1999

Double gloving and a glove perforation indication system during the dental treatment of HIV-positive patients: are they necessary?: Br Dent J. 1999 Jan 9;186(1):27-9. Unique Identifier : AIDSLINE MED/99153115; Avery CM; Gallagher P; Birnbaum W; Department of Oral and Maxillofacial Surgery, King's College; Hospital, London.; AIM: The aim of this study was to compare the incidence of glove perforation when double gloved or single gloved during the routine treatment of HIV-positive patients. In addition, a glove perforation indication system based on a double gloving technique was assessed. DESIGN: Prospective, randomised and open study of
Hyperlipidaemia following treatment with protease inhibitors in patients with HIV-1 infection [letter]: Br J Clin Pharmacol. 1998 Nov;46(5):518-9. Unique Identifier : AIDSLINE MED/99049354; Churchill DR; Pym AS; Babiker AG; Back DJ; Weber JN
Phase III results of second-generation HIV protease inhibitor reported [news]: Oncology (Huntingt). 1998 Nov;12(11):1616. Unique Identifier : AIDSLINE MED/99052004
Lower genital tract neoplasia in women with HIV infection.: Oncology (Huntingt). 1998 Dec;12(12):1735-9; discussion 1742, 1745, 1747. Unique Identifier : AIDSLINE MED/99092006; Abercrombie PD; Korn AP; UCSF Department of Obstetrics, Gynecology, and Reproductive; Sciences, San Francisco General Hospital, California, USA.; Women who are infected with human immunodeficiency virus (HIV) are at greater risk for the development of lower genital tract neoplasia than are HIV-negative women. Among HIV-positive women, those who are more severely immunosuppressed appear to be at higher risk for cervical intraepithelial neoplasia (CIN), also know
Non-human immunodeficiency virus Kaposi's sarcoma can be effectively treated with low-dose interferon-alpha despite the persistence of herpesvirus-8.: Br J Dermatol. 1998 Dec;139(6):1052-4. Unique Identifier : AIDSLINE MED/99144182; Deichmann M; Thome M; Jackel A; Utermann S; Bock M; Waldmann V; Naher H; Department of Dermatology, Universitatsklinikum Heidelberg,; Germany.; Three patients, negative for human immunodeficiency virus (HIV), with histologically and polymerase chain reaction-proven non-HIV Kaposi s sarcoma who received low-dose interferon (IFN) as first-line treatment because of disseminated symptomatic disease are reported. Applying 3-18 million IU of IFN-alpha 2a per day, 3
Cutaneous mucinoses and HIV infection.: Br J Dermatol. 1998 Dec;139(6):1077-80. Unique Identifier : AIDSLINE MED/99144188; Rongioletti F; Ghigliotti G; De Marchi R; Rebora A; Department of Dermatology, University of Genoa, Italy.; In the last few years cutaneous mucinoses have been reported with increased frequency in HIV patients. We report the occurrence of scleredema, reticular erythematous mucinosis and lichen myxoedematosus in three different HIV-infected patients, review the literature and discuss the possible relationship between mucin d
Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression.: Hum Gene Ther. 1998 Nov 20;9(17):2459-68. Unique Identifier : AIDSLINE MED/99068402; Fassati A; Bardoni A; Sironi M; Wells DJ; Bresolin N; Scarlato G; Hatanaka M; Yamaoka S; Dickson G; Department of Biochemistry, Royal Holloway College, University of; London, Egham, Surrey, United Kingdom.; The use of retroviral vectors (RVs) derived from the murine oncoretroviruses for gene therapy is associated with the risk of malignant transformation of infected cells and ectopic expression of the proteins of interest. Targeting retroviral vectors to specific tissues would increase their safety and clinical applicabi
[Nutritional status of patients with HIV-AIDS infection (editorial)]: An Med Interna. 1998 Dec;15(12):623-6. Unique Identifier : AIDSLINE MED/99138541; Lopez-Herce JA
[Evolution of the nutritional status of patients with HIV-AIDS. Effects of socioeconomic situation and dietetic counseling]: An Med Interna. 1998 Dec;15(12):627-32. Unique Identifier : AIDSLINE MED/99138542; Sanchez Alvarez MC; Gomez Ramos MJ; Cano Sanchez A; Pacheco Guevara R; Nicolas Hernandez M; Garcia Alberola A; S. Medicina Intensiva-Unidad de Nutricion, Hospital General; Universitario, Murcia.; OBJECTIVES: To know HIV-AIDS patient s nutritional status in different infection s condition and their relation with the socioeconomic situation and, in that case, the nutritional condition improvement through the dietetic advice appropriated for each patient. METHODS: Prospective study of 79 patients with HIV-AIDS di
[Impact of HIV infection in hospital environment]: An Med Interna. 1998 Dec;15(12):633-7. Unique Identifier : AIDSLINE MED/99138543; Martinez Aviles P; Lopez Benito I; Berbegal Serra J; Servicio de Medicina Interna, Hospital Marina Alta, Denia,; Alicante.; OBJECTIVE: Retrospective study to review the admissions at the Hospital Marina Alta due to infection for HIV or its complications and look for risk factors. METHODS: Clinical charts of patients admitted at the hospital from 1989 to 1996 were analyzed. RESULTS: From 11,932 admissions, 199 (1.7%) were due to patients wi
[Study of histoenzymatic activity of isocitrate-DH in the hepatic tissue of rats treated with AZT: image analysis]: An Med Interna. 1998 Dec;15(12):638-41. Unique Identifier : AIDSLINE MED/99138544; Corcuera Pindado MT; Carbajo Perez S; Gomez Aguado F; Roldan Contreras M; Picazo Talavera A; Alonso Martin MJ; Servicio de Anatomia Patologica, Instituto de Salud Carlos III,; Madrid.; OBJECTIVE: Recently has been described alterations in different organs of HIV + patients treated with zidovudine ( AZT ), as secondary effect from drug administration. METHOD: We have developed and experimental rat model, in which the rats were administ
[Value of quantification of p24 antigen in plasma as a prognostic marker of survival in a cohort of 251 HIV-positive patients]: An Med Interna. 1998 Dec;15(12):647-9. Unique Identifier : AIDSLINE MED/99138546; Rubio Caballero M; Nogues Biau A; Falguera Sacrest M; Puig Gatnau T; Lorente L; Servicio de Medicina Interna, Hospital Universitario Arnau de; Vilanova, Lleida.; OBJECTIVE: To analyse plasma p24 antigen as a marker of survival in a cohort of HIV-infected patients whose time of seroconversion is unknown. DESIGN: Prospective cohort study. SETTING: AIDS Unit in a teaching hospital. PATIENTS: 251 patients were studied, most on antiretroviral therapy. Mean initial CD4 cell counts w
[Mucocutaneous manifestations in acute HIV infection. 3 case reports]: An Med Interna. 1998 Dec;15(12):650-3. Unique Identifier : AIDSLINE MED/99138547; Barnadas MA; Margall N; Rabella N; Alegre M; Baselga E; Randazzo L; de Moragas JM; Servicio de Dermatologia, Hospital de la Santa Creu i Sant Pau,; Barcelona.; We report three patients who developed a generalized rash with oral, genital or perianal ulcerations as a result of acute infection due to HIV. The primary infection was diagnosed by seroconversion (by means of EIA and Western blot techniques). Definitive diagnosis was established on days 52, 85 and 97 after the appea
[Pulmonary cryptosporidiosis and AIDS (letter)]: An Med Interna. 1998 Dec;15(12):672. Unique Identifier : AIDSLINE MED/99138554; Garcinuno Jimenez MA; Serrano-Heranz R; Barragan Casas JM; Moran Becares AY
Flow cytometric analysis of intracellular interferon-gamma synthesis in rat CD4 T cells.: Eur Cytokine Netw. 1998 Dec;9(4):613-8. Unique Identifier : AIDSLINE MED/99107682; Bernard I; Foucras G; Cautain B; van der Meide PH; Druet P; Guery JC; Saoudi JC; INSERM U. 28, place du Dr.-Baylac, 31059 Toulouse Cedex, France.; To date the techniques used to analyse cytokine expression by rat T cells do not give information about the simultaneous production of different cytokines from individual cells. Recently, a method for analysing the intracellular production of cytokines at the single cell level using flow cytometry has been developed.
[AIDS-related cancers]: Bull Cancer. 1999 Jan;86(1):53-6. Unique Identifier : AIDSLINE MED/99155365; Blay JY; Bouhour D; Unite cytokine et cancer, Inserm U. 453, Centre Leon-Berard,; 28, rue Laennec, 69008 Lyon, France.
Protease inhibitors in HIV infection. Lipodystrophy may be a consequence of prolonged survival [letter]: BMJ. 1999 Jan 9;318(7176):122. Unique Identifier : AIDSLINE MED/99096749; Buss N; Duff F
US considers name based tracking for HIV positive patients [news]: BMJ. 1999 Jan 9;318(7176):75. Unique Identifier : AIDSLINE MED/99096721; Ciment J
Medical students, their electives, and HIV [editorial; comment]: BMJ. 1999 Jan 16;318(7177):139-40. Unique Identifier : AIDSLINE MED/99105842; Wilkinson D; Symon B
Medical students' risk of infection with bloodborne viruses at home and abroad: questionnaire survey [see comments]: BMJ. 1999 Jan 16;318(7177):158-60. Unique Identifier : AIDSLINE MED/99105866; Gamester CF; Tilzey AJ; Banatvala JE; Guy's, King's College, and St Thomas's School of Medicine, St; Thomas's Campus, London SE1 7EH.; OBJECTIVE: To determine risks of exposure to and prevention of bloodborne virus infections among medical students during their elective period. DESIGN: Questionnaire study of students returning from their electives in 1997-8. SETTING: Urban teaching hospital. SUBJECTS: 220 final year medical students. RESULTS: 148 stu
Provision of health advice for UK medical students planning to travel overseas for their elective study period: questionnaire survey [see comments]: BMJ. 1999 Jan 16;318(7177):161-2. Unique Identifier : AIDSLINE MED/99105867; Moss PJ; Beeching NJ; Division of Tropical Medicine, Liverpool School of Tropical; Medicine, Liverpool L3 5QA.
Sexual lifestyle of long distance lorry drivers in India: questionnaire survey.: BMJ. 1999 Jan 16;318(7177):162-3. Unique Identifier : AIDSLINE MED/99105868; Rao KS; Pilli RD; Rao AS; Chalam PS; AIDS Prevention Division, Child Foundation of India,; Visakhapatnam 530 008, Andhra Pradesh, India.
Abdominal findings in AIDS-related pulmonary tuberculosis correlated with associated CD4 levels [see comments]: Abdom Imaging. 1998 Nov-Dec;23(6):573-7. Unique Identifier : AIDSLINE MED/99119249; Solomon A; Feldman C; Kobilski SA; Department of Diagnostic Radiology, University of Witwatersrand,; Parktown, South Africa.; BACKGROUND: To document the abdominal manifestations of tuberculosis (TB) associated with human immunodeficiency virus (HIV) infection and to correlate those findings with CD4 levels. METHODS: Twenty-nine HIV-positive patients with culture-proven Mycobacterium tuberculosis infection were entered into the study. Chest
Abdominal findings in AIDS-related pulmonary tuberculosis correlated with associated CD4 levels [comment]: Abdom Imaging. 1998 Nov-Dec;23(6):578-9. Unique Identifier : AIDSLINE MED/99119250; Wall SD; Edinburgh KJ; Department of Radiology, University of California, San Francisco; 94121, USA.
HTLV-I infection among relatives of patients with adult T-cell leukemia/lymphoma in Brazil: analysis of infection transmission.: Leuk Lymphoma. 1998 Oct;31(3-4):411-6. Unique Identifier : AIDSLINE MED/99084551; Borducchi DM; Oliveira JS; Bordin JO; Kerbauy J; The Hematology and Transfusion Medicine Service-Universidade; Federal de Sao Paulo, Escola Paulista de Medicina, Brazil.; We examined the presence of HTLV-I infection among 66 family members of 13 patients with well documented ATL to investigate the routes of HLTV-I transmission in a Southeast region of Brazil . HTLV-I infection was screened by an enzyme immunossay (ELISA) test and all repeatedly posit
Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium.: Protein Sci. 1998 Dec;7(12):2669-74. Unique Identifier : AIDSLINE PDB/R1WJEMR; Cai M; Huang Y; Caffrey M; Zheng R; Craigie R; Clore GM; Gronenborn AM; Laboratory of Chemical Physics, National Institute of Diabetes; and Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0520, USA.; The solution structure of His12 --> Cys mutant of the N-terminal zinc binding domain (residues 1-55; IN(1-55)) of HIV-1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very similar to that of the wild-type N-terminal domain complexed to zinc.
Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds.: Biol Pharm Bull. 1998 Nov;21(11):1154-9. Unique Identifier : AIDSLINE MED/99068293; Hayakawa Y; Fujii H; Hase K; Ohnishi Y; Sakukawa R; Kadota S; Namba T; Saiki I; Department of Pathogenic Biochemistry, Research Institute for; Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.; We have investigated the anti-metastatic effect of Celosia argentea seed extracts (CAE), which have traditionally been used as a therapeutic drug for eye and hepatic diseases in China and Japan . Intraperitoneal (i.p.) administration of CAE for 7 d
Minimizing HIV/AIDS malnutrition.: Medsurg Nurs. 1998 Oct;7(5):256-67; quiz 268-9. Unique Identifier : AIDSLINE MED/99155452; Keithley JK; Swanson B; Rush University College of Nursing, Chicago, IL, USA.; HIV/AIDS malnutrition influences immune function, disease progression, and quality of life. Changes in dietary intake, altered metabolism, and malabsorption are among the mechanisms that contribute to the nutritional alterations seen in HIV/AIDS. Medical-surgical nurses can help their patients minimize HIV/AIDS malnut
[Questions about sexual ethics related to AIDS]: Contracept Fertil Sex. 1998 Nov;26(11):812-8. Unique Identifier : AIDSLINE MED/99082408; Colpin H; Centre de Reference Sida-ULB, CHU Saint-Pierre, Bruxelles,; Belgique.; The discovery of Aids has profoundly interfered with the sexual behaviour, perceptions and discourse. It has provoked new questions in the field of sexual ethics, some of which are presented and discussed here: safer sex, partner notification, child wish and the attitude of society towards Aids. Finally a discussion o
New UK guidance on the prevention and control of transmission of HIV related and drug resistant tuberculosis.: Commun Dis Rep CDR Wkly. 1999 Feb 5;9(6):49. Unique Identifier : AIDSLINE MED/99148891
Proton MR spectroscopy in inflammatory and infectious brain disorders.: Neuroimaging Clin N Am. 1998 Nov;8(4):863-80. Unique Identifier : AIDSLINE MED/98443341; Cecil KM; Lenkinski RE; Department of Radiology, MR Section, University of Pennsylvania,; Philadelphia 19104, USA. kim@mrssparc.mri.upenn.edu; This article reviews the proton MR spectroscopy literature regarding brain infarction and inflammatory diseases. We examine the salient findings reported for bacterial abscesses, intracranial tuberculomas, Creutzfeldt-Jakob disease, herpes simplex encephalitis and HIV. These processes demonstrate specific metabolic pr
Evidence for a synergistic effect of the HIV-1 envelope protein gp120 and brain-derived neurotrophic factor (BDNF) leading to enhanced expression of somatostatin neurons in aggregate cultures derived from the human fetal cortex.: Brain Res. 1999 Jan 9;815(2):349-57. Unique Identifier : AIDSLINE MED/99096587; Barnea A; Roberts J; Ho RH; Department of Obstetrics and Gynecology, The University of Texas; Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd.,; Dallas, TX 75235-9032, USA. abarn1@mednet.swmed.edu; Changes in the expression of somatostatin (SRIF) have been observed in the brains of HIV encephalitis. Since gp120 is thought to play a major role in AIDS-associated abnormalities in the brain, we addressed the question: Does gp120 alter the functional expression of human fetal SRIF neurons in culture and if so, is th
Neurotoxicity of FIV and FIV envelope protein in feline cortical cultures.: Brain Res. 1999 Jan 23;816(2):431-7. Unique Identifier : AIDSLINE MED/99096653; Bragg DC; Meeker RB; Duff BA; English RV; Tompkins MB; Curriculum in Neurobiology and Department of Neurology,; University of North Carolina, Chapel Hill, NC 27599, USA.; The neurotoxic effects of the feline immunodeficiency virus (FIV) and FIV envelope proteins were measured in primary cultures of feline cortical neurons. Envelope protein from the FIV-PPR strain promoted neuronal swelling and death, whereas envelope protein from the FIV-34TF10 isolate produced intermediate or negligib
Occupational exposure to HIV: experience at a tertiary care center.: J Occup Environ Med. 1998 Dec;40(12):1102-9. Unique Identifier : AIDSLINE MED/99089053; Swotinsky RB; Steger KA; Sulis C; Snyder S; Craven DE; Department of Medicine, Boston University School of Medicine,; Mass, USA.; We examined our hospital-based occupational health clinic s experience with combination antiretroviral therapy for postexposure prophylaxis for human immunodeficiency virus (HIV). Over a 12-month period, 68 workers started postexposure prophylaxis: 23 with zidovudine and lamivudine and 45 with zidovudine, lamivudine,
[Acquired immunodeficiency syndrome]: Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):269-72. Unique Identifier : AIDSLINE MED/99050683; Kawano F; Sanada I; Institute for Clinical Research, Kumamoto National Hospital.
[Job's syndrome]: Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):76-8. Unique Identifier : AIDSLINE MED/99050627; Asano Y; Niho Y; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University.
Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients.: Eur J Oral Sci. 1998 Dec;106(6):979-85. Unique Identifier : AIDSLINE MED/99094517; Grimoud AM; Arnaud C; Dellamonica P; Lodter JP; Laboratory for Oro-Facial Biology, Faculty of Dentistry, Toulouse; III University and Hotel Dieu, University Hospital, France.; doydenta@adm.ups-tlse.fr; The objective of this study was to determine the relationships between saliva protein concentrations, oral mucosal lesions, and systemic parameters in HIV positive patients and controls. Twenty-three control volunteers and 58 HIV-antibody positive patients received a complete oral examination and medical evaluation. I
Angiocentric CD3(+) T-cell infiltrates in human immunodeficiency virus type 1-associated central nervous system disease in children.: Clin Diagn Lab Immunol. 1999 Jan;6(1):105-14. Unique Identifier : AIDSLINE MED/99091889; Katsetos CD; Fincke JE; Legido A; Lischner HW; de Chadarevian JP; Kaye EM; Platsoucas CD; Oleszak EL; Department of Microbiology and Immunology, St. Christopher's; Hospital for Children and Allegheny University of the Health; Sciences, Philadelphia, Pennsylvania, USA.; A significant proportion of brain tissue specimens from children with AIDS show evidence of vascular inflammation in the form of transmural and/or perivascular mononuclear-cell infiltrates at autopsy. Previous studies have shown that in contrast to inflammatory lesions observed in human immunodeficiency virus type 1 (
Giant syncytia and virus-like particles in ovarian carcinoma cells isolated from ascites fluid.: Clin Diagn Lab Immunol. 1999 Jan;6(1):115-26. Unique Identifier : AIDSLINE MED/99091890; Rakowicz-Szulczynska EM; McIntosh DG; Smith ML; Departments of Obstetrics and Gynecology, University of Nebraska; Medical Center, Omaha, Nebraska 68198-3255, USA.; emrakoii@unmc.edu; Ovarian cancer cells were isolated from ascites fluid of 30 different patients diagnosed with cystadenocarcinoma of ovaries. Large colonies of malignant ASC cells were observed during the first week of cell growth in vitro. Colony formation was followed by fusion of cells and formation of large multinucleated and high
Viability and recovery of peripheral blood mononuclear cells cryopreserved for up to 12 years in a multicenter study.: Clin Diagn Lab Immunol. 1999 Jan;6(1):14-9. Unique Identifier : AIDSLINE MED/99091873; Kleeberger CA; Lyles RH; Margolick JB; Rinaldo CR; Phair JP; Giorgi JV; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, Maryland 21205, USA. ckleeber@jhsph.edu; The Multicenter AIDS Cohort Study (MACS), an ongoing prospective study of the natural history of human immunodeficiency virus (HIV), has stored biologic specimens, including peripheral blood mononuclear cells (PBMC), from 5,622 participants for up to 12 years. The purpose of the present analysis was to evaluate the qu
Incidence of human immunodeficiency virus antibody in a prenatal population at a community hospital.: Clin Diagn Lab Immunol. 1999 Jan;6(1):140-1. Unique Identifier : AIDSLINE MED/99091895; Alexander TS; Lee J; Yen-Lieberman B; Department of Pathology and Laboratory Medicine, Summa Health; System, Akron, Ohio 44304, USA. alexandt@summa-health.org; Prenatal human immunodeficiency virus (HIV) screening may reduce vertical HIV transmission. We screened 4,419 prenatal sera and found 38 repeatedly reactive specimens with an HIV-1-HIV-2 enzyme-linked immunosorbent assay. Western blot analysis confirmed four of these specimens as positive for HIV-1 antibodies. Screeni
Immune determinants of organism and outcome in febrile hospitalized Thai patients with bloodstream infections.: Clin Diagn Lab Immunol. 1999 Jan;6(1):73-8. Unique Identifier : AIDSLINE MED/99091883; Jason J; Archibald L; McDonald LC; Hart WM; Rheanppumikankit S; Tansuphwaswadikul S; Byrd MG; Larned J; Han A; Green TA; Jarvis WR; Immunology Branch, Sexually Transmitted Diseases, and; Tuberculosis Laboratory Research, National Center for Infectious; Diseases Centers for Disease Control and Prevention, Public; Health Service, Atlanta, Georgia 30333, USA. JMJ1@CDC.gov; Opportunistic infections (OI) and the human immunodeficiency virus (HIV) cause significant morbidity and mortality in developing countries. Immune cell and cytokine profiles may be related to the type and course of OI and to the OI-HIV interaction. Examining cell-specific cytokine production ex vivo has only recently
Variables that affect assays for plasma cytokines and soluble activation markers.: Unique Identifier : AIDSLINE MED/99091886
Potentiation of E7 antisense RNA-induced antitumor immunity by co-delivery of IL-12 gene in HPV16 DNA-positive mouse tumor.: Gene Ther. 1998 Nov;5(11):1462-71. Unique Identifier : AIDSLINE MED/99129160; He YK; Lui VW; Baar J; Wang L; Shurin M; Almonte C; Watkins SC; Huang L; Department of Pharmacology, University of Pittsburgh, School of; Medicine, PA 15261, USA.; Down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied, and in some cases, therapeutic effects have been demonstrated. We have previously shown that down-regulation of HPV16 E6 and E7 gene expression inhibited HPV DNA-positive C3 mouse tumor growth. Although not all of the
Shapes of MHC restriction.: Immunity. 1999 Jan;10(1):1-7. Unique Identifier : AIDSLINE MED/99146370; Garboczi DN; Biddison WE; Structural Biology Section, National Institute of Allergy and; Infectious Diseases, Rockville, Maryland 20852-1727, USA.; dgarboczi@atlas.niaid.nih.gov
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.: Immunity. 1999 Jan;10(1):127-36. Unique Identifier : AIDSLINE GENBANK/AF110460; Novick D; Kim SH; Fantuzzi G; Reznikov LL; Dinarello CA; Rubinstein M; Department of Molecular Genetics, Weizmann Institute of Science,; Rehovot, Israel.; An interleukin-18 binding protein (IL-18BP) was purified from urine by chromatography on IL-18 beads, sequenced, cloned, and expressed in COS7 cells. IL-18BP abolished IL-18 induction of interferon-gamma (IFNgamma), IL-8, and activation of NF-kappaB in vitro. Administration of IL-18BP to mice abrogated circulating IFN
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.: Immunity. 1999 Jan;10(1):39-49. Unique Identifier : AIDSLINE MED/99146374; Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I; Akira S; Department of Biochemistry, Hyogo College of Medicine,; Nishinomiya, Japan.; We have generated mice with a cell type-specific disruption of the Stat3 gene in macrophages and neutrophils. The mutant mice are highly susceptible to endotoxin shock with increased production of inflammatory cytokines such as TNF alpha, IL-1, IFN gamma, and IL-6. Endotoxin-induced production of inflammatory cytokine
RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.: Unique Identifier : AIDSLINE MED/99146379; Song A; Chen YF; Thamatrakoln K; Storm TA; Krensky AM; Department of Pediatrics, Stanford University School of Medicine,; California 94305-5208, USA.; RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression clo
[Effect of HIV envelope glycoprotein on the induction of immune dysregulation in HIV infection]: Nihon Rinsho Meneki Gakkai Kaishi. 1998 Feb;21(1):11-9. Unique Identifier : AIDSLINE MED/99100284; Sekigawa I; Akimoto H; Kaneko H; Department of Medicine, Juntendo Izu-Nagaoka Hospital, Juntendo; University School of Medicine.; The envelope glycoprotein of human immunodeficiency virus (HIV) has been know to play an important role in the induction of immune dysregulation of HIV infection. Recent evidence suggests that HIV requires the chemokine receptors as a coreceptor. In addition, we found that HIV-2 (but not HIV-1) envelope glycoprotein c
Bacterial extract OM85-BV induces interleukin-12-dependent IFN-gamma production by human CD4+ T cells.: J Interferon Cytokine Res. 1998 Oct;18(10):817-21. Unique Identifier : AIDSLINE MED/99025488; Byl B; Libin M; Gerard M; Clumeck N; Goldman M; Mascart-Lemone F; Department of Immunology, Hopital Erasme, Brussels, Belgium.; To obtain insight into the possible mode of action of bacterial extracts used as immunostimulants in Europe, we used the ELISPOT technique to investigate the effects of one of them (OM85-BV, Broncho-Vaxom) on interferon-y (IFN-gamma) production by peripheral blood mononuclear cells (PBMC). We found that (1) OM85-BV st
[Incidence and clinical features of splenic abscesses, with special reference to tuberculous etiology in a general hospital]: Gastroenterol Hepatol. 1998 Dec;21(10):479-82. Unique Identifier : AIDSLINE MED/99126753; Arruabarrena I; Bermejo MC; Ojeda E; Cosme A; Garmendia G; Servicio de Medicina Interna, Hospital Nuestra Senora de; Aranzazu, San Sebastian.; BACKGROUND: The aim of this revision is to know the incidence of splenic abscess (SA) in our hospital, its etiology, with special reference to tuberculosis, and clinical characteristics. PATIENTS AND METHODS: Abdominal CT-scan performed during the period 1987-1997, with the diagnosis of splenic abscess were reviewed.
[How should a patient with chronic hepatitis C be advised?]: Gastroenterol Hepatol. 1998 Nov;21(9):459-63. Unique Identifier : AIDSLINE MED/99099392; Bruguera M; Hospital Clinic i Provincial, Departamento de Medicina, Facultad; de Medicina, Universidad de Barcelona.
Changes in mortality, arrests, and hospitalizations in nonvoluntarily treated heroin addicts in relation to methadone treatment.: Subst Use Misuse. 1998 Dec;33(14):2803-17. Unique Identifier : AIDSLINE MED/99084790; Fugelstad A; Agren G; Romelsjo A; Center for Dependency Disorders of St. Goran's Hospital,; Stockholm, Sweden.; This study analyzes the mortality, hospitalizations, and arrests in a cohort of severe intravenous heroin users divided into three groups: those in methadone treatment, those discharged from treatment, and those who never received treatment. The study population consists of 101 heroin users, of whom 56 were HIV-seropo
The impact of methadone on consumption of inpatient care and mortality, with special reference to HIV status.: Subst Use Misuse. 1998 Dec;33(14):2819-34. Unique Identifier : AIDSLINE MED/99084791; Stenbacka M; Leifman A; Romelsjo A; Department of Clinical Neuroscience, Center for Clinic of; Dependence Disorders, Karolinska Institute, Stockholm, Sweden.; This study investigates the impact of methadone treatment on inpatient care admissions and mortality among 331 methadone-maintained patients compared with 1,483 similar untreated opiate misusers. The methadone patients manifested a lower mortality during treatment than the comparison group and those patients who had l
Induction of the chemokine beta peptides, MIP-1 alpha and MIP-1 beta, by lipopolysaccharide is differentially regulated by immunomodulatory cytokines gamma-IFN, IL-10, IL-4, and TGF-beta.: Mol Med. 1998 Oct;4(10):648-57. Unique Identifier : AIDSLINE MED/99064547; Sherry B; Espinoza M; Manogue KR; Cerami A; Picower Institute for Medical Research, Manhasset, New York, USA.; bsherry@picower.edu; The macrophage occupies a central role in the host response to invasion, exerting its control over the developing inflammatory response largely through the elaboration of an assortment of endogenous mediators including many cytokines. The beta chemokine peptides, macrophage inflammatory protein [MIP]-1 alpha and MIP-1
[Lack of air conditioning and mycotoxin poisoning are basic co-factors in tropical spastic paraparesis]: Rev Neurol. 1998 Apr;26(152):564-7. Unique Identifier : AIDSLINE MED/99012098; Leon FE; Carpintero M; Bayona J; Gaffga N; Ocampo L; del Castillo N; Department of Neurology, University of Alabama at Birmingham,; USA.; INTRODUCTION: Chronic idiopathic spastic paraparesis (CHISPA) have been associated to HTLV-I virus infection, and unknown environmental factors have been suggested to play a role in its pathogenesis. METHOD: Based in our previous studies we wanted to know if the lack of refrigerators and the mycotoxin contamination of
Protease inhibitors, diabetes mellitus and blood lipids.: Diabetes Metab. 1998 Dec;24(6):547-9. Unique Identifier : AIDSLINE MED/99131015; Meyer L; Rabaud C; Ziegler O; May T; Drouin P; Service de Diabetologie, CHU Nancy, France.; We report the case of a patient with human immunodeficiency virus (HIV) and no familial or personal history of metabolic disease, who experienced two diabetes decompensations (severe hyperglycaemia without ketonuria) associated with severe hypertriglyceridaemia, after the introduction of
Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES.: Chem Biol. 1999 Jan;6(1):43-51. Unique Identifier : AIDSLINE MED/99111238; Wilken J; Hoover D; Thompson DA; Barlow PN; McSparron H; Picard L; Wlodawer A; Lubkowski J; Kent SB; Gryphon Sciences, 250 East Grand Avenue, Suite 90, South San; Francisco,CA 94080, USA.; BACKGROUND: RANTES is a CC-type chemokine protein that acts as a chemoattractant for several kinds of leukocytes, playing an important pro-inflammatory role. Entry of human immunodeficiency virus-1 (HIV-1) into cells depends on the chemokine receptor CCR5. RANTES binds CCR5 and inhibits HIV-1 entry into peripheral blo
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.: Cancer Res. 1999 Feb 15;59(4):940-6. Unique Identifier : AIDSLINE MED/99151546; Sun XL; Jayaram HN; Gharehbaghi K; Li QJ; Xiao X; Antony AC; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202, USA.; Cervical carcinoma is an AIDS-defining illness. The expression of folate receptors (FRs) in cervical carcinoma (HeLa-IU1) cells was modulated by stable transduction of FR cDNA encapsidated in recombinant adeno-associated virus-2 in the sense and antisense orientation (sense and antisense cells, respectively). Although
Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma.: Cancer Res. 1999 Feb 15;59(4):975-81. Unique Identifier : AIDSLINE MED/99151551; Nagaoka Y; Kabeya H; Onuma M; Kasai N; Okada K; Aida Y; Tsukuba Life Science Center, The Institute of Physical and; Chemical Research (RIKEN), Ibaraki, Japan.; For the further characterization of bovine leukemia virus (BLV)-induced leukemogenesis, we investigated the association between polymorphism of ovine leukocyte antigen (OLA)-DRB1 gene and tumor development after infection of sheep with BLV. We infected 28 sheep with BLV and cloned exon 2 of the OLA-DRB1 gene from asym
Observations from the CDC. The urgent need for new HIV/STD prevention options for women.: J Womens Health. 1998 Nov;7(9):1081-6. Unique Identifier : AIDSLINE MED/99078576; Irwin K; Scarlett M; Moseley R; Division of STD Prevention, National Center for HIV, STD, and TB; Prevention, Atlanta, Georgia, USA.
Augmentation of therapeutic antitumor immunity by B16F10 melanoma cells transfected by interferon-gamma and allogeneic MHC class I cDNAs.: Mol Cells. 1998 Oct 31;8(5):629-36. Unique Identifier : AIDSLINE MED/99072173; Lim YS; Kang BY; Kim EJ; Kim SH; Hwang SY; Kim TS; College of Pharmacy, Chonnam National University, Kwangju, Korea.; The cDNAs for interferon-gamma (IFN-gamma) and allogeneic H-2Kd molecules were transfected into highly metastatic B16F10 melanoma cells (H-2b), and the synergistic effects of the antitumor immune responses by the doubly transfected cells (B16/Kd/IFN-gamma cells) were investigated in C57BL/6 mice (H-2b). The singly tra
The risk of occupational exposure and infection with infectious diseases: Part 2.: Home Care Provid. 1998 Dec;3(6):304-5. Unique Identifier : AIDSLINE MED/99154476; Sharbaugh RJ; drbob6@aol.com; This article is the second of a series devoted to the epidemiology of selected infectious diseases known to be transmitted in health care settings. In subsequent issues, the relative risk of occupational exposure to and infection with these diseases will be discussed. Part 1 (October 1998 Home Care Provider) consisted
Solution structure of peptides from HIV-1 Vpr protein that cause membrane permeabilization and growth arrest.: J Pept Sci. 1998 Nov;4(7):426-35. Unique Identifier : AIDSLINE MED/99066695; Yao S; Torres AM; Azad AA; Macreadie IG; Norton RS; Biomolecular Research Institute, Parkville, Victoria, Australia.; Vpr, one of the accessory gene products encoded by HIV-1, is a 96-residue protein with a number of functions, including targeting of the viral pre-integration complex to the nucleus and inducing growth arrest of dividing cells. We have characterized by 2D NMR the solution conformations of bioactive synthetic peptide f
Biological and conformational studies on analogues of a synthetic peptide enhancing HIV-1 infection.: J Pept Sci. 1998 Nov;4(7):436-48. Unique Identifier : AIDSLINE MED/99066696; Dettin M; Scarinci C; Zanotto C; Roncon R; De Rossi A; Di Bello C; Department of Chemical Process Engineering, University of Padua,; Italy. peptide@uxl.unipd.it; We have previously demonstrated that a 23-amino acid peptide derived from the V3 loop of the surface glycoprotein of the HIV-1 strain MN is able to bind CD4 and to enhance HIV-1 infection. Further studies have suggested that the peptide/CD4 interaction induces an increase in both CD4 expression and CD4/gp120 binding a
Prospective evaluation of a flow chart using a risk assessment for the diagnosis of STDs in primary healthcare centres in Libreville, Gabon.: Sex Transm Infect. 1998 Jun;74 Suppl 1:S128-32. Unique Identifier : AIDSLINE MED/99147444; Bourgeois A; Henzel D; Dibanga G; Malonga-Mouelet G; Peeters M; Coulaud JP; Fransen L; Delaporte E; Institut de Medecine et d'Epidemiologie Africaines, CHU; Bichat-C Bernard, Paris, France.; BACKGROUND: The serious impact of STDs on women and children in particular, and the linkage between STDs and HIV infection are a profound concern to public health worldwide. One of the main strategies against STDs is based on early diagnosis and treatment. However, this approach is limited by the lack of appropriate l
Evaluation of syndromic patient management algorithm for urethral discharge.: Sex Transm Infect. 1998 Jun;74 Suppl 1:S29-33. Unique Identifier : AIDSLINE MED/99147431; Djajakusumah T; Sudigdoadi S; Keersmaekers K; Meheus A; Department of Dermatovenereology, Universitas Padjadjaran,; Bandung, Indonesia.; OBJECTIVE: To determine feasibility, validity, and cost effectiveness of the syndromic approach to male patients with urethral discharge in Bandung, Indonesia . METHODS: The WHO algorithm on urethral discharge with no microscopy available was evaluated. Patients presented with a
Reproductive tract infections in primary healthcare, family: Unique Identifier : AIDSLINE MED/99147439
Tuberculosis meningitis in Hong Kong: experience in a regional hospital.: Int J Tuberc Lung Dis. 1998 Dec;2(12):1040-3. Unique Identifier : AIDSLINE MED/99084468; Mak W; Cheung RT; Ho SL; Tsang KL; Fong GC; Department of Medicine, Queen Mary Hospital, University of Hong; Kong, PRC.; Tuberculous meningitis (TBM) remains common in Hong Kong . From January 1996 to June 1997, 11 adult patients with TBM presented to Queen Mary Hospital, a regional hospital in Hong Kong. The annual incidence of TBM was estimated at 1.
Management of pulmonary tuberculosis suspects with negative sputum smears and normal or minimally abnormal chest radiographs in resource-poor settings.: Int J Tuberc Lung Dis. 1998 Dec;2(12):999-1004. Unique Identifier : AIDSLINE MED/99084461; Harries AD; Banda HT; Boeree MJ; Welby S; Wirima JJ; Subramanyam VR; Maher D; Nunn P; Department of Medicine, College of Medicine, Blantyre, Malawi.; SETTING: Queen Elizabeth Central Hospital, Blantyre, Malawi . OBJECTIVES: 1) To determine the proportion of pulmonary tuberculosis (PTB) suspects with negative sputum smears and a normal/minimally abnormal chest radiograph (CXR) who are culture-positive for Mycobacterium tuberculosi
Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block copolymer adjuvant in patients with advanced cancer.: Clin Cancer Res. 1997 Dec;3(12 Pt 1):2355-62. Unique Identifier : AIDSLINE MED/99111192; Triozzi PL; Stevens VC; Aldrich W; Powell J; Todd CW; Newman MJ; The Ohio State University Comprehensive Cancer Center, 410 West; 10th Ave, Columbus, Ohio 43210, USA.; The clinical and immunological effects of a vaccine consisting of CTP37, a synthetic peptide corresponding to the COOH-terminal peptide (CTP) of beta-human chorionic gonadotropin (beta-hCG) conjugated to diphtheria toxoid, combined with CRL 1005, a novel synthetic nonionic block copolymer adjuvant, were examined. Twen
AIDS and mental health--Part I.: Harv Ment Health Lett. 1999 Mar;15(9):1-4 cont. Unique Identifier : AIDSLINE MED/99154416
Signals that regulate the host response to Mycobacterium tuberculosis.: Novartis Found Symp. 1998;217:145-57; discussion 157-9. Unique Identifier : AIDSLINE MED/99134965; Beyers AD; van Rie A; Adams J; Fenhalls G; Gie R; Beyers N; MRC Centre for Molecular and Cellular Biology, Faculty of; Medicine, University of Stellenbosch, Tygerberg, South Africa.; An appropriate T helper (Th) 1 immune response is required for the elimination of Mycobacterium tuberculosis. The factors regulating the polarization of mouse or human T cells to produce Th1 or Th2 cytokines are briefly reviewed. These factors include host genetics, cytokines present at the site of T cell activation,
Using conventional and molecular epidemiological analyses to target tuberculosis control interventions in a low incidence area.: Novartis Found Symp. 1998;217:42-54; discussion 54-6. Unique Identifier : AIDSLINE MED/99134959; Hopewell PC; Division of Pulmonary and Critical Care Medicine, San Francisco; General Hospital, CA 94110, USA.; To consolidate the gains made in controlling tuberculosis in industrialized countries in the past five years, we must analyse carefully the epidemiology of the disease and the effectiveness of various control interventions. In San Francisco we have performed conventional and molecular epidemiological analyses that hav
Immunological and endocrinological characteristics of tuberculosis that provide opportunities for immunotherapeutic intervention.: Unique Identifier : AIDSLINE MED/99134961; Rook GA; Hernandez-Pando R; Immunity to tuberculosis requires a T helper 1 (Th1) response which can be compromised by excessive release of inflammatory cytokines or Th2 activity. Environmental saprophytes can protect against tuberculosis by inducing Th1 recognition of the common antigens, or make mice more susceptible to tuberculosis than unimmu
In vitro activity of terbinafine against clinical isolates of dermatophytes.: Med Mycol. 1998 Aug;36(4):235-7. Unique Identifier : AIDSLINE MED/99102707; Arzeni D; Barchiesi F; Compagnucci P; Cellini A; Simonetti O; Offidani AM; Scalise G; Istituto di Malattie Infettive e Medicina Pubblica, Universita; degli Studi di Ancona, Italy.; A broth macrodilution method following the recommendations established by the National Committee for Clinical Laboratory Standards was employed for testing terbinafine against 20 clinical isolates of dermatophytes belonging to seven species. The minimal inhibitory concentrations resulting in either 80% or 100% inhibit
Comments on Microsporum canis [letter]: Med Mycol. 1998 Aug;36(4):247-8. Unique Identifier : AIDSLINE MED/99102710; Mancianti F
Flow injection with chemical reaction interface-isotope ratio mass spectrometry: an alternative to off-line combustion for detecting low levels of enriched 13C in mass balance studies.: J Am Soc Mass Spectrom. 1999 Feb;10(2):153-8. Unique Identifier : AIDSLINE MED/99125230; Chen P; Teffera Y; Black GE; Abramson FP; Department of Pharmacology, George Washington University School; of Medicine and Health Sciences, Washington, DC 20037, USA.; We have evaluated the potential of flow injection chemical reaction interface isotope-ratio mass spectrometry to replace radioactive labeling techniques in material balance studies. A sample is flow injected and transmitted through a desolvation system followed by combustion to form 13CO2 with a microwave-powered chem
Identification of in vitro metabolites of Indinavir by "intelligent automated LC-MS/MS" (INTAMS) utilizing triple quadrupole tandem mass spectrometry.: J Am Soc Mass Spectrom. 1999 Feb;10(2):175-83. Unique Identifier : AIDSLINE MED/99125232; Yu X; Cui D; Davis MR; Department of Drug Metabolism, Merck Research Laboratories, West; Point, Pennsylvania, USA.; In an effort to improve the efficiency of the TSQ 7000 LC-MS/MS system for identification of drug metabolites in biological matrices in support of drug discovery programs, a combination of instrument control language procedures for the Finnigan MAT TSQ 7000 mass spectrometer, referred to as INTAMS, were composed. INTA
The human polyomavirus, JCV, and neurological diseases (review).: Int J Mol Med. 1998 Apr;1(4):647-55. Unique Identifier : AIDSLINE MED/99074470; Gordon J; Khalili K; Center for NeuroVirology and NeuroOncology, Allegheny University; of the Health Sciences, Broad and Vine, MS 406, Philadelphia, PA; 19102, USA.; JC virus, a human neurotropic polyomavirus, is the established etiologic agent of the fatal demyelinating disease, progressive multifocal leukoencephalopathy, which usually affects individuals with defects in cell-mediated immunity. Cytolytic destruction of oligodendrocytes, the myelin-producing cells of the central n
IgG subclass reactivity to human cardiac myosin in cardiomyopathy patients is indicative of a Th1-like autoimmune disease.: Clin Exp Immunol. 1999 Feb;115(2):236-47. Unique Identifier : AIDSLINE MED/99132253; Skyllouriotis P; Skyllouriotis-Lazarou M; Natter S; Steiner R; Spitzauer S; Kapiotis S; Valent P; Hirschl AM; Guber SE; Laufer G; Wollenek G; Wolner E; Wimmer M; Valenta R; General & Experimental Pathology, Vienna General Hospital,; University of Vienna, Medical School, Vienna, Austria.; Studies performed in mice together with the demonstration of increased levels of heart-specific autoantibodies, cytokines and cytokine receptors in sera from cardiomyopathy (CMP) patients argued for a pathogenic role of autoimmune mechanisms in CMP. This study was designed to analyse the presence of IgG anti-heart ant
Mechanisms of Mycobacterium avium-induced resistance against insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice: role of Fas and Th1 cells.: Clin Exp Immunol. 1999 Feb;115(2):248-54. Unique Identifier : AIDSLINE MED/99132254; Martins TC; Aguas AP; Institute for Molecular and Cell Biology, Department of Anatomy; of the Institute Abel Salazar for the Biomedical Sciences,; University of Porto, Portugal.; NOD mice spontaneously develop autoimmune diabetes. One of the manipulations that prevent diabetes in NOD mice is infection with mycobacteria or immunization of mice with mycobacteria-containing adjuvant. Infection of NOD mice with Mycobacterium avium, done before the mice show overt diabetes, results in permanent pro
The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse.: Clin Exp Immunol. 1999 Feb;115(2):260-7. Unique Identifier : AIDSLINE MED/99132256; Ablamunits V; Elias D; Cohen IR; Department of Immunology, the Weizmann Institute of Science,; Rehovot, Israel.; The aim of the present study was to investigate the pathogenic properties of islet-infiltrating lymphocytes related to the severity of the autoimmune destruction of islet beta-cells in the NOD mouse. We analysed the development of insulin-dependent diabetes mellitus (IDDM) produced by adoptive transfer of islet lympho
Apoptosis of Th1-like cells in experimental tuberculosis (TB).: Clin Exp Immunol. 1999 Feb;115(2):324-8. Unique Identifier : AIDSLINE MED/99132265; Das G; Vohra H; Saha B; Agrewala JN; Mishra GC; National Centre for Cell Sciences, Ganeshkhind, Pune 411007,; India.; Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp
Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1.: Clin Exp Immunol. 1999 Feb;115(2):335-41. Unique Identifier : AIDSLINE MED/99132267; Lu Y; Xin KQ; Hamajima K; Tsuji T; Aoki I; Yang J; Sasaki S; Fukushima J; Yoshimura T; Toda S; Okada E; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, Japan.; CD8+ cell-secreted CC-chemokines, MIP-1alpha, and MIP-beta have recently been identified as factors which suppress HIV. In this study we co-inoculated MIP-1alpha expression plasmid with a DNA vaccine constructed from HIV-1 pCMV160IIIB and pcREV, and evaluated the effect of the adjuvant on HIV-specific immune responses
Maintenance hemodialysis in patients with HIV-associated nephropathy.: Unique Identifier : AIDSLINE MED/99092937; Dave MB; Shabih K; Blum S; OBJECTIVE: End-stage renal disease (ESRD) patients infected with human immunodeficiency virus (HIV) have poor survival on maintenance hemodialysis. Only a few studies have evaluated survival time on the basis of demographic and clinical factors. The clinical category of the HIV infection and total CD4 counts are commo
T-cell reactivity and its predictive role in immunosuppression after burns [see comments]: Crit Care Med. 1999 Jan;27(1):66-72. Unique Identifier : AIDSLINE MED/99131594; Zedler S; Bone RC; Baue AE; von Donnersmarck GH; Faist E; Department of Surgery, Klinikum Grosshadern,; Ludwig-Maximilians-University Munich, Germany.; OBJECTIVE: To obtain further insight into the constitutional, phenotype-dependent changes of T-helper-1 and T-helper-2 signature lymphokine synthesis after trauma. DESIGN: Prospective, descriptive study. SETTING: Intensive care unit of a burn center in a community hospital. PATIENTS: Ten patients 1, 3, 5, and 7 days a
A question of balance [editorial; comment]: Crit Care Med. 1999 Jan;27(1):7-8. Unique Identifier : AIDSLINE MED/99131572; Zimmerman JJ
Pericardial involvement in human immunodeficiency virus infection.: Chest. 1999 Feb;115(2):418-22. Unique Identifier : AIDSLINE MED/99149687; Silva-Cardoso J; Moura B; Martins L; Mota-Miranda A; Rocha-Goncalves F; Lecour H; Oporto Cardiovascular Research and Development Unit (JNICT; 51/94), Porto Medical School, Hospital de S. Joao, Portugal.; STUDY OBJECTIVES: Previous studies have showed that the pericardium is frequently involved in HIV infection. However, the characteristics and etiology of the pericardial abnormalities that have been found remained poorly defined. We analyzed the features of pericardial involvement in these patients and investigated th
Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis: molecular analysis of class II alleles by DNA amplification and oligonucleotide hybridization in Mexican patients.: Chest. 1999 Feb;115(2):428-33. Unique Identifier : AIDSLINE MED/99149689; Teran-Escandon D; Teran-Ortiz L; Camarena-Olvera A; Gonzalez-Avila G; Vaca-Marin MA; Granados J; Selman M; Instituto Nacional de Enfermedades Respiratorias, Mexico DF,; Mexico.; BACKGROUND: Pulmonary tuberculosis (PTB) develops by a complex combination of environmental factors with genetic susceptibility. In this context, an association between human leukocyte antigens (HLAs) and tuberculosis has been examined in several populations, but results have been controversial. DESIGN AND MEASUREMENT
Detection of pulmonary tuberculosis in patients with a normal chest radiograph.: Chest. 1999 Feb;115(2):445-52. Unique Identifier : AIDSLINE MED/99149692; Marciniuk DD; McNab BD; Martin WT; Hoeppner VH; Division of Tuberculosis Control, The Research Center for the; Elimination of Tuberculosis, Royal University Hospital,; University of Saskatchewan, Saskatoon, Canada.; OBJECTIVES: To describe the early symptoms of pulmonary tuberculosis (TB) when the chest radiograph (CXR) is normal. SETTING: Centralized, provincial TB control program. SUBJECTS: Twenty-five patients with culture-positive pulmonary TB and a normal CXR were identified from a review of 518 consecutive patients with cul
[Effects of green tea on growth inhibition and immune regulation of Lewis lung cancer in mice]: Chung Hua Yu Fang I Hsueh Tsa Chih. 1997 Nov;31(6):325-9. Unique Identifier : AIDSLINE MED/99080198; Zhu M; Gong Y; Ge G; Institute of Radiation Medicine, Academy of Military Medical; Sciences, Beijing.; C57/BL6J mice were inoculated with Lewis lung cancer cells as an experimental model to study the effects of green tea on cancer prevention, inhibition of tumor growth and immune regulation in mice with tumor. Results showed that weight of thymus in C57/BL6J mice and its index declined, proportion of positive CD4 subgr
Toxicokinetics of 2',3'-didehydro-3'-deoxythymidine, stavudine (D4T).: Drug Metab Dispos. 1999 Jan;27(1):1-12. Unique Identifier : AIDSLINE MED/99102127; Kaul S; Dandekar KA; Schilling BE; Barbhaiya RH; Metabolism and Pharmacokinetics and Drug Safety Evaluation,; Bristol-Myers Squibb Pharmaceutical Research Institute,; Princeton, New Jersey 08543-4000, USA.; The toxicokinetic profile of D4T was assessed by conducting in vivo and in vitro studies. In the various studies, the i.v. and oral doses ranged from 12.5 to 600 and 5 to 2000 mg/kg, respectively. D4T was rapidly absorbed with an absolute oral bioavailability ranging from 77 to 100% in various species. The steady-stat
First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme.: Drug Metab Dispos. 1999 Jan;27(1):113-21. Unique Identifier : AIDSLINE MED/99102143; Wen Y; Remmel RP; Zimmerman CL; Departments of Pharmaceutics and Medicinal Chemistry, University; of Minnesota, College of Pharmacy, Minneapolis, Minnesota 55455,; USA.; Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2 ,3 -didehydro-2 , 3 -dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained fr
Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys.: Drug Metab Dispos. 1999 Jan;27(1):41-5. Unique Identifier : AIDSLINE MED/99102131; Balani SK; Kauffman LR; deLuna FA; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; Efavirenz (EFV, Sustiva , Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Pharmacokinetics of EFV was studied in rats an
In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.: Drug Metab Dispos. 1999 Jan;27(1):86-91. Unique Identifier : AIDSLINE MED/99102138; Kumar GN; Jayanti V; Lee RD; Whittern DN; Uchic J; Thomas S; Johnson P; Grabowski B; Sham H; Betebenner D; Kempf DJ; Denissen JF; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064-3500, USA. gondi.kumar@abbott.com; HIV protease inhibitor ABT-378 (ABT-378) was metabolized very extensively and rapidly by liver microsomes from mouse, rat, dog, monkey, and humans. The rates of NADPH-dependent metabolism of ABT-378 ranged from 2.39 to 9.80 nmol.mg microsomal protein-1.min-1, with monkey liver microsomes exhibiting the highest rates o
[Focal mycobacterial lymphadenitis after starting highly active antiretroviral therapy]: Dtsch Med Wochenschr. 1999 Jan 22;124(3):45-8. Unique Identifier : AIDSLINE MED/99141958; Schwietert M; Battegay M; Medizinische Universitats-Poliklinik, Kantonsspital Basel.; HISTORY AND FINDINGS: A 30-year-old man with a known HIV infection for 7 years presented for treatment with antiretroviral drugs. He was known to have had herpes zoster, oral hairy leukoplakia and recurrent Candida stomatitis, but was otherwise without symptoms. INVESTIGATIONS: The CD4 lymphocyte count was 19 cells/mm
Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides.: Electrophoresis. 1998 Nov;19(16-17):2926-9. Unique Identifier : AIDSLINE MED/99085937; Vargas G; Revilla A; Havel J; Holy A; Masaryk University, Faculty of Science, Department of Analytical; Chemistry, Brno, Czech Republic.; The present work describes an electrophoretic method for the separation and determination of the new antivirals, 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,9-diaminopurine (PMEDAP) in model mixtures with some monoribonucleotide isomers (3 -AMP, 2 -CMP, 3 -CMP, 3 -GMP, 2 -GMP, 3 -UMP,
HPV and intraepithelial neoplasia recurrent lesions of the lower genital tract: assessment of the immune system.: Eur J Gynaecol Oncol. 1998;19(5):466-9. Unique Identifier : AIDSLINE MED/99079618; Stentella P; Frega A; Ciccarone M; Cipriano L; Tinari A; Tzantzoglou S; Pachi A; II Clinic of Obstetrics and Gynecology, University of Rome La; Sapienza, Italy.; OBJECTIVE: To evaluate the immune state in patients with genital relapse HPV and intraepithelial lesions of the lower genital tract. METHOD: Forty-three patients were selected. Twenty-one were affected by recurrent HPV infection either alone or combined with intraepithelial neoplasia treated by laser surgery, and 22 h
Risk of human immunodeficiency virus infection and genital ulcer disease among persons attending a sexually transmitted disease clinic in Italy.: Epidemiol Infect. 1998 Dec;121(3):623-30. Unique Identifier : AIDSLINE MED/99153783; Corona R; Caprilli F; Tosti ME; Gentili G; Giglio A; Prignano G; Pasquini P; Mele A; Laboratorio di Epidemiologia Clinica, Istituto Dermopatico; dell'Immacolata (IDI-IRCCS), Rome, Italy.; To assess the relative importance of ulcerative and non-ulcerative sexually transmitted disease in the transmission of HIV, a seroprevalence study was conducted on 2210 patients at the sexually transmitted diseases (STD) clinic of the S. Maria e S. Gallicano Hospital in Rome, between 1989 and 1994. Among male patients
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.: FEBS Lett. 1999 Jan 25;443(2):170-4. Unique Identifier : AIDSLINE MED/99142705; Wang L; Munch-Petersen B; Herrstrom Sjoberg A; Hellman U; Bergman T; Jornvall H; Eriksson S; Department of Veterinary Medical Chemistry, Swedish University of; Agricultural Sciences, Biomedical Center, Uppsala.; Based on amino acid sequence information from purified mitochondrial thymidine kinase (TK2), a cDNA of 1930 bp was cloned, containing an open reading frame encoding 232 amino acid residues starting with the N-terminal sequence determined from the native human protein preparation. Northern blot analysis with the cDNA c
HIV-1 gp160 decreases the K+ voltage-gated current from Jurkat E6.1 T cells by up-phosphorylation.: FEBS Lett. 1999 Jan 25;443(2):187-91. Unique Identifier : AIDSLINE MED/99142708; Dellis O; Bouteau F; Guenounou M; Rona JP; Laboratoire d'Electrophysiologie des Membranes, LPCMSP,; Universite Denis Diderot, Paris 7, France.; odellis@moka.ccr.jussieu.fr; HIV-1 gp120/gp160 is known to disturb the activity of p56lck, protein kinase C (PKC) and Ca2+ homeostasis in T lymphocytes. We found that gp160 decreases the Kv1.3 current of Jurkat E6.1 cells probably by increasing the PKC-dependent phosphorylation of Kv channel protein after 5 days. This decrease is dose-dependent.
