Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives.

Farmaco. 1998 Jul 30;53(7):462-7. Unique Identifier : AIDSLINE MED/99053178
Dogan HN; Rollas S; Erdeniz H; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Marmara; University, Istanbul, Turkey.

Abstract: In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, 1H NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity.
Keywords: JOURNAL ARTICLE Anti-Infective Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antifungal Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Comparative Study HIV/DRUG EFFECTS Microbial Sensitivity Tests Molecular Structure Neoplasms/DRUG THERAPY Semicarbazides/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Structure-Activity Relationship Support, Non-U.S. Gov'tKWDjournalarticleanti-infectiveagents/chemistry/KWDchemicalsynthesis/pharmacologyantifungalagents/chemistry/KWDchemicalsynthesis/pharmacologycomparativestudyhiv/drugeffectsmicrobialsensitivitytestsmolecularstructureneoplasms/drugtherapysemicarbazides/chemistry/KWDchemicalsynthesis/pharmacologystructure-activityrelationshipsupport,non-uKWDsKWDgov't
990330
A9931125

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .