1999

Double gloving and a glove perforation indication system during the dental treatment of HIV-positive patients: are they necessary?: Br Dent J. 1999 Jan 9;186(1):27-9. Unique Identifier : AIDSLINE MED/99153115; Avery CM; Gallagher P; Birnbaum W; Department of Oral and Maxillofacial Surgery, King's College; Hospital, London.; AIM: The aim of this study was to compare the incidence of glove perforation when double gloved or single gloved during the routine treatment of HIV-positive patients. In addition, a glove perforation indication system based on a double gloving technique was assessed. DESIGN: Prospective, randomised and open study of
Hyperlipidaemia following treatment with protease inhibitors in patients with HIV-1 infection [letter]: Br J Clin Pharmacol. 1998 Nov;46(5):518-9. Unique Identifier : AIDSLINE MED/99049354; Churchill DR; Pym AS; Babiker AG; Back DJ; Weber JN
Phase III results of second-generation HIV protease inhibitor reported [news]: Oncology (Huntingt). 1998 Nov;12(11):1616. Unique Identifier : AIDSLINE MED/99052004
Lower genital tract neoplasia in women with HIV infection.: Oncology (Huntingt). 1998 Dec;12(12):1735-9; discussion 1742, 1745, 1747. Unique Identifier : AIDSLINE MED/99092006; Abercrombie PD; Korn AP; UCSF Department of Obstetrics, Gynecology, and Reproductive; Sciences, San Francisco General Hospital, California, USA.; Women who are infected with human immunodeficiency virus (HIV) are at greater risk for the development of lower genital tract neoplasia than are HIV-negative women. Among HIV-positive women, those who are more severely immunosuppressed appear to be at higher risk for cervical intraepithelial neoplasia (CIN), also know
Non-human immunodeficiency virus Kaposi's sarcoma can be effectively treated with low-dose interferon-alpha despite the persistence of herpesvirus-8.: Br J Dermatol. 1998 Dec;139(6):1052-4. Unique Identifier : AIDSLINE MED/99144182; Deichmann M; Thome M; Jackel A; Utermann S; Bock M; Waldmann V; Naher H; Department of Dermatology, Universitatsklinikum Heidelberg,; Germany.; Three patients, negative for human immunodeficiency virus (HIV), with histologically and polymerase chain reaction-proven non-HIV Kaposi s sarcoma who received low-dose interferon (IFN) as first-line treatment because of disseminated symptomatic disease are reported. Applying 3-18 million IU of IFN-alpha 2a per day, 3
Cutaneous mucinoses and HIV infection.: Br J Dermatol. 1998 Dec;139(6):1077-80. Unique Identifier : AIDSLINE MED/99144188; Rongioletti F; Ghigliotti G; De Marchi R; Rebora A; Department of Dermatology, University of Genoa, Italy.; In the last few years cutaneous mucinoses have been reported with increased frequency in HIV patients. We report the occurrence of scleredema, reticular erythematous mucinosis and lichen myxoedematosus in three different HIV-infected patients, review the literature and discuss the possible relationship between mucin d
Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression.: Hum Gene Ther. 1998 Nov 20;9(17):2459-68. Unique Identifier : AIDSLINE MED/99068402; Fassati A; Bardoni A; Sironi M; Wells DJ; Bresolin N; Scarlato G; Hatanaka M; Yamaoka S; Dickson G; Department of Biochemistry, Royal Holloway College, University of; London, Egham, Surrey, United Kingdom.; The use of retroviral vectors (RVs) derived from the murine oncoretroviruses for gene therapy is associated with the risk of malignant transformation of infected cells and ectopic expression of the proteins of interest. Targeting retroviral vectors to specific tissues would increase their safety and clinical applicabi
[Nutritional status of patients with HIV-AIDS infection (editorial)]: An Med Interna. 1998 Dec;15(12):623-6. Unique Identifier : AIDSLINE MED/99138541; Lopez-Herce JA
[Evolution of the nutritional status of patients with HIV-AIDS. Effects of socioeconomic situation and dietetic counseling]: An Med Interna. 1998 Dec;15(12):627-32. Unique Identifier : AIDSLINE MED/99138542; Sanchez Alvarez MC; Gomez Ramos MJ; Cano Sanchez A; Pacheco Guevara R; Nicolas Hernandez M; Garcia Alberola A; S. Medicina Intensiva-Unidad de Nutricion, Hospital General; Universitario, Murcia.; OBJECTIVES: To know HIV-AIDS patient s nutritional status in different infection s condition and their relation with the socioeconomic situation and, in that case, the nutritional condition improvement through the dietetic advice appropriated for each patient. METHODS: Prospective study of 79 patients with HIV-AIDS di
[Impact of HIV infection in hospital environment]: An Med Interna. 1998 Dec;15(12):633-7. Unique Identifier : AIDSLINE MED/99138543; Martinez Aviles P; Lopez Benito I; Berbegal Serra J; Servicio de Medicina Interna, Hospital Marina Alta, Denia,; Alicante.; OBJECTIVE: Retrospective study to review the admissions at the Hospital Marina Alta due to infection for HIV or its complications and look for risk factors. METHODS: Clinical charts of patients admitted at the hospital from 1989 to 1996 were analyzed. RESULTS: From 11,932 admissions, 199 (1.7%) were due to patients wi
[Study of histoenzymatic activity of isocitrate-DH in the hepatic tissue of rats treated with AZT: image analysis]: An Med Interna. 1998 Dec;15(12):638-41. Unique Identifier : AIDSLINE MED/99138544; Corcuera Pindado MT; Carbajo Perez S; Gomez Aguado F; Roldan Contreras M; Picazo Talavera A; Alonso Martin MJ; Servicio de Anatomia Patologica, Instituto de Salud Carlos III,; Madrid.; OBJECTIVE: Recently has been described alterations in different organs of HIV + patients treated with zidovudine ( AZT ), as secondary effect from drug administration. METHOD: We have developed and experimental rat model, in which the rats were administ
[Value of quantification of p24 antigen in plasma as a prognostic marker of survival in a cohort of 251 HIV-positive patients]: An Med Interna. 1998 Dec;15(12):647-9. Unique Identifier : AIDSLINE MED/99138546; Rubio Caballero M; Nogues Biau A; Falguera Sacrest M; Puig Gatnau T; Lorente L; Servicio de Medicina Interna, Hospital Universitario Arnau de; Vilanova, Lleida.; OBJECTIVE: To analyse plasma p24 antigen as a marker of survival in a cohort of HIV-infected patients whose time of seroconversion is unknown. DESIGN: Prospective cohort study. SETTING: AIDS Unit in a teaching hospital. PATIENTS: 251 patients were studied, most on antiretroviral therapy. Mean initial CD4 cell counts w
[Mucocutaneous manifestations in acute HIV infection. 3 case reports]: An Med Interna. 1998 Dec;15(12):650-3. Unique Identifier : AIDSLINE MED/99138547; Barnadas MA; Margall N; Rabella N; Alegre M; Baselga E; Randazzo L; de Moragas JM; Servicio de Dermatologia, Hospital de la Santa Creu i Sant Pau,; Barcelona.; We report three patients who developed a generalized rash with oral, genital or perianal ulcerations as a result of acute infection due to HIV. The primary infection was diagnosed by seroconversion (by means of EIA and Western blot techniques). Definitive diagnosis was established on days 52, 85 and 97 after the appea
[Pulmonary cryptosporidiosis and AIDS (letter)]: An Med Interna. 1998 Dec;15(12):672. Unique Identifier : AIDSLINE MED/99138554; Garcinuno Jimenez MA; Serrano-Heranz R; Barragan Casas JM; Moran Becares AY
Flow cytometric analysis of intracellular interferon-gamma synthesis in rat CD4 T cells.: Eur Cytokine Netw. 1998 Dec;9(4):613-8. Unique Identifier : AIDSLINE MED/99107682; Bernard I; Foucras G; Cautain B; van der Meide PH; Druet P; Guery JC; Saoudi JC; INSERM U. 28, place du Dr.-Baylac, 31059 Toulouse Cedex, France.; To date the techniques used to analyse cytokine expression by rat T cells do not give information about the simultaneous production of different cytokines from individual cells. Recently, a method for analysing the intracellular production of cytokines at the single cell level using flow cytometry has been developed.
[AIDS-related cancers]: Bull Cancer. 1999 Jan;86(1):53-6. Unique Identifier : AIDSLINE MED/99155365; Blay JY; Bouhour D; Unite cytokine et cancer, Inserm U. 453, Centre Leon-Berard,; 28, rue Laennec, 69008 Lyon, France.
Protease inhibitors in HIV infection. Lipodystrophy may be a consequence of prolonged survival [letter]: BMJ. 1999 Jan 9;318(7176):122. Unique Identifier : AIDSLINE MED/99096749; Buss N; Duff F
US considers name based tracking for HIV positive patients [news]: BMJ. 1999 Jan 9;318(7176):75. Unique Identifier : AIDSLINE MED/99096721; Ciment J
Medical students, their electives, and HIV [editorial; comment]: BMJ. 1999 Jan 16;318(7177):139-40. Unique Identifier : AIDSLINE MED/99105842; Wilkinson D; Symon B
Medical students' risk of infection with bloodborne viruses at home and abroad: questionnaire survey [see comments]: BMJ. 1999 Jan 16;318(7177):158-60. Unique Identifier : AIDSLINE MED/99105866; Gamester CF; Tilzey AJ; Banatvala JE; Guy's, King's College, and St Thomas's School of Medicine, St; Thomas's Campus, London SE1 7EH.; OBJECTIVE: To determine risks of exposure to and prevention of bloodborne virus infections among medical students during their elective period. DESIGN: Questionnaire study of students returning from their electives in 1997-8. SETTING: Urban teaching hospital. SUBJECTS: 220 final year medical students. RESULTS: 148 stu
Provision of health advice for UK medical students planning to travel overseas for their elective study period: questionnaire survey [see comments]: BMJ. 1999 Jan 16;318(7177):161-2. Unique Identifier : AIDSLINE MED/99105867; Moss PJ; Beeching NJ; Division of Tropical Medicine, Liverpool School of Tropical; Medicine, Liverpool L3 5QA.
Sexual lifestyle of long distance lorry drivers in India: questionnaire survey.: BMJ. 1999 Jan 16;318(7177):162-3. Unique Identifier : AIDSLINE MED/99105868; Rao KS; Pilli RD; Rao AS; Chalam PS; AIDS Prevention Division, Child Foundation of India,; Visakhapatnam 530 008, Andhra Pradesh, India.
Abdominal findings in AIDS-related pulmonary tuberculosis correlated with associated CD4 levels [see comments]: Abdom Imaging. 1998 Nov-Dec;23(6):573-7. Unique Identifier : AIDSLINE MED/99119249; Solomon A; Feldman C; Kobilski SA; Department of Diagnostic Radiology, University of Witwatersrand,; Parktown, South Africa.; BACKGROUND: To document the abdominal manifestations of tuberculosis (TB) associated with human immunodeficiency virus (HIV) infection and to correlate those findings with CD4 levels. METHODS: Twenty-nine HIV-positive patients with culture-proven Mycobacterium tuberculosis infection were entered into the study. Chest
Abdominal findings in AIDS-related pulmonary tuberculosis correlated with associated CD4 levels [comment]: Abdom Imaging. 1998 Nov-Dec;23(6):578-9. Unique Identifier : AIDSLINE MED/99119250; Wall SD; Edinburgh KJ; Department of Radiology, University of California, San Francisco; 94121, USA.
HTLV-I infection among relatives of patients with adult T-cell leukemia/lymphoma in Brazil: analysis of infection transmission.: Leuk Lymphoma. 1998 Oct;31(3-4):411-6. Unique Identifier : AIDSLINE MED/99084551; Borducchi DM; Oliveira JS; Bordin JO; Kerbauy J; The Hematology and Transfusion Medicine Service-Universidade; Federal de Sao Paulo, Escola Paulista de Medicina, Brazil.; We examined the presence of HTLV-I infection among 66 family members of 13 patients with well documented ATL to investigate the routes of HLTV-I transmission in a Southeast region of Brazil . HTLV-I infection was screened by an enzyme immunossay (ELISA) test and all repeatedly posit
Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium.: Protein Sci. 1998 Dec;7(12):2669-74. Unique Identifier : AIDSLINE PDB/R1WJEMR; Cai M; Huang Y; Caffrey M; Zheng R; Craigie R; Clore GM; Gronenborn AM; Laboratory of Chemical Physics, National Institute of Diabetes; and Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0520, USA.; The solution structure of His12 --> Cys mutant of the N-terminal zinc binding domain (residues 1-55; IN(1-55)) of HIV-1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very similar to that of the wild-type N-terminal domain complexed to zinc.
Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds.: Biol Pharm Bull. 1998 Nov;21(11):1154-9. Unique Identifier : AIDSLINE MED/99068293; Hayakawa Y; Fujii H; Hase K; Ohnishi Y; Sakukawa R; Kadota S; Namba T; Saiki I; Department of Pathogenic Biochemistry, Research Institute for; Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.; We have investigated the anti-metastatic effect of Celosia argentea seed extracts (CAE), which have traditionally been used as a therapeutic drug for eye and hepatic diseases in China and Japan . Intraperitoneal (i.p.) administration of CAE for 7 d
Minimizing HIV/AIDS malnutrition.: Medsurg Nurs. 1998 Oct;7(5):256-67; quiz 268-9. Unique Identifier : AIDSLINE MED/99155452; Keithley JK; Swanson B; Rush University College of Nursing, Chicago, IL, USA.; HIV/AIDS malnutrition influences immune function, disease progression, and quality of life. Changes in dietary intake, altered metabolism, and malabsorption are among the mechanisms that contribute to the nutritional alterations seen in HIV/AIDS. Medical-surgical nurses can help their patients minimize HIV/AIDS malnut
[Questions about sexual ethics related to AIDS]: Contracept Fertil Sex. 1998 Nov;26(11):812-8. Unique Identifier : AIDSLINE MED/99082408; Colpin H; Centre de Reference Sida-ULB, CHU Saint-Pierre, Bruxelles,; Belgique.; The discovery of Aids has profoundly interfered with the sexual behaviour, perceptions and discourse. It has provoked new questions in the field of sexual ethics, some of which are presented and discussed here: safer sex, partner notification, child wish and the attitude of society towards Aids. Finally a discussion o
New UK guidance on the prevention and control of transmission of HIV related and drug resistant tuberculosis.: Commun Dis Rep CDR Wkly. 1999 Feb 5;9(6):49. Unique Identifier : AIDSLINE MED/99148891
Proton MR spectroscopy in inflammatory and infectious brain disorders.: Neuroimaging Clin N Am. 1998 Nov;8(4):863-80. Unique Identifier : AIDSLINE MED/98443341; Cecil KM; Lenkinski RE; Department of Radiology, MR Section, University of Pennsylvania,; Philadelphia 19104, USA. kim@mrssparc.mri.upenn.edu; This article reviews the proton MR spectroscopy literature regarding brain infarction and inflammatory diseases. We examine the salient findings reported for bacterial abscesses, intracranial tuberculomas, Creutzfeldt-Jakob disease, herpes simplex encephalitis and HIV. These processes demonstrate specific metabolic pr
Evidence for a synergistic effect of the HIV-1 envelope protein gp120 and brain-derived neurotrophic factor (BDNF) leading to enhanced expression of somatostatin neurons in aggregate cultures derived from the human fetal cortex.: Brain Res. 1999 Jan 9;815(2):349-57. Unique Identifier : AIDSLINE MED/99096587; Barnea A; Roberts J; Ho RH; Department of Obstetrics and Gynecology, The University of Texas; Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd.,; Dallas, TX 75235-9032, USA. abarn1@mednet.swmed.edu; Changes in the expression of somatostatin (SRIF) have been observed in the brains of HIV encephalitis. Since gp120 is thought to play a major role in AIDS-associated abnormalities in the brain, we addressed the question: Does gp120 alter the functional expression of human fetal SRIF neurons in culture and if so, is th
Neurotoxicity of FIV and FIV envelope protein in feline cortical cultures.: Brain Res. 1999 Jan 23;816(2):431-7. Unique Identifier : AIDSLINE MED/99096653; Bragg DC; Meeker RB; Duff BA; English RV; Tompkins MB; Curriculum in Neurobiology and Department of Neurology,; University of North Carolina, Chapel Hill, NC 27599, USA.; The neurotoxic effects of the feline immunodeficiency virus (FIV) and FIV envelope proteins were measured in primary cultures of feline cortical neurons. Envelope protein from the FIV-PPR strain promoted neuronal swelling and death, whereas envelope protein from the FIV-34TF10 isolate produced intermediate or negligib
Occupational exposure to HIV: experience at a tertiary care center.: J Occup Environ Med. 1998 Dec;40(12):1102-9. Unique Identifier : AIDSLINE MED/99089053; Swotinsky RB; Steger KA; Sulis C; Snyder S; Craven DE; Department of Medicine, Boston University School of Medicine,; Mass, USA.; We examined our hospital-based occupational health clinic s experience with combination antiretroviral therapy for postexposure prophylaxis for human immunodeficiency virus (HIV). Over a 12-month period, 68 workers started postexposure prophylaxis: 23 with zidovudine and lamivudine and 45 with zidovudine, lamivudine,
[Acquired immunodeficiency syndrome]: Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):269-72. Unique Identifier : AIDSLINE MED/99050683; Kawano F; Sanada I; Institute for Clinical Research, Kumamoto National Hospital.
[Job's syndrome]: Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):76-8. Unique Identifier : AIDSLINE MED/99050627; Asano Y; Niho Y; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University.
Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients.: Eur J Oral Sci. 1998 Dec;106(6):979-85. Unique Identifier : AIDSLINE MED/99094517; Grimoud AM; Arnaud C; Dellamonica P; Lodter JP; Laboratory for Oro-Facial Biology, Faculty of Dentistry, Toulouse; III University and Hotel Dieu, University Hospital, France.; doydenta@adm.ups-tlse.fr; The objective of this study was to determine the relationships between saliva protein concentrations, oral mucosal lesions, and systemic parameters in HIV positive patients and controls. Twenty-three control volunteers and 58 HIV-antibody positive patients received a complete oral examination and medical evaluation. I
Angiocentric CD3(+) T-cell infiltrates in human immunodeficiency virus type 1-associated central nervous system disease in children.: Clin Diagn Lab Immunol. 1999 Jan;6(1):105-14. Unique Identifier : AIDSLINE MED/99091889; Katsetos CD; Fincke JE; Legido A; Lischner HW; de Chadarevian JP; Kaye EM; Platsoucas CD; Oleszak EL; Department of Microbiology and Immunology, St. Christopher's; Hospital for Children and Allegheny University of the Health; Sciences, Philadelphia, Pennsylvania, USA.; A significant proportion of brain tissue specimens from children with AIDS show evidence of vascular inflammation in the form of transmural and/or perivascular mononuclear-cell infiltrates at autopsy. Previous studies have shown that in contrast to inflammatory lesions observed in human immunodeficiency virus type 1 (
Giant syncytia and virus-like particles in ovarian carcinoma cells isolated from ascites fluid.: Clin Diagn Lab Immunol. 1999 Jan;6(1):115-26. Unique Identifier : AIDSLINE MED/99091890; Rakowicz-Szulczynska EM; McIntosh DG; Smith ML; Departments of Obstetrics and Gynecology, University of Nebraska; Medical Center, Omaha, Nebraska 68198-3255, USA.; emrakoii@unmc.edu; Ovarian cancer cells were isolated from ascites fluid of 30 different patients diagnosed with cystadenocarcinoma of ovaries. Large colonies of malignant ASC cells were observed during the first week of cell growth in vitro. Colony formation was followed by fusion of cells and formation of large multinucleated and high
Viability and recovery of peripheral blood mononuclear cells cryopreserved for up to 12 years in a multicenter study.: Clin Diagn Lab Immunol. 1999 Jan;6(1):14-9. Unique Identifier : AIDSLINE MED/99091873; Kleeberger CA; Lyles RH; Margolick JB; Rinaldo CR; Phair JP; Giorgi JV; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, Maryland 21205, USA. ckleeber@jhsph.edu; The Multicenter AIDS Cohort Study (MACS), an ongoing prospective study of the natural history of human immunodeficiency virus (HIV), has stored biologic specimens, including peripheral blood mononuclear cells (PBMC), from 5,622 participants for up to 12 years. The purpose of the present analysis was to evaluate the qu
Incidence of human immunodeficiency virus antibody in a prenatal population at a community hospital.: Clin Diagn Lab Immunol. 1999 Jan;6(1):140-1. Unique Identifier : AIDSLINE MED/99091895; Alexander TS; Lee J; Yen-Lieberman B; Department of Pathology and Laboratory Medicine, Summa Health; System, Akron, Ohio 44304, USA. alexandt@summa-health.org; Prenatal human immunodeficiency virus (HIV) screening may reduce vertical HIV transmission. We screened 4,419 prenatal sera and found 38 repeatedly reactive specimens with an HIV-1-HIV-2 enzyme-linked immunosorbent assay. Western blot analysis confirmed four of these specimens as positive for HIV-1 antibodies. Screeni
Immune determinants of organism and outcome in febrile hospitalized Thai patients with bloodstream infections.: Clin Diagn Lab Immunol. 1999 Jan;6(1):73-8. Unique Identifier : AIDSLINE MED/99091883; Jason J; Archibald L; McDonald LC; Hart WM; Rheanppumikankit S; Tansuphwaswadikul S; Byrd MG; Larned J; Han A; Green TA; Jarvis WR; Immunology Branch, Sexually Transmitted Diseases, and; Tuberculosis Laboratory Research, National Center for Infectious; Diseases Centers for Disease Control and Prevention, Public; Health Service, Atlanta, Georgia 30333, USA. JMJ1@CDC.gov; Opportunistic infections (OI) and the human immunodeficiency virus (HIV) cause significant morbidity and mortality in developing countries. Immune cell and cytokine profiles may be related to the type and course of OI and to the OI-HIV interaction. Examining cell-specific cytokine production ex vivo has only recently
Variables that affect assays for plasma cytokines and soluble activation markers.: Unique Identifier : AIDSLINE MED/99091886
Potentiation of E7 antisense RNA-induced antitumor immunity by co-delivery of IL-12 gene in HPV16 DNA-positive mouse tumor.: Gene Ther. 1998 Nov;5(11):1462-71. Unique Identifier : AIDSLINE MED/99129160; He YK; Lui VW; Baar J; Wang L; Shurin M; Almonte C; Watkins SC; Huang L; Department of Pharmacology, University of Pittsburgh, School of; Medicine, PA 15261, USA.; Down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied, and in some cases, therapeutic effects have been demonstrated. We have previously shown that down-regulation of HPV16 E6 and E7 gene expression inhibited HPV DNA-positive C3 mouse tumor growth. Although not all of the
Shapes of MHC restriction.: Immunity. 1999 Jan;10(1):1-7. Unique Identifier : AIDSLINE MED/99146370; Garboczi DN; Biddison WE; Structural Biology Section, National Institute of Allergy and; Infectious Diseases, Rockville, Maryland 20852-1727, USA.; dgarboczi@atlas.niaid.nih.gov
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.: Immunity. 1999 Jan;10(1):127-36. Unique Identifier : AIDSLINE GENBANK/AF110460; Novick D; Kim SH; Fantuzzi G; Reznikov LL; Dinarello CA; Rubinstein M; Department of Molecular Genetics, Weizmann Institute of Science,; Rehovot, Israel.; An interleukin-18 binding protein (IL-18BP) was purified from urine by chromatography on IL-18 beads, sequenced, cloned, and expressed in COS7 cells. IL-18BP abolished IL-18 induction of interferon-gamma (IFNgamma), IL-8, and activation of NF-kappaB in vitro. Administration of IL-18BP to mice abrogated circulating IFN
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.: Immunity. 1999 Jan;10(1):39-49. Unique Identifier : AIDSLINE MED/99146374; Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I; Akira S; Department of Biochemistry, Hyogo College of Medicine,; Nishinomiya, Japan.; We have generated mice with a cell type-specific disruption of the Stat3 gene in macrophages and neutrophils. The mutant mice are highly susceptible to endotoxin shock with increased production of inflammatory cytokines such as TNF alpha, IL-1, IFN gamma, and IL-6. Endotoxin-induced production of inflammatory cytokine
RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.: Unique Identifier : AIDSLINE MED/99146379; Song A; Chen YF; Thamatrakoln K; Storm TA; Krensky AM; Department of Pediatrics, Stanford University School of Medicine,; California 94305-5208, USA.; RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression clo
[Effect of HIV envelope glycoprotein on the induction of immune dysregulation in HIV infection]: Nihon Rinsho Meneki Gakkai Kaishi. 1998 Feb;21(1):11-9. Unique Identifier : AIDSLINE MED/99100284; Sekigawa I; Akimoto H; Kaneko H; Department of Medicine, Juntendo Izu-Nagaoka Hospital, Juntendo; University School of Medicine.; The envelope glycoprotein of human immunodeficiency virus (HIV) has been know to play an important role in the induction of immune dysregulation of HIV infection. Recent evidence suggests that HIV requires the chemokine receptors as a coreceptor. In addition, we found that HIV-2 (but not HIV-1) envelope glycoprotein c
Bacterial extract OM85-BV induces interleukin-12-dependent IFN-gamma production by human CD4+ T cells.: J Interferon Cytokine Res. 1998 Oct;18(10):817-21. Unique Identifier : AIDSLINE MED/99025488; Byl B; Libin M; Gerard M; Clumeck N; Goldman M; Mascart-Lemone F; Department of Immunology, Hopital Erasme, Brussels, Belgium.; To obtain insight into the possible mode of action of bacterial extracts used as immunostimulants in Europe, we used the ELISPOT technique to investigate the effects of one of them (OM85-BV, Broncho-Vaxom) on interferon-y (IFN-gamma) production by peripheral blood mononuclear cells (PBMC). We found that (1) OM85-BV st
[Incidence and clinical features of splenic abscesses, with special reference to tuberculous etiology in a general hospital]: Gastroenterol Hepatol. 1998 Dec;21(10):479-82. Unique Identifier : AIDSLINE MED/99126753; Arruabarrena I; Bermejo MC; Ojeda E; Cosme A; Garmendia G; Servicio de Medicina Interna, Hospital Nuestra Senora de; Aranzazu, San Sebastian.; BACKGROUND: The aim of this revision is to know the incidence of splenic abscess (SA) in our hospital, its etiology, with special reference to tuberculosis, and clinical characteristics. PATIENTS AND METHODS: Abdominal CT-scan performed during the period 1987-1997, with the diagnosis of splenic abscess were reviewed.
[How should a patient with chronic hepatitis C be advised?]: Gastroenterol Hepatol. 1998 Nov;21(9):459-63. Unique Identifier : AIDSLINE MED/99099392; Bruguera M; Hospital Clinic i Provincial, Departamento de Medicina, Facultad; de Medicina, Universidad de Barcelona.
Changes in mortality, arrests, and hospitalizations in nonvoluntarily treated heroin addicts in relation to methadone treatment.: Subst Use Misuse. 1998 Dec;33(14):2803-17. Unique Identifier : AIDSLINE MED/99084790; Fugelstad A; Agren G; Romelsjo A; Center for Dependency Disorders of St. Goran's Hospital,; Stockholm, Sweden.; This study analyzes the mortality, hospitalizations, and arrests in a cohort of severe intravenous heroin users divided into three groups: those in methadone treatment, those discharged from treatment, and those who never received treatment. The study population consists of 101 heroin users, of whom 56 were HIV-seropo
The impact of methadone on consumption of inpatient care and mortality, with special reference to HIV status.: Subst Use Misuse. 1998 Dec;33(14):2819-34. Unique Identifier : AIDSLINE MED/99084791; Stenbacka M; Leifman A; Romelsjo A; Department of Clinical Neuroscience, Center for Clinic of; Dependence Disorders, Karolinska Institute, Stockholm, Sweden.; This study investigates the impact of methadone treatment on inpatient care admissions and mortality among 331 methadone-maintained patients compared with 1,483 similar untreated opiate misusers. The methadone patients manifested a lower mortality during treatment than the comparison group and those patients who had l
Induction of the chemokine beta peptides, MIP-1 alpha and MIP-1 beta, by lipopolysaccharide is differentially regulated by immunomodulatory cytokines gamma-IFN, IL-10, IL-4, and TGF-beta.: Mol Med. 1998 Oct;4(10):648-57. Unique Identifier : AIDSLINE MED/99064547; Sherry B; Espinoza M; Manogue KR; Cerami A; Picower Institute for Medical Research, Manhasset, New York, USA.; bsherry@picower.edu; The macrophage occupies a central role in the host response to invasion, exerting its control over the developing inflammatory response largely through the elaboration of an assortment of endogenous mediators including many cytokines. The beta chemokine peptides, macrophage inflammatory protein [MIP]-1 alpha and MIP-1
[Lack of air conditioning and mycotoxin poisoning are basic co-factors in tropical spastic paraparesis]: Rev Neurol. 1998 Apr;26(152):564-7. Unique Identifier : AIDSLINE MED/99012098; Leon FE; Carpintero M; Bayona J; Gaffga N; Ocampo L; del Castillo N; Department of Neurology, University of Alabama at Birmingham,; USA.; INTRODUCTION: Chronic idiopathic spastic paraparesis (CHISPA) have been associated to HTLV-I virus infection, and unknown environmental factors have been suggested to play a role in its pathogenesis. METHOD: Based in our previous studies we wanted to know if the lack of refrigerators and the mycotoxin contamination of
Protease inhibitors, diabetes mellitus and blood lipids.: Diabetes Metab. 1998 Dec;24(6):547-9. Unique Identifier : AIDSLINE MED/99131015; Meyer L; Rabaud C; Ziegler O; May T; Drouin P; Service de Diabetologie, CHU Nancy, France.; We report the case of a patient with human immunodeficiency virus (HIV) and no familial or personal history of metabolic disease, who experienced two diabetes decompensations (severe hyperglycaemia without ketonuria) associated with severe hypertriglyceridaemia, after the introduction of
Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES.: Chem Biol. 1999 Jan;6(1):43-51. Unique Identifier : AIDSLINE MED/99111238; Wilken J; Hoover D; Thompson DA; Barlow PN; McSparron H; Picard L; Wlodawer A; Lubkowski J; Kent SB; Gryphon Sciences, 250 East Grand Avenue, Suite 90, South San; Francisco,CA 94080, USA.; BACKGROUND: RANTES is a CC-type chemokine protein that acts as a chemoattractant for several kinds of leukocytes, playing an important pro-inflammatory role. Entry of human immunodeficiency virus-1 (HIV-1) into cells depends on the chemokine receptor CCR5. RANTES binds CCR5 and inhibits HIV-1 entry into peripheral blo
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.: Cancer Res. 1999 Feb 15;59(4):940-6. Unique Identifier : AIDSLINE MED/99151546; Sun XL; Jayaram HN; Gharehbaghi K; Li QJ; Xiao X; Antony AC; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202, USA.; Cervical carcinoma is an AIDS-defining illness. The expression of folate receptors (FRs) in cervical carcinoma (HeLa-IU1) cells was modulated by stable transduction of FR cDNA encapsidated in recombinant adeno-associated virus-2 in the sense and antisense orientation (sense and antisense cells, respectively). Although
Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma.: Cancer Res. 1999 Feb 15;59(4):975-81. Unique Identifier : AIDSLINE MED/99151551; Nagaoka Y; Kabeya H; Onuma M; Kasai N; Okada K; Aida Y; Tsukuba Life Science Center, The Institute of Physical and; Chemical Research (RIKEN), Ibaraki, Japan.; For the further characterization of bovine leukemia virus (BLV)-induced leukemogenesis, we investigated the association between polymorphism of ovine leukocyte antigen (OLA)-DRB1 gene and tumor development after infection of sheep with BLV. We infected 28 sheep with BLV and cloned exon 2 of the OLA-DRB1 gene from asym
Observations from the CDC. The urgent need for new HIV/STD prevention options for women.: J Womens Health. 1998 Nov;7(9):1081-6. Unique Identifier : AIDSLINE MED/99078576; Irwin K; Scarlett M; Moseley R; Division of STD Prevention, National Center for HIV, STD, and TB; Prevention, Atlanta, Georgia, USA.
Augmentation of therapeutic antitumor immunity by B16F10 melanoma cells transfected by interferon-gamma and allogeneic MHC class I cDNAs.: Mol Cells. 1998 Oct 31;8(5):629-36. Unique Identifier : AIDSLINE MED/99072173; Lim YS; Kang BY; Kim EJ; Kim SH; Hwang SY; Kim TS; College of Pharmacy, Chonnam National University, Kwangju, Korea.; The cDNAs for interferon-gamma (IFN-gamma) and allogeneic H-2Kd molecules were transfected into highly metastatic B16F10 melanoma cells (H-2b), and the synergistic effects of the antitumor immune responses by the doubly transfected cells (B16/Kd/IFN-gamma cells) were investigated in C57BL/6 mice (H-2b). The singly tra
The risk of occupational exposure and infection with infectious diseases: Part 2.: Home Care Provid. 1998 Dec;3(6):304-5. Unique Identifier : AIDSLINE MED/99154476; Sharbaugh RJ; drbob6@aol.com; This article is the second of a series devoted to the epidemiology of selected infectious diseases known to be transmitted in health care settings. In subsequent issues, the relative risk of occupational exposure to and infection with these diseases will be discussed. Part 1 (October 1998 Home Care Provider) consisted
Solution structure of peptides from HIV-1 Vpr protein that cause membrane permeabilization and growth arrest.: J Pept Sci. 1998 Nov;4(7):426-35. Unique Identifier : AIDSLINE MED/99066695; Yao S; Torres AM; Azad AA; Macreadie IG; Norton RS; Biomolecular Research Institute, Parkville, Victoria, Australia.; Vpr, one of the accessory gene products encoded by HIV-1, is a 96-residue protein with a number of functions, including targeting of the viral pre-integration complex to the nucleus and inducing growth arrest of dividing cells. We have characterized by 2D NMR the solution conformations of bioactive synthetic peptide f
Biological and conformational studies on analogues of a synthetic peptide enhancing HIV-1 infection.: J Pept Sci. 1998 Nov;4(7):436-48. Unique Identifier : AIDSLINE MED/99066696; Dettin M; Scarinci C; Zanotto C; Roncon R; De Rossi A; Di Bello C; Department of Chemical Process Engineering, University of Padua,; Italy. peptide@uxl.unipd.it; We have previously demonstrated that a 23-amino acid peptide derived from the V3 loop of the surface glycoprotein of the HIV-1 strain MN is able to bind CD4 and to enhance HIV-1 infection. Further studies have suggested that the peptide/CD4 interaction induces an increase in both CD4 expression and CD4/gp120 binding a
Prospective evaluation of a flow chart using a risk assessment for the diagnosis of STDs in primary healthcare centres in Libreville, Gabon.: Sex Transm Infect. 1998 Jun;74 Suppl 1:S128-32. Unique Identifier : AIDSLINE MED/99147444; Bourgeois A; Henzel D; Dibanga G; Malonga-Mouelet G; Peeters M; Coulaud JP; Fransen L; Delaporte E; Institut de Medecine et d'Epidemiologie Africaines, CHU; Bichat-C Bernard, Paris, France.; BACKGROUND: The serious impact of STDs on women and children in particular, and the linkage between STDs and HIV infection are a profound concern to public health worldwide. One of the main strategies against STDs is based on early diagnosis and treatment. However, this approach is limited by the lack of appropriate l
Evaluation of syndromic patient management algorithm for urethral discharge.: Sex Transm Infect. 1998 Jun;74 Suppl 1:S29-33. Unique Identifier : AIDSLINE MED/99147431; Djajakusumah T; Sudigdoadi S; Keersmaekers K; Meheus A; Department of Dermatovenereology, Universitas Padjadjaran,; Bandung, Indonesia.; OBJECTIVE: To determine feasibility, validity, and cost effectiveness of the syndromic approach to male patients with urethral discharge in Bandung, Indonesia . METHODS: The WHO algorithm on urethral discharge with no microscopy available was evaluated. Patients presented with a
Reproductive tract infections in primary healthcare, family: Unique Identifier : AIDSLINE MED/99147439
Tuberculosis meningitis in Hong Kong: experience in a regional hospital.: Int J Tuberc Lung Dis. 1998 Dec;2(12):1040-3. Unique Identifier : AIDSLINE MED/99084468; Mak W; Cheung RT; Ho SL; Tsang KL; Fong GC; Department of Medicine, Queen Mary Hospital, University of Hong; Kong, PRC.; Tuberculous meningitis (TBM) remains common in Hong Kong . From January 1996 to June 1997, 11 adult patients with TBM presented to Queen Mary Hospital, a regional hospital in Hong Kong. The annual incidence of TBM was estimated at 1.
Management of pulmonary tuberculosis suspects with negative sputum smears and normal or minimally abnormal chest radiographs in resource-poor settings.: Int J Tuberc Lung Dis. 1998 Dec;2(12):999-1004. Unique Identifier : AIDSLINE MED/99084461; Harries AD; Banda HT; Boeree MJ; Welby S; Wirima JJ; Subramanyam VR; Maher D; Nunn P; Department of Medicine, College of Medicine, Blantyre, Malawi.; SETTING: Queen Elizabeth Central Hospital, Blantyre, Malawi . OBJECTIVES: 1) To determine the proportion of pulmonary tuberculosis (PTB) suspects with negative sputum smears and a normal/minimally abnormal chest radiograph (CXR) who are culture-positive for Mycobacterium tuberculosi
Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block copolymer adjuvant in patients with advanced cancer.: Clin Cancer Res. 1997 Dec;3(12 Pt 1):2355-62. Unique Identifier : AIDSLINE MED/99111192; Triozzi PL; Stevens VC; Aldrich W; Powell J; Todd CW; Newman MJ; The Ohio State University Comprehensive Cancer Center, 410 West; 10th Ave, Columbus, Ohio 43210, USA.; The clinical and immunological effects of a vaccine consisting of CTP37, a synthetic peptide corresponding to the COOH-terminal peptide (CTP) of beta-human chorionic gonadotropin (beta-hCG) conjugated to diphtheria toxoid, combined with CRL 1005, a novel synthetic nonionic block copolymer adjuvant, were examined. Twen
AIDS and mental health--Part I.: Harv Ment Health Lett. 1999 Mar;15(9):1-4 cont. Unique Identifier : AIDSLINE MED/99154416
Signals that regulate the host response to Mycobacterium tuberculosis.: Novartis Found Symp. 1998;217:145-57; discussion 157-9. Unique Identifier : AIDSLINE MED/99134965; Beyers AD; van Rie A; Adams J; Fenhalls G; Gie R; Beyers N; MRC Centre for Molecular and Cellular Biology, Faculty of; Medicine, University of Stellenbosch, Tygerberg, South Africa.; An appropriate T helper (Th) 1 immune response is required for the elimination of Mycobacterium tuberculosis. The factors regulating the polarization of mouse or human T cells to produce Th1 or Th2 cytokines are briefly reviewed. These factors include host genetics, cytokines present at the site of T cell activation,
Using conventional and molecular epidemiological analyses to target tuberculosis control interventions in a low incidence area.: Novartis Found Symp. 1998;217:42-54; discussion 54-6. Unique Identifier : AIDSLINE MED/99134959; Hopewell PC; Division of Pulmonary and Critical Care Medicine, San Francisco; General Hospital, CA 94110, USA.; To consolidate the gains made in controlling tuberculosis in industrialized countries in the past five years, we must analyse carefully the epidemiology of the disease and the effectiveness of various control interventions. In San Francisco we have performed conventional and molecular epidemiological analyses that hav
Immunological and endocrinological characteristics of tuberculosis that provide opportunities for immunotherapeutic intervention.: Unique Identifier : AIDSLINE MED/99134961; Rook GA; Hernandez-Pando R; Immunity to tuberculosis requires a T helper 1 (Th1) response which can be compromised by excessive release of inflammatory cytokines or Th2 activity. Environmental saprophytes can protect against tuberculosis by inducing Th1 recognition of the common antigens, or make mice more susceptible to tuberculosis than unimmu
In vitro activity of terbinafine against clinical isolates of dermatophytes.: Med Mycol. 1998 Aug;36(4):235-7. Unique Identifier : AIDSLINE MED/99102707; Arzeni D; Barchiesi F; Compagnucci P; Cellini A; Simonetti O; Offidani AM; Scalise G; Istituto di Malattie Infettive e Medicina Pubblica, Universita; degli Studi di Ancona, Italy.; A broth macrodilution method following the recommendations established by the National Committee for Clinical Laboratory Standards was employed for testing terbinafine against 20 clinical isolates of dermatophytes belonging to seven species. The minimal inhibitory concentrations resulting in either 80% or 100% inhibit
Comments on Microsporum canis [letter]: Med Mycol. 1998 Aug;36(4):247-8. Unique Identifier : AIDSLINE MED/99102710; Mancianti F
Flow injection with chemical reaction interface-isotope ratio mass spectrometry: an alternative to off-line combustion for detecting low levels of enriched 13C in mass balance studies.: J Am Soc Mass Spectrom. 1999 Feb;10(2):153-8. Unique Identifier : AIDSLINE MED/99125230; Chen P; Teffera Y; Black GE; Abramson FP; Department of Pharmacology, George Washington University School; of Medicine and Health Sciences, Washington, DC 20037, USA.; We have evaluated the potential of flow injection chemical reaction interface isotope-ratio mass spectrometry to replace radioactive labeling techniques in material balance studies. A sample is flow injected and transmitted through a desolvation system followed by combustion to form 13CO2 with a microwave-powered chem
Identification of in vitro metabolites of Indinavir by "intelligent automated LC-MS/MS" (INTAMS) utilizing triple quadrupole tandem mass spectrometry.: J Am Soc Mass Spectrom. 1999 Feb;10(2):175-83. Unique Identifier : AIDSLINE MED/99125232; Yu X; Cui D; Davis MR; Department of Drug Metabolism, Merck Research Laboratories, West; Point, Pennsylvania, USA.; In an effort to improve the efficiency of the TSQ 7000 LC-MS/MS system for identification of drug metabolites in biological matrices in support of drug discovery programs, a combination of instrument control language procedures for the Finnigan MAT TSQ 7000 mass spectrometer, referred to as INTAMS, were composed. INTA
The human polyomavirus, JCV, and neurological diseases (review).: Int J Mol Med. 1998 Apr;1(4):647-55. Unique Identifier : AIDSLINE MED/99074470; Gordon J; Khalili K; Center for NeuroVirology and NeuroOncology, Allegheny University; of the Health Sciences, Broad and Vine, MS 406, Philadelphia, PA; 19102, USA.; JC virus, a human neurotropic polyomavirus, is the established etiologic agent of the fatal demyelinating disease, progressive multifocal leukoencephalopathy, which usually affects individuals with defects in cell-mediated immunity. Cytolytic destruction of oligodendrocytes, the myelin-producing cells of the central n
IgG subclass reactivity to human cardiac myosin in cardiomyopathy patients is indicative of a Th1-like autoimmune disease.: Clin Exp Immunol. 1999 Feb;115(2):236-47. Unique Identifier : AIDSLINE MED/99132253; Skyllouriotis P; Skyllouriotis-Lazarou M; Natter S; Steiner R; Spitzauer S; Kapiotis S; Valent P; Hirschl AM; Guber SE; Laufer G; Wollenek G; Wolner E; Wimmer M; Valenta R; General & Experimental Pathology, Vienna General Hospital,; University of Vienna, Medical School, Vienna, Austria.; Studies performed in mice together with the demonstration of increased levels of heart-specific autoantibodies, cytokines and cytokine receptors in sera from cardiomyopathy (CMP) patients argued for a pathogenic role of autoimmune mechanisms in CMP. This study was designed to analyse the presence of IgG anti-heart ant
Mechanisms of Mycobacterium avium-induced resistance against insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice: role of Fas and Th1 cells.: Clin Exp Immunol. 1999 Feb;115(2):248-54. Unique Identifier : AIDSLINE MED/99132254; Martins TC; Aguas AP; Institute for Molecular and Cell Biology, Department of Anatomy; of the Institute Abel Salazar for the Biomedical Sciences,; University of Porto, Portugal.; NOD mice spontaneously develop autoimmune diabetes. One of the manipulations that prevent diabetes in NOD mice is infection with mycobacteria or immunization of mice with mycobacteria-containing adjuvant. Infection of NOD mice with Mycobacterium avium, done before the mice show overt diabetes, results in permanent pro
The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse.: Clin Exp Immunol. 1999 Feb;115(2):260-7. Unique Identifier : AIDSLINE MED/99132256; Ablamunits V; Elias D; Cohen IR; Department of Immunology, the Weizmann Institute of Science,; Rehovot, Israel.; The aim of the present study was to investigate the pathogenic properties of islet-infiltrating lymphocytes related to the severity of the autoimmune destruction of islet beta-cells in the NOD mouse. We analysed the development of insulin-dependent diabetes mellitus (IDDM) produced by adoptive transfer of islet lympho
Apoptosis of Th1-like cells in experimental tuberculosis (TB).: Clin Exp Immunol. 1999 Feb;115(2):324-8. Unique Identifier : AIDSLINE MED/99132265; Das G; Vohra H; Saha B; Agrewala JN; Mishra GC; National Centre for Cell Sciences, Ganeshkhind, Pune 411007,; India.; Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp
Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1.: Clin Exp Immunol. 1999 Feb;115(2):335-41. Unique Identifier : AIDSLINE MED/99132267; Lu Y; Xin KQ; Hamajima K; Tsuji T; Aoki I; Yang J; Sasaki S; Fukushima J; Yoshimura T; Toda S; Okada E; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, Japan.; CD8+ cell-secreted CC-chemokines, MIP-1alpha, and MIP-beta have recently been identified as factors which suppress HIV. In this study we co-inoculated MIP-1alpha expression plasmid with a DNA vaccine constructed from HIV-1 pCMV160IIIB and pcREV, and evaluated the effect of the adjuvant on HIV-specific immune responses
Maintenance hemodialysis in patients with HIV-associated nephropathy.: Unique Identifier : AIDSLINE MED/99092937; Dave MB; Shabih K; Blum S; OBJECTIVE: End-stage renal disease (ESRD) patients infected with human immunodeficiency virus (HIV) have poor survival on maintenance hemodialysis. Only a few studies have evaluated survival time on the basis of demographic and clinical factors. The clinical category of the HIV infection and total CD4 counts are commo
T-cell reactivity and its predictive role in immunosuppression after burns [see comments]: Crit Care Med. 1999 Jan;27(1):66-72. Unique Identifier : AIDSLINE MED/99131594; Zedler S; Bone RC; Baue AE; von Donnersmarck GH; Faist E; Department of Surgery, Klinikum Grosshadern,; Ludwig-Maximilians-University Munich, Germany.; OBJECTIVE: To obtain further insight into the constitutional, phenotype-dependent changes of T-helper-1 and T-helper-2 signature lymphokine synthesis after trauma. DESIGN: Prospective, descriptive study. SETTING: Intensive care unit of a burn center in a community hospital. PATIENTS: Ten patients 1, 3, 5, and 7 days a
A question of balance [editorial; comment]: Crit Care Med. 1999 Jan;27(1):7-8. Unique Identifier : AIDSLINE MED/99131572; Zimmerman JJ
Pericardial involvement in human immunodeficiency virus infection.: Chest. 1999 Feb;115(2):418-22. Unique Identifier : AIDSLINE MED/99149687; Silva-Cardoso J; Moura B; Martins L; Mota-Miranda A; Rocha-Goncalves F; Lecour H; Oporto Cardiovascular Research and Development Unit (JNICT; 51/94), Porto Medical School, Hospital de S. Joao, Portugal.; STUDY OBJECTIVES: Previous studies have showed that the pericardium is frequently involved in HIV infection. However, the characteristics and etiology of the pericardial abnormalities that have been found remained poorly defined. We analyzed the features of pericardial involvement in these patients and investigated th
Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis: molecular analysis of class II alleles by DNA amplification and oligonucleotide hybridization in Mexican patients.: Chest. 1999 Feb;115(2):428-33. Unique Identifier : AIDSLINE MED/99149689; Teran-Escandon D; Teran-Ortiz L; Camarena-Olvera A; Gonzalez-Avila G; Vaca-Marin MA; Granados J; Selman M; Instituto Nacional de Enfermedades Respiratorias, Mexico DF,; Mexico.; BACKGROUND: Pulmonary tuberculosis (PTB) develops by a complex combination of environmental factors with genetic susceptibility. In this context, an association between human leukocyte antigens (HLAs) and tuberculosis has been examined in several populations, but results have been controversial. DESIGN AND MEASUREMENT
Detection of pulmonary tuberculosis in patients with a normal chest radiograph.: Chest. 1999 Feb;115(2):445-52. Unique Identifier : AIDSLINE MED/99149692; Marciniuk DD; McNab BD; Martin WT; Hoeppner VH; Division of Tuberculosis Control, The Research Center for the; Elimination of Tuberculosis, Royal University Hospital,; University of Saskatchewan, Saskatoon, Canada.; OBJECTIVES: To describe the early symptoms of pulmonary tuberculosis (TB) when the chest radiograph (CXR) is normal. SETTING: Centralized, provincial TB control program. SUBJECTS: Twenty-five patients with culture-positive pulmonary TB and a normal CXR were identified from a review of 518 consecutive patients with cul
[Effects of green tea on growth inhibition and immune regulation of Lewis lung cancer in mice]: Chung Hua Yu Fang I Hsueh Tsa Chih. 1997 Nov;31(6):325-9. Unique Identifier : AIDSLINE MED/99080198; Zhu M; Gong Y; Ge G; Institute of Radiation Medicine, Academy of Military Medical; Sciences, Beijing.; C57/BL6J mice were inoculated with Lewis lung cancer cells as an experimental model to study the effects of green tea on cancer prevention, inhibition of tumor growth and immune regulation in mice with tumor. Results showed that weight of thymus in C57/BL6J mice and its index declined, proportion of positive CD4 subgr
Toxicokinetics of 2',3'-didehydro-3'-deoxythymidine, stavudine (D4T).: Drug Metab Dispos. 1999 Jan;27(1):1-12. Unique Identifier : AIDSLINE MED/99102127; Kaul S; Dandekar KA; Schilling BE; Barbhaiya RH; Metabolism and Pharmacokinetics and Drug Safety Evaluation,; Bristol-Myers Squibb Pharmaceutical Research Institute,; Princeton, New Jersey 08543-4000, USA.; The toxicokinetic profile of D4T was assessed by conducting in vivo and in vitro studies. In the various studies, the i.v. and oral doses ranged from 12.5 to 600 and 5 to 2000 mg/kg, respectively. D4T was rapidly absorbed with an absolute oral bioavailability ranging from 77 to 100% in various species. The steady-stat
First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme.: Drug Metab Dispos. 1999 Jan;27(1):113-21. Unique Identifier : AIDSLINE MED/99102143; Wen Y; Remmel RP; Zimmerman CL; Departments of Pharmaceutics and Medicinal Chemistry, University; of Minnesota, College of Pharmacy, Minneapolis, Minnesota 55455,; USA.; Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2 ,3 -didehydro-2 , 3 -dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained fr
Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys.: Drug Metab Dispos. 1999 Jan;27(1):41-5. Unique Identifier : AIDSLINE MED/99102131; Balani SK; Kauffman LR; deLuna FA; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; Efavirenz (EFV, Sustiva , Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Pharmacokinetics of EFV was studied in rats an
In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.: Drug Metab Dispos. 1999 Jan;27(1):86-91. Unique Identifier : AIDSLINE MED/99102138; Kumar GN; Jayanti V; Lee RD; Whittern DN; Uchic J; Thomas S; Johnson P; Grabowski B; Sham H; Betebenner D; Kempf DJ; Denissen JF; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064-3500, USA. gondi.kumar@abbott.com; HIV protease inhibitor ABT-378 (ABT-378) was metabolized very extensively and rapidly by liver microsomes from mouse, rat, dog, monkey, and humans. The rates of NADPH-dependent metabolism of ABT-378 ranged from 2.39 to 9.80 nmol.mg microsomal protein-1.min-1, with monkey liver microsomes exhibiting the highest rates o
[Focal mycobacterial lymphadenitis after starting highly active antiretroviral therapy]: Dtsch Med Wochenschr. 1999 Jan 22;124(3):45-8. Unique Identifier : AIDSLINE MED/99141958; Schwietert M; Battegay M; Medizinische Universitats-Poliklinik, Kantonsspital Basel.; HISTORY AND FINDINGS: A 30-year-old man with a known HIV infection for 7 years presented for treatment with antiretroviral drugs. He was known to have had herpes zoster, oral hairy leukoplakia and recurrent Candida stomatitis, but was otherwise without symptoms. INVESTIGATIONS: The CD4 lymphocyte count was 19 cells/mm
Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides.: Electrophoresis. 1998 Nov;19(16-17):2926-9. Unique Identifier : AIDSLINE MED/99085937; Vargas G; Revilla A; Havel J; Holy A; Masaryk University, Faculty of Science, Department of Analytical; Chemistry, Brno, Czech Republic.; The present work describes an electrophoretic method for the separation and determination of the new antivirals, 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,9-diaminopurine (PMEDAP) in model mixtures with some monoribonucleotide isomers (3 -AMP, 2 -CMP, 3 -CMP, 3 -GMP, 2 -GMP, 3 -UMP,
HPV and intraepithelial neoplasia recurrent lesions of the lower genital tract: assessment of the immune system.: Eur J Gynaecol Oncol. 1998;19(5):466-9. Unique Identifier : AIDSLINE MED/99079618; Stentella P; Frega A; Ciccarone M; Cipriano L; Tinari A; Tzantzoglou S; Pachi A; II Clinic of Obstetrics and Gynecology, University of Rome La; Sapienza, Italy.; OBJECTIVE: To evaluate the immune state in patients with genital relapse HPV and intraepithelial lesions of the lower genital tract. METHOD: Forty-three patients were selected. Twenty-one were affected by recurrent HPV infection either alone or combined with intraepithelial neoplasia treated by laser surgery, and 22 h
Risk of human immunodeficiency virus infection and genital ulcer disease among persons attending a sexually transmitted disease clinic in Italy.: Epidemiol Infect. 1998 Dec;121(3):623-30. Unique Identifier : AIDSLINE MED/99153783; Corona R; Caprilli F; Tosti ME; Gentili G; Giglio A; Prignano G; Pasquini P; Mele A; Laboratorio di Epidemiologia Clinica, Istituto Dermopatico; dell'Immacolata (IDI-IRCCS), Rome, Italy.; To assess the relative importance of ulcerative and non-ulcerative sexually transmitted disease in the transmission of HIV, a seroprevalence study was conducted on 2210 patients at the sexually transmitted diseases (STD) clinic of the S. Maria e S. Gallicano Hospital in Rome, between 1989 and 1994. Among male patients
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.: FEBS Lett. 1999 Jan 25;443(2):170-4. Unique Identifier : AIDSLINE MED/99142705; Wang L; Munch-Petersen B; Herrstrom Sjoberg A; Hellman U; Bergman T; Jornvall H; Eriksson S; Department of Veterinary Medical Chemistry, Swedish University of; Agricultural Sciences, Biomedical Center, Uppsala.; Based on amino acid sequence information from purified mitochondrial thymidine kinase (TK2), a cDNA of 1930 bp was cloned, containing an open reading frame encoding 232 amino acid residues starting with the N-terminal sequence determined from the native human protein preparation. Northern blot analysis with the cDNA c
HIV-1 gp160 decreases the K+ voltage-gated current from Jurkat E6.1 T cells by up-phosphorylation.: FEBS Lett. 1999 Jan 25;443(2):187-91. Unique Identifier : AIDSLINE MED/99142708; Dellis O; Bouteau F; Guenounou M; Rona JP; Laboratoire d'Electrophysiologie des Membranes, LPCMSP,; Universite Denis Diderot, Paris 7, France.; odellis@moka.ccr.jussieu.fr; HIV-1 gp120/gp160 is known to disturb the activity of p56lck, protein kinase C (PKC) and Ca2+ homeostasis in T lymphocytes. We found that gp160 decreases the Kv1.3 current of Jurkat E6.1 cells probably by increasing the PKC-dependent phosphorylation of Kv channel protein after 5 days. This decrease is dose-dependent.