Posttraumatic stress disorder in response to HIV infection.: Gen Hosp Psychiatry. 1998 Nov;20(6):345-52. Unique Identifier : AIDSLINE MED/99071810; Kelly B; Raphael B; Judd F; Perdices M; Kernutt G; Burnett P; Dunne M; Burrows G; Department of Psychiatry, University of Queensland, Brisbane,; Australia.; This study investigated the psychological impact of HIV infection through assessment of posttraumatic stress disorder in response to HIV infection. Sixty-one HIV-positive homosexual/bisexual men were assessed for posttraumatic stress disorder in response to HIV infection (PTSD-HIV) using a modified PTSD module of the
Treatment with risperidone of an acute psychotic episode in a patient with AIDS [letter]: Gen Hosp Psychiatry. 1998 Nov;20(6):384-5. Unique Identifier : AIDSLINE MED/99071818; Zilikis N; Nimatoudis I; Kiosses V; Ierodiakonou C
AIDS drug gets quick OK [news]: FDA Consum. 1999 Jan-Feb;33(1):2. Unique Identifier : AIDSLINE MED/99154407
[How to increase immune response in HIV-infected patients]: Fortschr Med. 1998 Nov 30;116(33):6. Unique Identifier : AIDSLINE MED/99106133; Gurtler L
Analysis of clonality of atypical cutaneous lymphoid infiltrates associated with drug therapy by PCR/DGGE.: Hum Pathol. 1999 Feb;30(2):130-6. Unique Identifier : AIDSLINE MED/99151897; Brady SP; Magro CM; Diaz-Cano SJ; Wolfe HJ; Department of Pathology, Tufts University School of Medicine,; Boston, MA, USA.; Atypical lymphocytic infiltrates that mimic cutaneous lymphoma (ie, pseudolymphoma) are often observed in skin biopsy specimens from patients with altered immune function. The latter may reflect systemic immune dysregulatory states such as collagen vascular disease or human immunodeficiency virus infection. Among the
Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes.: Immunol Lett. 1998 Nov;64(1):45-7. Unique Identifier : AIDSLINE MED/99081199; Pardridge WM; Yang J; Diagne A; Department of Medicine, UCLA School of Medicine, Los Angeles, CA; 90095-1682, USA. wpardrid@med1.medsch.ucla.edu; Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human
Elevation of serum IgE level and peripheral eosinophil count during T lymphocyte-directed gene therapy for ADA deficiency: implication of Tc2-like cells after gene transduction procedure.: Immunol Lett. 1998 Nov;64(1):49-53. Unique Identifier : AIDSLINE MED/99081200; Kawamura N; Ariga T; Ohtsu M; Yamada M; Tame A; Furuta H; Kobayashi I; Okano M; Yanagihara Y; Sakiyama Y; Department of Pediatrics, Hokkaido University School of Medicine,; Sapporo, Japan. nobu-ka@med.hokudai.ac.jp; We have successfully carried out T-cell-directed gene therapy for a boy with severe combined immunodeficiency due to adenosine deaminase deficiency (ADA SCID) and unexpectedly found an elevation of serum IgE level and peripheral eosinophil count during the course. More than 90% of transduced cells cultured for 7-11 da
Cytokine patterns in seropositive and seronegative patients with Echinococcus granulosus infection.: Immunol Lett. 1998 Nov;64(1):5-8. Unique Identifier : AIDSLINE MED/99081193; Rigano R; Profumo E; Ioppolo S; Notargiacomo S; Teggi A; Siracusano A; Laboratorio di Immunologia, Istituto Superiore di Sanita, Roma,; Italy.; To investigate the involvement of immunological variables, including the Th1/Th2 balance, in the mechanisms underlying seronegativity in cystic echinococcosis (CE), Th1 and Th2 cytokines were evaluated in ELISA determining IFN-gamma, IL-4, -5 and -10 production in peripheral blood mononuclear cell (PBMC) cultures from
Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci.: Immunogenetics. 1999 Mar;49(3):238-41. Unique Identifier : AIDSLINE MED/99115509; Scalzo AA; Brown MG; Chu DT; Heusel JW; Yokoyama WM; Forbes CA; Department of Microbiology, University of Western Australia,; Nedlands 6907, Western Australia, scals@cyllene.uwa.edu.au
New, emerging and re-emerging infectious diseases [editorial]: Indian J Public Health. 1997 Apr-Jun;41(2):35. Unique Identifier : AIDSLINE MED/99143519; Bansal RD; Bhasin SK
Relationship of national highway with injecting drug abuse and HIV in rural Manipur, India.: Indian J Public Health. 1997 Apr-Jun;41(2):49-51. Unique Identifier : AIDSLINE MED/99143522; Sarkar K; Panda S; Das N; Sarkar S; ICMR Unit for Research on AIDS in North-Eastern States of India,; Calcutta.; Earlier study reported that about 1% of general population or urban Manipur was injecting drug users (IDUs). A study was conducted to observe the IDU prevalence in rural Manipur and the role of national highway (NH) in determining the IDU prevalence if any. It was also aimed to study the HIV prevalence among IDUs of d
Koro associated with phobia for AIDS.: Int J Psychiatry Med. 1998;28(3):353-6. Unique Identifier : AIDSLINE MED/99060829; Chand SP; Sultan Qaboos University, Muscat, Sultanate of Oman.; Koro, in its complete, classic form has been described as a culture bound syndrome. It usually occurs in otherwise healthy individuals in the context of acute, severe anxiety. The incomplete form of Koro is said to occur as part of a recognizable primary psychiatric disorder. A case report is presented for the first t
Sexuality in the age of AIDS [letter]: Int J Psychoanal. 1998 Oct;79 ( Pt 5):1007-8. Unique Identifier : AIDSLINE MED/99089006; Blechner MJ
HIV knowledge, beliefs and sexual behavior of male heterosexual drug users and non-drug users attending an HIV testing clinic in Israel.: Isr J Psychiatry Relat Sci. 1998;35(4):307-17. Unique Identifier : AIDSLINE MED/99143534; Soskolne V; Maayan S; Department of Social Medicine, Hadassah University Hospital,; Jerusalem, Israel. varda@vms.huji.ac.il; The aim of the study was to compare HIV-related knowledge, beliefs in self-control and sexual behavior of non-drug using and drug using heterosexual men. All individuals attending an HIV testing site during a two-month period were asked to complete a questionnaire anonymously. Data for 49 drug users (DU), most of them
A world of research subjects.: Hastings Cent Rep. 1998 Nov-Dec;28(6):25. Unique Identifier : AIDSLINE MED/99085498; Emanuel EJ
AZT trials and tribulations.: Hastings Cent Rep. 1998 Nov-Dec;28(6):26-34. Unique Identifier : AIDSLINE MED/99085499; Crouch RA; Arras JD
Science in the service of healing.: Hastings Cent Rep. 1998 Nov-Dec;28(6):34-8. Unique Identifier : AIDSLINE MED/99085500; Grady C
Placebos and HIV. Lessons learned.: Hastings Cent Rep. 1998 Nov-Dec;28(6):43-8. Unique Identifier : AIDSLINE MED/99085502; Levine C
Gradual loss of IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS.: Hawaii Med J. 1998 Dec;57(12):733-4. Unique Identifier : AIDSLINE MED/99109265; Nerurkar VR; Chua PK; Shikuma CM; Dashwood WM; Milne CI; Woodward CL; Kobayashi G; Peterson JE; Yanagihara R; Retrovirology Research Laboratory, University of Hawaii at Manoa,; Honolulu, USA.; GB virus C/hepatitis G virus (GBV-C/HGV) is a positive-sense, single-stranded RNA virus belonging to the family Flaviviridae and is distantly related to hepatitis C virus (HCV). GBV-C/HGV can be transmitted by the parenteral and the sexual route. Among individuals infected with human immunodeficiency virus type 1 (HIV
The complexities of HIV testing mount [news]: J Ark Med Soc. 1999 Jan;95(8):334. Unique Identifier : AIDSLINE MED/99125604; Zuger A
CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.: J Biol Chem. 1999 Jan 29;274(5):3116-24. Unique Identifier : AIDSLINE MED/99115659; Slavik JM; Hutchcroft JE; Bierer BE; Department of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1 or Th2 differentiation. We have examined early signal transduction pathways recruited following T cell stimulation with either CD80 or CD86. Purified human peripheral T cells or Jurkat T cel
Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells.: J Biol Chem. 1999 Feb 5;274(6):3789-96. Unique Identifier : AIDSLINE GENBANK/AJ005355; Monnet C; Laune D; Laroche-Traineau J; Biard-Piechaczyk M; Briant L; Bes C; Pugniere M; Mani JC; Pau B; Cerutti M; Devauchelle G; Devaux C; Granier C; Chardes T; Faculte de Pharmacie, 15 Avenue Charles Flahault, 34060; Montpellier, France.; The monoclonal antibody (mAb) ST40, specific for the immunoglobulin complementarity-determining region (CDR) 3-like loop in domain 1 of the CD4 molecule, inhibits human immunodeficiency virus type 1 (HIV-1) promoter activity and viral transcription in HIV-infected cells. To design synthetic peptides from the ST40 para
3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection.: Unique Identifier : AIDSLINE MED/99121132; Kosa JL; Sweasy JB; We developed an in vivo selection to identify
The 1998 Lindberg Award. Comparison of glycerol preservation with cryopreservation methods on HIV-1 inactivation.: J Burn Care Rehabil. 1998 Nov-Dec;19(6):494-500. Unique Identifier : AIDSLINE MED/99064505; van Baare J; Cameron PU; Vardaxis N; Pagnon J; Reece J; Middelkoop E; Crowe SM; Euro Skin Bank, Beverwijk, The Netherlands. vanbaare@wxs.nl; Cryopreservation and glycerol preservation are 2 successful methods for long-term preservation of human cadaver skin. Preservation is subjected to strict criteria to minimize the risk of disease transmission. This investigation compares the effects of glycerol preservation and cryopreservation on the inactivation of H
Perforating folliculitis: report of a case in an HIV-infected man.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):300-2. Unique Identifier : AIDSLINE MED/99148720; Rubio FA; Herranz P; Robayna G; Pena JM; Contreras F; Casado M; Department of Dermatology, La Paz University Hospital, Madrid,; Spain.
Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):308-11. Unique Identifier : AIDSLINE MED/99148722; Sachsenberg-Studer EM; Dobrynski N; Sheldon J; Schulz TF; Pechere M; Nador RG; Spiliopoulos A; Nicod L; Saurat JH; Department of Dermatology, University Hospital, Geneva,; Switzerland.; Kaposi s sarcoma (KS) has been reported after solid organ transplantation mostly in recipients of renal, liver, heart, and bone allografts. We describe the first case of a patient with lung transplantation who developed KS of the skin, but also of the lung graft. The tumors were localized to places of previous trauma,
Severe paronychia due to zidovudine-induced neutropenia in a neonate.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):322-4. Unique Identifier : AIDSLINE MED/99148726; Russo F; Collantes C; Guerrero J; Department of Dermatology, Hospital Punta de Europa, Algeciras,; Spain. frussod@meditex.es; We describe the case of an HIV-perinatally exposed child who was treated with zidovudine prophylaxis for reduction of perinatal transmission. At 4 weeks of age, he developed severe paronychia of the great toes as a result of Candida albicans and Escherichia coli. At that time, laboratory tests showed anemia and neutro
Disseminated sporotrichosis with extensive cutaneous involvement in a patient with AIDS.: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):350-5. Unique Identifier : AIDSLINE MED/99148734; Ware AJ; Cockerell CJ; Skiest DJ; Kussman HM; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas, USA.; Sporotrichosis most commonly presents as a localized, lymphocutaneous infection that follows trauma, such as an injury from a rose thorn. In patients infected with HIV, it may be widespread and disseminated. We describe a patient with AIDS who developed disseminated sporotrichosis, a rare opportunistic fungal infectio
Knowledge, attitudes and behaviours related to HIV and AIDS among chinese adolescents in hong kong.: J Adolesc. 1998 Dec;21(6):657-65. Unique Identifier : AIDSLINE MED/99138784; Davis C; Noel MB; Chan SF; Wing LS; University of New South Wales, Sydney, NSW 2052, Australia.; The purpose of this study was to assess HIV and AIDS knowledge and attitudes, source of HIV and AIDS information, and behaviours related to HIV and AIDS among Chinese adolescents in Hong Kong . Participants included 1259 (826 females
Asymptomatic HIV under the ADA: the invisible, yet legitimate disability.: J Contemp Health Law Policy. 1998 Fall;15(1):357-400. Unique Identifier : AIDSLINE MED/99143547; Davis CS
Development and standardization of methods to evaluate the antibody response to an HIV-1 candidate vaccine in secretions and sera of seronegative vaccine recipients.: J Immunol Methods. 1999 Jan 1;222(1-2):111-24. Unique Identifier : AIDSLINE MED/99144976; Raux M; Finkielsztejn L; Salmon-Ceron D; Bouchez H; Excler JL; Dulioust E; Grouin JM; Sicard D; Blondeau C; Pasteur Merieux Connaught, Clinical Sero-Immunology Laboratory,; Parc Industriel d'Incarville, Val de Reuil, France.; mraux@fr.pmc-vacc.com; Enzyme-linked immunosorbent assays (ELISA) were developed to test, in serum and mucosal samples, total IgG, total IgA, serum albumin, and anti-gp120 MN and anti-p24 LAI IgG and IgA levels. These ELISAs were optimized according to reagents and experimental conditions. Inter- and intra-assay coefficients of variation ra
CD4+ T cell enumeration in HIV infection with limited resources.: Unique Identifier : AIDSLINE MED/99144985; Sherman GG; Galpin JS; Patel JM; Mendelow BV; Glencross DK; The incidence of human immunodeficiency virus (HIV) infection continues to increase in South Africa . Limited resources are available for diagnosis and management of the disease and the
A mathematical analysis of the spread of HIV/AIDS in Japan.: IMA J Math Appl Med Biol. 1998 Dec;15(4):299-311. Unique Identifier : AIDSLINE MED/99136888; Kakehashi M; Institute of Health Sciences, Hiroshima University School of; Medicine, Japan.; The spread of HIV/AIDS in Japan was analysed using a mathematical model incorporating pair formations between adults and sexual contacts with commercial sex workers. The parameters involved in the model were carefully specified as realistically as possible to the actual situation in
[Advances in the treatment of severe refractory infections. 1) HIV infections]: Nippon Naika Gakkai Zasshi. 1998 Nov 10;87(11):2240-4. Unique Identifier : AIDSLINE MED/99119776; Oka S
Long term treatment with clarithromycin for cryptosporidiosis and emergence of drug resistant disseminated infection due to Mycobacterium avium: case report.: J Chemother. 1998 Dec;10(6):474-5. Unique Identifier : AIDSLINE MED/99091284; Matteelli A; Signorini L; Tebaldi A; Bombana E; Chatel G; Pinsi G; Clinic of Infectious and Tropical Diseases-University of Brescia,; Italy. carosi@master.cci.unibs.it; Macrolide resistance in disseminated Mycobacterium avium infection is of major concern in AIDS patients as these drugs represent the main component of combination therapy . Clarithromycin and azithromycin should not be used alone for the treatment and prophylaxis of the
Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression.: J Pathol. 1998 Oct;186(2):209-14. Unique Identifier : AIDSLINE MED/99123513; Hall AP; Irvine J; Blyth K; Cameron ER; Onions DE; Campbell ME; Department of Veterinary Pathology, Glasgow University Veterinary; School, U.K.; In order to investigate the role that the human T-lymphotropic virus type I (HTLV-I) tax oncogene plays in apoptosis and transformation in vivo, four lines of HTLV-I tax transgenic mice were generated under the regulatory control of the CD3-epsilon promoter-enhancer sequence. These mice develop a variety of phenotypes
New bicyclam-AZT conjugates: design, synthesis, anti-HIV evaluation, and their interaction with CXCR-4 coreceptor.: J Med Chem. 1999 Jan 28;42(2):229-41. Unique Identifier : AIDSLINE MED/99126512; Dessolin J; Galea P; Vlieghe P; Chermann JC; Kraus JL; Laboratoire de Chimie Biomoleculaire, Faculte des Sciences de; Luminy, case 901, Universite de la Mediterranee, 163 avenue de; Luminy, 13288 Marseille Cedex 9, France.; We report the synthesis of mono- and bis-tetraazamacrocycle- AZT conjugates. All new compounds were screened for their ability to inhibit HIV-1 replication in MT4 cell line and were compared to AZT alone. It appears that N-protected covalent prodrugs a
Three-dimensional quantitative structure-activity relationship study on cyclic urea derivatives as HIV-1 protease inhibitors: application of comparative molecular field analysis.: J Med Chem. 1999 Jan 28;42(2):249-59. Unique Identifier : AIDSLINE MED/99126514; Debnath AK; Biochemical Virology Laboratory, Lindsley F. Kimball Research; Institute of The New York Blood Center, 310 East 67th Street, New; York, New York 10021, USA. adebnath@server.nybc.org; Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been developed using comparative molecular field analysis (CoMFA) on a large data set (118 compounds) of diverse cyclic urea derivatives as protease inhibitors against the human imm
Psychosocial factors and high-risk sexual behavior: race differences among urban adolescents.: J Behav Med. 1998 Oct;21(5):451-67. Unique Identifier : AIDSLINE MED/99052851; Doljanac RF; Zimmerman MA; Department of Health Behavior and Health Education, School of; Public Health, University of Michigan, Ann Arbor 48109-2029, USA.; Adolescence is a period of sexual experimentation. We examined psychosocial predictors of high-risk sexual behavior and condom use. The sample included 824 ninth-graders, most of whom are African American. We conducted separate analyses for whites and African Americans. Predictors included alcohol and substance use, d
Cross-linking localization of a HIV-1 reverse transcriptase peptide involved in the binding of primer tRNALys3.: J Mol Biol. 1999 Jan 29;285(4):1339-46. Unique Identifier : AIDSLINE MED/99141382; Dufour E; Reinbolt J; Castroviejo M; Ehresmann B; Litvak S; Tarrago-Litvak L; Andreola ML; IFR 66 Pathologies Infectieuses, CNRS-Universite Victor Segalen; Bordeaux 2, EP-630, 1, rue Camille Saint Saens, Bordeaux Cedex,; 33077, France.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) initiates the synthesis of DNA from the 3 end of its specific primer, tRNALys3. The regions of tRNALys3 in close contact with RT are well known, while a precise knowledge of the RT regions interacting with tRNALys3 is not yet available. To address
Old and new issues in cervical cancer control [editorial; comment]: J Natl Cancer Inst. 1999 Feb 3;91(3):200-1. Unique Identifier : AIDSLINE MED/99154697; Critchlow CW; Kiviat NB
Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women [see comments]: J Natl Cancer Inst. 1999 Feb 3;91(3):226-36. Unique Identifier : AIDSLINE MED/99154704; Palefsky JM; Minkoff H; Kalish LA; Levine A; Sacks HS; Garcia P; Young M; Melnick S; Miotti P; Burk R; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA. joelp@labmed.ucsf.edu; BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women s I
Foamy viruses are unconventional retroviruses.: J Virol. 1999 Mar;73(3):1747-55. Unique Identifier : AIDSLINE MED/99138951; Linial ML; Division of Basic Sciences, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.
The hypervariable domain of the murine leukemia virus surface protein tolerates large insertions and deletions, enabling development of a retroviral particle display system.: J Virol. 1999 Mar;73(3):1802-8. Unique Identifier : AIDSLINE MED/99138957; Kayman SC; Park H; Saxon M; Pinter A; Laboratory of Retroviral Biology, Public Health Research; Institute, New York, New York 10016, USA. skayman@phr.nyu.edu; The surface proteins (SU) of murine type-C retroviruses have a central hypervariable domain devoid of cysteine and rich in proline. This 41-amino-acid region of Friend ecotropic murine leukemia virus SU was shown to be highly tolerant of insertions and deletions. Viruses in which either the N-terminal 30 amino acids o
Genetic analysis of a unique human immunodeficiency virus type 1 (HIV-1) with a primer binding site complementary to tRNAMet supports a role for U5-PBS stem-loop RNA structures in initiation of HIV-1 reverse transcription.: J Virol. 1999 Mar;73(3):1818-27. Unique Identifier : AIDSLINE MED/99138959; Kang SM; Morrow CD; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; Human immunodeficiency virus type 1 (HIV-1) exclusively uses tRNA3Lys to initiate reverse transcription. A novel HIV-1 mutant which stably utilizes tRNAMet rather than tRNA3Lys as a primer was previously identified [HXB2(Met-AC] (S.-M. Kang, Z. Zhang, and C. D. Morrow, J. Virol. 71:207-217, 1997). Comparison of RNA se
Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors.: Unique Identifier : AIDSLINE MED/99138960; Gasmi M; Glynn J; Jin MJ; Jolly DJ; Yee JK; Chen ST; Center for Gene Therapy, Chiron Technologies, San Diego,; California 92121, USA.; A number of human immunodeficiency type 1 (HIV-1)-based vectors have recently been shown to transduce nondividing cells in vivo as well as in vitro. However, if these vectors are to be considered for eventual clinical use, a major consideration is to reduce the probability of unintended generation of replication-compe
Acute effects of pathogenic simian-human immunodeficiency virus challenge on vaccine-induced cellular and humoral immune responses to Gag in rhesus macaques.: J Virol. 1999 Mar;73(3):1853-9. Unique Identifier : AIDSLINE MED/99138963; Steger KK; Waterman PM; Pauza CD; Department of Pathology and Laboratory Medicine, University of; Wisconsin-Madison, and Wisconsin Regional Primate Research; Center, Madison, Wisconsin 53706, USA.; Simian-human immunodeficiency virus (SHIV) infection in macaques provides a convenient model for testing vaccine efficacy and for understanding viral pathogenesis in AIDS. We immunized macaques with recombinant, Salmonella typhimurium (expressing Gag) or soluble Gag in adjuvant to generate T-cell-dependent lymphoproli
Multiple functions for the basic amino acids of the human T-cell leukemia virus type 1 matrix protein in viral transmission.: J Virol. 1999 Mar;73(3):1860-7. Unique Identifier : AIDSLINE MED/99138964; Le Blanc I; Rosenberg AR; Dokhelar MC; INSERM U332, Institut Cochin de Genetique Moleculaire, Paris,; France.; We studied the involvement of the human T-cell leukemia virus type 1 (HTLV-1) Gag matrix protein in the cell-to-cell transmission of the virus using missense mutations of the basic amino acids. These basic amino acids are clustered at the N terminus of the protein in other retroviruses and are responsible for targetin
Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.: J Virol. 1999 Mar;73(3):1868-77. Unique Identifier : AIDSLINE MED/99138965; Koseki S; Tanabe T; Tani K; Asano S; Shioda T; Nagai Y; Shimada T; Ohkawa J; Taira K; National Institute for Advanced Interdisciplinary Research, AIST,; MITI, Tsukuba Science City 305-8562, Institute of Medical; Science, University of Tokyo, Minato-ku, Tokyo 108-8539, Japan.; In order to determine the parameters that govern the activity of a ribozyme in vivo, we made a systematic analysis of chimeric tRNAVal ribozymes by measuring their cleavage activities in vitro as well as the steady-state levels of transcripts, the half-lives of transcribed tRNAVal ribozymes, and their activities in bo
Human immunodeficiency virus type 1 protease triggers a myristoyl switch that modulates membrane binding of Pr55(gag) and p17MA.: J Virol. 1999 Mar;73(3):1902-8. Unique Identifier : AIDSLINE MED/99138969; Hermida-Matsumoto L; Resh MD; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA.; The human immunodeficiency virus type 1 (HIV-1) Pr55(gag) gene product directs the assembly of virions at the inner surface of the cell plasma membrane. The specificity of plasma membrane binding by Pr55(gag) is conferred by a combination of an N-terminal myristoyl moiety and a basic residue-rich domain. Although the
Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.: J Virol. 1999 Mar;73(3):1909-17. Unique Identifier : AIDSLINE MED/99138970; Lin SF; Robinson DR; Miller G; Kung HJ; Department of Molecular Biology and Microbiology, School of; Medicine, Case Western Reserve University, Cleveland, Ohio 44016,; USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is a recently discovered human gamma herpesvirus strongly implicated in AIDS-related neoplasms. We report here the identification in the KSHV genome of a gene for a protein designated K-bZIP and belonging to the basic-leucine zipper (bZIP) family of transcription factors.
Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein.: J Virol. 1999 Mar;73(3):1931-40. Unique Identifier : AIDSLINE MED/99138972; Wilk T; Gowen B; Fuller SD; Structural Biology Programme, European Molecular Biology; Laboratory, 69117 Heidelberg, Germany.; Recently, it was shown that actin molecules are present in human immunodeficiency virus type 1 (HIV-1) particles. We have examined the basis for incorporation and the location of actin molecules within HIV-1 and murine retrovirus particles. Our results show that the retroviral Gag polyprotein is sufficient for actin u
Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.: J Virol. 1999 Mar;73(3):1956-63. Unique Identifier : AIDSLINE MED/99138975; Bartz SR; Emerman M; Divisions of Molecular Medicine and Basic Science, Fred; Hutchinson Cancer Research Center, Seattle, Washington, USA.; Apoptosis contributes to the loss of CD4 cells during human immunodeficiency virus type 1 (HIV-1) infection. Although the product of the env gene, gp160/gp120, is known to play a role in cell death mediated by HIV-1, the role of other HIV-1 genes in the process is unclear. We found that HIV-1 lacking the env gene (HIV
Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.: J Virol. 1999 Mar;73(3):1964-73. Unique Identifier : AIDSLINE MED/99138976; Mangasarian A; Piguet V; Wang JK; Chen YL; Trono D; Department of Genetics and Microbiology, University of Geneva,; Geneva, Switzerland.; The Nef protein of primate lentiviruses triggers the accelerated endocytosis of CD4 and of class I major histocompatibility complex (MHC-I), thereby down-modulating the cell surface expression of these receptors. Nef acts as a connector between the CD4 cytoplasmic tail and intracellular sorting pathways both in the Go
Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteins.: J Virol. 1999 Mar;73(3):1974-9. Unique Identifier : AIDSLINE MED/99138977; Gigler A; Dorsch S; Hemauer A; Williams C; Kim S; Young NS; Zolla-Pazner S; Wolf H; Gorny MK; Modrow S; Institut fur Medizinische Mikrobiologie und Hygiene,; Universitat Regensburg, 93053 Regensburg, Germany.; Infections caused by human parvovirus B19 are known to be controlled mainly by neutralizing antibodies. To analyze the immune reaction against parvovirus B19 proteins, four cell lines secreting human immunoglobulin G monoclonal antibodies (MAbs) were generated from two healthy donors and one human immunodeficiency vir
Conditions for copackaging rous sarcoma virus and murine leukemia virus Gag proteins during retroviral budding.: J Virol. 1999 Mar;73(3):2045-51. Unique Identifier : AIDSLINE MED/99138985; Bennett RP; Wills JW; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.; Rous sarcoma virus (RSV) and murine leukemia virus (MLV) are examples of distantly related retroviruses that normally do not encounter one another in nature. Their Gag proteins direct particle assembly at the plasma membrane but possess very little sequence similarity. As expected, coexpression of these two Gag protei
High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.: J Virol. 1999 Mar;73(3):2064-73. Unique Identifier : AIDSLINE MED/99138988; Chene L; Nugeyre MT; Barre-Sinoussi F; Israel N; Unite de Biologie des Retrovirus, Institut Pasteur, 75724 Paris; Cedex 15, France.; We have previously demonstrated that interaction of infected thymocytes with autologous thymic epithelial cells (TEC) is a prerequisite for a high level of human immunodeficiency virus type 1 (HIV-1) replication in thymocytes (M. Rothe, L. Chene, M. Nugeyre, F. Barre-Sinoussi, and N. I
The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo.: J Virol. 1999 Mar;73(3):2099-108. Unique Identifier : AIDSLINE MED/99138992; Weekes MP; Wills MR; Mynard K; Carmichael AJ; Sissons JG; Department of Medicine, University of Cambridge Clinical School,; Cambridge CB2 2QQ, United Kingdom.; Human cytomegalovirus (HCMV)-specific CD8(+) cytotoxic T lymphocytes (CTL) appear to play an important role in the control of virus replication and in protection against HCMV-related disease. We have previously reported high frequencies of memory CTL precursors (CTLp) specific to t
Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.: J Virol. 1999 Mar;73(3):2126-35. Unique Identifier : AIDSLINE MED/99138995; Wu X; Liu H; Xiao H; Conway JA; Hehl E; Kalpana GV; Prasad V; Kappes JC; Department of Medicine, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN) is essential for integration of the viral DNA into host cell chromosomes. Since IN is expressed and assembled into virions as part of the 160-kDa Gag-Pol precursor polyprotein and catalyzes integration of the provirus in infected cells as a mature
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression.: J Virol. 1999 Mar;73(3):2232-42. Unique Identifier : AIDSLINE MED/99139006; Sun R; Lin SF; Staskus K; Gradoville L; Grogan E; Haase A; Miller G; Department of Molecular Biophysics and Biochemistry, Yale; University School of Medicine, New Haven, Connecticut 06520, USA.; Herpesvirus gene expression can be classified into four distinct kinetic stages: latent, immediate early, early, and late. Here we characterize the kinetic class of a group of 16 Kaposi s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 genes in a cultured primary effusion cell line and examine the expression
In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain.: J Virol. 1999 Mar;73(3):2270-9. Unique Identifier : AIDSLINE MED/99139010; Campbell S; Rein A; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702, USA.; campbells@mail.ncifcrf.gov; Human immunodeficiency virus type 1 (HIV-1) normally assembles into particles of 100 to 120 nm in diameter by budding through the plasma membrane of the cell. The Gag polyprotein is the only viral protein that is required for the formation of these particles. We have used an in vitro assembly system to examine the ass
Dissecting the immune response to moloney murine sarcoma/leukemia virus-induced tumors by means of a DNA vaccination approach.: J Virol. 1999 Mar;73(3):2280-7. Unique Identifier : AIDSLINE MED/99139011; Milan G; Zambon A; Cavinato M; Zanovello P; Rosato A; Collavo D; Immunology Section, Department of Oncology and Surgical Sciences,; University of Padova, 35128 Padua, Italy.; The intramuscular inoculation of Moloney murine sarcoma/leukemia (M-MSV/M-MuLV) retroviral complex gives rise to sarcomas that undergo spontaneous regression due to the induction of a strong immune reaction mediated primarily by cytotoxic T lymphocytes (CTL). We used a DNA-based vaccination approach to dissect the CTL
Identification of retroviral late domains as determinants of particle size.: J Virol. 1999 Mar;73(3):2309-20. Unique Identifier : AIDSLINE MED/99139014; Garnier L; Parent LJ; Rovinski B; Cao SX; Wills JW; Departments of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.; Retroviral Gag proteins, in the absence of any other viral products, induce budding and release of spherical, virus-like particles from the plasma membrane. Gag-produced particles, like those of authentic retrovirions, are not uniform in diameter but nevertheless fall within a fairly narrow distribution of sizes. For
Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage.: J Virol. 1999 Mar;73(3):2343-9. Unique Identifier : AIDSLINE MED/99139017; Morner A; Bjorndal A; Albert J; Kewalramani VN; Littman DR; Inoue R; Thorstensson R; Fenyo EM; Bjorling E; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Swedish Institute for Infectious Disease Control, Stockholm,; Sweden. andreas.morner@mtc.ki.se; Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Since CXCR4 usage determines the biological phenotype for HIV-1 isolates an
V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.: J Virol. 1999 Mar;73(3):2350-8. Unique Identifier : AIDSLINE MED/99139018; Chan SY; Speck RF; Power C; Gaffen SL; Chesebro B; Goldsmith MA; Gladstone Institute of Virology and Immunology, San Francisco,; California, USA.; Binding of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 to both CD4 and one of several chemokine receptors (coreceptors) permits entry of virus into target cells. Infection of tissues may establish latent viral reservoirs as well as cause direct pathologic effects that manifest as clinic
CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function.: J Virol. 1999 Mar;73(3):2450-9. Unique Identifier : AIDSLINE MED/99139030; Mariani R; Wong S; Mulder LC; Wilkinson DA; Reinhart AL; LaRosa G; Nibbs R; O'Brien TR; Michael NL; Connor RI; Macdonald M; Busch M; Koup RA; Landau NR; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change
A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.: J Virol. 1999 Mar;73(3):2469-80. Unique Identifier : AIDSLINE MED/99139032; Salzwedel K; West JT; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; Mutations were introduced into the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane envelope glycoprotein, gp41, within a region immediately adjacent to the membrane-spanning domain. This region, which is predicted to form an alpha-helix, contains highly conserved hydrophobic residues and is
Productive infection of human peripheral blood mononuclear cells by feline immunodeficiency virus: implications for vector development.: J Virol. 1999 Mar;73(3):2491-8. Unique Identifier : AIDSLINE MED/99139034; Johnston J; Power C; Department of Clinical Neurosciences and Department of; Microbiology and Infectious Diseases, University of Calgary,; Calgary, Alberta, Canada T2N 4N1.; Feline immunodeficiency virus (FIV) is a lentivirus causing immune suppression and neurological disease in cats. Like primate lentiviruses, FIV utilizes the chemokine receptor CXCR4 for infection. In addition, FIV gene expression has been demonstrated in immortalized human cell lines. To investigate the extent and mec
Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.: J Virol. 1999 Mar;73(3):2499-508. Unique Identifier : AIDSLINE MED/99139035; Ulich C; Dunne A; Parry E; Hooker CW; Gaynor RB; Harrich D; Division of Hematology and Oncology, Departments of Internal; Medicine and Microbiology, University of Texas Southwestern; Medical Center, Dallas, Texas 75235-8594, USA.; Tat expression is required for efficient human immunodeficiency virus type 1 (HIV-1) reverse transcription. In the present study, we generated a series of 293 cell lines that contained a provirus with a tat gene deletion (Deltatat). Cell lines that contained Deltatat and stably transfected vectors containing either wi
[Effective splenectomy in a patient with HIV-associated thrombocytopenia]: Rinsho Ketsueki. 1998 Nov;39(11):1137-9. Unique Identifier : AIDSLINE MED/99083660; Kato Y; Nakamura K; Haraguchi K; Ajima A; Fujita H; Tomiyama J; Kudo H; Onozawa Y; Ohnishi K; Umekita N; Department of Internal Medicine, Tokyo Metropolitan Bokuto; General Hospital.; A 31-year-old man presented with a 3-month history of petechial hemorrhages. Physical examination revealed no splenomegaly. The patient s platelet count was 1.0 x 10(9)/l and bone marrow aspiration showed an elevated number of megakaryocytes. A diagnosis of HIV-associated thrombocytopenia was made on the basis of HIV
[Laboratory diagnosis of viral infections. 9. Viral infections related to blood transfusion and organ transplantation]: Rinsho Byori. 1998 Nov;Suppl 108:111-5. Unique Identifier : AIDSLINE MED/99119807; Miyamoto A; Tsutsumi Y; Sato H; Maeda Y
[Chemotherapy and vaccines used for the management of viral infections]: Rinsho Byori. 1998 Nov;Suppl 108:36-41. Unique Identifier : AIDSLINE MED/99119798; Yamane S
[Laboratory diagnosis of viral infections. 7. Opportunistic infection by herpesviruses (human cytomegalovirus, Epstein-Barr virus, and human herpesvirus 8)]: Rinsho Byori. 1998 Nov;Suppl 108:98-104. Unique Identifier : AIDSLINE MED/99119805; Okuno T
Gray-white, spherical deposition on retinal vessel associated with acute retinal necrosis and diabetic retinopathy in HTLV-I carriers.: Jpn J Ophthalmol. 1998 Nov-Dec;42(6):490-4. Unique Identifier : AIDSLINE MED/99101832; Nakao K; Ohba N; Uemura A; Okubo A; Sameshima M; Hayami K; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.; Tiny, gray-white, spherical deposits were found on the retinal vessels and vitreoretinal interface of the fovea in a 55-year-old woman with acute retinal necrosis due to varicella-zoster virus, and in a 47-year-old man with preproliferative diabetic retinopathy. Both patients developed massive vitreous opacities due t
Multi-clonal expansion of unique human T-lymphotropic virus type-I-infected T cells with high growth potential in response to interleukin-2 in prodromal phase of adult T cell leukemia.: Leukemia. 1999 Feb;13(2):215-21. Unique Identifier : AIDSLINE MED/99148762; Hata T; Fujimoto T; Tsushima H; Murata K; Tsukasaki K; Atogami S; Sohda H; Honda S; Mine M; Yamada Y; Ikeda S; Kamihira S; Tomonaga M; Department of Hematology, Atomic Bomb Disease Institute, Nagasaki; University School of Medicine, Japan.; We established a simple IL-2-dependent colony-forming assay for T cells infected with human T-lymphotropic virus type-I (HTLV-I). IL-2-dependent cell lines were subsequently established by expanding individual colonies in liquid cultures. Lymphocyte-rich fractions were prepared from 31 HTLV-I carriers, 12 patients wit
