/BIOSYNTHESIS Mice Mice, Inbred BALB C Mice, Inbred C3H Proto-Oncogene Proteins c-bcl-2/BIOSYNTHESIS *Th1 Cells Tuberculosis, Pulmonary/*IMMUNOLOGYKWDjournalarticleanimalantigens,cd95/biosynthesisKWDapoptosisKWDimmunity,cellularinterferontypeii/biosynthesisinterleukin-2/biosynthesisinterleukin-4/biosynthesismicemice,inbredbalbcmice,inbredc3hproto-oncogeneproteinsc-bcl-2/biosynthesisKWDth1cellstuberculosis,pulmonary/KWDimmunology
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