Patterns of cytokine expression in AIDS-related non-Hodgkin's lymphoma.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Patterns of cytokine expression in AIDS-related non-Hodgkin's lymphoma.

Br J Haematol. 1998 Oct;103(1):143-9. Unique Identifier : AIDSLINE MED/99006787
Pastore C; Gaidano G; Ghia P; Fassone L; Cilia AM; Gloghini A; Capello D; Buonaiuto D; Gonella S; Roncella S; Carbone A; Saglio G; Dipartimento di Scienze Cliniche e Biologiche, Ospedale San; Luigi, Universita di Torino, Orbassano-Torino, Italy.

Abstract: The pathogenesis of AIDS-related non-Hodgkin's lymphomas (AIDS-NHL) involves accumulation of genetic lesions, stimulation and selection by antigen, as well as infection by viruses. Deregulation of cytokine loops has also been proposed to contribute to AIDS-NHL development, although data are available only for a limited number of cytokines. In this study we have utilized a panel of AIDS-NHL cell lines to investigate in detail the pattern of tumour expression and production of a wide spectrum of cytokines. The cytokines investigated included interleukin (IL)-1alpha, IL-1beta, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, TNF alpha, TNF beta, IFN gamma, TGF beta2, G-CSF, GM-CSF and SCF. The AIDS-NHL cell lines utilized were representative of both AIDS-related Burkitt lymphoma (AIDS-BL) and AIDS-related body cavity-based lymphoma (AIDS-BCBL). Overall, AIDS-NHL were found to produce IL-6, IL-10 and TNF beta, although with different patterns depending upon the biological features of the tumour. Production of high levels of IL10 preferentially associated with Epstein-Barr virus (EBV) positive AIDS-BL and AIDS-BCBL, although lower levels of the cytokine were also detectable among EBV-negative AIDS-BL. Production of IL-6 was restricted to EBV-positive AIDS-BL and AIDS-BCBL, whereas it was absent among EBV-negative AIDS-BL. Production of TNF beta clustered with AIDS-BL, whereas this was absent among AIDS-BCBL. These results define that the pattern of cytokine expression of AIDS-NHL depends upon the biological features of the tumour and may have implications for the pathogenesis of these disorders.

Keywords: JOURNAL ARTICLE Cytokines/*METABOLISM Herpesvirus, Kaposi Sarcoma-Associated/ISOLATION & PURIF Human Interleukins/METABOLISM Lymphoma, AIDS-Related/*METABOLISM/VIROLOGY Reverse Transcriptase Polymerase Chain Reaction/METHODS RNA/ANALYSIS Support, Non-U.S. Gov't Tumor Cells, Cultured Tumor Necrosis Factor/METABOLISM
990330
A9931120

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