CD4/GP120mac251 interaction induces phospholipase A2 (PLA2) activation in cynomolgus monkey lymphocytes. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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CD4/GP120mac251 interaction induces phospholipase A2 (PLA2) activation in cynomolgus monkey lymphocytes.

J Med Primatol. 1998 Aug;27(4):193-201. Unique Identifier : AIDSLINE MED/99094469
Mavoungou E; Poaty-Mavoungou V; Unit of Immunology, International Center for Medical Research,; Franceville (CIRMF), Gabon. emavoung@cirmfrv.fr

Abstract: Cynomolgus monkey are susceptible to infection with select simian immunodeficiency virus (SIV). We investigated the early interactions between SIV envelope glycoproteins (gp120mac251) and macaque lymphocytes. Our results demonstrate that the soluble viral glycoprotein induce a specific phospholipase A2 (PLA2) activation in lymphocytes through CD4. This PLA2 activation, induced after envelope glycoprotein-CD4 interaction, because of its locally destabilizing membrane effect, may have important implications for preparing the lymphocyte membrane for fusion with the viral particle. However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation.
Keywords: JOURNAL ARTICLE Animal Antigens, CD4/*IMMUNOLOGY Female HIV Envelope Protein gp120/*IMMUNOLOGY Lymphocyte Transformation/IMMUNOLOGY Lymphocytes/*IMMUNOLOGY Macaca fascicularis/IMMUNOLOGY/VIROLOGY Male Monkey Diseases/IMMUNOLOGY Phospholipases A/*METABOLISM Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY Support, Non-U.S. Gov't SIV/*IMMUNOLOGYKWDjournalarticleanimalantigens,cd4/KWDimmunologyfemalehivenvelopeproteingp120/KWDimmunologylymphocytetransformation/immunologylymphocytes/KWDimmunologymacacafascicularis/immunology/virologymalemonkeydiseases/immunologyphospholipasesa/KWDmetabolismsimianacquiredimmunodeficiencysyndrome/immunologysupport,non-uKWDsKWDgov'tsiv/KWDimmunology
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