Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity.

Farmaco. 1998 Jul 30;53(7):455-61. Unique Identifier : AIDSLINE MED/99053177
Sanna P; Carta A; Loriga M; Zanetti S; Sechi L; Istituto di Chimica Farmaceutica e Tossicologica, Sassari, Italy.

Abstract: A series of variously substituted quinoxalin-3-ones bearing an ethoxycarbonyl or carboxy group in the C-2 position has been prepared and their structures proved by 1H NMR spectroscopy. The obtained compounds were investigated in vitro for antimicrobial and anticancer activities. Preliminary results showed a moderate activity against a few strains of bacteria but no significant anticancer and anti-HIV activity.

Keywords: JOURNAL ARTICLE Anti-Infective Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antineoplastic Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Comparative Study Human Microbial Sensitivity Tests Quinoxalines/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Structure-Activity Relationship Tumor Cells, Cultured/DRUG EFFECTS
990330
A9931126

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