Posttraumatic stress disorder in response to HIV infection.: Gen Hosp Psychiatry. 1998 Nov;20(6):345-52. Unique Identifier : AIDSLINE MED/99071810; Kelly B; Raphael B; Judd F; Perdices M; Kernutt G; Burnett P; Dunne M; Burrows G; Department of Psychiatry, University of Queensland, Brisbane,; Australia.; This study investigated the psychological impact of HIV infection through assessment of posttraumatic stress disorder in response to HIV infection. Sixty-one HIV-positive homosexual/bisexual men were assessed for posttraumatic stress disorder in response to HIV infection (PTSD-HIV) using a modified PTSD module of the
Treatment with risperidone of an acute psychotic episode in a patient with AIDS [letter]: Gen Hosp Psychiatry. 1998 Nov;20(6):384-5. Unique Identifier : AIDSLINE MED/99071818; Zilikis N; Nimatoudis I; Kiosses V; Ierodiakonou C
AIDS drug gets quick OK [news]: FDA Consum. 1999 Jan-Feb;33(1):2. Unique Identifier : AIDSLINE MED/99154407
[How to increase immune response in HIV-infected patients]: Fortschr Med. 1998 Nov 30;116(33):6. Unique Identifier : AIDSLINE MED/99106133; Gurtler L
Analysis of clonality of atypical cutaneous lymphoid infiltrates associated with drug therapy by PCR/DGGE.: Hum Pathol. 1999 Feb;30(2):130-6. Unique Identifier : AIDSLINE MED/99151897; Brady SP; Magro CM; Diaz-Cano SJ; Wolfe HJ; Department of Pathology, Tufts University School of Medicine,; Boston, MA, USA.; Atypical lymphocytic infiltrates that mimic cutaneous lymphoma (ie, pseudolymphoma) are often observed in skin biopsy specimens from patients with altered immune function. The latter may reflect systemic immune dysregulatory states such as collagen vascular disease or human immunodeficiency virus infection. Among the
Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes.: Immunol Lett. 1998 Nov;64(1):45-7. Unique Identifier : AIDSLINE MED/99081199; Pardridge WM; Yang J; Diagne A; Department of Medicine, UCLA School of Medicine, Los Angeles, CA; 90095-1682, USA. wpardrid@med1.medsch.ucla.edu; Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human
Elevation of serum IgE level and peripheral eosinophil count during T lymphocyte-directed gene therapy for ADA deficiency: implication of Tc2-like cells after gene transduction procedure.: Immunol Lett. 1998 Nov;64(1):49-53. Unique Identifier : AIDSLINE MED/99081200; Kawamura N; Ariga T; Ohtsu M; Yamada M; Tame A; Furuta H; Kobayashi I; Okano M; Yanagihara Y; Sakiyama Y; Department of Pediatrics, Hokkaido University School of Medicine,; Sapporo, Japan. nobu-ka@med.hokudai.ac.jp; We have successfully carried out T-cell-directed gene therapy for a boy with severe combined immunodeficiency due to adenosine deaminase deficiency (ADA SCID) and unexpectedly found an elevation of serum IgE level and peripheral eosinophil count during the course. More than 90% of transduced cells cultured for 7-11 da
Cytokine patterns in seropositive and seronegative patients with Echinococcus granulosus infection.: Immunol Lett. 1998 Nov;64(1):5-8. Unique Identifier : AIDSLINE MED/99081193; Rigano R; Profumo E; Ioppolo S; Notargiacomo S; Teggi A; Siracusano A; Laboratorio di Immunologia, Istituto Superiore di Sanita, Roma,; Italy.; To investigate the involvement of immunological variables, including the Th1/Th2 balance, in the mechanisms underlying seronegativity in cystic echinococcosis (CE), Th1 and Th2 cytokines were evaluated in ELISA determining IFN-gamma, IL-4, -5 and -10 production in peripheral blood mononuclear cell (PBMC) cultures from
Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci.: Immunogenetics. 1999 Mar;49(3):238-41. Unique Identifier : AIDSLINE MED/99115509; Scalzo AA; Brown MG; Chu DT; Heusel JW; Yokoyama WM; Forbes CA; Department of Microbiology, University of Western Australia,; Nedlands 6907, Western Australia, scals@cyllene.uwa.edu.au
New, emerging and re-emerging infectious diseases [editorial]: Indian J Public Health. 1997 Apr-Jun;41(2):35. Unique Identifier : AIDSLINE MED/99143519; Bansal RD; Bhasin SK
Relationship of national highway with injecting drug abuse and HIV in rural Manipur, India.: Indian J Public Health. 1997 Apr-Jun;41(2):49-51. Unique Identifier : AIDSLINE MED/99143522; Sarkar K; Panda S; Das N; Sarkar S; ICMR Unit for Research on AIDS in North-Eastern States of India,; Calcutta.; Earlier study reported that about 1% of general population or urban Manipur was injecting drug users (IDUs). A study was conducted to observe the IDU prevalence in rural Manipur and the role of national highway (NH) in determining the IDU prevalence if any. It was also aimed to study the HIV prevalence among IDUs of d
Koro associated with phobia for AIDS.: Int J Psychiatry Med. 1998;28(3):353-6. Unique Identifier : AIDSLINE MED/99060829; Chand SP; Sultan Qaboos University, Muscat, Sultanate of Oman.; Koro, in its complete, classic form has been described as a culture bound syndrome. It usually occurs in otherwise healthy individuals in the context of acute, severe anxiety. The incomplete form of Koro is said to occur as part of a recognizable primary psychiatric disorder. A case report is presented for the first t
Sexuality in the age of AIDS [letter]: Int J Psychoanal. 1998 Oct;79 ( Pt 5):1007-8. Unique Identifier : AIDSLINE MED/99089006; Blechner MJ
HIV knowledge, beliefs and sexual behavior of male heterosexual drug users and non-drug users attending an HIV testing clinic in Israel.: Isr J Psychiatry Relat Sci. 1998;35(4):307-17. Unique Identifier : AIDSLINE MED/99143534; Soskolne V; Maayan S; Department of Social Medicine, Hadassah University Hospital,; Jerusalem, Israel. varda@vms.huji.ac.il; The aim of the study was to compare HIV-related knowledge, beliefs in self-control and sexual behavior of non-drug using and drug using heterosexual men. All individuals attending an HIV testing site during a two-month period were asked to complete a questionnaire anonymously. Data for 49 drug users (DU), most of them
A world of research subjects.: Hastings Cent Rep. 1998 Nov-Dec;28(6):25. Unique Identifier : AIDSLINE MED/99085498; Emanuel EJ
AZT trials and tribulations.: Hastings Cent Rep. 1998 Nov-Dec;28(6):26-34. Unique Identifier : AIDSLINE MED/99085499; Crouch RA; Arras JD
Science in the service of healing.: Hastings Cent Rep. 1998 Nov-Dec;28(6):34-8. Unique Identifier : AIDSLINE MED/99085500; Grady C
Placebos and HIV. Lessons learned.: Hastings Cent Rep. 1998 Nov-Dec;28(6):43-8. Unique Identifier : AIDSLINE MED/99085502; Levine C
Gradual loss of IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS.: Hawaii Med J. 1998 Dec;57(12):733-4. Unique Identifier : AIDSLINE MED/99109265; Nerurkar VR; Chua PK; Shikuma CM; Dashwood WM; Milne CI; Woodward CL; Kobayashi G; Peterson JE; Yanagihara R; Retrovirology Research Laboratory, University of Hawaii at Manoa,; Honolulu, USA.; GB virus C/hepatitis G virus (GBV-C/HGV) is a positive-sense, single-stranded RNA virus belonging to the family Flaviviridae and is distantly related to hepatitis C virus (HCV). GBV-C/HGV can be transmitted by the parenteral and the sexual route. Among individuals infected with human immunodeficiency virus type 1 (HIV
The complexities of HIV testing mount [news]: J Ark Med Soc. 1999 Jan;95(8):334. Unique Identifier : AIDSLINE MED/99125604; Zuger A
CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.: J Biol Chem. 1999 Jan 29;274(5):3116-24. Unique Identifier : AIDSLINE MED/99115659; Slavik JM; Hutchcroft JE; Bierer BE; Department of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1 or Th2 differentiation. We have examined early signal transduction pathways recruited following T cell stimulation with either CD80 or CD86. Purified human peripheral T cells or Jurkat T cel
Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells.: J Biol Chem. 1999 Feb 5;274(6):3789-96. Unique Identifier : AIDSLINE GENBANK/AJ005355; Monnet C; Laune D; Laroche-Traineau J; Biard-Piechaczyk M; Briant L; Bes C; Pugniere M; Mani JC; Pau B; Cerutti M; Devauchelle G; Devaux C; Granier C; Chardes T; Faculte de Pharmacie, 15 Avenue Charles Flahault, 34060; Montpellier, France.; The monoclonal antibody (mAb) ST40, specific for the immunoglobulin complementarity-determining region (CDR) 3-like loop in domain 1 of the CD4 molecule, inhibits human immunodeficiency virus type 1 (HIV-1) promoter activity and viral transcription in HIV-infected cells. To design synthetic peptides from the ST40 para
3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection.: Unique Identifier : AIDSLINE MED/99121132; Kosa JL; Sweasy JB; We developed an in vivo selection to identify
The 1998 Lindberg Award. Comparison of glycerol preservation with cryopreservation methods on HIV-1 inactivation.: J Burn Care Rehabil. 1998 Nov-Dec;19(6):494-500. Unique Identifier : AIDSLINE MED/99064505; van Baare J; Cameron PU; Vardaxis N; Pagnon J; Reece J; Middelkoop E; Crowe SM; Euro Skin Bank, Beverwijk, The Netherlands. vanbaare@wxs.nl; Cryopreservation and glycerol preservation are 2 successful methods for long-term preservation of human cadaver skin. Preservation is subjected to strict criteria to minimize the risk of disease transmission. This investigation compares the effects of glycerol preservation and cryopreservation on the inactivation of H
Perforating folliculitis: report of a case in an HIV-infected man.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):300-2. Unique Identifier : AIDSLINE MED/99148720; Rubio FA; Herranz P; Robayna G; Pena JM; Contreras F; Casado M; Department of Dermatology, La Paz University Hospital, Madrid,; Spain.
Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):308-11. Unique Identifier : AIDSLINE MED/99148722; Sachsenberg-Studer EM; Dobrynski N; Sheldon J; Schulz TF; Pechere M; Nador RG; Spiliopoulos A; Nicod L; Saurat JH; Department of Dermatology, University Hospital, Geneva,; Switzerland.; Kaposi s sarcoma (KS) has been reported after solid organ transplantation mostly in recipients of renal, liver, heart, and bone allografts. We describe the first case of a patient with lung transplantation who developed KS of the skin, but also of the lung graft. The tumors were localized to places of previous trauma,
Severe paronychia due to zidovudine-induced neutropenia in a neonate.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):322-4. Unique Identifier : AIDSLINE MED/99148726; Russo F; Collantes C; Guerrero J; Department of Dermatology, Hospital Punta de Europa, Algeciras,; Spain. frussod@meditex.es; We describe the case of an HIV-perinatally exposed child who was treated with zidovudine prophylaxis for reduction of perinatal transmission. At 4 weeks of age, he developed severe paronychia of the great toes as a result of Candida albicans and Escherichia coli. At that time, laboratory tests showed anemia and neutro
Disseminated sporotrichosis with extensive cutaneous involvement in a patient with AIDS.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):350-5. Unique Identifier : AIDSLINE MED/99148734; Ware AJ; Cockerell CJ; Skiest DJ; Kussman HM; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas, USA.; Sporotrichosis most commonly presents as a localized, lymphocutaneous infection that follows trauma, such as an injury from a rose thorn. In patients infected with HIV, it may be widespread and disseminated. We describe a patient with AIDS who developed disseminated sporotrichosis, a rare opportunistic fungal infectio
Knowledge, attitudes and behaviours related to HIV and AIDS among chinese adolescents in hong kong.: J Adolesc. 1998 Dec;21(6):657-65. Unique Identifier : AIDSLINE MED/99138784; Davis C; Noel MB; Chan SF; Wing LS; University of New South Wales, Sydney, NSW 2052, Australia.; The purpose of this study was to assess HIV and AIDS knowledge and attitudes, source of HIV and AIDS information, and behaviours related to HIV and AIDS among Chinese adolescents in Hong Kong . Participants included 1259 (826 females
Asymptomatic HIV under the ADA: the invisible, yet legitimate disability.: J Contemp Health Law Policy. 1998 Fall;15(1):357-400. Unique Identifier : AIDSLINE MED/99143547; Davis CS
Development and standardization of methods to evaluate the antibody response to an HIV-1 candidate vaccine in secretions and sera of seronegative vaccine recipients.: J Immunol Methods. 1999 Jan 1;222(1-2):111-24. Unique Identifier : AIDSLINE MED/99144976; Raux M; Finkielsztejn L; Salmon-Ceron D; Bouchez H; Excler JL; Dulioust E; Grouin JM; Sicard D; Blondeau C; Pasteur Merieux Connaught, Clinical Sero-Immunology Laboratory,; Parc Industriel d'Incarville, Val de Reuil, France.; mraux@fr.pmc-vacc.com; Enzyme-linked immunosorbent assays (ELISA) were developed to test, in serum and mucosal samples, total IgG, total IgA, serum albumin, and anti-gp120 MN and anti-p24 LAI IgG and IgA levels. These ELISAs were optimized according to reagents and experimental conditions. Inter- and intra-assay coefficients of variation ra
CD4+ T cell enumeration in HIV infection with limited resources.: Unique Identifier : AIDSLINE MED/99144985; Sherman GG; Galpin JS; Patel JM; Mendelow BV; Glencross DK; The incidence of human immunodeficiency virus (HIV) infection continues to increase in South Africa . Limited resources are available for diagnosis and management of the disease and the
A mathematical analysis of the spread of HIV/AIDS in Japan.: IMA J Math Appl Med Biol. 1998 Dec;15(4):299-311. Unique Identifier : AIDSLINE MED/99136888; Kakehashi M; Institute of Health Sciences, Hiroshima University School of; Medicine, Japan.; The spread of HIV/AIDS in Japan was analysed using a mathematical model incorporating pair formations between adults and sexual contacts with commercial sex workers. The parameters involved in the model were carefully specified as realistically as possible to the actual situation in
[Advances in the treatment of severe refractory infections. 1) HIV infections]: Nippon Naika Gakkai Zasshi. 1998 Nov 10;87(11):2240-4. Unique Identifier : AIDSLINE MED/99119776; Oka S
Long term treatment with clarithromycin for cryptosporidiosis and emergence of drug resistant disseminated infection due to Mycobacterium avium: case report.: J Chemother. 1998 Dec;10(6):474-5. Unique Identifier : AIDSLINE MED/99091284; Matteelli A; Signorini L; Tebaldi A; Bombana E; Chatel G; Pinsi G; Clinic of Infectious and Tropical Diseases-University of Brescia,; Italy. carosi@master.cci.unibs.it; Macrolide resistance in disseminated Mycobacterium avium infection is of major concern in AIDS patients as these drugs represent the main component of combination therapy . Clarithromycin and azithromycin should not be used alone for the treatment and prophylaxis of the
Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression.: J Pathol. 1998 Oct;186(2):209-14. Unique Identifier : AIDSLINE MED/99123513; Hall AP; Irvine J; Blyth K; Cameron ER; Onions DE; Campbell ME; Department of Veterinary Pathology, Glasgow University Veterinary; School, U.K.; In order to investigate the role that the human T-lymphotropic virus type I (HTLV-I) tax oncogene plays in apoptosis and transformation in vivo, four lines of HTLV-I tax transgenic mice were generated under the regulatory control of the CD3-epsilon promoter-enhancer sequence. These mice develop a variety of phenotypes
New bicyclam-AZT conjugates: design, synthesis, anti-HIV evaluation, and their interaction with CXCR-4 coreceptor.: J Med Chem. 1999 Jan 28;42(2):229-41. Unique Identifier : AIDSLINE MED/99126512; Dessolin J; Galea P; Vlieghe P; Chermann JC; Kraus JL; Laboratoire de Chimie Biomoleculaire, Faculte des Sciences de; Luminy, case 901, Universite de la Mediterranee, 163 avenue de; Luminy, 13288 Marseille Cedex 9, France.; We report the synthesis of mono- and bis-tetraazamacrocycle- AZT conjugates. All new compounds were screened for their ability to inhibit HIV-1 replication in MT4 cell line and were compared to AZT alone. It appears that N-protected covalent prodrugs a
Three-dimensional quantitative structure-activity relationship study on cyclic urea derivatives as HIV-1 protease inhibitors: application of comparative molecular field analysis.: J Med Chem. 1999 Jan 28;42(2):249-59. Unique Identifier : AIDSLINE MED/99126514; Debnath AK; Biochemical Virology Laboratory, Lindsley F. Kimball Research; Institute of The New York Blood Center, 310 East 67th Street, New; York, New York 10021, USA. adebnath@server.nybc.org; Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been developed using comparative molecular field analysis (CoMFA) on a large data set (118 compounds) of diverse cyclic urea derivatives as protease inhibitors against the human imm
Psychosocial factors and high-risk sexual behavior: race differences among urban adolescents.: J Behav Med. 1998 Oct;21(5):451-67. Unique Identifier : AIDSLINE MED/99052851; Doljanac RF; Zimmerman MA; Department of Health Behavior and Health Education, School of; Public Health, University of Michigan, Ann Arbor 48109-2029, USA.; Adolescence is a period of sexual experimentation. We examined psychosocial predictors of high-risk sexual behavior and condom use. The sample included 824 ninth-graders, most of whom are African American. We conducted separate analyses for whites and African Americans. Predictors included alcohol and substance use, d
Cross-linking localization of a HIV-1 reverse transcriptase peptide involved in the binding of primer tRNALys3.: J Mol Biol. 1999 Jan 29;285(4):1339-46. Unique Identifier : AIDSLINE MED/99141382; Dufour E; Reinbolt J; Castroviejo M; Ehresmann B; Litvak S; Tarrago-Litvak L; Andreola ML; IFR 66 Pathologies Infectieuses, CNRS-Universite Victor Segalen; Bordeaux 2, EP-630, 1, rue Camille Saint Saens, Bordeaux Cedex,; 33077, France.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) initiates the synthesis of DNA from the 3 end of its specific primer, tRNALys3. The regions of tRNALys3 in close contact with RT are well known, while a precise knowledge of the RT regions interacting with tRNALys3 is not yet available. To address
Old and new issues in cervical cancer control [editorial; comment]: J Natl Cancer Inst. 1999 Feb 3;91(3):200-1. Unique Identifier : AIDSLINE MED/99154697; Critchlow CW; Kiviat NB
Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women [see comments]: J Natl Cancer Inst. 1999 Feb 3;91(3):226-36. Unique Identifier : AIDSLINE MED/99154704; Palefsky JM; Minkoff H; Kalish LA; Levine A; Sacks HS; Garcia P; Young M; Melnick S; Miotti P; Burk R; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA. joelp@labmed.ucsf.edu; BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women s I
Foamy viruses are unconventional retroviruses.: J Virol. 1999 Mar;73(3):1747-55. Unique Identifier : AIDSLINE MED/99138951; Linial ML; Division of Basic Sciences, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.
The hypervariable domain of the murine leukemia virus surface protein tolerates large insertions and deletions, enabling development of a retroviral particle display system.: J Virol. 1999 Mar;73(3):1802-8. Unique Identifier : AIDSLINE MED/99138957; Kayman SC; Park H; Saxon M; Pinter A; Laboratory of Retroviral Biology, Public Health Research; Institute, New York, New York 10016, USA. skayman@phr.nyu.edu; The surface proteins (SU) of murine type-C retroviruses have a central hypervariable domain devoid of cysteine and rich in proline. This 41-amino-acid region of Friend ecotropic murine leukemia virus SU was shown to be highly tolerant of insertions and deletions. Viruses in which either the N-terminal 30 amino acids o
Genetic analysis of a unique human immunodeficiency virus type 1 (HIV-1) with a primer binding site complementary to tRNAMet supports a role for U5-PBS stem-loop RNA structures in initiation of HIV-1 reverse transcription.: J Virol. 1999 Mar;73(3):1818-27. Unique Identifier : AIDSLINE MED/99138959; Kang SM; Morrow CD; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; Human immunodeficiency virus type 1 (HIV-1) exclusively uses tRNA3Lys to initiate reverse transcription. A novel HIV-1 mutant which stably utilizes tRNAMet rather than tRNA3Lys as a primer was previously identified [HXB2(Met-AC] (S.-M. Kang, Z. Zhang, and C. D. Morrow, J. Virol. 71:207-217, 1997). Comparison of RNA se
Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors.: Unique Identifier : AIDSLINE MED/99138960; Gasmi M; Glynn J; Jin MJ; Jolly DJ; Yee JK; Chen ST; Center for Gene Therapy, Chiron Technologies, San Diego,; California 92121, USA.; A number of human immunodeficiency type 1 (HIV-1)-based vectors have recently been shown to transduce nondividing cells in vivo as well as in vitro. However, if these vectors are to be considered for eventual clinical use, a major consideration is to reduce the probability of unintended generation of replication-compe
Acute effects of pathogenic simian-human immunodeficiency virus challenge on vaccine-induced cellular and humoral immune responses to Gag in rhesus macaques.: J Virol. 1999 Mar;73(3):1853-9. Unique Identifier : AIDSLINE MED/99138963; Steger KK; Waterman PM; Pauza CD; Department of Pathology and Laboratory Medicine, University of; Wisconsin-Madison, and Wisconsin Regional Primate Research; Center, Madison, Wisconsin 53706, USA.; Simian-human immunodeficiency virus (SHIV) infection in macaques provides a convenient model for testing vaccine efficacy and for understanding viral pathogenesis in AIDS. We immunized macaques with recombinant, Salmonella typhimurium (expressing Gag) or soluble Gag in adjuvant to generate T-cell-dependent lymphoproli
Multiple functions for the basic amino acids of the human T-cell leukemia virus type 1 matrix protein in viral transmission.: J Virol. 1999 Mar;73(3):1860-7. Unique Identifier : AIDSLINE MED/99138964; Le Blanc I; Rosenberg AR; Dokhelar MC; INSERM U332, Institut Cochin de Genetique Moleculaire, Paris,; France.; We studied the involvement of the human T-cell leukemia virus type 1 (HTLV-1) Gag matrix protein in the cell-to-cell transmission of the virus using missense mutations of the basic amino acids. These basic amino acids are clustered at the N terminus of the protein in other retroviruses and are responsible for targetin
Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.: J Virol. 1999 Mar;73(3):1868-77. Unique Identifier : AIDSLINE MED/99138965; Koseki S; Tanabe T; Tani K; Asano S; Shioda T; Nagai Y; Shimada T; Ohkawa J; Taira K; National Institute for Advanced Interdisciplinary Research, AIST,; MITI, Tsukuba Science City 305-8562, Institute of Medical; Science, University of Tokyo, Minato-ku, Tokyo 108-8539, Japan.; In order to determine the parameters that govern the activity of a ribozyme in vivo, we made a systematic analysis of chimeric tRNAVal ribozymes by measuring their cleavage activities in vitro as well as the steady-state levels of transcripts, the half-lives of transcribed tRNAVal ribozymes, and their activities in bo
Human immunodeficiency virus type 1 protease triggers a myristoyl switch that modulates membrane binding of Pr55(gag) and p17MA.: J Virol. 1999 Mar;73(3):1902-8. Unique Identifier : AIDSLINE MED/99138969; Hermida-Matsumoto L; Resh MD; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA.; The human immunodeficiency virus type 1 (HIV-1) Pr55(gag) gene product directs the assembly of virions at the inner surface of the cell plasma membrane. The specificity of plasma membrane binding by Pr55(gag) is conferred by a combination of an N-terminal myristoyl moiety and a basic residue-rich domain. Although the
Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.: J Virol. 1999 Mar;73(3):1909-17. Unique Identifier : AIDSLINE MED/99138970; Lin SF; Robinson DR; Miller G; Kung HJ; Department of Molecular Biology and Microbiology, School of; Medicine, Case Western Reserve University, Cleveland, Ohio 44016,; USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is a recently discovered human gamma herpesvirus strongly implicated in AIDS-related neoplasms. We report here the identification in the KSHV genome of a gene for a protein designated K-bZIP and belonging to the basic-leucine zipper (bZIP) family of transcription factors.
Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein.: J Virol. 1999 Mar;73(3):1931-40. Unique Identifier : AIDSLINE MED/99138972; Wilk T; Gowen B; Fuller SD; Structural Biology Programme, European Molecular Biology; Laboratory, 69117 Heidelberg, Germany.; Recently, it was shown that actin molecules are present in human immunodeficiency virus type 1 (HIV-1) particles. We have examined the basis for incorporation and the location of actin molecules within HIV-1 and murine retrovirus particles. Our results show that the retroviral Gag polyprotein is sufficient for actin u
Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.: J Virol. 1999 Mar;73(3):1956-63. Unique Identifier : AIDSLINE MED/99138975; Bartz SR; Emerman M; Divisions of Molecular Medicine and Basic Science, Fred; Hutchinson Cancer Research Center, Seattle, Washington, USA.; Apoptosis contributes to the loss of CD4 cells during human immunodeficiency virus type 1 (HIV-1) infection. Although the product of the env gene, gp160/gp120, is known to play a role in cell death mediated by HIV-1, the role of other HIV-1 genes in the process is unclear. We found that HIV-1 lacking the env gene (HIV
Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.: J Virol. 1999 Mar;73(3):1964-73. Unique Identifier : AIDSLINE MED/99138976; Mangasarian A; Piguet V; Wang JK; Chen YL; Trono D; Department of Genetics and Microbiology, University of Geneva,; Geneva, Switzerland.; The Nef protein of primate lentiviruses triggers the accelerated endocytosis of CD4 and of class I major histocompatibility complex (MHC-I), thereby down-modulating the cell surface expression of these receptors. Nef acts as a connector between the CD4 cytoplasmic tail and intracellular sorting pathways both in the Go
Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteins.: J Virol. 1999 Mar;73(3):1974-9. Unique Identifier : AIDSLINE MED/99138977; Gigler A; Dorsch S; Hemauer A; Williams C; Kim S; Young NS; Zolla-Pazner S; Wolf H; Gorny MK; Modrow S; Institut fur Medizinische Mikrobiologie und Hygiene,; Universitat Regensburg, 93053 Regensburg, Germany.; Infections caused by human parvovirus B19 are known to be controlled mainly by neutralizing antibodies. To analyze the immune reaction against parvovirus B19 proteins, four cell lines secreting human immunoglobulin G monoclonal antibodies (MAbs) were generated from two healthy donors and one human immunodeficiency vir
Conditions for copackaging rous sarcoma virus and murine leukemia virus Gag proteins during retroviral budding.: J Virol. 1999 Mar;73(3):2045-51. Unique Identifier : AIDSLINE MED/99138985; Bennett RP; Wills JW; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.; Rous sarcoma virus (RSV) and murine leukemia virus (MLV) are examples of distantly related retroviruses that normally do not encounter one another in nature. Their Gag proteins direct particle assembly at the plasma membrane but possess very little sequence similarity. As expected, coexpression of these two Gag protei
High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.: J Virol. 1999 Mar;73(3):2064-73. Unique Identifier : AIDSLINE MED/99138988; Chene L; Nugeyre MT; Barre-Sinoussi F; Israel N; Unite de Biologie des Retrovirus, Institut Pasteur, 75724 Paris; Cedex 15, France.; We have previously demonstrated that interaction of infected thymocytes with autologous thymic epithelial cells (TEC) is a prerequisite for a high level of human immunodeficiency virus type 1 (HIV-1) replication in thymocytes (M. Rothe, L. Chene, M. Nugeyre, F. Barre-Sinoussi, and N. I
The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo.: J Virol. 1999 Mar;73(3):2099-108. Unique Identifier : AIDSLINE MED/99138992; Weekes MP; Wills MR; Mynard K; Carmichael AJ; Sissons JG; Department of Medicine, University of Cambridge Clinical School,; Cambridge CB2 2QQ, United Kingdom.; Human cytomegalovirus (HCMV)-specific CD8(+) cytotoxic T lymphocytes (CTL) appear to play an important role in the control of virus replication and in protection against HCMV-related disease. We have previously reported high frequencies of memory CTL precursors (CTLp) specific to t
Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.: J Virol. 1999 Mar;73(3):2126-35. Unique Identifier : AIDSLINE MED/99138995; Wu X; Liu H; Xiao H; Conway JA; Hehl E; Kalpana GV; Prasad V; Kappes JC; Department of Medicine, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN) is essential for integration of the viral DNA into host cell chromosomes. Since IN is expressed and assembled into virions as part of the 160-kDa Gag-Pol precursor polyprotein and catalyzes integration of the provirus in infected cells as a mature
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression.: J Virol. 1999 Mar;73(3):2232-42. Unique Identifier : AIDSLINE MED/99139006; Sun R; Lin SF; Staskus K; Gradoville L; Grogan E; Haase A; Miller G; Department of Molecular Biophysics and Biochemistry, Yale; University School of Medicine, New Haven, Connecticut 06520, USA.; Herpesvirus gene expression can be classified into four distinct kinetic stages: latent, immediate early, early, and late. Here we characterize the kinetic class of a group of 16 Kaposi s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 genes in a cultured primary effusion cell line and examine the expression
In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain.: J Virol. 1999 Mar;73(3):2270-9. Unique Identifier : AIDSLINE MED/99139010; Campbell S; Rein A; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702, USA.; campbells@mail.ncifcrf.gov; Human immunodeficiency virus type 1 (HIV-1) normally assembles into particles of 100 to 120 nm in diameter by budding through the plasma membrane of the cell. The Gag polyprotein is the only viral protein that is required for the formation of these particles. We have used an in vitro assembly system to examine the ass
Dissecting the immune response to moloney murine sarcoma/leukemia virus-induced tumors by means of a DNA vaccination approach.: J Virol. 1999 Mar;73(3):2280-7. Unique Identifier : AIDSLINE MED/99139011; Milan G; Zambon A; Cavinato M; Zanovello P; Rosato A; Collavo D; Immunology Section, Department of Oncology and Surgical Sciences,; University of Padova, 35128 Padua, Italy.; The intramuscular inoculation of Moloney murine sarcoma/leukemia (M-MSV/M-MuLV) retroviral complex gives rise to sarcomas that undergo spontaneous regression due to the induction of a strong immune reaction mediated primarily by cytotoxic T lymphocytes (CTL). We used a DNA-based vaccination approach to dissect the CTL
Identification of retroviral late domains as determinants of particle size.: J Virol. 1999 Mar;73(3):2309-20. Unique Identifier : AIDSLINE MED/99139014; Garnier L; Parent LJ; Rovinski B; Cao SX; Wills JW; Departments of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.; Retroviral Gag proteins, in the absence of any other viral products, induce budding and release of spherical, virus-like particles from the plasma membrane. Gag-produced particles, like those of authentic retrovirions, are not uniform in diameter but nevertheless fall within a fairly narrow distribution of sizes. For
Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage.: J Virol. 1999 Mar;73(3):2343-9. Unique Identifier : AIDSLINE MED/99139017; Morner A; Bjorndal A; Albert J; Kewalramani VN; Littman DR; Inoue R; Thorstensson R; Fenyo EM; Bjorling E; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Swedish Institute for Infectious Disease Control, Stockholm,; Sweden. andreas.morner@mtc.ki.se; Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Since CXCR4 usage determines the biological phenotype for HIV-1 isolates an
V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.: J Virol. 1999 Mar;73(3):2350-8. Unique Identifier : AIDSLINE MED/99139018; Chan SY; Speck RF; Power C; Gaffen SL; Chesebro B; Goldsmith MA; Gladstone Institute of Virology and Immunology, San Francisco,; California, USA.; Binding of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 to both CD4 and one of several chemokine receptors (coreceptors) permits entry of virus into target cells. Infection of tissues may establish latent viral reservoirs as well as cause direct pathologic effects that manifest as clinic
CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function.: J Virol. 1999 Mar;73(3):2450-9. Unique Identifier : AIDSLINE MED/99139030; Mariani R; Wong S; Mulder LC; Wilkinson DA; Reinhart AL; LaRosa G; Nibbs R; O'Brien TR; Michael NL; Connor RI; Macdonald M; Busch M; Koup RA; Landau NR; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change
A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.: J Virol. 1999 Mar;73(3):2469-80. Unique Identifier : AIDSLINE MED/99139032; Salzwedel K; West JT; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; Mutations were introduced into the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane envelope glycoprotein, gp41, within a region immediately adjacent to the membrane-spanning domain. This region, which is predicted to form an alpha-helix, contains highly conserved hydrophobic residues and is
Productive infection of human peripheral blood mononuclear cells by feline immunodeficiency virus: implications for vector development.: J Virol. 1999 Mar;73(3):2491-8. Unique Identifier : AIDSLINE MED/99139034; Johnston J; Power C; Department of Clinical Neurosciences and Department of; Microbiology and Infectious Diseases, University of Calgary,; Calgary, Alberta, Canada T2N 4N1.; Feline immunodeficiency virus (FIV) is a lentivirus causing immune suppression and neurological disease in cats. Like primate lentiviruses, FIV utilizes the chemokine receptor CXCR4 for infection. In addition, FIV gene expression has been demonstrated in immortalized human cell lines. To investigate the extent and mec
Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.: J Virol. 1999 Mar;73(3):2499-508. Unique Identifier : AIDSLINE MED/99139035; Ulich C; Dunne A; Parry E; Hooker CW; Gaynor RB; Harrich D; Division of Hematology and Oncology, Departments of Internal; Medicine and Microbiology, University of Texas Southwestern; Medical Center, Dallas, Texas 75235-8594, USA.; Tat expression is required for efficient human immunodeficiency virus type 1 (HIV-1) reverse transcription. In the present study, we generated a series of 293 cell lines that contained a provirus with a tat gene deletion (Deltatat). Cell lines that contained Deltatat and stably transfected vectors containing either wi
[Effective splenectomy in a patient with HIV-associated thrombocytopenia]: Rinsho Ketsueki. 1998 Nov;39(11):1137-9. Unique Identifier : AIDSLINE MED/99083660; Kato Y; Nakamura K; Haraguchi K; Ajima A; Fujita H; Tomiyama J; Kudo H; Onozawa Y; Ohnishi K; Umekita N; Department of Internal Medicine, Tokyo Metropolitan Bokuto; General Hospital.; A 31-year-old man presented with a 3-month history of petechial hemorrhages. Physical examination revealed no splenomegaly. The patient s platelet count was 1.0 x 10(9)/l and bone marrow aspiration showed an elevated number of megakaryocytes. A diagnosis of HIV-associated thrombocytopenia was made on the basis of HIV
[Laboratory diagnosis of viral infections. 9. Viral infections related to blood transfusion and organ transplantation]: Rinsho Byori. 1998 Nov;Suppl 108:111-5. Unique Identifier : AIDSLINE MED/99119807; Miyamoto A; Tsutsumi Y; Sato H; Maeda Y
[Chemotherapy and vaccines used for the management of viral infections]: Rinsho Byori. 1998 Nov;Suppl 108:36-41. Unique Identifier : AIDSLINE MED/99119798; Yamane S
[Laboratory diagnosis of viral infections. 7. Opportunistic infection by herpesviruses (human cytomegalovirus, Epstein-Barr virus, and human herpesvirus 8)]: Rinsho Byori. 1998 Nov;Suppl 108:98-104. Unique Identifier : AIDSLINE MED/99119805; Okuno T
Gray-white, spherical deposition on retinal vessel associated with acute retinal necrosis and diabetic retinopathy in HTLV-I carriers.: Jpn J Ophthalmol. 1998 Nov-Dec;42(6):490-4. Unique Identifier : AIDSLINE MED/99101832; Nakao K; Ohba N; Uemura A; Okubo A; Sameshima M; Hayami K; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.; Tiny, gray-white, spherical deposits were found on the retinal vessels and vitreoretinal interface of the fovea in a 55-year-old woman with acute retinal necrosis due to varicella-zoster virus, and in a 47-year-old man with preproliferative diabetic retinopathy. Both patients developed massive vitreous opacities due t
Multi-clonal expansion of unique human T-lymphotropic virus type-I-infected T cells with high growth potential in response to interleukin-2 in prodromal phase of adult T cell leukemia.: Leukemia. 1999 Feb;13(2):215-21. Unique Identifier : AIDSLINE MED/99148762; Hata T; Fujimoto T; Tsushima H; Murata K; Tsukasaki K; Atogami S; Sohda H; Honda S; Mine M; Yamada Y; Ikeda S; Kamihira S; Tomonaga M; Department of Hematology, Atomic Bomb Disease Institute, Nagasaki; University School of Medicine, Japan.; We established a simple IL-2-dependent colony-forming assay for T cells infected with human T-lymphotropic virus type-I (HTLV-I). IL-2-dependent cell lines were subsequently established by expanding individual colonies in liquid cultures. Lymphocyte-rich fractions were prepared from 31 HTLV-I carriers, 12 patients wit
In vitro infection of CD4+ T lymphocytes with HTLV-I generates immortalized cell lines coexpressing lymphoid and myeloid cell markers.: Leukemia. 1999 Feb;13(2):222-9. Unique Identifier : AIDSLINE MED/99148763; Tricarico M; Macchi B; D'Atri S; Morrone S; Bonmassar E; Fuggetta MP; Graziani G; Institute of Experimental Medicine, National Research Council,; Area di Ricerca di Tor Vergata, Rome, Italy.; The human T cell leukemia/lymphoma virus (HTLV-I) is the etiologic agent of adult T cell leukemia (ATL). CD4+ lymphocytes are the preferential targets of infection, even though other cell types can be infected in vitro by the virus. Although ATL cells show CD3 and CD4 surface markers, some ATL-derived cell lines were
Development of an Epstein-Barr virus type 2 (EBV-2)-associated hepatic B cell non-Hodgkin's lymphoma in an HIV-1-infected patient following a change in the EBV dominant type.: Leukemia. 1999 Feb;13(2):298-301. Unique Identifier : AIDSLINE MED/99148773; Buisson M; Morand P; Peoc'h M; Bouchard O; Bourgeat MJ; Seigneurin JM; Laboratoire de Virologie Medicale Moleculaire, RHAP-CNRS,; Faculte de Medecine, Grenoble, France.; From the longitudinal study of a cohort of HIV-positive patients, we report the case of a patient who initially harbored the Epstein-Barr virus (EBV) type 1 and subsequently developed an EBV-2-associated non-Hodgkin s B lymphoma a few years after an EBV-2 reactivation, or an exogenous reactivation, in the blood. At th
[Pneumocystis carinii is still a dangerous opportunist. The infection is continuously a threat to immunocompromised patients]: Lakartidningen. 1999 Jan 27;96(4):328-31. Unique Identifier : AIDSLINE MED/99148960; Olsson M; Elvin K; Linder E; Lofdahl S; Wahlgren M; Parasitologiska enheten, Smittskyddsinstitutet, Stockholm.; Despite recent decrease in the incidence of Pneumocystis carinii pneumonia (PCP) among patients infected with HIV (human immunodeficiency virus), PCP remains a threat to other categories of immunocompromised patients. The article provides an outline of recent, mainly molecular genetic, findings in P. carinii research,
India has the largest number of people infected with HIV [news]: Lancet. 1999 Jan 2;353(9146):48. Unique Identifier : AIDSLINE MED/99146568; Kumar S
US drug project abandons needle exchange [news]: Lancet. 1999 Jan 2;353(9146):49. Unique Identifier : AIDSLINE MED/99146569; Morris K
HIV-1 replication in patients with undetectable plasma virus receiving HAART. Highly active antiretroviral therapy [letter]: Lancet. 1999 Jan 9;353(9147):119-20. Unique Identifier : AIDSLINE MED/99146508; Natarajan V; Bosche M; Metcalf JA; Ward DJ; Lane HC; Kovacs JA
Further clues emerge for strategies to attack HIV [news]: Lancet. 1999 Jan 9;353(9147):125. Unique Identifier : AIDSLINE MED/99146514; McCarthy M
No clinical trials sanctioned for South Africa's controversial HIV drug [news]: Lancet. 1999 Jan 9;353(9147):125. Unique Identifier : AIDSLINE MED/99146515; Baleta A
Widespread horror over killing of AIDS activist in South Africa [news]: Lancet. 1999 Jan 9;353(9147):130. Unique Identifier : AIDSLINE MED/99146518; Baleta A
Access to treatment for HIV in developing countries [letter]: Lancet. 1999 Jan 9;353(9147):153. Unique Identifier : AIDSLINE MED/99146535; Kroes AC; Leendertse D; Spaan WJ
Rapid serodiagnosis of Mycobacterium avium-intracellulare complex infection by ELISA with cord factor (trehalose 6, 6'-dimycolate), and serotyping using the glycopeptidolipid antigen.: Microbiol Immunol. 1998;42(10):689-96. Unique Identifier : AIDSLINE MED/99074175; Enomoto K; Oka S; Fujiwara N; Okamoto T; Okuda Y; Maekura R; Kuroki T; Yano I; Department of Bacteriology, Osaka City University Medical School,; Osaka, Japan.; Mycobacterium avium-intracellulare complex (MAC) is one of the most important opportunistic pathogens, particularly in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine whether an enzyme-linked immunosorbent assay (ELISA) using trehalose 6,6 -dimycolate (TDM) as an antigen
Genomic analysis of the viral population in genital secretions early after infection of simian immunodeficiency viruses in macaque monkeys.: Microbiol Immunol. 1998;42(10):715-22. Unique Identifier : AIDSLINE MED/99074178; Enose Y; Ibuki K; Shimada T; Ui M; Hayami M; Institute for Virus Research, Kyoto University, Kyoto, Japan.; To clarify the change in the viral population during passage from the vaginal cavity to blood circulation and vice versa, we examined the viral clones detected in cells in vaginal washes (VWCs) early after inoculation and after systemic infection with polyclonal SIV. In two intravaginally inoculated monkeys, the viral
The inter-relation of maternal immune competence, HIV-1 viral load, and nutritional status in preventing vertical transmission: an alternative to chemoprophylaxis?: Med Hypotheses. 1998 Nov;51(5):389-97. Unique Identifier : AIDSLINE MED/99063213; Moran PJ; Welles SL; Williams MA; Department of Epidemiology, University of Washington, School of; Public Health and Community Medicine, Seattle 98195, USA.; As the human immunodeficiency virus (HIV) global pandemic moves towards the end of its second decade, women of reproductive age throughout the world have been shown to be increasingly at risk for acquiring HIV-1 infection. Recently, the focus for preventive measures has expanded to include preventing the perinatal tra
Itraconazole and HIV protease inhibitors: an important interaction [letter]: Med J Aust. 1999 Jan 4;170(1):46-7. Unique Identifier : AIDSLINE MED/99150739; MacKenzie-Wood AR; Whitfeld MJ; Ray JE
[A functional model of the central epitope of the V3 loop of HIV-1 gp120 when complexed with antibodies]: Mol Biol (Mosk). 1998 Nov-Dec;32(6):1062-74. Unique Identifier : AIDSLINE MED/99128748; Shchelkanov MIu; Iaroslavtseva NG; Emel'ianov AV; Sakhuriia IB; Abelian AV; Verevochkin SV; Kozlov AP; Karamov EV
[Tandem bifunctional derivatives of short oligonucleotides--inhibitors of replication of the human immunodeficiency virus in cell culture]: Mol Biol (Mosk). 1998 Nov-Dec;32(6):1085-90. Unique Identifier : AIDSLINE MED/99128749; Pliasunova OA; Mamaeva OA; Pyshnyi DV; Pyshnaia IA; Ivanova EM; Vorob'ev PE; Zarytova VF; Pokrovskii AG
[Some aspects of the pathogenesis of HIV infection]: Mol Biol (Mosk). 1998 Nov-Dec;32(6):933-9. Unique Identifier : AIDSLINE MED/99128728; Eremin VF; Votiakov VI; Titov LP
Dilated cardiomyopathy in HIV-infected patients [letter]: N Engl J Med. 1999 Mar 4;340(9):732; discussion 733-5. Unique Identifier : AIDSLINE MED/99150075; Chariot P; Perchet H; Monnet I
Dilated cardiomyopathy in HIV-infected patients [letter]: N Engl J Med. 1999 Mar 4;340(9):732-3; discussion 733-4. Unique Identifier : AIDSLINE MED/99150076; Malnick S; Goland S
Dilated cardiomyopathy in HIV-infected patients [letter]: N Engl J Med. 1999 Mar 4;340(9):733-4. Unique Identifier : AIDSLINE MED/99150077; Flotats A; Domingo P; Carrio I
[Accidental exposure to blood and the risk of transmission of virus infections for various occupational groups in Amsterdam, 1986-1996]: Ned Tijdschr Geneeskd. 1998 Oct 17;142(42):2312-4. Unique Identifier : AIDSLINE MED/99082047; Berger CM; Leentvaar-Kuijpers A; Van Doornum GJ; Coutinho RA; GG&GD, divisie Volksgezondheid en Milieu, Nieuwe Achtergracht,; Amsterdam.; Since 1986 the number of parenteral exposures to potentially infectious blood reported to the Amsterdam Public Health Service increases every year. The number of needlestick accidents increased significantly from 64 in 1986 to 166 in 1996 whereas the number of other exposures decreased from 59 to 44 in these years. Th
Chemokines, renal disease, and HIV infection.: Nephron. 1999 Jan;81(1):5-16. Unique Identifier : AIDSLINE MED/99102657; Wenzel UO; Stahl RA; Department of Medicine, Division of Nephrology, University of; Hamburg, Germany.wenzel@uke.uni-hamburg.de; Renal disease is characterized by the influx of leukocytes into the injured tissue. Before leukocytes can exert their effects on renal damage or repair, they have to reach the site of injury. To recruit specific populations of leukocytes during inflammation is the role of a family of cytokines called chemokines. The c
HTLV-II risk factors in Native Americans in Florida.: Neuroepidemiology. 1999;18(1):37-47. Unique Identifier : AIDSLINE MED/99051393; Lowis GW; Sheremata WA; Wickman PR; Dube S; Dube K; Poiesz BJ; Department of Epidemiology and Public Health, School of Medicine,; University of Miami, Fla. 33136, USA.; Earlier virologic studies established that human T-cell lymphotropic virus type II (HTLV-II) is the predominant retrovirus type found among Seminole Indians in southern Florida. We studied 46 members of the Seminole tribe living on 3 reservations to determine the risk factors for HTLV-II and to investigate disease ass
Neuronal death induced by SIN-1 in the presence of superoxide dismutase: protection by cyclic GMP.: Neuropharmacology. 1998 Aug;37(8):1071-9. Unique Identifier : AIDSLINE MED/99049382; Moro MA; Fernandez-Tome P; Leza JC; Lorenzo P; Lizasoain I; Departamento de Farmacologia, Facultad de Medicina, Universidad; Complutense de Madrid, Spain. nlfucm@eucmax.sim.ucm.es; The nitrovasodilator 3-morpholinosydnonimine (SIN-1) slowly decomposes to release both nitric oxide (NO) and superoxide (O2-) and thereby produces peroxynitrite (ONOO-), a powerful oxidant which has been proposed to mediate the toxic actions caused by NO. Indeed, ONOO has been shown to cause neuronal death and it has
Evaluation of nursing practice: process and critique.: Nurs Sci Q. 1998 Summer;11(2):64-8. Unique Identifier : AIDSLINE MED/99155485; Braunstein MS; Madonna University, Livonia, MI, USA.; This article describes the difficulties in conducting clinical trials to evaluate nursing practice models. Suggestions are offered for strengthening the process. A clinical trial of a nursing practice model based on a synthesis of Aristotelian theory with Rogers science is described. The rationale for decisions regar
Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation.: Oncogene. 1999 Feb 11;18(6):1341-9. Unique Identifier : AIDSLINE MED/99145414; Harhaj EW; Good L; Xiao G; Sun SC; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033, USA.; Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell malignancy. A key step in HTLV-I-induced leukemigenesis is induction of abnormal T-cell growth and survival. Unlike antigen-stimulated T cells, which cease proliferation after a finite number of
Mefloquine-induced grand mal seizure in tubercular meningitis.: Panminerva Med. 1998 Dec;40(4):345-6. Unique Identifier : AIDSLINE MED/99139238; Bregani ER; Tien TV; Figini G; Division of Emergency Medicine, Ospedale Maggiore IRCCS, Milan,; Italy.; Mefloquine represents a promising antimalarial drug against Plasmodium falciparum. It has been related to an increase in seizure frequency in epileptic patients and should not be administered to patients with a history of convulsions, epilepsy in first degree relatives, or serious psychiatric disorders. We report a ca
[What motivates people to get tested for HIV antibodies?]: Pol Arch Med Wewn. 1998 May;99(5):403-6. Unique Identifier : AIDSLINE MED/99033678; Wiercinska-Drapalo A; Rogowska-Szadkowska D; Prokopowicz D; Klinika Obserwacyjno-Zakazna Akademii Medycznej w Bialymstoku.; The aim of the study was to evaluate reasons for anti-HIV testing among persons admitted to Outpatient Counseling Unit. Serum examination for antibodies against HIV were performed in 389 persons during 8 years of the Unit activity. The most frequently it was analysed in intravenous drug users. However there are still
Model for using hip-hop music for small group HIV/AIDS prevention counseling with African American adolescents and young adults.: Patient Educ Couns. 1998 Oct;35(2):127-37. Unique Identifier : AIDSLINE MED/99150617; Stephens T; Braithwaite RL; Taylor SE; Department of Behavioral Sciences and Health Education, Rollins; School of Public Health, Emory University, Atlanta, GA 30322,; USA. tstephe@sph.emory.edu; Currently little attention has been directed, with the exception of peer education efforts, to constructively develop new and innovative ways to promote HIV/AIDS primary prevention among African American (AA) adolescents and young adults. With this in mind, the aim of this conceptual effort is to present a HIV/AIDS pr
Mucocutaneous manifestations in children with HIV infection and AIDS.: Pediatr Dermatol. 1998 Nov-Dec;15(6):429-34. Unique Identifier : AIDSLINE MED/99091191; El Hachem M; Bernardi S; Pianosi G; Krzysztofiak A; Livadiotti S; Gattinara GC; Department of Dermatology, Bambino Gesu Children's Hospital and; Health Research Institute-Rome, Italy.; Mucocutaneous diseases are more frequent in HIV/AIDS-infected children than in the normal population. We analyze mucocutaneous disorders with atypical presentations in a large population of HIV-infected children, with or without full-blown AIDS, compared to a population of HIV seroreverted children. The majority of th
Stepwise transformation of a cholera toxin and a p24 (HIV-1) epitope into D-peptide analogs.: Protein Eng. 1998 Oct;11(10):941-8. Unique Identifier : AIDSLINE MED/99077031; Kramer A; Stigler RD; Knaute T; Hoffmann B; Schneider-Mergener J; Institut fur Medizinische Immunologie, Universitatsklinikum; Charite, Humboldt-Universitat zu Berlin, Germany.; We have transformed two peptide epitopes into D-peptide analogs: VPGSQHIDS derived from cholera toxin recognized by the antibody TE33, and GATPQDLNTML from the HIV-1 capsid protein p24 recognized by the antibody CB4-1. The transformation process was performed by stepwise substitution of each single epitope position by
A two-step, two-signal model for the primary activation of precursor helper T cells.: Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):185-90. Unique Identifier : AIDSLINE MED/99093511; Bretscher PA; Department of Microbiology and Immunology, University of; Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5; Canada. bretschr@duke.usak.ca; I present here a new model for the primary activation of precursor helper T cells. Observations demonstrate that the immune system learns not to respond to extrathymic, organ-specific self-antigens because of their early appearance in development. The immune system thus discriminates between peripheral self-antigens a
Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency.: Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):232-7. Unique Identifier : AIDSLINE MED/99093519; Bunting KD; Flynn KJ; Riberdy JM; Doherty PC; Sorrentino BP; Division of Experimental Hematology, St. Jude Children's Research; Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.; Human severe combined immunodeficiency (SCID) can be caused by defects in Janus kinase 3 (JAK3)-dependent cytokine signaling pathways. As a result, patients are at high risk of life-threatening infection. A JAK3 -/- SCID mouse model for the human disease has been used to test whether transplant with retrovirally trans
Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis.: Unique Identifier : AIDSLINE MED/99093496; Kaneshiro ES; Amit Z; Swonger MM; Kreishman GP; Brooks EE; Kreishman M; Jayasimhulu K; Parish EJ; Sun H; Kizito SA; Beach DH; Pneumocystis carinii pneumonia (PcP) remains among the most prevalent opportunistic infections among AIDS patients. Currently, drugs used clinically for deep mycosis act by binding ergosterol or disrupting its biosynthesis. Although classified as a fungus, P. carinii lacks ergosterol. Instead, the pathogen synthesizes
Stressful events, pessimism, natural killer cell cytotoxicity, and cytotoxic/suppressor T cells in HIV+ black women at risk for cervical cancer.: Psychosom Med. 1998 Nov-Dec;60(6):714-22. Unique Identifier : AIDSLINE MED/99061487; Byrnes DM; Antoni MH; Goodkin K; Efantis-Potter J; Asthana D; Simon T; Munajj J; Ironson G; Fletcher MA; Department of Psychology, University of Miami, Coral Gables,; Florida 33124, USA.; OBJECTIVE: This study examines whether stressful negative life events and pessimism were associated with lower natural killer cell cytotoxicity (NKCC) and T cytotoxic/suppressor cell (CD8+CD3+) percentage in black women co-infected with human immunodeficiency virus Type 1 (HIV-1) and human papillomavirus (HPV), a vira
Fatigue in HIV illness: relationship to depression, physical limitations, and disability.: Psychosom Med. 1998 Nov-Dec;60(6):759-64. Unique Identifier : AIDSLINE MED/99061494; Ferrando S; Evans S; Goggin K; Sewell M; Fishman B; Rabkin J; Department of Psychiatry, Cornell University Medical College, New; York, New York, USA. sjferran@mail.med.cornell.edu; OBJECTIVE: This study was conducted to investigate the prevalence of clinical fatigue reported by gay/bisexual men at all HIV illness stages, and whether fatigue, while associated with depression, independently contributes to limitations in physical function and disability. METHOD: HIV- men, HIV+ men with CD4 counts >
[Diagnostic imaging in AIDS-related pulmonary Kaposi's sarcoma]: Radiol Med (Torino). 1998 Oct;96(4):313-7. Unique Identifier : AIDSLINE MED/99138156; Busi Rizzi E; Schinina V; Mazzuoli G; Armignacco O; Cecconi L; Servizio di Radiologia, Azienda Ospedaliera IRCCS L. Spallanzani,; Roma.; INTRODUCTION: Kaposi s sarcoma is an uncommon multifocal angiogenic lesion but the most frequent tumor (15%) in HIV+ patients: it is found in homosexual HIV+ men in 95% of cases and appears as cutaneous-mucous lesions in most patients; the respiratory system is involved in 20% of cases. We investigated the yield of co
[AIDS-related pulmonary Kaposi's sarcoma: role of high-resolution computerized tomography]: Radiol Med (Torino). 1998 Oct;96(4):318-24. Unique Identifier : AIDSLINE MED/99138157; Pompili GG; Dellafiore L; Soldi S; Alineri S; Bonetto S; Santambrogio S; Cornalba G; Servizio di Radiologia Diagnostica e Interventistica, Azienda; Ospedaliera Luigi Sacco, Milano.; INTRODUCTION: HIV-related Kaposi sarcoma (KS) is characterized by lesion multifocality, stronger progression and recurrent involvement of some internal organs. Pulmonary lesions are found in 18-47% of cases and not necessarily associated with skin involvement. Lung infections are potentially life-threatening and their
[Invasive aspergillosis in AIDS: findings with high-resolution computerized tomography]: Radiol Med (Torino). 1998 Oct;96(4):325-30. Unique Identifier : AIDSLINE MED/99138158; Pompili GG; Alineri S; Arborio G; Bianco R; Cornalba G; Servizio di Radiologia Diagnostica e Interventistica, Azienda; Ospedaliera L. Sacco, Milano.; PURPOSE: To review the early CT findings of invasive aspergillosis in AIDS patients who are at high risk for developing this infection. Early recognition of invasive fungal disease is imperative in these patients, and longer survival can be achieved with early CT detection and prompt institution of high-dose antifunga
[European surveillance of infectious diseases: the case of AIDS and tuberculosis]: Rev Epidemiol Sante Publique. 1998 Dec;46(6):457-66. Unique Identifier : AIDSLINE MED/99135205; Schwoebel V; Hamers FF; Centre Europeen pour la Surveillance Epidemiologique du sida; (CESES), Hopital National de Saint-Maurice, France.; In 1992, the Maastricht treaty gave specific responsibilities to the European Community in the field of research, information and health education. Several European surveillance systems for infectious diseases have been organised. The surveillance of AIDS was set up in 1984 after the emergence of this new disease. Sev
[A patient with rapidly progressing renal failure, florid syphilis and positive HIV serology]: Schweiz Med Wochenschr. 1998 Nov 21;128(47):1850-6. Unique Identifier : AIDSLINE MED/99082310; Raz HR; Nickeleit V; Mihatsch MJ; Colombi A; Abteilung fur Nephrologie, Kantonsspital Luzern.; We describe the frist reported case in Switzerland of HIV-associated nephropathy (HIVAN). HIVAN shows a typical combination of clinical findings: black race, proteinuria, large hyper-echogenic kidneys, normal blood pressure, positive HIV serology and no autoantibodies. The his
[Using autoclaved spongiosa]: Unfallchirurg. 1998 Nov;101(11):870-6. Unique Identifier : AIDSLINE MED/99082690; Kuner EH; Schlickewei W; Huber-Lang M; Schaefer DJ; Laubenberger J; Abteilung Unfallchirurgie, Chirurgische Universitatsklinik; Freiburg.; Since transmission of HIV through allogenic bone grafts has been established, the concept of cryopreservation of allogenic bone had to be reconsidered. The strict guidelines of the scientific board of the Bundesarztekammer of 1990 are very labour-, time- and money-intensive. We have therefore moved to autoclaving allo
[Intravenous drug use and transmission of AIDS (editorial)]: Srp Arh Celok Lek. 1998 Nov-Dec;126(11-12):417-22. Unique Identifier : AIDSLINE MED/99119581; Suvakovic V
[Transmission of acquired immunodeficiency syndrome among intravenous drug abusers in Belgrade]: Srp Arh Celok Lek. 1998 Nov-Dec;126(11-12):437-45. Unique Identifier : AIDSLINE MED/99119584; Suvakovic V; Kavaric J; Alcaz S; Zavisic L; Jankovic T; Djokic D; Institute of Infectious and Tropical Diseases, Clinical Centre of; Serbia, Belgrade.; The prevalence of HIV infection among intravenous drug addicts (IVDAs) was 11% in Belgrade in 1997 (500 IVDAs). There are only two ways of transmission of HIV infection among IVDAs: the use of contaminated needles and syringes and sexual intercourse with an infected partner. We established in the counselling office fo
[Perception of risk for infection with the human immunodeficiency virus]: Srp Arh Celok Lek. 1998 Nov-Dec;126(11-12):446-9. Unique Identifier : AIDSLINE MED/99119585; Vukovic D; Bjegovic V; Cucic V; Marinkovic J; Babic D; Institute of Social Medicine, Statistics and Health Research,; School of Medicine University, Belgrade.; Prevention of AIDS is very complex and requires, apart from basic knowledge about modes of transmission and protection, individual awareness of personal risk of infection and modification of one s risky behavior. Perception of risk has been suggested as an important element of sexual behavior change among people who e
AIDS and informed consent [letter]: S Afr Med J. 1998 Dec;88(12):1535-6. Unique Identifier : AIDSLINE MED/99129096; van Niekerk JJ
Hepatitis C virus infection in Chicago women with or at risk for HIV infection: evidence for sexual transmission.: Sex Transm Dis. 1998 Nov;25(10):527-32. Unique Identifier : AIDSLINE MED/99074059; Hershow RC; Kalish LA; Sha B; Till M; Cohen M; University of Illinois at Chicago School of Public Health and; College of Medicine, 60612, USA.; BACKGROUND AND OBJECTIVES: The importance of sexual transmission of hepatitis C virus (HCV) infection is unclear. We attempted to define its role in women with or at risk for HIV infection. GOAL OF THIS STUDY: To ascertain if high-risk sexual behavior was independently associated with HCV infection. STUDY DESIGN: Risk
Risk assessment to improve targeting of HIV counseling and testing services for STD clinic patients.: Sex Transm Dis. 1998 Nov;25(10):539-43. Unique Identifier : AIDSLINE MED/99074061; Chen Z; Branson B; Ballenger A; Peterman TA; Fuzhou Health and Quarantine Bureau, People's Republic of China.; BACKGROUND AND OBJECTIVE: To determine whether self-administered risk assessment could improve targeting of HIV counseling and testing in an STD clinic. STUDY DESIGN: Computerized records from the Prince George s County, Maryland, STD clinic from 1993 through 1996 were used to develop and test models for predicting a
Treponemal specific tests for the serodiagnosis of syphilis. Syphilis and HIV Study Group.: Sex Transm Dis. 1998 Nov;25(10):549-52. Unique Identifier : AIDSLINE MED/99074063; Augenbraun M; Rolfs R; Johnson R; Joesoef R; Pope V; SUNY-Health Science Center at Brooklyn, New York 11203, USA.; augenm23Ahscbklyn.edu.; OBJECTIVES: To determine the rate of concordance of the Microhemagglutination Assay for Antibodies to T. pallidum (MHA-TP) and the Fluorescent Treponemal Antibody-Absorption test (FTA-ABS) prior to therapy in patients with early stage syphilis and to assess the incidence of and associated risk factors for seroreversio
Group counseling to prevent sexually transmitted disease and HIV: a randomized controlled trial.: Sex Transm Dis. 1998 Nov;25(10):553-60. Unique Identifier : AIDSLINE MED/99074064; Branson BM; Peterman TA; Cannon RO; Ransom R; Zaidi AA; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; OBJECTIVE: To compare prevention effectiveness of multisession group counseling with standard HIV prevention counseling for reducing risk behaviors and new sexually transmitted diseases (STDs). METHODS: Small groups of consenting STD clinic patients were randomized to four 1-hour small group counseling interventions b
Partner notification in the real world: a four site time-allocation study.: Sex Transm Dis. 1998 Nov;25(10):561-8. Unique Identifier : AIDSLINE MED/99074065; Macke BA; Hennessy M; McFarlane MM; Bliss MJ; Behavioral Interventions Research Branch, Division of STD; Prevention, National Center for HIV, STD, and TB Prevention,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; BACKGROUND AND OBJECTIVES: Although partner notification has been a long-standing intervention and prevention strategy for sexually transmitted diseases (STD), variations in partner notification practices across sites have never been documented. GOALS OF THE STUDY: To describe provider-assisted partner notification pr
The association of false-positive rapid plasma reagin results and HIV infection.: Sex Transm Dis. 1998 Nov;25(10):569-71. Unique Identifier : AIDSLINE MED/99074066; Joyanes P; Borobio MV; Arquez JM; Perea EJ; Department of Microbiology, University Hospital V. Macarena,; Seville, Spain.; BACKGROUND AND OBJECTIVES: To study the relationship between a false positive rapid plasma reagin (RPR) result (FP), syphilis, and HIV infection in our patients. METHODS: A prospective study of the incidence of FP tests and syphilis in the general population and its relationship to HIV infection over a period of 6 mon
Open and laparoscopic cholecystectomy in acquired immunodeficiency syndrome: indications and results in fifty-three patients.: Surgery. 1999 Feb;125(2):172-7. Unique Identifier : AIDSLINE MED/99150813; Ricci M; Puente AO; Rothenberg RE; Shapiro K; de Luise C; LaRaja RD; Department of Surgery and Surgical Research, Cabrini Medical; Center/The Mount Sinai School of Medicine, New York, NY 10003,; USA.; BACKGROUND: Although acute cholecystitis is one of the most common indications for abdominal surgery in patients with acquired immunodeficiency syndrome (AIDS), previous studies have reported disappointingly high morbidity and mortality among those patients who have undergone cholecystectomy. The aims of this study we
Plasma vitamins A and E in HIV-positive patients.: Subcell Biochem. 1998;30:145-55. Unique Identifier : AIDSLINE MED/99131305; Constans J; Peuchant E; Sergeant C; Conri C; Service de Medecine Interne et Pathologie Vasculaire, Hopital; Saint-Andre, Bordeaux, France.
Analysis of lymphocyte subpopulations in cerebrospinal fluid and peripheral blood in patients with multiple sclerosis and inflammatory diseases of the nervous system.: Acta Neurol Scand. 1998 Nov;98(5):310-3. Unique Identifier : AIDSLINE MED/99073810; Oreja-Guevara C; Sindern E; Raulf-Heimsoth M; Malin JP; Department of Neurology, Ruhr-University of Bochum, BG Kliniken; Bergmannsheil, Germany.; We analysed different subsets of lymphocytes from peripheral blood (PB) and cerebrospinal fluid (CSF) by flow cytometry in order to determinate alterations in patients with multiple sclerosis (MS) in acute relapse and viral inflammatory neurological disease (IND). We found increased levels of adhesion molecules (LFA-1
Oral health care issues in HIV disease: developing a core curriculum for primary care physicians.: J Am Board Fam Pract. 1998 Nov-Dec;11(6):434-44. Unique Identifier : AIDSLINE MED/99091226; Sifri R; Diaz VA Jr; Gordon L; Glick M; Anapol H; Goldschmidt R; Greenspan D; Sadovsky R; Turner B; Rabinowitz HK; Department of Family Medicine, Center for Medical Education; Research and Policy, Jefferson Medical College of Thomas; Jefferson University, Philadelphia, PA 19107, USA.; BACKGROUND: Given the high occurrence of oral manifestations in patients infected with human immunodeficiency virus (HIV), the relative ease in recognizing these manifestations on physical examination, and their potential impact on the health care and quality of life in these patients, it is critical to provide adequa
Extranodal non-Hodgkin lymphoma involving the muscles of mastication [see comments]: AJNR Am J Neuroradiol. 1998 Nov-Dec;19(10):1849-51. Unique Identifier : AIDSLINE MED/99089931; Chong J; Som PM; Silvers AR; Dalton JF; Department of Radiology, Mount Sinai School of Medicine, City; University of New York, NY, USA.; Involvement of the skeletal muscle by non-Hodgkin lymphoma (NHL) is unusual. The most commonly affected muscles are those of the extremities, pelvis, and gluteal regions; rarely are the muscles in the head and neck involved. We report the clinical, CT, and MR imaging findings in two patients with extranodal NHL in the
Multifocal varicella-zoster virus leukoencephalitis in a patient with AIDS: MR findings.: AJNR Am J Neuroradiol. 1998 Nov-Dec;19(10):1897-9. Unique Identifier : AIDSLINE MED/99089939; Aygun N; Finelli DA; Rodgers MS; Rhodes RH; Department of Radiology, MetroHealth Medical Center/Case Western; Reserve University School of Medicine, Cleveland, OH 44109, USA.; We describe a patient with AIDS who presented with an acute encephalitis caused by infection with varicella-zoster virus. The hemorrhagic, necrotizing encephalitis had an unusual MR appearance, with innumerable discrete, small, targetlike lesions in the right cerebral hemisphere, which were coalescent in the posterior
HHS awards $479 million in grants for HIV/AIDS care and support services [news]: Am Fam Physician. 1999 Feb 1;59(3):518. Unique Identifier : AIDSLINE MED/99154043
The changing spectrum of HIV care.: Am Fam Physician. 1999 Feb 1;59(3):545-8. Unique Identifier : AIDSLINE MED/99154046; Reyes EM; Liljestrand P; Goldschmidt RH; University of California, San Francisco, School of Medicine, USA.
HIV testing for all pregnant women [news]: Am Fam Physician. 1999 Feb 1;59(3):701, 704. Unique Identifier : AIDSLINE MED/99154054
Implantation metastasis of primary central nervous system lymphoma complicating radiotherapy outcome.: Am J Clin Oncol. 1999 Feb;22(1):29-31. Unique Identifier : AIDSLINE MED/99148242; Roa WH; Kim D; Halls SB; Murray B; Department of Radiation Oncology, Cross Cancer Institute,; Edmonton, Alberta, Canada.; Computed tomography-guided stereotactic biopsy is commonly used in the diagnosis of brain lesions. An uncommonly reported risk of the procedure is the potential of implantation metastasis. This phenomenon has been reported in central nervous system malignancies. Although the role of prophylactic local radiotherapy at
Non-Hodgkin lymphoma in acquired immunodeficiency syndrome manifesting as bilateral hypopyon.: Am J Clin Oncol. 1999 Feb;22(1):82-3. Unique Identifier : AIDSLINE MED/99148255; Jan NA; Einzig AI; Suhrland MJ; Wiernik PH; Albert Einstein Cancer Center, Montefiore Medical Center, Bronx,; New York 10467, USA.; Orbital lymphoma is a rare event. This is the first case report of a patient with acquired immunodeficiency syndrome-associated lymphoma, in which orbital lymphoma presented as bilateral hypopyon. This was the terminal manifestation of a highly aggressive disease, which progressed despite appropriate treatment.
Epidemiology of drug-resistant tuberculosis in Texas.: Am J Epidemiol. 1999 Feb 15;149(4):359-65. Unique Identifier : AIDSLINE MED/99148346; Taylor JP; Bergmire-Sweat D; Suarez L; Tuberculosis Elimination Division, Bureau of Communicable Disease; Control, Texas Department of Health, Austin 78756, USA.; During 1987-1996, over 22,000 tuberculosis cases were reported in Texas, at an average annual incidence rate of 12.5 cases per 100,000 population. Counties with the highest rates were located along the Mexico-Texas border and in northwestern Texas. Nine percent of cases were resistant to at least one of the five first
Corneal endothelial deposits in children positive for human immunodeficiency virus receiving rifabutin prophylaxis for Mycobacterium avium complex bacteremia.: Am J Ophthalmol. 1999 Feb;127(2):164-9. Unique Identifier : AIDSLINE MED/99153629; Smith JA; Mueller BU; Nussenblatt RB; Whitcup SM; Laboratory of Immunology, National Eye Institute, National; Institutes of Health, Bethesda, Maryland 20892-1858, USA.; jmas@box-j.nih.gov; PURPOSE: To assess the potential ocular effects of prophylactic administration of rifabutin in children with symptomatic human immunodeficiency virus (HIV) infection and CD4 counts less than 50 cells per mm3. METHODS: Twenty-five children with HIV infection were enrolled in a phase I-II study of prophylactic administr
Resolution of microsporidial sinusitis and keratoconjunctivitis by itraconazole treatment.: Am J Ophthalmol. 1999 Feb;127(2):210-2. Unique Identifier : AIDSLINE MED/99153639; Rossi P; Urbani C; Donelli G; Pozio E; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.; PURPOSE: To report successful treatment of ocular infection caused by the microsporidium Encephalitozoon cuniculi in a person with acquired immunodeficiency syndrome (AIDS) and nasal and paranasal sinus infection. METHOD: Case report. RESULTS: Microsporidial infection in a person with AIDS and with chronic sinusitis a
Comparison of intraocular to plasma HIV-1 viral burden in patients with cytomegalovirus retinitis.: Am J Ophthalmol. 1999 Feb;127(2):221-3. Unique Identifier : AIDSLINE MED/99153645; Ciulla TA; Schnizlein-Bick CT; Danis RP; Frank MO; Wheat LJ; Department of Ophthalmology, Indiana University School of; Medicine, Indianapolis 46202, USA.; PURPOSE: To determine the relationship between plasma and intraocular human immunodeficiency virus-1 (HIV-1) viral loads in 12 consecutive patients undergoing ganciclovir implant surgery for cytomegalovirus ( CMV ) retinitis. M
Association of simian virus 40 with a central nervous system lesion distinct from progressive multifocal leukoencephalopathy in macaques with AIDS.: Am J Pathol. 1999 Feb;154(2):437-46. Unique Identifier : AIDSLINE MED/99149648; Simon MA; Ilyinskii PO; Baskin GB; Knight HY; Pauley DR; Lackner AA; Division of Comparative Pathology, New England Regional Primate; Research Center, Harvard Medical School, Southborough,; Massachusetts 01772-9102, USA. meredith_simon@hms.harvard.edu; The primate polyomavirus SV40 is known to cause interstitial nephritis in primary infections and progressive multifocal leukoencephalopathy (PML) upon reactivation of a latent infection in SIV-infected macaques. We now describe a second central nervous system manifestation of SV40: a meningoencephalitis affecting cere
Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells.: Am J Pathol. 1999 Feb;154(2):481-94. Unique Identifier : AIDSLINE MED/99149652; Carson MJ; Reilly CR; Sutcliffe JG; Lo D; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.; Inappropriate immune responses, thought to exacerbate or even to initiate several types of central nervous system (CNS) neuropathology, could arise from failures by either the CNS or the immune system. The extent that the inappropriate appearance of antigen-presenting cell (APC) function contributes to CNS inflammatio
Condom use in female sex workers in Italy [letter]: Am J Public Health. 1999 Jan;89(1):108. Unique Identifier : AIDSLINE MED/99141952; Spina M; Tirelli U
The protective effect of condoms and nonoxynol-9 against HIV infection: a response to Wittkowski and colleagues [letter]: Am J Public Health. 1999 Jan;89(1):108-10. Unique Identifier : AIDSLINE MED/99141953; Feldblum PJ; Weir SS; Cates W Jr
Universal HIV screening at a major metropolitan TB clinic: HIV prevalence and high-risk behaviors among TB patients.: Am J Public Health. 1999 Jan;89(1):73-5. Unique Identifier : AIDSLINE MED/99141941; Weis SE; Foresman B; Cook PE; Matty KJ; Department of Medicine, University of North Texas Health Science; Center, Fort Worth 76107, USA. sweis@hsc.unt.edu; OBJECTIVES: This study assessed the outcome of implementing a policy of universal screening of patients with tuberculosis (TB) for HIV infection at a major metropolitan public health TB clinic. METHODS: HIV serologic testing was completed on 768 (93%) of 825 eligible patients. Ninety-eight HIV-positive cases (13%) wer
Reducing AIDS risk among port workers in Santos, Brazil.: Unique Identifier : AIDSLINE MED/99141942; Hearst N; Lacerda R; Gravato N; Hudes ES; Stall R; OBJECTIVES: This study examined the impact of worksite-based AIDS prevention program among port workers in Santos, Brazil , on sexual risk behavior for HIV infection. METHODS: Male port workers (n = 226) were followed in a 3-wave prospective cohort study. A multifaceted intervention
Impaired glucose tolerance in HIV-positive patients receiving and those not receiving protease inhibitors [letter]: Ann Intern Med. 1999 Jan 19;130(2):162-3. Unique Identifier : AIDSLINE MED/99150021; Mauss S; Wolf E; Jaeger H
The costs, clinical benefits, and cost-effectiveness of screening for cervical cancer in HIV-infected women.: Ann Intern Med. 1999 Jan 19;130(2):97-107. Unique Identifier : AIDSLINE MED/99150006; Goldie SJ; Weinstein MC; Kuntz KM; Freedberg KA; Center for Risk Analysis, Department of Health Policy and; Management, Harvard University School of Public Health, Boston,; Massachusetts 02115-5924, USA. sgoldie@hsph.harvard.edu; BACKGROUND: Women with HIV infection have a higher risk for cervical squamous intraepithelial lesions than do women without HIV infection, and the optimal regimen for cervical cancer screening in these women is uncertain. OBJECTIVE: To assess the net health consequences, costs, and cost-effectiveness of various screen
Leg ischemia in a patient receiving ritonavir and ergotamine [letter]: Ann Intern Med. 1999 Feb 16;130(4 Pt 1):329-30. Unique Identifier : AIDSLINE MED/99149976; Montero A; Giovannoni AG; Tvrde PL
Summary of the II International Symposium on Cytomegalovirus.: Antiviral Res. 1998 Oct;39(3):141-62. Unique Identifier : AIDSLINE MED/99049702; de Jong MD; Galasso GJ; Gazzard B; Griffiths PD; Jabs DA; Kern ER; Spector SA; Department of Clinical Virology, Academic Medical Centre,; University of Amsterdam, The Netherlands. m.d.dejong@amc.uva.nl; Human cytomegalovirus (HCMV) is a highly species-specific DNA virus belonging to the Betaherpesvirinae subfamily of the herpesviridae family. Like other herpesviruses, primary infection with HCMV is followed by persistence of the virus in a latent form. The sites of latency are sti
Highly active antiretroviral therapy results in a decrease in CD8+ T cell activation and preferential reconstitution of the peripheral CD4+ T cell population with memory rather than naive cells.: Antiviral Res. 1998 Oct;39(3):163-73. Unique Identifier : AIDSLINE MED/99049703; Evans TG; Bonnez W; Soucier HR; Fitzgerald T; Gibbons DC; Reichman RC; Infectious Diseases Unit, University of Rochester, NY, USA.; OBJECTIVE: Highly active antiretroviral therapy (HAART) can produce marked increases in peripheral blood CD4+ T cells and decreases in HIV plasma RNA copy numbers. However, it is not clear whether these absolute changes will be accompanied by a recovery in the known naive CD4+ T cell depletion or a decrease in the mar
CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.: Antiviral Res. 1998 Oct;39(3):175-87. Unique Identifier : AIDSLINE MED/99049704; Schols D; Proost P; Struyf S; Wuyts A; De Meester I; Scharpe S; Van Damme J; De Clercq E; Laboratory of Experimental Chemotherapy, Rega Institute for; Medical Research, Leuven, Belgium.; dominique.schols@rega.kuleuven.ac.be; The natural CC-chemokine RANTES(3-68), missing two NH2-terminal residues, has been isolated from leukocytes and tumor cells. The highly specific aminopeptidase dipeptidyl peptidase IV (DPP IV), also called CD26, was shown to be responsible for this NH2-terminal truncation of RANTES. Here it is reported that CD26/DPP I
The utility of entoptic perimetry as a screening test for cytomegalovirus retinitis.: Arch Ophthalmol. 1999 Feb;117(2):202-7. Unique Identifier : AIDSLINE MED/99155169; Plummer DJ; Banker A; Taskintuna I; Azen SP; Sample PA; LaBree L; Freeman WR; Shiley Eye Center, Department of Ophthalmology, School of; Medicine, University of California San Diego, La Jolla; 92093-0946, USA. dplummer@ucsd.edu; OBJECTIVE: To determine the sensitivity and specificity of entoptic perimetry as a noninvasive test for detecting retinal damage due to peripheral cytomegalovirus ( CMV ) retinitis. DESIGN: A masked study comparing entoptic per
Eyelid nodule: a sentinel lesion of disseminated cryptococcosis in a patient with acquired immunodeficiency syndrome.: Arch Ophthalmol. 1999 Feb;117(2):271-2. Unique Identifier : AIDSLINE MED/99155185; Coccia L; Calista D; Boschini A
Isolation, characterization, and distribution of a 24-kDa proteoglycan in the urine of cachectic cancer and AIDS patients.: Biochem Biophys Res Commun. 1999 Jan 27;254(3):642-6. Unique Identifier : AIDSLINE MED/99120915; Figueroa JE; Vijayagopal P; Prasad A; Schapira DV; Prasad C; Department of Medicine, LSU Medical Center, New Orleans,; Louisiana, 70112, USA.; Substantial weight loss in individuals with AIDS or cancer is associated with a poor prognosis and increased mortality. We have isolated and partially characterized a proteoglycan (named azaftig) from the urine of a cancer patient experiencing weight loss. Furthermore, we have raised a polyclonal antibody to azaftig i
Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies: CD4+ T cells cause muscle cell injury directly in polymyositis.: Arthritis Rheum. 1999 Feb;42(2):291-8. Unique Identifier : AIDSLINE MED/99148790; Sugiura T; Murakawa Y; Nagai A; Kondo M; Kobayashi S; Shimane Medical University, Izumo, Japan.; OBJECTIVE: To investigate the involvement of the Fas/Fas ligand (Fas/FasL) system in the inflammatory myopathies. METHODS: Frozen muscle sections obtained from 7 patients with polymyositis (PM), 4 patients with dermatomyositis (DM), and 3 controls were studied by immunochemistry. Apoptosis was detected by DNA electrop
[Placental infection in Rwanda: comparison an HIV infected population and a control population]: Ann Pathol. 1998 Dec;18(6):466-72. Unique Identifier : AIDSLINE MED/99161065; Hofman V; Ladner J; Tran AT; Rampal A; Chevallier A; Boissy C; Michiels JF; de Clercq A; Dabis F; Hofman P; Service d'Anatomie Pathologique, Hopital Pasteur, Nice.; We report an histological study from term placentas of 286 HIV positive women born in Rwanda . We observed chorioamnionitis without any pathogen in 15% of the cases, cocci Gram positive infection in 12 observations and malaria infection in 75% of placentas. We noted 71 cases of acti
Trials in developing countries.: Asian Pac J Allergy Immunol. 1998 Jun-Sep;16(2-3):137-9. Unique Identifier : AIDSLINE MED/99092779; Phanuphak P; Department of Medicine, Faculty of Medicine, Chulalongkorn; University and The Thai Red Cross AIDS Research Centre, Bangkok.; Good clinical trials can be carried out in the developing countries but ethical issues concerning the trials are frequently brought up for international debate. The concern has its own merit but can be amended if investigators (local and international) pay serious attention to these criticisms and work out the way tha
Decreased CD4+/CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers.: Unique Identifier : AIDSLINE MED/99092771; Bachtiar EW; Cornain S; Siregar B; Raharjo TW; Department of Oral Biology, Faculty of Dentistry, University of; Indonesia, Jakarta.; The etiology of recurrent aphthous ulcers (RAU) has not been clearly defined. However, the results of several studies indicated the evidence of the role of immunological factors. The association between the regulator and effector component of the immune system in RAU needs clarifying by comparing major and minor type
CD4+ T cells orchestrate both amplification and deletion of CD8+ T cells.: Crit Rev Immunol. 1998;18(6):569-94. Unique Identifier : AIDSLINE MED/99079087; Frasca L; Piazza C; Piccolella E; Department of Cellular and Developmental Biology, La Sapienza; University of Rome, Italy.; This review focuses on the role of CD4+ T cells in regulating immune responses, orchestrating both the amplification and deletion of immune cells, particularly CD8+ T cells. These two functions, which represent only an apparent contradiction, appear to be two faces of the same process of regulation. In fact, because t
Long-term telomere dynamics: modest increase of cell turnover in HIV-infected individuals followed for up to 14 years.: Pathobiology. 1999;67(1):34-8. Unique Identifier : AIDSLINE MED/99134181; Feng YR; Biggar RJ; Gee D; Norwood D; Zeichner SL; Dimitrov DS; Laboratory of Experimental and Computational Biology, National; Cancer Institute-FCRDC, NIH, Frederick, MD 21702-1201, USA.; To quantify the long-term dynamics of telomere lengths and the effect of HIV infection on lymphocyte turnover rates, we measured in a blinded study longitudinal samples from 6 individuals using a highly accurate method based on two-dimensional calibration of DNA sizes. For two uninfected controls followed 8 and 10 yea
4th International Congress on Drug Therapy in HIV infection. Glasgow, United Kingdom, 8-12 November 1998. Abstracts.: AIDS. 1998 Nov;12 Suppl 4:S1-113. Unique Identifier : AIDSLINE MED/99164662
GFP:HIV-1 protease production and packaging with a T4 phage expression-packaging processing system.: Biotechniques. 1998 Dec;25(6):1008-12. Unique Identifier : AIDSLINE MED/99080189; Mullaney JM; Black LW; University of Maryland School of Medicine, Baltimore 21202-1503,; USA.; A bacteriophage T4-derived protein expression, packaging and processing system was used to create recombinant phage that encode, produce and package a protein composed of human HIV-1 protease fused to green fluorescent protein (GFP). The fusion protein is targeted within the phage capsid by an N-terminal capsid target
Adaptation of the fluorogenic 5'-nuclease chemistry to a PCR-based reverse transcriptase assay.: Biotechniques. 1998 Dec;25(6):972-5. Unique Identifier : AIDSLINE MED/99080185; Maudru T; Peden KW; FDA, Bethesda, MD 20892, USA.
Do women with HIV infection consult with their GPs? [letter]: Br J Gen Pract. 1998 Aug;48(433):1525-6. Unique Identifier : AIDSLINE MED/99148855; Moss TR; Goy L; Hawkswell J; Brar H
The role of the GP in the care of people with HIV and AIDS [letter]: Br J Gen Pract. 1998 Aug;48(433):1526-7. Unique Identifier : AIDSLINE MED/99148856; Dunford A
Interaction of human immunodeficiency virus type 1 envelope glycoprotein V3 loop with CCR5 and CD4 at the membrane of human primary macrophages.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1605-15. Unique Identifier : AIDSLINE MED/99085860; Rabehi L; Seddiki N; Benjouad A; Gluckman JC; Gattegno L; Laboratoire de Biologie Cellulaire, Faculte de Medecine,; Universite Paris-Nord, Bobigny, France.; We show that infection of primary monocyte-derived macrophages (MDMs) and blood lymphocytes (PBLs) by human immunodeficiency virus type 1 (HIV-1) R5 strains, but not that of PBLs by X4 strain HIV-1LAI, is inhibited by beta-chemokines RANTES and MIP-1alpha. A biotinylated disulfide-bridged peptide mimicking the complet
Inhibition of HIV type 1 infection with a RANTES-IgG3 fusion protein.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1617-24. Unique Identifier : AIDSLINE MED/99085861; Challita-Eid PM; Klimatcheva E; Day BT; Evans T; Dreyer K; Rimel BJ; Rosenblatt JD; Planelles V; Department of Medicine, University of Rochester Cancer Center,; New York 14642, USA.; The natural ligands for the chemokine receptors CCR5 (RANTES, MIP-1alpha, and MIP-1beta) and CXCR4 (SDF-1) can act as potent inhibitors of infection by the human immunodeficiency virus type 1 (HIV-1) at the level of viral entry. Unlike antibody-mediated inhibition, chemokine-mediated inhibition is broadly effective. D
A cocktail of Mycobacterium bovis BCG recombinants expressing the SIV Nef, Env, and Gag antigens induces antibody and cytotoxic responses in mice vaccinated by different mucosal routes.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1625-33. Unique Identifier : AIDSLINE MED/99085862; Lagranderie M; Winter N; Balazuc AM; Gicquel B; Gheorghiu M; Laboratoire du BCG, Institut Pasteur, Paris, France.; Recombinant live Mycobacterium bovis BCG strains (rBCG) expressing different human immunodeficiency virus (HIV) or simian immunodeficiency (SIV) antigens could be good candidates for the development of vaccines against AIDS. To develop effective HIV/SIV vaccines, humoral and cellular immune responses directed against
Correlates of apoptosis of CD4+ and CD8+ T cells in tonsillar tissue in HIV type 1 infection.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1635-43. Unique Identifier : AIDSLINE MED/99085863; Rosok BI; Brinchmann JE; Stent G; Bjerknes R; Voltersvik P; Olofsson J; Asjo B; Department of Microbiology and Immunology, the Gade Institute,; University of Bergen, Norway. bard.rosok@gades.uib.no; The immunopathogenesis of human immunodeficiency virus type 1 (HIV-1) infection has been associated with increased death by apoptosis of T cell subsets. In the present study, we have examined correlates of apoptosis of CD4+, CD8S+CD28+, and CD8+CD28- T cells in tonsillar lymphoid tissue in persons with HIV-1. Single-c
The HTLV type I sequence from an asymptomatic German blood donor is related to sequences from South America.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1645-7. Unique Identifier : AIDSLINE MED/99085864; Duwe S; Fleischer C; Knodler B; Kuhnl P; Pauli G; Ellerbrok H; Department of Virology, Robert Koch Institute, Berlin, Germany.; In most parts of Europe only a limited number of sporadic cases of HTLV-I infections have been identified. So far, the few cases found in Germany were individuals from endemic areas or with relations to endemic areas. Here we report an HTLV-I infection from an asymptomatic female
Complete sequence of an infectious molecular clone derived from a Spanish HIV type I isolate.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1649-51. Unique Identifier : AIDSLINE MED/99085865; Olivares I; Casado Herrero C; Iglesias-Ussel MD; Dietrich U; Lopez Galindez C; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, Madrid, Spain.
Zidovudine therapy and HIV type 1 mutations in children with symptomatic HIV type 1 infection: effect of switching to didanosine or zidovudine plus didanosine therapy. Italian Multicenter Study Group on HIV Mutations in Children.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1653-9. Unique Identifier : AIDSLINE MED/99085866; Principi N; Marchisio P; Esposito S; Rossi P; Gattinara GC; Galli L; Gabiano C; Zuccotti GV; Orlandi P; Pediatric Department 4, University of Milan, Italy.; nicpri@imiucca.csi.unimi.it; Type and prevalence of zidovudine (ZDV) resistance mutations in HIV-1-infected children in clinically stable condition and on ZDV monotherapy were analyzed to evaluate the effect of switching to didanosine (ddI) monotherapy or to ZDV plus ddI on the pattern of mutations and on the clinical outcome. Monthly clinical an
Effect of ribavirin on zidovudine efficacy and toxicity in vitro: a concentration-dependent interaction.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1661-7. Unique Identifier : AIDSLINE MED/99085867; Sim SM; Hoggard PG; Sales SD; Phiboonbanakit D; Hart CA; Back DJ; Department of Pharmacology, University of Malaya, Kuala Lumpur,; Malaysia.; Zidovudine (ZDV) is converted to its active triphosphate (ZDVTP) by intracellular kinases. The intermediate ZDV monophosphate (ZDVMP) is believed to play a major role in ZDV toxicity. Manipulation of ZDV phosphorylation is a possible therapeutic strategy for altering the risk-benefit ratio. Here we investigate whether
Role of preimmunization virus sequences in cellular immunity in HIV-infected patients during HIV type 1 MN recombinant gp160 immunization.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1669-78. Unique Identifier : AIDSLINE MED/99085868; Kundu SK; Dupuis M; Sette A; Celis E; Dorner F; Eibl M; Merigan TC; Center for AIDS Research at Stanford, Stanford University Medical; Center, California 94305, USA. kundu@leland.stanford.edu; The effect of patient preimmunization virus sequences on CTL responses during gp160 immunization were studied. Ten HLA-A2+, HIV+ asymptomatic patients with CD4+ T cells >500/mm3 were given two courses of HIV-1 MN rgp160 vaccine over a 2-year period. Envelope epitope-specific CTL responses, using PBMCs, were measured a
Horizontal transmission of human immunodeficiency virus type 1 from father to child.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1679-85. Unique Identifier : AIDSLINE MED/99085869; Salvatori F; De Martino M; Galli L; Vierucci A; Chieco-Bianchi L; De Rossi A; Department of Oncology and Surgical Sciences, AIDS Reference; Center, University of Padova, Italy.; An unusual case of human immunodeficiency virus type 1 (HIV-1) infection in a child was studied. The child, identified as HIV-1 infected at 5 years of age, lived with his parents and a 3-year-old sister. HIV-1 infection was excluded in the mother and sister, but confirmed in the father, who was unaware of his infectio
HIV type 1 subtypes in Malaysia, determined with serologic assays: 1992-1996.: AIDS Res Hum Retroviruses. 1998 Dec 20;14(18):1687-91. Unique Identifier : AIDSLINE MED/99085870; Beyrer C; Vancott TC; Peng NK; Artenstein A; Duriasamy G; Nagaratnam M; Saw TL; Hegerich PA; Loomis-Price LD; Hallberg PL; Ettore CA; Nelson KE; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.; We investigated the molecular epidemiology of HIV-1 subtypes in Malaysia among injecting drug users (IDUs) and sexual transmission risk groups, using serologic and genetic techniques. Frozen sera collected at a general hospital, a blood bank, several drug treatment centers, and a
A survey of potential risk factors for HIV transmission through dental practice in Japan.: Asia Pac J Public Health. 1998;10(1):21-8. Unique Identifier : AIDSLINE MED/99159110; Aizawa F; Yonemitsu M; Akada H; Boutsi E; Aizawa Y; Nishihara T; Hanada N; Department of Preventive Dentistry, Iwate Medical University; School of Dentistry, Morioka, Japan.; A survey was conducted to find potential risk factors for HIV transmission through dental practice. Self-administered questionnaires were distributed to the members of the dental associations of various prefectures and small cities in Japan . A total of 747 questionnaires was returne
HIV/AIDS surveillance system and reported cases of human immunodeficiency virus infection and acquired immunodeficiency syndrome in Japan (1983-1993).: Asia Pac J Public Health. 1995;8(3):162-6. Unique Identifier : AIDSLINE MED/99159089; Miyazaki M; Naemura M; Water Supply and Environmental Sanitation Department, Ministry of; Health and Welfare, Japan.; The Ministry of Health and Welfare forms the AIDS Surveillance Committee, which publishes HIV infection at two-month intervals. As at December 1993, the Ministry of Health and Welfare reported 267 AIDS cases and 1,143 HIV infection cases. Epidemiological data in Japan showed a rapid
Role of local amphotericin B therapy for sino-orbital fungal infections.: Ophthal Plast Reconstr Surg. 1999 Jan;15(1):28-31. Unique Identifier : AIDSLINE MED/99134585; Seiff SR; Choo PH; Carter SR; Ophthalmic Plastic and Reconstructive Surgery Service, Beckman; Vision Center, University of California San Francisco, USA.; PURPOSE: Sino-orbital fungal infections are serious complications of diabetes and immunosuppression. Standard treatments include surgical debridement of the involved tissues with possible orbital exenteration, intravenous antifungal therapy, and improvement of the host s immunocompetence and metabolic state, when poss
Determinants of condom use to prevent HIV infection among youth in Ghana.: J Adolesc Health. 1999 Jan;24(1):63-72. Unique Identifier : AIDSLINE MED/99105373; Adih WK; Alexander CS; Department of Maternal and Child Health, School of Hygiene and; Public Health, Johns Hopkins University, Baltimore, Maryland; 21205, USA.; PURPOSE: To identify the psychosocial and behavioral factors that influence condom use to reduce the risk of human immunodeficiency virus (HIV) infection among young men in Ghana . METHODS: This study used a cross-sectional design in which data on a community-based sample of 601 youn
Treatment of acquired immunodeficiency syndrome-related lymphoma with a standard chemotherapy regimen.: Ann Hematol. 1999 Jan;78(1):9-12. Unique Identifier : AIDSLINE MED/99154866; Aviles A; Nambo MJ; Halabe J; Department of Hematology, Oncology Hospital, National Medical; Center, Mexico, D.F., Mexico. a.aviles@infosel.net.mx; Sixty patients with poor-prognosis malignant lymphoma associated with acquired immunodeficiency syndrome (AIDS) were treated with a standard chemotherapy regimen: cyclophosphamide 600 mg/m2 i.v., day 1; vincristine 1.4 mg/m2 i.v., day 1; epirubicin 70 mg/m2 i.v., day 1; and bleomycin 10 mg/m2 i.v., on day 14. Granuloc
Integrating Buddhism and HIV prevention in U.S. southeast Asian communities.: J Health Care Poor Underserved. 1999 Feb;10(1):100-21. Unique Identifier : AIDSLINE MED/99143554; Loue S; Lane SD; Lloyd LS; Loh L; Department of Epidemiology and Biostatistics, Case Western; Reserve University, School of Medicine, MetroHealth Medical; Center, Cleveland, OH 44109, USA.; Asian Pacific Islander communities in the United States have experienced an alarming increase in HIV infection over the past few years, possibly due to a lack of knowledge and the relative absence of appropriate educational interventions. The authors propose a new approach to the devel
The three leading causes of death in African Americans: barriers to reducing excess disparity and to improving health behaviors.: J Health Care Poor Underserved. 1999 Feb;10(1):45-71. Unique Identifier : AIDSLINE MED/99143551; Feldman RH; Fulwood R; Department of Health Education, University of Maryland, College; Park 20742, USA.; African Americans suffer disproportionately from several major health problems associated with high morbidity and mortality. The 1985 DHHS Secretary s Task Force Report on Blacks and Other Minorities identified six major disease categories of excess deaths for African Americans compared with whites by applying the low
Prophylaxis with weekly versus daily fluconazole for fungal infections in patients with AIDS [see comments]: Clin Infect Dis. 1998 Dec;27(6):1369-75. Unique Identifier : AIDSLINE MED/99085535; Havlir DV; Dube MP; McCutchan JA; Forthal DN; Kemper CA; Dunne MW; Parenti DM; Kumar PN; White AC Jr; Witt MD; Nightingale SD; Sepkowitz KA; MacGregor RR; Cheeseman SH; Torriani FJ; Zelasky MT; Sattler FR; Bozzette SA; University of California, San Diego, USA.; We compared the efficacy of a 400-mg once-weekly dosage versus a 200-mg daily dosage of fluconazole for the prevention of deep fungal infections in a multicenter, randomized, double-blind trial of 636 human immunodeficiency virus-infected patients to determine if a less intensive fluconazole regimen could prevent thes
Antifungal prophylaxis with weekly fluconazole for patients with AIDS [editorial; comment]: Clin Infect Dis. 1998 Dec;27(6):1376-8. Unique Identifier : AIDSLINE MED/99085536; Mylonakis E; Flanigan TP
The incidence and spectrum of AIDS-defining illnesses in persons treated with antiretroviral drugs [see comments]: Clin Infect Dis. 1998 Dec;27(6):1379-85. Unique Identifier : AIDSLINE MED/99085537; Forrest DM; Seminari E; Hogg RS; Yip B; Raboud J; Lawson L; Phillips P; Schechter MT; O'Shaughnessy MV; Montaner JS; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital, Vancouver, British Columbia, Canada.; The incidence and spectrum of primary AIDS-defining illnesses in human immunodeficiency virus-positive patients receiving antiretroviral drugs may have changed since the introduction of newer antiretroviral agents. We performed a retrospective analysis of patients enrolled in the British Columbia Drug Treatment Progra
What is the relevance of antiretroviral therapy that does not include protease inhibitors? [editorial; comment]: Clin Infect Dis. 1998 Dec;27(6):1386-7. Unique Identifier : AIDSLINE MED/99085538; Miller LG; Goetz MB
Does in vitro susceptibility to rifabutin and ethambutol predict the response to treatment of Mycobacterium avium complex bacteremia with rifabutin, ethambutol, and clarithromycin? Canadian HIV Trials Network Protocol 010 Study Group.: Clin Infect Dis. 1998 Dec;27(6):1401-5. Unique Identifier : AIDSLINE MED/99085541; Shafran SD; Talbot JA; Chomyc S; Davison E; Singer J; Phillips P; Salit I; Walmsley SL; Fong IW; Gill MJ; Rachlis AR; Lalonde RG; Department of Medicine, University of Alberta, Edmonton, Canada.; The in vitro susceptibilities of baseline Mycobacterium avium complex (MAC) blood isolates from 86 patients with AIDS who were treated with clarithromycin, ethambutol, and rifabutin were determined to examine whether these results predict bacteriologic response to treatment. No patient received prior prophylaxis with
Serotype distribution and prevalence of resistance to benzylpenicillin in three representative populations of Streptococcus pneumoniae isolates from the coast of Kenya.: Clin Infect Dis. 1998 Dec;27(6):1442-50. Unique Identifier : AIDSLINE MED/99085549; Scott JA; Hall AJ; Hannington A; Edwards R; Mwarumba S; Lowe B; Griffiths D; Crook D; Marsh K; Kenya Medical Research Institute, CRC, Kilifi Research Unit,; Kenya.; As surveillance data from sub-Saharan Africa are few, three representative populations of Streptococcus pneumoniae isolates were examined in Kenya for serotype distribution and Etest minimum inhibitory concentrations (MICs) of benzylpenicillin: (1) 75 lung aspirate or blood culture
Safety and efficacy of intravenous sodium stibogluconate in the treatment of leishmaniasis: recent U.S. military experience.: Clin Infect Dis. 1998 Dec;27(6):1457-64. Unique Identifier : AIDSLINE MED/99085551; Aronson NE; Wortmann GW; Johnson SC; Jackson JE; Gasser RA Jr; Magill AJ; Endy TP; Coyne PE; Grogl M; Benson PM; Beard JS; Tally JD; Gambel JM; Kreutzer RD; Oster CN; Walter Reed Army Medical Center, Washington, D.C. 20307-5001,; USA.; The efficacy and toxicity of sodium stibogluconate (SSG) at a dosage of 20 mg/(kg.d) for either 20 days (for cutaneous disease) or 28 days (for visceral, mucosal, or viscerotropic disease) in the treatment of leishmaniasis is reported. Ninety-six U.S. Department of Defense health care beneficiaries with parasitologica
High incidence of herpes zoster in patients with AIDS soon after therapy with protease inhibitors [see comments]: Clin Infect Dis. 1998 Dec;27(6):1510-3. Unique Identifier : AIDSLINE MED/99085559; Martinez E; Gatell J; Moran Y; Aznar E; Buira E; Guelar A; Mallolas J; Soriano E; Infectious Diseases Unit, Institut d'Investigacions Biomediques; August Pi i Sunyer, Hospital Clinic, Barcelona, Spain.; A high incidence of herpes zoster was noticed among patients with AIDS, shortly after addition of a protease inhibitor to their baseline treatment with nucleoside analogue reverse-transcriptase inhibitors. Within a median follow-up of 64 weeks (range, 34-103 weeks), 14 patients (7%) had a first episode or a recurrence
Potent antiretroviral therapy does more than just decrease viral load [editorial; comment]: Clin Infect Dis. 1998 Dec;27(6):1514-6. Unique Identifier : AIDSLINE MED/99085560; Daar ES
Cellular immune responses to mycobacteria in healthy and human immunodeficiency virus-positive subjects in the United States after a five-dose schedule of Mycobacterium vaccae vaccine.: Unique Identifier : AIDSLINE MED/99085561; von Reyn CF; Marsh BJ; Waddell R; Lein AD; Tvaroha S; Morin P; Modlin JF; Infectious Disease Section, Dartmouth-Hitchcock Medical Center,; Lebanon, New Hampshire 03756, USA.; The safety and immunogenicity of heat-killed Mycobacterium vaccae vaccine were investigated in a pilot study assessing the feasibility of immunization to prevent mycobacterial disease in patients with human immunodeficiency virus (HIV) infection. Fifteen (seven healthy and eight HIV-positive subjects) received five do
Dual microsporidial infection due to Vittaforma corneae and Encephalitozoon hellem in a patient with AIDS.: Clin Infect Dis. 1998 Dec;27(6):1521-4. Unique Identifier : AIDSLINE MED/99085562; Deplazes P; Mathis A; van Saanen M; Iten A; Keller R; Tanner I; Glauser MP; Weber R; Canning EU; Institute of Parasitology, University of Zurich, Switzerland.; A 46-year-old human immunodeficiency virus-infected Swiss citizen living in Tanzania presented with respiratory, abdominal, and urogenital complaints. Microsporidial spores were isolated from urine and a sinunasal aspirate and were propagated in MRC-5 cell cultures. Western blot
Acyclovir-resistant herpes zoster in human immunodeficiency virus-infected patients: results of foscarnet therapy.: Unique Identifier : AIDSLINE MED/99085563; Breton G; Fillet AM; Katlama C; Bricaire F; Caumes E; We retrospectively studied 18 consecutive cases of acyclovir-resistant zoster. All the patients had chronic skin lesions that failed to heal despite treatment with intravenous acyclovir (30 mg/[kg.d]) in 15 cases and oral acyclovir (4 g/d) in three cases for > 10 days. The mean CD4+ cell count was 20 x 10(6)/L. The me
Coccidioidomycosis in Arizona: increase in incidence from 1990 to 1995.: Clin Infect Dis. 1998 Dec;27(6):1528-30. Unique Identifier : AIDSLINE MED/99085564; Ampel NM; Mosley DG; England B; Vertz PD; Komatsu K; Hajjeh RA; University of Arizona College of Medicine, Tucson, USA.; The number of cases of coccidioidomycosis (incidence) reported to the Arizona Department of Health Services increased from 255 (7.0 per 100,000 population) in 1990 to 623 (14.9 per 100,000 population) in 1995 (P
Genital infection due to Mycobacterium genavense in a patient with AIDS.: Clin Infect Dis. 1998 Dec;27(6):1531. Unique Identifier : AIDSLINE MED/99085565; Vergnaud M; Dauga C; Dompmartin A; Malbruny B; Bazin C; Grimont PA; Service de Bacteriologie, Hopital Cote-de-Nacre, Caen, France.
Persistent nephrolithiasis after discontinuation of indinavir therapy.: Clin Infect Dis. 1998 Dec;27(6):1536-7. Unique Identifier : AIDSLINE MED/99085569; Polhemus ME; Aronson NE; Department of Medicine, Walter Reed Army Medical Center,; Washington, D.C. 20307, USA.
Acute human immunodeficiency virus infection with severe respiratory and renal failure.: Clin Infect Dis. 1998 Dec;27(6):1537-8. Unique Identifier : AIDSLINE MED/99085570; Onuchic MH; Campbell WN; Shen CS; Department of Internal Medicine, Union Memorial Hospital,; Baltimore, Maryland 21218, USA.
Gynecomastia associated with indinavir therapy.: Clin Infect Dis. 1998 Dec;27(6):1539-40. Unique Identifier : AIDSLINE MED/99085572; Caeiro JP; Visnegarwala F; Rodriguez-Barradas MC; Section of Infectious Diseases, Veterans Affairs Medical Center,; Houston, Texas, USA.
Isolated cavitary pulmonary Mycobacterium avium complex infection in a patient with AIDS.: Clin Infect Dis. 1998 Dec;27(6):1542-3. Unique Identifier : AIDSLINE MED/99085575; Alisky JM; Schlesinger L; Department of Internal Medicine, University of Iowa Hospitals and; Clinics, Iowa City, USA.
Pulmonary tuberculosis due to Mycobacterium microti in a human immunodeficiency virus-infected patient.: Clin Infect Dis. 1998 Dec;27(6):1543-4. Unique Identifier : AIDSLINE MED/99085576; Foudraine NA; van Soolingen D; Noordhoek GT; Reiss P; National AIDS Therapy Evaluation Centre (NATEC), The Netherlands.
Primary cutaneous acanthamoeba infection in a patient with AIDS.: Clin Infect Dis. 1998 Dec;27(6):1547-8. Unique Identifier : AIDSLINE MED/99085579; Migueles S; Kumar P; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland, USA.
Primary meningococcal conjunctivitis in a human immunodeficiency virus-infected adult.: Clin Infect Dis. 1998 Dec;27(6):1556-7. Unique Identifier : AIDSLINE MED/99085585; Garcia-Lechuz JM; Alcala L; Gijon P; San Juan R; Bouza E; Department of Clinical Microbiology and Infectious Diseases-HIV,; Hospital General Universitario Gregorio, Maranon, Madrid,; Spain.