In vitro infection of CD4+ T lymphocytes with HTLV-I generates immortalized cell lines coexpressing lymphoid and myeloid cell markers.: Leukemia. 1999 Feb;13(2):222-9. Unique Identifier : AIDSLINE MED/99148763; Tricarico M; Macchi B; D'Atri S; Morrone S; Bonmassar E; Fuggetta MP; Graziani G; Institute of Experimental Medicine, National Research Council,; Area di Ricerca di Tor Vergata, Rome, Italy.; The human T cell leukemia/lymphoma virus (HTLV-I) is the etiologic agent of adult T cell leukemia (ATL). CD4+ lymphocytes are the preferential targets of infection, even though other cell types can be infected in vitro by the virus. Although ATL cells show CD3 and CD4 surface markers, some ATL-derived cell lines were
Development of an Epstein-Barr virus type 2 (EBV-2)-associated hepatic B cell non-Hodgkin's lymphoma in an HIV-1-infected patient following a change in the EBV dominant type.: Leukemia. 1999 Feb;13(2):298-301. Unique Identifier : AIDSLINE MED/99148773; Buisson M; Morand P; Peoc'h M; Bouchard O; Bourgeat MJ; Seigneurin JM; Laboratoire de Virologie Medicale Moleculaire, RHAP-CNRS,; Faculte de Medecine, Grenoble, France.; From the longitudinal study of a cohort of HIV-positive patients, we report the case of a patient who initially harbored the Epstein-Barr virus (EBV) type 1 and subsequently developed an EBV-2-associated non-Hodgkin s B lymphoma a few years after an EBV-2 reactivation, or an exogenous reactivation, in the blood. At th
[Pneumocystis carinii is still a dangerous opportunist. The infection is continuously a threat to immunocompromised patients]: Lakartidningen. 1999 Jan 27;96(4):328-31. Unique Identifier : AIDSLINE MED/99148960; Olsson M; Elvin K; Linder E; Lofdahl S; Wahlgren M; Parasitologiska enheten, Smittskyddsinstitutet, Stockholm.; Despite recent decrease in the incidence of Pneumocystis carinii pneumonia (PCP) among patients infected with HIV (human immunodeficiency virus), PCP remains a threat to other categories of immunocompromised patients. The article provides an outline of recent, mainly molecular genetic, findings in P. carinii research,
India has the largest number of people infected with HIV [news]: Lancet. 1999 Jan 2;353(9146):48. Unique Identifier : AIDSLINE MED/99146568; Kumar S
US drug project abandons needle exchange [news]: Lancet. 1999 Jan 2;353(9146):49. Unique Identifier : AIDSLINE MED/99146569; Morris K
HIV-1 replication in patients with undetectable plasma virus receiving HAART. Highly active antiretroviral therapy [letter]: Lancet. 1999 Jan 9;353(9147):119-20. Unique Identifier : AIDSLINE MED/99146508; Natarajan V; Bosche M; Metcalf JA; Ward DJ; Lane HC; Kovacs JA
Further clues emerge for strategies to attack HIV [news]: Lancet. 1999 Jan 9;353(9147):125. Unique Identifier : AIDSLINE MED/99146514; McCarthy M
No clinical trials sanctioned for South Africa's controversial HIV drug [news]: Lancet. 1999 Jan 9;353(9147):125. Unique Identifier : AIDSLINE MED/99146515; Baleta A
Widespread horror over killing of AIDS activist in South Africa [news]: Lancet. 1999 Jan 9;353(9147):130. Unique Identifier : AIDSLINE MED/99146518; Baleta A
Access to treatment for HIV in developing countries [letter]: Lancet. 1999 Jan 9;353(9147):153. Unique Identifier : AIDSLINE MED/99146535; Kroes AC; Leendertse D; Spaan WJ
Rapid serodiagnosis of Mycobacterium avium-intracellulare complex infection by ELISA with cord factor (trehalose 6, 6'-dimycolate), and serotyping using the glycopeptidolipid antigen.: Microbiol Immunol. 1998;42(10):689-96. Unique Identifier : AIDSLINE MED/99074175; Enomoto K; Oka S; Fujiwara N; Okamoto T; Okuda Y; Maekura R; Kuroki T; Yano I; Department of Bacteriology, Osaka City University Medical School,; Osaka, Japan.; Mycobacterium avium-intracellulare complex (MAC) is one of the most important opportunistic pathogens, particularly in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine whether an enzyme-linked immunosorbent assay (ELISA) using trehalose 6,6 -dimycolate (TDM) as an antigen
Genomic analysis of the viral population in genital secretions early after infection of simian immunodeficiency viruses in macaque monkeys.: Microbiol Immunol. 1998;42(10):715-22. Unique Identifier : AIDSLINE MED/99074178; Enose Y; Ibuki K; Shimada T; Ui M; Hayami M; Institute for Virus Research, Kyoto University, Kyoto, Japan.; To clarify the change in the viral population during passage from the vaginal cavity to blood circulation and vice versa, we examined the viral clones detected in cells in vaginal washes (VWCs) early after inoculation and after systemic infection with polyclonal SIV. In two intravaginally inoculated monkeys, the viral
The inter-relation of maternal immune competence, HIV-1 viral load, and nutritional status in preventing vertical transmission: an alternative to chemoprophylaxis?: Med Hypotheses. 1998 Nov;51(5):389-97. Unique Identifier : AIDSLINE MED/99063213; Moran PJ; Welles SL; Williams MA; Department of Epidemiology, University of Washington, School of; Public Health and Community Medicine, Seattle 98195, USA.; As the human immunodeficiency virus (HIV) global pandemic moves towards the end of its second decade, women of reproductive age throughout the world have been shown to be increasingly at risk for acquiring HIV-1 infection. Recently, the focus for preventive measures has expanded to include preventing the perinatal tra
Itraconazole and HIV protease inhibitors: an important interaction [letter]: Med J Aust. 1999 Jan 4;170(1):46-7. Unique Identifier : AIDSLINE MED/99150739; MacKenzie-Wood AR; Whitfeld MJ; Ray JE
[A functional model of the central epitope of the V3 loop of HIV-1 gp120 when complexed with antibodies]: Mol Biol (Mosk). 1998 Nov-Dec;32(6):1062-74. Unique Identifier : AIDSLINE MED/99128748; Shchelkanov MIu; Iaroslavtseva NG; Emel'ianov AV; Sakhuriia IB; Abelian AV; Verevochkin SV; Kozlov AP; Karamov EV
[Tandem bifunctional derivatives of short oligonucleotides--inhibitors of replication of the human immunodeficiency virus in cell culture]: Mol Biol (Mosk). 1998 Nov-Dec;32(6):1085-90. Unique Identifier : AIDSLINE MED/99128749; Pliasunova OA; Mamaeva OA; Pyshnyi DV; Pyshnaia IA; Ivanova EM; Vorob'ev PE; Zarytova VF; Pokrovskii AG
[Some aspects of the pathogenesis of HIV infection]: Mol Biol (Mosk). 1998 Nov-Dec;32(6):933-9. Unique Identifier : AIDSLINE MED/99128728; Eremin VF; Votiakov VI; Titov LP
Dilated cardiomyopathy in HIV-infected patients [letter]: N Engl J Med. 1999 Mar 4;340(9):732; discussion 733-5. Unique Identifier : AIDSLINE MED/99150075; Chariot P; Perchet H; Monnet I
Dilated cardiomyopathy in HIV-infected patients [letter]: N Engl J Med. 1999 Mar 4;340(9):732-3; discussion 733-4. Unique Identifier : AIDSLINE MED/99150076; Malnick S; Goland S
Dilated cardiomyopathy in HIV-infected patients [letter]: N Engl J Med. 1999 Mar 4;340(9):733-4. Unique Identifier : AIDSLINE MED/99150077; Flotats A; Domingo P; Carrio I
[Accidental exposure to blood and the risk of transmission of virus infections for various occupational groups in Amsterdam, 1986-1996]: Ned Tijdschr Geneeskd. 1998 Oct 17;142(42):2312-4. Unique Identifier : AIDSLINE MED/99082047; Berger CM; Leentvaar-Kuijpers A; Van Doornum GJ; Coutinho RA; GG&GD, divisie Volksgezondheid en Milieu, Nieuwe Achtergracht,; Amsterdam.; Since 1986 the number of parenteral exposures to potentially infectious blood reported to the Amsterdam Public Health Service increases every year. The number of needlestick accidents increased significantly from 64 in 1986 to 166 in 1996 whereas the number of other exposures decreased from 59 to 44 in these years. Th
Chemokines, renal disease, and HIV infection.: Nephron. 1999 Jan;81(1):5-16. Unique Identifier : AIDSLINE MED/99102657; Wenzel UO; Stahl RA; Department of Medicine, Division of Nephrology, University of; Hamburg, Germany.wenzel@uke.uni-hamburg.de; Renal disease is characterized by the influx of leukocytes into the injured tissue. Before leukocytes can exert their effects on renal damage or repair, they have to reach the site of injury. To recruit specific populations of leukocytes during inflammation is the role of a family of cytokines called chemokines. The c
HTLV-II risk factors in Native Americans in Florida.: Neuroepidemiology. 1999;18(1):37-47. Unique Identifier : AIDSLINE MED/99051393; Lowis GW; Sheremata WA; Wickman PR; Dube S; Dube K; Poiesz BJ; Department of Epidemiology and Public Health, School of Medicine,; University of Miami, Fla. 33136, USA.; Earlier virologic studies established that human T-cell lymphotropic virus type II (HTLV-II) is the predominant retrovirus type found among Seminole Indians in southern Florida. We studied 46 members of the Seminole tribe living on 3 reservations to determine the risk factors for HTLV-II and to investigate disease ass
Neuronal death induced by SIN-1 in the presence of superoxide dismutase: protection by cyclic GMP.: Neuropharmacology. 1998 Aug;37(8):1071-9. Unique Identifier : AIDSLINE MED/99049382; Moro MA; Fernandez-Tome P; Leza JC; Lorenzo P; Lizasoain I; Departamento de Farmacologia, Facultad de Medicina, Universidad; Complutense de Madrid, Spain. nlfucm@eucmax.sim.ucm.es; The nitrovasodilator 3-morpholinosydnonimine (SIN-1) slowly decomposes to release both nitric oxide (NO) and superoxide (O2-) and thereby produces peroxynitrite (ONOO-), a powerful oxidant which has been proposed to mediate the toxic actions caused by NO. Indeed, ONOO has been shown to cause neuronal death and it has
Evaluation of nursing practice: process and critique.: Nurs Sci Q. 1998 Summer;11(2):64-8. Unique Identifier : AIDSLINE MED/99155485; Braunstein MS; Madonna University, Livonia, MI, USA.; This article describes the difficulties in conducting clinical trials to evaluate nursing practice models. Suggestions are offered for strengthening the process. A clinical trial of a nursing practice model based on a synthesis of Aristotelian theory with Rogers science is described. The rationale for decisions regar
Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation.: Oncogene. 1999 Feb 11;18(6):1341-9. Unique Identifier : AIDSLINE MED/99145414; Harhaj EW; Good L; Xiao G; Sun SC; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033, USA.; Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell malignancy. A key step in HTLV-I-induced leukemigenesis is induction of abnormal T-cell growth and survival. Unlike antigen-stimulated T cells, which cease proliferation after a finite number of
Mefloquine-induced grand mal seizure in tubercular meningitis.: Panminerva Med. 1998 Dec;40(4):345-6. Unique Identifier : AIDSLINE MED/99139238; Bregani ER; Tien TV; Figini G; Division of Emergency Medicine, Ospedale Maggiore IRCCS, Milan,; Italy.; Mefloquine represents a promising antimalarial drug against Plasmodium falciparum. It has been related to an increase in seizure frequency in epileptic patients and should not be administered to patients with a history of convulsions, epilepsy in first degree relatives, or serious psychiatric disorders. We report a ca
[What motivates people to get tested for HIV antibodies?]: Pol Arch Med Wewn. 1998 May;99(5):403-6. Unique Identifier : AIDSLINE MED/99033678; Wiercinska-Drapalo A; Rogowska-Szadkowska D; Prokopowicz D; Klinika Obserwacyjno-Zakazna Akademii Medycznej w Bialymstoku.; The aim of the study was to evaluate reasons for anti-HIV testing among persons admitted to Outpatient Counseling Unit. Serum examination for antibodies against HIV were performed in 389 persons during 8 years of the Unit activity. The most frequently it was analysed in intravenous drug users. However there are still
Model for using hip-hop music for small group HIV/AIDS prevention counseling with African American adolescents and young adults.: Patient Educ Couns. 1998 Oct;35(2):127-37. Unique Identifier : AIDSLINE MED/99150617; Stephens T; Braithwaite RL; Taylor SE; Department of Behavioral Sciences and Health Education, Rollins; School of Public Health, Emory University, Atlanta, GA 30322,; USA. tstephe@sph.emory.edu; Currently little attention has been directed, with the exception of peer education efforts, to constructively develop new and innovative ways to promote HIV/AIDS primary prevention among African American (AA) adolescents and young adults. With this in mind, the aim of this conceptual effort is to present a HIV/AIDS pr
Mucocutaneous manifestations in children with HIV infection and AIDS.: Pediatr Dermatol. 1998 Nov-Dec;15(6):429-34. Unique Identifier : AIDSLINE MED/99091191; El Hachem M; Bernardi S; Pianosi G; Krzysztofiak A; Livadiotti S; Gattinara GC; Department of Dermatology, Bambino Gesu Children's Hospital and; Health Research Institute-Rome, Italy.; Mucocutaneous diseases are more frequent in HIV/AIDS-infected children than in the normal population. We analyze mucocutaneous disorders with atypical presentations in a large population of HIV-infected children, with or without full-blown AIDS, compared to a population of HIV seroreverted children. The majority of th
Stepwise transformation of a cholera toxin and a p24 (HIV-1) epitope into D-peptide analogs.: Protein Eng. 1998 Oct;11(10):941-8. Unique Identifier : AIDSLINE MED/99077031; Kramer A; Stigler R