Abatement of cutaneous Kaposi's sarcoma associated with cidofovir treatment [letter]: Clin Infect Dis. 1998 Dec;27(6):1562. Unique Identifier : AIDSLINE MED/99085589; Simonart T; Noel JC; De Clercq E; Snoeck R
The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy.: J Am Soc Nephrol. 1999 Jan;10(1):51-61. Unique Identifier : AIDSLINE MED/99105315; Barisoni L; Kriz W; Mundel P; D'Agati V; Department of Pathology, Columbia University College of; Physicians and Surgeons, New York, New York, USA.; Podocytes are highly differentiated, postmitotic cells, whose function is largely based on their complex cytoarchitecture. The differentiation of podocytes coincides with progressive expression of maturity markers, including WT-1, CALLA, C3b receptor, GLEPP-1, podocalyxin, and synaptopodin. In collapsing forms of foca
Interferon-gamma upregulates CCR5 expression in cord and adult blood mononuclear phagocytes.: Blood. 1999 Feb 15;93(4):1137-44. Unique Identifier : AIDSLINE MED/99135843; Hariharan D; Douglas SD; Lee B; Lai JP; Campbell DE; Ho WZ; Divisions of Neonatology, the Clinical Immunology Laboratories,; The Children's Hospital of Philadelphia, Philadelphia, PA; The C-C chemokine receptors CCR5 and CCR3 are fusion coreceptors for human immunodeficiency virus (HIV) entry into macrophages. The regulation of their expression influences infectivity by HIV. We report here that interferon-gamma (IFN-gamma) a cytokine that has bidirectional effects on HIV infection of macrophages, s
Coreceptor/chemokine receptor expression on human hematopoietic cells: biological implications for human immunodeficiency virus-type 1 infection.: Blood. 1999 Feb 15;93(4):1145-56. Unique Identifier : AIDSLINE MED/99135844; Lee B; Ratajczak J; Doms RW; Gewirtz AM; Ratajczak MZ; Department of Medicine and the Department of Pathology and; Laboratory Medicine, Hospital of the University of Pennsylvania,; Philadelphia, PA 19104, USA.; The recent discovery of chemokine receptors as coreceptors for human immunodeficiency virus-type 1 (HIV-1) entry offers new avenues for investigating the pathogenesis of acquired immunodeficiency syndrome (AIDS)-related cytopenias. To this end, we sought to (1) phenotype human hematopoietic cells for CD4 and the HIV-1
CD8 T-cell infiltration in extravascular tissues of patients with human immunodeficiency virus infection. Interleukin-15 upmodulates costimulatory pathways involved in the antigen-presenting cells-T-cell interaction.: Blood. 1999 Feb 15;93(4):1277-86. Unique Identifier : AIDSLINE MED/99135859; Agostini C; Zambello R; Facco M; Perin A; Piazza F; Siviero M; Basso U; Bortolin M; Trentin L; Semenzato G; Padua University School of Medicine, Department of Clinical and; Experimental Medicine, Padua Hospital, Padua, Padova, Italy.; Interleukin (IL)-15 regulates the proliferative activity of the CD8(+) T-cell pool in human immunodeficiency virus (HIV)-infected patients, thereby contributing to the maintenance of the CD8(+) T-cell-mediated immune response against HIV in extravascular tissues, including the lung. However, the effects of IL-15 on an
Proliferation and apoptosis-related gene expression in experimental acquired immunodeficiency syndrome-related simian lymphoma.: Blood. 1999 Feb 15;93(4):1364-71. Unique Identifier : AIDSLINE MED/99135868; Castanos-Velez E; Heiden T; Ekman M; Lawrence J; Biberfeld G; Biberfeld P; Immunopathology Laboratory, Karolinska Institute/Hospital, CCK,; Stockholm, Sweden.E.C-Velez@onkpat.ki.se; Lymphomas in 10 cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied with regard to proliferative activity and apoptosis-related gene expression. All were diffuse large-cell lymphomas, showed mono or oligoclonality and a 9/10 diploid cellular DNA content. Expression of a simian homolog
GATA-1 transcription factor transactivates the promoter for CCR5, a coreceptor for human immunodeficiency virus type 1 entry [letter]: Blood. 1999 Feb 15;93(4):1433-5. Unique Identifier : AIDSLINE MED/99173130; Moriuchi M; Moriuchi H; Fauci AS
Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response.: Biosci Biotechnol Biochem. 1998 Dec;62(12):2334-40. Unique Identifier : AIDSLINE MED/99138206; Kobayashi T; Yamamoto M; Hiroi T; McGhee J; Takeshita Y; Kiyono H; Department of Oral Biology, University of Alabama at Birmingham; 35294, USA. sbpharma@mb.infoweb.ne.jp; The effects of arginine on cell proliferation and subsequent T helper (Th) 1 and Th 2 cytokine synthesis by murine Peyer s patch (PP) Th cells in vitro and the influence of arginine on the induction of antigen-specific mucosal and systemic immune responses in vivo were examined. When the PP T cells were stimulated wit
Two cases of idiopathic CD4+ T-lymphocytopenia in elderly patients.: Intern Med. 1998 Oct;37(10):891-5. Unique Identifier : AIDSLINE MED/99054451; Matsuyama W; Tsurukawa T; Iwami F; Wakimoto J; Mizoguchi A; Kawabata M; Osame M; Department of Respiratory Medicine, National Minami-kyushu; Hospital, Kagoshima.; We present 2 cases of idiopathic CD4+ T-lymphocytopenia (ICL) in elderly patients. Case 1, a 73-year-old man, with pneumonia had received several antibiotics with unsuccessful results at another hospital. On admission, his CD4+ T-lymphocyte count was 109/microl and Pneumocystis carinii was detected by bronchoalveolar
Role of cytokines in AIDS wasting [see comments]: Nutrition. 1998 Nov-Dec;14(11-12):853-63. Unique Identifier : AIDSLINE MED/99051993; Chang HR; Dulloo AG; Bistrian BR; Laboratory of Nutrition/Infection, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, Massachusetts 02215-5310,; USA.; There is now a large literature implicating cytokines in the development of wasting and cachexia commonly observed in a variety of pathophysiologic conditions. In the acquired immunodeficiency syndrome (AIDS), cytokines elicited by primary and secondary infections seem to exert subtle and sustained effects on behavior
The wasting syndrome in AIDS: mechanisms and implications [editorial; comment]: Nutrition. 1998 Nov-Dec;14(11-12):867-8. Unique Identifier : AIDSLINE MED/99051996; Grunfeld C
Croatian blood transfusion service in prevention of HIV spread during the war.: Acta Med Croatica. 1998;52(4-5):221-2. Unique Identifier : AIDSLINE MED/99143446; Vuk T; Putarek K; Rojnic N; Margan IG; Balija M; Grgicevic D; Croatian Institute of Transfusion Medicine, Department of; Internal Medicine, Dubrava University Hospital, Zagreb, Croatia.; Beside the war, an unfavorable epidemiological situation and a large number of foreign peace troops that entered the country without having been previously tested for infectious diseases, the number of AIDS cases in our country remained relatively low. The transfusion service played a considerable part in the preventi
Structure-function relations of heparin-mimetic sulfated xylan oligosaccharides: inhibition of human immunodeficiency virus-1 infectivity in vitro.: Glycoconj J. 1998 Jul;15(7):697-712. Unique Identifier : AIDSLINE MED/99096103; Stone AL; Melton DJ; Lewis MS; Laboratory of Developmental and Molecular Immunity, National; Institute of Child Health and Human Development, NIH, Bethesda,; MD 20892, USA. ASTONE@helix.NIH.gov; Heparins/heparan sulfates modulate the function of proteins and cell membranes in numerous biological systems including normal and disease processes in humans. Heparin has been used for many years as an anticoagulant, and anticoagulant heparin-mimetics were developed several decades ago by chemical sulfation of non-ma
Validation of the heat treatment step used in the production of diaspirin crosslinked hemoglobin (DCLHb) for viral inactivation.: Artif Cells Blood Substit Immobil Biotechnol. 1998 Nov;26(5-6):577-82. Unique Identifier : AIDSLINE MED/99060713; Azari M; Ebeling A; Baker R; Burhop K; Camacho T; Estep T; Guzder S; Marshall T; Rohn K; Sarajari R; Blood Substitutes Program, Baxter Healthcare Corporation, Round; Lake, Illinois 60073, USA.; A series of experiments was performed to assess the ability of the heat treatment step used in the manufacture of diaspirin crosslinked hemoglobin (DCLHb) to inactivate viruses. In-process solutions (reaction mixtures after the crosslinking process) from six different manufacturing lots were used as test media in a 1:
PCR-restriction fragment length polymorphism (RFLP) analyses reveal both extensive clonality and local genetic differences in Candida albicans.: Mol Ecol. 1999 Jan;8(1):59-73. Unique Identifier : AIDSLINE MED/99118351; Xu J; Mitchell TG; Vilgalys R; Department of Microbiology, Duke University Medical Center,; Durham, NC 27710, USA. jpxu@duke.edu; Using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to obtain genotypes for the diploid pathogenic yeast, Candida albicans, we analysed 204 C. albicans isolates from three populations of the Duke University community: two from clinical sources [one from patients infected with h
Risk factors for rifampin-monoresistant tuberculosis: A case-control study.: Am J Respir Crit Care Med. 1999 Feb;159(2):468-72. Unique Identifier : AIDSLINE MED/99126666; Sandman L; Schluger NW; Davidow AL; Bonk S; Division of Pulmonary and Critical Care Medicine, Department of; Environmental Medicine, New York University School of Medicine,; New York, USA.; Rifampin is the cornerstone of short-course chemotherapy for the treatment of tuberculosis (TB). Rifampin monoresistance (RMR) is less common than resistance to isoniazid alone or in combination with other antituberculous medications. We conducted a retrospective case-control study to identify risk factors for RMR-TB.
Tuberculous meningitis in South African urban adults.: QJM. 1998 Nov;91(11):743-7. Unique Identifier : AIDSLINE MED/99149076; Karstaedt AS; Valtchanova S; Barriere R; Crewe-Brown HH; Department of Medicine, Chris Hani Baragwanath Hospital, Soweto,; South Africa.; We retrospectively reviewed 56 adults with culture-proven tuberculous meningitis (TBM), investigating clinical signs, cerebrospinal fluid (CSF) findings and outcome. There were 50 patients, aged 18-59 years, 39 with and 11 without human immunodeficiency virus (HIV) infection. Six were aged 60 years or older. Neurologi
Clusters of Pneumocystis carinii pneumonia: analysis of person-to-person transmission by genotyping.: QJM. 1998 Dec;91(12):813-20. Unique Identifier : AIDSLINE MED/99149085; Helweg-Larsen J; Tsolaki AG; Miller RF; Lundgren B; Wakefield AE; Department of Haematology, Rigshospitalet, Copenhagen, Denmark.; Genotyping at the internal transcribed spacer (ITS) regions of the nuclear rRNA operon was performed on isolates of P. carinii sp. f. hominis from three clusters of P. carinii pneumonia among eight patients with haematological malignancies and six with HIV infection. Nine different ITS sequence types of P. carinii sp.
Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection.: J Pediatr Hematol Oncol. 1999 Jan-Feb;21(1):42-6. Unique Identifier : AIDSLINE MED/99154073; Ohga S; Takada H; Honda K; Inamura T; Gondo K; Ohshima K; Yamamoto M; Hara T; Department of Pediatrics, Faculty of Medicine, Kyushu University,; Fukuoka, Japan.; PURPOSE: Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported. PATIENTS AND METHODS: CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly, and abnormal high titers of anti-
Transient hypoplastic anemia caused by primary human parvovirus B19 infection in a previously untreated patient with hemophilia transfused with a plasma-derived, monoclonal antibody-purified factor VIII concentrate.: J Pediatr Hematol Oncol. 1999 Jan-Feb;21(1):74-6. Unique Identifier : AIDSLINE MED/99154081; Matsui H; Sugimoto M; Tsuji S; Shima M; Giddings J; Yoshioka A; Department of Pediatrics, Nara Medical University, Japan.; BACKGROUND: Modern plasma-derived clotting factor concentrates are produced using various virus-inactivation protocols and are assumed to be safer than they were previously with regard to the risk for transmitting viral infections such as human immunodeficiency virus, hepatitis B, and hepatitis C. The risks from virus
Thoracoscopic sympathectomy for ischaemic lesions related to bleomycin therapy for acquired immune deficiency syndrome-related Kaposi's sarcoma.: Eur J Vasc Endovasc Surg. 1999 Feb;17(2):175-7. Unique Identifier : AIDSLINE MED/99162904; Chakfe N; Rey D; Sibilia J; Bronner JF; Beaufigeau M; Partisani M; Massard G; Lang JM; Wihlm JM; Kretz JG; Department of Cardiovascular, Les Hopitaux Universitaires de; Strasbourg, France.
Clarithromycin as a single-modality treatment in mycobacterial avium-intracellular infections.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Jan;87(1):50-4. Unique Identifier : AIDSLINE MED/99124270; Lindeboom JA; de Lange J; van den Akker HP; Department of Oral and Maxillofacial Surgery, Academic Medical; Center and Academic Center for Dentistry (ACTA), University of; Amsterdam, The Netherlands.; Atypical mycobacterial infections are frequently associated with chronic cervical lymphadenopathy, particularly in children between 1 and 5 years of age. The treatment of choice is regarded to be optimal surgical treatment, which often requires wide excision of affected lymph nodes. Although surgical excision is a r
Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor.: Gene Ther. 1998 Dec;5(12):1584-92. Unique Identifier : AIDSLINE MED/99147518; Mageed RA; Adams G; Woodrow D; Podhajcer OL; Chernajovsky Y; Kennedy Institute of Rheumatology, Hammersmith, London, UK.; Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour
Antitumor effect of allogenic fibroblasts engineered to express Fas ligand (FasL).: Gene Ther. 1998 Dec;5(12):1622-30. Unique Identifier : AIDSLINE MED/99147522; Drozdzik M; Qian C; Lasarte JJ; Bilbao R; Prieto J; Department of Medicine, School of Medicine, University of; Navarra, Pamplona, Spain.; Fas ligand is a type II transmembrane protein which can induce apoptosis in Fas-expressing cells. Recent reports indicate that expression of FasL in transplanted cells may cause graft rejection and, on the other hand, tumor cells may lose their tumorigenicity when they are engineered to express FasL. These effects cou
High level inhibition of HIV replication with combination RNA decoys expressed from an HIV-Tat inducible vector.: Gene Ther. 1998 Dec;5(12):1665-76. Unique Identifier : AIDSLINE MED/99147527; Fraisier C; Irvine A; Wrighton C; Craig R; Dzierzak E; Erasmus University Rotterdam, Department of Cell Biology, The; Netherlands.; Intracellular immunization, an antiviral gene therapy approach based on the introduction of DNA into cells to stably express molecules for the inhibition of viral gene expression and replication, has been suggested for inhibition of HIV infection. Since the Tat and Rev proteins play a critical role in HIV regulation,
Bilateral optic neuritis in acute human immunodeficiency virus infection.: Acta Ophthalmol Scand. 1998 Dec;76(6):737-8. Unique Identifier : AIDSLINE MED/99095892; Larsen M; Toft PB; Bernhard P; Herning M; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.; oculus@post1.dknet.dk; PURPOSE: To report a case of acute viral disease accompanied by bilateral optic neuritis with substantial paraclinical evidence that human immunodeficiency virus was the causative agent. METHODS: Clinical and paraclinical examination. Magnetic resonance imaging. RESULTS: Virus and antibody titers as well as reverse ly
Viral and host factors in the prediction of response to interferon-alpha therapy in chronic hepatitis C after long-term follow-up.: Unique Identifier : AIDSLINE MED/99074666; Knolle PA; Kremp S; Hohler T; Krummenauer F; Schirmacher P; Gerken G; Acute infection with hepatitis C virus (HCV) develops into a chronic hepatitis in about 50-70% of patients. Treatment of these patients with interferon-alpha (IFN-alpha) results in a sustained long-term response in only 15-20% but causes numerous unwanted side-effects in a higher percentage of patients. The aim of our
Multi-measurement method comparison of three commercial hepatitis B virus DNA quantification assays.: J Viral Hepat. 1998 Nov;5(6):415-22. Unique Identifier : AIDSLINE MED/99074668; Krajden M; Minor J; Cork L; Comanor L; Toronto Hospital, Department of Laboratory Medicine and; Pathobiology, University of Toronto, Canada.; Serum specimens (327) from patients with chronic hepatitis B were evaluated for hepatitis B virus (HBV) DNA using three commercial assays--Chiron Quantiplex (CA), Digene Hybrid Capture (DA) and Abbott HBV DNA assay (AA). The HBV DNA values obtained following evaluation were used to compare the linearity, responsivenes
[Extension of reporting AIDS cases in Catalonia: study based on requests for CD4 lymphocyte count and prescription of antiretroviral drugs]: Rev Esp Salud Publica. 1998 Nov-Dec;72(6):501-7. Unique Identifier : AIDSLINE MED/99159507; Garcia de Olalla Rizo P; Vall Mayans M; Miret Mases M; Clos Guix R; Casabona Barbara J; Cayla Buqueras JA; Servei d'Epidemiologia, Institut Municipal de Salut Publica,; Barcelona. polalla@imsb.bcn.es; BACKGROUND: To ascertain the degree to which AIDS is officially reported in Catalunya. METHOD: The request for T CD4+ white blood cell counts and the prescribing of antiretroviral drugs in seven university hospitals in Catalunya from January 1, 1994 to June 31, 1994 were used as data-comparison sources. A case was con
Inactivation of intracellular and non-enveloped viruses by a non-ionic naphthalene endoperoxide.: Unique Identifier : AIDSLINE MED/99081211; Dewilde A; Pellieux C; Pierlot C; Wattre P; Aubry JM; Laboratoire de Virologie, Institut Gernez-Rieux, CHU de Lille,; France.; Singlet oxygen (1O2, 1delta(g)) selectively oxidizes many biological targets, some of which, such as viruses, are located intracellularly under in vivo conditions. Considering the short lifetime of 1O2 in aqueous media, it is essential to generate this species in close proximity to the targets. Therefore, a water-solu
HIV/STD transmission in gold-mining areas of Bolivar State, Venezuela: interventions for diagnosis, treatment, and prevention.: Rev Panam Salud Publica. 1999 Jan;5(1):58-65. Unique Identifier : AIDSLINE MED/99159521; Faas L; Rodriguez-Acosta A; Echeverria de Perez G; Prosalud, Contrasida Division, Caracas, Venezuela. faas1@ibm.net
IL-2 expansion of T and NK cells from growth factor-mobilized peripheral blood stem cell products: monocyte inhibition.: J Immunother. 1998 Nov;21(6):409-17. Unique Identifier : AIDSLINE MED/99024867; Ageitos AG; Singh RK; Ino K; Ozerol I; Tarantolo S; Reed EK; Talmadge JE; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198-5660, USA.; The expansion of T and natural killer (NK) cells in growth factor-mobilized peripheral blood stem cell (PSC) products with interleukin-2 ( IL-2 ) requires a reduction in monocyte frequency. Monocytes are enriched with stem cells during apheresis and, in this series of gr
HIV-1 genotypic resistance: automated sequence analysis and interpretation.: Bioinformatics. 1998;14(10):886-7. Unique Identifier : AIDSLINE MED/99128427; Goujon CP; Schneider VM; Jacomet C; Nicolas JC; Service de Microbiologie, Institut Federatif Saint Antoine de; Recherche sur la Sante, Hopital Rothschild, 33 Bd de Picpus,; 75571, Paris, France. goujon@infobiogen.fr; SUMMARY: We present here GRANT ( G enotypic R esistance An alysis T ool), a program that automatically detects resistance-related mutations in HIV-1 protein sequences, and comments on the degree of resistance conferred when possible. This program is easily user-customizable, allowing immediate updates as new resistanc
Serum interferon-gamma (IFN-gamma) in chronic oral candidosis.: Med Mycol. 1998 Oct;36(5):269-73. Unique Identifier : AIDSLINE MED/99140325; Szkaradkiewicz A; Szponar E; Krzeminska-Jaskowiak E; Tulecka T; Department of Medical Microbiology, Karol Marcinkowski University; of Medical Sciences, Poznan, Poland.; Serum IFN-gamma levels were studied in adult patients with chronic oral candidosis, associated with Candida albicans infection. In the group of patients, mean serum IFN-gamma levels (2.74+/-465 pg ml(-1)) were significantly lower than in healthy individuals (9.80+/-1.68 pg ml(-1)). In analysis of the C. albicans strai
Cryptococcus neoformans isolated from human dwellings in Rio de Janeiro, Brazil: an analysis of the domestic environment of AIDS patients with and without cryptococcosis.: Med Mycol. 1998 Oct;36(5):305-11. Unique Identifier : AIDSLINE MED/99140330; Passoni LF; Wanke B; Nishikawa MM; Lazera MS; Laboratorio de Micologia Medica, Hospital Evandro Chagas,; Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.; diphserj@ax.ibase.org.br; One hundred and fifty-four human dwellings in the metropolitan area of Rio de Janeiro, Brazil were studied. A total of 824 samples of indoor dust, outdoor soil and avian droppings were collected. Cryptococcus neoformans var. neoformans was isolated from 20 (13%) dwellings, comprisi
First report of Cryptococcus laurentii meningitis and a fatal case of Cryptococcus albidus cryptococcaemia in AIDS patients.: Med Mycol. 1998 Oct;36(5):335-9. Unique Identifier : AIDSLINE MED/99140334; Kordossis T; Avlami A; Velegraki A; Stefanou I; Georgakopoulos G; Papalambrou C; Legakis NJ; Department of Pathophysiology (AIDS Unit), Medical School,; Athens, Greece.; We report the first case of Cryptococcus laurentii meningitis and a rare case of Cryptococcus albidus cryptococcaemia in AIDS patients. Both infections were treated with amphotericin B and flucytosine. The C. laurentii meningitis was controlled after 2 weeks of treatment with no evidence of infection 20 months later.
Knowledge of HIV/AIDS and emotional adjustment in a cohort of men with haemophilia and HIV infection: final report.: Haemophilia. 1998 Nov;4(6):820-5. Unique Identifier : AIDSLINE MED/99152658; Pasqual Marsettin E; Ciavarella N; Lobaccaro C; Ghirardini A; Puopolo M; Cultraro D; Morfini M; Rocino A; Institute of Psychiatry, University of Bari, Italy.; This study presents the final report of a long-term psychological assessment of men with haemophilia and HIV infection. The knowledge, emotional impact regarding HIV infection and prospective changes over time and the need for psychological support were evaluated. The study group comprised 118 men with haemophilia, 66
Clinical characteristics and blood product usage in AIDS-associated lymphoma in haemophiliacs: a case-control study.: Haemophilia. 1998 Nov;4(6):826-35. Unique Identifier : AIDSLINE MED/99152659; Ragni MV; Belle SH; Bass D; Duerstein S; Kingsley LA; Department of Medicine, University of Pittsburgh, School of; Medicine, The Hemophilia Center of Western Pennsylvania, USA.; In order to determine risk factors associated with the development of AIDS-associated lymphoma (AIDS-NHL) in individuals with haemophilia, we undertook a case-control study of 25 patients with AIDS-NHL identified prospectively in the multicentre Hemophilia Malignancy Study (HMS) and 100 haemophilia controls with AIDS
Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial.: Clin Immunol. 1999 Jan;90(1):100-7. Unique Identifier : AIDSLINE MED/99102724; Boyer JD; Chattergoon MA; Ugen KE; Shah A; Bennett M; Cohen A; Nyland S; Lacy KE; Bagarazzi ML; Higgins TJ; Baine Y; Ciccarelli RB; Ginsberg RS; MacGregor RR; Weiner DB; The Department of Pathology and Laboratory Medicine, University; of Pennsylvania School of Medicine, Philadelphia, Pennsylvania,; 19104, USA.; A DNA-based vaccine containing HIV-1 Env and Rev genes was tested for safety and host immune response in 15 HIV-infected asymptomatic patients with CD4-positive lymphocyte counts >/=500/microl of blood and receiving no antiviral therapy. Successive groups of patients received three doses of vaccine at 30, 100, or 300
Linomide induces apoptotic death of cortical CD4/CD8 double positive thymocytes and thymic atrophy by a corticosteroid-independent pathway.: Clin Immunol. 1999 Jan;90(1):108-14. Unique Identifier : AIDSLINE MED/99102725; Arbel I; Chezen E; Abramsky O; Karpati T; Ovadia H; Mizrachi-Koll R; Karussis D; Laboratory of Neuroimmunology, Hadassah, Hebrew University; Hospital, Jerusalem, IL-91120, Israel.; Linomide is a synthetic immunomodulator which was shown to protect animals against a wide range of experimental autoimmune diseases. In this study we have investigated the effects of Linomide on the thymus in an effort to elucidate the mechanisms by which this immunomodulator suppresses autoimmune reactivity. Normal o
Different therapeutic and bystander effects by intranasal administration of homologous type II and type IX collagens on the collagen-induced arthritis and pristane-induced arthritis in rats.: Clin Immunol. 1999 Jan;90(1):119-27. Unique Identifier : AIDSLINE MED/99102727; Lu S; Holmdahl R; Department of Cell and Molecular Biology, Lund University, Lund,; S-22100, Sweden.; To assess the efficiency of nasally administered cartilage-specific collagens as vaccination against development of arthritis and to ameliorate already established chronic arthritis, experimental models which develop chronic arthritis, pristane-induced arthritis (PIA), and homologous collagen-induced arthritis (CIA) i
Kinetics of lymphocyte apoptosis in macaques infected with different simian immunodeficiency viruses or simian/human immunodeficiency hybrid viruses.: Clin Immunol. 1999 Jan;90(1):141-6. Unique Identifier : AIDSLINE MED/99102730; Reinberger S; Spring M; Nisslein T; Stahl-Hennig C; Hunsmann G; Dittmer U; Department of Virology and Immunology, German Primate Center,; Gottingen, D-37077, Germany.; Increased rates of T-cell apoptosis have been detected in human immunodeficiency virus (HIV)-infected individuals and in the simian immunodeficiency model (SIV) for AIDS research. We have infected macaques with virulent SIV or SIV/HIV hybrid viruses (SHIV) of different pathogenic potentials to study the early kinetics
Regional variation in the lamina propria T cell receptor V beta repertoire in normal human colon.: Clin Immunol. 1999 Jan;90(1):38-46. Unique Identifier : AIDSLINE MED/99102718; Bennet JD; Brown WR; Kotzin BL; Department of Medicine, University of Colorado Health Sciences; Center, Denver, Colorado, 80262, USA.; Lamina propria (LP) T cell populations in the normal human colon contain oligoclonal expansions, but their distribution has not been well studied. We analyzed T cell receptor (TCR) beta-chain (V beta) variable region expression in CD4(+) and CD8(+) peripheral blood T cells and LP T cells from separated colonic segment
Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived.: Clin Immunol. 1999 Jan;90(1):47-54. Unique Identifier : AIDSLINE MED/99102719; Wang M; Saxon A; Diaz-Sanchez D; Division of Clinical Immunology/Allergy, Department of Medicine,; Los Angeles, California, 90095-1680, USA.; IL-4 is central to the formation of IgE and the development of Th2 effector cells, both key features of an allergic response. We have examined IL-4 production early in the formation of an allergic response by using a previously established human in vivo model of allergic rhinitis where allergic subjects are challenged
12th World Conference on AIDS. Geneva, Switzerland, 28 June-3 July 1998]: Clin Ter. 1998 Sep-Oct;149(5):329-30. Unique Identifier : AIDSLINE MED/99161395; Perno CF; Dipartimento di Medicina Sperimentale e Scienze Biochimiche,; Universita Tor Vergata, Roma, Italia.
Computer network home care demonstration: a randomized trial in persons living with AIDS.: Unique Identifier : AIDSLINE MED/99078500; Flatley-Brennan P; PURPOSE: As Internet-based health care applications grow, it is important to determine their acceptability to ill persons and the likely outcomes resulting from their use. This randomized field investigation demonstrated the use and effects of a specialized computer network, the ComputerLink, among persons living with
Women's preferences for vaginal antimicrobial contraceptives. I. Methodology.: Contraception. 1998 Oct;58(4):233-8. Unique Identifier : AIDSLINE MED/99083237; Hardy E; de Padua KS; Jimenez AL; Zaneveld LJ; Department of Obstetrics and Gynecology, Faculty of Medical; Sciences, Universidade Estadual de Campinas (UNICAMP), Sao; Paulo, Brazil. hardy@turing.unicamp.br; Sexually transmitted diseases, including AIDS, and unplanned pregnancies continue to be a serious worldwide problem. A number of organizations are developing woman-controlled vaginal formulations to prevent these problems. However, little information is available regarding the types of products women prefer even thoug
Women's preferences for vaginal antimicrobial contraceptives. II. Preferred characteristics according to women's age and socioeconomic status.: Contraception. 1998 Oct;58(4):239-44. Unique Identifier : AIDSLINE MED/99083238; Hardy E; de Padua KS; Jimenez AL; Zaneveld LJ; Department of Obstetrics and Gynecology, Faculty of Medical; Sciences, Universidade Estadual de Campinas (UNICAMP), Sao; Paulo, Brazil. Hardy@turing.unicamp.br; A study was carried out to identify characteristics that women would want for an idealized vaginal contraceptive, and the possible association of these characteristics with age and socioeconomic status. The study was done in Campinas, Sao Paulo State, Brazil . A total of 635 women w
Women's preferences for vaginal antimicrobial contraceptives. III. Choice of a formulation, applicator, and packaging.: Contraception. 1998 Oct;58(4):245-9. Unique Identifier : AIDSLINE MED/99083239; Hardy E; Jimenez AL; de Padua KS; Zaneveld LJ; Department of Obstetrics and Gynecology, Faculty of Medical; Sciences, Universidade Estadual de Campinas (UNICAMP), Sao; Paulo, Brazil. hardy@turning.unicamp.br; Novel vaginal formulations are under development to combat the increasing incidence of sexually transmitted diseases, including AIDS, and also unplanned pregnancies. A study was performed to determine women s preferences for different dosage forms (gel, cream, ovule/suppository, film, foam, tablet), width, length, and
Women's preferences for vaginal antimicrobial contraceptives. IV. Attributes of a formulation that would protect from STD/AIDS.: Contraception. 1998 Oct;58(4):251-5. Unique Identifier : AIDSLINE MED/99083240; Hardy E; de Padua KS; Osis MJ; Jimenez AL; Zaneveld LJ; Department of Obstetrics and Gynecology, Faculty of Medical; Sciences, Universidade Estadual de Campinas (UNICAMP), Sao; Paulo, Brazil. hardy@turing.unicamp.br; Vaginal formulations may have dual protective activity, against sexually transmitted diseases/AIDS and unplanned pregnancy. The attributes that women find acceptable or unacceptable for such dual protective methods were investigated. More than 50% of the women would not accept messiness, but it was more accepted for
An evaluation of a measure of the proportion of the treatment effect explained by a surrogate marker.: Control Clin Trials. 1998 Dec;19(6):555-68. Unique Identifier : AIDSLINE MED/99091039; Bycott PW; Taylor JM; Department of Biometrics, Parke-Davis Pharmaceutical Research,; Ann Arbor, Michigan, USA.; Time-dependent markers, such as CD4 and viral load, are potential surrogate markers in AIDS clinical trials. A critical issue with surrogate markers is whether changes in these markers explain the beneficial effect of treatment on the real end point of the clinical trial. A statistic to measure the proportion of the t
Gianotti-Crosti syndrome: clinical, serologic, and therapeutic data from nine children.: Cutis. 1998 Dec;62(6):271-4; quiz 286. Unique Identifier : AIDSLINE MED/99095031; Boeck K; Mempel M; Schmidt T; Abeck D; Department of Dermatology and Allergy Biederstein, Technical; University Munich, Germany.; Gianotti-Crosti syndrome (GCS), a self-limiting papulovesicular acrodermatitis often associated with underlying viral infection, is mainly described in children. Nine children with GCS were evaluated with dermatologic examination and serologic tests for viral infections. Therapy was modified according to the subjectiv
[Interaction of psychological and social factors in the care of AIDS virus carriers]: Encephale. 1998 Nov-Dec;24(6):497-502. Unique Identifier : AIDSLINE MED/99135091; Santiago Delefosse M; Paris URA-CNRS 1478, Amiens.; This clinical study of social issues focuses on the interaction of psychological with social factors that affect the behavior toward the care in AIDS. This first part of the research concerns the nurses representations and the nurses unconscious suffering in work. The analysis of twenty interviews and twenty five da
Application of free-flow electrophoresis to the purification of trichosanthin from a crude product of acetone fractional precipitation.: Electrophoresis. 1998 Jun;19(7):1097-103. Unique Identifier : AIDSLINE MED/98324547; Song JF; Liu T; Shen X; Wu GD; Xia QC; Shanghai Institute of Biochemistry, Chinese Academy of Sciences.; The application of free-flow electrophoresis (FFE) to the purification of trichosanthin (TCS) from a crude product of acetone fractional precipitation was investigated. An electrophoresis technique, combining field step electrophoresis (FSE) and zone electrophoresis (ZE) to a one-step procedure, was optimized until a
Characterization of human T-cell leukemia virus type I integrase expressed in Escherichia coli.: Eur J Biochem. 1999 Jan;259(1-2):79-87. Unique Identifier : AIDSLINE MED/99115426; Muller B; Krausslich HG; Heinrich-Pette-Institut fur experimentelle Virologie und; Immunologie an der Universitat Hamburg, Germany.; barbara@hpi.uni-hamburg.de; The C-terminal part of the pol gene of the human T-cell leukemia virus type I (HTLV-I) is predicted to encode the integrase (IN) of the virus; however, this protein has not yet been detected in virions or infected cells. We expressed the putative IN from an infectious molecular clone of HTLV-I in Escherichia coli. Com
Differential effects of CD4+ and CD8+ cells on lymphocyte development from human cord blood cells in murine fetal thymus explants.: Exp Hematol. 1999 Feb;27(2):282-92. Unique Identifier : AIDSLINE MED/99151626; Globerson A; Kollet O; Abel L; Fajerman I; Ballin A; Nagler A; Slavin S; Hur HB; Hagay Z; Sharp A; Lapidot T; Department of Immunology, The Weizman Institute of Science,; Rehovot, Israel. lcglober@weizmann.weizmann.ac.il; The possibility that mature lymphocytes play a role in the regulation of human T cell development was studied in the experimental model of fetal thymus organ cultures (FTOC), by reconstituting lymphocyte-depleted murine fetal thymus (FT) lobe with cells isolated from human umbilical cord blood (CB). Cultures were incu
ACOG committee opinion. Hepatitis virus infections in obstetrician-gynecologists. Number 203, July 1998 (replaces No. 199, February 1998). Committee on Gynecologic Practice. American College of Obstetricians and Gynecologists.: Int J Gynaecol Obstet. 1998 Nov;63(2):203-4. Unique Identifier : AIDSLINE MED/99072151
Population dynamics of HIV-1 inferred from gene sequences.: Genetics. 1999 Feb;151(2):427-38. Unique Identifier : AIDSLINE MED/99126415; Grassly NC; Harvey PH; Holmes EC; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Department of Zoology, University of Oxford, Oxford OX1 3PS,; United Kingdom. grassly@zi.biologie.uni-muenchen.de; A method for the estimation of population dynamic history from sequence data is described and used to investigate the past population dynamics of HIV-1 subtypes A and B. Using both gag and env gene alignments the effective population size of each subtype is estimated and found to be surprisingly small. This may be a r
Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages.: Infect Immun. 1999 Feb;67(2):885-90. Unique Identifier : AIDSLINE MED/99115570; Levitz SM; Nong SH; Seetoo KF; Harrison TS; Speizer RA; Simons ER; Evans Memorial Department of Clinical Research and Department of; Medicine, Boston University Medical Center, Boston,; Massachusetts, USA.slevitz@bu.edu; Recently, we demonstrated that human monocyte-derived macrophages (MDM) treated with chloroquine or ammonium chloride had markedly increased antifungal activity against the AIDS-related pathogen Cryptococcus neoformans. Both of these agents raise the lysosomal pH, which suggested that the increased antifungal activity
Fas-FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice.: Infect Immun. 1999 Feb;67(2):928-35. Unique Identifier : AIDSLINE MED/99115576; Hu MS; Schwartzman JD; Yeaman GR; Collins J; Seguin R; Khan IA; Kasper LH; Departments of Medicine, Dartmouth Medical School, Lebanon, New; Hampshire 03756, USA. Mark.S.Hu@Dartmouth.EDU; Ocular toxoplasmosis is a potentially blinding intraocular inflammation. The intent of this study was to investigate the role of Fas-FasL interaction in a murine model of acquired ocular toxoplasmosis induced by intracameral inoculation of Toxoplasma gondii. Intraocular inflammation, Fas and FasL expression on lymphoc
Intralymphatic interleukin-2 in combination with zidovudine for the therapy of patients with AIDS.: Infection. 1998 Nov-Dec;26(6):368-74. Unique Identifier : AIDSLINE MED/99078555; Harrer T; Schwab J; Struff WG; Schmitt M; Ficker JH; Rodl W; Parsch H; Kalden JR; Gramatzki M; Medizinische Klinik III, Universitat Erlangen-Nurnberg,; Germany.; In a pilot study the safety and therapeutic effects of an immunostimulatory intralymphatic treatment with natural human interleukin-2 ( IL-2 ) in combination with zidovudine were evaluated in nine patients with AIDS. Therapy with IL-2 consisted of one subcutaneous inject
Oral health behaviour and the prevalence of oral manifestations of HIV infection in a group of HIV positive adults.: Int Dent J. 1998 Dec;48(6):557-62. Unique Identifier : AIDSLINE MED/99097964; Marcenes W; Pankhurst CL; Lewis DA; Department of Epidemiology and Public Health, University College; London, UK.; The objectives of this study were to assess the prevalence of oral manifestations of HIV infection, the periodontal health status and the oral health behaviour of a group of 51 HIV infected adults. The design was a cross-sectional descriptive study which took place in a community dental clinic in south London dedicate
Comparative study of transfer factor and acyclovir in the treatment of herpes zoster.: Int J Immunopharmacol. 1998 Oct;20(10):521-35. Unique Identifier : AIDSLINE MED/99053392; Estrada-Parra S; Nagaya A; Serrano E; Rodriguez O; Santamaria V; Ondarza R; Chavez R; Correa B; Monges A; Cabezas R; Calva C; Estrada-Garcia I; Department of Immunology, National School of Biological Sciences,; National Polytechnic Institute, Prol. Carpio Y Plan de Ayala,; Mexico, D.F. i-estrad@bios.encb.ipn.mx; Reactivation of varicella herpes virus (VHV), latent in individuals who have previously suffered varicella, gives rise to herpes zoster and in some cases leads to a sequela of post herpetic neuritis with severe pain which is refractory to analgesics. Many different antiviral agents have been tried without achieving sa
Anti-chemotactic activities of peptide-T: a possible mechanism of actions for its therapeutic effects on psoriasis.: Int J Immunopharmacol. 1998 Nov;20(11):661-7. Unique Identifier : AIDSLINE MED/99063143; Raychaudhuri SK; Raychaudhuri SP; Farber EM; Psoriasis Research Institute, Palo Alto, CA 94301, USA.; Peptide T is an octapeptide (ASTTTNYT) from the V2 region of gpl20 of HIV. D-[Ala]-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-amide (DAPTA) is one of its analogue. DAPTA has been shown to resolve the psoriatic lesions. The mechanisms of action of peptide T for its therapeutic effect is not clearly understood. Lymphomononuclear cells
Incidence and duration of hospitalizations among persons with AIDS: an event history approach.: Unique Identifier : AIDSLINE MED/99151958; Crystal S; Lo Sasso AT; Sambamoorthi U; AIDS Research Group, Institute for Health, Health Care Policy,; and Aging Research, Rutgers University, New Brunswick, NJ 08903,; USA.; OBJECTIVE: To analyze hospitalization patterns of persons with AIDS (PWAs) in a multi-state/multi-episode continuous time duration framework. DATA SOURCES: PWAs on Medicaid identified through a match between the state s AIDS Registry and Medicaid eligibility files; hospital admission and discharge dates identified thr
Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.: J Biol Chem. 1999 Feb 12;274(7):3988-93. Unique Identifier : AIDSLINE MED/99134320; Proost P; Struyf S; Schols D; Opdenakker G; Sozzani S; Allavena P; Mantovani A; Augustyns K; Bal G; Haemers A; Lambeir AM; Scharpe S; Van Damme J; De Meester I; Laboratory of Molecular Immunology, Rega Institute for Medical; Research, University of Leuven, Minderbroedersstraat 10, B-3000; Leuven, Belgium. Paul.Proost@rega.kuleuven.ac.be; The serine protease CD26/dipeptidyl-peptidase IV (CD26/DPP IV) and chemokines are known key players in immunological processes. Surprisingly, CD26/DPP IV not only removed the expected Gly1-Pro2 dipeptide from the NH2 terminus of macrophage-derived chemokine (MDC) but subsequently also the Tyr3-Gly4 dipeptide, generati
Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1).: J Biol Chem. 1999 Feb 12;274(7):4115-23. Unique Identifier : AIDSLINE MED/99134336; Kwong PD; Wyatt R; Desjardins E; Robinson J; Culp JS; Hellmig BD; Sweet RW; Sodroski J; Hendrickson WA; Department of Biochemistry and Molecular Biophysics, Columbia; University, New York, New York 10032, USA.; The extensive glycosylation and conformational mobility of gp120, the envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1), pose formidable barriers for crystallization. To surmount these difficulties, we used probability analysis to determine the most effective crystallization approach and derive equa
Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription.: J Biol Chem. 1999 Feb 12;274(7):4412-20. Unique Identifier : AIDSLINE MED/99134376; Auxilien S; Keith G; Le Grice SF; Darlix JL; LaboRetro ENS, INSERM U412, 46 allee d'Italie, 69364 Lyon cedex; 07, France.; During HIV reverse transcription, (+) strand DNA synthesis is primed by an RNase H-resistant sequence, the polypurine tract, and continues as far as a 18-nt double-stranded RNA region corresponding to the 3 end of tRNALys,3 hybridized to the viral primer binding site (PBS). Before (+) strand DNA transfer, reverse tra
A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence.: J Cell Sci. 1998 Nov;111 ( Pt 21):3129-43. Unique Identifier : AIDSLINE MED/98438559; Shirley RL; Lelivelt MJ; Schenkman LR; Dahlseid JN; Culbertson MR; Laboratories of Genetics and Molecular Biology, University of; Wisconsin, Madison, WI, USA.; In Saccharomyces cerevisiae, Upf3p is required for nonsense-mediated mRNA decay (NMD). Although localized primarily in the cytoplasm, Upf3p contains three sequence elements that resemble nuclear localization signals (NLSs) and two sequence elements that resemble nuclear export signals (NESs). We found that a cytoplasm
Quantification of human T-cell lymphotropic virus type 1 proviral load by quantitative competitive polymerase chain reaction.: J Virol Methods. 1998 Nov;75(2):123-40. Unique Identifier : AIDSLINE MED/99086135; Albrecht B; Collins ND; Newbound GC; Ratner L; Lairmore MD; Center for Retrovirus Research and Department of Veterinary; Biosciences, The Ohio State University, Columbus 43210-1092, USA.; The polymerase chain reaction (PCR) has been established as a highly sensitive technique for detection of viral DNA or RNA. However, due to inherent limitations of PCR the amount of amplified product often does not correlate with the initial amount of template DNA. This is particularly true for PCR detection of viral
Increased production of a Th2 cytokine profile by activated whole blood cells from rheumatoid arthritis patients.: J Clin Immunol. 1998 Nov;18(6):399-403. Unique Identifier : AIDSLINE MED/99074601; Haddad A; Bienvenu J; Miossec P; Department of Immunology, Hopital Edouard Herriot, France.; T cells produce regulatory cytokines which control inflammation. In rheumatoid arthritis (RA), a Th1 cytokine profile has been described in the synovium. In order to assess the Th1/Th2 cytokine balance in blood, a one step culture-immunoassay procedure was used to measure the ex vivo production of IFN gamma and IL-4 b
A randomized trial of a brief HIV risk reduction counseling intervention for women.: J Consult Clin Psychol. 1998 Oct;66(5):856-61. Unique Identifier : AIDSLINE MED/99020547; Belcher L; Kalichman S; Topping M; Smith S; Emshoff J; Norris F; Nurss J; Department of Psychology, Georgia State University, USA.; There is an urgent need for the development and implementation of effective and feasible behavioral HIV and STD interventions. The purpose of the present randomized controlled trial was to evaluate the effectiveness of a single-session, skill-based sexual risk reduction intervention for women. Participants were assess
The high prevalence of bipolar II and associated cyclothymic and hyperthymic temperaments in HIV-patients.: J Affect Disord. 1998 Sep;50(2-3):215-24. Unique Identifier : AIDSLINE MED/99073791; Perretta P; Akiskal HS; Nisita C; Lorenzetti C; Zaccagnini E; Della Santa M; Cassano GB; Department of Psychiatry, Neurobiology, Pharmacology and; Biotechnology, University of Pisa, Italy.; BACKGROUND: Although recent studies have shown high rates of current and lifetime depression in HIV-infected patients, there is little systematic data on the occurrence of bipolarity in these patients. METHOD: We compared 46 HIV patients with index major depressive episode (MDE) to an equal number of age- and sex-matc
Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity.: J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):192-9. Unique Identifier : AIDSLINE MED/99135983; Kalish RS; Askenase PW; Department of Dermatology, State University of New York at Stony; Brook Health Sciences Center 11794-8165, USA.; Delayed-type hypersensitivity (DTH) is defined as the recruitment of T cells into tissues to be activated by antigen-presenting cells to produce cytokines that mediate local inflammation. CD8+ T cells are now known to mediate DTH responses in allergic contact dermatitis, drug eruptions, asthma, and autoimmune diseases
A murine model of IgE-mediated cow's milk hypersensitivity.: J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):206-14. Unique Identifier : AIDSLINE MED/99135985; Li XM; Schofield BH; Huang CK; Kleiner GI; Sampson HA; Department of Pediatrics, Mount Sinai School of Medicine, New; York, NY 10029-6574, USA.; BACKGROUND: Cow s milk allergy (CMA) is one of the leading causes of food allergy in children. Understanding the mechanisms involved in the development of CMA has been hampered by the lack of suitable animal models. OBJECTIVE: We sought to develop a mouse model of IgE-mediated cow s milk hypersensitivity (CMH) that mi
The relevance of TH1 and TH2 cells in immediate and nonimmediate reactions to gelatin-containing vaccine [see comments]: J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):276-81. Unique Identifier : AIDSLINE MED/99135995; Ohsaki M; Tsutsumi H; Kumagai T; Yamanaka T; Wataya Y; Furukawa H; Kojima H; Saito A; Yano S; Chiba S; Department of Pediatrics, Sapporo Medical University School of; Medicine, Chuoku, Japan.; BACKGROUND: The immune mechanism of gelatin allergy, especially the participation of TH1 and TH2 cells and their cytokine secretion, has not been investigated. OBJECTIVE: We investigated the characteristics of T lymphocytes from patients allergic to gelatin-containing vaccine by secondary in vitro stimulation of circu
Signals involved in the early TH1/TH2 polarization of an immune response depending on the type of antigen.: J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):298-306. Unique Identifier : AIDSLINE MED/99135998; Bellinghausen I; Brand U; Enk AH; Knop J; Saloga J; Clinical Research Group, Department of Dermatology, University of; Mainz, Germany.; BACKGROUND: The early production of distinct cytokines by epidermal cells (ECs) in response to antigen exposure may govern the development of TH1 -like immune responses, such as contact sensitivity, or TH2 -like immune responses, such as IgE-dependent allergies of the immediate type, depending on the type of antigen.
[Treatment of CMV retinitis with intravitreal foscarnet]: J Fr Ophtalmol. 1998 Dec;21(10):723-6. Unique Identifier : AIDSLINE MED/99161196; Cochereau I; Belayachi N; Diraison C; Matheron S; Bouyer I; Hoang-Xuan T; Saimot AG; Coulaud JP; Service d'Ophtalmologie, Hopital Bichat-Claude Bernard, Paris.; PURPOSE: To assess the tolerability and efficacy of intravitreal injections of foscarnet in cytomegalovirus ( CMV ) retinitis in acquired immunodeficiency syndrome (AIDS). METHODS: Patients with CMV retinitis resistant and/or i
In situ amplification using universal energy transfer-labeled primers.: Unique Identifier : AIDSLINE MED/99150398; Nuovo GJ; Hohman RJ; Nardone GA; Nazarenko IA; We developed an amplification detection system in which a universal energy transfer-labeled primer (UniPrimer) is used in combination with any target-specific primer pair. The target specific primers each have a 5 tail sequence, which is homologous to the 3 end of the UniPrimer which, in turn, has a hairpin structur
Tuberculosis in HIV-infected persons with special emphasis on sub-Saharan Africa.: J Infect. 1998 Nov;37(3):205-9. Unique Identifier : AIDSLINE MED/99107539; Harries AD; Department of Medicine, College of Medicine, Chichiri, Blantyre,; Malawi.
Clinical presentation of HIV infection in patients aged 50 years or older.: J Infect. 1998 Nov;37(3):213-6. Unique Identifier : AIDSLINE MED/99107541; Ena J; Valls V; Lopez Aldeguer J; Garcia Gasco MP; Anon S; Navarro V; Sanchez R; Boix V; Portilla J; Roig P; Masia MM; Maestre Peiro A; Internal Medicine Division of Hospital Marina Baixa, Villajoyosa,; Alicante, Spain.; OBJECTIVES: To describe the clinical presentation of HIV disease in older patients. METHODS: In the period 1989-1996 we reviewed the medical records of 100 patients with human immunodeficiency virus (HIV) infection aged 50 years or older and, 197 controls among HIV-infected patients aged 15-40 years, who attended six
Seroprevalence of hepatitis B and C and HIV in Malawian pregnant women.: J Infect. 1998 Nov;37(3):248-51. Unique Identifier : AIDSLINE MED/99107546; Ahmed SD; Cuevas LE; Brabin BJ; Kazembe P; Broadhead R; Verhoeff FH; Hart CA; Liverpool School of Tropical Medicine, UK.; OBJECTIVES: to describe the seroprevalence of hepatitis B (HBV) and C (HCV) infection in HIV-positive and HIV-negative pregnant women from rural Malawi . METHODS: descriptive study using serum samples collected between 1993-1995 in the Shire valley in rural Malawi. Fifty HIV-positiv
Mycobacterium kansasii and human immunodeficiency virus co-infection in London.: J Infect. 1998 Nov;37(3):252-9. Unique Identifier : AIDSLINE MED/99107547; Klein JL; Corbett EL; Slade PM; Miller RF; Coker RJ; Department of Genitourinary Medicine, St. Mary's Hospital,; London, UK.; OBJECTIVES: although Mycobacterium kansasii infection has long been endemic in the U.K., the disease burden and characteristics of infection in the HIV-seropositive population has not been well documented. This study addresses these issues in an inner city population that comprises a quarter of all cases of acquired i
Protein levels of interleukin-12 p70 holomer, its p40 chain and interferon-gamma during advancing HIV infection.: J Infect. 1998 Nov;37(3):282-6. Unique Identifier : AIDSLINE MED/99107551; Rockstroh JK; Kreuzer KA; Sauerbruch T; Spengler U; Department of Medicine, University of Bonn, Germany.; BACKGROUND: a switch from T helper 1 (TH1) to T helper 2 (TH2)-like cytokine production has been proposed for progressive HIV infection. OBJECTIVE: to study whether this hypothesis is reflected by altered IL-12 and IFN-gamma serum levels in HIV patients. METHODS: we measured serum levels of IL-12 p40 and p70 and IFN-g
Disseminated histoplasmosis in an infant with acquired immunodeficiency syndrome.: J Infect. 1998 Nov;37(3):298-301. Unique Identifier : AIDSLINE MED/99107556; Wang H; Abrahams C; Hart J; Johnson D; Wollmann RL; Department of Pathology, The University of Chicago Hospitals, IL; 60637, USA.; Disseminated histoplasmosis has been recognized as a serious opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). However, cases reported in the literature have been predominantly in adult patients. Here we report an infant with AIDS who presented with fever, cough, rhinorrhea, hepatospl
[Autoimmune diseases and retroviruses]: Nippon Naika Gakkai Zasshi. 1998 Oct 10;87(10):2093-9. Unique Identifier : AIDSLINE MED/99084255; Sugaya T; Yoshiki T
Helper T cell determinant peptide contributes to induction of cellular immune responses by peptide vaccines against hepatitis C virus.: J Gen Virol. 1999 Jan;80 ( Pt 1):187-93. Unique Identifier : AIDSLINE MED/99131400; Hiranuma K; Tamaki S; Nishimura Y; Kusuki S; Isogawa M; Kim G; Kaito M; Kuribayashi K; Adachi Y; Yasutomi Y; Department of Bioregulation, Mie University School of Medicine,; Tsu, Japan.; The capacity of novel subunit vaccines to generate cytotoxic T lymphocytes (CTLs) against hepatitis C virus (HCV) was assessed. BALB/c mice were immunized with peptides based on the CTL and helper T cell (Th) epitopes of the HCV core, with a mixture of CTL and Th peptides (CTL+Th) or with a conjugated Th-CTL peptide.
Role of class I major histocompatibility complex-restricted and unrestricted suppression of human immunodeficiency virus type 1 replication by CD8+ T lymphocytes.: J Gen Virol. 1999 Jan;80 ( Pt 1):209-16. Unique Identifier : AIDSLINE MED/99131403; Ohashi T; Kubo M; Kato H; Iwamoto A; Takahashi H; Fujii M; Kannagi M; Department of Immunotherapeutics, Tokyo Medical and Dental; University, Japan.; CD8+ T lymphocytes of asymptomatic human immunodeficiency virus type 1 (HIV-1) carriers (ACs) are capable of suppressing HIV-1 replication in CD4+ peripheral blood mononuclear cells (PBMC) by a variety of known and unknown mechanisms. In the present study, cell contact-dependent, major histocompatibility complex type
A human immunodeficiency virus type 1 Env-granulocyte-macrophage colony-stimulating factor fusion protein enhances the cellular immune response to Env in a vaccinia virus-based vaccine.: J Gen Virol. 1999 Jan;80 ( Pt 1):217-23. Unique Identifier : AIDSLINE MED/99131404; Rodriguez D; Rodriguez JR; Llorente M; Vazquez I; Lucas P; Esteban M; Martinez-A C; del Real G; Department of Molecular & Cellular Biology, Centro Nacional de; Biotecnologia, CSIC/UAM, Madrid, Spain.; Vaccinia virus (VV) infection induces protective T- and B-cell responses, making recombinants based on VV good candidates for the development of effective vaccines to other viruses. VV recombinants expressing the human immunodeficiency virus (HIV) envelope protein (Env) have been generated in several laboratories and
Properties and mechanism of action of a 17 amino acid, V3 loop-specific microantibody that binds to and neutralizes human immunodeficiency virus type 1 virions.: J Gen Virol. 1999 Jan;80 ( Pt 1):225-36. Unique Identifier : AIDSLINE MED/99131405; Jackson NA; Levi M; Wahren B; Dimmock NJ; Department of Biological Sciences, University of Warwick,; Coventry, UK.; Only two virus-neutralizing peptide microantibodies (MicroAbs) have been described and little is known about their mode of action. This report concerns a 17 amino acid cyclized MicroAb, derived from the third complementarity-determining region of the heavy chain of MAb F58 (IgG1), that recognizes the same minimum epit
The antibody response of cattle infected with bovine immunodeficiency virus to peptides of the viral transmembrane protein.: J Gen Virol. 1999 Jan;80 ( Pt 1):237-43. Unique Identifier : AIDSLINE MED/99131406; Scobie L; Venables C; Hughes K; Dawson M; Jarrett O; Department of Veterinary Pathology, University of Glasgow,; Bearsden, UK. l.scobie@vet.gla.ac.uk; The development of the antibody response to peptides of the transmembrane glycoprotein of bovine immunodeficiency virus (BIV) was followed over a period of 50 weeks in six cattle experimentally infected with the BIV(FL112) isolate. Antibody was detected by an enzyme immunoassay using either a linear or a cyclized pept
Comparative sequence analysis and predictions for the envelope glycoproteins of foamy viruses.: J Gen Virol. 1999 Jan;80 ( Pt 1):245-54. Unique Identifier : AIDSLINE SWISSPROT; Wang G; Mulligan MJ; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.; The foamy viruses (FVs) are a genus of complex retroviruses that has recently been found to possess several novel molecular features. There is increasing interest in the development of FVs as novel vectors for gene delivery. As there are remarkably few published studies of FV proteins, these recent findings prompted u
Novel endogenous retroviral sequences in the chicken genome closely related to HPRS-103 (subgroup J) avian leukosis virus.: J Gen Virol. 1999 Jan;80 ( Pt 1):261-8. Unique Identifier : AIDSLINE GENBANK/AJ222690; Smith LM; Toye AA; Howes K; Bumstead N; Payne LN; Venugopal K; Institute for Animal Health, Newbury, Berkshire, UK.; HPRS-103, the prototype of avian leukosis virus (ALV) subgroup J, is a recently identified retrovirus associated with myeloid leukosis in meat-type chickens. Although this virus shows high sequence identity to other ALV subgroups within the gag and pol genes, its env gene is highly diverged (with only about 40% sequen
Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells.: J Gen Virol. 1999 Jan;80 ( Pt 1):83-90. Unique Identifier : AIDSLINE MED/99131387; Yu Y; Black JB; Goldsmith CS; Browning PJ; Bhalla K; Offermann MK; Winship Cancer Center, Emory University, Atlanta, GA 30322, USA.; Human herpesvirus-8 (HHV-8) is a gammaherpesvirus that is present primarily in a state of low level persistence in primary effusion lymphoma cell lines. Using BCBL-1 cells that harbour HHV-8 but lack Epstein-Barr virus, we demonstrate that sodium butyrate is much more effective than the phorbol ester 12-O-tetradecanoy
Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii.: J Nat Prod. 1999 Jan;62(1):130-2. Unique Identifier : AIDSLINE MED/99115755; Fuller RW; Blunt JW; Boswell JL; Cardellina JH 2nd; Boyd MR; Developmental Therapeutics Program, Division of Cancer Treatment; and Diagnosis, National Cancer Institute-Frederick Cancer; Research and Development Center, Building 1052, Room 121,; Frederick, MD 21702-1201, USA.; The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F (1). The structure was solved by extensive NMR analyses and by acid-catalyzed conversion to 30-epi-cambogin
Vismiaphenones D-G, new prenylated benzophenones from Vismia cayennensis.: J Nat Prod. 1999 Jan;62(1):67-9. Unique Identifier : AIDSLINE MED/99115740; Fuller RW; Westergaard CK; Collins JW; Cardellina JH 2nd; Boyd MR; Laboratory of Drug Discovery Research and Development,; Developmental Therapeutics Program, Division of Cancer Treatment; and Diagnosis, National Cancer Institute, NCI-FCRDC, Bldg. 1052,; Room 121, Frederick, Maryland 21702-1201, USA.; Following anti-HIV bioassay-guided fractionation, four new prenylated benzophenones, vismiaphenones D-G (7-10), were isolated from extracts of leaves of Vismia cayennensis. The structures were elucidated by spectral analyses. Only vismiaphenone D (7) exhibited HIV-inhibitory activity in the NCI primary screen.
Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba.: J Nat Prod. 1999 Jan;62(1):94-7. Unique Identifier : AIDSLINE MED/99115746; Chen DF; Zhang SX; Wang HK; Zhang SY; Sun QZ; Cosentino LM; Lee KH; Department of Pharmacognosy, School of Pharmacy, Shanghai Medical; University, Shanghai 200032, People's Republic of China.; dfchen@shmu.edu.cn; Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an
Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution.: J Nucl Med. 1999 Feb;40(2):268-76. Unique Identifier : AIDSLINE MED/99148701; Carrasquillo JA; White JD; Paik CH; Raubitschek A; Le N; Rotman M; Brechbiel MW; Gansow OA; Top LE; Perentesis P; Reynolds JC; Nelson DL; Waldmann TA; Department of Nuclear Medicine, Warren G. Magnuson Clinical; Center, National Cancer Institute, National Institutes of Health,; Bethesda, Maryland, USA.; Monoclonal antibodies (MoAb) labeled with 90Y are being used for radioimmunotherapy. Because 90Y is a beta emitter, quantitative information from imaging is suboptimal. With the concept of a matched pair of isotopes, 111In is used as a surrogate markerfor90Y. We evaluated the differences in biodistribution between 1
Oral lesions in children with perinatally acquired human immunodeficiency virus infection.: J Oral Pathol Med. 1999 Feb;28(2):49-53. Unique Identifier : AIDSLINE MED/99133748; Nicolatou O; Theodoridou M; Mostrou G; Velegraki A; Legakis NJ; Department of Oral Pathology and Surgery, School of Dentistry,; University of Athens, Greece.; Fifteen vertically HIV-infected children aged between 2 and 12 years were followed up for 1 year, weekly to monthly, to study the incidence of oral lesions. At the time of first examination, oral candidiasis (OC) was observed in nine children. Seven children presented with the erythematous type only and two with pseud
Structural biology of HIV.: J Mol Biol. 1999 Jan 8;285(1):1-32. Unique Identifier : AIDSLINE MED/99096900; Turner BG; Summers MF; Howard Hughes Medical Institute, Department of Chemistry,; University of Maryland Baltimore County, 1000 Hilltop Circle,; Baltimore, MD, 21250, USA.; The human immunodeficiency virus (HIV) genome encodes a total of three structural proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the past ten years have provided high-resolution three-dimensional structural information for all of the viral enzymes, structural proteins and enve
Stabilization of the anticodon stem-loop of tRNALys,3 by an A+-C base-pair and by pseudouridine.: J Mol Biol. 1999 Jan 8;285(1):115-31. Unique Identifier : AIDSLINE PDB/1BZ7; Durant PC; Davis DR; University of Utah, Salt Lake City, UT, 84112, USA.; NMR spectroscopy was used to determine the solution structures of RNA oligonucleotides comprising the anticodon domain of tRNALys,3. The structural effects of the pseudouridine modification at position 39 were investigated and are well correlated with changes in thermodynamic parameters derived from temperature depend
Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.: J Mol Biol. 1999 Jan 8;285(1):333-45. Unique Identifier : AIDSLINE PDB/1BH4; Daly NL; Koltay A; Gustafson KR; Boyd MR; Casas-Finet JR; Craik DJ; Centre for Drug Design and Development, University of Queensland,; Brisbane, Queensland, 4072, Australia.; The three-dimensional solution structure of circulin A, a 30 residue polypeptide from the African plant Chassalia parvifolia, has been determined using two-dimensional 1H-NMR spectroscopy. Circulin A was originally identified based upon its inhibition of the cytopathic effects and replication of the human immunodefici
Cross-strand purine-pyrimidine stack and sheared purine.pyrimidine pairing in the human HIV-1 reverse transcriptase inhibitors.: J Mol Biol. 1999 Jan 8;285(1):41-8. Unique Identifier : AIDSLINE MED/99096902; Chou SH; Tseng YY; Institute of Biochemistry, National Chung-Hsing Univesity,; Taichung 40227 Taiwan. shchou@dragon.nchu.edu.tw; Cross-strand homo purine-purine (G-G or A-A) stacks and sheared purine.purine pairing have been found to be important motifs in nucleic acid duplex structures. We now report novel cross-strand purine-pyrimidine (A-C) and hetero purine-purine (G-A) stacks that are established from a sheared purine.pyrimidine (A.C) pair
Exploring three-dimensional structures of the HIV-1 RNA/tRNALys3 initiation complex.: J Mol Biol. 1999 Jan 15;285(2):449-53. Unique Identifier : AIDSLINE MED/99096936; Elgavish T; VanLoock MS; Harvey SC; Department of Biochemistry and Molecular Genetics, University of; Alabama at Birmingham, Birmingham, AL, 35294, USA.; Human immunodeficiency virus type 1 (HIV-1) uses host tRNA as a primer for reverse transcription of its viral RNA. The 3 terminal 18 nucleotides of human tRNALys3 are complementary to the primer binding site on the viral RNA. A secondary structure model for the HIV-1 RNA/tRNALys3 initiation complex has been proposed
Residential detoxification for substance abusers with HIV/AIDS. Walden House Detoxification Program.: J Subst Abuse Treat. 1999 Jan;16(1):87-95. Unique Identifier : AIDSLINE MED/99105073; Sargent R; Sorensen JL; Greenberg B; Evans G; Acampora AP; Department of Psychiatry, UCSF at San Francisco General Hospital; 94110, USA. james@itsa.ucsf.edu; Substance abusers with HIV/AIDS have a complex array of problems that are not easily addressed in outpatient or long-term residential programs. A new but promising treatment modality is residential detoxification for substance abusers with HIV/AIDS, such as described by this paper. The purpose of the program is profil
From the Centers for Disease Control and Prevention. HIV testing--United States, 1996.: JAMA. 1999 Feb 24;281(8):697-8. Unique Identifier : AIDSLINE MED/99159795
Use of antiretroviral therapy by intravenous drug users with HIV [letter]: JAMA. 1999 Feb 24;281(8):699; discussion 700-1. Unique Identifier : AIDSLINE MED/99159796; Anderson JF
Use of antiretroviral therapy by intravenous drug users with HIV [letter]: JAMA. 1999 Feb 24;281(8):699; discussion 700-1. Unique Identifier : AIDSLINE MED/99159797; Mannheimer SB; Curtis JL; El-Sadr WM
Use of antiretroviral therapy by intravenous drug users with HIV [letter]: JAMA. 1999 Feb 24;281(8):699-700; discussion 700-1. Unique Identifier : AIDSLINE MED/99159798; Michaels SH; Clark R; Kissinger P
Use of antiretroviral therapy by intravenous drug users with HIV [letter]: JAMA. 1999 Feb 24;281(8):700-1. Unique Identifier : AIDSLINE MED/99159799; Murri R; Ammassari A; De Luca A; Cingolani A; Antinori A; Ortona L
An asymptomatic 41-year-old man with HIV infection [clinical conference]: JAMA. 1999 Feb 24;281(8):739-44. Unique Identifier : AIDSLINE MED/99159810; Makadon HJ; Beth Israel Deaconess Medical Center, Harvard Medical School,; Boston, Mass 02215, USA.
Disability discrimination in America: HIV/AIDS and other health conditions.: JAMA. 1999 Feb 24;281(8):745-52. Unique Identifier : AIDSLINE MED/99159812; Gostin LO; Feldblum C; Webber DW; Georgetown University Law Center, Washington, DC 20001-2075, USA.; gostin@law.georgetown.edu; The Americans With Disabilities Act (ADA) was widely hailed at the time of its enactment in 1990 as providing broad protection against disability discrimination, including discrimination against individuals infected with the human immunodeficiency virus (HIV). In the years since its enactment, however, courts frequent
A positive response to perinatal HIV [editorial]: Lancet. 1999 Feb 13;353(9152):511. Unique Identifier : AIDSLINE MED/99151430
Preventing HIV infection: lessons from Mwanza and Rakai [comment]: Lancet. 1999 Feb 13;353(9152):513-5. Unique Identifier : AIDSLINE MED/99151432; Hitchcock P; Fransen L; Sexually Transmitted Diseases Branch, National Institute of; Allergy and Infectious Disease, Bethesda, MD 20892, USA.
Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Rakai Project Study Group [see comments]: Lancet. 1999 Feb 13;353(9152):525-35. Unique Identifier : AIDSLINE MED/99151438; Wawer MJ; Sewankambo NK; Serwadda D; Quinn TC; Paxton LA; Kiwanuka N; Wabwire-Mangen F; Li C; Lutalo T; Nalugoda F; Gaydos CA; Moulton LH; Meehan MO; Ahmed S; Gray RH; Centre for Population and Family Health, Columbia University; School of Public Health, New York 10032, USA.; BACKGROUND: The study tested the hypothesis that community-level control of sexually transmitted disease (STD) would result in lower incidence of HIV-1 infection in comparison with control communities. METHODS: This randomised, controlled, single-masked, community-based trial of intensive STD control, via home-based m
Progress in HIV-1 therapy continues on upward track [news]: Lancet. 1999 Feb 13;353(9152):565. Unique Identifier : AIDSLINE MED/99151454; Montaner J; Mellors J
Sex differences in HIV-1 viral load and progression to AIDS. Swiss HIV Cohort Study [letter]: Lancet. 1999 Feb 13;353(9152):589; discussion 590-1. Unique Identifier : AIDSLINE MED/99151462; Junghans C; Ledergerber B; Chan P; Weber R; Egger M
Sex differences in HIV-1 viral load and progression to AIDS. ICONA Study Group. Italian cohort of HIV-1 positive individuals [letter]: Lancet. 1999 Feb 13;353(9152):589-90; discussion 590-1. Unique Identifier : AIDSLINE MED/99151463; Moroni M
Sex differences in HIV-1 viral load and progression to AIDS [letter]: Lancet. 1999 Feb 13;353(9152):590-1. Unique Identifier : AIDSLINE MED/99151464; Foulkes MA; Deyton L
Fatal MDMA intoxication [letter]: Lancet. 1999 Feb 13;353(9152):593. Unique Identifier : AIDSLINE MED/99151468; de la Torre R; Ortuno J; Mas M; Farre M; Segura J
Fatal MDMA intoxication [letter]: Lancet. 1999 Feb 13;353(9152):593-4. Unique Identifier : AIDSLINE MED/99151469; Schwab M; Seyringer E; Brauer RB; Hellinger A; Griese EU
Former French ministers on trial for infected blood-products scandal [news]: Lancet. 1999 Feb 20;353(9153):653. Unique Identifier : AIDSLINE MED/99153415; de Bousingen DD
South African faces an AIDS crisis as government health campaigns fail [news]: Lancet. 1999 Feb 20;353(9153):653. Unique Identifier : AIDSLINE MED/99153416; Baleta A
Due process or French farce? [editorial]: Nature. 1999 Feb 18;397(6720):545. Unique Identifier : AIDSLINE MED/99158117
Scientists defend French ex-ministers in blood trial [news]: Nature. 1999 Feb 18;397(6720):548. Unique Identifier : AIDSLINE MED/99158121; Butler D
US launches trial of AIDS vaccine in Uganda [news]: Nature. 1999 Feb 18;397(6720):554. Unique Identifier : AIDSLINE MED/99158129
[A changed pattern of opportunistic infections and malignancies in HIV-seropositive patients after the introduction of intensive anti-HIV-combination therapy]: Ned Tijdschr Geneeskd. 1998 Oct 31;142(44):2395-9. Unique Identifier : AIDSLINE MED/99082053; Borleffs JC; Schneider MM; Hoepelman IM; Academisch Ziekenhuis, Afd. Interne Geneeskunde, Utrecht.; The application of potent combinations of antiretroviral drugs ( highly active antiretroviral therapy (HAART)) makes effective therapy of HIV infection feasible. Consequently, the pattern of opportunistic infections and other secondary complications has changed. The incidence of infections and mortality due to aids h
[Intracranial and orbital extension of a nasal cavity adult T-cell leukemia: a case report]: No Shinkei Geka. 1999 Jan;27(1):55-9. Unique Identifier : AIDSLINE MED/99149124; Hayashi K; Anda T; Yasunaga A; Shibata S; Sadamori N; Kisikawa M; Tsuda N; Department of Neurosurgery, Juzenkai Hospital, Nagasaki-shi,; Japan.; Adult T-cell leukemia (ATL) is one kind of leukemia induced by human T lymphotropic virus type I (HTLV-I) infection. An unusual case of ATL is presented. A fifty-one-year-old male patient was admitted to our hospital because of nasal obstruction and blindness in the left eye. Imaging study revealed a mass lesion in th
Implications of HIV and hepatitis C coinfection [news]: Nurse Pract. 1998 Dec;23(12):78, 81. Unique Identifier : AIDSLINE MED/99095130; Klaus BD; Grodesky MJ
Atypical mycobacterial pulmonary disease and bronchial obstruction in HIV-negative children.: Pediatr Pulmonol. 1998 Dec;26(6):380-8. Unique Identifier : AIDSLINE MED/99103287; Dore ND; LeSouef PN; Masters B; Francis PW; Cooper DM; Wildhaber JH; Fall AJ; Sly PD; Department of Respiratory Medicine, Royal Children's Hospital,; Brisbane, Queensland, Australia.; Atypical mycobacterial infection in HIV-negative children usually presents with cervical lymphadenopathy. We report on 10 children who are HIV-negative and who presented with pulmonary disease, in whom either culture-proven atypical mycobacterium infection (four), positive avian Mantoux test (five), or lack of respons
The untouchables.: Nurs Times. 1999 Jan 13-19;95(2):12-4. Unique Identifier : AIDSLINE MED/99166558; Coombes R
A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations.: Protein Eng. 1998 Nov;11(11):999-1005. Unique Identifier : AIDSLINE MED/99092747; Wallqvist A; Smythers GW; Covell DG; Frederick Cancer Research and Development Center, National Cancer; Institute, Science Applications International Corporation, MD; 21702, USA.; We investigated the HIV-1 protease molecule for the occurrence of cooperative folding units, i.e. structural units that exhibit a relatively stronger protection against unfolding than do other parts of the molecule. Calculated unfolding penalties are used to delineate folding units. This procedure identifies a folding
T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.: Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1024-9. Unique Identifier : AIDSLINE MED/99128356; Yamashita M; Kimura M; Kubo M; Shimizu C; Tada T; Perlmutter RM; Nakayama T; Department of Developmental Immunology, Chiba University School; of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba; 260-8670, Japan.; The central role of type-2 helper T (Th2) cells in the development of allergic responses and immune responses against helminthic parasites is well documented. The differentiation of Th2 cells from naive T cells requires both the recognition of antigen by T cell antigen receptors (TCR) and the activation of downstream
Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.: Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1030-5. Unique Identifier : AIDSLINE MED/99128357; Stranford SA; Skurnick J; Louria D; Osmond D; Chang SY; Sninsky J; Ferrari G; Weinhold K; Lindquist C; Levy JA; Departments of Medicine, University of California, San Francisco,; CA 94143-1270, USA.; Individuals repeatedly exposed to HIV, but who remain uninfected, form a population enriched for persons likely to have either natural or acquired resistance to the virus. We have studied four such exposed uninfected cohorts, representing 60 individuals, for evidence of protective immunity. This population included pa
Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase.: Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):835-9. Unique Identifier : AIDSLINE MED/99128323; Gladyshev VN; Stadtman TC; Hatfield DL; Jeang KT; Department of Biochemistry, University of Nebraska, Lincoln, NE; 68588-0664, USA. vng@unlinfo2.unl.edu; It has been observed previously that plasma selenium and glutathione levels are subnormal in HIV-infected individuals, and plasma glutathione peroxidase activity is decreased. Under these conditions the survival rate of AIDS patients is reduced significantly. In the present study, using 75Se-labeled human Jurkat T cel
HIV infection and AIDS.: Prim Care. 1998 Dec;25(4):759-74. Unique Identifier : AIDSLINE MED/98406297; Shearer WT; Department of Pediatrics, Baylor College of Medicine, Houston,; Texas.; The entry of one HIV virion into a human being has the potential to cause death by the inexorable replication of the virus within the principal T lymphocyte, the CD4+ T cell. Although combination antiretroviral therapy, particularly therapy with protease inhibitors ,
[Rapid diagnosis and susceptibility of Mycobacterium tuberculosis to antibiotics using MGIT system]: Rev Argent Microbiol. 1998 Oct-Dec;30(4):155-62. Unique Identifier : AIDSLINE MED/99135195; Morcillo N; Scipioni S; Vignoles M; Trovero A; Hospital Dr. Antonio A. Cetrangolo, Pcia. de Buenos Aires,; Argentina.; New technologies for rapid detection and drug susceptibility testing of mycobacteria are needed in clinical laboratories in order to attempt a rapid diagnosis and effective treatment of tuberculosis (TB) specially of cases resistant to isoniazid (H) and rifampin (RMP) (MDR-TB). A total of 218 pulmonary specimens from
[Disseminated cutaneous sporotrichosis as the initial manifestation of acquired immunodeficiency syndrome--case report]: Rev Soc Bras Med Trop. 1999 Jan-Feb;32(1):57-61. Unique Identifier : AIDSLINE MED/99126788; Neto R da J; Machado AA; de Castro G; Quaglio AS; Martinez R; Departamento de Clinica Medica da Faculdade de Medicina de; Ribeirao Preto da Universidade de Sao Paulo, Brasil.; The authors report a case of disseminated cutaneous infection with Sporothrix schenckii in a previously asymptomatic HIV-infected 30 year-old man. Extensive cutaneous involvement was observed with suppurative collections and ulcerations. The agent was isolated in culture. Treatment with liposomal amphotericin B proved
[The use of HIV-1 protease inhibitors. Their effects on AIDS-correlated outpatient and hospitalization activities. A catchment area study]: Recenti Prog Med. 1998 Dec;89(12):623-4. Unique Identifier : AIDSLINE MED/99136458; Resta F; Buccoliero G; Moscogiuri R; Chimienti A; Cristiano L; Lonero G; Angelini P; Divisione di Malattie Infettive, Azienda Ospedaliera SS; Annunziata, Taranto.; OBJECTIVE: To evaluate the effects of the use of protease inhibitors (IP) on the out-patient department s activities and hospitalizations of HIV-1 infected subjects. METHODS: From the December 1996 IP was available in our hospital, so the years 1996 and 1997 were st
[Systemic Salmonella arizonae infections in patients with a deficiency of cell-mediated immunity. A report of 2 cases and a review of the literature]: Recenti Prog Med. 1998 Dec;89(12):632-6. Unique Identifier : AIDSLINE MED/99136461; Carfagna P; Brandimarte C; Bianco G; Galie M; Paris A; Venditti M; Dipartimento di Medicina Clinica, Universita La Sapienza, Roma.; Systemic infections induced by Salmonella arizonae have been described in patients with underlying cell-mediated immunodeficiencies, usually resident in southern countries of U.S. and in Mexico . This peculiar geographic distribution is probably due to the ingestion of meat or drugs
[Metabolic disorders due to HIV-1 protease inhibitors (editorial)]: Recenti Prog Med. 1998 Dec;89(12):652-3. Unique Identifier : AIDSLINE MED/99136466; Liguori M; Urso R; Croce GF
[AIDS and opportunistic visceral mycoses. A diagnostic and therapeutic update]: Recenti Prog Med. 1998 Dec;89(12):657-67. Unique Identifier : AIDSLINE MED/99136468; Manfredi R; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita, Bologna.; Candidiasis, cryptococcosis, aspergillosis, histoplasmosis, and coccidioidomycosis are the most commonly recognized visceral mycoses complicating the course of HIV infection and AIDS. Their current management issues are discussed on the ground of the personal experie
[A new type of HIV (news)]: Recenti Prog Med. 1998 Dec;89(12):686. Unique Identifier : AIDSLINE MED/99136472; De Giuseppe R
[The anti-HIV action of chicoric acid (news)]: Recenti Prog Med. 1998 Dec;89(12):686. Unique Identifier : AIDSLINE MED/99136473; De Giuseppe R
[A new anti-HIV drug (news)]: Recenti Prog Med. 1998 Dec;89(12):687. Unique Identifier : AIDSLINE MED/99136474; De Giuseppe R
[Antibodies against Toxoplasma gondii in patients with HIV in Yucatan]: Rev Invest Clin. 1998 Sep-Oct;50(5):419-22. Unique Identifier : AIDSLINE MED/99134832; Gongora-Biachi RA; Gonzalez-Martinez P; Castro-Sansores C; Alvarez-Moguel R; Pavia-Ruz N; Lara-Perera D; Alonzo-Salomon G; Palacios-Perez E; Lab. de Hematologia del Centro de Investigaciones Regionales Dr.; Hideyo Noguchi, Universidad Autonoma de Yucatan, Mexico.; gbiachi@tunku.uady.mx; OBJECTIVE: To determine the prevalence of antibodies type IgG to T. gondii in patients with HIV infection type 1 in the Yucatan peninsula. METHODS: 95 patients with HIV and 100 blood donors as controls were studied. The search for IgG antibodies to T. gondii was done with a third generation solid-phase enzyme immunoas
[Testicular lymphoma in two patients with AIDS and two without AIDS]: Rev Invest Clin. 1998 Sep-Oct;50(5):423-7. Unique Identifier : AIDSLINE MED/99134833; Perez-Santos LG; Gamboa-Dominguez A; Guzman-Rodriguez H; Salazar-Nando A; Tapia-Rangel B; Sotomayor-de-Zavaleta M; Gabilondo-Navarro F; Instituto Nacional de la Nutricion Salvador Zubiran, Mexico,; D.F., Mexico.; OBJECTIVE: To describe the clinical, morphological and inmunophenotypic characteristics and followup of testicular non Hodgkin lymphomas seen in a referral center. METHODS: We reviewed the cases of testicular lymphoma seen from 1987 to 1997. We obtained data of laboratory tests, radiological findings, clinical course,
Pneumocystis carinii: a historical perspective.: Semin Respir Infect. 1998 Dec;13(4):279-82. Unique Identifier : AIDSLINE MED/99087658; Walzer PD; Cincinnati VA Medical Center, University of Cincinnati College of; Medicine, OH 45220, USA.; The emergence of Pneumocystis carinii pneumonia is traced from its origins as an obscure pulmonary pathogen to its place as a prominent cause of lung infection in patients who have acquired immune deficiency syndrome. Improvements in diagnosis and treatment have resulted in better care of patients with this infection.
Pneumocystis pneumonia: clinical presentation and diagnosis in patients with and without acquired immune deficiency syndrome.: Semin Respir Infect. 1998 Dec;13(4):289-95. Unique Identifier : AIDSLINE MED/99087660; Thomas CF Jr; Limper AH; Department of Biochemistry and Molecular Biology, Mayo Clinic,; Rochester, MN, USA.; Pneumocystis carinii causes severe pneumonia in immunocompromised hosts. Although this most commonly occurs in patients with the acquired immunodeficiency syndrome (AIDS), other groups of immunocompromised patients without AIDS are also at risk for P. carinii pneumonia. These patients have solid or hematologic maligna
Treatment and prophylaxis of Pneumocystis carinii pneumonia.: Semin Respir Infect. 1998 Dec;13(4):296-303. Unique Identifier : AIDSLINE MED/99087661; Castro M; Department of Internal Medicine, Washington University School of; Medicine, St Louis, MO 63110-1093, USA.; Early effective management of Pneumocystis carinii pneumonia improves outcome in patients with this disorder. Trimethoprim-sulfamethoxazole remains the agent of choice for treatment of severe P. carinii pneumonia. Pentamidine, trimethoprim-dapsone, atovaquone, and other regimens are useful in selected clinical situati
Lymphocytes in host defense against Pneumocystis carinii.: Unique Identifier : AIDSLINE MED/99087665; Beck JM; Harmsen AG; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48105-2300, USA.; Host defense against Pneumocystis carinii depends on complex interactions between host immune cells and mediators. In immunocompetent hosts, the immune system provides efficient and effective defense against P. carinii. Clinical and experimental investigations confirm that lymphocytes control and coordinate this defen
The neuropathology of adult HIV infection.: Rev Neurol (Paris). 1998 Dec;154(12):816-29. Unique Identifier : AIDSLINE MED/99131095; Bell JE; Department of Pathology, Western General Hospital, Edinburgh,; United Kingdom.; Since the onset of the acquired immune deficiency syndrome (AIDS) epidemic fifteen years ago, much has been learned about the effects of the human immunodeficiency virus (HIV) in the nervous system. This review summarizes the pathology findings in the central nervous system (CNS). There is now abundant evidence that H
[Pathophysiology of HIV-1 infection of the nervous system and AIDS- related dementia]: Rev Neurol (Paris). 1998 Dec;154(12):830-42. Unique Identifier : AIDSLINE MED/99131096; Seilhean D; Michaud J; Duyckaerts C; Hauw JJ; Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la; Salpetriere, Paris, France.
[Cognitive disorders in AIDS: clinical, virological and neuroradiological features]: Rev Neurol (Paris). 1998 Dec;154(12):843-9. Unique Identifier : AIDSLINE MED/99131097; Stankoff B; Suarez S; Rosemblum O; Conquy L; Turell E; Bricaire F; Coutellier A; Calvez V; Lacomblez L; Tourbah A; Lubetzki C; Federation de Neurologie, Hopital de la Salpetriere, Paris.; HIV-associated neurocognitive disorders are mainly reported during the late stages of the disease, in deeply immunosuppressed patients Clinically, they present as a subcortical cognitive impairment, dominated by reduced psychomotor speed and memory deficit. Encephalic magnetic resonance imaging shows in most cases a d
[Neurological complications of HIV-1 infection in an infant born to a seropositive mother]: Rev Neurol (Paris). 1998 Dec;154(12):850-5. Unique Identifier : AIDSLINE MED/99131098; Tardieu M; Departement de Pediatrie et Laboratoire, Hopital Bicetre, Le; Kremlin.
French AIDS research pioneers to testify in trial of ministers [news]: Science. 1999 Feb 12;283(5404):910-1. Unique Identifier : AIDSLINE MED/99170056; Balter M
Cheap treatment cuts HIV transmission [news]: Science. 1999 Feb 12;283(5404):916-7. Unique Identifier : AIDSLINE MED/99170060; Cohen J
Researchers urged not to inject virulent HIV strain into chimps [news; comment]: Science. 1999 Feb 19;283(5405):1090-1. Unique Identifier : AIDSLINE MED/99173145; Cohen J
Virulent HIV strains, chimpanzees, and trial vaccines [letter] [see comments]: Science. 1999 Feb 19;283(5405):1117-8. Unique Identifier : AIDSLINE MED/99173154; Prince AM; Allan J; Andrus L; Brotman B; Eichber J; Fouts R; Goodall J; Marx P; Murthy KK; McGreal S; Noon C
T cells and dendritic cells get intimate [comment]: Science. 1999 Feb 19;283(5405):1124-5. Unique Identifier : AIDSLINE MED/99173156; Bottomly K; Department of Immunobiology, Yale University School of Medicine,; New Haven, CT 06520, USA. kim.bottomly@yale.edu
Reciprocal control of T helper cell and dendritic cell differentiation [see comments]: Science. 1999 Feb 19;283(5405):1183-6. Unique Identifier : AIDSLINE MED/99148107; Rissoan MC; Soumelis V; Kadowaki N; Grouard G; Briere F; de Waal Malefyt R; Liu YJ; Schering-Plough, Laboratory for Immunological Research, 27 chemin; des Peupliers, Boite Postale 11, 69571, Dardilly, France.; It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+C
[First case in Russia of coinfection of visceral leishmaniasis and HIV-infection]: Ter Arkh. 1998;70(11):31-3. Unique Identifier : AIDSLINE MED/99134613; Konstantinova TN; Lysenko AIa; Lavdovskaia MV; Imamkuliev KD; Sel'kova EP; Anchukova EL; Ageenko TA
Swapping for life.: Tex Med. 1999 Feb;95(2):52-5. Unique Identifier : AIDSLINE MED/99149320; Moran T
Immunoregulatory role of CD8alpha in the veto effect.: Transplantation. 1999 Feb 15;67(3):372-80. Unique Identifier : AIDSLINE MED/99153352; Asiedu C; Meng Y; Wang W; Huang Z; Contreras JL; George JF; Thomas JM; Department of Surgery, University of Alabama at Birmingham,; 35294, USA.; BACKGROUND: Allogeneic bone marrow cell (allo-BMC) infusion induces tolerance to incompatible renal allografts in rhesus macaques after depletion of peripheral T lymphocytes with cytolytic anti-T cell antibodies. The tolerogenic effect of allo-BMC, ascribed to a veto mechanism, associates with specific functional dele
CD4+ cells play a major role in xenogeneic human anti-pig cytotoxicity through the Fas/Fas ligand lytic pathway.: Transplantation. 1999 Feb 15;67(3):435-43. Unique Identifier : AIDSLINE MED/99153363; Yi S; Feng X; Wang Y; Kay TW; Wang Y; O'Connell PJ; National Pancreas Transplant Unit, Westmead Hospital, NSW,; Australia.; BACKGROUND: In this study, the role of cell-mediated cytotoxicity by human leukocytes against pig endothelial cells was examined in vitro. The aim was to determine which cell subsets were responsible for this phenomenon and which pathways were involved in cell lysis. METHODS: Primed human peripheral blood mononuclear
Microsporidia infection in transplant patients.: Transplantation. 1999 Feb 15;67(3):482-4. Unique Identifier : AIDSLINE MED/99153370; Gumbo T; Hobbs RE; Carlyn C; Hall G; Isada CM; Department of Infectious Diseases, Cleveland Clinic Foundation,; Ohio 44195, USA.; BACKGROUND: Microsporidia are the most common cause of chronic diarrhea in patients infected with human immunodeficiency virus. Patients who have undergone organ transplantation may also be infected. The precise immune defect and the clinical picture in transplant patients have not been studied. METHODS: We report a c
Transmission of human immunodeficiency type 1 viruses with intersubtype recombinant long terminal repeat sequences.: Virology. 1999 Feb 15;254(2):220-5. Unique Identifier : AIDSLINE GENBANK/AF096657; Blackard JT; Renjifo BR; Mwakagile D; Montano MA; Fawzi WW; Essex M; Harvard AIDS Institute and the Department of Immunology and; Infectious Diseases, Department of Nutrition, Harvard School of; Public Health, 651 Huntington Avenue, Boston, Massachusetts,; 02115, USA.; Retroviruses such as human immunodeficiency virus type 1 (HIV-1) contain two RNA strands per virion, and recombination can occur frequently during reverse transcription. Recombination may occur between HIV-1 genomes of the same subtype or among genomes of two or more distinct subtypes present in an individual. In the
Subtype G and multiple forms of A/G intersubtype recombinant human immunodeficiency virus type 1 in Nigeria.: Virology. 1999 Feb 15;254(2):226-34. Unique Identifier : AIDSLINE GENBANK/AF069948; McCutchan FE; Carr JK; Bajani M; Sanders-Buell E; Harry TO; Stoeckli TC; Robbins KE; Gashau W; Nasidi A; Janssens W; Kalish ML; The Henry M. Jackson Foundation, 1600 East Gude Drive, Rockville,; Maryland, 20850, USA. fmccutchan@hiv.hjf.org; Multiple human immunodeficiency virus type 1 (HIV-1) genetic subtypes, intersubtype recombinants, and group O have been found in west central Africa. In Nigeria , where HIV-1 prevalence is rising rapidly, characterization of HIV-1 strains has been limited. Each of three full-length
Host range of human T-cell leukemia virus type I analyzed by a cell fusion-dependent reporter gene activation assay.: Virology. 1999 Feb 15;254(2):235-44. Unique Identifier : AIDSLINE MED/99143338; Okuma K; Nakamura M; Nakano S; Niho Y; Matsuura Y; Faculty of Medicine, Kyushu University, Fukuoka, 812-8582, Japan.; We constructed a sensitive and quantitative assay system to examine human T-cell leukemia virus type I (HTLV-I) envelope (env) glycoprotein-mediated cell fusion in which T7 RNA polymerase in donor cells coexpressing env glycoproteins activates a reporter gene in recipient cells upon cell fusion. An efficient expressio
Characterization of conformation-dependent anti-gp120 murine monoclonal antibodies produced by immunization with monomeric and oligomeric human immunodeficiency virus type 1 envelope proteins.: Virology. 1999 Feb 15;254(2):257-67. Unique Identifier : AIDSLINE MED/99143340; Sugiura W; Broder CC; Moss B; Earl PL; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland, 20892-0445, USA.; Twenty-five conformation-dependent monoclonal antibodies (MAbs) produced by immunization of mice with oligomeric forms of the human immunodeficiency virus type 1 (HIV-1) envelope (env) glycoprotein were used to map exposed, immunogenic regions on oligomeric env. Based on MAb cross-competition, reactivity with diverse
Sp1 is involved in a protein kinase C-independent activation of human T cell leukemia virus type I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate.: Virology. 1999 Feb 15;254(2):279-87. Unique Identifier : AIDSLINE MED/99143342; Torgeman A; Mor-Vaknin N; Aboud M; Faculty of Health Sciences, Ben Gurion University of the Negev,; Beer Sheva, 84105, Israel.; The long terminal repeat (LTR) of human T cell leukemia virus type-I (HTLV-I) contains binding sites for several cellular transcription factors that can activate its expression independently of the viral transactivator Tax protein. In a previous study, we have shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) indu
Envelope and long terminal repeat sequences of an infectious murine leukemia virus from a human SCLC cell line: implications for gene transfer.: Unique Identifier : AIDSLINE MED/99073700; Antoine M; Wegmann B; Kiefer P; Development of methods for gene transfer into specific cell types or tissues is important for experimental research as well as clinical therapeutical approaches. We report here the cloning and characterization of the envelope (env) gene and the U3 region of a retrovirus from an infected human Small Cell Lung Cancer (S
Amebic liver abscess: epidemiology, clinical features, and outcome.: West J Med. 1999 Feb;170(2):104-9. Unique Identifier : AIDSLINE MED/99162884; Seeto RK; Rockey DC; Department of Medicine, University of California, San Francisco,; USA.; Amebic liver abscess (ALA) is a serious, but readily treatable form of hepatic infection. In order to understand the clinical features of this condition in the United States , we reviewed the medical histories of 56 patients with ALA at two large San Francisco Hospitals from 1979 to 199
Role of the cell-mediated immune response in the pathogenesis of hepatitis B virus infection: possible immune-therapeutic strategies.: Acta Biomed Ateneo Parmense. 1996;67(3-4):87-93. Unique Identifier : AIDSLINE MED/99145719; Bertoletti A; Ferrari C; Fiaccadori F; Divisione Malattie Infettive e Immunopatologia Virale, Azienda; Ospedaliera di Parma.; Hepatitis B virus (HBV) infection usually leads to self-limited acute hepatitis with complete recovery of the patients and clearance of the virus from the circulation. However some patients (5 to 10%) do not clear the virus and they become chronic carriers, with or without evidence of liver disease. The sequence of ev
[Canine leishmaniasis. New concepts of epidemiology and immunopathology: their impact in the control of human visceral leishmaniasis]: Acta Med Port. 1998 Oct;11(10):871-5. Unique Identifier : AIDSLINE MED/99145807; Abranches P; Campino L; Santos-Gomes GM; Centro de Malaria e outras Doencas Tropicais, Instituto de; Higiene e Medicina Tropical, Lisboa.; Visceral leishmaniasis (VL) is a zoonosis in most regions where it occurs. Dogs are the most important reservoir of the disease and are mainly responsible for the persistence of VL in the Paleartic and Neotropical regions. Canine leishmaniasis (CaL) is a viscerocutaneous, chronic infection with a worse prognosis than
[Cellular immune response to mycobacterial antigens]: Acta Med Port. 1998 Oct;11(10):883-92. Unique Identifier : AIDSLINE MED/99145809; Ordway D; Moraes MF; Oliveira L; Badura R; Pinheiro MN; Graca JM; Carvalho L; Saldanha T; Abecasis P; Ventura FA; Centro de Malaria e Outras Doencas Tropicais/IHMT e Hospital; Egas Moniz, Lisboa.; The authors studied the immunological response before and after beginning anti-tuberculous therapy, of a previously health, HIV negative, 22 year old black male, from the Republic of Cape Verde . The patient had multiple vertebral bony lesions associated to subcutaneous abscesses
Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice.: J Bone Miner Res. 1999 Feb;14(2):256-63. Unique Identifier : AIDSLINE MED/99132548; Hjorth-Hansen H; Seifert MF; Borset M; Aarset H; Ostlie A; Sundan A; Waage A; Institute of Cancer Research and Molecular Biology, Norwegian; University of Science and Technology, Trondheim, Norway.; We report on an in vivo model of human myeloma producing bone disease in irradiated severe combined immunodeficiency disease mice using the human myeloma cell line JJN-3 and its subline JJN-3 T1. The cell lines are not Epstein-Barr virus transformed and produce large amounts of hepatocyte growth factor (HGF). Mice had
Renal manifestations of concurrent systemic lupus erythematosus and HIV infection.: Am J Kidney Dis. 1999 Mar;33(3):441-9. Unique Identifier : AIDSLINE MED/99168455; Chang BG; Markowitz GS; Seshan SV; Seigle RL; D'Agati VD; Department of Pathology, Columbia Presbyterian Medical Center,; New York, NY 10032, USA.; Autoimmune phenomena are common in human immunodeficiency virus (HIV) infection, yet systemic lupus erythematosus (SLE) and HIV infection rarely are seen concurrently in the same patient. Many of the cases of combined HIV infection and SLE reported in the literature are patients with SLE before HIV infection and who d
Nephrotic range proteinuria and hematuria in a white bisexual male.: Am J Kidney Dis. 1999 Mar;33(3):607-12. Unique Identifier : AIDSLINE MED/99168477; Paueksakon P; Grewal M; Shappell S; Department of Pathology, Vanderbilt University Medical Center,; Nashville, TN 37232, USA.
Bilateral upper-lobe cavitary Pneumocystis carinii pneumonia in a patient on dapsone prophylaxis.: Am J Med Sci. 1999 Feb;317(2):137-9. Unique Identifier : AIDSLINE MED/99154722; Jawahar DA; Dama S; Miarrostami R; Sadagdhar H; Anandarao N; Department of Medicine, New York Methodist Hospital, Brooklyn,; USA.; Pneumocystis carinii pneumonia (PCP) presenting as bilateral upper-lobe cavitary disease is rare. Isolated upper-lobe involvement has traditionally been associated with aerosolized pentamidine prophylaxis. Dapsone is a cheap and effective prophylactic agent against P carinii in patients who cannot tolerate trimethopri
Complementary therapies & HIV infection.: Unique Identifier : AIDSLINE MED/99155596; Evans BM; New Jersey AIDS Education and Training Center, University of; Medicine and Dentistry of New Jersey Center for Continuing; Education in the Health Professions, Newark, USA.
Legal considerations in screening pregnant women for human immunodeficiency virus.: Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):259-64. Unique Identifier : AIDSLINE MED/99143013; Grimes RM; Richards EP; Helfgott AW; Eriksen NL; Department of Management, Training Center for Texas and Oklahoma,; School of Public Health, Houston, Texas 7725-0186, USA.; This article examines the legal implications of studies showing that the probability of maternal-to-infant human immunodeficiency virus transmission can be reduced by physician interventions. These interventions require knowledge of a pregnant woman s human immunodeficiency status. Hence the offering of human immunode
Erythrocyte glutathione deficiency in symptom-free HIV infection is associated with decreased synthesis rate.: Am J Physiol. 1999 Jan;276(1 Pt 1):E205-11. Unique Identifier : AIDSLINE MED/99103918; Jahoor F; Jackson A; Gazzard B; Philips G; Sharpstone D; Frazer ME; Heird W; United States Department of Agriculture/Agricultural Research; Station Children's Nutrition Research Center, Department of; Pediatrics, Baylor College of Medicine, Houston, Texas 77030,; USA.; Although several studies have documented intra- and extracellular glutathione (GSH) deficiency in asymptomatic human immunodeficiency virus (HIV) infection, the mechanisms responsible for the altered GSH homeostasis remain unknown. To determine whether decreased synthesis contributes to this alteration of GSH homeosta
Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery.: Am J Surg. 1999 Jan;177(1):55-60. Unique Identifier : AIDSLINE MED/99154913; Brune IB; Wilke W; Hensler T; Holzmann B; Siewert JR; Department of Surgery, Klinikum rechts der Isar, Technical; University Munchen, Germany.; BACKGROUND: The clinical advantages of laparoscopic procedures result from a minimized surgical trauma. The present study was performed to investigate immunosupression following laparoscopic operations as compared with open surgery. Our analysis focused on the T cell secretion of cytokines that regulate the critical b
BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation.: Anal Biochem. 1999 Jan 1;266(1):9-15. Unique Identifier : AIDSLINE MED/99105763; O'callaghan CA; Byford MF; Wyer JR; Willcox BE; Jakobsen BK; McMichael AJ; Bell JI; Nuffield Department of Clinical Medicine, University of Oxford,; Oxford, OX3 9DS, United Kingdom.; The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. We report a rapid, efficient, and economical method for the production, purification, and application of this enzyme. The method is easily scaled up and the protein produced is of high purit
DNA biochip using a phototransistor integrated circuit.: Anal Chem. 1999 Jan 15;71(2):358-63. Unique Identifier : AIDSLINE MED/99134886; Vo-Dinh T; Alarie JP; Isola N; Landis D; Wintenberg AL; Ericson MN; Oak Ridge National Laboratory, Tennessee 37831-6101, USA.; This work describes the development of an integrated biosensor based on phototransistor integrated circuits (IC) for use in medical detection, DNA diagnostics, and gene mapping. The evaluation of various system components developed for an integrated biosensor microchip is discussed. Methods to develop a microarray of
Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.: Ann Intern Med. 1999 Mar 16;130(6):510-4. Unique Identifier : AIDSLINE MED/99165399; Gulick RM; McAuliffe V; Holden-Wiltse J; Crumpacker C; Liebes L; Stein DS; Meehan P; Hussey S; Forcht J; Valentine FT; New York University Medical Center, New York, USA.; BACKGROUND: Hypericin, the active compound in St. John s Wort, has antiretroviral activity in vitro. Many HIV-infected persons use St. John s wort. OBJECTIVE: To evaluate the safety and antiretroviral activity of hypericin in HIV-infected patients. DESIGN: Phase I study. SETTING: Four clinical research units. PATIENTS
Laryngeal pathology in the acquired immunodeficiency syndrome: diagnostic and therapeutic dilemmas.: Ann Otol Rhinol Laryngol. 1999 Feb;108(2):214-20. Unique Identifier : AIDSLINE MED/99153316; Tami TA; Ferlito A; Rinaldo A; Lee KC; Singh B; Department of Otolaryngology-Head and Neck Surgery, University of; Cincinnati, Ohio, USA.; The acquired immunodeficiency syndrome has produced a growing population of patients who, because of their associated immune system compromise, are prone to opportunistic infections and neoplastic diseases. The larynx, with its relatively inaccessible yet critical anatomic location, is a site in which these processes
[Oral antitumor drugs for hematological malignancies]: Gan To Kagaku Ryoho. 1999 Feb;26(3):295-300. Unique Identifier : AIDSLINE MED/99164485; Ohnishi K; Dept. of Internal Medicine III, Hamamatsu University School of; Medicine.; The oral antitumor drugs against hematological malignancies are summarized. Sobuzoxane, a topoisomerase II inhibitor, is useful for the treatment of lymphoma, especially adult T cell leukemia/lymphoma. Sobuzoxane has an effect to protect against doxorubicin cardiotoxicity. Cytarabine ocfosfate, a derivative of cytosin
Parotid lipomatosis in HIV positive patients: a new clinical disorder associated with protease inhibitors [letter]: Ann Rheum Dis. 1998 Dec;57(12):749. Unique Identifier : AIDSLINE MED/99169431; Olive A; Salavert A; Manriquez M; Clotet B; Moragas A
[Colorectal diseases in AIDS patients and endoscopic findings]: Arq Gastroenterol. 1998 Apr-Jun;35(2):104-9. Unique Identifier : AIDSLINE MED/99031918; Averbach M; Cutait R; Correa P; Duarte MI; Leite K; Borges JL; Hospital Sirio Libanes, Sao Paulo.; In order to establish which are the most frequent endoscopic detectable colorectal disorders in AIDS patients with intestinal complaints we analysed 236 colonoscopies in a series of 186 patients. The colonoscopic procedure was always followed by biopsies, even in the absence of macroscopic lesions. The most frequent d
Clinical patterns of diarrhea in AIDS. A retrospective study at the Federal University Hospital, Rio de Janeiro.: Arq Gastroenterol. 1998 Apr-Jun;35(2):95-9. Unique Identifier : AIDSLINE MED/99031916; Elia C; Fogaca HS; de Souza HS; Belo MT; Elia PP; Pimentel ML; Fang HL; Laboratorio Multidisciplinar de Pesquisa, Hospital; Universitario Clementino Fraga Filho, Universidade Federal do; Rio de Janeiro, Brasil.; Three hundred and fifty two medical records of AIDS inpatients were analysed in a retrospective study to establish the frequency, clinical patterns and etiology of AIDS-related diarrhea. Diarrhea was observed in 58.8% of the patients, being a chronic symptom in 65.7%, and the first complaint in 24.6%. The most common
The search for more intelligent therapy.: GMHC Treat Issues. 1998 Jul-Aug;12(7-8):1-6. Unique Identifier : AIDSLINE AIDS/99704038; Gilden D; The prevailing view at the 12th International AIDS Conference was more somber than at the previous International AIDS Conference, where the first three protease inhibitors were announced. Speakers at the more recent conference noted that the 15 approved antiviral dr
Hydroxyurea becomes the talk of Geneva.: GMHC Treat Issues. 1998 Jul-Aug;12(7-8):6-9. Unique Identifier : AIDSLINE AIDS/99704039; Santiago L; Several developments related to Hydroxyurea (HU) were described at the 12th World AIDS Conference. HU was shown effective in combination with other drugs in substantially reducing viral loads. One study showed that HU increases the capacity of two new drugs, adefovir and PMPA, to achieve viral suppression, even with t
Debate widens over protease inhibitor side effects.: GMHC Treat Issues. 1998 Jul-Aug;12(7-8):9-12. Unique Identifier : AIDSLINE AIDS/99704040; Cadman J; Unusual abnormalities continue to be reported among HIV patients on highly active antiretroviral therapy (HAART), with many of these symptoms being reported worldwide. One of the most distressing symptoms is abnormal redistribution of body fat (lipodystrophy). There is no clear-cut cause identified with lipodystrophy,
Working to improve pregnancy outcomes.: GMHC Treat Issues. 1998 Jul-Aug;12(7-8):13-4. Unique Identifier : AIDSLINE AIDS/99704041; Cadman J; Research to eliminate mother-to-child HIV transmission was a highlight at the 12th World AIDS Conference. ACTG 076 demonstrated that a three-part course of AZT can reduce the vertical transmission rate by 67 percent. Studies assessing the effectivenes
Ritonavir users put on liquid diet.: GMHC Treat Issues. 1998 Jul-Aug;12(7-8):15-6. Unique Identifier : AIDSLINE AIDS/99704042; Cadman J; Abbott Laboratories has announced that production problems are halting the manufacturing of the capsule formulation of Ritonavir ( Norvir ), althou
PIT study produces more questions than answers.: Treat Update. 1998 Jul;10(5):1-2. Unique Identifier : AIDSLINE AIDS/99704043; Some researchers believe that anti-HIV antibodies have a role in controlling HIV infection. A study involving passive immunotherapy (PIT), a process in which antibodies from symptom-free HIV-positive volunteers are infused into HIV-positive subjects with far fewer CD4+ cells, showed that receiving PIT is safe, but its
Donating antibodies as a treatment for HIV.: Treat Update. 1998 Jul;10(5):2-3. Unique Identifier : AIDSLINE AIDS/99704044; Removing protective antibodies from healthy, symptom-free, HIV-positive people does not appear to have a negative impact on their health. A 3-year study monitoring and analyzing blood cell count changes in groups of people, including 26 passive immunotherapy (PIT) donors, suggests that regular removal of anti-HIV anti
Azithro once a week for MAC.: Treat Update. 1998 Jul;10(5):3-4. Unique Identifier : AIDSLINE AIDS/99704045; Azithromycin (Zithromax) has been used to treat a number of infections, including mycobacterium avium complex (MAC). A study using Azithromycin to prevent MAC shows the drug s effectiveness in reducing the outbreak of MAC and also protecting from other infections, including PCP. This study involved 180 HIV-positive su
Essiac for cancer?: Treat Update. 1998 Jul;10(5):4-5. Unique Identifier : AIDSLINE AIDS/99704046; An analysis of a mixture of herbs in Essiac, an alternative-medicine anti-cancer therapy, has shown it contains a variety of compounds which have antioxidant activity as well as the ability to block cell growth. The Essiac mixture contains burdock root, Indian rhubarb, sheep sorrel, inner bark of slippery elm, watercr
Carnitine may boost T cell counts.: Treat Update. 1998 Jul;10(5):4-6. Unique Identifier : AIDSLINE AIDS/99704047; Studies are showing the efficacy of an amino acid, called Carnitine, in boosting CD4+ counts by decreasing the number of cells undergoing apoptosis, a self-destruct process. Eleven HIV-positive, symptom-free subjects, who were also infected with hepatitis C virus, received 6 grams of Carnitine intravenously daily for
Surviving HIV in small town U.S.A.: Posit Aware. 1998 Jul-Aug;9(4):28-9, 51. Unique Identifier : AIDSLINE AIDS/99704048; Whitfield L; People with HIV face special problems when living in rural communities. Many have to travel long distances for health care and may have difficulty finding doctors with experience in treating HIV disease. HIV is spreading rapidly throughout smaller communities partly because of barriers to educational and prevention pr
Treatment issues in rural America.: Posit Aware. 1998 Jul-Aug;9(4):31. Unique Identifier : AIDSLINE AIDS/99704049; Whitson S; Rural HIV-positive populations are rapidly increasing in size and will present the health care system with formidable challenges. Treatment is sometimes difficult in rural communities, and ignorance and denial interfere with effective medical treatment. A Utah study of rural physicians found that of 169 respondents, 9
Health care strategies in rural America.: Posit Aware. 1998 Jul-Aug;9(4):38-40. Unique Identifier : AIDSLINE AIDS/99704050; Whitfield L; In 1993, members of the National AIDS Commission were shocked by the number of physicians still refusing to care for AIDS patients. Bill Pickney, a physician in Arkansas, says that the situation has changed today, and health care providers are more sensitive about health care than they used to be. However, there seems
Lessons on rural sensitivity.: Posit Aware. 1998 Jul-Aug;9(4):44-5. Unique Identifier : AIDSLINE AIDS/99704051; Whitfield L; Tolerance toward HIV-positive individuals is virtually non-existent in some rural communities, and patients in these communities have routinely experienced harassment and discrimination. Several patients experiences are detailed, and a number of providers believe that stigmatization has increased in small communities
Comparing Oxandrin and Anadrol-50.: Posit Aware. 1998 Jul-Aug;9(4):49-51. Unique Identifier : AIDSLINE AIDS/99704052; Vazquez E; Oxandrin and Anadrol-50 are both oral anabolic steroids approved by the Food and Drug Administration ( FDA ), and they are competing for market share in the world of HIV treatments. Both are described as open label drugs and as such, are prescribed to reverse wasting and metabolic com
New data on IL-2.: Unique Identifier : AIDSLINE AIDS/99704053; Whitson S; A new study to be presented at the 12th World AIDS Conference demonstrates that IL-2 dramatically restores immune function in people with AIDS. The study group included patients with fewer than 200 CD4-cells and a history of severe AIDS-related complications including
Thalidomide's comeback.: Posit Aware. 1998 Jul-Aug;9(4):53-4. Unique Identifier : AIDSLINE AIDS/99704054; Vazquez E; Thalidomide shows a significant ability to eliminate painful mouth ulcers in HIV patients and is also effective in reversing wasting and clearing up severe diarrhea caused by microsporidiosis . However, the drug comes with several side effects. Side effects include
The search for a cure.: World. 1998 Jul;(No 87):3. Unique Identifier : AIDSLINE AIDS/99704069; Sharp M; University of California San Francisco, CA.; Finding drugs that may treat or cure HIV is a tedious and lengthy process. The challenges for finding such drugs, including how those drugs are discovered and tested, are explained. One approach to drug development is to design drugs that specifically target part of the viral life cycle. Reverse transcriptase inhibito
Meeting highlights: European Association for the Study of the Liver.: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):14-22. Unique Identifier : AIDSLINE AIDS/99704070; MacDougall DS; The 1998 33rd annual meeting of the European Association for the Study of the Liver examined the latest advances in the diagnosis and treatment of liver disease. Highlights of the meeting include discussions on hepatitis B (HBV) or hepatitis C (HCV) infection recurrence after liver transplantation, treatment of chroni
Hepatitis B and breastfeeding. World Health Organization.: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):20-1. Unique Identifier : AIDSLINE AIDS/99704071; World Health Organization, Geneva, Switzerland.; A joint statement from the Global Programme for Vaccines and Immunization and the Division of Child Health and Development, and Reproductive Health of the World Health Organization discusses whether breastfeeding is a significant factor in transmitting hepatitis B virus (HBV). In count
Can science meet the challenges of the HCV pandemic: new treatment options for chronic hepatitis C.: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):24-9. Unique Identifier : AIDSLINE AIDS/99704072; Roehr B; New treatment options for chronic hepatitis C (HCV) infection are examined. Studies show the efficacy of interferon alfa-2b in normalization of serum alanine aminotransferase and histological improvement in necroinflammatory liver disease. However, 70 to 80 percent experiencing normalization usually relapse within 1 y
HIV/HCV coinfection.: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):30. Unique Identifier : AIDSLINE AIDS/99704073; Roehr B; Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often coinfected with other types of hepatitis viruses and/or HIV. Physicians may miss diagnosing HCV infection in their HIV patients, because the HCV antibody test often does not detect HCV infection when a patient is also in
Treating hepatitis C: a clinician's perspective. [interview by Bob Roehr]: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):31-5. Unique Identifier : AIDSLINE AIDS/99704074; Powell J; Dr. Jerry Powell, Director of the Hemophilia Treatment Center at the University of California, provides a clinician s perspective on hepatitis C (HCV) therapy. He believes the Food and Drug Administration s ( FDA ) approved interferon dosing regimen is not appropriate. Interferon, he be
Mosaic of the AIDS epidemics in Latin America and the Caribbean.: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):36-7. Unique Identifier : AIDSLINE AIDS/99704075; Cuchi P; Patz D; Pan American Health Organization, Regional Program on AIDS/STD,; Washington, DC.; In Latin America and the Caribbean, the AIDS pandemic is comprised of groupings of different epidemics, varying in transmission routes and in populations affected. Primary modes of HIV transmission in Latin America, the Caribbean, and South America are outlined, and vary from type of sexual contact to intravenous drug
Culture-sensitive campaign targets hepatitis awareness.: J Int Assoc Physicians AIDS Care. 1998 Jul;4(7):38-40. Unique Identifier : AIDSLINE AIDS/99704076; MacDougall DS; A new U.S. public service announcement (PSA) campaign is attempting to reach those at greatest risk of contracting viral hepatitis. The campaign incorporates a culturally diverse outreach initiative targeting African Americans, Hispanics, gay men, and others at increased risk for infection. The campaign design recogni
I hear you knockin' (but you can't come in): potent new HIV therapies are shutting out opportunistic infections.: RITA Newsl. 1998 Jul;4(4):3-7. Unique Identifier : AIDSLINE AIDS/99704077; Fichtenbaum CJ; Washington University School of Medicine, Saint Louis, MO.; Highly active antiretroviral therapy (HAART) has positively impacted the epidemiology of opportunistic infections in HIV- infected patients. The following opportunistic infections and their responses to HAART and prophylaxis recommendations are examined: pneumocystis carinii pneumonia (PCP),
Just sweat it out: physical therapy's role in the HIV pandemic.: RITA Newsl. 1998 Jul;4(4):8-10. Unique Identifier : AIDSLINE AIDS/99704078; Sacky K; Shankle D; Hobbs J; The changing role of physical therapy in treating patients with HIV infection is examined. Physical therapy appears beneficial in its use in relieving peripheral neuropathic pain and pain attributed to musculoskeletal problems related to wasting, prolonged bed rest, HIV myalgia, or pre-existing conditions exacerbated
HIV/AIDS clinical trials in Houston.: RITA Newsl. 1998 Jul;4(4):11-3. Unique Identifier : AIDSLINE AIDS/99704079; A list of clinical trials available in Houston, Texas is provided. Each trial is described, including location and contact information. Information concerning clinical trials can be obtained from the AIDS Clinical Trials Information Service (ACTIS). Contact information for ACTIS is provided.
Simply stated...on your mark, get set, go.: RITA Newsl. 1998 Jul;4(4):15. Unique Identifier : AIDSLINE AIDS/99704080; A simplified version of antiretroviral treatment guidelines for people with HIV infection provides information for patients and physicians on when to begin treatment, and when the regimen needs to be changed. The guidelines, developed by the Department of Health and Human Services and National Institutes of Health, gi
New abacavir data open door to a better treatment paradigm.: AIDS Alert. 1998 Aug;13(8):85-7. Unique Identifier : AIDSLINE AIDS/99704081; Abacavir (ABC), an experimental nucleoside reverse transcriptase inhibitor created by Glaxo Wellcome , appears as effective in combination therapy as
Would use of specialists improve patient care?: AIDS Alert. 1998 Aug;13(8):87-9. Unique Identifier : AIDSLINE AIDS/99704082; Patients who are cared for by doctors with less experience in HIV care often receive incorrect drug regimens. Findings from the National HIV/AIDS Treatment Survey show that HIV guidelines are frequently not followed, and doctors with limited HIV experience are more likely to delay treatment and prescribe fewer drugs t
Treatment successes draining ADAP resources.: AIDS Alert. 1998 Aug;13(8):88. Unique Identifier : AIDSLINE AIDS/99704083; The financial resources of AIDS Drug Assistance Programs (ADAPs) are threatened by the costs of combination therapies for uninsured and underinsured patients. ADAPs function as joint Federal and State programs that cover the costs of medications for such patients, but officials estimate that they will need a minimum o
Notification guidelines finally being published.: AIDS Alert. 1998 Aug;13(8):89-90. Unique Identifier : AIDSLINE AIDS/99704084; The Centers for Disease Control and Prevention (CDC) has completed draft guidelines for HIV partner notification programs, four years after the guidelines were first initiated. The guidelines are part of the Ryan White reauthorization law, which requires States to try implementing partner notification programs. It is
Action plans needed for willful transmissions.: AIDS Alert. 1998 Aug;13(8):90-2. Unique Identifier : AIDSLINE AIDS/99704085; Recent cases involving persons willfully and deliberately infecting others with HIV have highlighted the need for public health departments to develop action plans to address these issues. The case of LaShawn Williams in New York demonstrated the need for cohesive, cross-agency plans to deal with cluster infections. T
Identifiers are coming, but names or numbers?: AIDS Alert. 1998 Aug;13(8):93-4. Unique Identifier : AIDSLINE AIDS/99704086; The Centers for Disease Control and Prevention (CDC) is discouraging unique identifier- based reporting programs for AIDS cases in favor of a name-based reporting program. Several States are moving in the direction of unique identifier-based reporting, but may find that they will not be getting desired support from th
New CDC program focuses on those already infected. Centers for Disease Control and Prevention.: AIDS Alert. 1998 Aug;13(8):94-6. Unique Identifier : AIDSLINE AIDS/99704087; The Centers for Disease Control and Prevention (CDC) is instituting a program to provide comprehensive HIV prevention services to those already infected. The goal is to prevent HIV positive people from transmitting the infection to others. Up to five long term demonstration projects will be funded with $3.9 million to
What you need to know about HIV Type 2.: AIDS Alert. 1998 Aug;13(8):suppl 1-2. Unique Identifier : AIDSLINE AIDS/99704088; Few people know that there are two types of HIV infections, HIV-1 and HIV-2. The predominant version in the United States is HIV-1. Only 77 cases of HIV-2 have been identified in this country. HIV-2 is more predominant in West Africa, and patients infected with HIV-2 seem to progress t
Drug makers to cut prices for developing countries.: AIDS Alert. 1998 Aug;13(8 Suppl):1-2. Unique Identifier : AIDSLINE AIDS/99704089; As a result of negotiations between drug manufacturers and UNAIDS , a two-tiered pricing scheme has been developed to offer AIDS medicines to developing countries at significantly lower prices than are paid in the West. The two-tiered pricing will offer one price for developed count
Weighing options with yardstick called 'DALY'.: AIDS Alert. 1998 Aug;13(8 Suppl):4. Unique Identifier : AIDSLINE AIDS/99704090; Developing countries need to measure which medical interventions are cost-effective, and some are using a new measurement called Disability Adjusted Life Years (DALY). DALY incorporates data about how productive people are at various stages of their life and probabilities related to their life expectancy. The process
New plan seeks to reinvigorate HIV prevention efforts.: AIDS Policy Law. 1998 Aug 7;13(14):1, 4. Unique Identifier : AIDSLINE AIDS/99704091; AIDS Action has proposed a plan for increased Federal funding and greater public awareness for the prevention of HIV infections. The virtual vaccine plan requests a 25 percent increase in the Centers for Disease Control and Prevention s $634 million budget for HIV prevention programs. Other portions of the plan incl
Survey reveals continued public unease about HIV.: AIDS Policy Law. 1998 Aug 7;13(14):1, 6-7. Unique Identifier : AIDSLINE AIDS/99704092; A team of researchers led by Gregory Herek from the University of California at Davis, conducted an opinion survey about the transmission of HIV infections. The survey found that many Americans maintain incorrect beliefs about HIV transmission from casual contact. A similar survey was conducted in 1991, but the 1998 s
Prison guard loses bid to kill HIV disclosure lawsuit.: AIDS Policy Law. 1998 Aug 7;13(14):2. Unique Identifier : AIDSLINE AIDS/99704093; Elizabeth Colon, an inmate at a women s prison in New York State, can proceed with her civil rights lawsuit against a prison guard who revealed her HIV status. A U.S. District Court judge has denied the guard s motion to dismiss the case. Citing previous case law, the judge stated that the guard violated Colon s const
3rd Circuit upholds condom program in high schools.: AIDS Policy Law. 1998 Aug 7;13(14):3. Unique Identifier : AIDSLINE AIDS/99704094; The 3rd Circuit Court of Appeals unanimously affirmed a lower court s ruling that the condom program authorized by the Philadelphia School Board is voluntary and therefore has not violated State law or infringed on parental rights. Since 1991, the program has made condoms available to 9th through 12th grade students i
Court lets hotel guest keep $250,000 award for needlestick.: AIDS Policy Law. 1998 Aug 7;13(14):5. Unique Identifier : AIDSLINE AIDS/99704095; Patsy Slone, a guest at the Dollar Inn in September 1988, was stabbed in the thumb by a hypodermic needle hidden in a roll of toilet paper. Told by a hotel employee that the needle was probably left by an injection-drug user on staff, Slone went to a hospital for blood tests. Hospital staff erroneously informed Slone
Report seeks more research on effects of AIDS stigma.: AIDS Policy Law. 1998 Aug 7;13(14):7. Unique Identifier : AIDSLINE AIDS/99704096; A report presented to the National Institute of Mental Health suggests the need to study the psychosocial effects of the stigma associated with AIDS. Much of the previous research has been based on anecdotal information. A more aggressive approach that would explain some of the effects would help government leaders an
CDC to let States decide whether to ask teens about sex. Centers for Disease Control and Prevention.: AIDS Policy Law. 1998 Aug 7;13(14):7. Unique Identifier : AIDSLINE AIDS/99704097; The Centers for Disease Control and Prevention has eliminated a question about whether teenagers engage in same sex behavior from its 1999 Youth Risk Behavior Survey. Every two years, this survey asks high school students a variety of questions about health, sexual behavior, nutrition, drug and alcohol use, and smokin
Hospital's refusal to test needle leaves it open to suit.: AIDS Policy Law. 1998 Aug 7;13(14):8. Unique Identifier : AIDSLINE AIDS/99704098; Courts in New York State require plaintiffs in fear-of-AIDS cases to prove exposure to HIV in order to collect damages for negligent infliction of emotional distress. When Beth Fosby suffered a needlestick injury at Albany Memorial Hospital in September 1994, she sued the hospital. The hospital never furnished a copy
Job applicant claims HIV bias blocks his return to work.: AIDS Policy Law. 1998 Aug 7;13(14):8. Unique Identifier : AIDSLINE AIDS/99704099; William Ellsworth is suing the Houston Independent School District for refusing to hire him for a teaching position based on his HIV status. Ellsworth contends that the school district rejected him in favor of less qualified applicants which is in violation of the Americans with Disabilities Act (ADA). An investigatio
Fired worker fails to meet ADA's 'regarded as' test.: AIDS Policy Law. 1998 Aug 7;13(14):9. Unique Identifier : AIDSLINE AIDS/99704100; Jeffrey DeFilippo, a waiter at a Long Island Red Lobster, claimed that he was fired based on the misconception that because he was gay, he was HIV-positive. DeFilippo sued under the Federal Rehabilitation Act and the Americans with Disabilities Act, because there is not a law in NY that protects people from discrimina
Arkansas warden faces retrial on inmate's HIV rape allegation.: AIDS Policy Law. 1998 Aug 7;13(14):9-10. Unique Identifier : AIDSLINE AIDS/99704101; Kendell Spruce, a prison inmate in Arkansas, claimed he was raped by his cell mate and infected with HIV because the prison warden failed to protect him. The 8th Circuit Court agreed with Spruce by reversing a Federal judge s previous decision against Spruce. A document bearing the warden s signature indicated that th
Arizona to let caregivers learn victims' HIV status.: AIDS Policy Law. 1998 Aug 7;13(14):10-1. Unique Identifier : AIDSLINE AIDS/99704102; Senate Bill 1037, which takes effect August 22, 1998, will let good Samaritans in Arizona learn whether a person they help in an accident is infected with HIV. The caregiver may request the information from local health departments or from the State Department of Health, but only in cases where exposure to the victi
Nine prison officers charged in beating of HIV-positive inmate.: AIDS Policy Law. 1998 Aug 7;13(14):11. Unique Identifier : AIDSLINE AIDS/99704103; John Edwards, an HIV-positive inmate at Charlotte Correctional Institution, attempted suicide after several corrections officers and supervisors allegedly punched and kicked him over a period of three days. When Edwards was found, his wounds were bandaged, and he was chained to a bed in the psychiatric unit. The abuse
Assault trial set.: AIDS Policy Law. 1998 Aug 7;13(14):12. Unique Identifier : AIDSLINE AIDS/99704104; Brian Stewart, a former phlebotomist in Columbia, Illinois, has been charged with first-degree assault. He is accused of injecting his infant son with HIV-tainted blood to avoid paying child support. Prosecutors contend that Stewart injected his son with contaminated blood in February 1992, when the boy was in the hos
[DuPont-Pharma Laboratories. Sustiva (news)]: Allerg Immunol (Paris). 1998 Nov;30(9):302. Unique Identifier : AIDSLINE MED/99104938
Artificial neural network method for predicting HIV protease cleavage sites in protein.: J Protein Chem. 1998 Oct;17(7):607-15. Unique Identifier : AIDSLINE MED/99068564; Cai YD; Yu H; Chou KC; Shanghai Research Centre of Biotechnology, Chinese Academy of; Sciences.; Knowledge of the polyprotein cleavage sites by HIV protease will refine our understanding of its specificity, and the information thus acquired will be useful for designing specific and efficient HIV protease inhibitors . The search for inhibitors of HIV protease wil
Cytokine expression by first-trimester human chorionic villi.: Am J Reprod Immunol. 1998 Nov;40(5):309-18. Unique Identifier : AIDSLINE MED/99086897; Bennett WA; Lagoo-Deenadayalan S; Stopple JA; Barber WH; Hale E; Brackin MN; Cowan BD; Department of Obstetrics and Gynecology, University of; Mississippi Medical Center, Jackson, USA.; PROBLEM: Communication at the human maternal-fetal interface occurs by an intricate cytokine network. This study examines cytokine expression by normal first-trimester human chorionic villi. METHOD OF STUDY: Tissues were obtained at elective pregnancy terminations (7-9 weeks). Total RNA was isolated from chorionic vil
Brain biopsy in AIDS patients: what are the indications? [editorial]: Br J Neurosurg. 1998 Aug;12(4):301-4. Unique Identifier : AIDSLINE MED/99169573; Whittle IR; Leen C
Responses of CD8(+) T cells to intracellular bacteria.: Curr Opin Immunol. 1999 Feb;11(1):89-93. Unique Identifier : AIDSLINE MED/99158666; Harty JT; Bevan MJ; Department of Microbiology, Interdisciplinary Graduate Program in; Immunology, University of Iowa, Iowa City 52242, USA.; john-harty@uiowa.edu.; Recent studies of CD8(+) T cell responses against intracellular bacteria have provided insights into the relevance of the exogenous and endogenous MHC class I presentation pathways during the priming and effector stages. The capacity of these organisms to deliver vaccine antigens, either as bacterial protein or as pla
Analysis of changes during subclone development and ageing of human antibody-producing heterohybridoma cells by northern blot and flow cytometry.: J Biotechnol. 1999 Jan 8;67(1):57-66. Unique Identifier : AIDSLINE MED/99142337; Borth N; Strutzenberger K; Kunert R; Steinfellner W; Katinger H; Institute for Applied Microbiology, University of Agriculture,; Vienna, Austria. borth@mail.boku.ac.at; The economic importance of obtaining high-producing subclones for large scale production of pharmaceutical proteins is self-evident. However, few papers have studied the changes that occur during subclone development. This information would be important for further improvement of screening and subcloning protocols. We
Effects of an HIV risk reduction project on sexual risk behavior of low-income STD patients.: AIDS Educ Prev. 1998 Dec;10(6):483-92. Unique Identifier : AIDSLINE MED/99099737; O'Leary A; Ambrose TK; Raffaelli M; Maibach E; Jemmott LS; Jemmott JB 3rd; Labouvie E; Celentano D; Rutgers University Department of Psychology, New Brunswick, NJ,; USA.; A 10-hour small-group informational and skill-building intervention was tested among patients (N = 472) attending publicly funded sexually transmitted disease clinics in Maryland, Georgia , and New Jersey. After completing a 90-minute interview concerning HIV risk behaviors, condom
Maintenance of safe sex behavior by HIV-serodiscordant heterosexual couples.: AIDS Educ Prev. 1998 Dec;10(6):493-505. Unique Identifier : AIDSLINE MED/99099738; Skurnick JH; Abrams J; Kennedy CA; Valentine SN; Cordell JR; Department of Preventive Medicine and Community Health, UMDNJ-New; Jersey Medical School, Newark 07103-2714, USA.; We present findings from a prospective study of heterosexual HIV transmission in stable New Jersey couples who are serodiscordant for HIV and in which the uninfected partner is at risk solely from heterosexual contact. One hundred thirty-one couples were interviewed at enrollment and 6-month follow-up. This report des
An investigation of the effects of HIV on the sex lives of infected individuals.: AIDS Educ Prev. 1998 Dec;10(6):506-22. Unique Identifier : AIDSLINE MED/99099739; Cranson DA; Caron SL; College of Education and Human Development, University of Maine,; Orono 04469, USA.; The current study was designed to provide an in-depth description of the experiences of 29 persons living with a seropositive status, specifically addressing the issues of how this affects intimate partner relationships and sexual self-image. Data were collected using a 25-question, open-ended interview instrument. Da
A preliminary evaluation of a modified needle-cleaning intervention using bleach among injection drug users.: AIDS Educ Prev. 1998 Dec;10(6):523-32. Unique Identifier : AIDSLINE MED/99099740; Carlson RG; Wang J; Siegal HA; Falck RS; Department of Community Health, Wright State University School of; Medicine, Dayton, OH 45435, USA. rcarlson@wright.edu; This study examines an intervention designed to improve needle-cleaning practices among injection drug users (IDUs) in Dayton and Columbus, Ohio, to meet the recommended bleach exposure time of at least 30 seconds. Simulated needle-cleaning practices were observed in offices at baseline and after an intervention at 2
Alcohol and AIDS-related sexual behavior among Hispanics: acculturation and gender differences.: AIDS Educ Prev. 1998 Dec;10(6):533-47. Unique Identifier : AIDSLINE MED/99099741; Hines AM; Caetano R; College of Social Work, San Jose State University, CA, USA.; We examined the relationship of acculturation to alcohol use and risky sexual behavior among Hispanic men (N = 269) and women (N = 294). Data were obtained from a 1991/1992 general population survey on alcohol that included questions on sexual behavior. Guided by a conceptual/theoretical framework, we focused on gende
Condom use as a dependent variable: measurement issues relevant to HIV prevention programs.: AIDS Educ Prev. 1998 Dec;10(6):548-57. Unique Identifier : AIDSLINE MED/99099742; Crosby RA; Rural Center for AIDS/STD Prevention, Indiana University,; Bloomington 47405-3085, USA.; The value of condoms in efforts to slow the spread of HIV infection has been well established in the literature. Behavioral science faces the challenge of promoting condom use through intervention programs. As these programs are evaluated, multiple issues should be considered in relation to measuring participant use o
Evaluation of an AIDS training program for traditional healers in the Central African Republic.: AIDS Educ Prev. 1998 Dec;10(6):558-64. Unique Identifier : AIDSLINE MED/99099743; Somse P; Chapko MK; Wata JB; Bondha P; Gonda B; Johnson D; Downer A; Kimball AM; Ministry of Health, Central African Republic.; Training designed to improve AIDS knowledge, attitude, and practice was delivered to 96 traditional healers in the Central African Republic . The training (17 to 36 hours) was conducted by traditional healers with the assistance of staff from the Ministry of Health.
HIV-related attitudes and risk behavior of young adolescent mothers.: AIDS Educ Prev. 1998 Dec;10(6):565-73. Unique Identifier : AIDSLINE MED/99099744; Brown LK; Lourie KJ; Flanagan P; High P; Rhode Island Hospital, Brown University School of Medicine,; Providence 02903, USA.; This article reports on the prevalence of HIV-related risk behaviors among young adolescent mothers. To determine the facilitators and barriers to condom use for young adolescent mothers, a survey of HIV-related knowledge, attitudes and behavior and focus groups was conducted. Young mothers (N = 58) have basic knowled
AIDS-associated lymphoma.: Cancer Treat Res. 1999;99:241-66. Unique Identifier : AIDSLINE MED/99109019; Volm MD; Von Roenn JH; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois 60611, USA.
Epstein-Barr virus and lymphoma.: Cancer Treat Res. 1999;99:27-45. Unique Identifier : AIDSLINE MED/99109011; Ambinder RF; Lemas MV; Moore S; Yang J; Fabian D; Krone C; John Hopkins Oncology Center, Oncology Center, Baltimore,; Maryland 21231, USA.
Hodgkin's lymphoma in a pregnant patient with acquired immunodeficiency syndrome.: Clin Oncol (R Coll Radiol). 1998;10(6):410-1. Unique Identifier : AIDSLINE MED/99105553; Okechukwu CN; Ross J; University of Connecticut Health Center, Farmington 06032, USA.; The occurrence of Hodgkin s lymphoma in pregnancy is unusual; its management poses not only medical but also ethical problems. We report the case history of a pregnant patient with acquired immunodeficiency syndrome and Hodgkin s lymphoma. Combination chemotherapy was given, with a favourable outcome for the foetus. F
The induction of transplantation tolerance by intrathymic (i.t.) delivery of alloantigen: a critical relationship between i.t. deletion, thymic export of new T cells and the timing of transplantation.: Int Immunol. 1998 Nov;10(11):1637-46. Unique Identifier : AIDSLINE MED/99061149; Jones ND; Fluck NC; Mellor AL; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, Headington, UK.; Intrathymic (i.t.) injection of donor alloantigens has proved to be an effective strategy for the induction of tolerance. However, the mechanisms by which tolerance is induced and maintained after transplantation remain unclear. In this report we show that tolerance to donor cardiac allografts can be induced across a
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.: Int Immunol. 1998 Nov;10(11):1647-55. Unique Identifier : AIDSLINE MED/99061150; Mark DA; Donovan CE; De Sanctis GT; Krinzman SJ; Kobzik L; Linsley PS; Sayegh MH; Lederer J; Perkins DL; Finn PW; Pulmonary Division, Brigham and Women's Hospital, Boston, MA; 02115, USA.; We examined the roles of CD80 (B7-1) and CD86 (B7-2) in a model of allergic pulmonary inflammation and airway hyper-responsiveness (AHR) by selectively inhibiting either CD80 or CD86. Inhibition of co-stimulation by either CD80 or CD86 affected multiple parameters of the allergic response. Specifically, blockade of ei
Effect of interleukin-12 and interleukin-10 on the virus replication and apoptosis in T-cells infected with feline immunodeficiency virus.: J Vet Med Sci. 1998 Nov;60(11):1181-5. Unique Identifier : AIDSLINE MED/99070409; Mortola E; Endo Y; Mizuno T; Ohno K; Watari T; Tsujimoto H; Hasegawa A; Department of Veterinary Internal Medicine, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; Interleukin-12 (IL-12) is an important cytokine for Th1 response which stimulates the T-cell population to produce cytokines for cellular immunity. Interleukin-10 (IL-10) is a pleiotropic cytokine capable of suppressing cytokine production from macrophages and T-cells and participants in Th2 immune response. The prese
Inhibition of apoptosis and virus replication in feline immunodeficiency virus-infected cells by N-acetylcysteine and ascorbic acid.: J Vet Med Sci. 1998 Nov;60(11):1187-93. Unique Identifier : AIDSLINE MED/99070410; Mortola E; Okuda M; Ohno K; Watari T; Tsujimoto H; Hasegawa A; Department of Veterinary Internal Medicine, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; Infection of feline immunodeficiency virus (FIV) has been shown to induce apoptosis that might be associated with the lymphocyte depletion in the infected cats. To investigate the inhibitory effect of antioxidants on FIV-induced apoptosis, we examined the effect of N-acetylcysteine (NAC) and ascorbic acid (AA) on apop
Seroprevalence and field isolation of bovine immunodeficiency virus.: J Vet Med Sci. 1998 Nov;60(11):1195-202. Unique Identifier : AIDSLINE MED/99070411; Meas S; Kabeya H; Yoshihara S; Ohashi K; Matsuki S; Mikami Y; Sugimoto C; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Japan.; A seroprevalence study of bovine lentivirus, known as bovine immunodeficiency virus (BIV), was conducted in 12 different dairy herds in Hokkaido, where some herds were a high prevalence of bovine leukemia virus (BLV) infection. Amongst 611 cattle, 28.6% of cattle were BLV-seropositive, and 11.7% of cattle were seropos
Seroepidemiological survey of feline retrovirus infections in domestic and leopard cats in northern Vietnam in 1997.: J Vet Med Sci. 1998 Nov;60(11):1273-5. Unique Identifier : AIDSLINE MED/99070426; Miyazawa T; Ikeda Y; Maeda K; Horimoto T; Tohya Y; Mochizuki M; Vu D; Vu GD; Cu DX; Ono K; Takahashi E; Mikami T; Department of Veterinary Microbiology, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; The prevalence of infections with three feline retroviruses (feline immunodeficiency virus (FIV), feline leukemia virus (FeLV) and feline syncytial virus (FSV)) was examined in northern Vietnam in 1997. We collected a total of 77 blood samples from 69 domestic and 8 leopard cats,
Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.: Blood. 1999 Mar 1;93(5):1456-63. Unique Identifier : AIDSLINE MED/99155321; Ito S; Ansari P; Sakatsume M; Dickensheets H; Vazquez N; Donnelly RP; Larner AC; Finbloom DS; Division of Cytokine Biology, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, MD, USA.; Interleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype. Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation. Beca
Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells.: Blood. 1999 Mar 1;93(5):1482-6. Unique Identifier : AIDSLINE MED/99155324; Chauhan D; Bharti A; Raje N; Gustafson E; Pinkus GS; Pinkus JL; Teoh G; Hideshima T; Treon SP; Fingeroth JD; Anderson KC; Department of Adult Oncology, Dana-Farber Cancer Institute and; the Department of Medicine, Harvard Medical School, Brigham and; Womens Hospital, Boston, MA, USA.; Whether Kaposi s sarcoma herpesvirus (KSHV) is associated with multiple myeloma (MM) remains controversial. We assayed for KSHV DNA sequences in long-term bone marrow stromal cells (BMSCs) from 26 patients with MM and 4 normal donors. Polymerase chain reaction (PCR) using primers which amplify a KSHV gene sequence to
Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences.: Blood. 1999 Mar 1;93(5):1487-95. Unique Identifier : AIDSLINE MED/99155325; Raje N; Gong J; Chauhan D; Teoh G; Avigan D; Wu Z; Chen D; Treon SP; Webb IJ; Kufe DW; Anderson KC; Department of Adult Oncology, Dana-Farber Cancer Institute,; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Multiple myeloma (MM) cells express idiotypic proteins and other tumor-associated antigens which make them ideal targets for novel immunotherapeutic approaches. However, recent reports show the presence of Kaposi s sarcoma herpesvirus (KSHV) gene sequences in bone marrow dendritic cells (BMDCs) in MM, raising concerns
Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome.: Blood. 1999 Mar 1;93(5):1506-10. Unique Identifier : AIDSLINE MED/99155328; Tan R; Xu X; Ogg GS; Hansasuta P; Dong T; Rostron T; Luzzi G; Conlon CP; Screaton GR; McMichael AJ; Rowland-Jones S; Molecular Immunology Group, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, UK.; Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) probably play the major role in controlling HIV replication. However, the value of adoptive transfer of HIV-specific CTL expanded in vitro to HIV+ patients has been limited: this contrasts with the success of CTL therapy in treating or preventin
Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis.: Blood. 1999 Mar 1;93(5):1511-23. Unique Identifier : AIDSLINE MED/99155329; Riviere C; Subra F; Cohen-Solal K; Cordette-Lagarde V; Letestu R; Auclair C; Vainchenker W; Louache F; INSERM U 362, Institut Gustave Roussy; and CNRS URA 147, Institut; Gustave Roussy, Villejuif, France.; The identification of stromal cell-derived factor (SDF)-1alpha as a chemoattractant for human progenitor cells suggests that this chemokine and its receptor might represent critical determinants for the homing, retention, and exit of precursor cells from hematopoietic organs. In this study, we investigated the express
Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells.: Blood. 1999 Mar 1;93(5):1634-42. Unique Identifier : AIDSLINE MED/99155342; Steinbrink K; Jonuleit H; Muller G; Schuler G; Knop J; Enk AH; Department of Dermatology, University of Mainz, Mainz, Germany;; and the Department of Dermatology, University of Erlangen,; Erlangen, Germany. steinbrink@hautklinik.klinik.uni-mainz.de; Dendritic cells (DC) are critically involved in the initiation of primary immune processes, including tumor rejection. In our study, we investigated the effect of interleukin-10 (IL-10)-treated human DC on the properties of CD8(+) T cells that are known to be essential for the destruction of tumor cells. We show that
Functional Fas-ligand expression on T cells from HIV-1-infected patients is unrelated to CD4+ lymphopenia.: Int J Clin Lab Res. 1998;28(4):215-25. Unique Identifier : AIDSLINE MED/99095567; Silvestris F; Cafforio P; Camarda G; Tucci M; Frassanito MA; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Italy.; Recent studies have demonstrated that the expression of Fas by peripheral T cells from HIV-1+ patients is deregulated and increases the susceptibility of these cells to undergo apoptosis. Here, we show that secretion of Fas-ligand (L), the complementary agonist of Fas, is abnormally upregulated in CD4+ cells from HIV-
Legal trends in bioethics.: J Clin Ethics. 1998 Fall;9(3):323-32. Unique Identifier : AIDSLINE MED/99154095; Davis DS; Forster HP; Cleveland-Marshall College of Law at Cleveland State University,; OH, USA.
Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures.: Mol Biol Cell. 1999 Feb;10(2):313-27. Unique Identifier : AIDSLINE MED/99135881; Rusnati M; Tanghetti E; Urbinati C; Tulipano G; Marchesini S; Ziche M; Presta M; Unit of General Pathology and Immunology, Department of; Biomedical Sciences and Biotechnology, School of Medicine,; University of Brescia, 25123 Brescia, Italy.; Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor-2 (FGF-2), but their mechanism of action has not been elucidated. Here, a possible direct interaction of sialo-glycolipids with FGF-2 has been investigated. Size exclusion chromatography demonstrates that native, but not heat-denatured,
Potential interaction involving warfarin and ritonavir.: Ann Pharmacother. 1998 Dec;32(12):1299-302. Unique Identifier : AIDSLINE MED/99094090; Knoell KR; Young TM; Cousins ES; College of Pharmacy, Ohio State University, Columbus, OH, USA.; OBJECTIVE: To report an unexpected decrease in warfarin effect following the addition of ritonavir to the medication regimen. CASE SUMMARY: A 27-year-old patient with advanced HIV taking warfarin for an inferior vena cava thrombus was started on ritonavir, clarithromycin, and zidovudine. The international normalized r
Successful desensitization to dapsone for Pneumocystis carinii prophylaxis in an HIV-positive patient.: Ann Pharmacother. 1998 Dec;32(12):1302-5. Unique Identifier : AIDSLINE MED/99094091; Cook DE; Kossey JL; Department of Pharmacy Practice, University of Washington School; of Pharmacy, Seattle, USA.; OBJECTIVE: To report a case of successful desensitization to dapsone for Pneumocystis carinii pneumonia (PCP) prophylaxis in a patient unable to tolerate trimethoprim/sulfamethoxazole (TMP/SMX) desensitization or dapsone at standard doses. CASE SUMMARY: A 37-year-old HIV-positive African-American man was treated for p
Protein tyrosine phosphorylation: A possible common signaling pathway in human Th1 and Th2 cell clones.: Int Arch Allergy Immunol. 1999 Jan;118(1):30-6. Unique Identifier : AIDSLINE MED/99126277; Minoguchi K; Yamashita N; Oda N; Takeno M; Kaneoka H; Sakane T; Departments of Immunology and Medicine, St. Marianna University; School of Medicine, Kawasaki, Kanagawa, Japan.; BACKGROUND: It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS: Purified protein derivative-specific
Atypical CD3+ CD4(low) cell population in a boy with fatal EBV-infection.: Int Arch Allergy Immunol. 1999 Jan;118(1):74-8. Unique Identifier : AIDSLINE MED/99126283; Gruber R; Krauss-Etschmann S; Jager G; Belohradsky BH; Koletzko S; Medizinische Poliklinik und Institut fur Immunologie, Munchen,; Deutschland, Germany. Rudolf.Gruber@pk-i.med.uni-muenchen.de; A previously healthy 10-year-old Greek boy born to nonconsanguineous healthy parents developed progressive liver disease after acute infectious mononucleosis. EBV-induced autoimmune hepatitis was suspected and treatment was started with high-dose prednisolone, acyclovir and intr
Reducing HIV transmission [news]: Can Fam Physician. 1999 Feb;45:519-20. Unique Identifier : AIDSLINE MED/99164708; Elliott EB
Former French ministers on trial over blood [news]: BMJ. 1999 Feb 13;318(7181):419. Unique Identifier : AIDSLINE MED/99141105; Dorozynski A
X-rays-induced secretion of cellular factor(s) that enhance(s) HIV-1 promoter transcription in various non-irradiated transfected cell lines.: Cell Mol Biol (Noisy-le-grand). 1998 Dec;44(8):1275-92. Unique Identifier : AIDSLINE MED/99089911; Faure E; UPRES 2202, ICB Case 31, Universite de Provence, Marseille,; France.; Various cellular stress agents like ionizing radiation exposure could activate human immunodeficiency virus type 1 (HIV- 1) replication or reporter gene expression. In addition, extracellular factor(s) released by X-ray-treated human colonic carcinoma cell line (HT29) might activate the long terminal repeat (LTR) of H
Significance of IgA antiphospholipid antibodies.: Unique Identifier : AIDSLINE MED/99029823; Wilson WA; Faghiri Z; Taheri F; Gharavi AE; Department of Medicine, Louisiana State University, New Orleans,; USA. Jbasco@lsumc.edu; IgA anticardiolipin (IgA aCL) and IgA anti beta2-glycoprotein-I (IgA anti beta2GP1) antibodies are common in SLE and have been associated in some studies with thromboses and thrombocytopenia. Experimental work suggests that IgA aCL are as prothrombotic as the IgG-IgM isotypes. However, in SLE there appears to be less
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Dec 18;8(51):357-8. Unique Identifier : AIDSLINE MED/99155828
Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours.: Virchows Arch. 1999 Jan;434(1):11-5. Unique Identifier : AIDSLINE MED/99168787; Herbst H; Kuhler-Obbarius C; Lauke H; Sauter M; Mueller-Lantzsch N; Harms D; Loning T; Institut fur Pathologie, Universitatskrankenhaus Eppendorf,; Hamburg, Germany. herbst@uke.uni-hamburg.de; Gonadoblastomas are rare tumours of abnormal or dysgenetic gonads, often transforming to invasive seminomatous and nonseminomatous germ cell tumours (GCT). Because of the intimate association of noninvasive and invasive lesions, gonadoblastoma may provide clues as to the molecular pathogenesis of GCT. We studied the e
The role of the Epstein-Barr virus in the oncogenesis of EBV(+) gastric carcinomas.: Virchows Arch. 1999 Jan;434(1):17-22. Unique Identifier : AIDSLINE MED/99168788; Takano Y; Kato Y; Saegusa M; Mori S; Shiota M; Masuda M; Mikami T; Okayasu I; Department of Pathology, Kitasato University School of Medicine,; Sagamihara, Kanagawa, Japan.; Five hundred and thirteen cases of gastric carcinoma were investigated for the presence of viral RNA, and the clinico-pathological data, geno-type, BamHIF restriction fragment polymorphism (RFLP) and specific LMP-1 30 bp gene deletion were also examined. EBVs detected in lymphocytes in 20 normal gastric mucosa, 7 lymp
Absence of Kaposi's sarcoma-associated virus (human herpesvirus-8) sequences in angiosarcoma.: Unique Identifier : AIDSLINE MED/99168793; Lasota J; Miettinen M; Kaposi s sarcoma-associated virus (human herpesvirus-8 [HHV8]) sequences have been identified in both AIDS-associated and AIDS-non-associated Kaposi s sarcoma, but data relating to the detection of HHV8 sequences in angiosarcoma are variable. One study showed HHV8 sequences in 29% (7/24) of angiosarcomas, but others h
Human cytomegalovirus infection in foci of Langerhans cell histiocytosis.: Virchows Arch. 1999 Feb;434(2):109-15. Unique Identifier : AIDSLINE MED/99168802; Kawakubo Y; Kishimoto H; Sato Y; Yanagimoto K; Tsuruta T; Ogawa Y; Kameya T; Department of Pathology, School of Nursing, Kitasato University,; Sagamihara, Kanagawa, Japan. kawaaki@nrs.kitasato-u.ac.jp; Langerhans cell histiocytosis (LCH) has been thought to be a disorder of immune regulation, and increasingly, evidence showing that the tissue damage in LCH involves lymphokines and pro-inflammatory cytokines is reported. We detected human cytomegalovirus (HCMV)-DNA in LCH cells in
Neuropathogenesis of HIV-1 infection. Outstanding questions.: C R Acad Sci III. 1998 Dec;321(12):1015-21. Unique Identifier : AIDSLINE MED/99128643; Vitkovic L; Tardieu M; CNRS UPR 9023, centre CNRS-Inserm de pharmacologie et; endocrinologie, Montpellier, France.; Significant progress in understanding and treating acquired immunodeficiency syndrome (AIDS) has been made over the last 5 years. Current multi drug therapies prolong patients lives and reduce the incidence of neurobehavioural symptoms. However, the impact of therapy on human immunodeficiency virus type one (HIV-1),
Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues.: J Recept Signal Transduct Res. 1998 Jul-Nov;18(4-6):321-44. Unique Identifier : AIDSLINE MED/99095114; Frodl R; Gierschik P; Moepps B; Department of Pharmacology and Toxicology, University of Ulm,; Germany.; The human CXC chemokine receptor CXCR4 is activated by stromal cell-derived factor 1. The receptor is present in many cell types and regulates a variety of cellular functions, including chemotaxis, adhesion, hematopoiesis, and organogenesis. Human CXCR4 also serves as a cofactor for cell entry by certain strains of HI
Cardiac autoimmunity in HIV related heart muscle disease.: Heart. 1998 Jun;79(6):599-604. Unique Identifier : AIDSLINE MED/99177815; Currie PF; Goldman JH; Caforio AL; Jacob AJ; Baig MK; Brettle RP; Haven AJ; Boon NA; McKenna WJ; Department of Cardiology, Royal Infirmary of Edinburgh, UK.; OBJECTIVE: To assess the frequency of circulating cardiac specific autoantibodies in HIV positive patients with and without echocardiographic evidence of left ventricular dysfunction. SUBJECTS: 74 HIV positive patients including 28 with echocardiographic evidence of heart muscle disease, 52 HIV negative people at low
German-Austrian Guidelines for HIV-therapy during pregnancy--status: May/June 1998--common statement of the Deutsche AIDS-Gesellschaft (DAIG) and the Osterreichische AIDS-Gesellschaft (OAG).: Eur J Med Res. 1999 Jan 26;4(1):35-42. Unique Identifier : AIDSLINE MED/99111249; Brockmeyer N; Deutsche AIDS-Gesellschaft, Dermatologische Klinik der; Ruhr-Universitat im St. Josef-Hospital, Gudrunstr. 56, D-44791; Bochum, Germany. N.Brockmeyer@derma.de.; The same guidelines are valid for HIV-infected women during pregnancy as for HIV-infected adults. The only modification of these guidelines necessary is that treatment is indicated in clinically asymptomatic pregnant patients when the T-helper cell count is
General paralysis of the insane and AIDS in old age psychiatry: epidemiology, clinical diagnosis, serology and ethics--the way forward.: Int J Geriatr Psychiatry. 1998 Dec;13(12):875-85. Unique Identifier : AIDSLINE MED/99100651; Hilton C; Tameside General Hospital, Ashton Under Lyne, UK.; While the incidence of general paralysis of the insane (GPI) has declined, AIDS (acquired immune deficiency syndrome) has emerged as a new illness. Today, in England and Wales, as many elderly people die from AIDS as from neurosyphilis, although both diagnoses are rare in this age group. Both are serious medical condi
Neuropsychological test performance in the acquired immunodeficiency syndrome: independent effects of diagnostic group on functioning.: J Int Neuropsychol Soc. 1999 Jan;5(1):41-7. Unique Identifier : AIDSLINE MED/99143568; Becker JT; Salthouse TA; Department of Psychiatry, University of Pittsburgh Medical; Center, PA, USA. BeckerJT@MSX.UPMC.EDU; Individuals infected with the acquired immunodeficiency syndrome (AIDS) are at risk for developing cognitive impairment. The extent to which the impairment represents the results of a single factor accounting for a wide degree of cognitive dysfunction, or is the result of the combined effects of multiple factors, has
Riding on a carousel with IFN-alpha and TNF-alpha [editorial; comment]: Ocul Immunol Inflamm. 1998 Dec;6(4):209-10. Unique Identifier : AIDSLINE MED/99122304; Zierhut M
Aging increases CD8 T cell apoptosis induced by hyperstimulation but decreases apoptosis induced by agonist withdrawal in mice.: Cell Immunol. 1999 Feb 1;191(2):131-8. Unique Identifier : AIDSLINE MED/99141162; Telford WG; Miller RA; Department of Pathology, University of Michigan Medical School,; Ann Arbor, Michigan, 48109, USA.; Apoptosis of T cells is thought to play a critical role in intrathymic T cell selection, in controlling the strength of the immune response to antigens, and in peripheral modulation of the T cell repertoire by influencing memory cell formation and survival. Peripheral T lymphocyte apoptosis or activation-induced cell
Seroprevalence of enzootic bovine leukosis in Trakya district (Marmara region) in Turkey.: Prev Vet Med. 1998 Dec 1;37(1-4):121-8. Unique Identifier : AIDSLINE MED/99095659; Uysal A; Yilmaz H; Bilal T; Berriatua E; Bakirel U; Arslan M; Zerin M; Tan H; University of Istanbul, Veterinary Faculty, Department of; Internal Medicine, Avcilar Istanbul, Turkey.; In this study, 481 cattle belonging to 77 farms from nine localities in Trakya district in the Marmara region of Turkey were blood sampled and serologically tested for enzootic bovine leukosis (EBL). Antibodies to bovine leukosis virus (BLV) were detected in 51 cattle sera (11%) be
Seroprevalence to bovine immunodeficiency virus and lack of association with leukocyte counts in Italian dairy cattle.: Prev Vet Med. 1998 Dec 1;37(1-4):147-57. Unique Identifier : AIDSLINE MED/99095661; Cavirani S; Donofrio G; Chiocco D; Foni E; Martelli P; Allegri G; Cabassi CS; De Iaco B; Flammini CF; Istituto di Malattie Infettive, Profilassi e Polizia Veterinaria,; Facolta di Medicina Veterinaria, Universita di Parma, Via del; Taglio, Parma, Italy. martelli@ipruniv.cce.unipr.it; We report herein on the first serological detection of antibodies to bovine immunodeficiency virus (BIV) in Italy . According to criteria of a stratified-random sampling of dairy cattle reared in the Parma area (a province in the Po Valley, Northern Italy), sera from 3166 cows belong
Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection.: J Chromatogr B Biomed Sci Appl. 1998 Nov 20;719(1-2):159-68. Unique Identifier : AIDSLINE MED/99084721; van Heeswijk RP; Hoetelmans RM; Harms R; Meenhorst PL; Mulder JW; Lange JM; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; A reversed-phase high-performance liquid chromatographic assay for the simultaneous quantitative determination of five HIV protease inhibitors (i.e. amprenavir ,
Effects of removal of stratum corneum, delipidization and addition of enhancers, ethanol and l-menthol, on skin permeation of benzoic acid and its 4-n-alkyl substituents in excised guinea pig dorsal skin.: Chem Pharm Bull (Tokyo). 1999 Jan;47(1):44-7. Unique Identifier : AIDSLINE MED/99142313; Kitagawa S; Li H; Niigata College of Pharmacy, Japan.; Skin penetration of benzoic acid and its 4-alkyl substituents (methyl, ethyl, n-propyl and n-butyl) through excised guinea pig dorsal skin was examined, and effects of removal of stratum corneum, delipidization and addition of the penetration enhancers, ethanol and l-menthol plus ethanol, were observed. Permeability c
Activation of a cryptic splice donor in human immunodeficiency virus type-1.: J Biomed Sci. 1999 Jan;6(1):45-52. Unique Identifier : AIDSLINE MED/99134512; Borg KT; Favaro JP; Arrigo SJ; Schmidt M; Department of Microbiology and Immunology, Medical University of; South Carolina, Charleston, S.C., USA.; The human immunodeficiency virus type-1 regulatory protein Rev is absolutely required for the production of viral structural proteins. Splice sites have been seen to function as cis-acting repressor sequendes (CRS) and inhibit expression of the Rev-dependent RNAs. In order to analyze the role of a splice donor in Rev
Antenatal HIV testing. Time for a change in practice.: Pract Midwife. 1998 Jun;1(6):16-9. Unique Identifier : AIDSLINE MED/98406778; Grant J; Roth C; Midwifery Studies, South Bank University.
HIV infection in pregnancy.: Pract Midwife. 1998 Jun;1(6):40-1. Unique Identifier : AIDSLINE MED/98406786; Anderson T; Rosser J
Beta-L-1,3-dioxolane-cytidine: a novel nucleoside that inhibits proliferation and induces differentiation of keratinocytes in vitro.: Skin Pharmacol Appl Skin Physiol. 1998;11(4-5):207-13. Unique Identifier : AIDSLINE MED/99104276; Schwartz PM; Haggerty JG; Cheng YC; Department of Dermatology, Yale University and VA Connecticut; Healthcare System, West Haven, Conn. 06516, USA.; pschwartz@biomed.med.yale.edu; beta-L-1,3-Dioxolane-cytidine (L-(-)-OddC) is a novel L-nucleoside, and its antitumor activity is under investigation in clinical trials. To evaluate the potential of L-(-)-OddC for treating hyperproliferative diseases of the skin, we examined its activity in human keratinocytes in vitro. The dose of L-(-)-OddC that i
Three-dimensional conformation of the epitopes of human superoxide dismutase-2 recognized by antibody against HIV-1p17.: Int J Mol Med. 1998 Jan;1(1):63-6. Unique Identifier : AIDSLINE MED/99074391; Kato T; Daimon M; Suzuki J; Sasaki H; Ishikawa K; Third Department of Internal Medicine, Yamagata University School; of Medicine, Yamagata 990-23, Japan.; We have previously reported that antibodies against HIV-1p17 protein cross-react with human superoxide dismutase-2 (SOD-2). To identify and characterize the epitopes of human SOD-2 recognized by anti-HIV-1p17 antibody, we synthesized several peptide fragments of human SOD-2 and found that the antibody did not bind to
Correlation of activated monocytes or B cells with T lymphocyte subsets in patients with Graves' disease.: Int J Mol Med. 1998 Jan;1(1):95-103. Unique Identifier : AIDSLINE MED/99074397; Gonzalez A; Calleja A; Santiago E; De Miguel C; Lopez-Zabalza MJ; Lopez-Moratalla N; Department of Biochemistry, University of Navarra, Pamplona,; Spain.; We analyzed the phenotypic characteristics of PBMC from 34 patients with Graves disease (GD) at different stages of the disease to explore the sequence of immunological events associated with it. In all cases their monocytes were in a state of activation and differentiation more advanced than those of a group of 23 h
X-linked lymphoproliferative disease: pathology and diagnosis.: Pediatr Dev Pathol. 1999 Jan-Feb;2(1):72-7. Unique Identifier : AIDSLINE MED/99142276; Maia DM; Garwacki CP; Department of Pathology, University of North Carolina School of; Medicine, Chapel Hill 27599-7525, USA.; X-linked lymphoproliferative disease (XLP) is a rare familial disorder resulting in selective immunodeficiency to the Epstein-Barr virus (EBV), characterized by uncontrolled proliferation of EBV-infected lymphocytes. Phenotypes of this disease are variable and include fulminant infectious mononucleosis, hypogammaglobu
Therapy planning as constraint satisfaction: a computer-based antiretroviral therapy advisor for the management of HIV.: Proc AMIA Symp. 1998;:627-31. Unique Identifier : AIDSLINE MED/99123200; Smith DS; Park JY; Musen MA; Division of Infectious Diseases and Geographic Medicine, Stanford; University School of Medicine, CA, USA.; We applied the Protege methodology for building knowledge-based systems to the domain of antiretroviral therapy. We modeled the task of prescribing drug therapy for HIV, abstracting the essential characteristics of the problem solving. We mapped our model of the antiretroviral-therapy domain to the class of constraint
Integrating molecular diagnostic and flow cytometric reporting for improved longitudinal monitoring of HIV patients.: Proc AMIA Symp. 1998;:952-6. Unique Identifier : AIDSLINE MED/99123264; Asare AL; Huda H; Klimczak JC; Caldwell CW; Department of Health Management & Informatics, University of; Missouri-Columbia, School of Medicine, USA.; Studies have shown that monitoring HIV-infected patients undergoing antiretroviral therapy is best represented by combined measurement of plasma HIV-1 RNA and CD4+ T-lymphocytes [1]. This pilot study at the University of Missouri-Columbia integrates molecular diagnostic and flow cytometric data reporting to provide cu
Acute renal failure in a patient with AIDS: histoplasmosis-induced granulomatous interstitial nephritis.: Am J Kidney Dis. 1998 Jul;32(2):E3. Unique Identifier : AIDSLINE MED/99175407; Ahuja TS; Remmers A; Rajaraman S; Funtanilla M; Department of Medicine, University of Texas Medical Branch at; Galveston, Galveston, TX 77555, USA. tahuja@utmb.edu; Although the most frequent cause of acute renal failure (ARF) in patients with AIDS is acute tubular necrosis (ATN) secondary to ischemic renal injury from septicemia, a spectrum of causes may result in ARF in these patients. We report a patient with AIDS who developed ARF and was found to have granulomatous interstit
Epidemiological aspects of Fournier's gangrene at Kenyatta National Hospital, Nairobi.: East Afr Med J. 1998 Oct;75(10):586-9. Unique Identifier : AIDSLINE MED/99164587; Ayumba BR; Magoha GA; Department of Surgery, College of Health Sciences, University of; Nairobi.; This was a retrospective epidemiological study of 171 patients with scrotal (Fournier s gangrene) at Kenyatta National Hospital over eleven year period. The age range was 11 days to 90 years with a mean of 35.38 years. This is different from other reports of a mean of 40.6 years in the older literature and a mean of 5
Perception of risk, sexual behaviour and STD/HIV prevalence in western Kenya.: East Afr Med J. 1998 Dec;75(12):679-83. Unique Identifier : AIDSLINE MED/99164598; Wools KK; Menya D; Muli F; Heilman D; Jones R; Indiana University of School of Medicine, Indianapolis 46202,; USA.; OBJECTIVE: To determine the feasibility and acceptability of collecting data on sexual practices, knowledge, attitudes and perception of risk with regard to HIV and STD infection in two clinic populations. DESIGN: A cross sectional survey carried out between June and July 1992. SETTING: An urban and a rural health cen
Situation analysis of HIV/AIDS epidemic in sub-Saharan Africa.: East Afr Med J. 1998 Dec;75(12):684-6. Unique Identifier : AIDSLINE MED/99164599; Balint GA; Department of Psychiatry, Albert Szent-Gyorgyi Medical; University, Szeged, Hungary.; At the end of 1997 about twenty one million persons were living with HIV/AIDS in sub-Saharan Africa, representing almost two third of the world s total. Three broadly defined areas, which include countries with severe epidemics and others with epidemics at their intermediate stage, account for almost 90% of all curren
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.: EMBO J. 1999 Jan 15;18(2):420-32. Unique Identifier : AIDSLINE MED/99107758; Li B; Tournier C; Davis RJ; Flavell RA; Howard Hughes Medical Institute, Section of Immunobiology, Yale; University School of Medicine, New Haven CT 06520, USA.; The molecular basis for restricted cytokine expression by T helper 1 (Th1) and T helper 2 (Th2) cells is unclear. Previous studies found that P1, an element of the interleukin 4 (IL-4) promoter that binds AP-1, is important for Th2-restricted IL-4 expression. Here we show that JunB, but not the other Jun family member
Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.: EMBO J. 1999 Feb 1;18(3):644-53. Unique Identifier : AIDSLINE MED/99126367; Ellis M; Chew YP; Fallis L; Freddersdorf S; Boshoff C; Weiss RA; Lu X; Mittnacht S; Institute of Cancer Research, Chester Beatty Laboratory, London,; UK.; The Kaposi s sarcoma-associated human herpesvirus 8 (KSHV/HHV8) encodes a protein similar to cellular cyclins. This cyclin is most closely related to cellular D-type cyclins, but biochemically it behaves atypically in various respects. Complexes formed between the viral cyclin and the cyclin-dependent kinase subunit,
Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus.: EMBO J. 1999 Feb 1;18(3):654-63. Unique Identifier : AIDSLINE MED/99126368; Mann DJ; Child ES; Swanton C; Laman H; Jones N; Department of Biology and Biochemistry, Brunel University,; Uxbridge, Middlesex, UB8 3PX. David.Mann@brunel.ac.uk; DNA tumour viruses have evolved a number of mechanisms by which they deregulate normal cellular growth control. We have recently described the properties of a cyclin encoded by human herpesvirus 8 (also known as Kaposi s sarcoma-associated herpesvirus) which is able to resist the actions of p16(Ink4a), p21(Cip1) and p
Lipid A directly inhibits IL-4 production by murine Th2 cells but does not inhibit IFN-gamma production by Th1 cells.: Eur J Immunol. 1999 Feb;29(2):413-8. Unique Identifier : AIDSLINE MED/99161819; Watanabe T; Inoue T; Ochi H; Terashima M; Asano Y; Nakatani T; Sumitomo Pharmaceuticals Research Center, Osaka, Japan.; twatanab@sumitomopharm.co.jp; Lipopolysaccharide (LPS) is known to be an immunopotentiator but its effect on cytokine production by Th1 and Th2 cells is unknown. We found that high amounts of LPS, its lipid A moiety, and a lipid A analog all induced a decrease in IL-4 production and an increase in IFN-gamma production when given to keyhole limpet
Induction of interferon-gamma production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation.: Eur J Immunol. 1999 Feb;29(2):548-55. Unique Identifier : AIDSLINE MED/99161833; Yang J; Murphy TL; Ouyang W; Murphy KM; Department of Pathology and Center for Immunology, Howard Hughes; Medical Institute, Washington University School of Medicine, St.; Louis, MO 63110, USA.; IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but here we analyze a second, antigen-nonspecific pathway capable of inducing full IFN-gamma transcription. IL-12 or IL-18 alone do not ind
CD40-deficient mice infected with the defective murine leukemia virus LP-BM5def do not develop murine AIDS but produce IgE and IgG1 in vivo.: Eur J Immunol. 1999 Feb;29(2):615-25. Unique Identifier : AIDSLINE MED/99161841; Yu P; Morawetz RA; Chattopadhyay S; Makino M; Kishimoto T; Kikutani H; Research Institute for Microbial Diseases, Osaka University,; Suita, Japan.; CD40-deficient mice, when inoculated with the LP-BM5def murine retorvirus, become infected and show virus expression similar to wild-type mice. However, unlike the wild-type mice, CD40-deficient mice do not develop symptoms of immunodeficiency, lymphoproliferative disease and the typical histological changes in the ly
Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells.: Unique Identifier : AIDSLINE MED/99161847; Suri-Payer E; Amar AZ; McHugh R; Natarajan K; Margulies DH; Shevach EM; Cellular Immunology Section, Laboratory of Immunology, NIAID,; NIH, Bethesda 20892-1892, USA.; Thymectomy at day 3 of life (d3Tx) results in the development of organ-specific autoimmunity. We have recently shown that d3Tx BALB/c mice which develop autoimmune gastritis contain CD4+ T cells specific for the gastric parietal cell proton pump, H/K ATPase. Here, we demonstrate that freshly explanted gastric lymph no
Apoptotic features of peripheral blood granulocytes and monocytes during primary, acute HIV infection.: Unique Identifier : AIDSLINE MED/99159035; Cossarizza A; Mussini C; Borghi V; Mongiardo N; Nuzzo C; Pedrazzi J; Benatti F; Moretti L; Pinti M; Paganelli R; Franceschi C; De Rienzo B; Apoptosis plays a major role during HIV infection, including the primary, acute HIV syndrome (AHS), during which such phenomenon is massive. We asked whether apoptosis involved not only peripheral blood lymphocytes, but also monocytes (PBM) and granulocytes (PBG). Thus, we studied cells from different patients during
Increased condom use among teenage males, 1988-1995: the role of attitudes.: Fam Plann Perspect. 1998 Nov-Dec;30(6):276-80, 303. Unique Identifier : AIDSLINE MED/99076115; Murphy JJ; Boggess S; Population Studies Center, Urban Institute, Washington, DC.; CONTEXT: Understanding whether and to what degree changes in young men s attitudes explain increases in condom use over time can be useful in developing more effective disease prevention strategies. METHODS: Data from the 1988 and the 1995 National Survey of Adolescent Males are used to determine changes in attitudes
Immunological issues in vaccine trials: T-cell responses.: Dev Biol Stand. 1998;95:117-24. Unique Identifier : AIDSLINE MED/99071063; Kourilsky P; Bousso P; Calbo S; Gapin L; Laboratoire de Biologie Moleculaire du Gene, Institut Pasteur,; Paris, France.; T-cell responses are both extremely diverse and dependent on the MHC of the immunized (or infected) individual. Apart from T-cell proliferation assays, the most informative functional T-cell assays are still difficult to perform. Antibody measurements provide a very indirect assessment of the helper arm of the T-cell
HIV-1 DNA based vaccine induces a CD8 mediated cross-clade CTL response.: Dev Biol Stand. 1998;95:147-53. Unique Identifier : AIDSLINE MED/99071067; Boyer JD; Chattergoon M; Shah A; Ginsberg R; MacGregor RR; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.; Novel approaches for the generation of more effective vaccines for HIV-1 are of significant importance. In this report we analyse the immunogenicity and efficacy of a DNA vaccination approach in a chimpanzee model system. Three chimpanzees were vaccinated with DNA constructs which express the env, rev, gag and pol pro
Assessment of human CD4+ and CD8+ T lymphocyte responses in experimental viral vaccine studies.: Dev Biol Stand. 1998;95:95-104. Unique Identifier : AIDSLINE MED/99071061; Rothman AL; Yamada Y; Jameson J; Cruz J; West K; Green S; Ennis FA; Center for Infectious Diseases and Vaccine Research, University; of Massachusetts Medical Center, Worcester 01655, USA.; The traditional in vitro correlate of immunological protection is the induction by a vaccine of neutralizing antibodies against the virus. It was formerly assumed that protection induced by a vaccine was solely due to neutralizing antibodies. Neutralizing antibodies are potent in the prevention of certain diseases, bu
Acute lower intestinal bleeding. Part II: etiology, therapy, and outcomes.: Gastrointest Endosc. 1999 Feb;49(2):228-38. Unique Identifier : AIDSLINE MED/99124666; Zuckerman GR; Prakash C; Division of Gastroenterology, Washington University School of; Medicine, St. Louis, Missouri, USA.
A G to A transition at the last nucleotide of exon 6 of the gamma c gene (868G-->A) may result in either a splice or missense mutation in patients with X-linked severe combined immunodeficiency.: Hum Genet. 1999 Jan;104(1):36-42. Unique Identifier : AIDSLINE MED/99168748; Kanai N; Yanai F; Hirose S; Nibu K; Izuhara K; Tani T; Kubota T; Mitsudome A; Department of Pediatrics, School of Medicine, Fukuoka University,; Japan.; We report here that a defect of the interleukin common gamma subunit (gamma c) in X-linked severe combined immunodeficiency (XSCID) previously known as a missense mutation resulted instead in exon skipping in a Japanese XSCID patient. The phenotype of the patient was consistent with that of typical XSCID, and his Epst
Generation of CD8(+) T-cell responses to Mycobacterium bovis and mycobacterial antigen in experimental bovine tuberculosis.: Infect Immun. 1999 Mar;67(3):1034-44. Unique Identifier : AIDSLINE MED/99150230; Liebana E; Girvin RM; Welsh M; Neill SD; Pollock JM; Department of Veterinary Science, Queen's University of Belfast,; Stormont, Belfast, Northern Ireland.; Protective immunity against tuberculosis is considered to be essentially cell mediated, and an important role for CD8(+) T lymphocytes has been suggested by several studies of murine and human infections. The present work, using an experimental model of infection with Mycobacterium bovis in cattle, showed that live M.
Enhanced Th1 and dampened Th2 responses synergize to inhibit acute granulomatous and fibrotic responses in murine schistosomiasis mansoni.: Infect Immun. 1999 Mar;67(3):1187-93. Unique Identifier : AIDSLINE MED/99150249; Boros DL; Whitfield JR; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201, USA.; dboros@med.wayne.edu; In murine schistosomiasis mansoni, CD4(+) Th1 and Th2 cells participate in the ovum-induced granulomatous inflammation. Previous studies showed that the interleukin-12 (IL-12)-induced Th1 response strongly suppressed the Th2-cell-mediated pulmonary granuloma development in naive or primed mice. However, liver granulom
Dysregulated production of interleukin-8 in individuals infected with human immunodeficiency virus type 1 and Mycobacterium tuberculosis.: Infect Immun. 1999 Mar;67(3):1251-60. Unique Identifier : AIDSLINE MED/99150258; Meddows-Taylor S; Martin DJ; Tiemessen CT; MRC AIDS Virus Research Unit, National Institute for Virology,; and Department of Virology, University of the Witwatersrand,; Johannesburg, South Africa.; Interleukin-8 (IL-8) production in vivo was monitored in four study groups: normal blood donors, patients with pulmonary tuberculosis (TB), patients with human immunodeficiency virus type 1 (HIV-1) infection, and dually infected (HIV/TB) patients. We show that whereas there was evidence of detectable levels of cell-as
Effect of d-fenfluramine on the lymphocyte response of HIV+ humans.: Int J Immunopharmacol. 1998 Dec;20(12):751-63. Unique Identifier : AIDSLINE MED/99093112; Mathews HL; Goral J; Yamamura Y; Clancy J; Lorens SA; Department of Microbiology and Immunology, Stritch School of; Medicine, Loyola University of Chicago, Maywood, IL 60153, USA.; The objective of this study was to analyse the effect of d-dexfenfluramine (d-FEN) on the human lymphocyte response, in vitro. Experiments were designed to determine whether d-FEN augments specific human immune parameters associated with protection from opportunistic microbial pathogens and particularly focuses on d-F
Retinal microvasculopathy in human immunodeficiency type 1 (HIV)-infected children.: Int Ophthalmol. 1997-98;21(6):319-21. Unique Identifier : AIDSLINE MED/99084684; Tejada P; Sarmiento B; Ramos JR; Department of Ophthalmology, Hospital Doce de Octubre, Madrid,; Spain.; PURPOSE: To report two cases of retinal peripheral lesions in vertically HIV-infected children. METHODS: Complete ophthalmological examinations were performed in both cases over a period of four years. RESULTS: We found retinal peripheral lesions in four eyes of two patients who were referred to us for routine examina
The behaviors of AIDS patients toward their nurses.: Int J Nurs Stud. 1998 Dec;35(6):330-8. Unique Identifier : AIDSLINE MED/99088989; Kemppainen JK; O'Brien L; Corpuz B; VA Palo Alto Health Care System, California, USA.; djkemp@ix.netcom.com; The purpose of this study is to identify the behavioral responses of hospitalized patients with HIV/AIDS to nursing care providers. The critical incident technique, developed by Flanagan (1954) was used to obtain a listing of the behavioral responses. Patients were asked to recall brief descriptions of caregiving even
Cloning and functional characterization of the 5'-flanking region of the human monocyte chemoattractant protein-1 receptor (CCR2) gene. Essential role of 5'-untranslated region in tissue-specific expression.: J Biol Chem. 1999 Feb 19;274(8):4646-54. Unique Identifier : AIDSLINE GENBANK/AF068265; Yamamoto K; Takeshima H; Hamada K; Nakao M; Kino T; Nishi T; Kochi M; Kuratsu J; Yoshimura T; Ushio Y; Department of Neurosurgery, Kumamoto University School of; Medicine, Kumamoto 860-8556, Japan.; The human monocyte chemoattractant protein-1 receptor designated hCCR2 is an essential co-receptor in cell entry by the human immunodeficiency virus as well as a receptor for monocyte chemoattractant protein-1, a member of the family of C-C chemokines that mediate monocyte chemotaxis. To elucidate the molecular mechan
Biophysical characterization of the structure of the amino-terminal region of gp41 of HIV-1. Implications on viral fusion mechanism.: J Biol Chem. 1999 Feb 26;274(9):5299-309. Unique Identifier : AIDSLINE MED/99150305; Chang DK; Cheng SF; Trivedi VD; Institute of Chemistry, Academia Sinica, Taipei, 11529 Taiwan,; Republic of China. dkc@chem.sinica.edu.tw; A peptide of 51 amino acids corresponding to the NH2-terminal region (5-55) of the glycoprotein gp41 of human immunodeficiency virus type 1 was synthesized to study its conformation and assembly. Nuclear magnetic resonance experiments indicated the sequence NH2-terminal to the leucine zipper-like domain of gp41 was in
Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain.: J Biol Chem. 1999 Feb 26;274(9):5326-32. Unique Identifier : AIDSLINE MED/99150308; Endrich MM; Gehrig P; Gehring H; Biochemisches Institut, Universitat Zurich, CH-8057 Zurich,; Switzerland.; Viral incorporation of cyclophilin A (CyPA) during the assembly of human immunodeficiency virus type-1 (HIV-1) is crucial for efficient viral replication. CyPA binds to the previously identified Gly-Pro90 site of the capsid protein p24, but its role remained unclear. Here we report two new interaction sites between cy
Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the: Unique Identifier : AIDSLINE MED/99150338
Typing of clinical Mycobacterium avium complex strains cultured during a 2-year period in Denmark by using IS1245.: J Clin Microbiol. 1999 Mar;37(3):600-5. Unique Identifier : AIDSLINE MED/99143217; Bauer J; Andersen AB; Askgaard D; Giese SB; Larsen B; Department of Mycobacteriology, Statens Serum Institut,; Copenhagen, Denmark. jba@ssi.dk; In the present study restriction fragment length polymorphism analyses with the recently described insertion sequence IS1245 as a probe was performed with clinical Mycobacterium avium complex strains cultured in Denmark during a 2-y
Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum Darling.: J Clin Microbiol. 1999 Mar;37(3):653-63. Unique Identifier : AIDSLINE MED/99143226; Kasuga T; Taylor JW; White TJ; Roche Molecular Systems, Alameda, California 94501, USA.; takao.kasuga@roche.com; The phylogeny of 46 geographically diverse Histoplasma capsulatum isolates representing the three varieties capsulatum, duboisii, and farciminosum was evaluated using partial DNA sequences of four protein coding genes. Parsimony and distance analysis of the separate genes were generally congruent and analysis of the c
Detection of the 70-kilodalton histoplasma capsulatum antigen in serum of histoplasmosis patients: correlation between antigenemia and therapy during follow-up.: J Clin Microbiol. 1999 Mar;37(3):675-80. Unique Identifier : AIDSLINE MED/99143228; Gomez BL; Figueroa JI; Hamilton AJ; Diez S; Rojas M; Tobon A; Restrepo A; Hay RJ; Corporacion para Investigaciones Biologicas, A. A. 73-78,; Medellin, Colombia. g.beatriz@UMDS.ac.uk; Histoplasmosis is an important systemic fungal infection, particularly among immunocompromised individuals, who may develop a progressive disseminated form which is often fatal if it is untreated. In such patients, the detection of antibody responses for both diagnosis and follow-up may be of limited use, whereas the
Dual qualitative-quantitative nested PCR for detection of JC virus in cerebrospinal fluid: high potential for evaluation and monitoring of progressive multifocal leukoencephalopathy in AIDS patients receiving highly active antiretroviral therapy.: J Clin Microbiol. 1999 Mar;37(3):724-8. Unique Identifier : AIDSLINE MED/99143238; Garcia de Viedma D; Alonso R; Miralles P; Berenguer J; Rodriguez-Creixems M; Bouza E; Servicio de Microbiologia y Enfermedades Infecciosas-HIV,; Hospital General Universitario "Gregorio Maranon," 28007; Madrid, Spain. dgviedma@microb.net; JC polyomavirus (JCV) is the causative agent of progressive multifocal leukoencephalopathy (PML), a central nervous system infection that mainly affects AIDS patients. The extensive application of highly active antiretroviral therapy (HAART) is leading to the appearance of long-term survival PML patients. A reliable
The IS6110 restriction fragment length polymorphism in particular multidrug-resistant Mycobacterium tuberculosis strains may evolve too fast for reliable use in outbreak investigation.: J Clin Microbiol. 1999 Mar;37(3):788-91. Unique Identifier : AIDSLINE MED/99143253; Alito A; Morcillo N; Scipioni S; Dolmann A; Romano MI; Cataldi A; van Soolingen D; Pathobiology Institute CICV/INTA, Moron, Argentina.; To study possible nosocomial transmission of multidrug-resistant (MDR) Mycobacterium tuberculosis, strain types and other information on 24, mostly human immunodeficiency virus-positive patients, were collected. Isolates from 11 patients had identical IS6110 restriction fragment length polymorphism (RFLP) patterns as
Evaluation of the ultrasensitive Roche Amplicor HIV-1 monitor assay for quantitation of human immunodeficiency virus type 1 RNA.: J Clin Microbiol. 1999 Mar;37(3):792-5. Unique Identifier : AIDSLINE MED/99143254; Erali M; Hillyard DR; ARUP Institute for Clinical and Experimental Pathology,; University of Utah Health Sciences Center, Salt Lake City, Utah; 84108, USA.; The ultrasensitive Amplicor HIV-1 Monitor test (Roche Diagnostic Systems) was evaluated for precision, linearity, and sensitivity and was compared to the standard Amplicor assay. The ultrasensitive assay reliably quantified samples in the range from 50 to 50,000 human immunodeficiency virus type 1 RNA copies/ml with a
Application of dried blood spot specimens for serologic subtyping of human immunodeficiency virus type 1 in Thailand.: J Clin Microbiol. 1999 Mar;37(3):804-6. Unique Identifier : AIDSLINE MED/99143258; Chanbancherd P; Brown AE; Trichavaroj R; Tienamporn P; Puthakird P; Limpairojn N; VanCott TC; de Souza MS; Army Institute of Pathology, Bangkok, Thailand.; Dried blood spot (DBS) specimens were assessed as an alternative to plasma for human immunodeficiency virus type 1 (HIV-1) serotyping by V3 loop peptide enzyme immunoassay. Nested PCR capable of distinguishing HIV-1 subtypes B and E was used as the reference standard. Ninety-two percent of DBS samples were typeable as
Reproducibility and performance of the second-generation branched-DNA assay in routine quantification of human immunodeficiency virus type 1 RNA in plasma.: Unique Identifier : AIDSLINE MED/99143260; Murphy DG; Gonin P; Fauvel M; We examined the reproducibility of a second-generation branched-DNA (bDNA) assay (Quantiplex HIV RNA 2.0) for quantification of human immunodeficiency virus type 1 (HIV-1) RNA in plasma by retesting 325 specimens on separate runs and on different lots. The performance of the bDNA test was also assessed by data analysi
Evaluation of the fungitest kit by using strains from human immunodeficiency virus-infected patients: study of azole drug susceptibility.: J Clin Microbiol. 1999 Mar;37(3):864-6. Unique Identifier : AIDSLINE MED/99143276; Witthuhn F; Toubas D; Beguinot I; Aubert D; Rouger C; Remy G; Pinon JM; Laboratoire de Parasitologie-Mycologie, Equipe 4 INSERM U 314, EA; 2070, IFR 53, Centre Hospitalier Universitaire de Reims, France.; One hundred eighteen Candida clinical isolates from human immunodeficiency virus-infected patients were tested for their susceptibilities to fluconazole and itraconazole by Fungitest and the National Committee for Clinical Laboratory Standards MIC method. Fungitest results depended on both yeast species and antifungal
In vitro susceptibilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents.: J Clin Microbiol. 1999 Mar;37(3):870-2. Unique Identifier : AIDSLINE MED/99143278; Pfaller MA; Messer SA; Gee S; Joly S; Pujol C; Sullivan DJ; Coleman DC; Soll DR; Departments of Pathology, University of Iowa, Iowa City, Iowa,; USA. michael-pfaller@uiowa.edu; Candida dubliniensis is a newly recognized fungal pathogen causing mucosal disease in AIDS patients. Although preliminary studies indicate that most strains of C. dubliniensis are susceptible to established antifungal agents, fluconazole-resistant strains have been detected. Furthermore, fluconazole-resistant strains
Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients.: J Clin Pathol. 1998 Dec;51(12):914-21. Unique Identifier : AIDSLINE MED/99169486; Evans PC; Soin A; Wreghitt TG; Alexander GJ; Department of Medicine, University of Cambridge School of; Clinical Medicine, Addenbrooke's NHS Trust, UK.; AIM: To identify cytomegalovirus ( CMV ) infection in liver transplant recipients by polymerase chain reaction (PCR) techniques and to separate the cases in which CMV related disease will occur, for whom treatment is indicated,
Differential expression of interferon gamma by mitogen-stimulated peripheral blood mononuclear cells among Kuwaiti psoriasis patients.: J Dermatol. 1999 Jan;26(1):23-8. Unique Identifier : AIDSLINE MED/99162695; Mahmoud F; Abul H; al-Seleh Q; Morgan G; Haines D; al-Ramly M; Burleson J; Kreutzer D; Department of Medical Laboratory Sciences, Faculty of Allied; Health Sciences and Nursing, Kuwait University, Sulaibekhat,; Kuwait.; Most diseases exhibit characteristic profiles of cytokine expression, broadly subdivided into Th1, involving primarily cell-mediated responses, of which Interferon-gamma (INF-gamma), Interleukin-2 ( IL-2 ) and Tumor Necrosis Factor-alpha (TNF-alpha) are hallmarks, and Th
Nurses intensify world-wide efforts to ensure HIV/AIDS care for all [news]: J Adv Nurs. 1998 Dec;28(6):1177. Unique Identifier : AIDSLINE MED/99103434
'What drugs could I give my child?' [news]: J Adv Nurs. 1998 Dec;28(6):1180. Unique Identifier : AIDSLINE MED/99103435
Transcending the physical: spiritual aspects of pain in patients with HIV and/or cancer.: J Adv Nurs. 1998 Dec;28(6):1236-41. Unique Identifier : AIDSLINE MED/99103443; Newshan G; Section of HIV Medicine, St. Vincent's Hospital, New York, New; York, USA.; Spirituality is an important though often neglected aspect of pain in patients with human immunodeficiency virus (HIV) and/or cancer, for both patients and nurses. The spiritual domain involves: (1) meaning, (2) hope and (3) love and relatedness. The author examines spiritual aspects of pain in persons with HIV and/or
Cryptosporidium and HIV.: J Indian Med Assoc. 1998 Sep;96(9):276-7. Unique Identifier : AIDSLINE MED/99162770; Agarwal A; Ningthouja S; Sharma D; Mohen Y; Singh NB; ICMR Unit for Research on AIDS in North-eastern States of India,; R&D Wing, Lamphelpat, Imphal.; To study the importance of cryptosporidium as a diarrhoea causing pathogen (using stool samples), a cohort study was conducted from 14-9-1994 to 14-3-1995 on injecting drug users in Imphal. Stool samples were also collected from close contacts of the patients of human immunodeficiency virus (HIV) infected cryptosporid
HIV infection among dental patients.: J Indian Med Assoc. 1998 Sep;96(9):278. Unique Identifier : AIDSLINE MED/99162771; Lakshmi N; Kumar AG; Subbarayudu S; Rao BS; Department of Microbiology, SV Medical College, Tirupati.; Oral manifestations may be the important indicators of ongoing human immunodeficiency virus (HIV) infection. Serum samples were collected from 100 patients repeatedly attending dental outpatients department of SV Medical College and SVRR Hospital, Tirupati and tested for the presence of HIV antibodies. HIV 1 antibodi
Paediatric HIV infection: a brief review.: J Indian Med Assoc. 1998 Sep;96(9):279-81. Unique Identifier : AIDSLINE MED/99162772; Bhattacharya MK; Teka T; Fuchs G; Clinical Sciences Division, International Centre for Diarrhoeal; Disease Research, Bangladesh (ICDDR, B), Dhaka.
Elevated concentrations of plasma alpha-melanocyte stimulating hormone are associated with reduced disease progression in HIV-infected patients.: J Lab Clin Med. 1999 Mar;133(3):309-15. Unique Identifier : AIDSLINE MED/99170479; Airaghi L; Capra R; Pravettoni G; Maggiolo F; Suter F; Lipton JM; Catania A; Third Division of Internal Medicine, Ospedale Maggiore di Milano; IRCCS, Italy.; To determine whether concentrations of the anti-inflammatory peptide alpha-melanocyte stimulating hormone (alpha-MSH) are associated with accelerated or reduced disease progression in patients with HIV infection, plasma concentrations of alpha-MSH and two other anticytokine molecules, interleukin-1 receptor antagonist
CD4+ and CD8+ lymphocyte and cortisol response patterns in elderly and young males after methylprednisolone exposure.: Unique Identifier : AIDSLINE MED/99081054; Tornatore KM; Venuto RC; Logue G; Davis PJ; The elderly have impaired cellular immunity and are more predisposed to opportunistic infections after long term glucocorticoid treatment. No data, examining the response of
Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide.: J Neurochem. 1999 Mar;72(3):1283-93. Unique Identifier : AIDSLINE MED/99155106; Bassan M; Zamostiano R; Davidson A; Pinhasov A; Giladi E; Perl O; Bassan H; Blat C; Gibney G; Glazner G; Brenneman DE; Gozes I; Department of Clinical Biochemistry, Sackler School of Medicine,; Tel Aviv University, Israel.; The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective compounds fundamentally important. Here, the complete coding sequence of a novel protein (828 amino acids, pI 5.99), derived from mouse neuroglial cells, is revealed. The sequence contained (1) a neuroprotective peptide, N
Cancer vaccines.: J Clin Oncol. 1999 Mar;17(3):1047-60. Unique Identifier : AIDSLINE MED/99168858; Greten TF; Jaffee EM; Department of Oncology, The Johns Hopkins University School of; Medicine, Baltimore, MD 21205-2196, USA.; It has been more than 100 years since the first reported attempts to activate a patient s immune system to eradicate developing cancers. Although a few of the subsequent vaccine studies demonstrated clinically significant treatment effects, active immunotherapy has not yet become an established cancer treatment modali
Oral mucosal leishmaniasis as a presenting feature of HIV infection and its management.: J Oral Pathol Med. 1999 Jan;28(1):43-6. Unique Identifier : AIDSLINE MED/99105463; Chaudhry Z; Barrett AW; Corbett E; French PD; Zakrzewska JM; Department of Oral Medicine, Eastman Dental Institute and; Hospital for Oral Healthcare Sciences, London, England.; Leishmaniasis is a chronic parasitic protozoal disease transmitted by sandfly vectors and is endemic in some regions of South America, Asia, Africa and Mediterranean countries. This case report describes a British patient who presented with oral mucosal leishmaniasis and in whom it was also the first sign of HIV disea
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.: J Med Chem. 1999 Feb 11;42(3):393-9. Unique Identifier : AIDSLINE MED/99143287; Siddiqui AQ; Ballatore C; McGuigan C; De Clercq E; Balzarini J; Welsh School of Pharmacy, University of Wales Cardiff, King; Edward VII Avenue, Cardiff CF1 3XF, U.K.; New substituted-aryl phosphoramidate derivatives of the anti-HIV drug d4T were synthesized as membrane-soluble intracellular prodrugs for the free bioactive phosphate to establish relationship(s) between compound structure and in vitro antiviral activ
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.: J Med Chem. 1999 Feb 11;42(3):497-509. Unique Identifier : AIDSLINE MED/99143298; King PJ; Ma G; Miao W; Jia Q; McDougall BR; Reinecke MG; Cornell C; Kuan J; Kim TR; Robinson WE Jr; Department of Microbiology and Molecular Genetics, University of; California, Irvine, California 92697-4800, USA.; The dicaffeoylquinic acids (DCQAs) and dicaffeoyltartaric acids (DCTAs) are potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase. They also inhibit HIV-1 replication at nontoxic concentrations. Since integrase is an excellent target for anti-HIV therapy, structure-activity relations
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.: J Med Chem. 1999 Feb 25;42(4):584-92. Unique Identifier : AIDSLINE MED/99162433; Moreau P; Anizon F; Sancelme M; Prudhomme M; Bailly C; Severe D; Riou JF; Fabbro D; Meyer T; Aubertin AM; Universite Blaise Pascal, Synthese Electrosynthese et Etude de; Systemes a Interet Biologique, UMR 6504 du CNRS, 63177; Aubiere, France.; In the course of structure-activity relationships on rebeccamycin analogues, a series of compounds bearing a halogenoacetyl substituent were synthesized with the expectation of increasing the interaction with DNA, possibly via covalent reaction with the double helix. Two rebeccamycin analogues bearing an acetyl instea
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.: J Med Chem. 1999 Feb 25;42(4):619-27. Unique Identifier : AIDSLINE MED/99162437; Mai A; Artico M; Sbardella G; Massa S; Novellino E; Greco G; Loi AG; Tramontano E; Marongiu ME; La Colla P; Dipartimento di Studi Farmaceutici, Istituto Pasteur-Fondazione; Cenci Bolognetti, Universita degli Studi di Roma "La Sapienza",; P. le A. Moro 5, I-00185 Roma, Italy.; Molecular modeling analysis of compounds belonging to the recently published series of dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S-DABOs and DATNOs, gave support to the design of new 2, 6-disubstituted benzyl-DABO derivatives as highly potent and specific inhibitors of the HIV-1 reverse transcriptase (RT).
SIVmac vaccine studies using whole inactivated virus antigen sequentially depleted of viral proteins.: J Med Primatol. 1998 Aug;27(4):184-92. Unique Identifier : AIDSLINE MED/99094468; Norley S; Beer B; Konig H; Jensen F; Kurth R; Paul-Ehrlich-Institute, Langen, Germany.; Groups of four rhesus monkeys were immunised at 0, 1, 2, and 13 months with whole inactivated SIVmac32H, SIVmac depleted of the outer envelope glycoprotein gp130, virus cores depleted of the lipid membrane (and hence transmembrane glycoproteins), or purified gag protein. These macaques plus controls were challenged wi
CD4/GP120mac251 interaction induces phospholipase A2 (PLA2) activation in cynomolgus monkey lymphocytes.: J Med Primatol. 1998 Aug;27(4):193-201. Unique Identifier : AIDSLINE MED/99094469; Mavoungou E; Poaty-Mavoungou V; Unit of Immunology, International Center for Medical Research,; Franceville (CIRMF), Gabon. emavoung@cirmfrv.fr; Cynomolgus monkey are susceptible to infection with select simian immunodeficiency virus (SIV). We investigated the early interactions between SIV envelope glycoproteins (gp120mac251) and macaque lymphocytes. Our results demonstrate that the soluble viral glycoprotein induce a specific phospholipase A2 (PLA2) activati
Peptide immunization restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes in cynomolgus monkeys.: J Med Primatol. 1998 Aug;27(4):202-9. Unique Identifier : AIDSLINE MED/99094470; Mavoungou E; Toure FS; Yaba P; Delicat A; Poaty-Mavoungou V; Unit of Immunology, International Center for Medical Research,; Franceville, (CIRMF), Gabon. emavoung@cirmfrv.fr; A potential strategy to induce peptide specific CTL in vivo was investigated. A synthetic vaccine consisting of an SIV-derived, HLA-A2. 1-binding CTL epitope and a tetanus toxin-derived T helper epitope was evaluated for its capacity to induce peptide-specific CTL in monkeys. Thirteen animals were immunized and booste
Collective motions in HIV-1 reverse transcriptase: examination of flexibility and enzyme function.: J Mol Biol. 1999 Jan 22;285(3):1023-37. Unique Identifier : AIDSLINE MED/99141361; Bahar I; Erman B; Jernigan RL; Atilgan AR; Covell DG; National Institutes of Health, Bethesda, MD, 20892-5677, USA.; In order to study the inferences of structure for mechanism, the collective motions of the retroviral reverse transcriptase HIV-1 RT (RT) are examined using the Gaussian network model (GNM) of proteins. This model is particularly suitable for elucidating the global dynamic characteristics of large proteins such as the
Antisense-mediated repression of DNA topoisomerase II expression leads to an impairment of HIV-1 replicative cycle.: J Mol Biol. 1999 Jan 22;285(3):945-54. Unique Identifier : AIDSLINE MED/99141355; Bouille P; Subra F; Mouscadet JF; Auclair C; Laboratoire de Pharmacologie des Macromolecules Biologiques,; CNRS UMR 1772, Institut Gustave Roussy, Villejuif, France.; pbouille@igr.fr; Previously, we have observed a strong restriction of the Moloney murine leukemia virus (MoMLV) replicative cycle in a cell line displaying resistance to topoisomerase II (topo II)-interactive drugs. Resistance towards these antitumoral inhibitors was associated with decreased expression and activity of topo II, sugges
Compression of the DNA minor groove is responsible for termination of DNA synthesis by HIV-1 reverse transcriptase.: J Mol Biol. 1999 Jan 22;285(3):977-95. Unique Identifier : AIDSLINE MED/99141358; Lavigne M; Buc H; Unite de Physicochimie des Macromolecules Biologiques (CNRS URA; 1773), Institut Pasteur, 75724 Paris Cedex 15, France.; mlavigne@pasteur.fr; HIV-1 reverse transcriptase (RT) generally terminates plus strand DNA synthesis at the centre of the viral genome. The central termination sequence (CTS) contains two termination sites which are located at the 3 end of AnTm motifs. These motifs generate a global curvature of the DNA helix which correlates with termin
High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: evidence of nonsexual transmission.: J Natl Cancer Inst. 1999 Mar 3;91(5):465-9. Unique Identifier : AIDSLINE MED/99168495; Andreoni M; El-Sawaf G; Rezza G; Ensoli B; Nicastri E; Ventura L; Ercoli L; Sarmati L; Rocchi G; Infectious Diseases Institute, University of Tor Vergata, Rome,; Italy. andreoni@uniroma2.it; BACKGROUND: In western countries, human herpesvirus-8 (HHV-8) appears to be transmitted mainly by sexual contact. To evaluate the role of other transmission routes, especially in developing countries, we estimated the seroprevalence of HHV-8 in Egyptian children, who, if seropositive, would have acquired the virus thr
Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation.: J Neurosci Res. 1999 Jan 1;55(1):127-34. Unique Identifier : AIDSLINE MED/99105447; Carson MJ; Sutcliffe JG; Campbell IL; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.; A major question relevant to the initiation and progression of inflammation and autoimmune processes within the central nervous system (CNS) is whether resident microglia or only infiltrating macrophage can productively interact with T-cells that enter the CNS either actively through extravasation or passively through
Preventive therapy for tuberculosis in HIV infection.: JAMA. 1999 Mar 10;281(10):881-2. Unique Identifier : AIDSLINE MED/99176351; Brewer TF; Brigham & Women's Hospital, Boston, Mass, USA.; timothy.brewer@channing.harvard.edu
HIV researchers air new findings [news]: JAMA. 1999 Mar 10;281(10):883-5. Unique Identifier : AIDSLINE MED/99176352; Stephenson J
HIV vaccine trial in Africa [news]: JAMA. 1999 Mar 10;281(10):889. Unique Identifier : AIDSLINE MED/99181727; Voelker R
Influenza-associated morbidity and mortality in young and middle-aged women [see comments]: JAMA. 1999 Mar 10;281(10):901-7. Unique Identifier : AIDSLINE MED/99176372; Neuzil KM; Reed GW; Mitchel EF Jr; Griffin MR; Department of Medicine, University of Washington School of; Medicine, and the Veterans Affairs Medical Center, Seattle, USA.; CONTEXT: Data are limited on rates of influenza-associated hospitalizations and deaths among adults younger than 65 years. OBJECTIVE: To quantify serious morbidity and mortality from influenza for women younger than 65 years with and without certain chronic medical conditions, including human immunodeficiency virus in
Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus.: JAMA. 1999 Mar 10;281(10):931-6. Unique Identifier : AIDSLINE MED/99176377; Henderson DK; Office of the Deputy Director for Clinical Care, Warren G.; Magnuson Clinical Center, National Institutes of Health,; Bethesda, MD 20892-1504, USA. dkh@nih.gov
[Protease inhibitor-associated hypertriglyceridemia and diabetes mellitus in HIV-infected patients (letter)]: Med Clin (Barc). 1998 Nov 7;111(15):599. Unique Identifier : AIDSLINE MED/99076195; Knobel H; Goday A; Grau S
Using physical-chemistry-based substitution models in phylogenetic analyses of HIV-1 subtypes.: Mol Biol Evol. 1999 Feb;16(2):173-9. Unique Identifier : AIDSLINE MED/99152611; Koshi JM; Mindell DP; Goldstein RA; Biophysics Research Division, University of Michigan, Ann Arbor; 48109-1055, USA.; HIV-1 subtype phylogeny is investigated using a previously developed computational model of natural amino acid site substitutions. This model, based on Boltzmann statistics and Metropolis kinetics, involves an order of magnitude fewer adjustable parameters than traditional substitution matrices and deals more effectiv
Species and strain-specific typing of Cryptosporidium parasites in clinical and environmental samples.: Mem Inst Oswaldo Cruz. 1998 Sep-Oct;93(5):687-91. Unique Identifier : AIDSLINE MED/99048231; Xiao L; Sulaiman I; Fayer R; Lal AA; Division of Parasitic Diseases, Centers for Disease Control and; Prevention, US Department of Health and Human Services, Atlanta,; GA 30341, USA.; Cryptosporidiosis has recently attracted attention as an emerging waterborne and foodborne disease as well as an opportunistic infection in HIV infected individuals. The lack of genetic information, however, has resulted in confusion in the taxonomy of Cryptosporidium parasites and in the development of molecular tool
Use of planar lipid bilayer membranes for rapid screening of membrane active compounds.: Methods Enzymol. 1999;294:661-74. Unique Identifier : AIDSLINE MED/99114285; Mirzabekov TA; Silberstein AY; Kagan BL; Department of Pathology, Dana Farber Cancer Institute, Harvard; Medical School, Boston, Massachusetts 02115, USA.
Leishmania donovani infection of a susceptible host results in apoptosis of Th1-like cells: rescue of anti-leishmanial CMI by providing Th1-specific bystander costimulation.: Microbiol Immunol. 1998;42(11):795-801. Unique Identifier : AIDSLINE MED/99101244; Das G; Vohra H; Saha B; Agrewala JN; Mishra GC; National Center for Cell Sciences, Ganeshkhind, India.; A protective immune response against Leishmania donovani infection is mediated by T-helper type 1 (Th1) cells. Th1 induced cell-mediated immunity (CMI), as assessed by anti-leishmanial DTH response, is lost in a susceptible host such as BALB/c mice. Although the impaired Th1 function eventuates in unhindered parasite
Former Pasteur head defends politicians [news]: Nature. 1999 Feb 25;397(6721):635. Unique Identifier : AIDSLINE MED/99165203; Butler D
[Thalidomide once more in the spotlight]: Ned Tijdschr Geneeskd. 1998 Nov 14;142(46):2509-12. Unique Identifier : AIDSLINE MED/99152692; de Jong-van den Berg LT; Rutgers J; Cornel MC; Afd. Sociale Farmacie en Farmaco-epidemiologie, Groninger; Institute for Drug Studies, Rijksuniversiteit, Ant., Groningen.; Thalidomide was withdrawn from the market in the early sixties because of major teratogenic effects such as reduction defects of the limbs. Since, however, it has been found to be an effective drug in erythema nodosum leprosum. In the United States it was decided in September 1997 to a
[Infection with Mycobacterium genavense in 2 HIV-seropositive patients in Amsterdam (letter)]: Ned Tijdschr Geneeskd. 1998 Nov 14;142(46):2537-8. Unique Identifier : AIDSLINE MED/99152699; Van der Ven AJ; Jacobs JA; Schrey G
Erythropoietin treatment for non-uremic patients: a personal view.: Neth J Med. 1999 Jan;54(1):10-5. Unique Identifier : AIDSLINE MED/99157850; Biesma DH; Department of Internal Medicine, St. Antonius Ziekenhuis, CM; Nieuwegein, The Netherlands.; The correction of anemia in patients with chronic renal failure (CRF) has become the most important application of recombinant human erythropoietin (rHuEpo). The merits of rHuEpo therapy in patients with CRF are overt. Firstly, patients with CRF have an absolute deficiency in endogenous erythropoietin production and a
Fluorophotometry in patients with human immunodeficiency virus with and without cytomegalovirus retinitis.: Ophthalmology. 1999 Mar;106(3):590-3. Unique Identifier : AIDSLINE MED/99178304; Banker AS; Arevalo JF; Azen SP; Munguia D; Ishimoto B; Rahhal FM; Xiang M; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California San Diego, La Jolla 92093-0946, USA.; OBJECTIVE: To study the aqueous humor dynamics in subjects with human immunodeficiency virus (HIV) with and without cytomegalovirus ( CMV ) retinitis. DESIGN: Prospective cross-sectional study. PARTICIPANTS: Fourteen HIV-positi
Lack of acceptance of guidelines for prevention of disseminated Mycobacterium avium complex infection in infants and children infected with human immunodeficiency virus.: Pediatr Infect Dis J. 1998 Dec;17(12):1131-5. Unique Identifier : AIDSLINE MED/99093188; Chong CY; Husson RN; Children's Hospital, and Department of Pediatrics, Harvard; Medical School, Boston, MA 02115, USA.; BACKGROUND: Disseminated Mycobacterium avium complex (DMAC) infection occurs in HIV-infected children and adults with advanced immunosuppression. Prophylactic therapy has been shown to prevent this infection in adults with low CD4 cell counts. The United States Public Health Service an
Human herpesvirus 8 is not associated with Kawasaki disease [letter]: Pediatr Infect Dis J. 1998 Dec;17(12):1179. Unique Identifier : AIDSLINE MED/99093205; Yoshikawa T; Ihira M; Suzuki K; Suga S; Asano Y
Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database.: Nucleic Acids Res. 1999 Jan 1;27(1):348-52. Unique Identifier : AIDSLINE MED/99063736; Shafer RW; Stevenson D; Chan B; Division of Infectious Diseases, Stanford University Medical; Center, Stanford, CA 94305, USA. rshafer@cmgm.stanford.edu; The HIV RT and Protease Sequence Database is an on-line relational database that catalogues evolutionary and drug-related human immunodeficiency virus reverse transcriptase (RT) and protease sequence variation (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease
Identification of promoter elements in mycobacteria: mutational analysis of a highly symmetric dual promoter directing the expression of replication genes of the Mycobacterium plasmid pAL5000.: Nucleic Acids Res. 1999 Jan 15;27(2):396-402. Unique Identifier : AIDSLINE MED/99081833; Stolt P; Zhang Q; Ehlers S; Division of Molecular Infection Biology, Research Centre Borstel,; Parkallee 22, D-23845 Borstel, Germany. pstolt@altavista.net; The 120 bp origin of replication (ori) for the Mycobacterium plasmid pAL5000 has been shown to comprise the binding sites for the replication protein RepB as well as the start site of transcription for the repA and repB genes, encoding the replication proteins RepA and RepB. In this work it is demonstrated that a thir
The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure.: Nucleic Acids Res. 1999 Jan 15;27(2):446-54. Unique Identifier : AIDSLINE MED/99081840; Klasens BI; Thiesen M; Virtanen A; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, Meibergdreef 15,1105 AZ Amsterdam, The; Netherlands.; The 5 and 3 ends of HIV-1 transcripts are identical in sequence. This repeat region (R) folds a stem-loop structure that is termed the poly(A) hairpin because it contains polyadenylation or poly(A) signals: the AAUAAA hexamer motif, the cleavage site and part of the GU-rich downstream element. Obviously, HIV-1 gene
Specification of social support behaviours and network dimensions along the HIV continuum for gay men.: Patient Educ Couns. 1998 Jun;34(2):147-57. Unique Identifier : AIDSLINE MED/98401127; Pakenham KI; Department of Psychology, University of Queensland, Brisbane,; Australia.; This study aimed to investigate social supports that HIV-infected persons find helpful and unhelpful, and the size and composition of networks along the disease continuum. Ninety six HIV-infected and 33 seronegative gay men were interviewed. The HIV continuum was represented by seronegative, HIV asymptomatic and sympt
Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcription.: Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):459-64. Unique Identifier : AIDSLINE MED/99110912; Chan B; Weidemaier K; Yip WT; Barbara PF; Musier-Forsyth K; University of Minnesota, Department of Chemistry, 207 Pleasant; Street Southeast, Minneapolis, MN 55455, USA.; We report here the direct measurement of intra-tRNA distances during annealing of the tRNA primer to the HIV RNA genome. This key step in the initiation of retroviral reverse transcription involves hybridization of one strand of the acceptor arm of a specific lysine tRNA to the primer binding site on the RNA genome. A
Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes.: Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):622-7. Unique Identifier : AIDSLINE MED/99110940; Amsen D; Revilla Calvo C; Osborne BA; Kruisbeek AM; Division of Immunology, The Netherlands Cancer Institute,; Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.; A major question in end-stage T cell development is how T cell receptor(TCR) ligation on immature CD4(+)CD8(+) double positive thymocytes is translated into either survival (positive selection) or apoptotic (negative selection) signals. Because different types of antigen-presenting cells (APCs) induce positive or nega
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.: Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):651-6. Unique Identifier : AIDSLINE MED/99110945; Lillard JW Jr; Boyaka PN; Chertov O; Oppenheim JJ; McGhee JR; Department of Microbiology, University of Alabama, 273A BBRB, 845; 19th Street South, Birmingham, AL 35294-2170, USA.; Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus ovalbumin (OVA) enhanced OVA-specific serum IgG antibody (Ab) responses. However, OVA-specific IgA Abs were not induced in mucosal secretions or in serum. CD4(+) T c
CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue.: Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):663-8. Unique Identifier : AIDSLINE MED/99110947; Penn ML; Grivel JC; Schramm B; Goldsmith MA; Margolis L; Gladstone Institute of Virology and Immunology, Department of; Medicine, School of Medicine, University of California San; Francisco, San Francisco, CA 94141-9100, USA.; The human chemokine receptors CCR5 and CXCR4 have emerged as the predominant cofactors, along with CD4, for cellular entry of HIV-1 in vivo whereas the contribution of other chemokine receptors to HIV disease has not been yet determined. CCR5-specific (R5) viruses predominate during primary HIV-1 infection whereas vir
A role for RNA helicase A in post-transcriptional regulation of HIV type 1.: Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):709-14. Unique Identifier : AIDSLINE MED/99110955; Li J; Tang H; Mullen TM; Westberg C; Reddy TR; Rose DW; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla, CA 92093, USA.; Retroviruses must bypass the tight coupling of splicing and nuclear export of mRNA in their replication cycle because unspliced genomic RNA and incompletely spliced mRNA must be exported to the cytoplasm for packaging or translation. This process is mediated by a cis-acting constitutive transport element (CTE) for sim
HIV service provision and training needs in outpatient mental health settings.: Psychiatr Q. 1999 Spring;70(1):63-74. Unique Identifier : AIDSLINE MED/99123808; Satriano J; Rothschild RR; Steiner J; Oldham JM; HIV/AIDS Programs, New York State Office of Mental Health, USA.; Satrian@pioracle.cpmc.columbia.edu; OBJECTIVE: Despite high rates of HIV infection among people with serious mental illness little is known about the provision of HIV related services in outpatient mental health settings. This study examined HIV service provision and staff training needs among New York State outpatient providers. METHODS: An anonymous s
Psychosocial correlates of heterosexual condom use: a meta-analysis.: Psychol Bull. 1999 Jan;125(1):90-132. Unique Identifier : AIDSLINE MED/99144657; Sheeran P; Abraham C; Orbell S; Department of Psychology, University of Sheffield, United; Kingdom. p.sheeran@sheffield.ac.uk; Despite increasing incidence of HIV/AIDS, there has been no systematic review of correlates of condom use among heterosexual samples. To rectify this, the present study used meta-analysis to quantify the relationship between psychosocial variables and self-reported condom use. Six hundred sixty correlations distribute
Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1.: Res Immunol. 1998 Sep-Oct;149(7-8):633-7. Unique Identifier : AIDSLINE MED/99066839; Kodelja V; Kraft S; Politz O; Hakij N; Treudler R; Orfanos CE; Bieber T; Goerdt S; Klinik und Poliklinik fur Dermatologie, Universitatsklinikum; Benjamin Franklin, Freie Universitat Berlin, Germany.; We have cloned a novel human CC chemokine, alternative macrophage activation-associated CC chemokine (AMAC)-1 that is highly homologous to macrophage inflammatory protein (MIP)-1alpha. In contrast to MIP-1alpha, AMAC-1 is induced in macrophages by Th2-associated cytokines IL4, IL13, and IL10 in vitro; in addition, AMA
Macrophage- and lymphocyte-produced Th1 and Th2 cytokines in the tumour microenvironment.: Res Immunol. 1998 Sep-Oct;149(7-8):651-3. Unique Identifier : AIDSLINE MED/99066843; Fridman WH; Tartour E; Laboratoire d'Immunologie Clinique, INSERM U255, Institut Curie,; Paris.
A gender gap in autoimmunity.: Science. 1999 Feb 26;283(5406):1277-8. Unique Identifier : AIDSLINE MED/99174475; Whitacre CC; Reingold SC; O'Looney PA; Department of Medical Microbiology and Immunology, Ohio State; University, Columbus, OH 43210, USA. whitacre.3@osu.edu
Cobalamin deficiency in patients infected with the human immunodeficiency virus.: Semin Hematol. 1999 Jan;36(1):75-87. Unique Identifier : AIDSLINE MED/99127760; Remacha AF; Cadafalch J; Department of Hematology, Hospital de la Santa Creu i Sant Pau,; Barcelona, Spain.; Serum vitamin B12 levels are often low in human immunodeficiency virus (HIV)-infected patients. However, only a few patients appear to have actual vitamin B12 deficiency. A low red cell folate level accompanying the low vitamin B12 level makes the presence of vitamin B12 deficiency more likely. Our experience suggests
[Listeria monocytogenes--an opportunist with serious intentions]: Tidsskr Nor Laegeforen. 1999 Jan 30;119(3):354. Unique Identifier : AIDSLINE MED/99174397; Lassen J; Avdeling for bakteriologi Statens institutt for folkehelse, Oslo.
HLA class I and class II of the Nivkhi, an indigenous population carrying HTLV-I in Sakhalin, Far Eastern Russia.: Tissue Antigens. 1998 Nov;52(5):444-51. Unique Identifier : AIDSLINE GENBANK/AB010270; Lou H; Li HC; Kuwayama M; Yashiki S; Fujiyoshi T; Suehara M; Osame M; Yamashita M; Hayami M; Gurtsevich V; Ballas M; Imanishi T; Sonoda S; Department of Virology, Faculty of Medicine, Kagoshima; University, Sakuragaoka, Japan.; The Nivkhi are a native people isolated in the Nogliki region of Sakhalin, Far East Russia , where our group recently recognized human T-cell lymphoma virus type I (HTLV-I) infection. In order to trace the Nivkhi s ethnic background and the HTLV-I carriers, we investigated HLA class
Concanavalin A-stimulated proliferation of T cell subset-depleted lymphocyte populations isolated from Fasciola hepatica-infected cattle.: Vet Immunol Immunopathol. 1998 Dec 11;66(3-4):289-300. Unique Identifier : AIDSLINE MED/99094714; McCole DF; Doherty ML; Baird AW; Davis WC; McGill K; Torgerson PR; Department of Pharmacology, University College Dublin, Ireland.; Over 14 weeks, peripheral blood lymphocytes (PBL) were isolated from eight adult cattle which had been orally infected with Fasciola hepatica via trickle infection over a 10-day period. Two age, breed and sex-matched cattle served as controls. CD4+, CD8+ and gammadelta+ T cells were depleted from whole PBL populations
Complementarity between 3' terminal nucleotides of tRNA and primer binding site is a major determinant for selection of the tRNA primer used for initiation of HIV-1 reverse transcription.: Virology. 1999 Feb 1;254(1):160-8. Unique Identifier : AIDSLINE MED/99128408; Yu Q; Morrow CD; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama, 35294, USA.; The initiation of reverse transcription of human immunodeficiency virus type 1 (HIV-1) exclusively utilizes tRNALys,3 as a primer. Previous studies have shown that HIV-1 could use alternative tRNAs, such as tRNAIle or tRNAHis, to initiate reverse transcription only if the primer binding site (PBS) was made complementa
A particulate viral protein vaccine reduces viral load and delays progression to disease in immunized ponies challenged with equine infectious anemia virus.: Virology. 1999 Feb 1;254(1):37-49. Unique Identifier : AIDSLINE MED/99128397; Hammond SA; Cook SJ; Falo LD Jr; Issel CJ; Montelaro RC; Departments of Molecular Genetics and Biochemistry, University of; Pittsburgh, Pittsburgh, Pennsylvania, 15261, USA.; Immunization regimens that induce a broadly reactive cytolytic T lymphocyte (CTL) response specific for lentiviral antigens have emerged as the leading candidates in efficacy trials conducted in both animal modelshumans. To date, lentivirus vaccination strategies have overlooked one such immunization strategy, namely
Interaction of the capsid protein p24 (HIV-1) with sequence-derived peptides: influence on p24 dimerization.: Virology. 1999 Feb 1;254(1):6-10. Unique Identifier : AIDSLINE MED/99128394; Hilpert K; Behlke J; Scholz C; Misselwitz R; Schneider-Mergener J; Hohne W; Institut fur Biochemie, Universitatsklinikum Charite, Berlin,; D-10098, Germany.; Protein-protein interactions of the p24 (HIV-1) capsid protein play an essential role in the production of infectious virus particles. To map the putative p24 dimerization site, a set of overlapping peptides spanning the p24 sequence was prepared using spot synthesis on a cellulose membrane and probed with recombinant
Selection of the R17Y substitution in SIVmac239 nef coincided with a dramatic increase in plasma viremia and rapid progression to death.: Virology. 1999 Feb 1;254(1):61-70. Unique Identifier : AIDSLINE MED/99128399; Kirchhoff F; Carl S; Sopper S; Sauermann U; Matz-Rensing K; Stahl-Hennig C; Institute for Clinical and Molecular Virology, University of; Erlangen-Nurnberg, Schlossgarten 4, Erlangen, 91054, Germany.; fkkirchh@viro.med.uni-erlangen.de; Three rhesus macaques were infected with an SIVmac239 variant containing substitutions of 73/74PA-->ED and 204D-->R in Nef that disrupted the ability of Nef to downregulate CD4 surface expression. One of these animals, Mm8155, rapidly progressed to AIDS and died 21 weeks postinfection. During the final 5 weeks of infe
Report of the Second Workshop on Age Adjustment.: Vital Health Stat 4. 1998 Dec;(30):I-VI, 1-37. Unique Identifier : AIDSLINE MED/99169401; Anderson RN; Rosenberg HM; U.S. Department of Health and Human Services, Centers for Disease; Control and Prevention, National Center for Health Statistics,; Hyattsville, Maryland, USA.; This report contains a summary of the Second Workshop on Age Adjustment held at the National Center for Health Statistics on June 5-6, 1997. The workshop, which was a follow up to the First Workshop on Age Adjustment (1991), was held to consider changing the standard used for age-adjusting death rates and to develop a
Evidence against KSHV infection in the pathogenesis of multiple myeloma.: Virus Res. 1998 Oct;57(2):197-202. Unique Identifier : AIDSLINE MED/99086134; Olsen SJ; Tarte K; Sherman W; Hale EE; Weisse MT; Orazi A; Klein B; Chang Y; Division of Epidemiology, School of Public Health, Columbia; University, New York, NY 10032, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is likely to play a pathogenic role in Kaposi s sarcoma, body cavity-based primary effusion lymphoma and a subset of Castleman s disease. A recent polymerase chain reaction (PCR)-based study reported an association between KSHV and multiple myeloma (MM). We searched for K
Cancer gene therapy with a heat shock protein gene.: Adv Exp Med Biol. 1998;451:217-23. Unique Identifier : AIDSLINE MED/99150937; Pardo OE; Colston JM; Lukacs KV; National Heart and Lung Institute, Imperial College, London,; United Kingdom.
DNA immunization in mice against virus-induced tumor antigens.: Adv Exp Med Biol. 1998;451:311-4. Unique Identifier : AIDSLINE MED/99150951; Milan G; Rosato A; Zambon A; Zanovello P; Collavo D; Department of Oncology and Surgical Sciences, University of; Padova, Italy.
Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.: Adv Exp Med Biol. 1998;451:43-9. Unique Identifier : AIDSLINE MED/99150910; Gunthert U; Schwarzler C; Wittig B; Laman J; Ruiz P; Stauder R; Bloem A; Smadja-Joffe F; Zoller M; Rolink A; Basel Institute for Immunology, Switzerland.; ursula.guenthert@bii.ch
Autoerotic asphyxial death--accident or suicide?: Am J Forensic Med Pathol. 1998 Dec;19(4):377-80. Unique Identifier : AIDSLINE MED/99101026; Byard RW; Botterill P; State Forensic Science, Adelaide, Australia.; rbyard@mad.adelaide.edu.au; Death during autoerotic asphyxial activity is usually considered accidental due to unanticipated failure of the device that was used to induce hypoxia during sexual arousal. Two cases of hanging are reported in which apparently typical features of autoerotic asphyxial activity were present. As a result of the discover
AIDS & HIV: evidence of actual exposure--Majca v. Beekil.: Am J Law Med. 1998;24(4):513-4. Unique Identifier : AIDSLINE MED/99094067; Sinclair PS
[Human herpesvirus 8 (HHV8). II. Pathogenic role and sensitivity to antiviral drugs]: Ann Biol Clin (Paris). 1999 Jan-Feb;57(1):19-28. Unique Identifier : AIDSLINE MED/99120878; Boulanger E; Service d'hematologie clinique, hopital Saint-Louis, Paris.; Human herpesvirus 8 (HHV8) has been found to be associated with three different diseases observed in Aids patients: Kaposi s sarcoma, primary effusion lymphoma, which is a rare type of non-Hodgkin lymphomas affecting the body cavities, and multicentric Castleman s disease. The role of this new herpesvirus and other ly
Novel protein toxin-based strategy for development of cytotoxic T lymphocyte vaccines.: Arch Immunol Ther Exp (Warsz). 1998;46(6):341-6. Unique Identifier : AIDSLINE MED/99099765; Wiedlocha A; Department of Biochemistry, Norwegian Radium Hospital,; Montebello, Oslo, Norway.; Specific activation of CD8+ cytotoxic T lymphocytes (CTL) is crucial to elicit immunity against intracellular pathogens including viruses, bacteria and protozoa. CTLs recognize mainly intracellularly processed peptides of pathogen origin associated with major histocompatibility complex class I molecules (MHC class I)
[Serologic and virologic investigations on the presence of BLV infection in a dairy herd in Syria]: Berl Munch Tierarztl Wochenschr. 1999 Jan;112(1):18-23. Unique Identifier : AIDSLINE MED/99153103; Kurdi A; Blankenstein P; Marquardt O; Ebner D; Department of Microbiology, Faculty of Veterinary Medicine,; Al-Baath-University Homs, Syria.; 237 cattle of a dairy herd in Syria were tested for anti-BLV antibody by the ELISA. 194 animals were additionally examined by the agar gel immunodiffusions test (AGID) on BLV antibodies and 100 by polymerase chain reaction (PCR) for
Viral ion channels: molecular modeling and simulation.: Bioessays. 1998 Dec;20(12):992-1000. Unique Identifier : AIDSLINE MED/99157859; Sansom MS; Forrest LR; Bull R; Department of Biochemistry, University of Oxford, UK.; mark@biop.ox.ac.uk; In a number of membrane-bound viruses, ion channels are formed by integral membrane proteins. These channel proteins include M2 from influenza A, NB from influenza B, and, possibly, Vpu from HIV-1. M2 is important in facilitating uncoating of the influenza A viral genome and is the target of amantadine, an anti-influe
T cell immunity to oral allergens.: Curr Opin Immunol. 1998 Dec;10(6):620-7. Unique Identifier : AIDSLINE MED/99116007; MacDonald TT; Department of Paediatric Gastroenterology St Bartholomews and the; Royal London School of Medicine and Dentistry St Bartholomews; Hospital London EC1A 7BE UK. t.t.macdonald@mds.qmw.ac.uk; Considerable light has been thrown on the mechanisms of oral tolerance (or, more correctly, orally-induced systemic tolerance) in the past 12-18 months. While it is very clear that T cell anergy and apoptosis can occur after being fed antigen, a major pathway that has been described in different models is the inductio
CD8+ T cells in atopic disease.: Curr Opin Immunol. 1998 Dec;10(6):628-33. Unique Identifier : AIDSLINE MED/99116008; Kemeny DM; Department of Immunology Guy's King's and St Thomas's School of; Medicine King's College London SE5 9NU UK. david.kemeny@kcl.ac.uk; In recent years there has been a tremendous expansion in our understanding about CD8(+) T cells. We now know that, as for CD4(+) T cells, they can be divided into subsets (Tc1 and Tc2) according to the cytokines they secrete. These subsets may differ in their capacity to kill and may even, in some cases, provide help
Comparison of the plasma pharmacokinetics and renal clearance of didanosine during once and twice daily dosing in HIV-1 infected individuals.: AIDS. 1998 Dec 3;12(17):F211-6. Unique Identifier : AIDSLINE MED/99079566; Hoetelmans RM; van Heeswijk RP; Profijt M; Mulder JW; Meenhorst PL; Lange JM; Reiss P; Beijnen JH; Department of Pharmacy & Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; OBJECTIVE: To compare the plasma pharmacokinetics of didanosine during once daily (qd) and twice daily (bid) dosing. DESIGN: Open-label, randomized, cross-over study. METHODS: HIV-1 infected patients who used didanosine were randomized to either a qd or a bid dosing regimen of didanosine. The total daily dose of didan
Restored humoral immune response to influenza vaccination in HIV-infected adults treated with highly active antiretroviral therapy.: AIDS. 1998 Dec 3;12(17):F217-23. Unique Identifier : AIDSLINE MED/99079567; Kroon FP; Rimmelzwaan GF; Roos MT; Osterhaus AD; Hamann D; Miedema F; van Dissel JT; Department of Infectious Diseases, Leiden University Medical; Center, The Netherlands.; BACKGROUND: Highly active antiretroviral therapy (HAART) effectively suppresses replication of HIV and is accompanied by an increase in CD4+ T lymphocytes. Whether the increase in CD4+ T lymphocytes in the blood is a reflection of a reconstitution of the immune functions is unknown. We investigated the recovery of the
Randomized, controlled phase II trial of subcutaneous interleukin-2 in combination with highly active antiretroviral therapy (HAART) in HIV patients.: AIDS. 1998 Dec 3;12(17):F225-34. Unique Identifier : AIDSLINE MED/99079568; Hengge UR; Goos M; Esser S; Exner V; Dotterer H; Wiehler H; Borchard C; Muller K; Beckmann A; Eppner MT; Berger A; Fiedler M; Department of Dermatology and Venerology, University of Essen,; Germany.; OBJECTIVE: To determine the immunological, virological and clinical effects of subcutaneous IL-2 in 44 HIV-patients in conjunction with pre-existing tri-therapy (zidovudine, 3TC , saquinavir). DESIGN: P
Complications of surgery in HIV-infected patients [editorial]: AIDS. 1998 Dec 3;12(17):2243-51. Unique Identifier : AIDSLINE MED/99079569; Rose DN; Collins M; Kleban R
Levels of HIV-infected peripheral blood cells remain stable throughout the natural history of HIV-1 infection. Swiss HIV Cohort Study.: AIDS. 1998 Dec 3;12(17):2253-60. Unique Identifier : AIDSLINE MED/99079570; Cone RW; Gowland P; Opravil M; Grob P; Ledergerber B; Department of Internal Medicine, University Hospital, Zurich,; Switzerland.; OBJECTIVE: To clarify the relationship between the number of provirus-bearing peripheral blood mononuclear cells (PBMC) and HIV-1 disease progression during the natural history of infection. DESIGN: Twenty-four HIV-1-infected subjects with known seroconversion dates and long-term follow-up were retrospectively identif
Live attenuated simian immunodeficiency virus (SIV)mac in macaques can induce protection against mucosal infection with SIVsm.: AIDS. 1998 Dec 3;12(17):2261-70. Unique Identifier : AIDSLINE MED/99079571; Nilsson C; Makitalo B; Thorstensson R; Norley S; Binninger-Schinzel D; Cranage M; Rud E; Biberfeld G; Putkonen P; Swedish Institute for Infectious Disease Control and Microbiology; and Tumourbiology Centre, Karolinska Institute, Stockholm.; OBJECTIVE: To investigate whether vaccination of macaques with attenuated simian immunodeficiency virus (SIV)macC8 could induce long-term protective immunity against rectal exposure to SIVsm and intravenous exposure to the more divergent HIV-2. DESIGN AND METHODS: Eight months after vaccination with live attenuated SI
The estimated impact of the CCR-5 delta32 gene deletion on HIV disease progression varies with study design. Oslo HIV Cohort Study Group.: AIDS. 1998 Dec 3;12(17):2271-4. Unique Identifier : AIDSLINE MED/99079572; Eskild A; Jonassen TO; Heger B; Samuelsen SO; Grinde B; Section of Epidemiology, National Institute of Public Health,; Oslo, Norway.; OBJECTIVES: To study the impact of the genotype CCR-5 wild-type +/A32 on the progression rate to AIDS and death, and to discuss sources of bias according to study design. METHODS: A prospective study of 310 HIV-positive subjects with follow-up time from study entry (prevalent cohort), and a prospective study of 105 HI
Presence of the variant mannose-binding lectin alleles associated with slower progression to AIDS. Amsterdam Cohort Study.: AIDS. 1998 Dec 3;12(17):2275-80. Unique Identifier : AIDSLINE MED/99079573; Maas J; de Roda Husman AM; Brouwer M; Krol A; Coutinho R; Keet I; van Leeuwen R; Schuitemaker H; Department of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands.; OBJECTIVE: To examine the association between mannose-binding lectin (MBL) polymorphism and progression to AIDS and death in HIV-1 infection. DESIGN AND METHODS: In 131 HIV-1-infected homosexual seroconverters, survival analyses were performed to determine both the association between MBL genotype and time from HIV-1
Selective vertical transmission of HIV-1 antiretroviral resistance mutations.: AIDS. 1998 Dec 3;12(17):2281-8. Unique Identifier : AIDSLINE MED/99079574; Colgrove RC; Pitt J; Chung PH; Welles SL; Japour AJ; Division of Infectious Diseases, Beth Israel Deaconess Medical; Center, Harvard School of Medicine, Boston, Massachusetts 02215,; USA.; OBJECTIVE: To examine the patterns of vertical transmission of zidovudine (ZDV) resistance mutations. DESIGN: HIV-1 reverse transcriptase codons 10-250 were sequenced from 24 pairs of ZDV-exposed women and their HIV-infected infants as part of the Women and Infants Transmission Study. METHODS: Viral RNA was extracted
Hepatitis C virus-associated hepatitis following treatment of HIV-infected patients with HIV protease inhibitors: an immune restoration disease?: AIDS. 1998 Dec 3;12(17):2289-93. Unique Identifier : AIDSLINE MED/99079575; John M; Flexman J; French MA; Department of Clinical Immunology, Royal Perth Hospital, Western; Australia, Australia.; OBJECTIVE: To report observations from case studies on the pathogenic mechanisms underlying the acute hepatitis that sometimes occurs in hepatitis C virus (HCV) and HIV coinfected patients following treatment with potent antiretroviral therapy that includes a HIV protease inhibitor. METHODS: Cases of acute hepatitis w
Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial.: Unique Identifier : AIDSLINE MED/99079576; Kastrissios H; Suarez JR; Katzenstein D; Girard P; Sheiner LB; Blaschke TF; OBJECTIVE: To characterize drug-taking behavior using continuous electronic monitoring in an AIDS clinical trial. SETTING: This was a substudy of AIDS Clinical Trials Group (ACTG) protocol 175, a phase II/III study of dideoxynucleoside monotherapy versus combination therap
The extent of non-adherence in a large AIDS clinical trial using plasma dideoxynucleoside concentrations as a marker.: AIDS. 1998 Dec 3;12(17):2305-11. Unique Identifier : AIDSLINE MED/99079577; Kastrissios H; Suarez JR; Hammer S; Katzenstein D; Blaschke TF; Division of Clinical Pharmacology, Stanford University School of; Medicine, California 94305-5130, USA.; OBJECTIVES: To assess adherence to study medications in an AIDS clinical trial, to evaluate whether study participants adhered to only one component of a multidrug regimen ( differential adherence ), and to determine whether there was evidence of non-uniform adherence to study medications among treatment groups. SETTI
Changes in CD4+ cell count and the risk of opportunistic infection or death after highly active antiretroviral treatment. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine.: AIDS. 1998 Dec 3;12(17):2313-20. Unique Identifier : AIDSLINE MED/99079578; Chene G; Binquet C; Moreau JF; Neau D; Pellegrin I; Malvy D; Ceccaldi J; Lacoste D; Dabis F; Unite INSERM 330, Universite Victor Segalen Bordeaux 2, France.; OBJECTIVE: To study the relationship between the CD4+ cell response after initiation of protease inhibitors and the occurrence of opportunistic infections and survival. DESIGN: Prospective observational cohort study. METHODS: HIV-1-seropositive subjects followed-up
Catheter complications in AIDS patients treated for cytomegalovirus retinitis.: AIDS. 1998 Dec 3;12(17):2321-7. Unique Identifier : AIDSLINE MED/99079579; Thorne JE; Jabs DA; Vitale S; Miller T; Dunn JP; Semba RD; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; PURPOSE: To describe the complications of central venous catheter use for intravenous therapy of cytomegalovirus ( CMV ) retinitis in patients with AIDS. METHODS: Retrospective review of 388 patients with AIDS and CMV retinitis
Improving quality of sexually transmitted disease case management in rural South Africa.: AIDS. 1998 Dec 3;12(17):2329-35. Unique Identifier : AIDSLINE MED/99079580; Harrison A; Wilkinson D; Lurie M; Connolly AM; Karim SA; Centre for Epidemiological Research in South Africa, Medical; Research Council, Mtubatuba.; OBJECTIVE: To measure quality of sexually transmitted disease (STD) syndromic case management and aspects of health-seeking behaviour at baseline in an intervention trial. SETTING: Ten rural primary care clinics, Hlabisa district, South Africa . DESIGN: Simulated patients (fieldwor
Attitude of pregnant women towards HIV testing in Abidjan, Cote d'Ivoire and Bobo-Dioulasso, Burkina Faso. DITRAME Study Group (ANRS 049 Clinical Trial). Diminution de la Transmission Mere Enfant du VIH. Agence Nationale de Recherches sur le SIDA.: AIDS. 1998 Dec 3;12(17):2337-44. Unique Identifier : AIDSLINE MED/99079581; Cartoux M; Msellati P; Meda N; Welffens-Ekra C; Mandelbrot L; Leroy V; Van de Perre P; Dabis F; Centre Muraz, Bobo-Dioulasso, Burkina Faso.; OBJECTIVE: To evaluate the attitude of pregnant women towards HIV testing in two cities of West Africa: Abidjan, Cote d Ivoire and Bobo-Dioulasso, Burkina Faso . METHODS: In the context of a clinical trial to prevent HIV vertical transmissi
Detection of HIV-1 nucleic acid and HIV-1 antibodies in needles and syringes used for non-intravenous injection.: AIDS. 1998 Dec 3;12(17):2345-50. Unique Identifier : AIDSLINE MED/99079582; Rich JD; Dickinson BP; Carney JM; Fisher A; Heimer R; The Miriam Hospital and Brown University, Providence, Rhode; Island 02906, USA.; BACKGROUND: HIV antibodies and HIV DNA have been detected in needles and syringes that have been used for intravenous injections in HIV-infected persons. During intravenous injection, blood is typically aspirated into the lumen of the syringe. During intramuscular or subcutaneous injection, however, blood is not usual
Parenteral transmission of Kaposi's sarcoma-associated herpesvirus [letter]: Unique Identifier : AIDSLINE MED/99079583; Marcelin AG; Apetrei C; Dupin N; Bossi P; Descamps D; Simon F
Clinical utility of PCR on cerebrospinal fluid for the diagnosis and management of HIV neurological complications [letter]: AIDS. 1998 Dec 3;12(17):2352-3. Unique Identifier : AIDSLINE MED/99079584; Sadler M; Al-Shahi R; Weeks P; Nelson MR; Gazzard BG
Monitoring of pp65 antigenaemia test for cytomegalovirus after initiation of highly active antiretroviral therapy [letter]: AIDS. 1998 Dec 3;12(17):2353-4. Unique Identifier : AIDSLINE MED/99079585; Miguelez M; Diez O
Kaposi's sarcoma and protection from AIDS dementia complex [letter]: Unique Identifier : AIDSLINE MED/99079586; Dore GJ; Grulich A; Law MG; Brew BJ; Kaldor JM
Pneumocystis carinii prophylaxis can be discontinued after CD4+ cell recovery over 200 x 10(6)/l [letter]: AIDS. 1998 Dec 3;12(17):2355-6. Unique Identifier : AIDSLINE MED/99079587; Rodriguez-Guardado A; Maradona JA; Carton JA; Casado L; Asensi V
Ritonavir promotes increased growth in HIV-infected children. Paediatric AIDS Group of Switzerland [letter]: AIDS. 1998 Dec 3;12(17):2356-7. Unique Identifier : AIDSLINE MED/99079588; Nadal D; Steiner F; Cheseaux JJ; Rudin C
High rebound of plasma and cellular HIV load after discontinuation of triple combination therapy [letter]: AIDS. 1998 Dec 3;12(17):2358-9. Unique Identifier : AIDSLINE MED/99079589; Jubault V; Burgard M; Le Corfec E; Costagliola D; Rouzioux C; Viard JP
Rebound of HIV-1 viral load after suppression to very low levels [letter]: AIDS. 1998 Dec 3;12(17):2360. Unique Identifier : AIDSLINE MED/99079590; Staszewski S; Miller V; Sabin C; Berger A; Hill AM; Phillips AN
Nelfinavir and nevirapine interaction? [letter]: AIDS. 1998 Dec 3;12(17):2361. Unique Identifier : AIDSLINE MED/99079591; Mulcahy F; Barry M; Merry C; Back D
Adherence to combination antiretroviral therapy assessed by anonymous patient self-report [letter]: AIDS. 1998 Dec 3;12(17):2361-3. Unique Identifier : AIDSLINE MED/99079592; Walsh JC; Dalton M; Gazzard BG
AIDS-related information, opinions and attitudes among high school pupils in the Reggio Emilia area (Italy).: Ann Ig. 1998 Sep-Dec;10(5-6):315-23. Unique Identifier : AIDSLINE MED/99161348; Stampi S; Bergamaschi A; De Luca G; Zanetti F; Dip. di Medicina e Sanita Pubblica, Universita di Bologna.
HIV-1 gp120 induces the activation of both c-fos and c-jun immediate-early genes in HEL megakaryocytic cells.: Br J Haematol. 1999 Jan;104(1):81-6. Unique Identifier : AIDSLINE MED/99150042; Gibellini D; Re MC; Bassini A; Guidotti L; Catani L; La Placa M; Zauli G; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; We have previously demonstrated that the addition in culture of recombinant HIV-1 IIIB envelope gp120 affects the survival/growth of pluripotent haemopoietic progenitors, and, in particular, of those committed towards the megakaryocytic lineage. To characterize some of the molecular mechanisms involved in this phenome
The effect of epitope variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein.: Int Immunol. 1998 Dec;10(12):1789-99. Unique Identifier : AIDSLINE MED/99100990; Kmieciak D; Bednarek I; Takiguchi M; Wasik TJ; Bratosiewicz J; Wierzbicki A; Teppler H; Pientka J; Hsu SH; Kaneko Y; Kozbor D; Center for Neurovirology, Department of Neurology, Allegheny; University of the Health Sciences, Philadelphia, PA 19102, USA.; To address the relationship between viral and host factors during HIV infection, we analyzed the effect of viral mutations on T cell responses in seropositive, asymptomatic HLA-A2+ individuals using four envelope (env)-specific peptides with the HLA-A*0201 binding motif. We showed that the natural sequence variation w
Preferred CDRH3 lengths for antibodies with defined specificities.: Int Immunol. 1998 Dec;10(12):1801-5. Unique Identifier : AIDSLINE MED/99100991; Johnson G; Wu TT; Department of Biochemistry, Northwestern University, Evanston, IL; 60208, USA.; The third complementarity determining regions of heavy chain variable regions (CDRH3) confer the fine specificities of antibodies. The CDRH3 length distribution of all human or all mouse antibodies appears to be more or less random, with the human distribution having a wider spread. Since the Kabat database of aligned
Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes.: Int Immunol. 1998 Dec;10(12):1807-17. Unique Identifier : AIDSLINE MED/99100992; Ivanov VN; Nikolic-Zugic J; Laboratory of T Cell Development, Memorial Sloan-Kettering Cancer; Center, New York, NY 10021, USA.; We characterized kinetic and biochemical changes during glucocorticoid (GC)-induced apoptosis of immature CD8+CD4+ double-positive (DP) thymocytes. A GC analog dexamethasone (Dex) induced rapid apoptotic commitment and a transient up-regulation of the NF-kappaB/RelA-p50-binding activity in DP cells. This required an e
CD45RA(bright)/CD11a(bright) CD8+ T cells: effector T cells.: Int Immunol. 1998 Dec;10(12):1837-45. Unique Identifier : AIDSLINE MED/99100995; Hoflich C; Docke WD; Busch A; Kern F; Volk HD; Institute of Medical Immunology, University Hospital Charite,; Campus Mitte, Berlin, Germany.; An important aspect of peripheral T cell development is the differentiation from naive into memory cells. To distinguish naive from memory cells, CD45RA and CD11a are commonly used: CD45RA+ or CD11a(dim) T cells are regarded as naive, while CD45RA- or CD11a(bright) T cells are thought to be of memory type. There is, h
CD80 expression is decreased in hyperplastic lymph nodes of HIV+ patients.: Int Immunol. 1998 Dec;10(12):1847-51. Unique Identifier : AIDSLINE MED/99100996; Legendre C; Raphael M; Gras G; Lefevre EA; Feuillard J; Dormont D; Richard Y; CEA, Service de Neurovirologie, DSV/DRM, CRSSA, IPSC, Fontenay; aux Roses, France.; A centrofollicular hyperplasia is present within secondary lymphoid organs during all the asymptomatic phase of the HIV disease. Although this hyperplasia has been well characterized by histological studies, the nature of the phenotypic alterations in B cell populations occurring within HIV+ lymphoid organs remains to
Binding of CD4 ligands induces tyrosine phosphorylation of phosphatidylinositol-3 kinase p110 subunit.: Int Immunol. 1998 Dec;10(12):1897-905. Unique Identifier : AIDSLINE MED/99101002; Mazerolles F; Fischer A; INSERM U429, Hopital Necker-Enfants Malades, Paris, France.; We have previously reported that different putative CD4 ligands (anti-CD4 antibody, gp160 from HIV, synthetic peptides analogous to the residues 35-46 of HLA class II beta1 chain and residues 134-148 of HLA class II beta2 chain) down-regulate LFA-1-dependent adhesion between CD4+ T cells and HLA class II+ B cells, and
Rapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes.: Int Immunol. 1998 Dec;10(12):1907-16. Unique Identifier : AIDSLINE MED/99101003; Agrawal B; Krantz MJ; Reddish MA; Longenecker BM; Biomira Inc., Edmonton, Alberta, Canada.; Antigen-specific MHC class II- and class I-restricted helper and cytotoxic T cell responses are important anti-cancer immune responses. MUC1 mucin is a potentially important target for immunotherapy because of its high expression on most human adenocarcinomas. MUC1 peptide-specific type 1 T cell responses were generat
Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.: Int Immunol. 1998 Dec;10(12):1981-5. Unique Identifier : AIDSLINE MED/99101010; Takemoto N; Koyano-Nakagawa N; Yokota T; Arai N; Miyatake S; Arai K; Department of Molecular and Developmental Biology, The Institute; of Medical Science, The University of Tokyo, Japan.; IL-4 and IL-13 are cytokines preferentially produced by Th2 cells, and their genes are located in close proximity on human chromosome 5 and mouse chromosome 11. To identify potential regulatory elements that confer Th2-specific expression of IL-4 and IL-13 genes, we constructed a physical map of the IL-13/IL-4 locus a
Selection and characterization of an RNA decoy for transcription factor NF-kappa B.: Biochemistry. 1999 Mar 9;38(10):3168-74. Unique Identifier : AIDSLINE MED/99175115; Lebruska LL; Maher LJ 3rd; Department of Biochemistry and Molecular Biology, Mayo; Foundation, Rochester, Minnesota 55905, USA.; Despite their chemical similarity, DNA and RNA sequences typically adopt very different structures within cells and are recognized by different proteins. However, a few interesting examples of proteins with dual specificity for DNA and RNA have previously been noted. These observations raise the possibility that RNA s
Tyrosine 222, a member of the YXDD motif of MuLV RT, is catalytically essential and is a major component of the fidelity center.: Biochemistry. 1999 Mar 2;38(9):2617-27. Unique Identifier : AIDSLINE MED/99162251; Kaushik N; Singh K; Alluru I; Modak MJ; Department of Biochemistry and Molecular Biology, UMD-New Jersey; Medical School, Newark 07103, USA. modak@umdnj.edu; Tyrosine 222 of MuLV RT is an invariant residue of the highly conserved YXDD motif in the reverse transcriptase class of enzymes. The residue X is Met 184 in HIV-1 RT and Val 223 in MuLV RT. This residue has been implicated in the fidelity of DNA synthesis, whereas the role of the preceding tyrosine in this aspect, as
Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions.: Biochimie. 1998 Nov;80(11):899-904. Unique Identifier : AIDSLINE MED/99109947; Levi G; Minghetti L; Aloisi F; Laboratory of Pathophysiology, Istituto Superiore di Sanita,; Rome, Italy.; Brain prostanoid levels are normally low but can increase after ischemia and during inflammatory and infectious diseases. High prostanoid levels can affect brain function in several ways. In particular, prostaglandin E2 (PGE2) might exert both immunodepressive and proinflammatory actions. The present short review focu
Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth.: Biochimie. 1998 Aug-Sep;80(8-9):651-8. Unique Identifier : AIDSLINE MED/99081085; Pitha PM; Au WC; Lowther W; Juang YT; Schafer SL; Burysek L; Hiscott J; Moore PA; Oncology Center and Department of Molecular Biology & Genetics,; The Johns Hopkins University School of Medicine, Baltimore, MD; 21231, USA.; As a response to viral infection, cells express the early inflammatory genes that encode small proteins generally called cytokines or chemokines. These protein can activate immune responses to viral infection as well as to modulate directly the outcome of viral infection. The group of proteins with the direct antivira
Effects of IFN alpha on late stages of HIV-1 replication cycle.: Biochimie. 1998 Aug-Sep;80(8-9):745-54. Unique Identifier : AIDSLINE MED/99081095; Dianzani F; Castilletti C; Gentile M; Gelderblom HR; Frezza F; Capobianchi MR; Institute of Virology, University La Sapienza, Rome, Italy.; IFN alpha causes a modest reduction of HIV-1 expression in chronically infected monocytoid U937 cells. However, the ratio between cell-associated and shed viral p24 antigen is altered, being the cell-associated fraction dose-dependently enhanced by IFN. Furthermore, a significant decrease of infectivity of both cell-a
IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities.: Biochimie. 1998 Aug-Sep;80(8-9):755-77. Unique Identifier : AIDSLINE MED/99081096; Martal JL; Chene NM; Huynh LP; L'Haridon RM; Reinaud PB; Guillomot MW; Charlier MA; Charpigny SY; Inra, Station de Physiologie animale, Unite Endocrinologie de; l'Embryon, Jouy-en-Josas, France.; IFN-tau (IFN-tau) constitutes a new class of type I IFN which is not virus-inducible, unlike IFN-alpha and IFN-beta, but is constitutively produced by the trophectoderm of the ruminant conceptus during a very short period in early pregnancy. It plays a pivotal role in the mechanisms of maternal recognition of pregnanc
Evaluation of equine infectious anemia virus core proteins produced in a baculovirus expression system in agar gel immunodiffusion test and enzyme-linked immunosorbent assay.: J Vet Med Sci. 1998 Dec;60(12):1361-2. Unique Identifier : AIDSLINE MED/99095614; Kong XG; Pang H; Sugiura T; Matsumoto Y; Onodera T; Akashi H; National Institute of Animal Health, Ibaraki, Japan.; Equine infectious anemia virus (EIAV) core proteins (Gag and p26) obtained from a baculovirus expression system were used in agar gel immunodiffusion (AGID) and enzyme-linked immunosorbent assay (ELISA) antigens to test seventy-six horse sera. Those sera showed false-positive reaction in AGID test using Nisseiken anti
Legal trends in bioethics.: J Clin Ethics. 1998 Winter;9(4):421-30. Unique Identifier : AIDSLINE MED/99154105; Forster HP; Case Western Reserve University School of Medicine, Cleveland,; Ohio, USA.
Phenotypic heterogeneity of PHA-activated CD69+ lymphocytes: the expression of APO-1/FAS antigen (CD95) and perforins identifies different functional subsets.: Eur J Histochem. 1997;41 Suppl 2:117-8. Unique Identifier : AIDSLINE MED/99076907; Rutella S; Rumi C; Lucia MB; Cauda R; Leone G; Center for the Flow Cytometric Study of Blood Cells, Catholic; University, Rome, Italy.
Apoptosis and CD4+, CD8+ lymphocyte depletion following triphenyltin acetate (TPTA) exposure in mice thymic primary culture.: Eur J Histochem. 1997;41 Suppl 2:171-2. Unique Identifier : AIDSLINE MED/99076931; Bollo E; Dacasto M; Cornaglia E; Dipartimento di Patologia Animale, Universita di Torino, Italia.
Flow cytometric evaluation of CD38, CD45 RO and CD45 RA in HIV-infected children.: Eur J Histochem. 1997;41 Suppl 2:193-4. Unique Identifier : AIDSLINE MED/99076941; Caselli D; Comolli G; Maccabruni A; Campisi D; Klersy C; Minoli L; Clinica Pediatrica, IRCCS Policlinico San Matteo, Universita di; Pavia.
Detection of P-glycoprotein efflux activity on peripheral blood lymphocyte subsets from HIV+ patients.: Eur J Histochem. 1997;41 Suppl 2:195-6. Unique Identifier : AIDSLINE MED/99076942; Lucia MB; Rutella S; Rumi C; Ventura G; Caldarola G; Cauda R; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica del Sacro Cuore, Roma, Italy.
CD16+CD56+CD8+ natural killer (NK) cells are decreased during HIV infection.: Eur J Histochem. 1997;41 Suppl 2:197-8. Unique Identifier : AIDSLINE MED/99076943; Lucia MB; Froio N; Tacconelli E; Tumbarello M; Rutella S; Rumi C; Cauda R; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica del Sacro Cuore, Roma, Italy.
Lack of correlation between HLA-DR and CD25 "activation" related antigens on CD16+ NK cells in HIV infection.: Eur J Histochem. 1997;41 Suppl 2:31-2. Unique Identifier : AIDSLINE MED/99076867; Lucia MB; Rutella S; Rumi C; Cauda R; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica del Sacro Cuore, Roma, Italy.
Surface P-glycoprotein expression on peripheral lymphocyte subpopulations from HIV-infected patients.: Eur J Histochem. 1997;41 Suppl 2:33-4. Unique Identifier : AIDSLINE MED/99076868; Lucia MB; Rutella S; Rumi C; Cauda R; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica del Sacro Cuore, Roma, Italy.
Antiphosphatidylserine antibodies in HIV-1+ patients bind apoptotic T cells in vitro.: Eur J Histochem. 1997;41 Suppl 2:65-6. Unique Identifier : AIDSLINE MED/99076883; Cafforio P; Camarda G; Del Prete A; Silvestris F; DIMO, Section of Internal Medicine and Clinical Oncology,; University of Bari.
The differential infectivity and staged progression models for the transmission of HIV.: Math Biosci. 1999 Feb;155(2):77-109. Unique Identifier : AIDSLINE MED/99166046; Hyman JM; Li J; Stanley EA; Theoretical Division, Center for Nonlinear Studies, Los Alamos; National Laboratory, NM 87545, USA.; Recent studies of HIV RNA in infected individuals show that viral levels vary widely between individuals and within the same individual over time. Individuals with higher viral loads during the chronic phase tend to develop AIDS more rapidly. If RNA levels are correlated with infectiousness, these variations explain p
Major liver resection for non-Hodgkin's lymphoma in an HIV-positive patient: report of a case.: Unique Identifier : AIDSLINE MED/99087579; Picciocchi A; Coppola R; Pallavicini F; Riccioni ME; Ciletti S; Marino-Cosentino LM; Marasca G; Ortona L; A very unusual clinical presentation of non-Hodgkin s lymphoma (NHL) of the liver is reported herein. The patient was a 35-year-old male who had been HIV-positive since 1987. Following an episode of acute pain in the right upper abdominal quadrant, ultrasonography (US) and computed
Opportunistic hepatic infections in AIDS patients with fever of unknown origin.: J Formos Med Assoc. 1999 Jan;98(1):5-10. Unique Identifier : AIDSLINE MED/99162754; Chang YG; Chen PJ; Hung CC; Chen MY; Lai MY; Chen DS; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, Taiwan.; The clinical features and histopathologic manifestations of hepatic opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS) in Taiwan remain unexplored. We report 28 AIDS patients (25 men, 3 women; mean a
Disseminated Mycobacterium genavense infection in a patient with acquired immunodeficiency syndrome: first case report in Taiwan.: J Formos Med Assoc. 1999 Jan;98(1):62-5. Unique Identifier : AIDSLINE MED/99162763; Yan JJ; Ko WC; Tsai HM; Jin YT; Su IJ; Department of Pathology, National Cheng Kung University Hospital,; Tainan.; Mycobacterium genavense is a recently described fastidious mycobacterium identified as a pathogen causing disseminated infection in patients with advanced human immunodeficiency virus (HIV) disease. In this report, we describe the first reported case of disseminated M. genavense infection in a patient with acquired im
Short course antiretroviral regimens to reduce maternal transmission of HIV [editorial]: BMJ. 1999 Feb 20;318(7182):479-80. Unique Identifier : AIDSLINE MED/99147876; Wilkinson D; Karim SS; Coovadia HM
[Pneumocystis carinii infections in patients with neoplasms and AIDS--clinical-pathologic changes in the lungs]: Pneumonol Alergol Pol. 1998;66(3-4):207-15. Unique Identifier : AIDSLINE MED/99074993; Slodkowska J; Kaminski Z; Bednarska A; Remiszewski P; Radomski P; Zaleska J; Cholewinska G; Bestry I; Hryniewicz H; Rowinska-Zakrzewska E; Zakladu Patomorfologii, Instytutu Gruzlicy i Chorob Pluc w; Warszawie.; Pneumocystis carinii (PC) has been documented as a cause of pneumonia in a broad range of immunocompromised patients. The presentation of disease will very based on the underlying predisposing condition but a confirmation depends upon the identification of organisms in a bronchial aspiration or lung biopsy specimen. T
Biochemical characterization of recombinant HIV-1 reverse transcriptase (rRT) as a glycyrrhizin-binding protein and the CK-II-mediated stimulation of rRT activity potently inhibited by glycyrrhetinic acid derivative.: Biol Pharm Bull. 1998 Dec;21(12):1282-5. Unique Identifier : AIDSLINE MED/99095966; Harada S; Maekawa T; Haneda E; Morikawa Y; Nagata N; Ohtsuki K; Laboratory of Genetical Biochemistry, Kitasato University School; of Allied Health Sciences, Sagamihara, Japan.; By means of successive Mono Q and glycyrrhizin (GL)-affinity column chromatography (HPLC), recombinant HIV-1 RT (rRT) was purified to apparent homogeneity from the Superdex 200 pg fraction of the crude protein extract of E. coli BL21 transfected with pET 21a(+)/HIV-1 PR-RT. It was found that (i) rRT functioned as an e
Qualitative and quantitative detection of cytomegalovirus DNA in sera by PCR as a clinical marker.: Biol Pharm Bull. 1998 Dec;21(12):1371-5. Unique Identifier : AIDSLINE MED/99095985; Naitou H; Mimaya J; Horikoshi Y; Takashima Y; Amano K; Morita T; Laboratory of Environmental Microbiology, Institute for; Environmental Sciences, University of Shizuoka, Japan.; The amount of human cytomegalovirus ( CMV ) DNA in sera is considered to be a direct marker for CMV infection. We established conditions for nested PCR that detected one copy of CMV DNA, and for competitive PCR, which detected
Cumulative reports of HIV infections in the UK exceed 37,000.: Commun Dis Rep CDR Wkly. 1999 Jan 29;9(5):37. Unique Identifier : AIDSLINE MED/99172710
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 Jan 29;9(5):45-6, 48. Unique Identifier : AIDSLINE MED/99172711
[Acquired immunodeficiency syndrome in Brazil and the State of Ceara]: Sante. 1998 Nov-Dec;8(6):436-9. Unique Identifier : AIDSLINE MED/99164311; Queiroz T; Martins T; Broutet N; Chequer P; Gazin P; Hopital Sao Jose de maladies infectieuses, Fortaleza, Bresil.; Since February 1998, a total of 129,000 cases of acquired immune deficiency syndrome have been reported in Brazil . The cumulative frequency of the disease is 82 per 100,000 which makes Brazil one of the countries moderately affected. There are considerable differences between regio
[HIV-2 infection in the world. A geographical perspective]: Sante. 1998 Nov-Dec;8(6):440-6. Unique Identifier : AIDSLINE MED/99164312; Remy G; Ecole des Hautes Etudes en Sciences Sociales, 2, Marseille.; The geographical distribution of HIV-2 is not fully understood. However, there is enough evidence to speculate about the origins and differentiation of this geographical pattern. Foci of infection probably developed in some African countries, such as Guinea-Bissau ,
HHV8 status in Kaposi's sarcoma associated with multiple myeloma.: Rev Rhum Engl Ed. 1998 Dec;65(12):788-90. Unique Identifier : AIDSLINE MED/99121803; Le Gars L; Agbalika F; Picard O; Kaplan G; Berenbaum F; Rheumatology Department, Saint-Antoine Teaching Hospital, Paris,; France.; Kaposi s sarcoma in its sporadic or HIV-related form is due to a gamma herpesvirus, the human herpes virus 8 (HHV8). No data have been published on the potential role of the HHV8 in Kaposi s sarcoma occurring in multiple myeloma patients. A case is reported of a patient in whom four serum samples taken between the dia
Tuberculosis of the sternoclavicular joint. Report of two cases.: Rev Rhum Engl Ed. 1998 Dec;65(12):791-4. Unique Identifier : AIDSLINE MED/99121804; Bezza A; Niamane R; Benbouazza K; el Maghraoui A; Lazrak N; Kettani M; Missaoui A; Bensabbah R; Rhazali L; Hassouni F; Mohattane A; Hajjaj-Hassouni N; Department of Rheumatology B, El Ayachi Sale Hospital,; Rabat-Sale Teaching Hospital, Morocco.; The sternoclavicular joint accounts for only 1 to 2% of all cases of peripheral tuberculous arthritis and is more often infected by pyogenic organisms than by the tubercle bacillus. We report two cases of sternoclavicular joint tuberculosis, in a 38-year-old man and a 46-year-old woman without risk factors for immune
Adhesive capsulitis of the shoulder induced by protease inhibitor therapy. Three new cases [letter]: Rev Rhum Engl Ed. 1998 Dec;65(12):800-1. Unique Identifier : AIDSLINE MED/99121808; Leone J; Beguinot I; Dehlinger V; Jaussaud R; Rouger C; Strady C; Pennaforte JL; Etienne JC
Psychosocial characteristics of pregnant and nonpregnant HIV-seropositive women.: Psychiatr Serv. 1998 Dec;49(12):1612-4. Unique Identifier : AIDSLINE MED/99072446; Swartz HA; Markowitz JC; Sewell MC; University of Pittsburgh Medical Center, PA, USA.; swartzha@msx.upmc.edu; Thirty-three HIV-positive women, 12 of whom were pregnant, participated in semistructured interviews to define areas of psychosocial need. Eighty-eight percent of the subjects reported current unemployment. A history of substance abuse was reported by 82 percent, suicide attempts by 52 percent, and sexual problems by
[Adult T-cell leukemia/lymphoma]: Ryoikibetsu Shokogun Shirizu. 1998;(22 Pt 3):114-8. Unique Identifier : AIDSLINE MED/99068084; Matsuoka M; Nosaka K; Second Department of Internal Medicine, Kumamoto University; School of Medicine.
[Adult T-cell leukemia not associated with human T-lymphotropic virus type I]: Ryoikibetsu Shokogun Shirizu. 1998;(22 Pt 3):119-21. Unique Identifier : AIDSLINE MED/99068085; Hiruma K; Sasaki T; Transfusion Service, Tokyo Metropolitan Komagome Hospital.
[HTLV-I-associated myelopathy]: Ryoikibetsu Shokogun Shirizu. 1998;(22 Pt 3):122-5. Unique Identifier : AIDSLINE MED/99068086; Hiruma K; Sasaki T; Transfusion Service, Tokyo Metropolitan Komagome Hospital.
[HIV-associated lymphoma]: Ryoikibetsu Shokogun Shirizu. 1998;(22 Pt 3):301-4. Unique Identifier : AIDSLINE MED/99068131; Omine M; Division of Hematology, Internal Medicine, Showa University; Fujigaoka Hospital.
A patient with persistent wheezing, sinusitis, elevated IgE, and eosinophilia [clinical conference]: Ann Allergy Asthma Immunol. 1999 Feb;82(2):144-9. Unique Identifier : AIDSLINE MED/99170910; Robinson J; Ahmed Z; Siddiqui A; Roy T; Berk S; Smith JK; Krishnaswamy G; Division of Allergy and Immunology, East Tennessee State; University, Johnson City, USA.
Interleukin-6 synthesis and IgE overproduction in children with perinatal human immunodeficiency virus-type 1 infection.: Ann Allergy Asthma Immunol. 1999 Feb;82(2):212-6. Unique Identifier : AIDSLINE MED/99170921; de Martino M; Rossi ME; Azzari C; Chiarelli F; Galli L; Vierucci A; Department of Medicine, University of Chieti, Italy.; BACKGROUND: Unbalanced interleukin network and elevated IL-6 synthesis are suggested mechanisms of immunoglobulin overproduction in children with perinatal human immunodeficiency virus-type 1 (HIV-1) infection. OBJECTIVE: To investigate whether elevated IL-6 synthesis is a general mechanism of immunoglobulin overprodu
Intratumoral vaccination of adenoviruses expressing fusion protein RM4/tumor necrosis factor (TNF)-alpha induces significant tumor regression.: Cancer Gene Ther. 1998 Nov-Dec;5(6):371-9. Unique Identifier : AIDSLINE MED/99114130; Wright P; Zheng C; Moyana T; Xiang J; Saskatoon Cancer Center, Department of Microbiology, University; of Saskatchewan, Canada.; Recombinant adenovirus (AdV) vectors are highly efficient at in vitro and in vivo gene delivery. VKCK is a murine myeloma cell line expressing the light chain of the fusion protein RM4/tumor necrosis factor (TNF)-alpha. The in vitro transfection of VKCK cells with the AdV AdV5LacZ, which contains the marker gene beta-
Attitudes and practices of pharmacy managers regarding needle sales to injection drug users.: J Am Pharm Assoc (Wash). 1999 Jan-Feb;39(1):23-6. Unique Identifier : AIDSLINE MED/99143994; Farley TA; Niccolai LM; Billeter M; Kissinger PJ; Grace M; HIV/STD Section, Louisiana Office of Public Health, New Orleans,; USA.; OBJECTIVE: To determine Louisiana pharmacy managers attitudes and practices regarding needle and syringe sales to suspected injection drug users (IDUs) without prescriptions, and to assess which factors affect their decisions to sell nonprescription needles and syringes. DESIGN: Cross-sectional mail survey. SETTING:
Should pharmacists sell sterile syringes to injection drug users?: J Am Pharm Assoc (Wash). 1999 Jan-Feb;39(1):8-10. Unique Identifier : AIDSLINE MED/99143989; Jones TS; Taussig J; Division of HIV/AIDS Prevention-Intervention, Research, and; Support, Centers for Disease Control and Prevention, Atlanta, GA; 30333, USA.tsjl@cdc.gov
Fomiversen sodium approved to treat CMV retinitis.: J Am Pharm Assoc (Wash). 1999 Jan-Feb;39(1):84-5. Unique Identifier : AIDSLINE MED/99144003; Piascik P; University of Kentucky College of Pharmacy, Lexington, USA.
[The immune response in HIV infection and associated diseases of the female genitalia]: Lik Sprava. 1998 Oct-Nov;(7):25-36. Unique Identifier : AIDSLINE MED/99159358; Lakatosh VP; Lazarenko LN; Spivak NIa; Lianenko LA
Selecting antibodies that block the HIV-1 coreceptor [news]: Mol Med Today. 1998 Dec;4(12):507. Unique Identifier : AIDSLINE MED/99084047; Dorrell S
Restoring interleukin 2 production in AIDS patients [news]: Mol Med Today. 1998 Dec;4(12):508. Unique Identifier : AIDSLINE MED/99084048; Dorrell S
T-cell receptor transgenic analysis of tumor-specific CD8 and CD4 responses in the eradication of solid tumors.: Cancer Res. 1999 Mar 1;59(5):1071-9. Unique Identifier : AIDSLINE MED/99168513; Marzo AL; Lake RA; Robinson BW; Scott B; University Department of Medicine, Queen Elizabeth II Medical; Centre, Nedlands, Western Australia, Australia.; The role of tumor-specific CD8 and CD4 lymphocytes in rejecting solid tumors has been difficult to determine because of the lack of models in which tumor antigen, specific CD8 cells, and specific CD4 cells can be monitored and controlled. To investigate the minimal components required for the induction and maintenance
Evidence for involvement of B lymphocytes in the surveillance of lung metastasis in the rat.: Cancer Res. 1999 Mar 1;59(5):1080-9. Unique Identifier : AIDSLINE MED/99168514; Quan N; Zhang Z; Demetrikopoulos MK; Kitson RP; Chambers WH; Goldfarb RH; Weiss JM; Department of Psychiatry and Behavioral Sciences, Emory; University School of Medicine, Atlanta, Georgia 30322, USA.; These studies examined the composition of lymphocytes within the lung after the introduction of tumor cells that metastasize to the lung in rats. i.v. delivery of MADB106 tumor cells into syngeneic Fischer 344 rats caused dose- and time-dependent development of lung tumors, with surface metastases evident 7 days after
Emerging infectious diseases--South Africa.: Emerg Infect Dis. 1998 Oct-Dec;4(4):517-20. Unique Identifier : AIDSLINE MED/99083959; Klugman KP; South African Institute for Medical Research, Johannesburg, South; Africa. KEITHK@mail.saimr.wits.ac.za
Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon.: Emerg Infect Dis. 1998 Oct-Dec;4(4):649-56. Unique Identifier : AIDSLINE +; Pieniazek D; Baggs J; Hu DJ; Matar GM; Abdelnoor AM; Mokhbat JE; Uwaydah M; Bizri AR; Ramos A; Janini LM; Tanuri A; Fridlund C; Schable C; Heyndrickx L; Rayfield MA; Heneine W; HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB; Laboratory Research, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA. dxp1@cdc.gov; HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon . Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were cl
Development of an in vitro assay system for screening of gp41 inhibitory compounds.: Mol Cells. 1998 Dec 31;8(6):717-23. Unique Identifier : AIDSLINE MED/99110416; Ryu JR; Lee J; Choo S; Yoon SH; Woo ER; Yu YG; Structural Biology Center, Korea Institute of Science and; Technology, Seoul.; The transmembrane protein of HIV-1, gp41, mediates fusion between membranes of the virus and target cell. Strong interaction between the helical regions in the ectodomain of gp41 has been exploited to develop a method that can detect a potential inhibitor against gp41. The N-terminus coiled-coil or the C-terminus heli
Possible biological indicators of the response to recombinant tumour necrosis factor alpha in patients with advanced neoplasms.: J Exp Clin Cancer Res. 1998 Sep;17(3):349-54. Unique Identifier : AIDSLINE MED/99110065; Braczkowski R; Zubelewicz B; Romanowski W; Lissoni P; Brivio F; 5th Dept. of Internal Medicine, Silesian Medical School, Bytom,; Poland.; Tumour Necrosis Factor alpha (TNF alpha) immunotherapy, in addition to that of Interleukin-2 immunotherapy, represents one of the most promising biotherapies for human neoplasms. In order to identify immunological parameters of prognostic value we studied changes in immune response during first cycle of treatment with
Human chorionic gonadotropin as a target for cancer vaccines.: Oncol Rep. 1999 Jan-Feb;6(1):7-17. Unique Identifier : AIDSLINE MED/99085105; Triozzi PL; Stevens VC; The Ohio State University Comprehensive Cancer Center, The Arthur; G. James Cancer Hospital and Research Institute, Columbus, OH; 43210, USA.; Human chorionic gonadotropin (hCG) is expressed by common cancers and may play a role in cell transformation as well as angiogenic, metastatic, and immune escape phenomena that are central to cancer progression. Clinical trials with a vaccine targeting the carboxy-terminal peptide of -hCG have indicated that tolerance
Graft-versus-leukemia reactivity involves cluster formation between superantigen-reactive donor T lymphocytes and host macrophages.: Clin Cancer Res. 1998 Dec;4(12):3095-106. Unique Identifier : AIDSLINE MED/99081524; Muerkoster S; Wachowski O; Zerban H; Schirrmacher V; Umansky V; Rocha M; Deutsches Krebsforschungszentrum, Abteilung Zellulare; Immunologie, FSP Tummorimmunologie, Heidelberg, Germany.; T-cell-mediated antitumor effects play an important role clinically in allogeneic graft-versus-leukemia (GvL) reactivity, whereas T-cell-mediated antihost effects are associated with a risk of developing graft-versus-host (GvH) disease. GvL and GvH were compared in an animal tumor model system after the systemic trans
Sexually transmitted diseases in 1161 HIV-positive patients: a 38-month prospective study in southern Spain.: J Eur Acad Dermatol Venereol. 1998 Nov;11(3):221-6. Unique Identifier : AIDSLINE MED/99099886; Munoz-Perez MA; Rodriguez-Pichardo A; Camacho Martinez F; Department of Dermatology, Virgen Macarena Hospital, School of; Medicine of Sevilla, Spain.; BACKGROUND: HIV infection is primarily a sexually transmitted disease (STD), but intravenous drug use (IDU) is the main risk factor for HIV infection in certain areas, including southern Europe. A number of prospective studies of dermatological findings in HIV-1 infected patients have been published, almost all from c
Efficacy and tolerance of oral ivermectin in scabies.: J Eur Acad Dermatol Venereol. 1998 Nov;11(3):247-51. Unique Identifier : AIDSLINE MED/99099890; Dourmishev A; Serafimova D; Dourmishev L; Department of Dermatology and Venereology, Medical University,; Sofia, Bulgaria. ald@medun.acad.bg; OBJECTIVE: The aim of this open-label study was to investigate the therapeutic effect and adverse reactions of oral ivermectin in scabies patients. BACKGROUND: There is much confusion over reports of efficacy, adverse reactions and relapses after oral treatment of scabies with ivermectin. METHODS: Nineteen patients, t
Pneumococcal pneumonia associated with perianal herpes simplex virus type 2 in a HIV seropositive patient [letter]: J Eur Acad Dermatol Venereol. 1998 Nov;11(3):257-8. Unique Identifier : AIDSLINE MED/99099892; Clarke S; Merry C; Moran AM; Mulcahy F
[Spontaneous resolution of pulmonary cryptococcosis--report of 2 cases]: Nihon Kokyuki Gakkai Zasshi. 1998 Oct;36(10):902-7. Unique Identifier : AIDSLINE MED/99109313; Kakeya H; Abe K; Yoshinaga M; Ishii H; Tomiyama Y; Maesaki S; Kadota J; Tomono K; Tashiro T; Kohno S; Second Department of Internal Medicine, Nagasaki University; School of Medicine, Japan.; We encountered two patients with pulmonary cryptococcosis that resolved spontaneously without antifungal treatment. A 59-year-old man (patient 1) and 37-year-old man (patient 2) were admitted to our hospital for the examination of abnormal shadows on their chest x-ray films. Transbronchial lung biopsies were performed
Detection and sequence diversity of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) DNA.: Eur J Dermatol. 1999 Jan-Feb;9(1):13-6. Unique Identifier : AIDSLINE MED/99121165; Murakami M; Sugita Y; Ishii N; Nagatani T; Ichiyama S; Tamura N; Mohri S; Nakajima H; Department of Dermatology, Yokohama City, University School of; Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.; Detection of Kaposi s sarcoma (KS)-associated herpesvirus (KSHV)/human herpesvirus (HHV-8) has been reported frequently in patients with KS associated with acquired immunodeficiency syndrome (AIDS). We examined the presence of the KSHV sequence in 8 HIV-positive patients comprising 5 with KS, 2 with syphilis, 1 with p
Contact dermatitis I. Pathophysiology of contact sensitivity.: Eur J Dermatol. 1999 Jan-Feb;9(1):65-77. Unique Identifier : AIDSLINE MED/99121178; Krasteva M; Kehren J; Ducluzeau MT; Sayag M; Cacciapuoti M; Akiba H; Descotes J; Nicolas JF; INSERM U. 503, Faculte de Medecine Lyon RTH Laennec, rue; Guillaume-Paradin, 69372 Lyon Cedex 08, France.
Efficient synthesis of N-4 alkyl derivatives of 2',3'-dideoxycytidine (ddC).: Nucleosides Nucleotides. 1999 Jan;18(1):1-4. Unique Identifier : AIDSLINE MED/99191719; Dechaux E; Pontikis R; Monneret C; Institut Curie, Section Recherche, UMR 176 CNRS-IC, Paris,; France.; The C-4 triisopropylphenylsulfonyl (TPS) group of the 2,3-dideoxyuridine derivative 2 is readily displaced in situ by nitrogen nucleophiles forming N-4 substituted ddC in acceptable yields.
Synthesis and anti-HIV activity of different novel nonclassical nucleosides.: Nucleosides Nucleotides. 1999 Jan;18(1):113-23. Unique Identifier : AIDSLINE MED/99157787; Elgemeie GE; Mansour OA; Metwally NH; Chemistry Department, Faculty of Science, Helwan University,; Cairo, Egypt.; A series of different novel nonclassical nucleosides have been synthesised and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells.
Synthesis of 2'-methylene-substituted 5-azapyrimidine, 6-azapyrimidine, and 3-deazaguanine nucleoside analogues as potential antitumor/antiviral agents.: Nucleosides Nucleotides. 1999 Jan;18(1):55-72. Unique Identifier : AIDSLINE MED/99157783; Liu MC; Luo MZ; Mozdziesz DE; Lin TS; Dutschman GE; Cheng YC; Sartorelli AC; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06520-8066, USA.; 2 -Deoxy-2 -methylene-6-azauridine (5) and 2 -deoxy-2